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Victor Rodwell

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TOP 3
Calvin N Steussy; Aaron D Robison; Alison M Tetrick; Jeffrey T Knight; Victor W Rodwell; Cynthia V Stauffacher; Autumn Sutherlin
A structural limitation on enzyme activity: the case of HMG-CoA synthase.
Calvin N Steussy; Anthony A Vartia; John W Burgner; Autumn Sutherlin; Victor W Rodwell; Cynthia V Stauffacher
X-ray crystal structures of HMG-CoA synthase from Enterococcus faecalis and a complex with its second substrate/inhibitor acetoacetyl-CoA.
Stephanie S Doun; John W Burgner; Scott D Briggs; Victor W Rodwell
Enterococcus faecalis phosphomevalonate kinase.

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All Publications

2006: Calvin N Steussy; Aaron D Robison; Alison M Tetrick; Jeffrey T Knight; Victor W Rodwell; Cynthia V Stauffacher; Autumn Sutherlin
A structural limitation on enzyme activity: the case of HMG-CoA synthase.
Biochemistry 2006;45(48):14407-14.
2005: Calvin N Steussy; Anthony A Vartia; John W Burgner; Autumn Sutherlin; Victor W Rodwell; Cynthia V Stauffacher
X-ray crystal structures of HMG-CoA synthase from Enterococcus faecalis and a complex with its second substrate/inhibitor acetoacetyl-CoA.
Biochemistry 2005;44(43):14256-67.
2005: Stephanie S Doun; John W Burgner; Scott D Briggs; Victor W Rodwell
Enterococcus faecalis phosphomevalonate kinase.
Protein science : a publication of the Protein Society 2005;14(5):1134-9.
2004: Autumn Sutherlin; Victor W Rodwell
Multienzyme mevalonate pathway bioreactor.
Biotechnology and bioengineering 2004;87(4):546-51.
2004: Matija Hedl; Victor W Rodwell
Inhibition of the class II HMG-CoA reductase of Pseudomonas mevalonii.
Protein science : a publication of the Protein Society 2004;13(6):1693-7.
2004: Matija Hedl; Lydia Tabernero; Cynthia V Stauffacher; Victor W Rodwell
Class II 3-hydroxy-3-methylglutaryl coenzyme A reductases.
Journal of bacteriology 2004;186(7):1927-32.
2004: Matija Hedl; Victor W Rodwell
Enterococcus faecalis mevalonate kinase.
Protein science : a publication of the Protein Society 2004;13(3):687-93.
2004: Jon A Friesen; Victor W Rodwell
The 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductases.
Genome biology 2004;5(11):248.
2003: Lydia Tabernero; Victor W Rodwell; Cynthia V Stauffacher
Crystal structure of a statin bound to a class II hydroxymethylglutaryl-CoA reductase.
The Journal of biological chemistry 2003;278(22):19933-8.
2002: Autumn Sutherlin; Matija Hedl; Barbara Sanchez-Neri; John W Burgner; Cynthia V Stauffacher; Victor W Rodwell
Enterococcus faecalis 3-hydroxy-3-methylglutaryl coenzyme A synthase, an enzyme of isopentenyl diphosphate biosynthesis.
Journal of bacteriology 2002;184(15):4065-70.
2002: Matija Hedl; Autumn Sutherlin; E Imogen Wilding; Marie Mazzulla; Damien McDevitt; Pamela Lane; John W Burgner; Kevin R Lehnbeuter; Cynthia V Stauffacher; Michael N Gwynn; Victor W Rodwell
Enterococcus faecalis acetoacetyl-coenzyme A thiolase/3-hydroxy-3-methylglutaryl-coenzyme A reductase, a dual-function protein of isopentenyl diphosphate biosynthesis.
Journal of bacteriology 2002;184(8):2116-22.
2000: E Imogen Wilding; D Y Kim; AP Bryant; Michael N Gwynn; R Dwayne Lunsford; Damien McDevitt; J E Myers; Martin Rosenberg; Daniel Sylvester; Cynthia V Stauffacher; Victor W Rodwell
Essentiality, expression, and characterization of the class II 3-hydroxy-3-methylglutaryl coenzyme A reductase of Staphylococcus aureus.
Journal of bacteriology 2000;182(18):5147-52.
2000: DY Kim; Cynthia V Stauffacher; Victor W Rodwell
Dual coenzyme specificity of Archaeoglobus fulgidus HMG-CoA reductase.
Protein science : a publication of the Protein Society 2000;9(6):1226-34.
2000: D Y Kim; Cynthia V Stauffacher; Victor W Rodwell
Engineering of Sulfolobus solfataricus HMG-CoA reductase to a form whose activity is regulated by phosphorylation and dephosphorylation.
Biochemistry 2000;39(9):2269-75.
2000: Victor W Rodwell; M J Beach; Kenneth M Bischoff; Daniel Bochar; B G Darnay; Jon A Friesen; J F Gill; Matija Hedl; T Jordan-Starck; Peter J Kennelly; DY Kim; Y Wang
3-Hydroxy-3-methylglutaryl-CoA reductase.
Methods in enzymology 2000;324():259-80.
1999: DY Kim; Daniel Bochar; Cynthia V Stauffacher; Victor W Rodwell
Expression and characterization of the HMG-CoA reductase of the thermophilic archaeon Sulfolobus solfataricus.
Protein expression and purification 1999;17(3):435-42.
1999: Daniel Bochar; Cynthia V Stauffacher; Victor W Rodwell
Investigation of the conserved lysines of Syrian hamster 3-hydroxy-3-methylglutaryl coenzyme A reductase.
Biochemistry 1999;38(48):15848-52.
1999: Daniel Bochar; Lydia Tabernero; Cynthia V Stauffacher; Victor W Rodwell
Aminoethylcysteine can replace the function of the essential active site lysine of Pseudomonas mevalonii 3-hydroxy-3-methylglutaryl coenzyme A reductase.
Biochemistry 1999;38(28):8879-83.
1999: Lydia Tabernero; Daniel Bochar; Victor W Rodwell; Cynthia V Stauffacher
Substrate-induced closure of the flap domain in the ternary complex structures provides insights into the mechanism of catalysis by 3-hydroxy-3-methylglutaryl-CoA reductase.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(13):7167-71.
1999: Daniel Bochar; Cynthia V Stauffacher; Victor W Rodwell
Sequence comparisons reveal two classes of 3-hydroxy-3-methylglutaryl coenzyme A reductase.
Molecular genetics and metabolism 1999;66(2):122-7.
1998: R S Rosenthal; Victor W Rodwell
Purification and characterization of the heteromeric transcriptional activator MvaT of the Pseudomonas mevalonii mvaAB operon.
Protein science : a publication of the Protein Society 1998;7(1):178-84.
1997: K S Rogers; Victor W Rodwell; P Geiger
Active form of Pseudomonas mevalonii 3-hydroxy-3-methylglutaryl coenzyme A reductase.
Biochemical and molecular medicine 1997;61(1):114-20.
1997: Daniel Bochar; J R Brown; W F Doolittle; H P Klenk; W Lam; M E Schenk; Cynthia V Stauffacher; Victor W Rodwell
3-hydroxy-3-methylglutaryl coenzyme A reductase of Sulfolobus solfataricus: DNA sequence, phylogeny, expression in Escherichia coli of the hmgA gene, and purification and kinetic characterization of the gene product.
Journal of bacteriology 1997;179(11):3632-8.
1997: Jon A Friesen; Victor W Rodwell
Protein engineering of the HMG-CoA reductase of Pseudomonas mevalonii. Construction of mutant enzymes whose activity is regulated by phosphorylation and dephosphorylation.
Biochemistry 1997;36(8):2173-7.
1997: Jon A Friesen; Victor W Rodwell
Identification of elements critical for phosphorylation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by adenosine monophosphate-activated protein kinase: protein engineering of the naturally nonphosphorylatable 3-hydroxy-3-methylglutaryl coenzyme A reductase from Pseudomonas mevalonii.
Biochemistry 1997;36(5):1157-62.
1997: Kenneth M Bischoff; Victor W Rodwell
3-Hydroxy-3-methylglutaryl-coenzyme A reductase of Haloferax volcanii: role of histidine 398 and attenuation of activity by introduction of negative charge at position 404.
Protein science : a publication of the Protein Society 1997;6(1):156-61.
1996: Jon A Friesen; C M Lawrence; Cynthia V Stauffacher; Victor W Rodwell
Structural determinants of nucleotide coenzyme specificity in the distinctive dinucleotide binding fold of HMG-CoA reductase from Pseudomonas mevalonii.
Biochemistry 1996;35(37):11945-50.
1996: K M Bischoff; Victor W Rodwell
3-Hydroxy-3-methylglutaryl-coenzyme A reductase from Haloferax volcanii: purification, characterization, and expression in Escherichia coli.
Journal of bacteriology 1996;178(1):19-23.
1995: C M Lawrence; Victor W Rodwell; Cynthia V Stauffacher
Crystal structure of Pseudomonas mevalonii HMG-CoA reductase at 3.0 angstrom resolution.
Science (New York, N.Y.) 1995;268(5218):1758-62.
1995: C M Lawrence; Young-In Chi; Victor W Rodwell; Cynthia V Stauffacher
Crystallization of HMG-CoA reductase from Pseudomonas mevalonii.
Acta crystallographica. Section D, Biological crystallography 1995;51(Pt 3):386-9.
1994: R V Omkumar; Victor W Rodwell
Phosphorylation of Ser871 impairs the function of His865 of Syrian hamster 3-hydroxy-3-methylglutaryl-CoA reductase.
The Journal of biological chemistry 1994;269(24):16862-6.
1994: K Frimpong; Victor W Rodwell
Catalysis by Syrian hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Proposed roles of histidine 865, glutamate 558, and aspartate 766.
The Journal of biological chemistry 1994;269(15):11478-83.
1994: R V Omkumar; B G Darnay; Victor W Rodwell
Modulation of Syrian hamster 3-hydroxy-3-methylglutaryl-CoA reductase activity by phosphorylation. Role of serine 871.
The Journal of biological chemistry 1994;269(9):6810-4.
1994: K Frimpong; Victor W Rodwell
The active site of hamster 3-hydroxy-3-methylglutaryl-CoA reductase resides at the subunit interface and incorporates catalytically essential acidic residues from separate polypeptides.
The Journal of biological chemistry 1994;269(2):1217-21.
1993: K Frimpong; B G Darnay; Victor W Rodwell
Syrian hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase expressed in Escherichia coli: production of homogeneous protein.
Protein expression and purification 1993;4(4):337-44.
1993: B G Darnay; Victor W Rodwell
His865 is the catalytically important histidyl residue of Syrian hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
The Journal of biological chemistry 1993;268(12):8429-35.
1992: K M Bischoff; Victor W Rodwell
Biosynthesis and characterization of (S)-and (R)-3-hydroxy-3-methylglutaryl coenzyme A.
Biochemical medicine and metabolic biology 1992;48(2):149-58.
1992: B G Darnay; Y Wang; Victor W Rodwell
Identification of the catalytically important histidine of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
The Journal of biological chemistry 1992;267(21):15064-70.
1991: Y L Wang; Victor W Rodwell
The cis-acting regulatory element of the mvaAB operon of Pseudomonas mevalonii.
Journal of bacteriology 1991;173(12):3803-6.
1990: Y Wang; B G Darnay; Victor W Rodwell
Identification of the principal catalytically important acidic residue of 3-hydroxy-3-methylglutaryl coenzyme A reductase.
The Journal of biological chemistry 1990;265(35):21634-41.
1989: D H Anderson; Victor W Rodwell
Nucleotide sequence and expression in Escherichia coli of the 3-hydroxy-3-methylglutaryl coenzyme A lyase gene of Pseudomonas mevalonii.
Journal of bacteriology 1989;171(12):6468-72.
1989: T C Jordan-Starck; Victor W Rodwell
Role of cysteine residues in Pseudomonas mevalonii 3-hydroxy-3-methylglutaryl-CoA reductase. Site-directed mutagenesis and characterization of the mutant enzymes.
The Journal of biological chemistry 1989;264(30):17919-23.
1989: T C Jordan-Starck; Victor W Rodwell
Pseudomonas mevalonii 3-hydroxy-3-methylglutaryl-CoA reductase. Characterization and chemical modification.
The Journal of biological chemistry 1989;264(30):17913-8.
1989: Y L Wang; M J Beach; Victor W Rodwell
(S)-3-hydroxy-3-methylglutaryl coenzyme A reductase, a product of the mva operon of Pseudomonas mevalonii, is regulated at the transcriptional level.
Journal of bacteriology 1989;171(10):5567-71.
1989: D S Scher; Victor W Rodwell
3-Hydroxy-3-methylglutaryl coenzyme A lyase from Pseudomonas mevalonii.
Biochimica et biophysica acta 1989;1003(3):321-6.
1989: M J Beach; Victor W Rodwell
Cloning, sequencing, and overexpression of mvaA, which encodes Pseudomonas mevalonii 3-hydroxy-3-methylglutaryl coenzyme A reductase.
Journal of bacteriology 1989;171(6):2994-3001.
1985: J F Gill; M J Beach; Victor W Rodwell
Mevalonate utilization in Pseudomonas sp. M. Purification and characterization of an inducible 3-hydroxy-3-methylglutaryl coenzyme A reductase.
The Journal of biological chemistry 1985;260(16):9393-8.
1984: J F Gill; M J Beach; Victor W Rodwell
Transport of mevalonate by Pseudomonas sp. strain M.
Journal of bacteriology 1984;160(1):294-8.