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Gabriele Bierbaum

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M Josten; Markus Kostrzewa; Marion Reif; Terry Roemer; Holger Rohde; Hans-Georg Sahl; Katrin Sparbier; Christiane Szekat; Nahed Al-Sabti; Gabriele Bierbaum
Analysis of the Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrum of Staphylococcus aureus Identifies Mutations That Allow Differentiation of the Main Clonal Lineages.
Andrea Jansen; Jean C Lee; Wiebke Schröder; Christiane Szekat; Michael Türck; Christiane Wolz; Christiane Goerke; Gabriele Bierbaum
Production of capsular polysaccharide does not influence Staphylococcus aureus vancomycin susceptibility.
Peter Sass; Axel Strittmatter; Christiane Szekat; Anne Berscheid; Gerhard Gottschalk; Andrea Jansen; Marion Oedenkoven; Gabriele Bierbaum
Genome sequence of Staphylococcus aureus VC40, a vancomycin- and daptomycin-resistant strain, to study the genetics of development of resistance to currently applied last-resort antibiotics.

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2013: M Josten; Markus Kostrzewa; Marion Reif; Terry Roemer; Holger Rohde; Hans-Georg Sahl; Katrin Sparbier; Christiane Szekat; Nahed Al-Sabti; Gabriele Bierbaum
Analysis of the Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrum of Staphylococcus aureus Identifies Mutations That Allow Differentiation of the Main Clonal Lineages.
Journal of clinical microbiology 2013;51(6):1809-17.
2013: Andrea Jansen; Jean C Lee; Wiebke Schröder; Christiane Szekat; Michael Türck; Christiane Wolz; Christiane Goerke; Gabriele Bierbaum
Production of capsular polysaccharide does not influence Staphylococcus aureus vancomycin susceptibility.
BMC microbiology 2013;13():65.
2012: Peter Sass; Axel Strittmatter; Christiane Szekat; Anne Berscheid; Gerhard Gottschalk; Andrea Jansen; Marion Oedenkoven; Gabriele Bierbaum
Genome sequence of Staphylococcus aureus VC40, a vancomycin- and daptomycin-resistant strain, to study the genetics of development of resistance to currently applied last-resort antibiotics.
Journal of bacteriology 2012;194(8):2107-8.
2012: Anne Berscheid; Ambrose L Cheung; Peter Sass; Konstantin Weber-Lassalle; Gabriele Bierbaum
Revisiting the genomes of the Staphylococcus aureus strains NCTC 8325 and RN4220.
International journal of medical microbiology : IJMM 2012;302(2):84-7.
2012: Michael Türck; Gabriele Bierbaum
Purification and activity testing of the full-length YycFGHI proteins of Staphylococcus aureus.
PloS one 2012;7(1):e30403.
2011: Michael Nagel; Tina Reuter; Andrea Jansen; Christiane Szekat; Gabriele Bierbaum
Influence of ciprofloxacin and vancomycin on mutation rate and transposition of IS256 in Staphylococcus aureus.
International journal of medical microbiology : IJMM 2011;301(3):229-36.
2011: Anna Maria Herzner; Andrea Jansen; M Josten; Jörn Piel; Ricarda Reinartz; Hans-Georg Sahl; Stephanie Schmitz; Christiane Szekat; Anja Yakéléba; Jasmin Dischinger; Gabriele Bierbaum
Expression of the lantibiotic mersacidin in Bacillus amyloliquefaciens FZB42.
PloS one 2011;6(7):e22389.
2010: Till F Schäberle; Emilie Goralski; Edith Neu; Ozlem Erol; Georg Hölzl; Peter Dörmann; Gabriele Bierbaum; Gabriele M König
Marine myxobacteria as a source of antibiotics--comparison of physiology, polyketide-type genes and antibiotic production of three new isolates of Enhygromyxa salina.
Marine drugs 2010;8(9):2466-79.
2009: Günter Marklein; M Josten; U Klanke; E Müller; Regine Horré; T Maier; T Wenzel; M Kostrzewa; Gabriele Bierbaum; A Hoerauf; Hans-Georg Sahl
Matrix-assisted laser desorption ionization-time of flight mass spectrometry for fast and reliable identification of clinical yeast isolates.
Journal of clinical microbiology 2009;47(9):2912-7.
2009: Peter Sass; Gabriele Bierbaum
Native graS mutation supports the susceptibility of Staphylococcus aureus strain SG511 to antimicrobial peptides.
International journal of medical microbiology : IJMM 2009;299(5):313-22.
2009: Jasmin Dischinger; M Josten; Christiane Szekat; Hans-Georg Sahl; Gabriele Bierbaum
Production of the novel two-peptide lantibiotic lichenicidin by Bacillus licheniformis DSM 13.
PloS one 2009;4(8):e6788.
2009: Gabriele Bierbaum; Hans-Georg Sahl
Lantibiotics: mode of action, biosynthesis and bioengineering.
Current pharmaceutical biotechnology 2009;10(1):2-18.
2008: Vera Sass; Ulrike Pag; Alessandro Tossi; Gabriele Bierbaum; Hans-Georg Sahl
Mode of action of human beta-defensin 3 against Staphylococcus aureus and transcriptional analysis of responses to defensin challenge.
International journal of medical microbiology : IJMM 2008;298(7-8):619-33.
2008: Soyhan Bagci; Anna Maria Eis-Hübinger; Axel R Franz; Gabriele Bierbaum; Axel Heep; Oliver Schildgen; Peter Bartmann; Bernd Kupfer; Andreas Mueller
Detection of astrovirus in premature infants with necrotizing enterocolitis.
The Pediatric infectious disease journal 2008;27(4):347-50.
2008: Sonja Bonness; Christiane Szekat; Natalija Novak; Gabriele Bierbaum
Pulsed-field gel electrophoresis of Staphylococcus aureus isolates from atopic patients revealing presence of similar strains in isolates from children and their parents.
Journal of clinical microbiology 2008;46(2):456-61.
2008: Peter Sass; Andrea Jansen; Christiane Szekat; Vera Sass; Hans-Georg Sahl; Gabriele Bierbaum
The lantibiotic mersacidin is a strong inducer of the cell wall stress response of Staphylococcus aureus.
BMC microbiology 2008;8():186.
2007: Gabriele Bierbaum; Andrea Jansen
Tying the knot: making of lasso peptides.
Chemistry & biology 2007;14(7):734-5.
2007: Andrea Jansen; Michael Türck; Christiane Szekat; Michael Nagel; Indra Clever; Gabriele Bierbaum
Role of insertion elements and yycFG in the development of decreased susceptibility to vancomycin in Staphylococcus aureus.
International journal of medical microbiology : IJMM 2007;297(4):205-15.
2007: Peter Sass; Gabriele Bierbaum
Lytic activity of recombinant bacteriophage phi11 and phi12 endolysins on whole cells and biofilms of Staphylococcus aureus.
Applied and environmental microbiology 2007;73(1):347-52.
2006: Stephanie Schmitz; Anja Hoffmann; Christiane Szekat; Brian Rudd; Gabriele Bierbaum
The lantibiotic mersacidin is an autoinducing peptide.
Applied and environmental microbiology 2006;72(11):7270-7.
2004: Danuta Kruszewska; Hans-Georg Sahl; Gabriele Bierbaum; Ulrike Pag; Sean O Hynes; Asa Ljungh
Mersacidin eradicates methicillin-resistant Staphylococcus aureus (MRSA) in a mouse rhinitis model.
The Journal of antimicrobial chemotherapy 2004;54(3):648-53.
2003: Franziska Schaaff; Gabriele Bierbaum; Nicole Baumert; Peter Bartmann; Hans-Georg Sahl
Mutations are involved in emergence of aminoglycoside-induced small colony variants of Staphylococcus aureus.
International journal of medical microbiology : IJMM 2003;293(6):427-35.
2003: Christiane Szekat; Ralph W Jack; Dirk Skutlarek; Harald Färber; Gabriele Bierbaum
Construction of an expression system for site-directed mutagenesis of the lantibiotic mersacidin.
Applied and environmental microbiology 2003;69(7):3777-83.
2003: Shang-Te Danny Hsu; Eefjan Breukink; Gabriele Bierbaum; Hans-Georg Sahl; Ben de Kruijff; Robert Kaptein; Nico A J van Nuland; Alexandre Bonvin
NMR study of mersacidin and lipid II interaction in dodecylphosphocholine micelles. Conformational changes are a key to antimicrobial activity.
The Journal of biological chemistry 2003;278(15):13110-7.
2003: Andrea Reipert; Kerstin Ehlert; Thomas Kast; Gabriele Bierbaum
Morphological and genetic differences in two isogenic Staphylococcus aureus strains with decreased susceptibilities to vancomycin.
Antimicrobial agents and chemotherapy 2003;47(2):568-76.
2002: Franziska Schaaff; Andrea Reipert; Gabriele Bierbaum
An elevated mutation frequency favors development of vancomycin resistance in Staphylococcus aureus.
Antimicrobial agents and chemotherapy 2002;46(11):3540-8.
2002: Florian Majer; Dietmar G Schmid; Karsten Altena; Gabriele Bierbaum; Thomas Kupke
The flavoprotein MrsD catalyzes the oxidative decarboxylation reaction involved in formation of the peptidoglycan biosynthesis inhibitor mersacidin.
Journal of bacteriology 2002;184(5):1234-43.
2002: André Guder; Tim Schmitter; Imke Wiedemann; Hans-Georg Sahl; Gabriele Bierbaum
Role of the single regulator MrsR1 and the two-component system MrsR2/K2 in the regulation of mersacidin production and immunity.
Applied and environmental microbiology 2002;68(1):106-13.
2001: H J Lee; J T Suh; Yeong Shik Kim; W Lenz; Gabriele Bierbaum; K P Schaal
Typing and antimicrobial susceptibilities of methicillin resistant Staphylococcus aureus (MRSA) strains isolated in a hospital in Korea.
Journal of Korean medical science 2001;16(4):381-5.
2001: Imke Wiedemann; Eefjan Breukink; C van Kraaij; Oscar P Kuipers; Gabriele Bierbaum; Ben de Kruijff; Hans-Georg Sahl
Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activity.
The Journal of biological chemistry 2001;276(3):1772-9.
2000: K Altena; André Guder; C Cramer; Gabriele Bierbaum
Biosynthesis of the lantibiotic mersacidin: organization of a type B lantibiotic gene cluster.
Applied and environmental microbiology 2000;66(6):2565-71.
2000: M Beukes; Gabriele Bierbaum; Hans-Georg Sahl; John W Hastings
Purification and partial characterization of a murein hydrolase, millericin B, produced by Streptococcus milleri NMSCC 061.
Applied and environmental microbiology 2000;66(1):23-8.
1999: Gabriele Bierbaum; K Fuchs; W Lenz; Christiane Szekat; Hans-Georg Sahl
Presence of Staphylococcus aureus with reduced susceptibility to vancomycin in Germany.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 1999;18(10):691-6.
1999: Ulrike Pag; C Heidrich; Gabriele Bierbaum; Hans-Georg Sahl
Molecular analysis of expression of the lantibiotic pep5 immunity phenotype.
Applied and environmental microbiology 1999;65(2):591-8.
1998: H Brötz; M Josten; Imke Wiedemann; U Schneider; Friedrich Götz; Gabriele Bierbaum; Hans-Georg Sahl
Role of lipid-bound peptidoglycan precursors in the formation of pores by nisin, epidermin and other lantibiotics.
Molecular microbiology 1998;30(2):317-27.
1998: C Heidrich; Ulrike Pag; M Josten; J Metzger; Ralph W Jack; Gabriele Bierbaum; G Jung; Hans-Georg Sahl
Isolation, characterization, and heterologous expression of the novel lantibiotic epicidin 280 and analysis of its biosynthetic gene cluster.
Applied and environmental microbiology 1998;64(9):3140-6.
1998: Hans-Georg Sahl; Gabriele Bierbaum
Lantibiotics: biosynthesis and biological activities of uniquely modified peptides from gram-positive bacteria.
Annual review of microbiology 1998;52():41-79.
1998: H Brötz; Gabriele Bierbaum; K Leopold; P E Reynolds; Hans-Georg Sahl
The lantibiotic mersacidin inhibits peptidoglycan synthesis by targeting lipid II.
Antimicrobial agents and chemotherapy 1998;42(1):154-60.
1997: H Brötz; Gabriele Bierbaum; P E Reynolds; Hans-Georg Sahl
The lantibiotic mersacidin inhibits peptidoglycan biosynthesis at the level of transglycosylation.
European journal of biochemistry / FEBS 1997;246(1):193-9.
1997: S Neis; Gabriele Bierbaum; M Josten; Ulrike Pag; C Kempter; G Jung; Hans-Georg Sahl
Effect of leader peptide mutations on biosynthesis of the lantibiotic Pep5.
FEMS microbiology letters 1997;149(2):249-55.
1996: Ernst Molitor; C Kluczny; H Brötz; Gabriele Bierbaum; R Jack; Hans-Georg Sahl
Effects of the lantibiotic mersacidin on the morphology of staphylococci.
Zentralblatt für Bakteriologie : international journal of medical microbiology 1996;284(2-3):318-28.
1996: C Heidrich; K Hantke; Gabriele Bierbaum; Hans-Georg Sahl
Identification and analysis of a gene encoding a Fur-like protein of Staphylococcus epidermidis.
FEMS microbiology letters 1996;140(2-3):253-9.
1996: Oscar P Kuipers; Gabriele Bierbaum; B Ottenwälder; Helen M Dodd; Nikki Horn; J Metzger; Thomas Kupke; V Gnau; R Bongers; P van den Bogaard; H Kosters; H S Rollema; WILLEM DE VOS; Roland Siezen; G Jung; Friedrich Götz; Hans-Georg Sahl; Michael J Gasson
Protein engineering of lantibiotics.
Antonie van Leeuwenhoek 1996;69(2):161-69.
1996: Gabriele Bierbaum; Friedrich Götz; Andreas Peschel; Thomas Kupke; M van de Kamp; Hans-Georg Sahl
The biosynthesis of the lantibiotics epidermin, gallidermin, Pep5 and epilancin K7.
Antonie van Leeuwenhoek 1996;69(2):119-127.
1996: Gabriele Bierbaum; C Szekat; M Josten; C Heidrich; C Kempter; G Jung; Hans-Georg Sahl
Engineering of a novel thioether bridge and role of modified residues in the lantibiotic Pep5.
Applied and environmental microbiology 1996;62(2):385-92.
1995: R Jack; Gabriele Bierbaum; C Heidrich; Hans-Georg Sahl
The genetics of lantibiotic biosynthesis.
BioEssays : news and reviews in molecular, cellular and developmental biology 1995;17(9):793-802.
1995: C Meyer; Gabriele Bierbaum; C Heidrich; M Reis; J Süling; M I Iglesias-Wind; C Kempter; Ernst Molitor; Hans-Georg Sahl
Nucleotide sequence of the lantibiotic Pep5 biosynthetic gene cluster and functional analysis of PepP and PepC. Evidence for a role of PepC in thioether formation.
European journal of biochemistry / FEBS 1995;232(2):478-89.
1995: Hans-Georg Sahl; R W Jack; Gabriele Bierbaum
Biosynthesis and biological activities of lantibiotics with unique post-translational modifications.
European journal of biochemistry / FEBS 1995;230(3):827-53.
1995: M van de Kamp; H W van den Hooven; RN Konings; Gabriele Bierbaum; Hans-Georg Sahl; Oscar P Kuipers; Roland Siezen; WILLEM DE VOS; Cornelis W Hilbers; F J van de Ven
Elucidation of the primary structure of the lantibiotic epilancin K7 from Staphylococcus epidermidis K7. Cloning and characterisation of the epilancin-K7-encoding gene and NMR analysis of mature epilancin K7.
European journal of biochemistry / FEBS 1995;230(2):587-600.
1995: Gabriele Bierbaum; H Brötz; K P Koller; Hans-Georg Sahl
Cloning, sequencing and production of the lantibiotic mersacidin.
FEMS microbiology letters 1995;127(1-2):121-6.
1995: H Brötz; Gabriele Bierbaum; A Markus; Ernst Molitor; Hans-Georg Sahl
Mode of action of the lantibiotic mersacidin: inhibition of peptidoglycan biosynthesis via a novel mechanism?
Antimicrobial agents and chemotherapy 1995;39(3):714-9.
1994: Gabriele Bierbaum; M Reis; C Szekat; Hans-Georg Sahl
Construction of an expression system for engineering of the lantibiotic Pep5.
Applied and environmental microbiology 1994;60(12):4332-8.
1993: Gabriele Bierbaum; Hans-Georg Sahl
Lantibiotics--unusually modified bacteriocin-like peptides from gram-positive bacteria.
Zentralblatt für Bakteriologie : international journal of medical microbiology 1993;278(1):1-22.
1989: Gabriele Bierbaum; Hans-Georg Sahl
Influence of cationic peptides on the activity of the autolytic endo-beta-N-acetylglucosaminidase of Staphylococcus simulans 22.
FEMS microbiology letters 1989;49(2-3):223-7.
1987: Hans-Georg Sahl; H Ersfeld-Dressen; Gabriele Bierbaum; M Josten; M Kordel; M Reis; F Schüller
Different mechanisms of insensitivity to the staphylococcin-like peptide Pep 5.
Zentralblatt für Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology 1987;267(2):173-85.
1987: Gabriele Bierbaum; Hans-Georg Sahl
Autolytic system of Staphylococcus simulans 22: influence of cationic peptides on activity of N-acetylmuramoyl-L-alanine amidase.
Journal of bacteriology 1987;169(12):5452-8.
1985: Gabriele Bierbaum; Hans-Georg Sahl
Induction of autolysis of staphylococci by the basic peptide antibiotics Pep 5 and nisin and their influence on the activity of autolytic enzymes.
Archives of microbiology 1985;141(3):249-54.