FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Mark Roe

Research Profile

Concepts & Ideas

Procedures

Chemicals & Drugs

Genes & Molecular Sequences

Amino Acid Sequences

Phenomena

Living Beings

Archaeoglobus fulgidus

Physiology

Protein Folding

Co-author Network

Publications

TOP 3
Russell R A Kitson; William Lewis; Chuan-Hsin Chang; Adrienne L Davis; Donna L Dehn; Chrisostomos Prodromou; S Mark Roe; David Ross; David Siegel; Huw E L Williams; Rui Xiong; Christopher J Moody
Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90.
Swee Y Sharp; Paul Workman; S Mark Roe; Inga Cikotienė; Egidijus Kazlauskas; Daumantas Matulis; Chrisostomos Prodromou
Co-crystalization and in vitro biological characterization of 5-aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors.
Stefan H Millson; Laurence H Pearl; Chun-Song Chua; Sigrun Polier; Chrisostomos Prodromou; S Mark Roe; Tiow-Suan Sim; Svetlana Solovieva; Peter W Piper
Features of the Streptomyces hygroscopicus HtpG reveal how partial geldanamycin resistance can arise with mutation to the ATP binding pocket of a eukaryotic Hsp90.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Mark Roe (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Russell R A Kitson; William Lewis; Chuan-Hsin Chang; Adrienne L Davis; Donna L Dehn; Chrisostomos Prodromou; S Mark Roe; David Ross; David Siegel; Huw E L Williams; Rui Xiong; Christopher J Moody
Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90.
Nature chemistry 2013;5(4):307-14.
2012: Swee Y Sharp; Paul Workman; S Mark Roe; Inga Cikotienė; Egidijus Kazlauskas; Daumantas Matulis; Chrisostomos Prodromou
Co-crystalization and in vitro biological characterization of 5-aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors.
PloS one 2012;7(9):e44642.
2011: Stefan H Millson; Laurence H Pearl; Chun-Song Chua; Sigrun Polier; Chrisostomos Prodromou; S Mark Roe; Tiow-Suan Sim; Svetlana Solovieva; Peter W Piper
Features of the Streptomyces hygroscopicus HtpG reveal how partial geldanamycin resistance can arise with mutation to the ATP binding pocket of a eukaryotic Hsp90.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(11):3828-37.
2011: Carien Dekker; Elizabeth A McCormack; Laurence H Pearl; S Mark Roe; Fabienne Beuron; Keith R Willison
The crystal structure of yeast CCT reveals intrinsic asymmetry of eukaryotic cytosolic chaperonins.
The EMBO journal 2011;30(15):3078-90.
2010: James E H Day; Swee Y Sharp; Martin G Rowlands; Wynne Aherne; William Lewis; S Mark Roe; Chrisostomos Prodromou; Laurence H Pearl; Paul Workman; Christopher J Moody
Inhibition of Hsp90 with resorcylic acid macrolactones: synthesis and binding studies.
Chemistry (Weinheim an der Bergstrasse, Germany) 2010;16(34):10366-72.
2010: Ziguo Zhang; S Mark Roe; Marie Diogon; Eric Kong; Hicham El Alaoui; David Barford
Molecular structure of the N-terminal domain of the APC/C subunit Cdc27 reveals a homo-dimeric tetratricopeptide repeat architecture.
Journal of molecular biology 2010;397(5):1316-28.
2010: Mark W Richards; Justin W C Leung; S Mark Roe; Kaiyi Li; Junjie Chen; Richard Bayliss
A pocket on the surface of the N-terminal BRCT domain of Mcph1 is required to prevent abnormal chromosome condensation.
Journal of molecular biology 2010;395(5):908-15.
2009: Jing Yang; Ziguo Zhang; S Mark Roe; Christopher J Marshall; David Barford
Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor.
Science (New York, N.Y.) 2009;325(5946):1398-402.
2009: Tom D Bunney; Olaniyi Opaleye; S Mark Roe; Petra Vatter; Rhona W Baxendale; Claudia Walliser; Katy L Everett; Michelle Josephs; Carolin Christow; Fernando Rodrigues-Lima; Peter Gierschik; Laurence H Pearl; Matilda Katan
Structural insights into formation of an active signaling complex between Rac and phospholipase C gamma 2.
Molecular cell 2009;34(2):223-33.
2009: Chrisostomos Prodromou; James M Nuttall; Stefan H Millson; S Mark Roe; Tiow-Suan Sim; Doreen Tan; Paul Workman; Laurence H Pearl; Peter W Piper
Structural basis of the radicicol resistance displayed by a fungal hsp90.
ACS chemical biology 2009;4(4):289-97.
2009: James S Parker; Eneida A Parizotto; Muhan Wang; S Mark Roe; David Barford
Enhancement of the seed-target recognition step in RNA silencing by a PIWI/MID domain protein.
Molecular cell 2009;33(2):204-14.
2009: Stacey M Southall; Poon-Sheng Wong; Zain Odho; S Mark Roe; Jon R Wilson
Structural basis for the requirement of additional factors for MLL1 SET domain activity and recognition of epigenetic marks.
Molecular cell 2009;33(2):181-91.
2008: Mairi L Kilkenny; Andrew S Doré; S Mark Roe; Konstantinos Nestoras; Jenny C Y Ho; Felicity Z Watts; Laurence H Pearl
Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair.
Genes & development 2008;22(15):2034-47.
2007: Jing Yang; S Mark Roe; Todd D Prickett; David L Brautigan; David Barford
The structure of Tap42/alpha4 reveals a tetratricopeptide repeat-like fold and provides insights into PP2A regulation.
Biochemistry 2007;46(30):8807-15.
2007: Swee Y Sharp; Kathy Boxall; Martin G Rowlands; Chrisostomos Prodromou; S Mark Roe; Alison Maloney; Marissa Powers; Paul A Clarke; Gary Box; Sharon Sanderson; Lisa Patterson; Thomas P Matthews; Kwai-Ming J Cheung; Karen Ball; Angela Hayes; Florence I Raynaud; Richard Marais; Laurence H Pearl; Suzanne A Eccles; Wynne Aherne; Edward McDonald; Paul Workman
In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors.
Cancer research 2007;67(5):2206-16.
2007: Jing Yang; Arnoud Groen; Simone Lemeer; Anne Jans; Monique Slijper; S Mark Roe; Jeroen den Hertog; David Barford
Reversible oxidation of the membrane distal domain of receptor PTPalpha is mediated by a cyclic sulfenamide.
Biochemistry 2007;46(3):709-19.
2006: Nicolas Proisy; Swee Y Sharp; Kathy Boxall; Stephen Connelly; S Mark Roe; Chrisostomos Prodromou; Alexandra M Z Slawin; Laurence H Pearl; Paul Workman; Christopher J Moody
Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol.
Chemistry & biology 2006;13(11):1203-15.
2006: Barbara H Jennings; Laura M Pickles; S Mark Wainwright; S Mark Roe; Laurence H Pearl; David Ish-Horowicz
Molecular recognition of transcriptional repressor motifs by the WD domain of the Groucho/TLE corepressor.
Molecular cell 2006;22(5):645-55.
2006: Maruf M U Ali; S Mark Roe; Cara K Vaughan; Phillipe Meyer; Barry Panaretou; Peter W Piper; Chrisostomos Prodromou; Laurence H Pearl
Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex.
Nature 2006;440(7087):1013-7.
2006: James S Parker; S Mark Roe; David Barford
Molecular mechanism of target RNA transcript recognition by Argonaute-guide complexes.
Cold Spring Harbor symposia on quantitative biology 2006;71():45-50.
2006: Andrew S Doré; Mairi L Kilkenny; Sarah A Jones; Antony Oliver; S Mark Roe; Steve Bell; Laurence H Pearl
Structure of an archaeal PCNA1-PCNA2-FEN1 complex: elucidating PCNA subunit and client enzyme specificity.
Nucleic acids research 2006;34(16):4515-26.
2005: Minghao Zhang; Mark Windheim; S Mark Roe; Mark Peggie; Philip Cohen; Chrisostomos Prodromou; Laurence H Pearl
Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex.
Molecular cell 2005;20(4):525-38.
2005: Antony Oliver; Sarah A Jones; S Mark Roe; Steve Matthews; Graham H Goodwin; Laurence H Pearl
Crystal structure of the proximal BAH domain of the polybromo protein.
The Biochemical journal 2005;389(Pt 3):657-64.
2005: Kwai-Ming J Cheung; Thomas P Matthews; Karen James; Martin G Rowlands; Kathy Boxall; Swee Y Sharp; Alison Maloney; S Mark Roe; Chrisostomos Prodromou; Laurence H Pearl; G Wynne Aherne; Edward McDonald; Paul Workman
The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(14):3338-43.
2005: James S Parker; S Mark Roe; David Barford
Structural insights into mRNA recognition from a PIWI domain-siRNA guide complex.
Nature 2005;434(7033):663-6.
2005: Jing Yang; S Mark Roe; Matthew J Cliff; Mark A Williams; John E Ladbury; Patricia T W Cohen; David Barford
Molecular basis for TPR domain-mediated regulation of protein phosphatase 5.
The EMBO journal 2005;24(1):1-10.
2004: James S Parker; S Mark Roe; David Barford
Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity.
The EMBO journal 2004;23(24):4727-37.
2004: Philippe Meyer; Chrisostomos Prodromou; Chunyan Liao; Bin Hu; S Mark Roe; Cara K Vaughan; Ignacija Vlasic; Barry Panaretou; Peter W Piper; Laurence H Pearl
Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery.
The EMBO journal 2004;23(6):1402-10.
2004: Paul T C Wan; Mathew J Garnett; S Mark Roe; Sharlene Lee; Dan Niculescu-Duvaz; Valerie M Good; C Michael Jones; Christopher J Marshall; Caroline J Springer; David Barford; Richard Marais
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF.
Cell 2004;116(6):855-67.
2004: Panagiotis Polychronopoulos; Prokopios Magiatis; Alexios-Leandros Skaltsounis; vassilios myrianthopoulos; Emmanuel Mikros; Aldo Tarricone; Andrea Musacchio; S Mark Roe; Laurence H Pearl; Maryse Leost; Paul Greengard; Laurent Meijer
Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases.
Journal of medicinal chemistry 2004;47(4):935-46.
2004: S Mark Roe; Maruf M U Ali; Philippe Meyer; Cara K Vaughan; Barry Panaretou; Peter W Piper; Chrisostomos Prodromou; Laurence H Pearl
The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37).
Cell 2004;116(1):87-98.
2004: Antony Oliver; Jean-Christophe Amé; S Mark Roe; Valerie M Good; Gilbert de Murcia; Laurence H Pearl
Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2.
Nucleic acids research 2004;32(2):456-64.
2003: Laurent Meijer; Alexios-Leandros Skaltsounis; Prokopios Magiatis; Panagiotis Polychronopoulos; Marie Knockaert; Maryse Leost; Xiaozhou P Ryan; Claudia Alin Vonica; Ali H Brivanlou; Rana Dajani; Claudia Crovace; Cataldo Tarricone; Andrea Musacchio; S Mark Roe; Laurence H Pearl; Paul Greengard
GSK-3-selective inhibitors derived from Tyrian purple indirubins.
Chemistry & biology 2003;10(12):1255-66.
2003: Karen A Bunting; S Mark Roe; Laurence H Pearl
Structural basis for recruitment of translesion DNA polymerase Pol IV/DinB to the beta-clamp.
The EMBO journal 2003;22(21):5883-92.
2003: Xiaoxuan Zhang; S Mark Roe; Yanwen Hou; Mark Bartlam; Zihe Rao; Laurence H Pearl; Christopher J Danpure
Crystal structure of alanine:glyoxylate aminotransferase and the relationship between genotype and enzymatic phenotype in primary hyperoxaluria type 1.
Journal of molecular biology 2003;331(3):643-52.
2003: Karen A Bunting; S Mark Roe; Anthony Headley; Tom Brown; Renos Savva; Laurence H Pearl
Crystal structure of the Escherichia coli dcm very-short-patch DNA repair endonuclease bound to its reaction product-site in a DNA superhelix.
Nucleic acids research 2003;31(6):1633-9.
2003: Philippe Meyer; Chrisostomos Prodromou; Bin Hu; Cara Vaughan; S Mark Roe; Barry Panaretou; Peter W Piper; Laurence H Pearl
Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions.
Molecular cell 2003;11(3):647-58.
2003: Rana Dajani; Elizabeth Fraser; S Mark Roe; Margaret Yeo; Valerie M Good; Vivienne Thompson; Trevor C Dale; Laurence H Pearl
Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex.
The EMBO journal 2003;22(3):494-501.
2002: Laura M Pickles; S Mark Roe; Elizabeth J Hemingway; Stefano Stifani; Laurence H Pearl
Crystal structure of the C-terminal WD40 repeat domain of the human Groucho/TLE1 transcriptional corepressor.
Structure (London, England : 1993) 2002;10(6):751-61.
2002: Günter Pappenberger; Julie A Wilsher; S Mark Roe; Damian J Counsell; Keith R Willison; Laurence H Pearl
Crystal structure of the CCTgamma apical domain: implications for substrate binding to the eukaryotic cytosolic chaperonin.
Journal of molecular biology 2002;318(5):1367-79.
2001: Xiaoxuan Zhang; S Mark Roe; Laurence H Pearl; Christopher J Danpure
Crystallization and preliminary crystallographic analysis of human alanine:glyoxylate aminotransferase and its polymorphic variants.
Acta crystallographica. Section D, Biological crystallography 2001;57(Pt 12):1936-7.
2001: Rana Dajani; Elizabeth Fraser; S Mark Roe; Neville Young; Valerie M Good; Trevor C Dale; Laurence H Pearl
Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition.
Cell 2001;105(6):721-32.
2000: Chrisostomos Prodromou; Barry Panaretou; S Chohan; Giuliano Siligardi; Ronan O'Brien; John E Ladbury; S Mark Roe; Peter W Piper; Laurence H Pearl
The ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the N-terminal domains.
The EMBO journal 2000;19(16):4383-92.
2000: Bernard O'Hara; S A Wilson; A W Lee; S Mark Roe; Giuliano Siligardi; RE Drew; Laurence H Pearl
Structural adaptation to selective pressure for altered ligand specificity in the Pseudomonas aeruginosa amide receptor, amiC.
Protein engineering 2000;13(2):129-32.
1999: Bernard O'Hara; Ryan A Norman; P T Wan; S Mark Roe; Tracey E Barrett; RE Drew; Laurence H Pearl
Crystal structure and induction mechanism of AmiC-AmiR: a ligand-regulated transcription antitermination complex.
The EMBO journal 1999;18(19):5175-86.
1999: S Mark Roe; Chrisostomos Prodromou; Ronan O'Brien; John E Ladbury; Peter W Piper; Laurence H Pearl
Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin.
Journal of medicinal chemistry 1999;42(2):260-6.
1998: S Mark Roe; T Barlow; Tom Brown; M Oram; Anthony Keeley; Irina R Tsaneva; Laurence H Pearl
Crystal structure of an octameric RuvA-Holliday junction complex.
Molecular cell 1998;2(3):361-72.
1998: Barry Panaretou; Chrisostomos Prodromou; S Mark Roe; Ronan O'Brien; John E Ladbury; Peter W Piper; Laurence H Pearl
ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo.
The EMBO journal 1998;17(16):4829-36.
1997: Chrisostomos Prodromou; S Mark Roe; Ronan O'Brien; John E Ladbury; Peter W Piper; Laurence H Pearl
Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone.
Cell 1997;90(1):65-75.
1997: Chrisostomos Prodromou; S Mark Roe; Peter W Piper; Laurence H Pearl
A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone.
Nature structural biology 1997;4(6):477-82.