Angelika Bierhaus

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Signal Transduction

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Schlotterer Andreas; Kukudov Georgi; Bozorgmehr Farastuk; Hutter Harald; Du Xueliang; Oikonomou Dimitrios; Ibrahim Youssef; Pfisterer Friederike; Rabbani Naila; Thornalley Paul; Sayed Ahmed; Fleming Thomas; Humpert Per; Schwenger Vedat; Zeier Martin; Hamann Andreas; Stern David; Brownlee Michael; Bierhaus Angelika; Nawroth Peter; Morcos Michael
C. elegans as model for the study of high glucose- mediated life span reduction.
Bierhaus A; Nawroth P P
Multiple levels of regulation determine the role of the receptor for AGE (RAGE) as common soil in inflammation, immune responses and diabetes mellitus and its complications.
Seehaus Stefanie; Shahzad Khurrum; Kashif Muhammed; Vinnikov Ilya A; Schiller Martin; Wang Hongjie; Madhusudhan Thati; Eckstein Volker; Bierhaus Angelika; Bea Florian; Blessing Erwin; Weiler Hartmut; Frommhold David; Nawroth Peter P; Isermann Berend
Hypercoagulability inhibits monocyte transendothelial migration through protease-activated receptor-1-, phospholipase-Cbeta-, phosphoinositide 3-kinase-, and nitric oxide-dependent signaling in monocytes and promotes plaque stability.

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All Publications

2009: Schlotterer Andreas; Kukudov Georgi; Bozorgmehr Farastuk; Hutter Harald; Du Xueliang; Oikonomou Dimitrios; Ibrahim Youssef; Pfisterer Friederike; Rabbani Naila; Thornalley Paul; Sayed Ahmed; Fleming Thomas; Humpert Per; Schwenger Vedat; Zeier Martin; Hamann Andreas; Stern David; Brownlee Michael; Bierhaus Angelika; Nawroth Peter; Morcos Michael
C. elegans as model for the study of high glucose- mediated life span reduction.
Diabetes 2009;58(11):2450-6.
2009: Bierhaus A; Nawroth P P
Multiple levels of regulation determine the role of the receptor for AGE (RAGE) as common soil in inflammation, immune responses and diabetes mellitus and its complications.
Diabetologia 2009;52(11):2251-63.
2009: Seehaus Stefanie; Shahzad Khurrum; Kashif Muhammed; Vinnikov Ilya A; Schiller Martin; Wang Hongjie; Madhusudhan Thati; Eckstein Volker; Bierhaus Angelika; Bea Florian; Blessing Erwin; Weiler Hartmut; Frommhold David; Nawroth Peter P; Isermann Berend
Hypercoagulability inhibits monocyte transendothelial migration through protease-activated receptor-1-, phospholipase-Cbeta-, phosphoinositide 3-kinase-, and nitric oxide-dependent signaling in monocytes and promotes plaque stability.
Circulation 2009;120(9):774-84.
2009: van Zoelen Marieke A D; Schmidt Ann-Marie; Florquin Sandrine; Meijers Joost C; de Beer Regina; de Vos Alex F; Nawroth Peter P; Bierhaus Angelika; van der Poll Tom
Receptor for advanced glycation end products facilitates host defense during Escherichia coli-induced abdominal sepsis in mice.
The Journal of infectious diseases 2009;200(5):765-73.
2009: van Zoelen Marieke A D; van der Sluijs Koenraad F; Achouiti Ahmed; Florquin Sandrine; Braun-Pater Jennie M; Yang Huan; Nawroth Peter P; Tracey Kevin J; Bierhaus Angelika; van der Poll Tom
Receptor for advanced glycation end products is detrimental during influenza A virus pneumonia.
Virology 2009;391(2):265-73.
2009: von Eynatten Maximilian; Liu Dan; Hock Cornelia; Oikonomou Dimitrios; Baumann Marcus; Allolio Bruno; Korosoglou Grigorios; Morcos Michael; Campean Valentina; Amann Kerstin; Lutz Jens; Heemann Uwe; Nawroth Peter P; Bierhaus Angelika; Humpert Per M
Urinary adiponectin excretion: a novel marker for vascular damage in type 2 diabetes.
Diabetes 2009;58(9):2093-9.
2009: Humpert Per M; Lukic Ivan K; Thorpe Suzanne R; Hofer Stefan; Awad Ezzat M; Andrassy Martin; Deemer Elizabeth K; Kasper Michael; Schleicher Erwin; Schwaninger Markus; Weigand Markus A; Nawroth Peter P; Bierhaus Angelika
AGE-modified albumin containing infusion solutions boosts septicaemia and inflammation in experimental peritonitis.
Journal of leukocyte biology 2009;86(3):589-97.
2009: Wolf Jutta M; Rohleder Nicolas; Bierhaus Angelika; Nawroth Peter P; Kirschbaum Clemens
Determinants of the NF-kappaB response to acute psychosocial stress in humans.
Brain, behavior, and immunity 2009;23(6):742-9.
2009: von Eynatten M; Liu D; Bluemm A; Schuster T; Baumann M; Lutz J; Heemann U; Dugi K A; Nawroth P P; Bierhaus A; Humpert P M
Changes in adiponectin multimer distribution in response to atorvastatin treatment in patients with type 2 diabetes.
Clinical endocrinology 2009;71(1):27-32.
2009: Yan Shi Du; Bierhaus Angelika; Nawroth Peter P; Stern David M
Endothelial precursor cells and CRP on the RAGE: activation or cell death?
Journal of cardiovascular pharmacology 2009;53(5):349-51.
2009: Yan Shi Du; Bierhaus Angelika; Nawroth Peter P; Stern David M
RAGE and Alzheimer's disease: a progression factor for amyloid-beta-induced cellular perturbation?
Journal of Alzheimer's disease : JAD 2009;16(4):833-43.
2009: Muhammad Sajjad; Bierhaus Angelika; Schwaninger Markus
Reactive oxygen species in diabetes-induced vascular damage, stroke, and Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2009;16(4):775-85.
2009: Bierhaus Angelika; Nawroth Peter P
The Alzheimer's disease-diabetes angle: inevitable fate of aging or metabolic imbalance limiting successful aging. Preface.
Journal of Alzheimer's disease : JAD 2009;16(4):673-5.
2009: Hartog Jasper W L; Gross Sascha; Oterdoom Leendert H; van Ree Rutger M; de Vries Aiko P J; Smit Andries J; Schouten Jan P; Nawroth Peter P; Gans Reinold O B; van Son Willem J; Bierhaus Angelika; Bakker Stephan J L
Skin-autofluorescence is an independent predictor of graft loss in renal transplant recipients.
Transplantation 2009;87(7):1069-77.
2009: van Zoelen Marieke A D; Schouten Marcel; de Vos Alex F; Florquin Sandrine; Meijers Joost C M; Nawroth Peter P; Bierhaus Angelika; van der Poll Tom
The receptor for advanced glycation end products impairs host defense in pneumococcal pneumonia.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(7):4349-56.
2009: Coughlan Melinda T; Thorburn David R; Penfold Sally A; Laskowski Adrienne; Harcourt Brooke E; Sourris Karly C; Tan Adeline L Y; Fukami Kei; Thallas-Bonke Vicki; Nawroth Peter P; Brownlee Michael; Bierhaus Angelika; Cooper Mark E; Forbes Josephine M
RAGE-induced cytosolic ROS promote mitochondrial superoxide generation in diabetes.
Journal of the American Society of Nephrology : JASN 2009;20(4):742-52.
2009: Rudofsky G; Schlotterer A; Reismann P; Engel J; Grafe I A; Tafel J; Morcos M; Humpert P M; Nawroth P; Bierhaus A; Hamann A
The -174G>C IL-6 gene promoter polymorphism and diabetic microvascular complications.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2009;41(4):308-13.
2009: van Zoelen Marieke A D; Yang Huan; Florquin Sandrine; Meijers Joost C M; Akira Shizuo; Arnold Bernd; Nawroth Peter P; Bierhaus Angelika; Tracey Kevin J; van der Poll Tom
Role of toll-like receptors 2 and 4, and the receptor for advanced glycation end products in high-mobility group box 1-induced inflammation in vivo.
Shock (Augusta, Ga.) 2009;31(3):280-4.
2009: Humpert Per M; Morcos Michael; Oikonomou Dimitrios; Schaefer Karin; Hamann Andreas; Bierhaus Angelika; Schilling Tobias; Nawroth Peter P
External electric muscle stimulation improves burning sensations and sleeping disturbances in patients with type 2 diabetes and symptomatic neuropathy.
Pain medicine (Malden, Mass.) 2009;10(2):413-9.
2009: Hofer Stefan; Steppan Jochen; Wagner Tanja; Funke Benjamin; Lichtenstern Christoph; Martin Eike; Graf Bernhard M; Bierhaus Angelika; Weigand Markus A
Central sympatholytics prolong survival in experimental sepsis.
Critical care (London, England) 2009;13(1):R11.
2008: Muhammad Sajjad; Barakat Waleed; Stoyanov Stoyan; Murikinati Sasidhar; Yang Huan; Tracey Kevin J; Bendszus Martin; Rossetti Grazisa; Nawroth Peter P; Bierhaus Angelika; Schwaninger Markus
The HMGB1 receptor RAGE mediates ischemic brain damage.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(46):12023-31.
2008: Morcos M; Schlotterer A; Sayed A A R; Kukudov G; Oikomonou D; Ibrahim Y; Pfisterer F; Schneider J; Bozorgmehr F; Rudofsky G; Schwenger V; Kientsch-Engels R; Hamann A; Zeier M; Dugi K; Yard B; Humpert P M; van der Woude F; Nawroth P P; Bierhaus A
Rosiglitazone reduces angiotensin II and advanced glycation end product-dependent sustained nuclear factor-kappaB activation in cultured human proximal tubular epithelial cells.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2008;40(11):752-9.
2008: Buchbinder S; Bierhaus A; Zorn M; Nawroth P P; Humpert P; Schilling T
Aryl hydrocarbon receptor interacting protein gene (AIP) mutations are rare in patients with hormone secreting or non-secreting pituitary adenomas.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2008;116(10):625-8.
2008: Turovskaya Olga; Foell Dirk; Sinha Pratima; Vogl Thomas; Newlin Robbin; Nayak Jonamani; Nguyen Mien; Olsson Anna; Nawroth Peter P; Bierhaus Angelika; Varki Nissi; Kronenberg Mitchell; Freeze Hudson H; Srikrishna Geetha
RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis.
Carcinogenesis 2008;29(10):2035-43.
2008: Raucci Angela; Cugusi Simona; Antonelli Antonella; Barabino Silvia M; Monti Lucilla; Bierhaus Angelika; Reiss Karina; Saftig Paul; Bianchi Marco E
A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10).
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(10):3716-27.
2008: Kihm Lars P; Wibisono Dennis; Müller-Krebs Sandra; Pfisterer Friederike; Morath Christian; Gross Marie L; Morcos Michael; Seregin Yuri; Bierhaus Angelika; Nawroth Peter P; Zeier Martin; Schwenger Vedat
RAGE expression in the human peritoneal membrane.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2008;23(10):3302-6.
2008: Soro-Paavonen Aino; Watson Anna M D; Li Jiaze; Paavonen Karri; Koitka Audrey; Calkin Anna C; Barit David; Coughlan Melinda T; Drew Brian G; Lancaster Graeme I; Thomas Merlin; Forbes Josephine M; Nawroth Peter P; Bierhaus Angelika; Cooper Mark E; Jandeleit-Dahm Karin A
Receptor for advanced glycation end products (RAGE) deficiency attenuates the development of atherosclerosis in diabetes.
Diabetes 2008;57(9):2461-9.
2008: Tikellis Christos; Thomas Merlin C; Harcourt Brooke E; Coughlan Melinda T; Pete Josepha; Bialkowski Katarzyna; Tan Adeline; Bierhaus Angelika; Cooper Mark E; Forbes Josephine M
Cardiac inflammation associated with a Western diet is mediated via activation of RAGE by AGEs.
American journal of physiology. Endocrinology and metabolism 2008;295(2):E323-30.
2008: von Eynatten Maximilian; Humpert Per M; Bluemm Annabelle; Lepper Philipp M; Hamann Andreas; Allolio Bruno; Nawroth Peter P; Bierhaus Angelika; Dugi Klaus A
High-molecular weight adiponectin is independently associated with the extent of coronary artery disease in men.
Atherosclerosis 2008;199(1):123-8.
2008: Andrassy Martin; Volz Hans C; Igwe John C; Funke Benjamin; Eichberger Sebastian N; Kaya Ziya; Buss Sebastian; Autschbach Frank; Pleger Sven T; Lukic Ivan K; Bea Florian; Hardt Stefan E; Humpert Per M; Bianchi Marco E; Mairbäurl Heimo; Nawroth Peter P; Remppis Andrew; Katus Hugo A; Bierhaus Angelika
High-mobility group box-1 in ischemia-reperfusion injury of the heart.
Circulation 2008;117(25):3216-26.
2008: Bopp Christian; Hofer Stefan; Weitz Jürgen; Bierhaus Angelika; Nawroth Peter P; Martin Eike; Büchler Markus W; Weigand Markus A
sRAGE is elevated in septic patients and associated with patients outcome.
The Journal of surgical research 2008;147(1):79-83.
2008: Humpert Per M; Oikonomou Dimitrios; Morcos Michael; Kuecherer Helmut; Schilling Tobias; Bierhaus Angelika; Nawroth Peter P; Katus Hugo A; Korosoglou Grigorios
Impact of autonomic neuropathy on left ventricular function in normotensive type 1 diabetic patients: a tissue Doppler echocardiographic study: response to Karamitsos et al.
Diabetes care 2008;31(5):e40; author reply e41.
2008: Haase Michael G; Klawitter Anke; Bierhaus Angelika; Yokoyama Kazunari K; Kasper Michael; Geyer Peter; Baumann Michael; Baretton Gustavo B
Inactivation of AP1 proteins by a nuclear serine protease precedes the onset of radiation-induced fibrosing alveolitis.
Radiation research 2008;169(5):531-42.
2008: Humpert Per M; Djuric Zdenka; Zeuge Ulf; Oikonomou Dimitrios; Seregin Yuri; Laine Klaus; Eckstein Volker; Nawroth Peter P; Bierhaus Angelika
Insulin stimulates the clonogenic potential of angiogenic endothelial progenitor cells by IGF-1 receptor-dependent signaling.
Molecular medicine (Cambridge, Mass.) 2008;14(5-6):301-8.
2008: Lukic Ivan K; Humpert Per M; Nawroth Peter P; Bierhaus Angelika
The RAGE pathway: activation and perpetuation in the pathogenesis of diabetic neuropathy.
Annals of the New York Academy of Sciences 2008;1126():76-80.
2008: Wang Yumei; Vom Hagen Franziska; Pfister Frederick; Bierhaus Angelika; Feng Yuxi; Gans Reinhold; Hammes Hans-Peter
Receptor for advanced glycation end product expression in experimental diabetic retinopathy.
Annals of the New York Academy of Sciences 2008;1126():42-5.
2008: Buchbinder S; Rudofsky G; Humpert P M; Schilling T; Zorn M; Bierhaus A; Nawroth P P
The DG10S478 variant in the TCF7L2 gene is not associated with microvascular complications in type 2 diabetes.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2008;116(4):211-4.
2008: Englert Judson M; Hanford Lana E; Kaminski Naftali; Tobolewski Jacob M; Tan Roderick J; Fattman Cheryl L; Ramsgaard Lasse; Richards Thomas J; Loutaev Inna; Nawroth Peter P; Kasper Michael; Bierhaus Angelika; Oury Tim D
A role for the receptor for advanced glycation end products in idiopathic pulmonary fibrosis.
The American journal of pathology 2008;172(3):583-91.
2008: Morcos Michael; Du Xueliang; Pfisterer Friederike; Hutter Harald; Sayed Ahmed A R; Thornalley Paul; Ahmed Naila; Baynes John; Thorpe Suzanne; Kukudov Georgi; Schlotterer Andreas; Bozorgmehr Farastuk; El Baki Randa Abd; Stern David; Moehrlen Frank; Ibrahim Youssef; Oikonomou Dimitrios; Hamann Andreas; Becker Christian; Zeier Martin; Schwenger Vedat; Miftari Nexhat; Humpert Per; Hammes Hans-Peter; Buechler Markus; Bierhaus Angelika; Brownlee Michael; Nawroth Peter P
Glyoxalase-1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans.
Aging cell 2008;7(2):260-9.
2008: Manfredi Angelo A; Capobianco Annalisa; Esposito Antonio; De Cobelli Francesco; Canu Tamara; Monno Antonella; Raucci Angela; Sanvito Francesca; Doglioni Claudio; Nawroth Peter P; Bierhaus Angelika; Bianchi Marco E; Rovere-Querini Patrizia; Del Maschio Alessandro
Maturing dendritic cells depend on RAGE for in vivo homing to lymph nodes.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(4):2270-5.
2008: Gebhardt Christoffer; Riehl Astrid; Durchdewald Moritz; Németh Julia; Fürstenberger Gerhard; Müller-Decker Karin; Enk Alexander; Arnold Bernd; Bierhaus Angelika; Nawroth Peter P; Hess Jochen; Angel Peter
RAGE signaling sustains inflammation and promotes tumor development.
The Journal of experimental medicine 2008;205(2):275-85.
2008: Hofer Stefan; Eisenbach Christoph; Lukic Ivan K; Schneider Lutz; Bode Konrad; Brueckmann Martina; Mautner Sven; Wente Moritz N; Encke Jens; Werner Jens; Dalpke Alexander H; Stremmel Wolfgang; Nawroth Peter P; Martin Eike; Krammer Peter H; Bierhaus Angelika; Weigand Markus A
Pharmacologic cholinesterase inhibition improves survival in experimental sepsis.
Critical care medicine 2008;36(2):404-8.
2008: Rudofsky G; Schlotterer A; Humpert P M; Tafel J; Morcos M; Nawroth P P; Bierhaus A; Hamann A
A M55V polymorphism in the SUMO4 gene is associated with a reduced prevalence of diabetic retinopathy in patients with Type 1 diabetes.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2008;116(1):14-7.
2008: Bopp Christian; Bierhaus Angelika; Hofer Stefan; Bouchon Axel; Nawroth Peter P; Martin Eike; Weigand Markus A
Bench-to-bedside review: The inflammation-perpetuating pattern-recognition receptor RAGE as a therapeutic target in sepsis.
Critical care (London, England) 2008;12(1):201.
2007: Humpert P M; Papadopoulos G; Schaefer K; Djuric Z; Konrade I; Morcos M; Nawroth P P; Bierhaus A
sRAGE and esRAGE are not associated with peripheral or autonomic neuropathy in type 2 diabetes.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2007;39(12):899-902.
2007: Isermann Berend; Vinnikov Ilya A; Madhusudhan Thati; Herzog Stefanie; Kashif Muhammed; Blautzik Janusch; Corat Marcus A F; Zeier Martin; Blessing Erwin; Oh Jun; Gerlitz Bruce; Berg David T; Grinnell Brian W; Chavakis Triantafyllos; Esmon Charles T; Weiler Hartmut; Bierhaus Angelika; Nawroth Peter P
Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis.
Nature medicine 2007;13(11):1349-58.
2007: Gross Sascha; van Ree Rutger M; Oterdoom Leendert H; de Vries Aiko P J; van Son Willem J; de Jong Paul E; Navis Gerjan J; Zuurman Mike W; Bierhaus Angelika; Gans Rijk O B; Bakker Stephan J L
Low levels of sRAGE are associated with increased risk for mortality in renal transplant recipients.
Transplantation 2007;84(5):659-63.
2007: Rudofsky G; Reismann P; Grafe I A; Konrade I; Djuric Z; Tafel J; Buchbinder S; Zorn M; Humpert P M; Hamann A; Morcos M; Nawroth P P; Bierhaus A
Improved vascular function upon pioglitazone treatment in type 2 diabetes is not associated with changes in mononuclear NF-kappaB binding activity.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2007;39(9):665-71.
2007: von Eynatten M; Lepper P M; Liu D; Lang K; Baumann M; Nawroth P P; Bierhaus A; Dugi K A; Heemann U; Allolio B; Humpert P M
Retinol-binding protein 4 is associated with components of the metabolic syndrome, but not with insulin resistance, in men with type 2 diabetes or coronary artery disease.
Diabetologia 2007;50(9):1930-7.
2007: Rudofsky Gottfried; Schlotterer Andreas; Nawroth Peter P; Bierhaus Angelika; Hamann Andreas
Comment on: Lin et al. (2007) SUMO4 M55V variant is associated with diabetic nephropathy in type 2 diabetes: Diabetes 56: 1177-1180.
Diabetes 2007;56(8):e11; author reply e12-3.
2007: Humpert P M; Kopf S; Djuric Z; Laine K; Korosoglou G; Rudofsky G; Hamann A; Morcos M; von Eynatten M; Nawroth P P; Bierhaus A
Levels of three distinct p75 neurotrophin receptor forms found in human plasma are altered in type 2 diabetic patients.
Diabetologia 2007;50(7):1517-22.
2007: Morcos M; Fohr B; Tafel J; Pfisterer F; Hamann A; Humpert P; Bode H; Schwenger V; Zeier M; Becker C; Kasperk C; Schilling T; Hammes H P; Bierhaus A; Nawroth P P
Long-term treatment of central Cushing's syndrome with rosiglitazone.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2007;115(5):292-7.
2007: Tian Jane; Avalos Ana Maria; Mao Su-Yau; Chen Bo; Senthil Kannaki; Wu Herren; Parroche Peggy; Drabic Stacey; Golenbock Douglas; Sirois Cherilyn; Hua Jing; An Ling Ling; Audoly Laurent; La Rosa Greg; Bierhaus Angelika; Naworth Peter; Marshak-Rothstein Ann; Crow Mary K; Fitzgerald Katherine A; Latz Eicke; Kiener Peter A; Coyle Anthony J
Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE.
Nature immunology 2007;8(5):487-96.
2007: Rudofsky G; Schrödter A; Voron'ko O E; Schlotterer A; Humpert P M; Tafel J; Nawroth P P; Bierhaus A; Hamann A
Promoter polymorphisms of UCP1, UCP2, and UCP3 are not associated with diabetic microvascular complications in type 2 diabetes.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2007;39(4):306-9.
2007: Orlova Valeria V; Choi Eun Young; Xie Changping; Chavakis Emmanouil; Bierhaus Angelika; Ihanus Eveliina; Ballantyne Christie M; Gahmberg Carl G; Bianchi Marco E; Nawroth Peter P; Chavakis Triantafyllos
A novel pathway of HMGB1-mediated inflammatory cell recruitment that requires Mac-1-integrin.
The EMBO journal 2007;26(4):1129-39.
2007: Haslbeck Karl Matthias; Neundörfer Bernhard; Schlötzer-Schrehardtt Ursula; Bierhaus Angelika; Schleicher Erwin; Pauli Elisabeth; Haslbeck Manfred; Hecht Martin; Nawroth Peter; Heuss Dieter
Activation of the RAGE pathway: a general mechanism in the pathogenesis of polyneuropathies?
Neurological research 2007;29(1):103-10.
2007: Enk Ronny; Ehehalt Robert; Graham Jane E; Bierhaus Angelika; Remppis Andrew; Greten Henry Johannes
Differential effect of Rhizoma coptidis and its main alkaloid compound berberine on TNF-alpha induced NFkappaB translocation in human keratinocytes.
Journal of ethnopharmacology 2007;109(1):170-5.
2007: Humpert Per M; Djuric Zdenka; Kopf Stefan; Rudofsky Gottfried; Morcos Michael; Nawroth Peter P; Bierhaus Angelika
Soluble RAGE but not endogenous secretory RAGE is associated with albuminuria in patients with type 2 diabetes.
Cardiovascular diabetology 2007;6():9.
2006: Korosoglou Grigorios; Humpert Per M; Halbgewachs Eva; Bekeredjian Raffi; Filusch Arthur; Buss Sebastian J; Morcos Michael; Bierhaus Angelika; Katus Hugo A; Nawroth Peter P; Kuecherer Helmut
Evidence of left ventricular contractile asynchrony by echocardiographic phase imaging in patients with type 2 diabetes mellitus and without clinically evident heart disease.
The American journal of cardiology 2006;98(11):1525-30.
2006: Bierhaus Angelika; Stern David M; Nawroth Peter P
RAGE in inflammation: a new therapeutic target?
Current opinion in investigational drugs (London, England : 2000) 2006;7(11):985-91.
2006: Andrassy Martin; Igwe John; Autschbach Frank; Volz Christian; Remppis Andrew; Neurath Markus F; Schleicher Erwin; Humpert Per M; Wendt Thoralf; Liliensiek Birgit; Morcos Michael; Schiekofer Stephan; Thiele Kirsten; Chen Jiang; Kientsch-Engel Rose; Schmidt Ann-Marie; Stremmel Wolfgang; Stern David M; Katus Hugo A; Nawroth Peter P; Bierhaus Angelika
Posttranslationally modified proteins as mediators of sustained intestinal inflammation.
The American journal of pathology 2006;169(4):1223-37.
2006: Bierhaus Angelika; Humpert Per M; Nawroth Peter P
Linking stress to inflammation.
Anesthesiology clinics 2006;24(2):325-40.
2006: Plaschke Konstanze; Feindt Johanna; Djuric Zdenka; Heiland Sabine; Autschbach Frank; Lewicka Sabina; Martin Eike; Bardenheuer Hubert J; Nawroth Peter P; Bierhaus Angelika
Chronic corticosterone-induced deterioration in rat behaviour is not paralleled by changes in hippocampal NF-kappaB-activation.
Stress (Amsterdam, Netherlands) 2006;9(2):97-106.
2006: Humpert Per M; Battista Marco J; Lammert Alexander; Reismann Peter; Djuric Zdenka; Rudofsky Gottfried; Zorn Markus; Morcos Michael; Hammes Hans-Peter; Nawroth Peter P; Bierhaus Angelika
Association of stromal cell-derived factor 1 genotype with diabetic foot syndrome and macrovascular disease in patients with type 2 diabetes.
Clinical chemistry 2006;52(6):1206-8.
2006: Humpert Per M; Kopf Stefan; Djuric Zdenka; Wendt Thoralf; Morcos Michael; Nawroth Peter P; Bierhaus Angelika
Plasma sRAGE is independently associated with urinary albumin excretion in type 2 diabetes.
Diabetes care 2006;29(5):1111-3.
2006: Lin J; Bierhaus A; Bugert P; Dietrich N; Feng Y; Vom Hagen F; Nawroth P; Brownlee M; Hammes H-P
Effect of R-(+)-alpha-lipoic acid on experimental diabetic retinopathy.
Diabetologia 2006;49(5):1089-96.
2006: Schiekofer S; Franke S; Andrassy M; Chen J; Rudofsky G; Schneider J G; von Eynatten M; Wendt T; Morcos M; Kientsch-Engel R; Stein G; Schleicher E; Nawroth P P; Bierhaus A
Postprandial mononuclear NF-kappaB activation is independent of the AGE-content of a single meal.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2006;114(4):160-7.
2006: Zhou Zheng; Immel David; Xi Cai-Xia; Bierhaus Angelika; Feng Xu; Mei Lin; Nawroth Peter; Stern David M; Xiong Wen-Cheng
Regulation of osteoclast function and bone mass by RAGE.
The Journal of experimental medicine 2006;203(4):1067-80.
2006: Lange-Sperandio B; Schimpgen K; Rodenbeck B; Chavakis T; Bierhaus A; Nawroth P; Thornhill B; Schaefer F; Chevalier R L
Distinct roles of Mac-1 and its counter-receptors in neonatal obstructive nephropathy.
Kidney international 2006;69(1):81-8.
2006: Rudofsky Gottfried; Schroedter Antonia; Schlotterer Andreas; Voron'ko Olga E; Schlimme Martin; Tafel Joerg; Isermann Berend H; Humpert Per M; Morcos Michael; Bierhaus Angelika; Nawroth Peter P; Hamann Andreas
Functional polymorphisms of UCP2 and UCP3 are associated with a reduced prevalence of diabetic neuropathy in patients with type 1 diabetes.
Diabetes care 2006;29(1):89-94.
2006: Schwenger Vedat; Morath Christian; Salava Alexander; Amann Kerstin; Seregin Yuri; Deppisch Reinhold; Ritz Eberhard; Bierhaus Angelika; Nawroth Peter P; Zeier Martin
Damage to the peritoneal membrane by glucose degradation products is mediated by the receptor for advanced glycation end-products.
Journal of the American Society of Nephrology : JASN 2006;17(1):199-207.
2006: Ehlermann Philipp; Eggers Kai; Bierhaus Angelika; Most Patrick; Weichenhan Dieter; Greten Johannes; Nawroth Peter P; Katus Hugo A; Remppis Andrew
Increased proinflammatory endothelial response to S100A8/A9 after preactivation through advanced glycation end products.
Cardiovascular diabetology 2006;5():6.
2005: Bierhaus Angelika; Humpert Per M; Morcos Michael; Wendt Thoralf; Chavakis Triantafyllos; Arnold Bernd; Stern David M; Nawroth Peter P
Understanding RAGE, the receptor for advanced glycation end products.
Journal of molecular medicine (Berlin, Germany) 2005;83(11):876-86.
2005: Humpert P M; Bärtsch U; Konrade I; Hammes H-P; Morcos M; Kasper M; Bierhaus A; Nawroth P P
Locally applied mononuclear bone marrow cells restore angiogenesis and promote wound healing in a type 2 diabetic patient.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2005;113(9):538-40.
2005: Haslbeck K M; Friess U; Schleicher E D; Bierhaus A; Nawroth P P; Kirchner A; Pauli E; Neundörfer B; Heuss D
The RAGE pathway in inflammatory myopathies and limb girdle muscular dystrophy.
Acta neuropathologica 2005;110(3):247-54.
2005: Chen Jiang; Kasper Michael; Heck Tobias; Nakagawa Katsumi; Humpert Per M; Bai Ling; Wu Gang; Zhang Youming; Luther Thomas; Andrassy Martin; Schiekofer Stephan; Hamann Andreas; Morcos Michael; Chen Baoshen; Stern David M; Nawroth Peter P; Bierhaus Angelika
Tissue factor as a link between wounding and tissue repair.
Diabetes 2005;54(7):2143-54.
2005: Rudofsky G; Schlimme M; Schlotterer A; von Eynatten M; Reismann P; Tafel J; Grafe I; Morcos M; Nawroth P; Bierhaus A; Hamann A
No association of the 94T/G polymorphism in the adiponectin gene with diabetic complications.
Diabetes, obesity & metabolism 2005;7(4):455-9.
2005: Bierhaus Angelika; Humpert Per M; Stern David M; Arnold Bernd; Nawroth Peter P
Advanced glycation end product receptor-mediated cellular dysfunction.
Annals of the New York Academy of Sciences 2005;1043():676-80.
2005: Weiss Claus; Bierhaus Angelika; Nawroth Peter P; Bärtsch Peter
Effects of supplementation with alpha-lipoic acid on exercise-induced activation of coagulation.
Metabolism: clinical and experimental 2005;54(6):815-20.
2005: Haslbeck K-M; Schleicher E; Bierhaus A; Nawroth P; Haslbeck M; Neundörfer B; Heuss D
The AGE/RAGE/NF-(kappa)B pathway may contribute to the pathogenesis of polyneuropathy in impaired glucose tolerance (IGT).
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2005;113(5):288-91.
2005: Humpert Per M; Neuwirth Renate; Battista Marco J; Voronko Olga; von Eynatten Maximilian; Konrade Ilze; Rudofsky Gottfried; Wendt Thoralf; Hamann Andreas; Morcos Michael; Nawroth Peter P; Bierhaus Angelika
SDF-1 genotype influences insulin-dependent mobilization of adult progenitor cells in type 2 diabetes.
Diabetes care 2005;28(4):934-6.
2005: von Eynatten Maximilian; Schneider Jochen G; Hadziselimovic Senad; Hamann Andreas; Bierhaus Angelika; Nawroth Peter P; Dugi Klaus A
Adipocytokines as a novel target for the anti-inflammatory effect of atorvastatin in patients with type 2 diabetes.
Diabetes care 2005;28(3):754-5.
2005: Nawroth Peter; Bierhaus Angelika; Marrero Mario; Yamamoto Hiroshi; Stern David M
Atherosclerosis and restenosis: is there a role for RAGE?
Current diabetes reports 2005;5(1):11-6.
2005: Chavakis Triantafyllos; Athanasopoulos Athanasios; Rhee Joong-Sup; Orlova Valeria; Schmidt-Wöll Thomas; Bierhaus Angelika; May Andreas E; Celik Ilhan; Nawroth Peter P; Preissner Klaus T
Angiostatin is a novel anti-inflammatory factor by inhibiting leukocyte recruitment.
Blood 2005;105(3):1036-43.
2004: Bierhaus Angelika; Haslbeck Karl-Matthias; Humpert Per M; Liliensiek Birgit; Dehmer Thomas; Morcos Michael; Sayed Ahmed A R; Andrassy Martin; Schiekofer Stephan; Schneider Jochen G; Schulz Jörg B; Heuss Dieter; Neundörfer Bernhard; Dierl Stefan; Huber Jochen; Tritschler Hans; Schmidt Ann-Marie; Schwaninger Markus; Haering Hans-Ulrich; Schleicher Erwin; Kasper Michael; Stern David M; Arnold Bernd; Nawroth Peter P
Loss of pain perception in diabetes is dependent on a receptor of the immunoglobulin superfamily.
The Journal of clinical investigation 2004;114(12):1741-51.
2004: von Eynatten Maximilian; Schneider Jochen G; Humpert Per M; Rudofsky Gottfried; Schmidt Nikolaus; Barosch Patrizia; Hamann Andreas; Morcos Michael; Kreuzer Joerg; Bierhaus Angelika; Nawroth Peter P; Dugi Klaus A
Decreased plasma lipoprotein lipase in hypoadiponectinemia: an association independent of systemic inflammation and insulin resistance.
Diabetes care 2004;27(12):2925-9.
2004: Chavakis Triantafyllos; Bierhaus Angelika; Nawroth Peter P
RAGE (receptor for advanced glycation end products): a central player in the inflammatory response.
Microbes and infection / Institut Pasteur 2004;6(13):1219-25.
2004: Rudofsky G; Reismann P; Schiekofer S; Petrov D; Eynatten M von; Humpert P M; Isermann B; Müller-Hoff C; Thai T-P; Lichtenstein S; Bärtsch U; Hamann A; Nawroth P; Bierhaus A
Reduction of postprandial hyperglycemia in patients with type 2 diabetes reduces NF-kappaB activation in PBMCs.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2004;36(9):630-8.
2004: Bierhaus Angelika; Nawroth Peter P
Antiangiogenic properties of low molecular weight heparin - does tissue factor provide the answer?
Thrombosis and haemostasis 2004;92(3):438-9.
2004: Isermann Berend; Bierhaus Angelika; Humpert Per M; Rudofsky Gottfried; Chavakis Triantafyllos; Ritzel Robert; Wendt Thoralf; Morcos Michael; Kasperk Christian; Hamann Andreas; Nawroth Peter P
[AGE-RAGE: a hypothesis or a mechanism?]
Herz 2004;29(5):504-9.
2004: Luft Thomas; Maraskovsky Eugene; Schnurr Max; Knebel Katja; Kirsch Michael; Görner Martin; Skoda Radek; Ho Anthony D; Nawroth Peter; Bierhaus Angelika
Tuning the volume of the immune response: strength and persistence of stimulation determine migration and cytokine secretion of dendritic cells.
Blood 2004;104(4):1066-74.
2004: Reismann Peter; Lichy Christoph; Rudofsky Gottfried; Humpert Per M; Genius Just; Si Tuan-Dong; Dörfer Christof; Grau Armin J; Hamann Andreas; Hacke Werner; Nawroth Peter P; Bierhaus Angelika
Lack of association between polymorphisms of the toll-like receptor 4 gene and cerebral ischemia.
Journal of neurology 2004;251(7):853-8.
2004: Liliensiek Birgit; Weigand Markus A; Bierhaus Angelika; Nicklas Werner; Kasper Michael; Hofer Stefan; Plachky Jens; Gröne Herman-Josef; Kurschus Florian C; Schmidt Ann Marie; Yan Shi Du; Martin Eike; Schleicher Erwin; Stern David M; Hämmerling G G ünterJ; Nawroth Peter P; Arnold Bernd
Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response.
The Journal of clinical investigation 2004;113(11):1641-50.
2004: Haslbeck Karl-Matthias; Bierhaus Angelika; Erwin Schliecher; Kirchner Annette; Nawroth Peter; Schlötzer Ursula; Neundörfer Bernhard; Heuss Dieter
Receptor for advanced glycation endproduct (RAGE)-mediated nuclear factor-kappaB activation in vasculitic neuropathy.
Muscle & nerve 2004;29(6):853-60.
2004: Rudofsky G; Isermann B; Schilling T; Schiekofer S; Andrassy M; Schneider J G; Morcos M; Humpert P M; Sayed A A R; Witte S; Renn W; Pfohl M; Hamann A; Nosikov V; Schleicher E; Häring H-U; Rudofsky G; Ritz E; Nawroth P P; Bierhaus A
A 63bp deletion in the promoter of rage correlates with a decreased risk for nephropathy in patients with type 2 diabetes.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2004;112(3):135-41.
2004: Johst U; Khorchidi S; Bantleon R; Kehlbach R; Wiskirchen J; Rodegerdts E; Bierhaus A; Nawroth P P; Duda S H
[Liposome-mediated transfection of thrombomodulin in vascular smooth muscle cells--a gene therapy concept to inhibit recurrent stenosis]
RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin 2004;176(3):398-403.
2004: Rudofsky Gottfried; Reismann Peter; Witte Steffen; Humpert Per M; Isermann Berend; Chavakis Triantafyllos; Tafel Jörg; Nosikov Valery V; Hamann Andreas; Nawroth Peter; Bierhaus Angelika
Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with a reduced prevalence of diabetic neuropathy in patients with type 2 diabetes.
Diabetes care 2004;27(1):179-83.
2003: Liegibel Ute M; Sommer Ulrike; Boercsoek Irma; Hilscher Ulrike; Bierhaus Angelika; Schweikert Hans Udo; Nawroth Peter; Kasperk Christian
Androgen receptor isoforms AR-A and AR-B display functional differences in cultured human bone cells and genital skin fibroblasts.
Steroids 2003;68(14):1179-87.
2003: Bierhaus Angelika; Humpert Per M; Rudofsky Gottfried; Wendt Thoralf; Morcos Michael; Hamann Andreas; Nawroth Peter P
New treatments for diabetic neuropathy: pathogenetically oriented treatment.
Current diabetes reports 2003;3(6):452-8.
2003: Chavakis Triantafyllos; Bierhaus Angelika; Al-Fakhri Nadia; Schneider Darius; Witte Steffen; Linn Thomas; Nagashima Mariko; Morser John; Arnold Bernd; Preissner Klaus T; Nawroth Peter P
The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: a novel pathway for inflammatory cell recruitment.
The Journal of experimental medicine 2003;198(10):1507-15.
2003: Nawroth Peter; Pirzer Rainer; Fohr Berthold; Schilling Tobias; Ziegler Reinhard; Bierhaus Angelika; Kasperk Christian
[Osteoporosis and cardiovascular disease--two sides of the same coin?]
Medizinische Klinik (Munich, Germany : 1983) 2003;98(8):437-46.
2003: Schiekofer S; Rudofsky G; Andrassy M; Schneider J; Chen J; Isermann B; Kanitz M; Elsenhans S; Heinle H; Balletshofer B; Häring H-U; Schleicher E; Nawroth P P; Bierhaus A
Glimepiride reduces mononuclear activation of the redox-sensitive transcription factor nuclear factor-kappa B.
Diabetes, obesity & metabolism 2003;5(4):251-61.
2003: Rhee Joong-Sup; Santoso Sentot; Herrmann Mathias; Bierhaus Angelika; Kanse Sandip M; May Andreas E; Nawroth Peter P; Colman Robert W; Preissner Klaus T; Chavakis Triantafyllos
New aspects of integrin-mediated leukocyte adhesion in inflammation: regulation by haemostatic factors and bacterial products.
Current molecular medicine 2003;3(4):387-92.
2003: Weigert Cora; Brodbeck Katrin; Bierhaus Angelika; Häring Hans U; Schleicher Erwin D
c-Fos-driven transcriptional activation of transforming growth factor beta-1: inhibition of high glucose-induced promoter activity by thiazolidinediones.
Biochemical and biophysical research communications 2003;304(2):301-7.
2003: Wendt Thoralf; Tanji Nozomu; Guo Jiancheng; Hudson Barry I; Bierhaus Angelika; Ramasamy Ravichandran; Arnold Bernd; Nawroth Peter P; Yan Shi Fang; D'Agati Vivette; Schmidt Ann Marie
Glucose, glycation, and RAGE: implications for amplification of cellular dysfunction in diabetic nephropathy.
Journal of the American Society of Nephrology : JASN 2003;14(5):1383-95.
2003: Wendt Thoralf M; Tanji Nozomu; Guo Jiancheng; Kislinger Thomas R; Qu Wu; Lu Yan; Bucciarelli Loredana G; Rong Ling Ling; Moser Bernhard; Markowitz Glen S; Stein Gunther; Bierhaus Angelika; Liliensiek Birgit; Arnold Bernd; Nawroth Peter P; Stern David M; D'Agati Vivette D; Schmidt Ann Marie
RAGE drives the development of glomerulosclerosis and implicates podocyte activation in the pathogenesis of diabetic nephropathy.
The American journal of pathology 2003;162(4):1123-37.
2003: Schiekofer Stephan; Andrassy Martin; Chen Jiang; Rudofsky Gottfried; Schneider Jochen; Wendt Thoralf; Stefan Norbert; Humpert Per; Fritsche Andreas; Stumvoll Michael; Schleicher Erwin; Häring Hans-Ulrich; Nawroth Peter P; Bierhaus Angelika
Acute hyperglycemia causes intracellular formation of CML and activation of ras, p42/44 MAPK, and nuclear factor kappaB in PBMCs.
Diabetes 2003;52(3):621-33.
2003: Hammes Hans-Peter; Du Xueliang; Edelstein Diane; Taguchi Tetsuya; Matsumura Takeshi; Ju Qida; Lin Jihong; Bierhaus Angelika; Nawroth Peter; Hannak Dieter; Neumaier Michael; Bergfeld Regine; Giardino Ida; Brownlee Michael
Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy.
Nature medicine 2003;9(3):294-9.
2003: Bierhaus Angelika; Wolf Jutta; Andrassy Martin; Rohleder Nicolas; Humpert Per M; Petrov Dimitri; Ferstl Roman; von Eynatten Maximilian; Wendt Thoralf; Rudofsky Gottfried; Joswig Martina; Morcos Michael; Schwaninger Markus; McEwen Bruce; Kirschbaum Clemens; Nawroth Peter P
A mechanism converting psychosocial stress into mononuclear cell activation.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):1920-5.
2003: Bierhaus Angelika; Nawroth Peter P
Modulation of the vascular endothelium during infection--the role of NF-kappa B activation.
Contributions to microbiology 2003;10():86-105.
2002: Morcos Michael; Sayed Ahmed A R; Bierhaus Angelika; Yard Benito; Waldherr Rüdiger; Merz Wolfgang; Kloeting Ingrid; Schleicher Erwin; Mentz Stefani; Abd el Baki Randa F; Tritschler Hans; Kasper Michael; Schwenger Vedat; Hamann Andreas; Dugi Klaus A; Schmidt Anne-Marie; Stern David; Ziegler Reinhard; Haering Hans U; Andrassy Martin; van der Woude Fokko; Nawroth Peter P
Activation of tubular epithelial cells in diabetic nephropathy.
Diabetes 2002;51(12):3532-44.
2002: Andrassy M; Bierhaus A; Hong M; Sis J; Schiekofer S; Humper P M; Chen J; Haap M; Renn W; Schleicher E; Häring H U; Andrassy K; Nawroth P P
Erythropoietin-mediated decrease of the redox-sensitive transcription factor NF-kappaB is inversely correlated with the hemoglobin level.
Clinical nephrology 2002;58(3):179-89.
2002: Weiss Claus; Bierhaus Angelika; Kinscherf Ralf; Hack Volker; Luther Thomas; Nawroth Peter Paul; Bärtsch Peter
Tissue factor-dependent pathway is not involved in exercise-induced formation of thrombin and fibrin.
Journal of applied physiology (Bethesda, Md. : 1985) 2002;92(1):211-8.
2001: Bierhaus A; Schiekofer S; Schwaninger M; Andrassy M; Humpert P M; Chen J; Hong M; Luther T; Henle T; Klöting I; Morcos M; Hofmann M; Tritschler H; Weigle B; Kasper M; Smith M; Perry G; Schmidt A M; Stern D M; Häring H U; Schleicher E; Nawroth P P
Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB.
Diabetes 2001;50(12):2792-808.
2001: Chen J; Bierhaus A; Schiekofer S; Andrassy M; Chen B; Stern D M; Nawroth P P
Tissue factor--a receptor involved in the control of cellular properties, including angiogenesis.
Thrombosis and haemostasis 2001;86(1):334-45.
2001: Schleicher E D; Bierhaus A; Häring H U; Nawroth P P; Lehmann R
Chemistry and pathobiology of advanced glycation end products.
Contributions to nephrology 2001;(131):1-9.
2000: Quehenberger P; Bierhaus A; Fasching P; Muellner C; Klevesath M; Hong M; Stier G; Sattler M; Schleicher E; Speiser W; Nawroth P P
Endothelin 1 transcription is controlled by nuclear factor-kappaB in AGE-stimulated cultured endothelial cells.
Diabetes 2000;49(9):1561-70.
2000: Bierhaus A; Chen J; Liliensiek B; Nawroth P P
LPS and cytokine-activated endothelium.
Seminars in thrombosis and hemostasis 2000;26(5):571-87.
2000: Schiekofer S; Balletshofer B; Andrassy M; Bierhaus A; Nawroth P P
Endothelial dysfunction in diabetes mellitus.
Seminars in thrombosis and hemostasis 2000;26(5):503-11.
1999: Thiele K; Bierhaus A; Autschbach F; Hofmann M; Stremmel W; Thiele H; Ziegler R; Nawroth P P
Cell specific effects of glucocorticoid treatment on the NF-kappaBp65/IkappaBalpha system in patients with Crohn's disease.
Gut 1999;45(5):693-704.
1999: Hofmann M A; Schiekofer S; Isermann B; Kanitz M; Henkels M; Joswig M; Treusch A; Morcos M; Weiss T; Borcea V; Abdel Khalek A K; Amiral J; Tritschler H; Ritz E; Wahl P; Ziegler R; Bierhaus A; Nawroth P P
Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kappaB.
Diabetologia 1999;42(2):222-32.
1999: Nawroth P P; Bierhaus A; Vogel G E; Hofmann M A; Zumbach M; Wahl P; Ziegler R
[Non-enzymatic glycation and oxidative stress in chronic illnesses and diabetes mellitus]
Medizinische Klinik (Munich, Germany : 1983) 1999;94(1):29-38.
1998: Hofmann M A; Schiekofer S; Kanitz M; Klevesath M S; Joswig M; Lee V; Morcos M; Tritschler H; Ziegler R; Wahl P; Bierhaus A; Nawroth P P
Insufficient glycemic control increases nuclear factor-kappa B binding activity in peripheral blood mononuclear cells isolated from patients with type 1 diabetes.
Diabetes care 1998;21(8):1310-6.
1998: Hofmann M A; Kohl B; Zumbach M S; Borcea V; Bierhaus A; Henkels M; Amiral J; Schmidt A M; Fiehn W; Ziegler R; Wahl P; Nawroth P P
Hyperhomocyst(e)inemia and endothelial dysfunction in IDDM.
Diabetes care 1998;21(5):841-8.
1998: Bierhaus A; Hofmann M A; Ziegler R; Nawroth P P
AGEs and their interaction with AGE-receptors in vascular disease and diabetes mellitus. I. The AGE concept.
Cardiovascular research 1998;37(3):586-600.
1997: Hölschermann H; Kohl O; Maus U; Dürfeld F; Bierhaus A; Nawroth P P; Lohmeyer J; Tillmanns H; Haberbosch W
Cyclosporin A inhibits monocyte tissue factor activation in cardiac transplant recipients.
Circulation 1997;96(12):4232-8.
1997: Hofmann M A; Kohl B; Zumbach M S; Borcea V; Bierhaus A; Henkels M; Amiral J; Fiehn W; Ziegler R; Wahl P; Nawroth P P
Hyperhomocyst(e)inemia and endothelial dysfunction in IDDM.
Diabetes care 1997;20(12):1880-6.
1997: Bierhaus A; Illmer T; Kasper M; Luther T; Quehenberger P; Tritschler H; Wahl P; Ziegler R; Müller M; Nawroth P P
Advanced glycation end product (AGE)-mediated induction of tissue factor in cultured endothelial cells is dependent on RAGE.
Circulation 1997;96(7):2262-71.
1997: Bierhaus A; Chevion S; Chevion M; Hofmann M; Quehenberger P; Illmer T; Luther T; Berentshtein E; Tritschler H; Müller M; Wahl P; Ziegler R; Nawroth P P
Advanced glycation end product-induced activation of NF-kappaB is suppressed by alpha-lipoic acid in cultured endothelial cells.
Diabetes 1997;46(9):1481-90.
1997: Böhrer H; Qiu F; Zimmermann T; Zhang Y; Jllmer T; Männel D; Böttiger B W; Stern D M; Waldherr R; Saeger H D; Ziegler R; Bierhaus A; Martin E; Nawroth P P
Role of NFkappaB in the mortality of sepsis.
The Journal of clinical investigation 1997;100(5):972-85.
1997: Bierhaus A; Zhang Y; Quehenberger P; Luther T; Haase M; Müller M; Mackman N; Ziegler R; Nawroth P P
The dietary pigment curcumin reduces endothelial tissue factor gene expression by inhibiting binding of AP-1 to the DNA and activation of NF-kappa B.
Thrombosis and haemostasis 1997;77(4):772-82.
1996: Luther T; Flössel C; Mackman N; Bierhaus A; Kasper M; Albrecht S; Sage E H; Iruela-Arispe L; Grossmann H; Ströhlein A; Zhang Y; Nawroth P P; Carmeliet P; Loskutoff D J; Müller M
Tissue factor expression during human and mouse development.
The American journal of pathology 1996;149(1):101-13.
1996: Zhang Y; Deng Y; Wendt T; Liliensiek B; Bierhaus A; Greten J; He W; Chen B; Hach-Wunderle V; Waldherr R; Ziegler R; Männel D; Stern D M; Nawroth P P
Intravenous somatic gene transfer with antisense tissue factor restores blood flow by reducing tumor necrosis factor-induced tissue factor expression and fibrin deposition in mouse meth-A sarcoma.
The Journal of clinical investigation 1996;97(10):2213-24.
1996: Kasper M; Bierhaus A; Whyte A; Binns R M; Schuh D; Müller M
Expression of CD44 isoforms during bleomycin-or radiation-induced pulmonary fibrosis in rats and mini-pigs.
Histochemistry and cell biology 1996;105(3):221-30.
1996: Boehme M W; Deng Y; Raeth U; Bierhaus A; Ziegler R; Stremmel W; Nawroth P P
Release of thrombomodulin from endothelial cells by concerted action of TNF-alpha and neutrophils: in vivo and in vitro studies.
Immunology 1996;87(1):134-40.
1996: Bierhaus A; Ritz E; Nawroth P P
Expression of receptors for advanced glycation end-products in occlusive vascular and renal disease.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1996;11 Suppl 5():87-90.
1995: Bierhaus A; Zhang Y; Deng Y; Mackman N; Quehenberger P; Haase M; Luther T; Müller M; Böhrer H; Greten J
Mechanism of the tumor necrosis factor alpha-mediated induction of endothelial tissue factor.
The Journal of biological chemistry 1995;270(44):26419-32.
1995: Wendt T; Zhang Y M; Bierhaus A; Kriegsmann J; Deng Y; Waldherr R; Teske T; Luther T; Fünfstück R; Nawroth P P
Tissue factor expression in an animal model of hydronephrosis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1995;10(10):1820-8.
1995: Ritthaler U; Deng Y; Zhang Y; Greten J; Abel M; Sido B; Allenberg J; Otto G; Roth H; Bierhaus A
Expression of receptors for advanced glycation end products in peripheral occlusive vascular disease.
The American journal of pathology 1995;146(3):688-94.
1995: Bierhaus A; Hemmer C J; Mackman N; Kutob R; Ziegler R; Dietrich M; Nawroth P P
Antiparasitic treatment of patients with P. falciparum malaria reduces the ability of patient serum to induce tissue factor by decreasing NF-kappa B activation.
Thrombosis and haemostasis 1995;73(1):39-48.
1994: Hemmer C J; Bierhaus A; von Riedesel J; Gabat S; Liliensiek B; Pitronik P; Lin J; Grauer A; Amiral J; Ziegler R
Elevated thrombomodulin plasma levels as a result of endothelial involvement in plasmodium falciparum malaria.
Thrombosis and haemostasis 1994;72(3):457-64.
1993: Nawroth P P; Waldherr R; Zhang Y M; Lin J; Bierhaus A; Lu J; Riedesel J; Zu E J; Kasperk C; Ziegler R
Mechanism of endothelial cell activation.
Transplantation proceedings 1993;25(2):2052-3.
1991: Hemmer C J; Kern P; Holst F G; Radtke K P; Egbring R; Bierhaus A; Nawroth P P; Dietrich M
Activation of the host response in human Plasmodium falciparum malaria: relation of parasitemia to tumor necrosis factor/cachectin, thrombin-antithrombin III, and protein C levels.
The American journal of medicine 1991;91(1):37-44.

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