FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Bart Roep

Research Profile

Disorders

Anatomy

Chemicals & Drugs

Physiology

Co-author Network

Publications

TOP 3
M von Herrath; M Peakman; Bart O Roep
Progress in immune-based therapies for type 1 diabetes.
Loes M Kuijk; Niels V Rekers; Bart O Roep; Sven C Bruijns; Tanja D de Gruijl; Erik Hooijberg; Yvette van Kooyk; Marleen I Verstege; Wendy W J Unger
Notch controls generation and function of human effector CD8+ T cells.
Gonnie M Alkemade; Xavier Clemente-Casares; Bart O Roep; Sue Tsai; Jinguo Wang; James R Wright; Bao-You Xu; Zhenguo Yu; Pere Santamaria
Local autoantigen expression as essential gatekeeper of memory T-cell recruitment to islet grafts in diabetic hosts.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Bart Roep (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: M von Herrath; M Peakman; Bart O Roep
Progress in immune-based therapies for type 1 diabetes.
Clinical and experimental immunology 2013;172(2):186-202.
2013: Loes M Kuijk; Niels V Rekers; Bart O Roep; Sven C Bruijns; Tanja D de Gruijl; Erik Hooijberg; Yvette van Kooyk; Marleen I Verstege; Wendy W J Unger
Notch controls generation and function of human effector CD8+ T cells.
Blood 2013;121(14):2638-46.
2013: Gonnie M Alkemade; Xavier Clemente-Casares; Bart O Roep; Sue Tsai; Jinguo Wang; James R Wright; Bao-You Xu; Zhenguo Yu; Pere Santamaria
Local autoantigen expression as essential gatekeeper of memory T-cell recruitment to islet grafts in diabetic hosts.
Diabetes 2013;62(3):905-11.
2013: Fleur S Kleijwegt; Sandra Laban; Tatjana Nikolic; Diahann T S L Jansen; Antoinette M Joosten; Josefine Teeler; Bart O Roep
Tolerogenic dendritic cells impede priming of naïve CD8⁺ T cells and deplete memory CD8⁺ T cells.
European journal of immunology 2013;43(1):85-92.
2013: V M de Jong; S P Persengiev; Bart O Roep; Arno R van der Slik; Arnaud Zaldumbide; Bobby P C Koeleman
Post-transcriptional control of candidate risk genes for type 1 diabetes by rare genetic variants.
Genes and immunity 2013;14(1):58-61.
2012: J R F Abreu; J W Drijfhout; Y E Fillié; K L M C Franken; S Martina; A A Verrijn Stuart; Bart O Roep
CD8 T cell autoreactivity to preproinsulin epitopes with very low human leucocyte antigen class I binding affinity.
Clinical and experimental immunology 2012;170(1):57-65.
2012: Volkert A L Huurman; Bart Keymeulen; Daniel G Pipeleers; Dave L Roelen; F H J Claas; Gaby Duinkerken; Pieter Gillard; Frans K Gorus; Robert Hilbrands; E P M W van der Meer-Prins; C R van der Torren; Bart O Roep
Immune responses against islet allografts during tapering of immunosuppression--a pilot study in 5 subjects.
Clinical and experimental immunology 2012;169(2):190-8.
2012: Bart O Roep; Mark Peakman
Antigen targets of type 1 diabetes autoimmunity.
Cold Spring Harbor perspectives in medicine 2012;2(4):a007781.
2012: Menno van Lummel; Peter A van Veelen; Arnaud Zaldumbide; Antonis K Moustakas; George K Papadopoulos; Bart O Roep; Arnoud de Ru; Jan W Drijfhout; George M C Janssen; Frits Koning
Type 1 diabetes-associated HLA-DQ8 transdimer accommodates a unique peptide repertoire.
The Journal of biological chemistry 2012;287(12):9514-24.
2012: Gabriela Bomfim Ferreira; Daniel Aaen Hansen; Fleur S Kleijwegt; Kasper Lage; Tatjana Nikolic; Lut Overbergh; Bart O Roep; Etienne Waelkens; Christopher T Workman; Chantal Mathieu
Differential protein pathways in 1,25-dihydroxyvitamin d(3) and dexamethasone modulated tolerogenic human dendritic cells.
Journal of proteome research 2012;11(2):941-71.
2012: Ken T Coppieters; Francesco Dotta; Thomas W H Kay; Bart O Roep; Natalie Amirian; Mark A Atkinson; Peter D Campbell; Matthias G von Herrath
Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients.
The Journal of experimental medicine 2012;209(1):51-60.
2012: Karsten Buschard; Jan-Eric Månsson; Bart O Roep; Tatjana Nikolic
Self-glycolipids modulate dendritic cells changing the cytokine profiles of committed autoreactive T cells.
PloS one 2012;7(12):e52639.
2012: Wendy W J Unger; Arno R van der Slik; Dave V Serreze; Leonard D Shultz; Joana R F Abreu; Sacha Mulder-van der Kracht; Jan Wouter Drijfhout; Dale L Greiner; Marieke Griffioen; Michel Kester; Sandra Laban; Todd Pearson; Bart O Roep
Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/scid/IL2RG null mice.
PloS one 2012;7(11):e49213.
2012: Arnaud Zaldumbide; Shoshan Knaän-Shanzer; Bart O Roep; Emmanuel J H J Wiertz; Françoise Carlotti; Steve J Cramer; Manuel A F V Gonçalves; Rob Hoeben
Adenoviral vectors stimulate glucagon transcription in human mesenchymal stem cells expressing pancreatic transcription factors.
PloS one 2012;7(10):e48093.
2011: Bart O Roep; Mark Peakman
Diabetogenic T lymphocytes in human Type 1 diabetes.
Current opinion in immunology 2011;23(6):746-53.
2011: Aaron W Michels; Maki Nakayama; David A Ostrov; Bart O Roep; Li Zhang; Mark A Atkinson; Masanori Fuse; Peter A Gottlieb; Kristen McDaniel; George S Eisenbarth
Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(11):5921-30.
2011: Yvonne Kooy-Winkelaar; M Luisa Mearin; Antonis K Moustakas; Chris J Mulder; George K Papadopoulos; Bart O Roep; Joachim Schweizer; Jeroen Van Bergen; Menno van Lummel; Jan Wouter Drijfhout; Frits Koning
Gluten-specific T cells cross-react between HLA-DQ8 and the HLA-DQ2α/DQ8β transdimer.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(10):5123-9.
2011: Gonnie M Alkemade; Robert Hilbrands; Bart Keymeulen; Chantal Mathieu; Daniel Pipeleers; Evy Vandemeulebroucke; Herman Waldmann; Bart O Roep
Preservation of recall immunity in anti-CD3-treated recent onset type 1 diabetes patients.
Diabetes/metabolism research and reviews 2011;27(8):925-7.
2011: wendy unger; Jurjen H L Velthuis; Schumacher Ton; Joana R F Abreu; Arnold H Bakker; Jan Wouter Drijfhout; Gaby Duinkerken; Kees L M C Franken; Robert Hilbrands; Michel Kester; Bart Keymeulen; Sandra Laban; Arend Mulder; Ferry Ossendorp; Mark Peakman; Edwin Quinten; Sine Reker-Hadrup; Bart O Roep
Discovery of low-affinity preproinsulin epitopes and detection of autoreactive CD8 T-cells using combinatorial MHC multimers.
Journal of autoimmunity 2011;37(3):151-9.
2011: Peter Eerligh; Bobby P C Koeleman; Antonis K Moustakas; George K Papadopoulos; George P Bondinas; Gaby Duinkerken; M van Lummel; Arnaud Zaldumbide; Bart O Roep
Functional consequences of HLA-DQ8 homozygosity versus heterozygosity for islet autoimmunity in type 1 diabetes.
Genes and immunity 2011;12(6):415-27.
2011: P Eerligh; Bobby P C Koeleman; B A Lie; Bart O Roep; E Thorsby
No extreme genetic risk for type 1 diabetes among DR3/4-DQ8 siblings sharing both extended HLA haplotypes with their diabetic proband.
Tissue antigens 2011;77(4):338-40.
2011: Maarten Titulaer; Paul Maddison; Jacob K Sont; Paul W Wirtz; David Hilton-Jones; Rinse Klooster; Nick Willcox; Marko Potman; Peter A E Sillevis Smitt; J B M Kuks; Bart O Roep; Angela Vincent; Silvère M van der Maarel; J Gert van Dijk; Bethan Lang; Jan J Verschuuren
Clinical Dutch-English Lambert-Eaton Myasthenic syndrome (LEMS) tumor association prediction score accurately predicts small-cell lung cancer in the LEMS.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2011;29(7):902-8.
2011: Karsten Buschard; Axel Kornerup Hansen; Karen Jensen; Dicky J Lindenbergh-Kortleve; Lilian F de Ruiter; Thomas C Krohn; Majbritt R Hufeldt; Finn K Vogensen; Bent Aasted; Thomas Osterbye; Bart O Roep; Colin de Haar; Edward E S Nieuwenhuis
Alcohol facilitates CD1d loading, subsequent activation of NKT cells, and reduces the incidence of diabetes in NOD mice.
PloS one 2011;6(4):e17931.
2011: Ken T Coppieters; Bart O Roep; Matthias G von Herrath
Beta cells under attack: toward a better understanding of type 1 diabetes immunopathology.
Seminars in immunopathology 2011;33(1):1-7.
2010: Fleur S Kleijwegt; Sandra Laban; Gaby Duinkerken; Antoinette M Joosten; Arnaud Zaldumbide; Tatjana Nikolic; Bart O Roep
Critical role for TNF in the induction of human antigen-specific regulatory T cells by tolerogenic dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(3):1412-8.
2010: Jurjen H Velthuis; wendy unger; Joana R F Abreu; Gaby Duinkerken; Kees Franken; Mark Peakman; Arnold H Bakker; Sine Reker-Hadrup; Bart Keymeulen; Jan Wouter Drijfhout; Ton N Schumacher; Bart O Roep
Simultaneous detection of circulating autoreactive CD8+ T-cells specific for different islet cell-associated epitopes using combinatorial MHC multimers.
Diabetes 2010;59(7):1721-30.
2010: Stephan Persengiev; Bobby P C Koeleman; Kate Downes; Gustavo Valdigem; Arno R van der Slik; Peter Eerligh; Alienke Monsuur; G Jan Bruining; Cisca Wijmenga; John A Todd; Bart O Roep; Behrooz Alizadeh
Association analysis of myosin IXB and type 1 diabetes.
Human immunology 2010;71(6):598-601.
2010: Timothy I M Tree; Jennifer Lawson; Hannah Edwards; Ania Skowera; Sefina Arif; Bart O Roep; Mark Peakman
Naturally arising human CD4 T-cells that recognize islet autoantigens and secrete interleukin-10 regulate proinflammatory T-cell responses via linked suppression.
Diabetes 2010;59(6):1451-60.
2010: Diane van der Woude; Benedicte Lie; Emeli Lundström; Alejandro Balsa; Anouk L Feitsma; Jeanine J Houwing-Duistermaat; Willem Verduijn; Gry B N Nordang; Lars Alfredsson; Lars Klareskog; Dora Pascual-Salcedo; Miguel A Gonzalez-Gay; Miguel A Lopez-Nevot; Fernando Valero; Bart O Roep; Tom W J Huizinga; Tore K Kvien; Javier Martín; Leonid Padyukov; René R P De Vries; René E M Toes
Protection against anti-citrullinated protein antibody-positive rheumatoid arthritis is predominantly associated with HLA-DRB1*1301: a meta-analysis of HLA-DRB1 associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis in four European populations.
Arthritis and rheumatism 2010;62(5):1236-45.
2010: A V Kharagjitsingh; M A J de Ridder; Bart O Roep; Bobby P C Koeleman; G Jan Bruining; Henk J Veeze
Revisiting infant growth prior to childhood onset type 1 diabetes.
Clinical endocrinology 2010;72(5):620-4.
2010: Fina A S Kurreeman; George N Goulielmos; Behrooz Alizadeh; Blanca Rueda; Jeanine J Houwing-Duistermaat; Elena Sanchez; Marianna Bevova; Timothy R Radstake; Madelon C Vonk; Emmanouil Galanakis; Norberto Ortego; Willem Verduyn; Maria I Zervou; Bart O Roep; Barbara Dema; Laura Espino; Elena Urcelay; Dimitrios T Boumpas; Leonard H van den Berg; Cisca Wijmenga; Bobby P C Koeleman; Tom W J Huizinga; René E M Toes; Javier Martin
The TRAF1-C5 region on chromosome 9q33 is associated with multiple autoimmune diseases.
Annals of the rheumatic diseases 2010;69(4):696-9.
2010: Bart O Roep; F S Kleijwegt; Astrid G S van Halteren; V Bonato; Ugo Boggi; F Vendrame; P Marchetti; Francesco Dotta
Islet inflammation and CXCL10 in recent-onset type 1 diabetes.
Clinical and experimental immunology 2010;159(3):338-43.
2010: Bart O Roep; Mark Peakman
Surrogate end points in the design of immunotherapy trials: emerging lessons from type 1 diabetes.
Nature reviews. Immunology 2010;10(2):145-52.
2009: Simona Cernea; Itamar Raz; Kevan C Herold; Boaz Hirshberg; Bart O Roep; Desmond A Schatz; G Alexander Fleming; Paolo Pozzilli; Randie Little; Nanette C Schloot; richard leslie; Jay S Skyler; Jerry P Palmer
Challenges in developing endpoints for type 1 diabetes intervention studies.
Diabetes/metabolism research and reviews 2009;25(8):694-704.
2009: wendy unger; Sandra Laban; Fleur S Kleijwegt; Arno R van der Slik; Bart O Roep
Induction of Treg by monocyte-derived DC modulated by vitamin D3 or dexamethasone: differential role for PD-L1.
European journal of immunology 2009;39(11):3147-59.
2009: David M Harlan; Norma S Kenyon; Olle Korsgren; Bart O Roep
Current advances and travails in islet transplantation.
Diabetes 2009;58(10):2175-84.
2009: Robert Hilbrands; Volkert A L Huurman; Pieter Gillard; Jurjen H L Velthuis; Marc De Waele; Chantal Mathieu; Leonard Kaufman; Miriam Pipeleers-Marichal; Zhidong Ling; Babak Movahedi; Daniel Jacobs-Tulleneers-Thevissen; Diethard Monbaliu; Dirk Ysebaert; Frans K Gorus; Bart O Roep; Daniel G Pipeleers; Bart Keymeulen
Differences in baseline lymphocyte counts and autoreactivity are associated with differences in outcome of islet cell transplantation in type 1 diabetic patients.
Diabetes 2009;58(10):2267-76.
2009: Pieter Gillard; Volkert Huurman; Bart Van der Auwera; Brigitte Decallonne; Kris Poppe; Bart O Roep; Frans Gorus; Chantal Mathieu; Daniel Pipeleers; Bart Keymeulen
Graves hyperthyroidism after stopping immunosuppressive therapy in type 1 diabetic Islet cell recipients with pretransplant TPO autoantibodies.
Diabetes care 2009;32(10):1817-9.
2009: Sonia Chamorro; Juan Jesus Garcia Vallejo; wendy unger; Rosette J Fernandes; Sven C M Bruijns; Sandra Laban; Bart O Roep; Bert A 't Hart; Yvette van Kooyk
TLR triggering on tolerogenic dendritic cells results in TLR2 up-regulation and a reduced proinflammatory immune program.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(5):2984-94.
2009: Dave L Roelen; V A L Huurman; R Hilbrands; P Gillard; Gaby Duinkerken; P W M van der Meer-Prins; M F J Versteeg-van der Voort Maarschalk; C Mathieu; B Keymeulen; Daniel G Pipeleers; Bart O Roep; F H J Claas
Relevance of cytotoxic alloreactivity under different immunosuppressive regimens in clinical islet cell transplantation.
Clinical and experimental immunology 2009;156(1):141-8.
2009: J H Velthuis; wendy unger; Arno R van der Slik; Gaby Duinkerken; M Engelse; A F Schaapherder; J Ringers; Cees van Kooten; E J de Koning; Bart O Roep
Accumulation of autoreactive effector T cells and allo-specific regulatory T cells in the pancreas allograft of a type 1 diabetic recipient.
Diabetologia 2009;52(3):494-503.
2009: Volkert A L Huurman; J H L Velthuis; Robert Hilbrands; T I M Tree; P Gillard; P M W van der Meer-Prins; Gaby Duinkerken; G G M Pinkse; Bart Keymeulen; Dave L Roelen; F H J Claas; Daniel G Pipeleers; Bart O Roep
Allograft-specific cytokine profiles associate with clinical outcome after islet cell transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2009;9(2):382-8.
2008: Anna Skowera; Richard J Ellis; Ruben Varela-Calviño; Sefina Arif; Guo Huang; Cassie Van-Krinks; Anna Zaremba; Chloe Rackham; Jennifer S Allen; tim tree; Min Zhao; Colin M Dayan; Andrew K Sewell; wendy unger; Wendy Unger; Jan W Drijfhout; Ferry Ossendorp; Bart O Roep; Mark Peakman
CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope.
The Journal of clinical investigation 2008;118(10):3390-402.
2008: C Pfleger; A Kaas; Lars Hansen; Behrooz Alizadeh; Philip Hougaard; R Holl; H Kolb; Bart O Roep; Henrik B Mortensen; Nanette C Schloot
Relation of circulating concentrations of chemokine receptor CCR5 ligands to C-peptide, proinsulin and HbA1c and disease progression in type 1 diabetes.
Clinical immunology (Orlando, Fla.) 2008;128(1):57-65.
2008: Volkert A L Huurman; P E van der Meide; Gaby Duinkerken; Sabine Willemen; Irun R Cohen; D Elias; Bart O Roep
Immunological efficacy of heat shock protein 60 peptide DiaPep277 therapy in clinical type I diabetes.
Clinical and experimental immunology 2008;152(3):488-97.
2008: Bart O Roep
Islet autoreactive CD8 T-cells in type 1 diabetes: licensed to kill?
Diabetes 2008;57(5):1156.
2008: Srinath Sanda; Bart O Roep; Matthias von Herrath
Islet antigen specific IL-10+ immune responses but not CD4+CD25+FoxP3+ cells at diagnosis predict glycemic control in type 1 diabetes.
Clinical immunology (Orlando, Fla.) 2008;127(2):138-43.
2008: Christian Pfleger; Henrik B Mortensen; Lars Hansen; Christian Herder; Bart O Roep; Hillary Hoey; Henk-Jan Aanstoot; Mirjana Kocova; Nanette C Schloot
Association of IL-1ra and adiponectin with C-peptide and remission in patients with type 1 diabetes.
Diabetes 2008;57(4):929-37.
2008: A V Kharagjitsingh; K Prinsen; H H P J Lemkes; R R P de Vries; Bart O Roep; K Buschard
Reduced frequency of blood group Lewis a-b- in female Type 1 diabetes patients.
Diabetic medicine : a journal of the British Diabetic Association 2008;25(2):236-8.
2008: Bart O Roep
Immune markers of disease and therapeutic intervention in type 1 diabetes.
Novartis Foundation symposium 2008;292():159-71; discussion 171-3, 202-3.
2008: Volkert A L Huurman; Robert Hilbrands; Gabriëlle G M Pinkse; Pieter Gillard; Gaby Duinkerken; Pieter van de Linde; Petronella M W van der Meer-Prins; Minke F J Versteeg-van der Voort Maarschalk; Koen Verbeeck; Behrooz Alizadeh; Chantal Mathieu; Frans K Gorus; Dave L Roelen; Frans H J Claas; Bart Keymeulen; Daniel G Pipeleers; Bart O Roep
Cellular islet autoimmunity associates with clinical outcome of islet cell transplantation.
PloS one 2008;3(6):e2435.
2007: Bart O Roep
Diabetes: missing links.
Nature 2007;450(7171):799-800.
2007: Alexandra Zhernakova; Behrooz Alizadeh; Marianna R Bevova; Miek A van Leeuwen; Marieke Coenen; Barbara Franke; Lude Franke; Marcel D Posthumus; David A van Heel; Gerrit van der Steege; Timothy Radstake; Pilar Barrera; Bart O Roep; Bobby P C Koeleman; Cisca Wijmenga
Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases.
American journal of human genetics 2007;81(6):1284-8.
2007: Volkert A L Huurman; wendy unger; Bobby P C Koeleman; M K Oaks; A K Chandraker; Onno T Terpstra; Bart O Roep
Differential inhibition of autoreactive memory- and alloreactive naive T cell responses by soluble cytotoxic T lymphocyte antigen 4 (sCTLA4), CTLA4Ig and LEA29Y.
Clinical and experimental immunology 2007;150(3):487-93.
2007: Behrooz Alizadeh; Gustavo Valdigem; Marieke Coenen; Alexandra Zhernakova; Barbara Franke; Alienke J Monsuur; P L C M van Riel; Pilar Barrera; Timothy Radstake; Bart O Roep; Cisca Wijmenga; Bobby P C Koeleman
Association analysis of functional variants of the FcgRIIa and FcgRIIIa genes with type 1 diabetes, celiac disease and rheumatoid arthritis.
Human molecular genetics 2007;16(21):2552-9.
2007: Pieter van de Linde; P J M Vd Boog; O M H Tysma; John Elliott; Dave L Roelen; Frans H J Claas; Johan W de Fijter; Bart O Roep
Selective unresponsiveness to beta cell autoantigens after induction immunosuppression in pancreas transplantation with anti-interleukin-2 receptor antibody versus anti-thymocyte globulin.
Clinical and experimental immunology 2007;149(1):56-62.
2007: Nanette C Schloot; Pejman Hanifi-Moghaddam; N Aabenhus-Andersen; Behrooz Alizadeh; M T Saha; Mikael Knip; D Devendra; T Wilkin; E Bonifacio; Bart O Roep; Hubert Kolb; T Mandrup-Poulsen
Association of immune mediators at diagnosis of Type 1 diabetes with later clinical remission.
Diabetic medicine : a journal of the British Diabetic Association 2007;24(5):512-20.
2007: Volkert A L Huurman; Katelijn Decochez; Chantal Mathieu; Irun R Cohen; Bart O Roep
Therapy with the hsp60 peptide DiaPep277 in C-peptide positive type 1 diabetes patients.
Diabetes/metabolism research and reviews 2007;23(4):269-75.
2007: Arno R van der Slik; Behrooz Alizadeh; Bobby P C Koeleman; Bart O Roep; Marius J Giphart
Modelling KIR-HLA genotype disparities in type 1 diabetes.
Tissue antigens 2007;69 Suppl 1():101-5.
2007: Arno R van der Slik; I van den Eng; Peter Eerligh; Ilias Doxiadis; Bobby P C Koeleman; Bart O Roep; Marius J Giphart
Sequence variation within the major histocompatibility complex subregion centromeric of HLA class II in type 1 diabetes.
Tissue antigens 2007;69(4):348-53.
2007: wendy unger; Gabrielle G M Pinkse; S Mulder-van der Kracht; Arno R van der Slik; Michel Kester; Ferry Ossendorp; Jan Wouter Drijfhout; D V Serreze; Bart O Roep
Human clonal CD8 autoreactivity to an IGRP islet epitope shared between mice and men.
Annals of the New York Academy of Sciences 2007;1103():192-5.
2007: Bart O Roep
Are insights gained from NOD mice sufficient to guide clinical translation? Another inconvenient truth.
Annals of the New York Academy of Sciences 2007;1103():1-10.
2007: Behrooz Alizadeh; Peter Eerligh; Arno R van der Slik; Arun Shastry; Alexandra Zhernakova; Gustavo Valdigem; Jan G Bruining; Carani B Sanjeevi; Cisca Wijmenga; Bart O Roep; Bobby P C Koeleman
MICA marks additional risk factors for Type 1 diabetes on extended HLA haplotypes: an association and meta-analysis.
Molecular immunology 2007;44(11):2806-12.
2007: Francesco Dotta; Stefano Censini; Astrid G S van Halteren; Lorella Marselli; Matilde Masini; Simona Dionisi; Franco Mosca; Ugo Boggi; Andrea Onetti Muda; John Elliott; Antonello Covacci; Rino Rappuoli; Bart O Roep; Stefano Del Prato; Piero Marchetti
Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(12):5115-20.
2007: Evelyne van Etten; Lieve Verlinden; Annapaula Giulietti; Elizabeth Ramos Lopez; Dumitru D Branisteanu; Gabriela B Ferreira; Lut Overbergh; Annemieke Verstuyf; Roger Bouillon; Bart O Roep; Klaus Badenhoop; Chantal Mathieu
The vitamin D receptor gene FokI polymorphism: functional impact on the immune system.
European journal of immunology 2007;37(2):395-405.
2006: Gabrielle G M Pinkse; Christian Boitard; tim tree; Mark Peakman; Bart O Roep
HLA class I epitope discovery in type 1 diabetes: independent and reproducible identification of proinsulin epitopes of CD8 T cells--report of the IDS T Cell Workshop Committee.
Annals of the New York Academy of Sciences 2006;1079():19-23.
2006: tim tree; Bart O Roep; Mark Peakman
A mini meta-analysis of studies on CD4+CD25+ T cells in human type 1 diabetes: report of the Immunology of Diabetes Society T Cell Workshop.
Annals of the New York Academy of Sciences 2006;1079():9-18.
2006: Alexandra Zhernakova; Behrooz Alizadeh; Peter Eerligh; Pejman Hanifi-Moghaddam; Nanette C Schloot; Begoña Diosdado; Cisca Wijmenga; Bart O Roep; Bobby P C Koeleman
Genetic variants of RANTES are associated with serum RANTES level and protection for type 1 diabetes.
Genes and immunity 2006;7(7):544-9.
2006: Behrooz Alizadeh; Pejman Hanifi-Moghaddam; Peter Eerligh; Arno R van der Slik; H Kolb; A V Kharagjitsingh; A M Pereira Arias; M Ronkainen; Mikael Knip; R Bonfanti; E Bonifacio; D Devendra; T Wilkin; Marius J Giphart; Bobby P C Koeleman; Runa Louise Nolsoe; T Mandrup Poulsen; Nanette C Schloot; Bart O Roep
Association of interferon-gamma and interleukin 10 genotypes and serum levels with partial clinical remission in type 1 diabetes.
Clinical and experimental immunology 2006;145(3):480-4.
2006: Ivana Durinovic-Belló; Silke Rosinger; Jennifer A Olson; Mauro Congia; Regina C Ahmad; Mathias Rickert; Johannes Hampl; Hubert Kalbacher; Jan Wouter Drijfhout; Elizabeth D Mellins; Sascha Al Dahouk; Thomas Kamradt; Markus J Maeurer; Carol Nhan; Bart O Roep; Bernhard O Boehm; Constantin Polychronakos; Gerald Nepom; Wolfram Karges; Hugh McDevitt; Grete Sønderstrup
DRB1*0401-restricted human T cell clone specific for the major proinsulin73-90 epitope expresses a down-regulatory T helper 2 phenotype.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(31):11683-8.
2006: Erik H Niks; J B M Kuks; Bart O Roep; Geert W Haasnoot; Willem Verduijn; B E P B Ballieux; Marc H De Baets; Angela Vincent; Jan J Verschuuren
Strong association of MuSK antibody-positive myasthenia gravis and HLA-DR14-DQ5.
Neurology 2006;66(11):1772-4.
2006: Pieter van de Linde; O M H Tysma; J P Medema; G Hale; H Waldmann; Dave L Roelen; Bart O Roep
Mechanisms of antibody immunotherapy on clonal islet reactive T cells.
Human immunology 2006;67(4-5):264-73.
2006: Lee H Bouwman; Bart O Roep; Anja Roos
Mannose-binding lectin: clinical implications for infection, transplantation, and autoimmunity.
Human immunology 2006;67(4-5):247-56.
2006: Volkert A L Huurman; Jayant S Kalpoe; Pieter van de Linde; Norbert Vaessen; Jan Ringers; Aloys C M Kroes; Bart O Roep; Johan W de Fijter
Choice of antibody immunotherapy influences cytomegalovirus viremia in simultaneous pancreas-kidney transplant recipients.
Diabetes care 2006;29(4):842-7.
2006: Pejman Hanifi-Moghaddam; S Kappler; Jochen Seissler; Sylvia Müller-Scholze; Stephan Martin; Bart O Roep; Klaus Strassburger; Hubert Kolb; Nanette C Schloot
Altered chemokine levels in individuals at risk of Type 1 diabetes mellitus.
Diabetic medicine : a journal of the British Diabetic Association 2006;23(2):156-63.
2005: Gabrielle G M Pinkse; Odette H M Tysma; Cees A M Bergen; Michel Kester; Ferry Ossendorp; Peter van Veelen; Bart Keymeulen; Daniel Pipeleers; Jan Wouter Drijfhout; Bart O Roep
Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetes.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(51):18425-30.
2005: Gisela Orozco; Peter Eerligh; Elena Sánchez; Sasha Zhernakova; Bart O Roep; Miguel A González-Gay; Miguel A López-Nevot; José L Callejas; Carmen Hidalgo; Dora Pascual-Salcedo; Alejandro Balsa; María Francisca González-Escribano; Bobby P C Koeleman; Javier Martín
Analysis of a functional BTNL2 polymorphism in type 1 diabetes, rheumatoid arthritis, and systemic lupus erythematosus.
Human immunology 2005;66(12):1235-41.
2005: Pieter van de Linde; Bart O Roep
T-cell assays to determine disease activity and clinical efficacy of immune therapy in type 1 diabetes.
American journal of therapeutics 2005;12(6):573-9.
2005: Lee H Bouwman; Peter Eerligh; Onno T Terpstra; Mohamed R Daha; Peter de Knijff; B E P B Ballieux; G Jan Bruining; Arno R van der Slik; Anja Roos; Bart O Roep
Elevated levels of mannose-binding lectin at clinical manifestation of type 1 diabetes in juveniles.
Diabetes 2005;54(10):3002-6.
2005: Alexandra Zhernakova; Peter Eerligh; Pilar Barrera; Joanna Wesoly; Joanna Z Weseloy; Tom W J Huizinga; Bart O Roep; Cisca Wijmenga; Bobby P C Koeleman
CTLA4 is differentially associated with autoimmune diseases in the Dutch population.
Human genetics 2005;118(1):58-66.
2005: Alexandra Zhernakova; Peter Eerligh; Cisca Wijmenga; Pilar Barrera; Bart O Roep; Bobby P C Koeleman
Differential association of the PTPN22 coding variant with autoimmune diseases in a Dutch population.
Genes and immunity 2005;6(6):459-61.
2005: Lee H Bouwman; Anja Roos; Onno T Terpstra; Peter de Knijff; Bart van Hoek; Hein Verspaget; Stefan P Berger; Mohamed R Daha; Marijke Frölich; Arno R van der Slik; Ilias Doxiadis; Bart O Roep; Alexander F M Schaapherder
Mannose binding lectin gene polymorphisms confer a major risk for severe infections after liver transplantation.
Gastroenterology 2005;129(2):408-14.
2005: Corine A van Kampen; Pieter van de Linde; Gaby Duinkerken; Jolien J van Schip; Dave L Roelen; Bart Keymeulen; Daniel G Pipeleers; Frans H J Claas; Bart O Roep
Alloreactivity against repeated HLA mismatches of sequential islet grafts transplanted in non-uremic type 1 diabetes patients.
Transplantation 2005;80(1):118-26.
2005: Lee H Bouwman; Zhidong Ling; Gaby Duinkerken; Daniel G Pipeleers; Bart O Roep
HLA incompatibility and immunogenicity of human pancreatic islet preparations cocultured with blood cells of healthy donors.
Human immunology 2005;66(5):494-500.
2005: Paul W Wirtz; Nick Willcox; Arno R van der Slik; Bethan Lang; Paul Maddison; Bobby P C Koeleman; Marius J Giphart; Axel R Wintzen; Bart O Roep; Jan J Verschuuren
HLA and smoking in prediction and prognosis of small cell lung cancer in autoimmune Lambert-Eaton myasthenic syndrome.
Journal of neuroimmunology 2005;159(1-2):230-7.
2005: Astrid G S van Halteren; Marrie J Kardol; Arend Mulder; Bart O Roep
Homing of human autoreactive T cells into pancreatic tissue of NOD-scid mice.
Diabetologia 2005;48(1):75-82.
2005: Shelley Lindley; Colin M Dayan; Amanda Bishop; Bart O Roep; Mark Peakman; tim tree
Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes.
Diabetes 2005;54(1):92-9.
2004: tim tree; Bart O Roep; Mark Peakman
Enhancing the sensitivity of assays to detect T cell reactivity: the effect of cell separation and cryopreservation media.
Annals of the New York Academy of Sciences 2004;1037():26-32.
2004: Masao Nagata; Reiko Kotani; Hiroaki Moriyama; Koichi Yokono; Bart O Roep; Mark Peakman
Detection of autoreactive T cells in type 1 diabetes using coded autoantigens and an immunoglobulin-free cytokine ELISPOT assay: report from the fourth immunology of diabetes society T cell workshop.
Annals of the New York Academy of Sciences 2004;1037():10-5.
2004: Bart O Roep; Mark Atkinson; Matthias von Herrath
Satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes.
Nature reviews. Immunology 2004;4(12):989-97.
2004: Astrid G S van Halteren; O M H Tysma; Evelyne van Etten; Chantal Mathieu; Bart O Roep
1alpha,25-dihydroxyvitamin D3 or analogue treated dendritic cells modulate human autoreactive T cells via the selective induction of apoptosis.
Journal of autoimmunity 2004;23(3):233-9.
2004: Bart O Roep; M Atkinson
Animal models have little to teach us about type 1 diabetes: 1. In support of this proposal.
Diabetologia 2004;47(10):1650-6.
2004: Ramachandra G Naik; Cora Beckers; Rino Wentwoord; Arlette Frenken; Gaby Duinkerken; Barbara Brooks-Worrell; Nanette C Schloot; Jerry P Palmer; Bart O Roep
Precursor frequencies of T-cells reactive to insulin in recent onset type 1 diabetes mellitus.
Journal of autoimmunity 2004;23(1):55-61.
2004: Bobby P C Koeleman; Benedicte Lie; DAG UNDLIEN; Frank Dudbridge; E Thorsby; René R P De Vries; Francesco Cucca; Bart O Roep; Marius J Giphart; J A Todd
Genotype effects and epistasis in type 1 diabetes and HLA-DQ trans dimer associations with disease.
Genes and immunity 2004;5(5):381-8.
2004: tim tree; Gaby Duinkerken; Sabine Willemen; René R P De Vries; Bart O Roep
HLA-DQ-regulated T-cell responses to islet cell autoantigens insulin and GAD65.
Diabetes 2004;53(7):1692-9.
2004: Peter Eerligh; Bart O Roep; Marius J Giphart; Bobby P C Koeleman
Insulin-like growth factor 1 promoter polymorphism influences insulin gene variable number of tandem repeat-associated risk for juvenile onset type 1 diabetes.
Tissue antigens 2004;63(6):568-71.
2004: Ivana Durinovic-Belló; Michael Schlosser; M Riedl; Nicola Maisel; Silke Rosinger; Hubert Kalbacher; Martin Deeg; M Ziegler; J Elliott; Bart O Roep; Wolfram Karges; Bernhard O Boehm
Pro- and anti-inflammatory cytokine production by autoimmune T cells against preproinsulin in HLA-DRB1*04, DQ8 Type 1 diabetes.
Diabetologia 2004;47(3):439-50.
2004: Sefina Arif; tim tree; Thomas P Astill; Jennifer M Tremble; Amanda J Bishop; Colin M Dayan; Bart O Roep; Mark Peakman
Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health.
The Journal of clinical investigation 2004;113(3):451-63.
2004: Peter Eerligh; Bobby P C Koeleman; Frank Dudbridge; G Jan Bruining; Bart O Roep; Marius J Giphart
Functional genetic polymorphisms in cytokines and metabolic genes as additional genetic markers for susceptibility to develop type 1 diabetes.
Genes and immunity 2004;5(1):36-40.
2004: Leroy R Lard; Bart O Roep; René E M Toes; Tom W J Huizinga
Enhanced concentrations of interleukin 16 are associated with joint destruction in patients with rheumatoid arthritis.
The Journal of rheumatology 2004;31(1):35-9.
2003: Nanette C Schloot; Guido Meierhoff; Maria Karlsson Faresjö; Patrick Ott; Amy Putnam; Paul Lehmann; Peter Gottlieb; Bart O Roep; Mark Peakman; Timothy Tree
Comparison of cytokine ELISpot assay formats for the detection of islet antigen autoreactive T cells. Report of the third immunology of diabetes society T-cell workshop.
Journal of autoimmunity 2003;21(4):365-76.
2003: Arno R van der Slik; Bobby P C Koeleman; Willem Verduijn; G Jan Bruining; Bart O Roep; Marius J Giphart
KIR in type 1 diabetes: disparate distribution of activating and inhibitory natural killer cell receptors in patients versus HLA-matched control subjects.
Diabetes 2003;52(10):2639-42.
2003: Bart O Roep
Molecular mimicry in autoimmune neurological disease after viral infection.
Current medicinal chemistry 2003;10(19):1939-43.
2003: Wai-Kwan Lam-Tse; Manou R Batstra; Bobby P C Koeleman; Bart O Roep; Mu G J Bruining; Henk-Jan Aanstoot; Hemmo Drexhage
The association between autoimmune thyroiditis, autoimmune gastritis and type 1 diabetes.
Pediatric endocrinology reviews : PER 2003;1(1):22-37.
2003: Paul W Wirtz; Nick Willcox; Bart O Roep; Bethan Lang; Axel R Wintzen; John Newsom-Davis; Jan J Verschuuren
HLA-B8 in patients with the Lambert-Eaton myasthenic syndrome reduces likelihood of associated small cell lung carcinoma.
Annals of the New York Academy of Sciences 2003;998():200-1.
2003: M Pascual; Bobby P C Koeleman; Peter Eerligh; Bart O Roep; J Martin
Distribution of HERV-LTR elements in HLA-DQB1 alleles: comments on the article by Bieda et al.
Diabetologia 2003;46(6):869-70; author reply 870-1.
2003: Willem-Johan T van de Beek; Bart O Roep; Arno R van der Slik; Marius J Giphart; Bob J van Hilten
Susceptibility loci for complex regional pain syndrome.
Pain 2003;103(1-2):93-7.
2003: Bart O Roep
The role of T-cells in the pathogenesis of Type 1 diabetes: from cause to cure.
Diabetologia 2003;46(3):305-21.
2003: James E Greening; tim tree; Karolena T Kotowicz; Astrid G S van Halteren; Bart O Roep; Nigel J Klein; Mark Peakman
Processing and presentation of the islet autoantigen GAD by vascular endothelial cells promotes transmigration of autoreactive T-cells.
Diabetes 2003;52(3):717-25.
2002: Bart O Roep
Autoreactive T cells in endocrine/organ-specific autoimmunity: why has progress been so slow?
Springer seminars in immunopathology 2002;24(3):261-71.
2002: Bart O Roep
Type 1 diabetes: how to resist a fatal attraction.
The Netherlands journal of medicine 2002;60(7):296-7.
2002: P Martín Martorell; Bart O Roep; Jan W A Smit; P M Martorell
Autoimmunity in Addison's disease.
The Netherlands journal of medicine 2002;60(7):269-75.
2002: Astrid G S van Halteren; Evelyne van Etten; Esther C de Jong; Roger Bouillon; Bart O Roep; Chantal Mathieu
Redirection of human autoreactive T-cells Upon interaction with dendritic cells modulated by TX527, an analog of 1,25 dihydroxyvitamin D(3).
Diabetes 2002;51(7):2119-25.
2002: Bart O Roep; N K van den Engel; Astrid G S van Halteren; Gaby Duinkerken; S Martin
Modulation of autoimmunity to beta-cell antigens by proteases.
Diabetologia 2002;45(5):686-92.
2002: Bobby P C Koeleman; Gustavo Valdigem; Peter Eerligh; Marius J Giphart; Bart O Roep
Seasonality of birth in patients with type 1 diabetes.
Lancet 2002;359(9313):1246-7; author reply 1247-8.
2002: B V P C Koeleman; K N De Groot; Arno R van der Slik; Bart O Roep; Marius J Giphart
Association between D6S2223 and type I diabetes independent of HLA class II in Dutch families.
Diabetologia 2002;45(4):598-9.
2002: Bart O Roep; HS Hiemstra; Nanette C Schloot; René R P De Vries; A Chaudhuri; Peter Behan; Jan Wouter Drijfhout
Molecular mimicry in type 1 diabetes: immune cross-reactivity between islet autoantigen and human cytomegalovirus but not Coxsackie virus.
Annals of the New York Academy of Sciences 2002;958():163-5.
2002: Astrid G S van Halteren; Bart O Roep; Silvia Gregori; Anne Cooke; Willem van Eden; Georg Kraal; Marca H M Wauben
Cross-reactive mycobacterial and self hsp60 epitope recognition in I-A(g7) expressing NOD, NOD-asp and Biozzi AB/H mice.
Journal of autoimmunity 2002;18(2):139-47.
2002: Leroy R Lard; Bart O Roep; Cornelis A Verburgh; Aeilko H Zwinderman; Tom W J Huizinga
Elevated IL-16 levels in patients with systemic lupus erythematosus are associated with disease severity but not with genetic susceptibility to lupus.
Lupus 2002;11(3):181-5.
2001: Paul W Wirtz; Bart O Roep; G M Th Schreuder; Pieter A Van Doorn; B G M van Engelen; J B M Kuks; Albert Twijnstra; Marianne De Visser; LH Visser; J H J Wokke; Axel R Wintzen; Jan J Verschuuren
HLA class I and II in Lambert-Eaton myasthenic syndrome without associated tumor.
Human immunology 2001;62(8):809-13.
2001: Mark Peakman; tim tree; J Endl; PM van Endert; M A Atkinson; Bart O Roep
Characterization of preparations of GAD65, proinsulin, and the islet tyrosine phosphatase IA-2 for use in detection of autoreactive T-cells in type 1 diabetes: report of phase II of the Second International Immunology of Diabetes Society Workshop for Standardization of T-cell assays in type 1 diabetes.
Diabetes 2001;50(8):1749-54.
2001: Nanette C Schloot; Sabine Willemen; Gaby Duinkerken; Jan Wouter Drijfhout; René R P De Vries; Bart O Roep
Molecular mimicry in type 1 diabetes mellitus revisited: T-cell clones to GAD65 peptides with sequence homology to Coxsackie or proinsulin peptides do not crossreact with homologous counterpart.
Human immunology 2001;62(4):299-309.
2001: HS Hiemstra; Nanette C Schloot; Peter van Veelen; Sabine Willemen; Kees L M C Franken; Jon van Rood; René R P De Vries; A Chaudhuri; Peter Behan; Jan Wouter Drijfhout; Bart O Roep
Cytomegalovirus in autoimmunity: T cell crossreactivity to viral antigen and autoantigen glutamic acid decarboxylase.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(7):3988-91.
2001: RF Schipper; Bobby P C Koeleman; G Jan Bruining; G M Th Schreuder; Willem Verduijn; René R P De Vries; Bart O Roep
HLA class II associations with Type 1 diabetes mellitus: a multivariate approach.
Tissue antigens 2001;57(2):144-50.
2000: Einar Van Essen; Bart O Roep; L M 't Hart; JJ Jansen; J M W van den Ouweland; Herman H P J Lemkes; J Antonie Maassen
HLA-DQ polymorphism and degree of heteroplasmy of the A3243G mitochondrial DNA mutation in maternally inherited diabetes and deafness.
Diabetic medicine : a journal of the British Diabetic Association 2000;17(12):841-7.
2000: Astrid G S van Halteren; B Mosselman; Bart O Roep; Willem van Eden; A Cooke; Georg Kraal; Marca H M Wauben
T cell reactivity to heat shock protein 60 in diabetes-susceptible and genetically protected nonobese diabetic mice is associated with a protective cytokine profile.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(10):5544-51.
2000: Willem-Johan T van de Beek; Jacobus J van Hilten; Bart O Roep
HLA-DQ1 associated with reflex sympathetic dystrophy.
Neurology 2000;55(3):457-8.
2000: Jacobus J van Hilten; Willem-Johan T van de Beek; Bart O Roep
Multifocal or generalized tonic dystonia of complex regional pain syndrome: a distinct clinical entity associated with HLA-DR13.
Annals of neurology 2000;48(1):113-6.
2000: C J Hawkes; Nanette C Schloot; J Marks; Sabine Willemen; Jan Wouter Drijfhout; E K Mayer; Michael R Christie; Bart O Roep
T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes.
Diabetes 2000;49(3):356-66.
2000: HS Hiemstra; Jan Wouter Drijfhout; Bart O Roep
Antigen arrays in T cell immunology.
Current opinion in immunology 2000;12(1):80-4.
1999: I Stobbe; Gaby Duinkerken; Jon van Rood; A Lernmark; Bart Keymeulen; Daniel Pipeleers; René R P De Vries; F H Glass; Bart O Roep
Tolerance to kidney allograft transplanted into Type I diabetic patients persists after in vivo challenge with pancreatic islet allografts that express repeated mismatches.
Diabetologia 1999;42(11):1379-80.
1999: HS Hiemstra; Peter van Veelen; Annemieke Geluk; Nanette C Schloot; René R P De Vries; Tom H M Ottenhoff; Bart O Roep; Jan Wouter Drijfhout
Limitations of homology searching for identification of T-cell antigens with library derived mimicry epitopes.
Vaccine 1999;18(3-4):204-8.
1999: Bart O Roep; M A Atkinson; P M van Endert; P A Gottlieb; S B Wilson; J A Sachs
Autoreactive T cell responses in insulin-dependent (Type 1) diabetes mellitus. Report of the first international workshop for standardization of T cell assays.
Journal of autoimmunity 1999;13(2):267-82.
1999: HS Hiemstra; Peter van Veelen; Sabine Willemen; Willemien Benckhuijsen; Annemieke Geluk; René R P De Vries; Bart O Roep; Jan Wouter Drijfhout
Quantitative determination of TCR cross-reactivity using peptide libraries and protein databases.
European journal of immunology 1999;29(8):2385-91.
1999: Bart O Roep; Ruth G B Schipper; Willem Verduyn; G Jan Bruining; G M Th Schreuder; René R P De Vries
HLA-DRB1*0403 is associated with dominant protection against IDDM in the general Dutch population and subjects with high-risk DQA1*0301-DQB1*0302/DQA1*0501-DQB1*0201 genotype.
Tissue antigens 1999;54(1):88-90.
1999: Nanette C Schloot; M C Batstra; Gaby Duinkerken; René R P De Vries; T Dyrberg; A Chaudhuri; Peter Behan; Bart O Roep
GAD65-Reactive T cells in a non-diabetic stiff-man syndrome patient.
Journal of autoimmunity 1999;12(4):289-96.
1999: L D Peterson; M van der Keur; René R P De Vries; Bart O Roep
Autoreactive and immunoregulatory T-cell subsets in insulin-dependent diabetes mellitus.
Diabetologia 1999;42(4):443-9.
1999: Bart O Roep; I Stobbe; Gaby Duinkerken; Jon van Rood; A Lernmark; Bart Keymeulen; Daniel Pipeleers; Frans H J Claas; René R P De Vries
Auto- and alloimmune reactivity to human islet allografts transplanted into type 1 diabetic patients.
Diabetes 1999;48(3):484-90.
1998: HS Hiemstra; Peter van Veelen; Nanette C Schloot; Annemieke Geluk; Krista E van Meijgaarden; Sabine Willemen; Jack Leunissen; Willemien Benckhuijsen; R Amons; René R P De Vries; Bart O Roep; Tom H M Ottenhoff; Jan Wouter Drijfhout
Definition of natural T cell antigens with mimicry epitopes obtained from dedicated synthetic peptide libraries.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(8):4078-82.
1998: Annemieke Geluk; Krista E van Meijgaarden; Nanette C Schloot; Jan Wouter Drijfhout; Tom H M Ottenhoff; Bart O Roep
HLA-DR binding analysis of peptides from islet antigens in IDDM.
Diabetes 1998;47(10):1594-601.
1998: René R P De Vries; Bart O Roep
Clinical and preclinical immunology of type 1 diabetes.
The Netherlands journal of medicine 1998;53(3):127-9.
1998: Annemieke Geluk; Krista E van Meijgaarden; Bart O Roep; Tom H M Ottenhoff
Altered peptide ligands of islet autoantigen Imogen 38 inhibit antigen specific T cell reactivity in human type-1 diabetes.
Journal of autoimmunity 1998;11(4):353-61.
1998: Nanette C Schloot; Sabine Willemen; Gaby Duinkerken; René R P De Vries; Bart O Roep
Cloned T cells from a recent onset IDDM patient reactive with insulin B-chain.
Journal of autoimmunity 1998;11(2):169-75.
1998: Pejman Hanifi-Moghaddam; P de Knijf; Bart O Roep; Bart J R Van der Auwera; Albert M I H Naipal; Frans K Gorus; Frans Schuit; Marius J Giphart
Genetic structure of IDDM1: two separate regions in the major histocompatibility complex contribute to susceptibility or protection. Belgian Diabetes Registry.
Diabetes 1998;47(2):263-9.
1997: A A Kallan; Gaby Duinkerken; R de Jong; P van den Elsen; J C Hutton; S Martin; Bart O Roep; René R P De Vries
Th1-like cytokine production profile and individual specific alterations in TCRBV-gene usage of T cells from newly diagnosed type 1 diabetes patients after stimulation with beta-cell antigens.
Journal of autoimmunity 1997;10(6):589-98.
1997: HS Hiemstra; Gaby Duinkerken; Willemien Benckhuijsen; R Amons; René R P De Vries; Bart O Roep; Jan Wouter Drijfhout
The identification of CD4+ T cell epitopes with dedicated synthetic peptide libraries.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(19):10313-8.
1997: Nanette C Schloot; Bart O Roep
Islet antigen-specific T cell clones in autoimmune diabetes: from mice to men.
Diabetes/metabolism reviews 1997;13(3):127-38.
1997: PH Moghaddam; Aeilko H Zwinderman; P de Knijff; Bart O Roep; RF Schipper; Bart J R Van der Auwera; Albert M I H Naipal; Frans K Gorus; Frans Schuit; Marius J Giphart
TNFa microsatellite polymorphism modulates the risk of IDDM in Caucasians with the high-risk genotype HLA DQA1*0501-DQB1*0201/DQA1*0301-DQB1*0302. Belgian Diabetes Registry.
Diabetes 1997;46(9):1514-5.
1996: L D Petersen; Gaby Duinkerken; G Jan Bruining; R A van Lier; René R P De Vries; Bart O Roep
Increased numbers of in vivo activated T cells in patients with recent onset insulin-dependent diabetes mellitus.
Journal of autoimmunity 1996;9(6):731-7.
1996: Bart O Roep
T-cell responses to autoantigens in IDDM. The search for the Holy Grail.
Diabetes 1996;45(9):1147-56.
1996: Bart O Roep; Gaby Duinkerken; G M Th Schreuder; H Kolb; René R P De Vries; S Martin
HLA-associated inverse correlation between T cell and antibody responsiveness to islet autoantigen in recent-onset insulin-dependent diabetes mellitus.
European journal of immunology 1996;26(6):1285-9.
1996: P I Neophytou; Bart O Roep; S D Arden; E M Muir; Gaby Duinkerken; A Kallan; René R P De Vries; John C Hutton
T-cell epitope analysis using subtracted expression libraries (TEASEL): application to a 38-kDA autoantigen recognized by T cells from an insulin-dependent diabetic patient.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(5):2014-8.
1996: S D Arden; Bart O Roep; P I Neophytou; E F Usac; Gaby Duinkerken; René R P De Vries; John C Hutton
Imogen 38: a novel 38-kD islet mitochondrial autoantigen recognized by T cells from a newly diagnosed type 1 diabetic patient.
The Journal of clinical investigation 1996;97(2):551-61.
1996: A A Kallan; René R P De Vries; Bart O Roep
T-cell recognition of beta-cell autoantigens in insulin-dependent diabetes mellitus.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1996;104(1):3-11.
1995: A A Kallan; Bart O Roep; S D Arden; J C Hutton; René R P De Vries
Beta-cell reactive T-cell clones from type I diabetes patients are not beta cell specific and recognize multiple antigens.
Journal of autoimmunity 1995;8(6):887-99.
1995: Hubert Kolb; Victoria Kolb-Bachofen; Bart O Roep
Autoimmune versus inflammatory type I diabetes: a controversy?
Immunology today 1995;16(4):170-2.
1995: Bart O Roep; A A Kallan; Gaby Duinkerken; S D Arden; John C Hutton; G Jan Bruining; René R P De Vries
T-cell reactivity to beta-cell membrane antigens associated with beta-cell destruction in IDDM.
Diabetes 1995;44(3):278-83.
1995: Stephan Martin; J Kardorf; B Schulte; EF Lampeter; FA Gries; I Melchers; R Wagner; J Bertrams; Bart O Roep; A Pfützner
Autoantibodies to the islet antigen ICA69 occur in IDDM and in rheumatoid arthritis.
Diabetologia 1995;38(3):351-5.
1995: Stephan Martin; P Rieckmann; I Melchers; R Wagner; J Bertrams; Alexandre E Voskuyl; Bart O Roep; J Zielasek; E Heidenthal; I Weichselbraun
Circulating forms of ICAM-3 (cICAM-3). Elevated levels in autoimmune diseases and lack of association with cICAM-1.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(4):1951-5.
1994: Jemal Abdulkadir; Y Worku; Marius J Giphart; M Telahun; Bart O Roep; T H Ottenhoff; G M Schreuder
Susceptibility alleles at HLA-DRB1, -DQA1, and -DQB1 loci in Ethiopian childhood insulin-dependent diabetes mellitus.
Human immunology 1994;41(2):171-2.
1994: Bart O Roep; E Heidenthal; René R P De Vries; Hubert Kolb; Stephan Martin
Soluble forms of intercellular adhesion molecule-1 in insulin-dependent diabetes mellitus.
Lancet 1994;343(8913):1590-3.
1992: Bart O Roep; René R P De Vries
T-lymphocytes and the pathogenesis of type 1 (insulin-dependent) diabetes mellitus.
European journal of clinical investigation 1992;22(11):697-711.
1992: Bart O Roep; A A Kallan; René R P De Vries
Beta-cell antigen-specific lysis of macrophages by CD4 T-cell clones from newly diagnosed IDDM patient. A putative mechanism of T-cell-mediated autoimmune islet cell destruction.
Diabetes 1992;41(11):1380-4.
1992: Marius J Giphart; Bart O Roep; J Drabbels; Joe D'Amaro; G Jan Bruining; Jemal Abdulkadir; Willem Verduyn
Relative contribution of HLA-DQA and -DQB alleles to predisposition to insulin-dependent diabetes mellitus.
Human immunology 1992;34(2):142-6.
1991: Bart O Roep; A A Kallan; W L Hazenbos; G Jan Bruining; E M Bailyes; S D Arden; John C Hutton; René R P De Vries
T-cell reactivity to 38 kD insulin-secretory-granule protein in patients with recent-onset type 1 diabetes.
Lancet 1991;337(8755):1439-41.
1990: Bart O Roep; S D Arden; René R P De Vries; John C Hutton
T-cell clones from a type-1 diabetes patient respond to insulin secretory granule proteins.
Nature 1990;345(6276):632-4.
1989: E Van Vliet; Bart O Roep; L Meulenbroek; G Jan Bruining; René R P De Vries
Human T cell clones with specificity for insulinoma cell antigens.
European journal of immunology 1989;19(1):213-6.