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Paul Roepe

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Chemicals & Drugs

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Liva Harinantenaina; Jessica D Bowman; Peggy J Brodie; Martin W Callmander; Maria B Cassera; Alexander Gorka; Etienne Rakotobe; Richard Randrianaivo; Vincent E Rasamison; Paul D Roepe; Carla Slebodnick; David G I Kingston
Antiproliferative and antiplasmodial dimeric phloroglucinols from Mallotus oppositifolius from the Madagascar Dry Forest (1).
Alexander P Gorka; Lauren M Jacobs; Katherine B Nickley; John N Alumasa; Jonathan P Brower; Angel C De Dios; Katy S Sherlach; Paul D Roepe
Cytostatic versus cytocidal activities of chloroquine analogues and inhibition of hemozoin crystal growth.
Alexander P Gorka; Angel C De Dios; Katy S Sherlach; Paul D Roepe
Relative to quinine and quinidine, their 9-epimers exhibit decreased cytostatic activity and altered heme binding but similar cytocidal activity versus Plasmodium falciparum.

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All Publications

2013: Liva Harinantenaina; Jessica D Bowman; Peggy J Brodie; Martin W Callmander; Maria B Cassera; Alexander Gorka; Etienne Rakotobe; Richard Randrianaivo; Vincent E Rasamison; Paul D Roepe; Carla Slebodnick; David G I Kingston
Antiproliferative and antiplasmodial dimeric phloroglucinols from Mallotus oppositifolius from the Madagascar Dry Forest (1).
Journal of natural products 2013;76(3):388-93.
2013: Alexander P Gorka; Lauren M Jacobs; Katherine B Nickley; John N Alumasa; Jonathan P Brower; Angel C De Dios; Katy S Sherlach; Paul D Roepe
Cytostatic versus cytocidal activities of chloroquine analogues and inhibition of hemozoin crystal growth.
Antimicrobial agents and chemotherapy 2013;57(1):356-64.
2013: Alexander P Gorka; Angel C De Dios; Katy S Sherlach; Paul D Roepe
Relative to quinine and quinidine, their 9-epimers exhibit decreased cytostatic activity and altered heme binding but similar cytocidal activity versus Plasmodium falciparum.
Antimicrobial agents and chemotherapy 2013;57(1):365-74.
2012: Anthony P Sinai; Paul D Roepe
Autophagy in Apicomplexa: a life sustaining death mechanism?
Trends in parasitology 2012;28(9):358-64.
2012: Theresa Dinio; Alexander P Gorka; Andrew McGinniss; Paul D Roepe; Jeremy B Morgan
Investigating the activity of quinine analogues versus chloroquine resistant Plasmodium falciparum.
Bioorganic & medicinal chemistry 2012;20(10):3292-7.
2012: Debasish Ghosh; Paul D Roepe; Julia L Walton; Anthony P Sinai
Autophagy is a cell death mechanism in Toxoplasma gondii.
Cellular microbiology 2012;14(4):589-607.
2011: Katy S Sherlach; Alexa Dantzler; Alexander P Gorka; Paul D Roepe
Quantification of perchloroethylene residues in dry-cleaned fabrics.
Environmental toxicology and chemistry / SETAC 2011;30(11):2481-7.
2011: Ende Pan; Richard Randrianaivo; Paul D Roepe; Carla Slebodnick; John N Alumasa; Chris Birkinshaw; Peggy J Brodie; Alexander P Gorka; Liva Harinantenaina; David G I Kingston
Antiplasmodial and antiproliferative pseudoguaianolides of Athroisma proteiforme from the Madagascar Dry Forest.
Journal of natural products 2011;74(10):2174-80.
2011: Michelle F Paguio; Kelly L Bogle; Paul D Roepe
Plasmodium falciparum resistance to cytocidal versus cytostatic effects of chloroquine.
Molecular and biochemical parasitology 2011;178(1-2):1-6.
2011: John Alumasa; Alexander P Gorka; Leah B Casabianca; Erica Comstock; Angel C De Dios; Paul D Roepe
The hydroxyl functionality and a rigid proximal N are required for forming a novel non-covalent quinine-heme complex.
Journal of inorganic biochemistry 2011;105(3):467-75.
2011: Paul D Roepe
PfCRT-mediated drug transport in malarial parasites.
Biochemistry 2011;50(2):163-71.
2010: Jigar J Patel; Drew Thacker; John C Tan; Perri Pleeter; Lisa Checkley; Joseph M Gonzales; Bingbing Deng; Paul D Roepe; Roland A Cooper; Michael T Ferdig
Chloroquine susceptibility and reversibility in a Plasmodium falciparum genetic cross.
Molecular microbiology 2010;78(3):770-87.
2010: Perri Pleeter; Jacqueline K Lekostaj; Paul D Roepe
Purified Plasmodium falciparum multi-drug resistance protein (PfMDR 1) binds a high affinity chloroquine analogue.
Molecular and biochemical parasitology 2010;173(2):158-61.
2009: Mynthia Cabrera; Michelle F Paguio; Changan Xie; Paul D Roepe
Reduced digestive vacuolar accumulation of chloroquine is not linked to resistance to chloroquine toxicity.
Biochemistry 2009;48(47):11152-4.
2009: Mynthia Cabrera; Jayakumar Natarajan; Michelle F Paguio; Christian Wolf; Jeffrey S Urbach; Paul D Roepe
Chloroquine transport in Plasmodium falciparum. 1. Influx and efflux kinetics for live trophozoite parasites using a novel fluorescent chloroquine probe.
Biochemistry 2009;48(40):9471-81.
2009: Michelle F Paguio; Mynthia Cabrera; Paul D Roepe
Chloroquine transport in Plasmodium falciparum. 2. Analysis of PfCRT-mediated drug transport using proteoliposomes and a fluorescent chloroquine probe.
Biochemistry 2009;48(40):9482-91.
2009: Daniel P Iwaniuk; Eric D Whetmore; Nicholas Rosa; Kekeli Ekoue-Kovi; John Alumasa; Angel C De Dios; Paul D Roepe; Christian Wolf
Synthesis and antimalarial activity of new chloroquine analogues carrying a multifunctional linear side chain.
Bioorganic & medicinal chemistry 2009;17(18):6560-6.
2009: Paul D Roepe; Michael T Ferdig
P. falciparum Na(+)/H(+) exchanger (PfNHE) function and quinine resistance (QNR) [Reply to: Spillman et al. "Acid extrusion from the intraerythrocytic malaria parasite is not via a Na(+)/H(+) exchanger" Mol. Biochem. Parasitol. 2008 162 (1) 96-99].
Molecular and biochemical parasitology 2009;166(1):1-2; author reply 3.
2009: Paul D Roepe
Molecular and physiologic basis of quinoline drug resistance in Plasmodium falciparum malaria.
Future microbiology 2009;4(4):441-55.
2009: Leah B Casabianca; Joye B Kallgren; Jayakumar K Natarajan; John Alumasa; Paul D Roepe; Christian Wolf; Angel C De Dios
Antimalarial drugs and heme in detergent micelles: An NMR study.
Journal of inorganic biochemistry 2009;103(5):745-8.
2009: Yanpeng Hou; Shugeng Cao; Peggy J Brodie; Martin W Callmander; Fidy Ratovoson; Etienne A Rakotobe; Vincent E Rasamison; Michel Ratsimbason; John N Alumasa; Paul D Roepe; David G I Kingston
Antiproliferative and antimalarial anthraquinones of Scutia myrtina from the Madagascar forest.
Bioorganic & medicinal chemistry 2009;17(7):2871-6.
2009: Paul D Roepe
Malarial parasite pathogenesis and drug targets.
F1000 biology reports 2009;1():18.
2008: William H Witola; Kamal El Bissati; Gabriella Pessi; Changan Xie; Paul D Roepe; Choukri Ben Mamoun
Disruption of the Plasmodium falciparum PfPMT gene results in a complete loss of phosphatidylcholine biosynthesis via the serine-decarboxylase-phosphoethanolamine-methyltransferase pathway and severe growth and survival defects.
The Journal of biological chemistry 2008;283(41):27636-43.
2008: Jacqueline K Lekostaj; Jayakumar K Natarajan; Michelle F Paguio; Christian Wolf; Paul D Roepe
Photoaffinity labeling of the Plasmodium falciparum chloroquine resistance transporter with a novel perfluorophenylazido chloroquine.
Biochemistry 2008;47(39):10394-406.
2008: Leah B Casabianca; David An; Jayakumar K Natarajan; John Alumasa; Paul D Roepe; Christian Wolf; Angel C De Dios
Quinine and chloroquine differentially perturb heme monomer-dimer equilibrium.
Inorganic chemistry 2008;47(13):6077-81.
2008: Jayakumar K Natarajan; John Alumasa; Kimberly Yearick; Kekeli A Ekoue-Kovi; Leah B Casabianca; Angel C De Dios; Christian Wolf; Paul D Roepe
4-N-, 4-S-, and 4-O-chloroquine analogues: influence of side chain length and quinolyl nitrogen pKa on activity vs chloroquine resistant malaria.
Journal of medicinal chemistry 2008;51(12):3466-79.
2008: Bojana Gligorijevic; Kyle Purdy; David A Elliott; Roland A Cooper; Paul D Roepe
Stage independent chloroquine resistance and chloroquine toxicity revealed via spinning disk confocal microscopy.
Molecular and biochemical parasitology 2008;159(1):7-23.
2008: Kimberly Yearick; Kekeli Ekoue-Kovi; Daniel P Iwaniuk; Jayakumar K Natarajan; John Alumasa; Angel C De Dios; Paul D Roepe; Christian Wolf
Overcoming drug resistance to heme-targeted antimalarials by systematic side chain variation of 7-chloro-4-aminoquinolines.
Journal of medicinal chemistry 2008;51(7):1995-8.
2008: Jacqueline K Lekostaj; Linda E Amoah; Paul D Roepe
A single S1034C mutation confers altered drug sensitivity to PfMDR1 ATPase activity that is characteristic of the 7G8 isoform.
Molecular and biochemical parasitology 2008;157(1):107-11.
2007: Linda E Amoah; Jacqueline K Lekostaj; Paul D Roepe
Heterologous expression and ATPase activity of mutant versus wild type PfMDR1 protein.
Biochemistry 2007;46(20):6060-73.
2007: Tyler N Bennett; Jigar Patel; Michael T Ferdig; Paul D Roepe
Plasmodium falciparum Na+/H+ exchanger activity and quinine resistance.
Molecular and biochemical parasitology 2007;153(1):48-58.
2006: David C Reeves; David A Liebelt; Viswanathan Lakshmanan; Paul D Roepe; Fidock David; Myles H Akabas
Chloroquine-resistant isoforms of the Plasmodium falciparum chloroquine resistance transporter acidify lysosomal pH in HEK293 cells more than chloroquine-sensitive isoforms.
Molecular and biochemical parasitology 2006;150(2):288-99.
2006: Bojana Gligorijevic; Tyler Bennett; Ryan McAllister; Jeffrey S Urbach; Paul D Roepe
Spinning disk confocal microscopy of live, intraerythrocytic malarial parasites. 2. Altered vacuolar volume regulation in drug resistant malaria.
Biochemistry 2006;45(41):12411-23.
2006: Bojana Gligorijevic; Ryan McAllister; Jeffrey S Urbach; Paul D Roepe
Spinning disk confocal microscopy of live, intraerythrocytic malarial parasites. 1. Quantification of hemozoin development for drug sensitive versus resistant malaria.
Biochemistry 2006;45(41):12400-10.
2005: Tyler N Bennett; Andrew D Kosar; Paul D Roepe
Plasmodium falciparum strain GC-03 exhibits hyper-gametocytogenesis in partially hemoglobin depleted red blood cells.
Molecular and biochemical parasitology 2005;139(2):261-5.
2004: Angel C De Dios; Leah B Casabianca; Andrew D Kosar; Paul D Roepe
Structure of the amodiaquine-FPIX mu oxo dimer solution complex at atomic resolution.
Inorganic chemistry 2004;43(25):8078-84.
2004: Hanbang Zhang; Michelle Paguio; Paul D Roepe
The antimalarial drug resistance protein Plasmodium falciparum chloroquine resistance transporter binds chloroquine.
Biochemistry 2004;43(26):8290-6.
2004: Tyler N Bennett; Michelle Paguio; Bojana Gligorijevic; Clement Seudieu; Andrew D Kosar; Eugene Davidson; Paul D Roepe
Novel, rapid, and inexpensive cell-based quantification of antimalarial drug efficacy.
Antimicrobial agents and chemotherapy 2004;48(5):1807-10.
2004: Tyler N Bennett; Andrew D Kosar; Lyann M B Ursos; Sergey Dzekunov; Amar Bir Singh Sidhu; Fidock David; Paul D Roepe
Drug resistance-associated pfCRT mutations confer decreased Plasmodium falciparum digestive vacuolar pH.
Molecular and biochemical parasitology 2004;133(1):99-114.
2003: Karena L Waller; Rebecca A Muhle; Lyann M B Ursos; Paul Horrocks; Dominik Verdier-Pinard; Amar Bir Singh Sidhu; Hisashi Fujioka; Paul D Roepe; Fidock David
Chloroquine resistance modulated in vitro by expression levels of the Plasmodium falciparum chloroquine resistance transporter.
The Journal of biological chemistry 2003;278(35):33593-601.
2003: Ellen M Howard; Paul D Roepe
Purified human MDR 1 modulates membrane potential in reconstituted proteoliposomes.
Biochemistry 2003;42(12):3544-55.
2002: Hanbang Zhang; Ellen M Howard; Paul D Roepe
Analysis of the antimalarial drug resistance protein Pfcrt expressed in yeast.
The Journal of biological chemistry 2002;277(51):49767-75.
2002: Ellen M Howard; Hanbang Zhang; Paul D Roepe
A novel transporter, Pfcrt, confers antimalarial drug resistance.
The Journal of membrane biology 2002;190(1):1-8.
2002: Lyann M B Ursos; Paul D Roepe
Chloroquine resistance in the malarial parasite, Plasmodium falciparum.
Medicinal research reviews 2002;22(5):465-91.
2002: Alison Leed; Kateri DuBay; Lyann M B Ursos; Devin N Sears; Angel C De Dios; Paul D Roepe
Solution structures of antimalarial drug-heme complexes.
Biochemistry 2002;41(32):10245-55.
2002: Roland A Cooper; Michael T Ferdig; Xin-zhuan Su; Lyann M B Ursos; Jianbing Mu; Takashi Nomura; Hisashi Fujioka; Fidock David; Paul D Roepe; Thomas E Wellems
Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum.
Molecular pharmacology 2002;61(1):35-42.
2001: Rajeev K Mehlotra; Hisashi Fujioka; Paul D Roepe; O Janneh; Lyann M B Ursos; V Jacobs-Lorena; David T McNamara; Moses J Bockarie; James W Kazura; D E Kyle; Fidock David; Peter Zimmerman
Evolution of a unique Plasmodium falciparum chloroquine-resistance phenotype in association with pfcrt polymorphism in Papua New Guinea and South America.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(22):12689-94.
2001: Lyann M B Ursos; K F DuBay; Paul D Roepe
Antimalarial drugs influence the pH dependent solubility of heme via apparent nucleation phenomena.
Molecular and biochemical parasitology 2001;112(1):11-7.
2001: Paul D Roepe
pH and multidrug resistance.
Novartis Foundation symposium 2001;240():232-47; discussion 247-50, 265-8.
2000: Fidock David; Takashi Nomura; A K Talley; Roland A Cooper; Sergey Dzekunov; Michael T Ferdig; Lyann M B Ursos; Amar Bir Singh Sidhu; Bronwen Naudé; Kirk W Deitsch; Xin-zhuan Su; John C Wootton; Paul D Roepe; Thomas E Wellems
Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance.
Molecular cell 2000;6(4):861-71.
2000: Lyann M B Ursos; Sergey Dzekunov; Paul D Roepe
The effects of chloroquine and verapamil on digestive vacuolar pH of P. falciparum either sensitive or resistant to chloroquine.
Molecular and biochemical parasitology 2000;110(1):125-34.
2000: Sergey Dzekunov; Lyann M B Ursos; Paul D Roepe
Digestive vacuolar pH of intact intraerythrocytic P. falciparum either sensitive or resistant to chloroquine.
Molecular and biochemical parasitology 2000;110(1):107-24.
2000: Paul D Roepe
What is the precise role of human MDR 1 protein in chemotherapeutic drug resistance?
Current pharmaceutical design 2000;6(3):241-60.
1999: J H Weisburg; Paul D Roepe; Sergey Dzekunov; David A Scheinberg
Intracellular pH and multidrug resistance regulate complement-mediated cytotoxicity of nucleated human cells.
The Journal of biological chemistry 1999;274(16):10877-88.
1999: C T Santai; F Fritz; Paul D Roepe
Effects of ion gradients on H+ transport mediated by human MDR 1 protein.
Biochemistry 1999;38(13):4227-34.
1999: F Fritz; Ellen M Howard; MM Hoffman; Paul D Roepe
Evidence for altered ion transport in Saccharomyces cerevisiae overexpressing human MDR 1 protein.
Biochemistry 1999;38(13):4214-26.
1999: Paul D Roepe; J A Martiney
Are ion-exchange processes central to understanding drug-resistance phenomena?
Trends in pharmacological sciences 1999;20(2):62-5.
1999: JA Martiney; A S Ferrer; Anthony Cerami; S Dzekunov; Paul D Roepe
Chloroquine uptake, altered partitioning and the basis of drug resistance: evidence for chloride-dependent ionic regulation.
Novartis Foundation symposium 1999;226():265-77; discussion 277-80.
1998: Paul D Roepe
The P-glycoprotein efflux pump: how does it transport drugs?
The Journal of membrane biology 1998;166(1):71-3.
1997: L J Robinson; Wendy K Roberts; T T Ling; D Lamming; Stephen S Sternberg; Paul D Roepe
Human MDR 1 protein overexpression delays the apoptotic cascade in Chinese hamster ovary fibroblasts.
Biochemistry 1997;36(37):11169-78.
1997: MM Hoffman; Paul D Roepe
Analysis of ion transport perturbations caused by hu MDR 1 protein overexpression.
Biochemistry 1997;36(37):11153-68.
1997: L Y Wei; MM Hoffman; Paul D Roepe
Altered pHi regulation in 3T3/CFTR clones and their chemotherapeutic drug-selected derivatives.
The American journal of physiology 1997;272(5 Pt 1):C1642-53.
1997: R M Wadkins; Paul D Roepe
Biophysical aspects of P-glycoprotein-mediated multidrug resistance.
International review of cytology 1997;171():121-65.
1996: Paul D Roepe; L Y Wei; M M Hoffman; F Fritz
Altered drug translocation mediated by the MDR protein: direct, indirect, or both?
Journal of bioenergetics and biomembranes 1996;28(6):541-55.
1996: L J Robinson; Paul D Roepe
Effects of membrane potential versus pHi on the cellular retention of doxorubicin analyzed via a comparison between cystic fibrosis transmembrane conductance regulator (CFTR) and multidrug resistance (MDR) transfectants.
Biochemical pharmacology 1996;52(7):1081-95.
1996: M M Hoffman; L Y Wei; Paul D Roepe
Are altered pHi and membrane potential in hu MDR 1 transfectants sufficient to cause MDR protein-mediated multidrug resistance?
The Journal of general physiology 1996;108(4):295-313.
1996: J H Weisburg; M Curcio; P C Caron; G Raghu; Eugene Mechetner; Paul D Roepe; David A Scheinberg
The multidrug resistance phenotype confers immunological resistance.
The Journal of experimental medicine 1996;183(6):2699-704.
1995: Paul D Roepe
The role of the MDR protein in altered drug translocation across tumor cell membranes.
Biochimica et biophysica acta 1995;1241(3):385-405.
1995: L Y Wei; Monroe Stutts; M M Hoffman; Paul D Roepe
Overexpression of the cystic fibrosis transmembrane conductance regulator in NIH 3T3 cells lowers membrane potential and intracellular pH and confers a multidrug resistance phenotype.
Biophysical journal 1995;69(3):883-95.
1994: W G Bornmann; Paul D Roepe
Analysis of drug transport kinetics in multidrug-resistant cells using a novel coumarin-vinblastine compound.
Biochemistry 1994;33(42):12665-75.
1994: Paul D Roepe; J H Weisburg; J G Luz; M M Hoffman; L Y Wei
Novel Cl(-)-dependent intracellular pH regulation in murine MDR 1 transfectants and potential implications.
Biochemistry 1994;33(36):11008-15.
1994: J G Luz; L Y Wei; S Basu; Paul D Roepe
Transfection of mu MDR 1 inhibits Na(+)-independent Cl-/-HCO3 exchange in Chinese hamster ovary cells.
Biochemistry 1994;33(23):7239-49.
1994: L Y Wei; Paul D Roepe
Low external pH and osmotic shock increase the expression of human MDR protein.
Biochemistry 1994;33(23):7229-38.
1993: Paul D Roepe; L Y Wei; Cruz Jonathan; D Carlson
Lower electrical membrane potential and altered pHi homeostasis in multidrug-resistant (MDR) cells: further characterization of a series of MDR cell lines expressing different levels of P-glycoprotein.
Biochemistry 1993;32(41):11042-56.
1992: Paul D Roepe
Analysis of the steady-state and initial rate of doxorubicin efflux from a series of multidrug-resistant cells expressing different levels of P-glycoprotein.
Biochemistry 1992;31(50):12555-64.