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Chaim Roifman

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Eyal Grunebaum; Alan Daneman; Vy Hong-Diep Kim; David Manson; Luis Murguia-Favela; Chaim M Roifman; Michael Grunebaum
Multiple osteochondromas following irradiation-containing conditioning in severe combined immunodeficiency.
Vy Hong-Diep Kim; Luis Murguia; Eyal Grunebaum; Tal Schechter; Chaim M Roifman
Emergency treatment for ζ chain-associated protein of 70 kDa (ZAP70) deficiency.
Pietro Luigi Poliani; Chaim M Roifman; Elena Fontana; Luigi D Notarangelo
ζ Chain-associated protein of 70 kDa (ZAP70) deficiency in human subjects is associated with abnormalities of thymic stromal cells: Implications for T-cell tolerance.

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2013: Eyal Grunebaum; Alan Daneman; Vy Hong-Diep Kim; David Manson; Luis Murguia-Favela; Chaim M Roifman; Michael Grunebaum
Multiple osteochondromas following irradiation-containing conditioning in severe combined immunodeficiency.
British journal of haematology 2013;161(3):446-8.
2013: Vy Hong-Diep Kim; Luis Murguia; Eyal Grunebaum; Tal Schechter; Chaim M Roifman
Emergency treatment for ζ chain-associated protein of 70 kDa (ZAP70) deficiency.
The Journal of allergy and clinical immunology 2013;131(4):1233-5.
2013: Pietro Luigi Poliani; Chaim M Roifman; Elena Fontana; Luigi D Notarangelo
ζ Chain-associated protein of 70 kDa (ZAP70) deficiency in human subjects is associated with abnormalities of thymic stromal cells: Implications for T-cell tolerance.
The Journal of allergy and clinical immunology 2013;131(2):597-600.e1-2.
2013: Miguel Muñoz-Ruiz; Verónica Pérez-Flores; María J Recio; Chaim M Roifman; Ozden Sanal; Hidetoshi Takada; Luis M Allende; Edgar Fernández-Malavé; Beatriz Garcillán; Alberto C Guardo; Sara S Kilic; Eduardo López-Granados; Eduardo Martínez-Naves; Marina S Mazariegos; José R Regueiro
Human CD3γ, but not CD3δ, haploinsufficiency differentially impairs γδ versus αβ surface TCR expression.
BMC immunology 2013;14():3.
2013: Tal Schechter; Xiuyan Zhao; Laura Avila; Jennifer Domm; L Lee Dupuis; Haydar Frangoul; Adam Gassas; Rahul Naithani; Stacey Pollock-Barziv; Chaim M Roifman; John Doyle
Effect of acute graft-versus-host disease on the outcome of second allogeneic hematopoietic stem cell transplant in children.
Leukemia & lymphoma 2013;54(1):105-9.
2013: Christopher J Moran; Marialena Mouzaki; Chaim M Roifman; Mark S Silverberg; Scott B Snapper; Dan Turner; Thomas D Walters; Victorien M Wolters; Mary Zachos; Robert H Bandsma; Susanne M Benseler; Ernest Cutz; Anne M Griffiths; Cong-Hui Guo; Christoph Klein; Subra Kugathasan; Jacob C Langer; Aleixo M Muise
IL-10R polymorphisms are associated with very-early-onset ulcerative colitis.
Inflammatory bowel diseases 2013;19(1):115-23.
2012: Sandra Weller; Shen-Ying Zhang; Simona Eva Zitnik; Carlos Rodrigo; Carlos Rodriguez-Gallego; Chaim M Roifman; Júlia Vasconcelos; Jean-Claude Weill; Alexandre Alcais; Peter Arkwright; Mélanie Bonnet; Yildiz Camcioglu; Jean-Laurent Casanova; Andrea Cerutti; Maya Chrabieh; Héloïse Delagreverie; Ben-Zion Garty; Cyrille Hoarau; Laura Israel; Andrew C Issekutz; László Maródi; Eric Meffre; Capucine Picard; Anne Puel; Claude-Agnès Reynaud
IgM+IgD+CD27+ B cells are markedly reduced in IRAK-4-, MyD88-, and TIRAP- but not UNC-93B-deficient patients.
Blood 2012;120(25):4992-5001.
2012: Alireza Mansouri; Weixian Min; Matthijs van Eede; Cameron Ackerley; Christina J Cole; Eyal Grunebaum; Jeffrey Theodore Henderson; R Mark Henkelman; Sheena A Josselyn; Chaim M Roifman
Cerebellar abnormalities in purine nucleoside phosphorylase deficient mice.
Neurobiology of disease 2012;47(2):201-9.
2012: Chaim M Roifman; Raz Somech; Ilan Dalal; Fotini Kavadas; Amit Nahum; Linda Pires; Eyal Grunebaum
Defining combined immunodeficiency.
The Journal of allergy and clinical immunology 2012;130(1):177-83.
2012: Eyal Grunebaum; Ernest Cutz; Chaim M Roifman
Pulmonary alveolar proteinosis in patients with adenosine deaminase deficiency.
The Journal of allergy and clinical immunology 2012;129(6):1588-93.
2012: Amit Nahum; Andrea Bates; Harjit Dadi; Chaim M Roifman
The biological significance of TLR3 variant, L412F, in conferring susceptibility to cutaneous candidiasis, CMV and autoimmunity.
Autoimmunity reviews 2012;11(5):341-7.
2011: Nufar Marcus; Diego Plaza Lopez de Sabando; Jose R Regueiro; William T Shearer; Hidetoshi Takada; Morton J Cowan; Jignesh Dalal; Wilhelm Friedrich; Juana Gil; Eyal Grunebaum; Imelda Celine Hanson; Jason Law; Eduardo Lopez-Granados; Hoenig Manfred; Chaim M Roifman
Hematopoietic stem cell transplantation for CD3δ deficiency.
The Journal of allergy and clinical immunology 2011;128(5):1050-7.
2011: Vicki Modell; Luigi D Notarangelo; Jordan S Orange; Chaim M Roifman; John M Routes; Ricardo U Sorensen; Bonnie Gee; David B Lewis; Fred Modell
Global study of primary immunodeficiency diseases (PI)--diagnosis, treatment, and economic impact: an updated report from the Jeffrey Modell Foundation.
Immunologic research 2011;51(1):61-70.
2011: Taniya Papinazath; Chaim M Roifman; Suntharalingam Sujiththa; Cameron Ackerley; Amos Cohen; Wexian Min; Eyal Grunebaum
Effects of purine nucleoside phosphorylase deficiency on thymocyte development.
The Journal of allergy and clinical immunology 2011;128(4):854-863.e1.
2011: Mary A Barron; Eyal Grunebaum; Lorrie E M Hagen; Melanie Makhija; Paul Pencharz; Chaim M Roifman
Increased resting energy expenditure is associated with failure to thrive in infants with severe combined immunodeficiency.
The Journal of pediatrics 2011;159(4):628-32.e1.
2011: E Tsangaris; R Yanofsky; S Abish; K Ali; C Allen; Uma H Athale; Joseph Beyene; J Brossard; Patricia Canning; Manuel Carcao; J Champagne; N Dower; Conrad V Fernandez; J P Hand; L Jardine; R Klaassen; J H Lipton; B Michon; Isaac Odame; Chaim M Roifman; E Shereck; Mariana Silva; M Steele; Yigal Dror
Genetic analysis of inherited bone marrow failure syndromes from one prospective, comprehensive and population-based cohort and identification of novel mutations.
Journal of medical genetics 2011;48(9):618-28.
2011: Eyal Grunebaum; Catherine T-S Chung; Harjit Dadi; Peter Kim; Immacolata Brigida; Francesca Ferrua; Maria P Cicalese; Alessandro Aiuti; Chaim M Roifman
Purine metabolism, immune reconstitution, and abdominal adipose tumor after gene therapy for adenosine deaminase deficiency.
The Journal of allergy and clinical immunology 2011;127(6):1417-9.e3.
2011: Sarah Nicholas; Robert A Krance; I Celine Hanson; Javier Chinen; Robert J Mamlok; Chaim M Roifman; William T Shearer
Early versus delayed diagnosis of SCID: triumph versus tragedy.
Clinical immunology (Orlando, Fla.) 2011;139(3):360-2.
2011: Eyal Grunebaum; Chaim M Roifman
Bone marrow transplantation using HLA-matched unrelated donors for patients suffering from severe combined immunodeficiency.
Hematology/oncology clinics of North America 2011;25(1):63-73.
2011: Andrea Newell; Harjit Dadi; Rachel Goldberg; Bo-Yee Ngan; Eyal Grunebaum; Chaim M Roifman
Diffuse large B-cell lymphoma as presenting feature of Zap-70 deficiency.
The Journal of allergy and clinical immunology 2011;127(2):517-20.
2011: Amit Nahum; Harjit Dadi; Andrea Bates; Chaim M Roifman
The L412F variant of Toll-like receptor 3 (TLR3) is associated with cutaneous candidiasis, increased susceptibility to cytomegalovirus, and autoimmunity.
The Journal of allergy and clinical immunology 2011;127(2):528-31.
2011: Waleed Al-Herz; Aziz Bousfiha; Jean-Laurent Casanova; Helen Chapel; Mary Ellen Conley; Charlotte Cunningham-Rundles; Amos Etzioni; Alain Fischer; Jose Luis Franco; Raif S Geha; Lennart Hammarström; Shigeaki Nonoyama; Luigi Daniele Notarangelo; Hans Dieter Ochs; Jennifer M Puck; Chaim M Roifman; Reinhard Seger; Mimi L K Tang
Primary immunodeficiency diseases: an update on the classification from the international union of immunological societies expert committee for primary immunodeficiency.
Frontiers in immunology 2011;2():54.
2010: Chaim M Roifman; Harjit Dadi; Raz Somech; Amit Nahum; Nigel Sharfe
Characterization of ζ-associated protein, 70 kd (ZAP70)-deficient human lymphocytes.
The Journal of allergy and clinical immunology 2010;126(6):1226-33.e1.
2010: Nashat Al-Sukaiti; Brenda Reid; Sasson Lavi; Daifulah Al-Zaharani; Adelle Atkinson; Chaim M Roifman; Eyal Grunebaum
Safety and efficacy of measles, mumps, and rubella vaccine in patients with DiGeorge syndrome.
The Journal of allergy and clinical immunology 2010;126(4):868-9.
2010: Chaim M Roifman; Alain Fischer; Luigi D Notarangelo; M Teresa de la Morena; Reinhard A Seger
Indications for hemopoietic stem cell transplantation.
Immunology and allergy clinics of North America 2010;30(2):261-2.
2010: Chaim M Roifman
Hematopoietic stem cell transplantation for profound T-cell deficiency (combined immunodeficiency).
Immunology and allergy clinics of North America 2010;30(2):209-19.
2010: Chaim M Roifman
Each condition should be carefully studied, ideally with homogenous patient groups. Preface.
Immunology and allergy clinics of North America 2010;30(2):xi.
2010: Eyal Grunebaum; Chaim M Roifman
Bone marrow transplantation using HLA-matched unrelated donors for patients suffering from severe combined immunodeficiency.
Immunology and allergy clinics of North America 2010;30(1):63-73.
2010: Chaim M Roifman
Preface.
Immunology and allergy clinics of North America 2010;30(1):xiii-xiv.
2009: Linda M Griffith; Morton J Cowan; Luigi D Notarangelo; Jennifer M Puck; Rebecca H Buckley; Fabio Candotti; Mary Ellen Conley; Thomas A Fleisher; H Bobby Gaspar; Donald B Kohn; Hans D Ochs; Richard J O'Reilly; J Douglas Rizzo; Chaim M Roifman; Trudy N Small; William T Shearer
Improving cellular therapy for primary immune deficiency diseases: recognition, diagnosis, and management.
The Journal of allergy and clinical immunology 2009;124(6):1152-60.e12.
2009: Chaim M Roifman; D Chitayat
Combined immunodeficiency, facial dysmorphism, optic nerve atrophy, skeletal anomalies and developmental delay: a new syndrome.
Clinical genetics 2009;76(5):449-57.
2009: Yongmao Yu; Alka Arora; Weixian Min; Chaim M Roifman; Eyal Grunebaum
EdU incorporation is an alternative non-radioactive assay to [(3)H]thymidine uptake for in vitro measurement of mice T-cell proliferations.
Journal of immunological methods 2009;350(1-2):29-35.
2009: Aisha V Sauer; Emanuela Mrak; Raisa Jofra Hernandez; Elena Zacchi; Francesco Cavani; Monica Casiraghi; Eyal Grunebaum; Chaim M Roifman; Maria C Cervi; alessandro ambrosi; Filippo Carlucci; Maria-Grazia Roncarolo; Anna Villa; Alessandro Rubinacci; Alessandro Aiuti
ADA-deficient SCID is associated with a specific microenvironment and bone phenotype characterized by RANKL/OPG imbalance and osteoblast insufficiency.
Blood 2009;114(15):3216-26.
2009: Raz Somech; Amos J Simon; Atar Lev; Ilan Dalal; Zvi Spirer; Itamar Goldstein; Meital Nagar; Ninette Amariglio; Gideon Rechavi; Chaim M Roifman
Reduced central tolerance in Omenn syndrome leads to immature self-reactive oligoclonal T cells.
The Journal of allergy and clinical immunology 2009;124(4):793-800.
2009: Raz Somech; Yew Hon Lai; Eyal Grunebaum; Nicole Le Saux; Ernest Cutz; Chaim M Roifman
Polyethylene glycol-modified adenosine deaminase improved lung disease but not liver disease in partial adenosine deaminase deficiency.
The Journal of allergy and clinical immunology 2009;124(4):848-50.
2009: Paola Angelini; Fotini Kavadas; Navneet Sharma; Susan E Richardson; Graham A Tipples; Chaim M Roifman; Yigal Dror; Yehuda Nofech-Mozes
Aplastic anemia following varicella vaccine.
The Pediatric infectious disease journal 2009;28(8):746-8.
2009: Pietro Luigi Poliani; Fabio Facchetti; Maria Ravanini; Andrew Richard Gennery; Anna Villa; Chaim M Roifman; Luigi D Notarangelo
Early defects in human T-cell development severely affect distribution and maturation of thymic stromal cells: possible implications for the pathophysiology of Omenn syndrome.
Blood 2009;114(1):105-8.
2009: Amit Nahum; Brenda Reid; Eyal Grunebaum; Chaim M Roifman
Matched unrelated bone marrow transplant for Omenn syndrome.
Immunologic research 2009;44(1-3):25-34.
2008: Luigi D Notarangelo; Chaim M Roifman; Silvia Giliani
Cartilage-hair hypoplasia: molecular basis and heterogeneity of the immunological phenotype.
Current opinion in allergy and clinical immunology 2008;8(6):534-9.
2008: Pu Liao; Ana Toro; Weixian Min; Shaun Lee; Chaim M Roifman; Eyal Grunebaum
Lentivirus gene therapy for purine nucleoside phosphorylase deficiency.
The journal of gene medicine 2008;10(12):1282-93.
2008: Chaim M Roifman; Melvin Berger; Luigi D Notarangelo
Management of primary antibody deficiency with replacement therapy: summary of guidelines.
Immunology and allergy clinics of North America 2008;28(4):875-6, x.
2008: Stephen K Membe; Chuong Ho; Karen Cimon; Andra Morrison; Amin Kanani; Chaim M Roifman
Economic assessment of different modalities of immunoglobulin replacement therapy.
Immunology and allergy clinics of North America 2008;28(4):861-74, x.
2008: Chaim M Roifman
Intravenous immunoglobulin treatment of immunodeficiency. Preface.
Immunology and allergy clinics of North America 2008;28(4):xv-xvi.
2008: Chaim M Roifman; Junyan Zhang; Adelle Atkinson; Eyal Grunebaum; Karen Mandel
Adenosine deaminase deficiency can present with features of Omenn syndrome.
The Journal of allergy and clinical immunology 2008;121(4):1056-8.
2008: Nigel Sharfe; Martina Nikolic; Lorand Cimpeon; Alison Van De Kratts; Andrew Freywald; Chaim M Roifman
EphA and ephrin-A proteins regulate integrin-mediated T lymphocyte interactions.
Molecular immunology 2008;45(5):1208-20.
2008: Sean R Bulley; Lee Benson; Eyal Grunebaum; Chaim M Roifman
Cardiac chamber hypertrophy following hematopoietic stem cell transplantation for primary immunodeficiency.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2008;14(2):229-35.
2008: Raz Somech; Gino R Somers; David Chitayat; Eyal Grunebaum; Adelle Atkinson; Elena Kolomietz; Chaim M Roifman
Fatal lung fibrosis associated with immunodeficiency and gonadal dysgenesis in 46XX sisters--a new syndrome.
American journal of medical genetics. Part A 2008;146A(1):8-14.
2007: Raif S Geha; Luigi D Notarangelo; Jean-Laurent Casanova; Helen Chapel; Mary Ellen Conley; Alain Fischer; Lennart Hammarström; Shigeaki Nonoyama; Hans D Ochs; Jennifer M Puck; Chaim M Roifman; Reinhard Seger; Josiah Wedgwood
Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee.
The Journal of allergy and clinical immunology 2007;120(4):776-94.
2007: Elana Lavine; Raz Somech; Jun Yan Zhang; Anne Puel; Xavier Bossuyt; Capucine Picard; Jean-Laurent Casanova; Chaim M Roifman
Cellular and humoral aberrations in a kindred with IL-1 receptor-associated kinase 4 deficiency.
The Journal of allergy and clinical immunology 2007;120(4):948-50.
2007: Yehuda Nofech-Mozes; Susan I Blaser; Jeff Kobayashi; Eyal Grunebaum; Chaim M Roifman
Neurologic abnormalities in patients with adenosine deaminase deficiency.
Pediatric neurology 2007;37(3):218-21.
2007: Adelle R Atkinson; Chaim M Roifman
Low serum immunoglobulin G2 levels in infancy can be transient.
Pediatrics 2007;120(3):e543-7.
2007: Maitham Husain; Eyal Grunebaum; Ahmed Naqvi; Adelle Atkinson; Bo-Yee Ngan; Alessandro Aiuti; Chaim M Roifman
Burkitt's lymphoma in a patient with adenosine deaminase deficiency-severe combined immunodeficiency treated with polyethylene glycol-adenosine deaminase.
The Journal of pediatrics 2007;151(1):93-5.
2007: Chaim M Roifman; Eyal Grunebaum; Ilan Dalal; Luigi D Notarangelo
Matched unrelated bone marrow transplant for severe combined immunodeficiency.
Immunologic research 2007;38(1-3):191-200.
2006: R Guggenheim; Raz Somech; Eyal Grunebaum; Adelle Atkinson; Chaim M Roifman
Bone marrow transplantation for cartilage-hair-hypoplasia.
Bone marrow transplantation 2006;38(11):751-6.
2006: Christopher A Aoki; Chaim M Roifman; Zhe-Xiong Lian; Christopher L Bowlus; Gary L Norman; Yehuda Shoenfeld; Ian R Mackay; M Eric Gershwin
IL-2 receptor alpha deficiency and features of primary biliary cirrhosis.
Journal of autoimmunity 2006;27(1):50-3.
2006: Luigi D Notarangelo; Jean-Laurent Casanova; Mary Ellen Conley; Helen Chapel; Alain Fischer; Jennifer M Puck; Chaim M Roifman; Reinhard Seger; Raif S Geha
Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee Meeting in Budapest, 2005.
The Journal of allergy and clinical immunology 2006;117(4):883-96.
2006: Chaim M Roifman; Yiping Gu; Amos Cohen
Mutations in the RNA component of RNase mitochondrial RNA processing might cause Omenn syndrome.
The Journal of allergy and clinical immunology 2006;117(4):897-903.
2006: Andrew Freywald; Nigel Sharfe; Charlotte D'E Miller; Cher Rashotte; Chaim M Roifman
EphA receptors inhibit anti-CD3-induced apoptosis in thymocytes.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(7):4066-74.
2006: Eyal Grunebaum; Evelina Mazzolari; Fulvio Porta; Daniela Dallera; Adelle Atkinson; Brenda Reid; Luigi D Notarangelo; Chaim M Roifman
Bone marrow transplantation for severe combined immune deficiency.
JAMA : the journal of the American Medical Association 2006;295(5):508-18.
2006: Eyal Grunebaum; Nigel Sharfe; Chaim M Roifman
Human T cell immunodeficiency: when signal transduction goes wrong.
Immunologic research 2006;35(1-2):117-26.
2006: Uwe Nicolay; Peter Kiessling; Melvin Berger; Sudhir Gupta; Leman Yel; Chaim M Roifman; Ann Gardulf; Florian Eichmann; Stefan Haag; Cordula Massion; Hans D Ochs
Health-related quality of life and treatment satisfaction in North American patients with primary immunedeficiency diseases receiving subcutaneous IgG self-infusions at home.
Journal of clinical immunology 2006;26(1):65-72.
2005: Kun Yang; Anne Puel; Shenying Zhang; Céline Eidenschenk; Cheng-Lung KU; Armanda Casrouge; Capucine Picard; Horst von Bernuth; Brigitte Senechal; Sabine Plancoulaine; Sami Al-Hajjar; Abdulaziz Al-Ghonaium; László Maródi; Donald Davidson; David P Speert; Chaim M Roifman; Ben-Zion Garty; Adrian Ozinsky; Franck J Barrat; Robert L Coffman; Richard L Miller; Xiaoxia Li; Pierre Lebon; Carlos Rodriguez-Gallego; Helen Chapel; Frederic Geissmann; Emmanuelle Jouanguy; Jean-Laurent Casanova
Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses.
Immunity 2005;23(5):465-78.
2005: Raz Somech; Chaim M Roifman
Mutation analysis should be performed to rule out gammac deficiency in children with functional severe combined immune deficiency despite apparently normal immunologic tests.
The Journal of pediatrics 2005;147(4):555-7.
2005: Junyan Zhang; Linda Quintal; Adelle Atkinson; Brent Williams; Eyal Grunebaum; Chaim M Roifman
Novel RAG1 mutation in a case of severe combined immunodeficiency.
Pediatrics 2005;116(3):e445-9.
2005: Hidetoshi Takada; Akihiko Nomura; Chaim M Roifman; Toshiro Hara
Severe combined immunodeficiency caused by a splicing abnormality of the CD3delta gene.
European journal of pediatrics 2005;164(5):311-4.
2005: Chaim M Roifman
Studies of patients' thymi aid in the discovery and characterization of immunodeficiency in humans.
Immunological reviews 2005;203():143-55.
2004: Chaim M Roifman
CD3 delta immunodeficiency.
Current opinion in allergy and clinical immunology 2004;4(6):479-84.
2004: Eyal Grunebaum; Junyang Zhang; Chaim M Roifman
Novel mutations and hot-spots in patients with purine nucleoside phosphorylase deficiency.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1411-5.
2004: Chaim M Roifman
Signals find their target: drug design and diagnosis based on intracellular signalling.
Clinical and investigative medicine. Médecine clinique et experimentale 2004;27(5):282-4.
2004: Peter Demin; Olga Rounova; Thomas Grunberger; Lorand Cimpean; Nigel Sharfe; Chaim M Roifman
Tyrenes: synthesis of new antiproliferative compounds with an extended conjugation.
Bioorganic & medicinal chemistry 2004;12(11):3019-26.
2004: Yigal Dror; Eyal Grunebaum; Johann K Hitzler; Aru Narendran; Charles Ye; Raymond Tellier; Vernon Edwards; Melvin H Freedman; Chaim M Roifman
Purine nucleoside phosphorylase deficiency associated with a dysplastic marrow morphology.
Pediatric research 2004;55(3):472-7.
2003: Thomas Grunberger; Peter Demin; Olga Rounova; Nigel Sharfe; Lorand Cimpean; Harjit Dadi; Andrew Freywald; Zeev Estrov; Chaim M Roifman
Inhibition of acute lymphoblastic and myeloid leukemias by a novel kinase inhibitor.
Blood 2003;102(12):4153-8.
2003: Harjit Dadi; Amos J Simon; Chaim M Roifman
Effect of CD3delta deficiency on maturation of alpha/beta and gamma/delta T-cell lineages in severe combined immunodeficiency.
The New England journal of medicine 2003;349(19):1821-8.
2003: Chaim M Roifman; Harry Schroeder; Melvin Berger; Ricardo U Sorensen; Mark Ballow; Rebecca H Buckley; Anita Gewurz; Phillip Korenblat; Gordon Sussman; Georg Lemm
Comparison of the efficacy of IGIV-C, 10% (caprylate/chromatography) and IGIV-SD, 10% as replacement therapy in primary immune deficiency. A randomized double-blind trial.
International immunopharmacology 2003;3(9):1325-33.
2003: Wenwen Chien; Nicola Tidow; Elizabeth A Williamson; Lee-Yung Shih; Utz Krug; Arminja Kettenbach; Anthony C Fermin; Chaim M Roifman; H Phillip Koeffler
Characterization of a myeloid tyrosine phosphatase, Lyp, and its role in the Bcr-Abl signal transduction pathway.
The Journal of biological chemistry 2003;278(30):27413-20.
2003: Nigel Sharfe; Andrew Freywald; Ana Toro; Chaim M Roifman
Ephrin-A1 induces c-Cbl phosphorylation and EphA receptor down-regulation in T cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(12):6024-32.
2003: Chaim M Roifman; I Melamed
A novel syndrome of combined immunodeficiency, autoimmunity and spondylometaphyseal dysplasia.
Clinical genetics 2003;63(6):522-9.
2003: Yiping Gu; Chunjie Wang; Chaim M Roifman; Amos Cohen
Role of MHC class I in immune surveillance of mitochondrial DNA integrity.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(7):3603-7.
2003: Andrew Freywald; Nigel Sharfe; Cher Rashotte; Thomas Grunberger; Chaim M Roifman
The EphB6 receptor inhibits JNK activation in T lymphocytes and modulates T cell receptor-mediated responses.
The Journal of biological chemistry 2003;278(12):10150-6.
2002: Nigel Sharfe; Andrew Freywald; Ana Toro; Harjit Dadi; Chaim M Roifman
Ephrin stimulation modulates T cell chemotaxis.
European journal of immunology 2002;32(12):3745-55.
2002: Eyal Grunebaum; Chaim M Roifman
Gene abnormalities in patients with hemophagocytic lymphohistiocytosis.
The Israel Medical Association journal : IMAJ 2002;4(5):366-9.
2002: Andrew Freywald; Nigel Sharfe; Chaim M Roifman
The kinase-null EphB6 receptor undergoes transphosphorylation in a complex with EphB1.
The Journal of biological chemistry 2002;277(6):3823-8.
2001: Yigal Dror; Hedy H Ginzberg; Ilan Dalal; Vera Cherepanov; G Downey; Peter Roy Durie; Chaim M Roifman; Melvin H Freedman
Immune function in patients with Shwachman-Diamond syndrome.
British journal of haematology 2001;114(3):712-7.
2001: Ilan Dalal; Eyal Grunebaum; Amos Cohen; Chaim M Roifman
Two novel mutations in a purine nucleoside phosphorylase (PNP)-deficient patient.
Clinical genetics 2001;59(6):430-7.
2001: Eyal Grunebaum; Enrico Arpaia; J J MacKenzie; J Fitzpatrick; P N Ray; Chaim M Roifman
A missense mutation in the SEDL gene results in delayed onset of X linked spondyloepiphyseal dysplasia in a large pedigree.
Journal of medical genetics 2001;38(6):409-11.
2001: Eyal Grunebaum; Chaim M Roifman
Signal-transduction defects in T cells.
Clinical reviews in allergy & immunology 2001;20(1):27-42.
2000: Chaim M Roifman; J Zhang; David Chitayat; Nigel Sharfe
A partial deficiency of interleukin-7R alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiency.
Blood 2000;96(8):2803-7.
2000: David Manson; S Sikka; B Reid; Chaim M Roifman
Primary immunodeficiencies: a pictorial immunology primer for radiologists.
Pediatric radiology 2000;30(8):501-10.
2000: Enrico Arpaia; P Benveniste; Antonio Di Cristofano; Y Gu; Ilan Dalal; S Kelly; M Hershfield; P P Pandolfi; Chaim M Roifman; Amos Cohen
Mitochondrial basis for immune deficiency. Evidence from purine nucleoside phosphorylase-deficient mice.
The Journal of experimental medicine 2000;191(12):2197-208.
2000: Orna Diav-Citrin; Savithiri Ratnapalan; M Grouhi; Chaim M Roifman; Gideon Koren
Medication errors in paediatrics: a case report and systematic review of risk factors.
Paediatric drugs 2000;2(3):239-42.
2000: Eyal Grunebaum; J Zhang; Harjit Dadi; Chaim M Roifman
Haemophagocytic lymphohistiocytosis in X-linked severe combined immunodeficiency.
British journal of haematology 2000;108(4):834-7.
2000: Ilan Dalal; B Reid; John Doyle; M Freedman; Stan Calderwood; Frederick E Saunders; Chaim M Roifman
Matched unrelated bone marrow transplantation for combined immunodeficiency.
Bone marrow transplantation 2000;25(6):613-21.
2000: Enrico Arpaia; Y Gu; Ilan Dalal; S Kelly; M Hershfield; Chaim M Roifman; Amos Cohen
Biochemical and immunological abnormalities in purine nucleoside phosphorylase deficient mice.
Advances in experimental medicine and biology 2000;486():41-5.
1999: M Grouhi; M Alshehri; D Hummel; Chaim M Roifman
Anaphylaxis and epinephrine auto-injector training: who will teach the teachers?
The Journal of allergy and clinical immunology 1999;104(1):190-3.
1999: M Grouhi; D Hummel; Chaim M Roifman
Anaphylactic reaction to oral cefaclor in a child.
Pediatrics 1999;103(4):e50.
1999: S Cohen; Harjit Dadi; E Shaoul; Nigel Sharfe; Chaim M Roifman
Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp.
Blood 1999;93(6):2013-24.
1999: M Grouhi; E Wang; B Reid; Chaim M Roifman
Long-term remission for disseminated Mycobacterium avium-intracellulare complex associated with antibody deficiency.
Pediatrics 1999;103(1):E13.
1998: M Grouhi; Ilan Dalal; Eric Nisbet-Brown; Chaim M Roifman
Cerebral vasculitis associated with chronic mucocutaneous candidiasis.
The Journal of pediatrics 1998;133(4):571-4.
1998: Ilan Dalal; B Reid; Eric Nisbet-Brown; Chaim M Roifman
The outcome of patients with hypogammaglobulinemia in infancy and early childhood.
The Journal of pediatrics 1998;133(1):144-6.
1998: Ilan Dalal; Enrico Arpaia; Harjit Dadi; S Kulkarni; J Squire; Chaim M Roifman
Cloning and characterization of the human homolog of mouse Jak2.
Blood 1998;91(3):844-51.
1997: Nigel Sharfe; M Shahar; Chaim M Roifman
An interleukin-2 receptor gamma chain mutation with normal thymus morphology.
The Journal of clinical investigation 1997;100(12):3036-43.
1997: David Manson; B Reid; Ilan Dalal; Chaim M Roifman
Clinical utility of high-resolution pulmonary computed tomography in children with antibody deficiency disorders.
Pediatric radiology 1997;27(10):794-8.
1997: R Loebstein; Ilan Dalal; Eric Nisbet-Brown; M Berkovitch; N Meydan; D Andrews; M D Loubser; Gideon Koren; Chaim M Roifman; Nancy F Olivieri
Immune function in patients with beta thalassaemia receiving the orally active iron-chelating agent deferiprone.
British journal of haematology 1997;98(3):597-600.
1997: Nigel Sharfe; Chaim M Roifman
Differential association of phosphatidylinositol 3-kinase with insulin receptor substrate (IRS)-1 and IRS-2 in human thymocytes in response to IL-7.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(3):1107-14.
1997: Nigel Sharfe; Harjit Dadi; John O'Shea; Chaim M Roifman
Jak3 activation in human lymphocyte precursor cells.
Clinical and experimental immunology 1997;108(3):552-6.
1997: Nigel Sharfe; Harjit Dadi; M Shahar; Chaim M Roifman
Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptor.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(7):3168-71.
1997: S Nadarajah; Bernice R Krafchik; Chaim M Roifman; C Horgan-Bell
Treatment of hypereosinophilic syndrome in a child using cyclosporine: implication for a primary T-cell abnormality.
Pediatrics 1997;99(4):630-3.
1996: N Meydan; T Grunberger; Harjit Dadi; M Shahar; E Arpaia; Z Lapidot; J S Leeder; M Freedman; A Cohen; A Gazit; A Levitzki; Chaim M Roifman
Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor.
Nature 1996;379(6566):645-8.
1995: Chaim M Roifman
A mutation in zap-70 protein tyrosine kinase results in a selective immunodeficiency.
Journal of clinical immunology 1995;15(6 Suppl):52S-62S.
1995: Chaim M Roifman
Use of intravenous immune globulin in the therapy of children with rheumatological diseases.
Journal of clinical immunology 1995;15(6 Suppl):42S-51S.
1995: B Trink; G Wang; M Shahar; N Meydan; Chaim M Roifman
Functional platelet-derived growth factor-beta (PDGF-beta) receptor expressed on early B-lineage precursor cells.
Clinical and experimental immunology 1995;102(2):417-24.
1995: Nigel Sharfe; Harjit Dadi; Chaim M Roifman
JAK3 protein tyrosine kinase mediates interleukin-7-induced activation of phosphatidylinositol-3' kinase.
Blood 1995;86(6):2077-85.
1995: Leonard Stein; Chaim M Roifman
Intravenous immunoglobulin therapy.
Bulletin on the rheumatic diseases 1995;44(4):3-5.
1995: Chaim M Roifman
Selection transduction defect (STD) due to Zap-70 kinase deficiency.
Immunodeficiency 1995;5(3):193-211.
1994: I Melamed; Leonard Stein; Chaim M Roifman
Epstein-Barr virus induces actin polymerization in human B cells.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(5):1998-2003.
1994: Harjit Dadi; S Ke; Chaim M Roifman
Activation of phosphatidylinositol-3 kinase by ligation of the interleukin-7 receptor is dependent on protein tyrosine kinase activity.
Blood 1994;84(5):1579-86.
1994: A J Cohen; Chaim M Roifman; J Brendan; M Mullen; B Reid; Gordon L Weisbrod; G P Downey
Localised pulmonary resection for bronchiectasis in hypogammaglobulinaemic patients.
Thorax 1994;49(5):509-10.
1994: E Arpaia; M Shahar; Harjit Dadi; A Cohen; Chaim M Roifman
Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase.
Cell 1994;76(5):947-58.
1994: I Melamed; A Cohen; Chaim M Roifman
Expansion of CD3+CD4-CD8- T cell population expressing high levels of IL-5 in Omenn's syndrome.
Clinical and experimental immunology 1994;95(1):14-21.
1993: Harjit Dadi; Chaim M Roifman
Activation of phosphatidylinositol-3 kinase by ligation of the interleukin-7 receptor on human thymocytes.
The Journal of clinical investigation 1993;92(3):1559-63.
1993: Chaim M Roifman; S Ke
CD19 is a substrate of the antigen receptor-associated protein tyrosine kinase in human B cells.
Biochemical and biophysical research communications 1993;194(1):222-5.
1993: Harjit Dadi; S Ke; Chaim M Roifman
Interleukin 7 receptor mediates the activation of phosphatidylinositol-3 kinase in human B-cell precursors.
Biochemical and biophysical research communications 1993;192(2):459-64.
1992: Chaim M Roifman; G Wang
Receptor-mediated activation of human B lymphocytes in a nonphosphotyrosine-dependent manner.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(4):1179-84.
1992: I Melamed; G Wang; Chaim M Roifman
Antigen receptor-mediated protein tyrosine kinase activity is regulated by a pertussis toxin-sensitive G protein.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(1):169-74.
1992: Chaim M Roifman; G Wang
Phospholipase C-gamma 1 and phospholipase C-gamma 2 are substrates of the B cell antigen receptor associated protein tyrosine kinase.
Biochemical and biophysical research communications 1992;183(2):411-6.
1992: Chaim M Roifman; G X Wang; M Freedman; Z Q Pan
IL-7 receptor mediates tyrosine phosphorylation but does not activate the phosphatidylinositol-phospholipase C-gamma 1 pathway.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(4):1136-42.
1992: Rayfel Schneider; B A Lang; B J Reilly; Ronald M Laxer; Earl D Silverman; D Ibanez; C Bombardier; Chaim M Roifman
Prognostic indicators of joint destruction in systemic-onset juvenile rheumatoid arthritis.
The Journal of pediatrics 1992;120(2 Pt 1):200-5.
1991: I Melamed; Anne M Griffiths; Chaim M Roifman
Benefit of oral immune globulin therapy in patients with immunodeficiency and chronic diarrhea.
The Journal of pediatrics 1991;119(3):486-9.
1991: I Melamed; Gregory P Downey; K Aktories; Chaim M Roifman
Microfilament assembly is required for antigen-receptor-mediated activation of human B lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(4):1139-46.
1991: B A Lang; Ronald M Laxer; G Murphy; Earl D Silverman; Chaim M Roifman
Treatment of dermatomyositis with intravenous gammaglobulin.
The American journal of medicine 1991;91(2):169-72.
1991: A Cohen; T Grunberger; W Vanek; I D Dube; P J Doherty; Michelle Letarte; Chaim M Roifman; Melvin H Freedman
Constitutive expression and role in growth regulation of interleukin-1 and multiple cytokine receptors in a biphenotypic leukemic cell line.
Blood 1991;78(1):94-102.
1991: R Stein; D Hummel; D Bohn; H Levison; Chaim M Roifman
Lymphocytic pneumonitis following bone marrow transplantation in severe combined immunodeficiency.
The American review of respiratory disease 1991;143(6):1406-8.
1991: P J Doherty; Chaim M Roifman; S H Pan; Urszula Cymerman; S W Ho; E Thompson; Suzanne Kamel-Reid; A Cohen
Expression of the human T cell receptor V beta repertoire.
Molecular immunology 1991;28(6):607-12.
1991: I Melamed; Gregory P Downey; Chaim M Roifman
Tyrosine phosphorylation is essential for microfilament assembly in B lymphocytes.
Biochemical and biophysical research communications 1991;176(3):1424-9.
1991: Chaim M Roifman; K Chin; A Gazit; Gordon B Mills; C Gilon; A Levitzki
Tyrosine phosphorylation is an essential event in the stimulation of B lymphocytes by Staphylococcus aureus Cowan I.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(9):2965-71.
1991: P J Doherty; S Pan; J C Mulloy; E Thompson; P Thorner; J Barankiewiecz; Chaim M Roifman; A Cohen
Adenosine deaminase and thymocyte maturation.
Scandinavian journal of immunology 1991;33(4):405-10.
1991: I Melamed; S J Feanny; P M Sherman; Chaim M Roifman
Benefit of ketotifen in patients with eosinophilic gastroenteritis.
The American journal of medicine 1991;90(3):310-4.
1991: shai padeh; A Cohen; Chaim M Roifman
ATP-induced activation of human B lymphocytes via P2-purinoceptors.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(5):1626-32.
1991: shai padeh; A Levitzki; A Gazit; Gordon B Mills; Chaim M Roifman
Activation of phospholipase C in human B cells is dependent on tyrosine phosphorylation.
The Journal of clinical investigation 1991;87(3):1114-8.
1991: J Kevin Foskett; Chaim M Roifman; D Wong
Activation of calcium oscillations by thapsigargin in parotid acinar cells.
The Journal of biological chemistry 1991;266(5):2778-82.
1991: K Binkley; A Shore; R Buncic; Chaim M Roifman
Acquired Brown's syndrome associated with hypogammaglobulinemia.
The Journal of rheumatology 1991;18(1):139-41.
1991: L Bentur; Eric Nisbet-Brown; H Levison; Chaim M Roifman
Lung disease associated with IgG subclass deficiency in chronic mucocutaneous candidiasis.
The Journal of pediatrics 1991;118(1):82-6.
1990: L Bentur; I McKlusky; H Levison; Chaim M Roifman
Advanced lung disease in a patient with cystic fibrosis and hypogammaglobulinemia: response to intravenous immune globulin therapy.
The Journal of pediatrics 1990;117(5):741-3.
1990: Earl D Silverman; Ronald M Laxer; M Greenwald; Erwin W Gelfand; A Shore; Leonard Stein; Chaim M Roifman
Intravenous gamma globulin therapy in systemic juvenile rheumatoid arthritis.
Arthritis and rheumatism 1990;33(7):1015-22.
1990: L Bentur; N Shear; Chaim M Roifman
Cutaneous lymphohistiocytic infiltrates in patients with hypogammaglobulinemia.
The Journal of pediatrics 1990;116(1):68-72.
1990: Eli Shahar; E G Murphy; Chaim M Roifman
Benefit of intravenously administered immune serum globulin in patients with Guillain-Barré syndrome.
The Journal of pediatrics 1990;116(1):141-4.
1989: Chaim M Roifman; D Hummel; H Martinez-Valdez; P Thorner; P J Doherty; S Pan; F Cohen; A Cohen
Depletion of CD8+ cells in human thymic medulla results in selective immune deficiency.
The Journal of experimental medicine 1989;170(6):2177-82.
1989: Yedidia Bentur; D Hummel; Chaim M Roifman; Esther Giesbrecht; Gideon Koren
Interpretation of excessive levels of inhaled tobramycin.
Therapeutic drug monitoring 1989;11(1):109-10.
1988: Chaim M Roifman; Erwin W Gelfand
Replacement therapy with high dose intravenous gamma-globulin improves chronic sinopulmonary disease in patients with hypogammaglobulinemia.
The Pediatric infectious disease journal 1988;7(5 Suppl):S92-6.
1987: Chaim M Roifman; Gordon B Mills; D Stewart; Roy K Cheung; Sergio Grinstein; Erwin W Gelfand
Response of human B cells to different anti-immunoglobulin isotypes: absence of a correlation between early activation events and cell proliferation.
European journal of immunology 1987;17(12):1737-42.
1987: Z Estrov; Chaim M Roifman; G Mills; T Grunberger; E W Gelfand; Melvin H Freedman
The regulatory role of interleukin 2-responsive T lymphocytes on human marrow granulopoiesis.
Blood 1987;69(4):1161-6.
1986: Z Estrov; Chaim M Roifman; Y P Wang; T Grunberger; E W Gelfand; Melvin H Freedman
The regulatory role of interleukin 2-responsive T lymphocytes on early and mature erythroid progenitor proliferation.
Blood 1986;67(6):1607-10.
1985: Chaim M Roifman; Howard M Lederman; S Lavi; Leonard Stein; H Levison; Erwin W Gelfand
Benefit of intravenous IgG replacement in hypogammaglobulinemic patients with chronic sinopulmonary disease.
The American journal of medicine 1985;79(2):171-4.
1985: Chaim M Roifman; S Lavi; A T Moore; D J Morin; Leonard Stein; Erwin W Gelfand
Tenosynovitis of the superior oblique muscle (Brown syndrome) associated with juvenile rheumatoid arthritis.
The Journal of pediatrics 1985;106(4):617-9.