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Bernard Roizman

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Minfeng Shu; Brunella Taddeo; Weiran Zhang; Bernard Roizman
Selective degradation of mRNAs by the HSV host shutoff RNase is regulated by the UL47 tegument protein.
Brunella Taddeo; Weiran Zhang; Bernard Roizman
The herpes simplex virus host shutoff RNase degrades cellular and viral mRNAs made before infection but not viral mRNA made after infection.
Maria Teresa Sciortino; Gabriel Siracusano; Brunella Taddeo; Antonio Mastino; Tiziana Parisi; Bernard Roizman
The virion host shutoff RNase plays a key role in blocking the activation of protein kinase R in cells infected with herpes simplex virus 1.

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All Publications

2013: Minfeng Shu; Brunella Taddeo; Weiran Zhang; Bernard Roizman
Selective degradation of mRNAs by the HSV host shutoff RNase is regulated by the UL47 tegument protein.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(18):E1669-75.
2013: Brunella Taddeo; Weiran Zhang; Bernard Roizman
The herpes simplex virus host shutoff RNase degrades cellular and viral mRNAs made before infection but not viral mRNA made after infection.
Journal of virology 2013;87(8):4516-22.
2013: Maria Teresa Sciortino; Gabriel Siracusano; Brunella Taddeo; Antonio Mastino; Tiziana Parisi; Bernard Roizman
The virion host shutoff RNase plays a key role in blocking the activation of protein kinase R in cells infected with herpes simplex virus 1.
Journal of virology 2013;87(6):3271-6.
2013: Guoying Zhou; Te Du; Bernard Roizman
HSV carrying WT REST establishes latency but reactivates only if the synthesis of REST is suppressed.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(6):E498-506.
2013: Guoying Zhou; Te Du; Bernard Roizman
The Role of the CoREST/REST Repressor Complex in Herpes Simplex Virus 1 Productive Infection and in Latency.
Viruses 2013;5(5):1208-18.
2012: Stephen Mallon; Bassam T Wakim; Bernard Roizman
Use of biotinylated plasmid DNA as a surrogate for HSV DNA to identify proteins that repress or activate viral gene expression.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(51):E3549-57.
2012: Maria Kalamvoki; Haidong Gu; Bernard Roizman
Overexpression of the ubiquitin-specific protease 7 resulting from transfection or mutations in the ICP0 binding site accelerates rather than depresses herpes simplex virus 1 gene expression.
Journal of virology 2012;86(23):12871-8.
2012: Te Du; Guoying Zhou; Bernard Roizman
Induction of apoptosis accelerates reactivation of latent HSV-1 in ganglionic organ cultures and replication in cell cultures.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(36):14616-21.
2012: Nikolai N Khodarev; Bernard Roizman; Ralph R Weichselbaum
Molecular pathways: interferon/stat1 pathway: role in the tumor resistance to genotoxic stress and aggressive growth.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(11):3015-21.
2011: Te Du; Guoying Zhou; Bernard Roizman
HSV-1 gene expression from reactivated ganglia is disordered and concurrent with suppression of latency-associated transcript and miRNAs.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(46):18820-4.
2011: Maria Kalamvoki; Bernard Roizman
The histone acetyltransferase CLOCK is an essential component of the herpes simplex virus 1 transcriptome that includes TFIID, ICP4, ICP27, and ICP22.
Journal of virology 2011;85(18):9472-7.
2011: Xiaojia Wang; Caroline Patenode; Bernard Roizman
US3 protein kinase of HSV-1 cycles between the cytoplasm and nucleus and interacts with programmed cell death protein 4 (PDCD4) to block apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(35):14632-6.
2011: Bernard Roizman
The checkpoints of viral gene expression in productive and latent infection: the role of the HDAC/CoREST/LSD1/REST repressor complex.
Journal of virology 2011;85(15):7474-82.
2011: Guoying Zhou; Du Te; Bernard Roizman
The CoREST/REST repressor is both necessary and inimical for expression of herpes simplex virus genes.
mBio 2011;2(1):e00313-10.
2010: Maria Kalamvoki; Bernard Roizman
Circadian CLOCK histone acetyl transferase localizes at ND10 nuclear bodies and enables herpes simplex virus gene expression.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(41):17721-6.
2010: Maria Kalamvoki; Bernard Roizman
Interwoven roles of cyclin D3 and cdk4 recruited by ICP0 and ICP4 in the expression of herpes simplex virus genes.
Journal of virology 2010;84(19):9709-17.
2010: Brunella Taddeo; Weiran Zhang; Bernard Roizman
Role of herpes simplex virus ICP27 in the degradation of mRNA by virion host shutoff RNase.
Journal of virology 2010;84(19):10182-90.
2010: Te Du; Guoying Zhou; Shaniya Khan; Haidong Gu; Bernard Roizman
Disruption of HDAC/CoREST/REST repressor by dnREST reduces genome silencing and increases virulence of herpes simplex virus.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(36):15904-9.
2010: Maria Kalamvoki; Bernard Roizman
Role of herpes simplex virus ICP0 in the transactivation of genes introduced by infection or transfection: a reappraisal.
Journal of virology 2010;84(9):4222-8.
2010: Vladimir Jovasevic; Bernard Roizman
The novel HSV-1 US5-1 RNA is transcribed off a domain encoding US5, US4, US3, US2 and alpha22.
Virology journal 2010;7():103.
2009: Haidong Gu; Alice P W Poon; Bernard Roizman
During its nuclear phase the multifunctional regulatory protein ICP0 undergoes proteolytic cleavage characteristic of polyproteins.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(45):19132-7.
2009: Maria Kalamvoki; Bernard Roizman
ICP0 enables and monitors the function of D cyclins in herpes simplex virus 1 infected cells.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(34):14576-80.
2009: Brunella Taddeo; Weiran Zhang; Bernard Roizman
The virion-packaged endoribonuclease of herpes simplex virus 1 cleaves mRNA in polyribosomes.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(29):12139-44.
2009: Elena V Efimova; Hua Liang; Sean P Pitroda; Edwardine Labay; Thomas E Darga; Vera Levina; Anna Lokshin; Bernard Roizman; Ralph R Weichselbaum; Nikolai N Khodarev
Radioresistance of Stat1 over-expressing tumour cells is associated with suppressed apoptotic response to cytotoxic agents and increased IL6-IL8 signalling.
International journal of radiation biology 2009;85(5):421-31.
2009: Haidong Gu; Bernard Roizman
Engagement of the lysine-specific demethylase/HDAC1/CoREST/REST complex by herpes simplex virus 1.
Journal of virology 2009;83(9):4376-85.
2009: Andrew J Davison; Richard Eberle; Bernhard Ehlers; Gary S Hayward; Duncan J McGeoch; Anthony C Minson; Philip E Pellett; Bernard Roizman; Michael J Studdert; Etienne Thiry
The order Herpesvirales.
Archives of virology 2009;154(1):171-7.
2009: Haidong Gu; Bernard Roizman
The two functions of herpes simplex virus 1 ICP0, inhibition of silencing by the CoREST/REST/HDAC complex and degradation of PML, are executed in tandem.
Journal of virology 2009;83(1):181-7.
2008: Ralph R Weichselbaum; Hemant Ishwaran; Taewon Yoon; Dimitry S A Nuyten; Samuel W Baker; Nikolai N Khodarev; Andy W Su; Arif Y Shaikh; Paul Roach; Bas Kreike; Bernard Roizman; Jonas Bergh; Yudi Pawitan; Marc J van de Vijver; Andy J Minn
An interferon-related gene signature for DNA damage resistance is a predictive marker for chemotherapy and radiation for breast cancer.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(47):18490-5.
2008: Lizette Olga Durand; Bernard Roizman
Role of cdk9 in the optimization of expression of the genes regulated by ICP22 of herpes simplex virus 1.
Journal of virology 2008;82(21):10591-9.
2008: Li Liang; Bernard Roizman
Expression of gamma interferon-dependent genes is blocked independently by virion host shutoff RNase and by US3 protein kinase.
Journal of virology 2008;82(10):4688-96.
2008: Benjamin A Smith-Donald; Lizette O Durand; Bernard Roizman
Role of cellular phosphatase cdc25C in herpes simplex virus 1 replication.
Journal of virology 2008;82(9):4527-32.
2008: Benjamin A Smith-Donald; Bernard Roizman
The interaction of herpes simplex virus 1 regulatory protein ICP22 with the cdc25C phosphatase is enabled in vitro by viral protein kinases US3 and UL13.
Journal of virology 2008;82(9):4533-43.
2008: Vladimir Jovasevic; Li Liang; Bernard Roizman
Proteolytic cleavage of VP1-2 is required for release of herpes simplex virus 1 DNA into the nucleus.
Journal of virology 2008;82(7):3311-9.
2008: Maria Kalamvoki; Jianguo Qu; Bernard Roizman
Translocation and colocalization of ICP4 and ICP0 in cells infected with herpes simplex virus 1 mutants lacking glycoprotein E, glycoprotein I, or the virion host shutoff product of the UL41 gene.
Journal of virology 2008;82(4):1701-13.
2008: Kui Yang; Alice P W Poon; Bernard Roizman; Joel D Baines
Temperature-sensitive mutations in the putative herpes simplex virus type 1 terminase subunits pUL15 and pUL33 preclude viral DNA cleavage/packaging and interaction with pUL28 at the nonpermissive temperature.
Journal of virology 2008;82(1):487-94.
2007: Haidong Gu; Bernard Roizman
Herpes simplex virus-infected cell protein 0 blocks the silencing of viral DNA by dissociating histone deacetylases from the CoREST-REST complex.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(43):17134-9.
2007: Nikolai N Khodarev; Andy J Minn; Elena V Efimova; Thomas E Darga; Edwardine Labay; Michael A Beckett; Helena J Mauceri; Bernard Roizman; Ralph R Weichselbaum
Signal transducer and activator of transcription 1 regulates both cytotoxic and prosurvival functions in tumor cells.
Cancer research 2007;67(19):9214-20.
2007: Maria Teresa Sciortino; Brunella Taddeo; Maria Giuffrè-Cuculletto; Maria Antonietta Medici; Antonio Mastino; Bernard Roizman
Replication-competent herpes simplex virus 1 isolates selected from cells transfected with a bacterial artificial chromosome DNA lacking only the UL49 gene vary with respect to the defect in the UL41 gene encoding host shutoff RNase.
Journal of virology 2007;81(20):10924-32.
2007: Luca Benetti; Bernard Roizman
In transduced cells, the US3 protein kinase of herpes simplex virus 1 precludes activation and induction of apoptosis by transfected procaspase 3.
Journal of virology 2007;81(19):10242-8.
2007: Jula Veerapong; Kai Bickenbach; Michael Y Shao; Kerrington D Smith; Mitchell C Posner; Bernard Roizman; Ralph R Weichselbaum
Systemic delivery of (gamma1)34.5-deleted herpes simplex virus-1 selectively targets and treats distant human xenograft tumors that express high MEK activity.
Cancer research 2007;67(17):8301-6.
2007: Christopher L Skelly; Amito Chandiwal; James E Vosicky; Ralph R Weichselbaum; Bernard Roizman
Attenuated herpes simplex virus 1 blocks arterial apoptosis and intimal hyperplasia induced by balloon angioplasty and reduced blood flow.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(30):12474-8.
2007: Brunella Taddeo; Maria Teresa Sciortino; Weiran Zhang; Bernard Roizman
Interaction of herpes simplex virus RNase with VP16 and VP22 is required for the accumulation of the protein but not for accumulation of mRNA.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(29):12163-8.
2007: Maria Kalamvoki; Bernard Roizman
Bcl-2 blocks accretion or depletion of stored calcium but has no effect on the redistribution of IP3 receptor I mediated by glycoprotein E of herpes simplex virus 1.
Journal of virology 2007;81(12):6316-25.
2007: Guoying Zhou; Bernard Roizman
Separation of receptor-binding and profusogenic domains of glycoprotein D of herpes simplex virus 1 into distinct interacting proteins.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(10):4142-6.
2007: Alice P W Poon; Bernard Roizman
Mapping of key functions of the herpes simplex virus 1 U(S)3 protein kinase: the U(S)3 protein can form functional heteromultimeric structures derived from overlapping truncated polypeptides.
Journal of virology 2007;81(4):1980-9.
2007: Ilkka Kari; Stina Syrjänen; Bo Johansson; Piritta Peri; Bin He; Bernard Roizman; Veijo Hukkanen
Antisense RNA directed to the human papillomavirus type 16 E7 mRNA from herpes simplex virus type 1 derived vectors is expressed in CaSki cells and downregulates E7 mRNA.
Virology journal 2007;4():47.
2007: Joel D Baines; Elizabeth Wills; Robert Jacob; Janice Pennington; Bernard Roizman
Glycoprotein M of herpes simplex virus 1 is incorporated into virions during budding at the inner nuclear membrane.
Journal of virology 2007;81(2):800-12.
2006: Sunil J Advani; James Mezhir; Bernard Roizman; Ralph R Weichselbaum
ReVOLT: radiation-enhanced viral oncolytic therapy.
International journal of radiation oncology, biology, physics 2006;66(3):637-46.
2006: Brunella Taddeo; Bernard Roizman
The virion host shutoff protein (UL41) of herpes simplex virus 1 is an endoribonuclease with a substrate specificity similar to that of RNase A.
Journal of virology 2006;80(18):9341-5.
2006: Li Liang; Bernard Roizman
Herpes simplex virus 1 precludes replenishment of the short-lived receptor of tumor necrosis factor alpha by virion host shutoff-dependent degradation of its mRNA.
Journal of virology 2006;80(15):7756-9.
2006: Gabriella Campadelli-Fiume; Bernard Roizman
The egress of herpesviruses from cells: the unanswered questions.
Journal of virology 2006;80(13):6716-7; author replies 6717-9.
2006: Alice P W Poon; Haidong Gu; Bernard Roizman
ICP0 and the US3 protein kinase of herpes simplex virus 1 independently block histone deacetylation to enable gene expression.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(26):9993-8.
2006: Guoying Zhou; Bernard Roizman
Construction and properties of a herpes simplex virus 1 designed to enter cells solely via the IL-13alpha2 receptor.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(14):5508-13.
2006: Alice P W Poon; Luca Benetti; Bernard Roizman
U(S)3 and U(S)3.5 protein kinases of herpes simplex virus 1 differ with respect to their functions in blocking apoptosis and in virion maturation and egress.
Journal of virology 2006;80(8):3752-64.
2006: Yu Liang; Bernard Roizman
State and role of SRC family kinases in replication of herpes simplex virus 1.
Journal of virology 2006;80(7):3349-59.
2006: Luca Benetti; Bernard Roizman
Protein kinase B/Akt is present in activated form throughout the entire replicative cycle of deltaU(S)3 mutant virus but only at early times after infection with wild-type herpes simplex virus 1.
Journal of virology 2006;80(7):3341-8.
2006: H Kamiyama; Guoying Zhou; Bernard Roizman
Herpes simplex virus 1 recombinant virions exhibiting the amino terminal fragment of urokinase-type plasminogen activator can enter cells via the cognate receptor.
Gene therapy 2006;13(7):621-9.
2006: Brunella Taddeo; Weiran Zhang; Bernard Roizman
The U(L)41 protein of herpes simplex virus 1 degrades RNA by endonucleolytic cleavage in absence of other cellular or viral proteins.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(8):2827-32.
2006: Kerrington D Smith; James Mezhir; Kai Bickenbach; Jula Veerapong; Jean Charron; Mitchell C Posner; Bernard Roizman; Ralph R Weichselbaum
Activated MEK suppresses activation of PKR and enables efficient replication and in vivo oncolysis by Deltagamma(1)34.5 mutants of herpes simplex virus 1.
Journal of virology 2006;80(3):1110-20.
2005: James Mezhir; Sunil J Advani; Kerrington D Smith; Thomas E Darga; Alice P W Poon; Hank Schmidt; Mitchell C Posner; Bernard Roizman; Ralph R Weichselbaum
Ionizing radiation activates late herpes simplex virus 1 promoters via the p38 pathway in tumors treated with oncolytic viruses.
Cancer research 2005;65(20):9479-84.
2005: Bernard Roizman; Haidong Gu; Gail Mandel
The first 30 minutes in the life of a virus: unREST in the nucleus.
Cell cycle (Georgetown, Tex.) 2005;4(8):1019-21.
2005: Elizabeth K Hellums; James M Markert; Jacqueline N Parker; Bin He; Bernard Perbal; Bernard Roizman; Richard J Whitley; Catherine P Langford; Suman Bharara; G Yancey Gillespie
Increased efficacy of an interleukin-12-secreting herpes simplex virus in a syngeneic intracranial murine glioma model.
Neuro-oncology 2005;7(3):213-24.
2005: Alice P W Poon; Bernard Roizman
Herpes simplex virus 1 ICP22 regulates the accumulation of a shorter mRNA and of a truncated US3 protein kinase that exhibits altered functions.
Journal of virology 2005;79(13):8470-9.
2005: Lizette O Durand; Sunil J Advani; Alice P W Poon; Bernard Roizman
The carboxyl-terminal domain of RNA polymerase II is phosphorylated by a complex containing cdk9 and infected-cell protein 22 of herpes simplex virus 1.
Journal of virology 2005;79(11):6757-62.
2005: Haidong Gu; Yu Liang; Gail Mandel; Bernard Roizman
Components of the REST/CoREST/histone deacetylase repressor complex are disrupted, modified, and translocated in HSV-1-infected cells.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(21):7571-6.
2005: Guoying Zhou; Bernard Roizman
Characterization of a recombinant herpes simplex virus 1 designed to enter cells via the IL13Ralpha2 receptor of malignant glioma cells.
Journal of virology 2005;79(9):5272-7.
2005: Yu Liang; Alexei Kurakin; Bernard Roizman
Herpes simplex virus 1 infected cell protein 0 forms a complex with CIN85 and Cbl and mediates the degradation of EGF receptor from cell surfaces.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(16):5838-43.
2005: Zachary K Baldwin; Amito Chandiwal; Viji Balasubramanian; Benjamin J Pearce; Michael A Curi; Christopher L Skelly; Wendy W Huang; James E Vosicky; Bernard Roizman; Ralph R Weichselbaum; Lewis B Schwartz
Modulation of vascular remodeling induced by a brief intraluminal exposure to the recombinant R7020 strain of Herpes simplex-1.
Journal of vascular surgery 2005;41(1):115-21.
2004: Audrey Esclatine; Brunella Taddeo; Bernard Roizman
The UL41 protein of herpes simplex virus mediates selective stabilization or degradation of cellular mRNAs.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(52):18165-70.
2004: Joseph S Pagano; Martin Blaser; Marie Annick Buendia; Blossom Damania; Kamel Khalili; Nancy Raab-Traub; Bernard Roizman
Infectious agents and cancer: criteria for a causal relation.
Seminars in cancer biology 2004;14(6):453-71.
2004: Brunella Taddeo; Audrey Esclatine; Bernard Roizman
Post-transcriptional processing of cellular RNAs in herpes simplex virus-infected cells.
Biochemical Society transactions 2004;32(Pt 5):697-701.
2004: Brunella Taddeo; Weiran Zhang; Fred Lakeman; Bernard Roizman
Cells lacking NF-kappaB or in which NF-kappaB is not activated vary with respect to ability to sustain herpes simplex virus 1 replication and are not susceptible to apoptosis induced by a replication-incompetent mutant virus.
Journal of virology 2004;78(21):11615-21.
2004: Audrey Esclatine; Brunella Taddeo; Bernard Roizman
Herpes simplex virus 1 induces cytoplasmic accumulation of TIA-1/TIAR and both synthesis and cytoplasmic accumulation of tristetraprolin, two cellular proteins that bind and destabilize AU-rich RNAs.
Journal of virology 2004;78(16):8582-92.
2004: Luca Benetti; Bernard Roizman
Herpes simplex virus protein kinase US3 activates and functionally overlaps protein kinase A to block apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(25):9411-6.
2004: Ana Virginia Chee; Bernard Roizman
Herpes simplex virus 1 gene products occlude the interferon signaling pathway at multiple sites.
Journal of virology 2004;78(8):4185-96.
2004: Audrey Esclatine; Brunella Taddeo; Linton Evans; Bernard Roizman
The herpes simplex virus 1 UL41 gene-dependent destabilization of cellular RNAs is selective and may be sequence-specific.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(10):3603-8.
2004: Ryan Hagglund; Bernard Roizman
Role of ICP0 in the strategy of conquest of the host cell by herpes simplex virus 1.
Journal of virology 2004;78(5):2169-78.
2004: Nikolai N Khodarev; Michael A Beckett; Edwardine Labay; Thomas E Darga; Bernard Roizman; Ralph R Weichselbaum
STAT1 is overexpressed in tumors selected for radioresistance and confers protection from radiation in transduced sensitive cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(6):1714-9.
2003: Ryan Hagglund; Bernard Roizman
Herpes simplex virus 1 mutant in which the ICP0 HUL-1 E3 ubiquitin ligase site is disrupted stabilizes cdc34 but degrades D-type cyclins and exhibits diminished neurotoxicity.
Journal of virology 2003;77(24):13194-202.
2003: Alice P W Poon; Yu Liang; Bernard Roizman
Herpes simplex virus 1 gene expression is accelerated by inhibitors of histone deacetylases in rabbit skin cells infected with a mutant carrying a cDNA copy of the infected-cell protein no. 0.
Journal of virology 2003;77(23):12671-8.
2003: Sunil J Advani; Lizette O Durand; Ralph R Weichselbaum; Bernard Roizman
Oct-1 is posttranslationally modified and exhibits reduced capacity to bind cognate sites at late times after infection with herpes simplex virus 1.
Journal of virology 2003;77(22):11927-32.
2003: Brunella Taddeo; Ting Rong Luo; Weiran Zhang; Bernard Roizman
Activation of NF-kappaB in cells productively infected with HSV-1 depends on activated protein kinase R and plays no apparent role in blocking apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(21):12408-13.
2003: Haidong Gu; Bernard Roizman
The degradation of promyelocytic leukemia and Sp100 proteins by herpes simplex virus 1 is mediated by the ubiquitin-conjugating enzyme UbcH5a.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(15):8963-8.
2003: Ana Virginia Chee; Pascal LOPEZ; Pier Paolo Pandolfi; Bernard Roizman
Promyelocytic leukemia protein mediates interferon-based anti-herpes simplex virus 1 effects.
Journal of virology 2003;77(12):7101-5.
2003: Michael A Curi; Christopher L Skelly; Shari L Meyerson; Zachary K Baldwin; Viji Balasubramanian; Sunil J Advani; Seymour Glagov; Bernard Roizman; Ralph R Weichselbaum; Lewis B Schwartz
Sustained inhibition of experimental neointimal hyperplasia with a genetically modified herpes simplex virus.
Journal of vascular surgery 2003;37(6):1294-300.
2003: Luca Benetti; Joshua C. Munger; Bernard Roizman
The herpes simplex virus 1 US3 protein kinase blocks caspase-dependent double cleavage and activation of the proapoptotic protein BAD.
Journal of virology 2003;77(11):6567-73.
2003: Brunella Taddeo; Audrey Esclatine; Weiran Zhang; Bernard Roizman
The stress-inducible immediate-early responsive gene IEX-1 is activated in cells infected with herpes simplex virus 1, but several viral mechanisms, including 3' degradation of its RNA, preclude expression of the gene.
Journal of virology 2003;77(11):6178-87.
2003: Sunil J Advani; Ralph R Weichselbaum; Bernard Roizman
Herpes simplex virus 1 activates cdc2 to recruit topoisomerase II alpha for post-DNA synthesis expression of late genes.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(8):4825-30.
2003: Guoying Zhou; Elisa Avitabile; Gabriella Campadelli-Fiume; Bernard Roizman
The domains of glycoprotein D required to block apoptosis induced by herpes simplex virus 1 are largely distinct from those involved in cell-cell fusion and binding to nectin1.
Journal of virology 2003;77(6):3759-67.
2003: Nikolai N Khodarev; James Park; Yasushi Kataoka; Edwardine Nodzenski; Samuel Hellman; Bernard Roizman; Ralph R Weichselbaum; Charles A Pelizzari
Receiver operating characteristic analysis: a general tool for DNA array data filtration and performance estimation.
Genomics 2003;81(2):202-9.
2003: Joshua C. Munger; Ryan Hagglund; Bernard Roizman
Infected cell protein No. 22 is subject to proteolytic cleavage by caspases activated by a mutant that induces apoptosis.
Virology 2003;305(2):364-70.
2002: Brunella Taddeo; Audrey Esclatine; Bernard Roizman
The patterns of accumulation of cellular RNAs in cells infected with a wild-type and a mutant herpes simplex virus 1 lacking the virion host shutoff gene.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(26):17031-6.
2002: Guoying Zhou; Guo-Jie Ye; Waldemar Debinski; Bernard Roizman
Engineered herpes simplex virus 1 is dependent on IL13Ralpha 2 receptor for cell entry and independent of glycoprotein D receptor interaction.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(23):15124-9.
2002: Guoying Zhou; Bernard Roizman
Truncated forms of glycoprotein D of herpes simplex virus 1 capable of blocking apoptosis and of low-efficiency entry into cells form a heterodimer dependent on the presence of a cysteine located in the shared transmembrane domains.
Journal of virology 2002;76(22):11469-75.
2002: Alice P W Poon; Saul J Silverstein; Bernard Roizman
An early regulatory function required in a cell type-dependent manner is expressed by the genomic but not the cDNA copy of the herpes simplex virus 1 gene encoding infected cell protein 0.
Journal of virology 2002;76(19):9744-55.
2002: Sunil J Advani; Ralph R Weichselbaum; Richard J Whitley; Bernard Roizman
Friendly fire: redirecting herpes simplex virus-1 for therapeutic applications.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2002;8(9):551-63.
2002: Pascal LOPEZ; Robert Jacob; Bernard Roizman
Overexpression of promyelocytic leukemia protein precludes the dispersal of ND10 structures and has no effect on accumulation of infectious herpes simplex virus 1 or its proteins.
Journal of virology 2002;76(18):9355-67.
2002: Richard J Whitley; Bernard Roizman
Herpes simplex viruses: is a vaccine tenable?
The Journal of clinical investigation 2002;110(2):145-51.
2002: Joanne Trgovcich; David C Johnson; Bernard Roizman
Cell surface major histocompatibility complex class II proteins are regulated by the products of the gamma(1)34.5 and U(L)41 genes of herpes simplex virus 1.
Journal of virology 2002;76(14):6974-86.
2002: Maria Teresa Sciortino; Brunella Taddeo; Alice P W Poon; Antonio Mastino; Bernard Roizman
Of the three tegument proteins that package mRNA in herpes simplex virions, one (VP22) transports the mRNA to uninfected cells for expression prior to viral infection.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(12):8318-23.
2002: Ryan Hagglund; Bernard Roizman
Characterization of the novel E3 ubiquitin ligase encoded in exon 3 of herpes simplex virus-1-infected cell protein 0.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(12):7889-94.
2002: Guoying Zhou; Bernard Roizman
Cation-independent mannose 6-phosphate receptor blocks apoptosis induced by herpes simplex virus 1 mutants lacking glycoprotein D and is likely the target of antiapoptotic activity of the glycoprotein.
Journal of virology 2002;76(12):6197-204.
2002: Kevin A Cassady; Martin Gross; G Yancey Gillespie; Bernard Roizman
Second-site mutation outside of the U(S)10-12 domain of Deltagamma(1)34.5 herpes simplex virus 1 recombinant blocks the shutoff of protein synthesis induced by activated protein kinase R and partially restores neurovirulence.
Journal of virology 2002;76(3):942-9.
2002: Ryan Hagglund; Charles Van Sant; Pascal LOPEZ; Bernard Roizman
Herpes simplex virus 1-infected cell protein 0 contains two E3 ubiquitin ligase sites specific for different E2 ubiquitin-conjugating enzymes.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(2):631-6.
2002: SM Chung; Sunil J Advani; J D Bradley; Y Kataoka; K Vashistha; S Y Yan; JM Markert; G Yancey Gillespie; Richard J Whitley; Bernard Roizman; Ralph R Weichselbaum
The use of a genetically engineered herpes simplex virus (R7020) with ionizing radiation for experimental hepatoma.
Gene therapy 2002;9(1):75-80.
2002: Ryan Hagglund; Joshua C. Munger; Alice P W Poon; Bernard Roizman
U(S)3 protein kinase of herpes simplex virus 1 blocks caspase 3 activation induced by the products of U(S)1.5 and U(L)13 genes and modulates expression of transduced U(S)1.5 open reading frame in a cell type-specific manner.
Journal of virology 2002;76(2):743-54.
2001: Christopher L Skelly; Michael A Curi; Shari L Meyerson; David H Woo; DM Hari; James E Vosicky; Sunil J Advani; Helena J Mauceri; Seymour Glagov; Bernard Roizman; Ralph R Weichselbaum; Lewis B Schwartz
Prevention of restenosis by a herpes simplex virus mutant capable of controlled long-term expression in vascular tissue in vivo.
Gene therapy 2001;8(24):1840-6.
2001: Sunil J Advani; Ralph R Weichselbaum; Bernard Roizman
cdc2 cyclin-dependent kinase binds and phosphorylates herpes simplex virus 1 U(L)42 DNA synthesis processivity factor.
Journal of virology 2001;75(21):10326-33.
2001: Nikolai N Khodarev; James Park; Jianqing Yu; Nalin Gupta; Edwardine Nodzenski; Bernard Roizman; Ralph R Weichselbaum
Dose-dependent and independent temporal patterns of gene responses to ionizing radiation in normal and tumor cells and tumor xenografts.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(22):12665-70.
2001: Maria Teresa Sciortino; M Suzuki; Brunella Taddeo; Bernard Roizman
RNAs extracted from herpes simplex virus 1 virions: apparent selectivity of viral but not cellular RNAs packaged in virions.
Journal of virology 2001;75(17):8105-16.
2001: Sunil J Advani; Ryan Hagglund; Ralph R Weichselbaum; Bernard Roizman
Posttranslational processing of infected cell proteins 0 and 4 of herpes simplex virus 1 is sequential and reflects the subcellular compartment in which the proteins localize.
Journal of virology 2001;75(17):7904-12.
2001: Joshua C. Munger; Bernard Roizman
The US3 protein kinase of herpes simplex virus 1 mediates the posttranslational modification of BAD and prevents BAD-induced programmed cell death in the absence of other viral proteins.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(18):10410-5.
2001: Charles Van Sant; Ryan Hagglund; Pascal LOPEZ; Bernard Roizman
The infected cell protein 0 of herpes simplex virus 1 dynamically interacts with proteasomes, binds and activates the cdc34 E2 ubiquitin-conjugating enzyme, and possesses in vitro E3 ubiquitin ligase activity.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(15):8815-20.
2001: Guoying Zhou; Bernard Roizman
The domains of glycoprotein D required to block apoptosis depend on whether glycoprotein D is present in the virions carrying herpes simplex virus 1 genome lacking the gene encoding the glycoprotein.
Journal of virology 2001;75(13):6166-72.
2001: Joshua C. Munger; Ana Virginia Chee; Bernard Roizman
The U(S)3 protein kinase blocks apoptosis induced by the d120 mutant of herpes simplex virus 1 at a premitochondrial stage.
Journal of virology 2001;75(12):5491-7.
2001: Richard J Whitley; Bernard Roizman
Herpes simplex virus infections.
Lancet 2001;357(9267):1513-8.
2001: Eeva K Broberg; Niko Setälä; Matias Röyttä; Aimo A Salmi; Juha-Pekka Erälinna; Bin He; Bernard Roizman; Veijo Hukkanen
Expression of interleukin-4 but not of interleukin-10 from a replicative herpes simplex virus type 1 viral vector precludes experimental allergic encephalomyelitis.
Gene therapy 2001;8(10):769-77.
2001: Pascal LOPEZ; Charles Van Sant; Bernard Roizman
Requirements for the nuclear-cytoplasmic translocation of infected-cell protein 0 of herpes simplex virus 1.
Journal of virology 2001;75(8):3832-40.
2001: Bernard Roizman; Richard J Whitley
The nine ages of herpes simplex virus.
Herpes : the journal of the IHMF 2001;8(1):23-7.
2001: Charles Van Sant; Pascal LOPEZ; Sunil J Advani; Bernard Roizman
Role of cyclin D3 in the biology of herpes simplex virus 1 ICPO.
Journal of virology 2001;75(4):1888-98.
2001: Ralph R Weichselbaum; Donald Kufe; Sunil J Advani; Bernard Roizman
Molecular targeting of gene therapy and radiotherapy.
Acta oncologica (Stockholm, Sweden) 2001;40(6):735-8.
2000: Guoying Zhou; Veronica Galvan; Gabriella Campadelli-Fiume; Bernard Roizman
Glycoprotein D or J delivered in trans blocks apoptosis in SK-N-SH cells induced by a herpes simplex virus 1 mutant lacking intact genes expressing both glycoproteins.
Journal of virology 2000;74(24):11782-91.
2000: Alice P W Poon; WO Ogle; Bernard Roizman
Posttranslational processing of infected cell protein 22 mediated by viral protein kinases is sensitive to amino acid substitutions at distant sites and can be cell-type specific.
Journal of virology 2000;74(23):11210-4.
2000: Guoying Zhou; Bernard Roizman
Wild-type herpes simplex virus 1 blocks programmed cell death and release of cytochrome c but not the translocation of mitochondrial apoptosis-inducing factor to the nuclei of human embryonic lung fibroblasts.
Journal of virology 2000;74(19):9048-53.
2000: Glenn Randall; Michael Lagunoff; Bernard Roizman
Herpes simplex virus 1 open reading frames O and P are not necessary for establishment of latent infection in mice.
Journal of virology 2000;74(19):9019-27.
2000: Guo-Jie Ye; Bernard Roizman
The essential protein encoded by the UL31 gene of herpes simplex virus 1 depends for its stability on the presence of UL34 protein.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(20):11002-7.
2000: Sunil J Advani; Ralph R Weichselbaum; Bernard Roizman
The role of cdc2 in the expression of herpes simplex virus genes.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(20):10996-1001.
2000: Sunil J Advani; Ralph R Weichselbaum; Bernard Roizman
E2F proteins are posttranslationally modified concomitantly with a reduction in nuclear binding activity in cells infected with herpes simplex virus 1.
Journal of virology 2000;74(17):7842-50.
2000: Bernard Roizman
Redefining virology.
Science (New York, N.Y.) 2000;288(5475):2327-8.
2000: Veronica Galvan; R Brandimarti; Joshua C. Munger; Bernard Roizman
Bcl-2 blocks a caspase-dependent pathway of apoptosis activated by herpes simplex virus 1 infection in HEp-2 cells.
Journal of virology 2000;74(4):1931-8.
2000: Guo-Jie Ye; Kevin T Vaughan; Richard B Vallee; Bernard Roizman
The herpes simplex virus 1 U(L)34 protein interacts with a cytoplasmic dynein intermediate chain and targets nuclear membrane.
Journal of virology 2000;74(3):1355-63.
2000: PL Ward; Brunella Taddeo; NS Markovitz; Bernard Roizman
Identification of a novel expressed open reading frame situated between genes U(L)20 and U(L)21 of the herpes simplex virus 1 genome.
Virology 2000;266(2):275-85.
2000: NS Markovitz; Bernard Roizman
Replication-competent herpes simplex viral vectors for cancer therapy.
Advances in virus research 2000;55():409-24.
2000: James M Markert; G Yancey Gillespie; R R Weichselbaum; Bernard Roizman; Richard J Whitley
Genetically engineered HSV in the treatment of glioma: a review.
Reviews in medical virology 2000;10(1):17-30.
2000: NS Markovitz; Bernard Roizman
Small dense nuclear bodies are the site of localization of herpes simplex virus 1 U(L)3 and U(L)4 proteins and of ICP22 only when the latter protein is present.
Journal of virology 2000;74(1):523-8.
2000: Sunil J Advani; R Brandimarti; Ralph R Weichselbaum; Bernard Roizman
The disappearance of cyclins A and B and the increase in activity of the G(2)/M-phase cellular kinase cdc2 in herpes simplex virus 1-infected cells require expression of the alpha22/U(S)1.5 and U(L)13 viral genes.
Journal of virology 2000;74(1):8-15.
1999: Nikolai N Khodarev; Sunil J Advani; Nalin Gupta; Bernard Roizman; Ralph R Weichselbaum
Accumulation of specific RNAs encoding transcriptional factors and stress response proteins against a background of severe depletion of cellular RNAs in cells infected with herpes simplex virus 1.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(21):12062-7.
1999: NS Markovitz; F Filatov; Bernard Roizman
The U(L)3 protein of herpes simplex virus 1 is translated predominantly from the second in-frame methionine codon and is subject to at least two posttranslational modifications.
Journal of virology 1999;73(10):8010-8.
1999: Charles Van Sant; Y Kawaguchi; Bernard Roizman
A single amino acid substitution in the cyclin D binding domain of the infected cell protein no. 0 abrogates the neuroinvasiveness of herpes simplex virus without affecting its ability to replicate.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):8184-9.
1999: L McCormick; K Igarashi; Bernard Roizman
Posttranscriptional regulation of US11 in cells infected with a herpes simplex virus 1 recombinant lacking both 222-bp domains containing S-component origins of DNA synthesis.
Virology 1999;259(2):286-98.
1999: J D Bradley; Y Kataoka; S Advani; SM Chung; Ramin B Arani; G Yancey Gillespie; Richard J Whitley; JM Markert; Bernard Roizman; Ralph R Weichselbaum
Ionizing radiation improves survival in mice bearing intracranial high-grade gliomas injected with genetically modified herpes simplex virus.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(6):1517-22.
1999: S Jahedi; NS Markovitz; F Filatov; Bernard Roizman
Colocalization of the herpes simplex virus 1 UL4 protein with infected cell protein 22 in small, dense nuclear structures formed prior to onset of DNA synthesis.
Journal of virology 1999;73(6):5132-8.
1999: Sunil J Advani; SM Chung; S Y Yan; G Yancey Gillespie; JM Markert; Richard J Whitley; Bernard Roizman; Ralph R Weichselbaum
Replication-competent, nonneuroinvasive genetically engineered herpes virus is highly effective in the treatment of therapy-resistant experimental human tumors.
Cancer research 1999;59(9):2055-8.
1999: WO Ogle; Bernard Roizman
Functional anatomy of herpes simplex virus 1 overlapping genes encoding infected-cell protein 22 and US1.5 protein.
Journal of virology 1999;73(5):4305-15.
1999: R Bruni; B Fineschi; WO Ogle; Bernard Roizman
A novel cellular protein, p60, interacting with both herpes simplex virus 1 regulatory proteins ICP22 and ICP0 is modified in a cell-type-specific manner and Is recruited to the nucleus after infection.
Journal of virology 1999;73(5):3810-7.
1999: Bernard Roizman
HSV gene functions: what have we learned that could be generally applicable to its near and distant cousins?
Acta virologica 1999;43(2-3):75-80.
1999: Veronica Galvan; R Brandimarti; Bernard Roizman
Herpes simplex virus 1 blocks caspase-3-independent and caspase-dependent pathways to cell death.
Journal of virology 1999;73(4):3219-26.
1998: Kevin A Cassady; Martin Gross; Bernard Roizman
The herpes simplex virus US11 protein effectively compensates for the gamma1(34.5) gene if present before activation of protein kinase R by precluding its phosphorylation and that of the alpha subunit of eukaryotic translation initiation factor 2.
Journal of virology 1998;72(11):8620-6.
1998: R Bruni; Bernard Roizman
Herpes simplex virus 1 regulatory protein ICP22 interacts with a new cell cycle-regulated factor and accumulates in a cell cycle-dependent fashion in infected cells.
Journal of virology 1998;72(11):8525-31.
1998: Kevin A Cassady; Martin Gross; Bernard Roizman
The second-site mutation in the herpes simplex virus recombinants lacking the gamma134.5 genes precludes shutoff of protein synthesis by blocking the phosphorylation of eIF-2alpha.
Journal of virology 1998;72(9):7005-11.
1998: Bin He; Martin Gross; Bernard Roizman
The gamma134.5 protein of herpes simplex virus 1 has the structural and functional attributes of a protein phosphatase 1 regulatory subunit and is present in a high molecular weight complex with the enzyme in infected cells.
The Journal of biological chemistry 1998;273(33):20737-43.
1998: YE Chang; Laura Menotti; F Filatov; Gabriella Campadelli-Fiume; Bernard Roizman
UL27.5 is a novel gamma2 gene antisense to the herpes simplex virus 1 gene encoding glycoprotein B.
Journal of virology 1998;72(7):6056-64.
1998: Veronica Galvan; Bernard Roizman
Herpes simplex virus 1 induces and blocks apoptosis at multiple steps during infection and protects cells from exogenous inducers in a cell-type-dependent manner.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(7):3931-6.
1998: Richard J Whitley; David W Kimberlin; Bernard Roizman
Herpes simplex viruses.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1998;26(3):541-53; quiz 554-5.
1998: Y Kawaguchi; Charles Van Sant; Bernard Roizman
Eukaryotic elongation factor 1delta is hyperphosphorylated by the protein kinase encoded by the U(L)13 gene of herpes simplex virus 1.
Journal of virology 1998;72(3):1731-6.
1998: PL Ward; Elisa Avitabile; Gabriella Campadelli-Fiume; Bernard Roizman
Conservation of the architecture of the Golgi apparatus related to a differential organization of microtubules in polykaryocytes induced by syn- mutants of herpes simplex virus 1.
Virology 1998;241(2):189-99.
1998: Sunil J Advani; G S Sibley; P Y Song; Dennis E Hallahan; Y Kataoka; Bernard Roizman; Ralph R Weichselbaum
Enhancement of replication of genetically engineered herpes simplex viruses by ionizing radiation: a new paradigm for destruction of therapeutically intractable tumors.
Gene therapy 1998;5(2):160-5.
1998: TI Ng; WO Ogle; Bernard Roizman
UL13 protein kinase of herpes simplex virus 1 complexes with glycoprotein E and mediates the phosphorylation of the viral Fc receptor: glycoproteins E and I.
Virology 1998;241(1):37-48.
1998: Samita Andreansky; Bin He; J van Cott; J McGhee; James M Markert; G Yancey Gillespie; Bernard Roizman; Richard J Whitley
Treatment of intracranial gliomas in immunocompetent mice using herpes simplex viruses that express murine interleukins.
Gene therapy 1998;5(1):121-30.
1997: R Brandimarti; Bernard Roizman
Us9, a stable lysine-less herpes simplex virus 1 protein, is ubiquitinated before packaging into virions and associates with proteasomes.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(25):13973-8.
1997: YE Chang; Charles Van Sant; Peter William Krug; A E Sears; Bernard Roizman
The null mutant of the U(L)31 gene of herpes simplex virus 1: construction and phenotype in infected cells.
Journal of virology 1997;71(11):8307-15.
1997: C Mitchell; J A Blaho; A L McCormick; Bernard Roizman
The nucleotidylylation of herpes simplex virus 1 regulatory protein alpha22 by human casein kinase II.
The Journal of biological chemistry 1997;272(40):25394-400.
1997: Glenn Randall; Bernard Roizman
Transcription of the derepressed open reading frame P of herpes simplex virus 1 precludes the expression of the antisense gamma(1)34.5 gene and may account for the attenuation of the mutant virus.
Journal of virology 1997;71(10):7750-7.
1997: Y Kawaguchi; Charles Van Sant; Bernard Roizman
Herpes simplex virus 1 alpha regulatory protein ICP0 interacts with and stabilizes the cell cycle regulator cyclin D3.
Journal of virology 1997;71(10):7328-36.
1997: Glenn Randall; Michael Lagunoff; Bernard Roizman
The product of ORF O located within the domain of herpes simplex virus 1 genome transcribed during latent infection binds to and inhibits in vitro binding of infected cell protein 4 to its cognate DNA site.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(19):10379-84.
1997: WO Ogle; TI Ng; K L Carter; Bernard Roizman
The UL13 protein kinase and the infected cell type are determinants of posttranslational modification of ICP0.
Virology 1997;235(2):406-13.
1997: TI Ng; YE Chang; Bernard Roizman
Infected cell protein 22 of herpes simplex virus 1 regulates the expression of virion host shutoff gene U(L)41.
Virology 1997;234(2):226-34.
1997: Bin He; J Chou; R Brandimarti; Ian Mohr; Y Gluzman; Bernard Roizman
Suppression of the phenotype of gamma(1)34.5- herpes simplex virus 1: failure of activated RNA-dependent protein kinase to shut off protein synthesis is associated with a deletion in the domain of the alpha47 gene.
Journal of virology 1997;71(8):6049-54.
1997: R Leopardi; Charles Van Sant; Bernard Roizman
The herpes simplex virus 1 protein kinase US3 is required for protection from apoptosis induced by the virus.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(15):7891-6.
1997: NS Markovitz; DA Baunoch; Bernard Roizman
The range and distribution of murine central nervous system cells infected with the gamma(1)34.5- mutant of herpes simplex virus 1.
Journal of virology 1997;71(7):5560-9.
1997: Bernard Roizman; NS Markovitz
Herpes simplex virus virulence: the functions of the gamma (1)34.5 gene.
Journal of neurovirology 1997;3 Suppl 1():S1-2.
1997: Samita Andreansky; Liliana Soroceanu; E R Flotte; J Chou; James M Markert; G Yancey Gillespie; Bernard Roizman; Richard J Whitley
Evaluation of genetically engineered herpes simplex viruses as oncolytic agents for human malignant brain tumors.
Cancer research 1997;57(8):1502-9.
1997: Alice P W Poon; Bernard Roizman
Differentiation of the shutoff of protein synthesis by virion host shutoff and mutant gamma (1)34.5 genes of herpes simplex virus 1.
Virology 1997;229(1):98-105.
1997: Bin He; Martin Gross; Bernard Roizman
The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(3):843-8.
1997: R Leopardi; PL Ward; WO Ogle; Bernard Roizman
Association of herpes simplex virus regulatory protein ICP22 with transcriptional complexes containing EAP, ICP4, RNA polymerase II, and viral DNA requires posttranslational modification by the U(L)13 proteinkinase.
Journal of virology 1997;71(2):1133-9.
1997: Y Kawaguchi; R Bruni; Bernard Roizman
Interaction of herpes simplex virus 1 alpha regulatory protein ICP0 with elongation factor 1delta: ICP0 affects translational machinery.
Journal of virology 1997;71(2):1019-24.
1996: T I Ng; Christine L Talarico; T C Burnette; Karen K Biron; Bernard Roizman
Partial substitution of the functions of the herpes simplex virus 1 U(L)13 gene by the human cytomegalovirus U(L)97 gene.
Virology 1996;225(2):347-58.
1996: K L Carter; P L Ward; Bernard Roizman
Characterization of the products of the U(L)43 gene of herpes simplex virus 1: potential implications for regulation of gene expression by antisense transcription.
Journal of virology 1996;70(11):7663-8.
1996: K L Carter; Bernard Roizman
Alternatively spliced mRNAs predicted to yield frame-shift proteins and stable intron 1 RNAs of the herpes simplex virus 1 regulatory gene alpha 0 accumulate in the cytoplasm of infected cells.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(22):12535-40.
1996: Samita Andreansky; Bin He; G Yancey Gillespie; Liliana Soroceanu; James M Markert; J Chou; Bernard Roizman; Richard J Whitley
The application of genetically engineered herpes simplex viruses to the treatment of experimental brain tumors.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(21):11313-8.
1996: Bernard Roizman
The function of herpes simplex virus genes: a primer for genetic engineering of novel vectors.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(21):11307-12.
1996: R Bruni; Bernard Roizman
Open reading frame P--a herpes simplex virus gene repressed during productive infection encodes a protein that binds a splicing factor and reduces synthesis of viral proteins made from spliced mRNA.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(19):10423-7.
1996: R Leopardi; Bernard Roizman
The herpes simplex virus major regulatory protein ICP4 blocks apoptosis induced by the virus or by hyperthermia.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(18):9583-7.
1996: P L Ward; WO Ogle; Bernard Roizman
Assemblons: nuclear structures defined by aggregation of immature capsids and some tegument proteins of herpes simplex virus 1.
Journal of virology 1996;70(7):4623-31.
1996: Y E Chang; A P Poon; Bernard Roizman
Properties of the protein encoded by the UL32 open reading frame of herpes simplex virus 1.
Journal of virology 1996;70(6):3938-46.
1996: R Leopardi; Bernard Roizman
Functional interaction and colocalization of the herpes simplex virus 1 major regulatory protein ICP4 with EAP, a nucleolar-ribosomal protein.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(10):4572-6.
1996: P L Ward; D E Barker; Bernard Roizman
A novel herpes simplex virus 1 gene, UL43.5, maps antisense to the UL43 gene and encodes a protein which colocalizes in nuclear structures with capsid proteins.
Journal of virology 1996;70(5):2684-90.
1996: Michael Lagunoff; Glenn Randall; Bernard Roizman
Phenotypic properties of herpes simplex virus 1 containing a derepressed open reading frame P gene.
Journal of virology 1996;70(3):1810-7.
1996: Bin He; J Chou; D A Liebermann; B Hoffman; Bernard Roizman
The carboxyl terminus of the murine MyD116 gene substitutes for the corresponding domain of the gamma(1)34.5 gene of herpes simplex virus to preclude the premature shutoff of total protein synthesis in infected human cells.
Journal of virology 1996;70(1):84-90.
1996: K L Carter; Bernard Roizman
The promoter and transcriptional unit of a novel herpes simplex virus 1 alpha gene are contained in, and encode a protein in frame with, the open reading frame of the alpha 22 gene.
Journal of virology 1996;70(1):172-8.
1995: A P Poon; Bernard Roizman
The phenotype in vitro and in infected cells of herpes simplex virus 1 alpha trans-inducing factor (VP16) carrying temperature-sensitive mutations introduced by substitution of cysteines.
Journal of virology 1995;69(12):7658-67.
1995: Elisa Avitabile; S Di Gaeta; Maria Rosaria Torrisi; P L Ward; Bernard Roizman; Gabriella Campadelli-Fiume
Redistribution of microtubules and Golgi apparatus in herpes simplex virus-infected cells and their role in viral exocytosis.
Journal of virology 1995;69(12):7472-82.
1995: J Chou; J J Chen; Martin Gross; Bernard Roizman
Association of a M(r) 90,000 phosphoprotein with protein kinase PKR in cells exhibiting enhanced phosphorylation of translation initiation factor eIF-2 alpha and premature shutoff of protein synthesis after infection with gamma 134.5- mutants of herpes simplex virus 1.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(23):10516-20.
1995: Michael Lagunoff; Bernard Roizman
The regulation of synthesis and properties of the protein product of open reading frame P of the herpes simplex virus 1 genome.
Journal of virology 1995;69(6):3615-23.
1995: R Leopardi; N Michael; Bernard Roizman
Repression of the herpes simplex virus 1 alpha 4 gene by its gene product (ICP4) within the context of the viral genome is conditioned by the distance and stereoaxial alignment of the ICP4 DNA binding site relative to the TATA box.
Journal of virology 1995;69(5):3042-8.
1995: R Chambers; G Yancey Gillespie; Liliana Soroceanu; Samita Andreansky; S Chatterjee; J Chou; Bernard Roizman; Richard J Whitley
Comparison of genetically engineered herpes simplex viruses for the treatment of brain tumors in a scid mouse model of human malignant glioma.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(5):1411-5.
1995: J D Baines; Robert J Jacob; L Simmerman; Bernard Roizman
The herpes simplex virus 1 UL11 proteins are associated with cytoplasmic and nuclear membranes and with nuclear bodies of infected cells.
Journal of virology 1995;69(2):825-33.
1994: C Mitchell; J A Blaho; Bernard Roizman
Casein kinase II specifically nucleotidylylates in vitro the amino acid sequence of the protein encoded by the alpha 22 gene of herpes simplex virus 1.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(25):11864-8.
1994: J Chou; A P Poon; J Johnson; Bernard Roizman
Differential response of human cells to deletions and stop codons in the gamma(1)34.5 gene of herpes simplex virus.
Journal of virology 1994;68(12):8304-11.
1994: P L Ward; Gabriella Campadelli-Fiume; Elisa Avitabile; Bernard Roizman
Localization and putative function of the UL20 membrane protein in cells infected with herpes simplex virus 1.
Journal of virology 1994;68(11):7406-17.
1994: Elisa Avitabile; P L Ward; C Di Lazzaro; Maria Rosaria Torrisi; Bernard Roizman; Gabriella Campadelli-Fiume
The herpes simplex virus UL20 protein compensates for the differential disruption of exocytosis of virions and viral membrane glycoproteins associated with fragmentation of the Golgi apparatus.
Journal of virology 1994;68(11):7397-405.
1994: Michael Lagunoff; Bernard Roizman
Expression of a herpes simplex virus 1 open reading frame antisense to the gamma(1)34.5 gene and transcribed by an RNA 3' coterminal with the unspliced latency-associated transcript.
Journal of virology 1994;68(9):6021-8.
1994: P L Ward; Bernard Roizman
Herpes simplex genes: the blueprint of a successful human pathogen.
Trends in genetics : TIG 1994;10(8):267-74.
1994: J A Blaho; C Mitchell; Bernard Roizman
An amino acid sequence shared by the herpes simplex virus 1 alpha regulatory proteins 0, 4, 22, and 27 predicts the nucleotidylylation of the UL21, UL31, UL47, and UL49 gene products.
The Journal of biological chemistry 1994;269(26):17401-10.
1994: R Brandimarti; Tianmin Huang; Bernard Roizman; Gabriella Campadelli-Fiume
Mapping of herpes simplex virus 1 genes with mutations which overcome host restrictions to infection.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(12):5406-10.
1994: J Chou; Bernard Roizman
Herpes simplex virus 1 gamma(1)34.5 gene function, which blocks the host response to infection, maps in the homologous domain of the genes expressed during growth arrest and DNA damage.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(12):5247-51.
1994: J D Baines; A H Koyama; T Huang; Bernard Roizman
The UL21 gene products of herpes simplex virus 1 are dispensable for growth in cultured cells.
Journal of virology 1994;68(5):2929-36.
1994: R J Roller; Bernard Roizman
A herpes simplex virus 1 US11-expressing cell line is resistant to herpes simplex virus infection at a step in viral entry mediated by glycoprotein D.
Journal of virology 1994;68(5):2830-9.
1993: R L Fawl; Bernard Roizman
Induction of reactivation of herpes simplex virus in murine sensory ganglia in vivo by cadmium.
Journal of virology 1993;67(12):7025-31.
1993: Y E Chang; Bernard Roizman
The product of the UL31 gene of herpes simplex virus 1 is a nuclear phosphoprotein which partitions with the nuclear matrix.
Journal of virology 1993;67(11):6348-56.
1993: A P Poon; Bernard Roizman
Characterization of a temperature-sensitive mutant of the UL15 open reading frame of herpes simplex virus 1.
Journal of virology 1993;67(8):4497-503.
1993: F C Purves; WO Ogle; Bernard Roizman
Processing of the herpes simplex virus regulatory protein alpha 22 mediated by the UL13 protein kinase determines the accumulation of a subset of alpha and gamma mRNAs and proteins in infected cells.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(14):6701-5.
1993: J A Blaho; C Mitchell; Bernard Roizman
Guanylylation and adenylylation of the alpha regulatory proteins of herpes simplex virus require a viral beta or gamma function.
Journal of virology 1993;67(7):3891-900.
1993: Richard J Whitley; Earl R Kern; S Chatterjee; J Chou; Bernard Roizman
Replication, establishment of latency, and induced reactivation of herpes simplex virus gamma 1 34.5 deletion mutants in rodent models.
The Journal of clinical investigation 1993;91(6):2837-43.
1993: G Campadelli; R Brandimarti; C Di Lazzaro; P L Ward; Bernard Roizman; Maria Rosaria Torrisi
Fragmentation and dispersal of Golgi proteins and redistribution of glycoproteins and glycolipids processed through the Golgi apparatus after infection with herpes simplex virus 1.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(7):2798-802.
1993: K Igarashi; R Fawl; R J Roller; Bernard Roizman
Construction and properties of a recombinant herpes simplex virus 1 lacking both S-component origins of DNA synthesis.
Journal of virology 1993;67(4):2123-32.
1993: N Michael; Bernard Roizman
Repression of the herpes simplex virus 1 alpha 4 gene by its gene product occurs within the context of the viral genome and is associated with all three identified cognate sites.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(6):2286-90.
1993: F Liu; Bernard Roizman
Characterization of the protease and other products of amino-terminus-proximal cleavage of the herpes simplex virus 1 UL26 protein.
Journal of virology 1993;67(3):1300-9.
1993: J D Baines; Bernard Roizman
The UL10 gene of herpes simplex virus 1 encodes a novel viral glycoprotein, gM, which is present in the virion and in the plasma membrane of infected cells.
Journal of virology 1993;67(3):1441-52.
1992: J A Blaho; N Michael; V Kang; N Aboul-Ela; M E Smulson; Myron K Jacobson; Bernard Roizman
Differences in the poly(ADP-ribosyl)ation patterns of ICP4, the herpes simplex virus major regulatory protein, in infected cells and in isolated nuclei.
Journal of virology 1992;66(11):6398-407.
1992: J D Baines; Bernard Roizman
The cDNA of UL15, a highly conserved herpes simplex virus 1 gene, effectively replaces the two exons of the wild-type virus.
Journal of virology 1992;66(9):5621-6.
1992: F C Purves; Bernard Roizman
The UL13 gene of herpes simplex virus 1 encodes the functions for posttranslational processing associated with phosphorylation of the regulatory protein alpha 22.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(16):7310-4.
1992: J D Baines; Bernard Roizman
The UL11 gene of herpes simplex virus 1 encodes a function that facilitates nucleocapsid envelopment and egress from cells.
Journal of virology 1992;66(8):5168-74.
1992: Maria Romanelli; P Mavromara-Nazos; D Spector; Bernard Roizman
Mutational analysis of the ICP4 binding sites in the 5' transcribed noncoding domains of the herpes simplex virus 1 UL 49.5 gamma 2 gene.
Journal of virology 1992;66(8):4855-63.
1992: F C Purves; D Spector; Bernard Roizman
UL34, the target of the herpes simplex virus U(S)3 protein kinase, is a membrane protein which in its unphosphorylated state associates with novel phosphoproteins.
Journal of virology 1992;66(7):4295-303.
1992: R J Roller; Bernard Roizman
The herpes simplex virus 1 RNA binding protein US11 is a virion component and associates with ribosomal 60S subunits.
Journal of virology 1992;66(6):3624-32.
1992: L McCormick; R J Roller; Bernard Roizman
Characterization of a herpes simplex virus sequence which binds a cellular protein as either a single-stranded or double-stranded DNA or RNA.
Journal of virology 1992;66(6):3435-47.
1992: J Chou; Bernard Roizman
The gamma 1(34.5) gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programed cell death in neuronal cells.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(8):3266-70.
1992: F Liu; Bernard Roizman
Differentiation of multiple domains in the herpes simplex virus 1 protease encoded by the UL26 gene.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(6):2076-80.
1992: D E Barker; Bernard Roizman; M B Kovler
Molecular biology of herpes simplex virus.
Molecular and cell biology of human diseases series 1992;1():259-81.
1992: D E Barker; Bernard Roizman
The unique sequence of the herpes simplex virus 1 L component contains an additional translated open reading frame designated UL49.5.
Journal of virology 1992;66(1):562-6.
1991: J D Baines; P L Ward; Gabriella Campadelli-Fiume; Bernard Roizman
The UL20 gene of herpes simplex virus 1 encodes a function necessary for viral egress.
Journal of virology 1991;65(12):6414-24.
1991: Bernard Roizman
Introduction: objectives of herpes simplex virus vaccines seen from a historical perspective.
Reviews of infectious diseases 1991;13 Suppl 11():S892-4.
1991: R J Roller; Bernard Roizman
Herpes simplex virus 1 RNA-binding protein US11 negatively regulates the accumulation of a truncated viral mRNA.
Journal of virology 1991;65(11):5873-9.
1991: F C Purves; D Spector; Bernard Roizman
The herpes simplex virus 1 protein kinase encoded by the US3 gene mediates posttranslational modification of the phosphoprotein encoded by the UL34 gene.
Journal of virology 1991;65(11):5757-64.
1991: F Y Liu; Bernard Roizman
The herpes simplex virus 1 gene encoding a protease also contains within its coding domain the gene encoding the more abundant substrate.
Journal of virology 1991;65(10):5149-56.
1991: J A Blaho; Bernard Roizman
ICP4, the major regulatory protein of herpes simplex virus, shares features common to GTP-binding proteins and is adenylated and guanylated.
Journal of virology 1991;65(7):3759-69.
1991: D Spector; F Purves; Bernard Roizman
Role of alpha-transinducing factor (VP16) in the induction of alpha genes within the context of viral genomes.
Journal of virology 1991;65(7):3504-13.
1991: A E Sears; B S McGwire; Bernard Roizman
Infection of polarized MDCK cells with herpes simplex virus 1: two asymmetrically distributed cell receptors interact with different viral proteins.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(12):5087-91.
1991: A E Sears; V Hukkanen; M A Labow; A J Levine; Bernard Roizman
Expression of the herpes simplex virus 1 alpha transinducing factor (VP16) does not induce reactivation of latent virus or prevent the establishment of latency in mice.
Journal of virology 1991;65(6):2929-35.
1991: Gabriella Campadelli-Fiume; Fulvia Farabegoli; S Di Gaeta; Bernard Roizman
Origin of unenveloped capsids in the cytoplasm of cells infected with herpes simplex virus 1.
Journal of virology 1991;65(3):1589-95.
1991: J D Baines; Bernard Roizman
The open reading frames UL3, UL4, UL10, and UL16 are dispensable for the replication of herpes simplex virus 1 in cell culture.
Journal of virology 1991;65(2):938-44.
1991: Bernard Roizman; J Baines
The diversity and unity of Herpesviridae.
Comparative immunology, microbiology and infectious diseases 1991;14(2):63-79.
1991: F Y Liu; Bernard Roizman
The promoter, transcriptional unit, and coding sequence of herpes simplex virus 1 family 35 proteins are contained within and in frame with the UL26 open reading frame.
Journal of virology 1991;65(1):206-12.
1990: A E Sears; Bernard Roizman
Amplification by host cell factors of a sequence contained within the herpes simplex virus 1 genome.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(23):9441-4.
1990: Gabriella Campadelli-Fiume; S Qi; Elisa Avitabile; L Foà-Tomasi; R Brandimarti; Bernard Roizman
Glycoprotein D of herpes simplex virus encodes a domain which precludes penetration of cells expressing the glycoprotein by superinfecting herpes simplex virus.
Journal of virology 1990;64(12):6070-9.
1990: J Chou; E R Kern; Richard J Whitley; Bernard Roizman
Mapping of herpes simplex virus-1 neurovirulence to gamma 134.5, a gene nonessential for growth in culture.
Science (New York, N.Y.) 1990;250(4985):1262-6.
1990: Gabriella Campadelli-Fiume; D Stirpe; A Boscaro; Elisa Avitabile; L Foá-Tomasi; D Barker; Bernard Roizman
Glycoprotein C-dependent attachment of herpes simplex virus to susceptible cells leading to productive infection.
Virology 1990;178(1):213-22.
1990: D E Barker; Bernard Roizman
Identification of three genes nonessential for growth in cell culture near the right terminus of the unique sequences of long component of herpes simplex virus 1.
Virology 1990;177(2):684-91.
1990: D Spector; F Purves; Bernard Roizman
Mutational analysis of the promoter region of the alpha 27 gene of herpes simplex virus 1 within the context of the viral genome.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(14):5268-72.
1990: R J Roller; Bernard Roizman
The herpes simplex virus Us11 open reading frame encodes a sequence-specific RNA-binding protein.
Journal of virology 1990;64(7):3463-70.
1990: J Chou; Bernard Roizman
The herpes simplex virus 1 gene for ICP34.5, which maps in inverted repeats, is conserved in several limited-passage isolates but not in strain 17syn+.
Journal of virology 1990;64(3):1014-20.
1990: Bernard Roizman
Whither herpesviruses?
Advances in experimental medicine and biology 1990;278():285-91.
1989: N Michael; Bernard Roizman
Binding of the herpes simplex virus major regulatory protein to viral DNA.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(24):9808-12.
1989: R J Roller; A L McCormick; Bernard Roizman
Cellular proteins specifically bind single- and double-stranded DNA and RNA from the initiation site of a transcript that crosses the origin of DNA replication of herpes simplex virus 1.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(17):6518-22.
1989: P Mavromara-Nazos; Bernard Roizman
Delineation of regulatory domains of early (beta) and late (gamma 2) genes by construction of chimeric genes expressed in herpes simplex virus 1 genomes.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(11):4071-5.
1989: J Chou; Bernard Roizman
Characterization of DNA sequence-common and sequence-specific proteins binding to cis-acting sites for cleavage of the terminal a sequence of the herpes simplex virus 1 genome.
Journal of virology 1989;63(3):1059-68.
1988: J H Voss; Bernard Roizman
Properties of two 5'-coterminal RNAs transcribed part way and across the S component origin of DNA synthesis of the herpes simplex virus 1 genome.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(22):8454-8.
1988: Gabriella Campadelli-Fiume; Elisa Avitabile; S Fini; D Stirpe; Minas Arsenakis; Bernard Roizman
Herpes simplex virus glycoprotein D is sufficient to induce spontaneous pH-independent fusion in a cell line that constitutively expresses the glycoprotein.
Virology 1988;166(2):598-602.
1988: Bernard Roizman; T Kristie; J L McKnight; N Michael; P Mavromara-Nazos; D Spector
The trans-activation of herpes simplex virus gene expression: comparison of two factors and their cis sites.
Biochimie 1988;70(8):1031-43.
1988: T M Kristie; Bernard Roizman
Differentiation and DNA contact points of host proteins binding at the cis site for virion-mediated induction of alpha genes of herpes simplex virus 1.
Journal of virology 1988;62(4):1145-57.
1988: N Michael; D Spector; P Mavromara-Nazos; T M Kristie; Bernard Roizman
The DNA-binding properties of the major regulatory protein alpha 4 of herpes simplex viruses.
Science (New York, N.Y.) 1988;239(4847):1531-4.
1988: Bernard Roizman
Molecular and genetic engineering: the principles, the power, and the promise.
Science (New York, N.Y.) 1988;239(4841 Pt 2):G110.
1988: Minas Arsenakis; Gabriella Campadelli-Fiume; M T Lombardo; Bernard Roizman
The glycoprotein C gene of herpes simplex virus 1 resident in clonal L cell lines manifests two regulatory domains conferring a dominant B and a subordinate gamma 2 regulation.
Virology 1988;162(2):300-10.
1988: J Hubenthal-Voss; R A Houghten; L Pereira; Bernard Roizman
Mapping of functional and antigenic domains of the alpha 4 protein of herpes simplex virus 1.
Journal of virology 1988;62(2):454-62.
1988: Gabriella Campadelli-Fiume; Minas Arsenakis; Fulvia Farabegoli; Bernard Roizman
Entry of herpes simplex virus 1 in BJ cells that constitutively express viral glycoprotein D is by endocytosis and results in degradation of the virus.
Journal of virology 1988;62(1):159-67.
1988: Minas Arsenakis; Gabriella Campadelli-Fiume; Bernard Roizman
Regulation of glycoprotein D synthesis: does alpha 4, the major regulatory protein of herpes simplex virus 1, regulate late genes both positively and negatively?
Journal of virology 1988;62(1):148-58.
1987: P Mavromara-Nazos; Bernard Roizman
Activation of herpes simplex virus 1 gamma 2 genes by viral DNA replication.
Virology 1987;161(2):593-8.
1987: J Hubenthal-Voss; L Starr; Bernard Roizman
The herpes simplex virus origins of DNA synthesis in the S component are each contained in a transcribed open reading frame.
Journal of virology 1987;61(11):3349-55.
1987: J L McKnight; T M Kristie; Bernard Roizman
Binding of the virion protein mediating alpha gene induction in herpes simplex virus 1-infected cells to its cis site requires cellular proteins.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(20):7061-5.
1987: Bernard Roizman; A E Sears
An inquiry into the mechanisms of herpes simplex virus latency.
Annual review of microbiology 1987;41():543-71.
1986: Minas Arsenakis; J Hubenthal-Voss; Gabriella Campadelli-Fiume; L Pereira; Bernard Roizman
Construction and properties of a cell line constitutively expressing the herpes simplex virus glycoprotein B dependent on functional alpha 4 protein synthesis.
Journal of virology 1986;60(2):674-82.
1986: Minas Arsenakis; L F Tomasi; V Speziali; Bernard Roizman; Gabriella Campadelli-Fiume
Expression and regulation of glycoprotein C gene of herpes simplex virus 1 resident in a clonal L-cell line.
Journal of virology 1986;58(2):367-76.
1986: P Mavromara-Nazos; S Silver; J Hubenthal-Voss; J L McKnight; Bernard Roizman
Regulation of herpes simplex virus 1 genes: alpha gene sequence requirements for transient induction of indicator genes regulated by beta or late (gamma 2) promoters.
Virology 1986;149(2):152-64.
1969: J Schwartz; Bernard Roizman
Similarities and Differences in the Development of Laboratory Strains and Freshly Isolated Strains of Herpes Simplex Virus in HEp-2 Cells: Electron Microscopy.
Journal of virology 1969;4(6):879-89.