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John Biggers

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TOP 3
J Liu; Mehmet Toner; Joel Lawitts; G Y Lee; John D Biggers
Technical note: Mice produced by intracytoplasmic sperm injection using a modified conventional method.
John D Biggers
IVF and embryo transfer: historical origin and development.
Claude P Lechene; Gloria Y Lee; J Collin Poczatek; Mehmet Toner; John D Biggers
3D multi-isotope imaging mass spectrometry reveals penetration of 18O-trehalose in mouse sperm nucleus.

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All Publications

2012: J Liu; Mehmet Toner; Joel Lawitts; G Y Lee; John D Biggers
Technical note: Mice produced by intracytoplasmic sperm injection using a modified conventional method.
Journal of animal science 2012;90(11):3739-42.
2012: John D Biggers
IVF and embryo transfer: historical origin and development.
Reproductive biomedicine online 2012;25(2):118-27.
2012: Claude P Lechene; Gloria Y Lee; J Collin Poczatek; Mehmet Toner; John D Biggers
3D multi-isotope imaging mass spectrometry reveals penetration of 18O-trehalose in mouse sperm nucleus.
PloS one 2012;7(8):e42267.
2010: John D Biggers
Human Reproduction. Editorial.
Human reproduction (Oxford, England) 2010;25(9):2156.
2009: Heidi Y Elmoazzen; Gloria Y Lee; Ming-Wen Li; Lynda McGinnis; K C Kent Lloyd; Mehmet Toner; John D Biggers
Further optimization of mouse spermatozoa evaporative drying techniques.
Cryobiology 2009;59(1):113-5.
2009: John D Biggers
Evaporative drying of mouse spermatozoa.
Reproductive biomedicine online 2009;19 Suppl 4():4338.
2008: John D Biggers; Michael C Summers
Impact of hyperglycemia on early embryo development and embryopathy: in vitro experiments using a mouse model.
Human reproduction (Oxford, England) 2008;23(12):2874-5.
2008: Ali Fuat Ergenc; Ming-Wen Li; Mehmet Toner; John D Biggers; K C Kent Lloyd; Nejat Olgac
Rotationally oscillating drill (Ros-Drill) for mouse ICSI without using mercury.
Molecular reproduction and development 2008;75(12):1744-51.
2008: John D Biggers; Michael C Summers
Choosing a culture medium: making informed choices.
Fertility and sterility 2008;90(3):473-83.
2007: Ming-Wen Li; John D Biggers; Mehmet Toner; Stephen M Griffey; K C Kent Lloyd
Phenotypic analysis of C57BL/6J and FVB/NJ mice generated using evaporatively dried spermatozoa.
Comparative medicine 2007;57(5):469-75.
2007: Ming-Wen Li; John D Biggers; Heidi Y Elmoazzen; Mehmet Toner; Lynda McGinnis; K C Kent Lloyd
Long-term storage of mouse spermatozoa after evaporative drying.
Reproduction (Cambridge, England) 2007;133(5):919-29.
2006: Raymond Stacy; Ali Eroglu; Alex Fowler; John D Biggers; Mehmet Toner
Thermal characterization of Nakagata's mouse sperm freezing protocol.
Cryobiology 2006;52(1):99-107.
2005: John D Biggers; Lynda McGinnis; Joel Lawitts
One-step versus two-step culture of mouse preimplantation embryos: is there a difference?
Human reproduction (Oxford, England) 2005;20(12):3376-84.
2005: Lynda McGinnis; Liben Zhu; Joel Lawitts; Sankha Bhowmick; Mehmet Toner; John D Biggers
Mouse sperm desiccated and stored in trehalose medium without freezing.
Biology of reproduction 2005;73(4):627-33.
2005: Michael C Summers; Lynda McGinnis; Joel Lawitts; John D Biggers
Mouse embryo development following IVF in media containing either L-glutamine or glycyl-L-glutamine.
Human reproduction (Oxford, England) 2005;20(5):1364-71.
2004: John D Biggers; Michael C Summers
When to avoid creating surplus human embryos.
Human reproduction (Oxford, England) 2004;19(11):2457-9.
2004: John D Biggers; Lynda McGinnis; Michael C Summers
Discrepancies between the effects of glutamine in cultures of preimplantation mouse embryos.
Reproductive biomedicine online 2004;9(1):70-3.
2004: John D Biggers; Lynda McGinnis; Joel Lawitts
Enhanced effect of glycyl-L-glutamine on mouse preimplantation embryos in vitro.
Reproductive biomedicine online 2004;9(1):59-69.
2003: Monika A Ward; Takehito Kaneko; Hirokazu Kusakabe; John D Biggers; David G Whittingham; Ryuzo Yanagimachi
Long-term preservation of mouse spermatozoa after freeze-drying and freezing without cryoprotection.
Biology of reproduction 2003;69(6):2100-8.
2003: Michael C Summers; John D Biggers
Chemically defined media and the culture of mammalian preimplantation embryos: historical perspective and current issues.
Human reproduction update 2003;9(6):557-82.
2003: Ming-Wen Li; Lynda McGinnis; Liben Zhu; Joel Lawitts; John D Biggers; K C Kent Lloyd
Intracytoplasmic sperm injection (ICSI) enables rescue of valuable mutant mouse strains.
Comparative medicine 2003;53(3):265-9.
2003: Sankha Bhowmick; Liben Zhu; Lynda McGinnis; Joel Lawitts; Bharat D Nath; Mehmet Toner; John D Biggers
Desiccation tolerance of spermatozoa dried at ambient temperature: production of fetal mice.
Biology of reproduction 2003;68(5):1779-86.
2002: John D Biggers; Catherine Racowsky
The development of fertilized human ova to the blastocyst stage in KSOM(AA) medium: is a two-step protocol necessary?
Reproductive biomedicine online 2002;5(2):133-40.
2002: John D Biggers
Thoughts on embryo culture conditions.
Reproductive biomedicine online 2002;4 Suppl 1():30-8.
2001: John D Biggers
Research in the canine block.
The International journal of developmental biology 2001;45(3):469-76.
2001: John D Biggers; Lynda McGinnis
Evidence that glucose is not always an inhibitor of mouse preimplantation development in vitro.
Human reproduction (Oxford, England) 2001;16(1):153-163.
2000: Michael C Summers; Lynda McGinnis; Joel Lawitts; M Raffin; John D Biggers
IVF of mouse ova in a simplex optimized medium supplemented with amino acids.
Human reproduction (Oxford, England) 2000;15(8):1791-801.
2000: John D Biggers; Lynda McGinnis; M Raffin
Amino acids and preimplantation development of the mouse in protein-free potassium simplex optimized medium.
Biology of reproduction 2000;63(1):281-93.
2000: John D Biggers
Ethical issues and the commercialization of embryo culture media.
Reproductive biomedicine online 2000;1(3):74-6.
1999: M E Donohoe; X Zhang; Lynda McGinnis; John D Biggers; En Li; Yang Shi
Targeted disruption of mouse Yin Yang 1 transcription factor results in peri-implantation lethality.
Molecular and cellular biology 1999;19(10):7237-44.
1999: Jordan A Kreidberg; Thomas A Natoli; Lynda McGinnis; M Donovan; John D Biggers; A Amstutz
Coordinate action of Wt1 and a modifier gene supports embryonic survival in the oviduct.
Molecular reproduction and development 1999;52(4):366-75.
1999: R A Nowak; F Haimovici; John D Biggers; G T Erbach
Transforming growth factor-beta stimulates mouse blastocyst outgrowth through a mechanism involving parathyroid hormone-related protein.
Biology of reproduction 1999;60(1):85-93.
1998: John D Biggers
Reflections on the culture of the preimplantation embryo.
The International journal of developmental biology 1998;42(7):879-84.
1997: John D Biggers; Michael C Summers; Lynda McGinnis
Polyvinyl alcohol and amino acids as substitutes for bovine serum albumin in culture media for mouse preimplantation embryos.
Human reproduction update 1997;3(2):125-35.
1996: A I Younis; M Toner; David F Albertini; John D Biggers
Cryobiology of non-human primate oocytes.
Human reproduction (Oxford, England) 1996;11(1):156-65.
1995: G T Erbach; P Bhatnagar; Jay M Baltz; John D Biggers
Zinc is a possible toxic contaminant of silicone oil in microdrop cultures of preimplantation mouse embryos.
Human reproduction (Oxford, England) 1995;10(12):3248-54.
1995: M C Summers; P R Bhatnagar; J A Lawitts; John D Biggers
Fertilization in vitro of mouse ova from inbred and outbred strains: complete preimplantation embryo development in glucose-supplemented KSOM.
Biology of reproduction 1995;53(2):431-7.
1995: Lorna D Johnson; D F Albertini; Lynda McGinnis; John D Biggers
Chromatin organization, meiotic status and meiotic competence acquisition in mouse oocytes from cultured ovarian follicles.
Journal of reproduction and fertility 1995;104(2):277-84.
1995: P Bhatnagar; Virginia E Papaioannou; John D Biggers
CSF-1 and mouse preimplantation development in vitro.
Development (Cambridge, England) 1995;121(5):1333-9.
1995: RN Clarke; P M Griffin; John D Biggers
Screening of maternal sera using a mouse embryo culture assay is not predictive of human embryo development or IVF outcome.
Journal of assisted reproduction and genetics 1995;12(1):20-5.
1994: A I Younis; P K Sehgal; John D Biggers
Antral follicle development and in-vitro maturation of oocytes from macaques stimulated with a single subcutaneous injection of pregnant mare's serum gonadotrophin.
Human reproduction (Oxford, England) 1994;9(11):2130-4.
1994: G T Erbach; J A Lawitts; Virginia E Papaioannou; John D Biggers
Differential growth of the mouse preimplantation embryo in chemically defined media.
Biology of reproduction 1994;50(5):1027-33.
1993: Jay M Baltz; John D Biggers; C Lechene
A novel H+ permeability dominating intracellular pH in the early mouse embryo.
Development (Cambridge, England) 1993;118(4):1353-61.
1993: John D Biggers; J A Lawitts; C P Lechene
The protective action of betaine on the deleterious effects of NaCl on preimplantation mouse embryos in vitro.
Molecular reproduction and development 1993;34(4):380-90.
1993: J A Lawitts; John D Biggers
Culture of preimplantation embryos.
Methods in enzymology 1993;225():153-64.
1992: J A Lawitts; John D Biggers
Joint effects of sodium chloride, glutamine, and glucose in mouse preimplantation embryo culture media.
Molecular reproduction and development 1992;31(3):189-94.
1991: John D Biggers; Virginia E Papaioannou
Water-escape time in adult mice derived from manipulated preimplantation embryos.
Journal of in vitro fertilization and embryo transfer : IVF 1991;8(6):352-60.
1991: J A Lawitts; J E Butler; Ann A Kiessling; John D Biggers
Growth and DNA replication in rabbit blastocysts.
Molecular reproduction and development 1991;30(4):320-9.
1991: Jay M Baltz; John D Biggers; C Lechene
Relief from alkaline load in two-cell stage mouse embryos by bicarbonate/chloride exchange.
The Journal of biological chemistry 1991;266(26):17212-7.
1991: John D Biggers
Walter Heape, FRS: a pioneer in reproductive biology. Centenary of his embryo transfer experiments.
Journal of reproduction and fertility 1991;93(1):173-86.
1991: J A Lawitts; John D Biggers
Overcoming the 2-cell block by modifying standard components in a mouse embryo culture medium.
Biology of reproduction 1991;45(2):245-51.
1991: Lorna D Johnson; B A Mattson; David F Albertini; P K Sehgal; R A Becker; J Avis; John D Biggers
Quality of oocytes from superovulated rhesus monkeys.
Human reproduction (Oxford, England) 1991;6(5):623-31.
1991: Jay M Baltz; John D Biggers; C Lechene
Two-cell stage mouse embryos appear to lack mechanisms for alleviating intracellular acid loads.
The Journal of biological chemistry 1991;266(10):6052-7.
1991: Jay M Baltz; John D Biggers
Oxygen transport to embryos in microdrop cultures.
Molecular reproduction and development 1991;28(4):351-5.
1991: J A Lawitts; John D Biggers
Optimization of mouse embryo culture media using simplex methods.
Journal of reproduction and fertility 1991;91(2):543-56.
1991: John D Biggers; Virginia E Papaioannou
Postnatal compensatory growth of manipulated mouse embryos.
Human reproduction (Oxford, England) 1991;6(1):36-44.
1990: Jay M Baltz; John D Biggers; C Lechene
Apparent absence of Na+/H+ antiport activity in the two-cell mouse embryo.
Developmental biology 1990;138(2):421-9.
1990: John D Biggers
Arbitrary partitions of prenatal life.
Human reproduction (Oxford, England) 1990;5(1):1-6.
1989: Lorna D Johnson; John D Biggers; P Sehgal; A J Petto; J Avis
The effect of heterologous gonadotropins on the fecundity of rhesus monkeys.
Journal of in vitro fertilization and embryo transfer : IVF 1989;6(6):328-34.
1989: D K Gardner; RN Clarke; C P Lechene; John D Biggers
Development of a noninvasive ultramicrofluorometric method for measuring net uptake of glutamine by single preimplantation mouse embryos.
Gamete research 1989;24(4):427-38.
1989: Virginia E Papaioannou; J Mkandawire; John D Biggers
Development and phenotypic variability of genetically identical half mouse embryos.
Development (Cambridge, England) 1989;106(4):817-27.
1989: RN Clarke; Jay M Baltz; C P Lechene; John D Biggers
Use of ultramicrofluorometric methods for the study of single preimplantation embryos.
Poultry science 1989;68(7):972-8.
1989: E W Overström; Dale J Benos; John D Biggers
Synthesis of Na+/K+ ATPase by the preimplantation rabbit blastocyst.
Journal of reproduction and fertility 1989;85(1):283-95.
1988: J E Butler; C Lechene; John D Biggers
Noninvasive measurement of glucose uptake by two populations of murine embryos.
Biology of reproduction 1988;39(4):779-86.
1988: John D Biggers
Introductory remarks on the milieux of the egg and the early embryo.
Journal of reproduction and fertility 1988;82(2):809-11.
1987: L L Nielsen; Dale J Benos; John D Biggers
Mineralocorticoid concentrations in unstressed female rabbits and embryonic sodium transport.
Journal of reproduction and fertility 1987;81(2):553-62.
1985: Dale J Benos; John D Biggers; Robert Balaban; J W Mills; E W Overström
Developmental aspects of sodium-dependent transport processes of preimplantation rabbit embryos.
Society of General Physiologists series 1985;39():211-35.
1980: R M Borland; John D Biggers; C P Lechene; M L Taymor
Elemental composition of fluid in the human Fallopian tube.
Journal of reproduction and fertility 1980;58(2):479-82.