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Leonard Rome

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TOP 3
Leonard H Rome; Valerie A Kickhoefer
Development of the vault particle as a platform technology.
Nicholas M Matsumoto; Panchami Prabhakaran; Leonard H Rome; Heather D Maynard
Smart vaults: thermally-responsive protein nanocapsules.
Jian Yang; Valerie A Kickhoefer; Jan Mrazek; Zhanyong Shu; Aswin Srinivasan; Yang Sun; Leonard H Rome
Vault nanoparticles engineered with the protein transduction domain, TAT48, enhances cellular uptake.

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All Publications

2013: Leonard H Rome; Valerie A Kickhoefer
Development of the vault particle as a platform technology.
ACS nano 2013;7(2):889-902.
2013: Nicholas M Matsumoto; Panchami Prabhakaran; Leonard H Rome; Heather D Maynard
Smart vaults: thermally-responsive protein nanocapsules.
ACS nano 2013;7(1):867-74.
2013: Jian Yang; Valerie A Kickhoefer; Jan Mrazek; Zhanyong Shu; Aswin Srinivasan; Yang Sun; Leonard H Rome
Vault nanoparticles engineered with the protein transduction domain, TAT48, enhances cellular uptake.
Integrative biology : quantitative biosciences from nano to macro 2013;5(1):151-8.
2012: Upendra K Kar; Cheryl I Champion; Janina Jiang; Valerie A Kickhoefer; Kayvan R Niazi; Shahrooz Rabizadeh; Leonard H Rome; Sahar Salehi; Sherven Sharma; Minu Srivastava; Kathleen A Kelly
Vault nanocapsules as adjuvants favor cell-mediated over antibody-mediated immune responses following immunization of mice.
PloS one 2012;7(7):e38553.
2011: Muri Han; Valerie A Kickhoefer; Glen R Nemerow; Leonard H Rome
Targeted vault nanoparticles engineered with an endosomolytic peptide deliver biomolecules to the cytoplasm.
ACS nano 2011;5(8):6128-37.
2011: Daniel C Buehler; Daniel B Toso; Valerie A Kickhoefer; Z Hong Zhou; Leonard H Rome
Vaults engineered for hydrophobic drug delivery.
Small (Weinheim an der Bergstrasse, Germany) 2011;7(10):1432-9.
2011: Upendra K Kar; Minu K Srivastava; Asa Andersson; Felicita Baratelli; Min Huang; Valerie A Kickhoefer; Steven M Dubinett; Leonard H Rome; Sherven Sharma
Novel CCL21-vault nanocapsule intratumoral delivery inhibits lung cancer growth.
PloS one 2011;6(5):e18758.
2010: Jian Yang; Valerie A Kickhoefer; Benny C Ng; Ajaykumar Gopal; Laurent A Bentolila; Scott John; Sarah H Tolbert; Leonard H Rome
Vaults are dynamically unconstrained cytoplasmic nanoparticles capable of half vault exchange.
ACS nano 2010;4(12):7229-40.
2009: Lisa E Goldsmith; Melody Pupols; Valerie A Kickhoefer; Leonard H Rome; Harold G Monbouquette
Utilization of a protein "shuttle" to load vault nanocapsules with gold probes and proteins.
ACS nano 2009;3(10):3175-83.
2009: Valerie A Kickhoefer; Muri Han; Sujna Raval-Fernandes; Michael J Poderycki; Raymond J Moniz; Dana Vaccari; Mariena Silvestry; Phoebe L Stewart; Kathleen A Kelly; Leonard H Rome
Targeting vault nanoparticles to specific cell surface receptors.
ACS nano 2009;3(1):27-36.
2009: Cheryl I Champion; Valerie A Kickhoefer; Guangchao Liu; Raymond J Moniz; Amanda S Freed; Liisa L Bergmann; Dana Vaccari; Sujna Raval-Fernandes; Ann M Chan; Leonard H Rome; Kathleen A Kelly
A vault nanoparticle vaccine induces protective mucosal immunity.
PloS one 2009;4(4):e5409.
2008: Marcella Yu; Benny C Ng; Leonard H Rome; Sarah H Tolbert; Harold G Monbouquette
Reversible pH lability of cross-linked vault nanocapsules.
Nano letters 2008;8(10):3510-5.
2008: Benny C Ng; Marcella Yu; Ajaykumar Gopal; Leonard H Rome; Harold G Monbouquette; Sarah H Tolbert
Encapsulation of semiconducting polymers in vault protein cages.
Nano letters 2008;8(10):3503-9.
2007: Daniel H Anderson; Valerie A Kickhoefer; Stuart A Sievers; Leonard H Rome; David Eisenberg
Draft crystal structure of the vault shell at 9-A resolution.
PLoS biology 2007;5(11):e318.
2007: Catherine S Kaddis; Shirley H Lomeli; Sheng Yin; Beniam Berhane; Marcin I Apostol; Valerie A Kickhoefer; Leonard H Rome; Joseph A Loo
Sizing large proteins and protein complexes by electrospray ionization mass spectrometry and ion mobility.
Journal of the American Society for Mass Spectrometry 2007;18(7):1206-16.
2007: Lisa E Goldsmith; Marcella Yu; Leonard H Rome; Harold G Monbouquette
Vault nanocapsule dissociation into halves triggered at low pH.
Biochemistry 2007;46(10):2865-75.
2006: Michael J Poderycki; Valerie A Kickhoefer; Catherine S Kaddis; Sujna Raval-Fernandes; Erik Johansson; Jeffrey I Zink; Joseph A Loo; Leonard H Rome
The vault exterior shell is a dynamic structure that allows incorporation of vault-associated proteins into its interior.
Biochemistry 2006;45(39):12184-93.
2006: Marco Slesina; Elisabeth M Inman; Ann E Moore; Joshua I Goldhaber; Leonard H Rome; Walter Volknandt
Movement of vault particles visualized by GFP-tagged major vault protein.
Cell and tissue research 2006;324(3):403-10.
2005: Sujna Raval-Fernandes; Valerie A Kickhoefer; Christina Kitchen; Leonard H Rome
Increased susceptibility of vault poly(ADP-ribose) polymerase-deficient mice to carcinogen-induced tumorigenesis.
Cancer research 2005;65(19):8846-52.
2005: Marco Slesina; Elisabeth M Inman; Leonard H Rome; Walter Volknandt
Nuclear localization of the major vault protein in U373 cells.
Cell and tissue research 2005;321(1):97-104.
2005: Valerie A Kickhoefer; Yvette Garcia; Yeshi Mikyas; Erik Johansson; Jing C Zhou; Sujna Raval-Fernandes; Payam N Minoofar; Jeffrey I Zink; Bruce Dunn; Phoebe L Stewart; Leonard H Rome
Engineering of vault nanocapsules with enzymatic and fluorescent properties.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(12):4348-52.
2005: Michael J Poderycki; Leonard H Rome; Lea Harrington; Valerie A Kickhoefer
The p80 homology region of TEP1 is sufficient for its association with the telomerase and vault RNAs, and the vault particle.
Nucleic acids research 2005;33(3):893-902.
2004: Yeshi Mikyas; Miriam Makabi; Sujna Raval-Fernandes; Lea Harrington; Valerie A Kickhoefer; Leonard H Rome; Phoebe L Stewart
Cryoelectron microscopy imaging of recombinant and tissue derived vaults: localization of the MVP N termini and VPARP.
Journal of molecular biology 2004;344(1):91-105.
2004: Yie Liu; Bryan E Snow; Valerie A Kickhoefer; Natalie Erdmann; Wen Zhou; Andrew Wakeham; Marla Gomez; Leonard H Rome; Lea Harrington
Vault poly(ADP-ribose) polymerase is associated with mammalian telomerase and is dispensable for telomerase function and vault structure in vivo.
Molecular and cellular biology 2004;24(12):5314-23.
2004: Nil Emre; Sujna Raval-Fernandes; Valerie A Kickhoefer; Leonard H Rome
Analysis of MVP and VPARP promoters indicates a role for chromatin remodeling in the regulation of MVP.
Biochimica et biophysica acta 2004;1678(1):33-46.
2003: Valerie A Kickhoefer; Nil Emre; Andrew G Stephen; Michael J Poderycki; Leonard H Rome
Identification of conserved vault RNA expression elements and a non-expressed mouse vault RNA gene.
Gene 2003;309(2):65-70.
2002: Valerie A Kickhoefer; Michael J Poderycki; Edward Chan; Leonard H Rome
The La RNA-binding protein interacts with the vault RNA and is a vault-associated protein.
The Journal of biological chemistry 2002;277(43):41282-6.
2002: Yi Hu; Andrew G Stephen; Jin Cao; LEE TANZER; Christopher A Slapak; Steadman D Harrison; Viswanath Devanarayan; Anne H Dantzig; James J Starling; Leonard H Rome; Richard E Moore
A very early induction of major vault protein accompanied by increased drug resistance in U-937 cells.
International journal of cancer. Journal international du cancer 2002;97(2):149-56.
2001: Andrew G Stephen; Sujna Raval-Fernandes; T Huynh; M Torres; Valerie A Kickhoefer; Leonard H Rome
Assembly of vault-like particles in insect cells expressing only the major vault protein.
The Journal of biological chemistry 2001;276(26):23217-20.
2001: AC Siva; Sujna Raval-Fernandes; Andrew G Stephen; M J LaFemina; Rik J Scheper; Valerie A Kickhoefer; Leonard H Rome
Up-regulation of vaults may be necessary but not sufficient for multidrug resistance.
International journal of cancer. Journal international du cancer 2001;92(2):195-202.
2001: Valerie A Kickhoefer; Y Liu; LB Kong; Bryan E Snow; Phoebe L Stewart; Lea Harrington; Leonard H Rome
The Telomerase/vault-associated protein TEP1 is required for vault RNA stability and its association with the vault particle.
The Journal of cell biology 2001;152(1):157-64.
2000: LB Kong; AC Siva; Valerie A Kickhoefer; Leonard H Rome; Phoebe L Stewart
RNA location and modeling of a WD40 repeat domain within the vault.
RNA (New York, N.Y.) 2000;6(6):890-900.
2000: Beth N Marbois; Kym F Faull; Arvan L Fluharty; Sujna Raval-Fernandes; Leonard H Rome
Analysis of sulfatide from rat cerebellum and multiple sclerosis white matter by negative ion electrospray mass spectrometry.
Biochimica et biophysica acta 2000;1484(1):59-70.
2000: Anouk B Schroeijers; AC Siva; George L Scheffer; Mariska C de Jong; S C Bolick; Danny F Dukers; Jerry W Slootstra; Rob H Meloen; Erik A C Wiemer; Valerie A Kickhoefer; Leonard H Rome; Rik J Scheper
The Mr 193,000 vault protein is up-regulated in multidrug-resistant cancer cell lines.
Cancer research 2000;60(4):1104-10.
1999: Valerie A Kickhoefer; Andrew G Stephen; Lea Harrington; Murray O Robinson; Leonard H Rome
Vaults and telomerase share a common subunit, TEP1.
The Journal of biological chemistry 1999;274(46):32712-7.
1999: Valerie A Kickhoefer; AC Siva; Nancy Kedersha; Elisabeth M Inman; C Ruland; Michel Streuli; Leonard H Rome
The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase.
The Journal of cell biology 1999;146(5):917-28.
1999: Sujna Raval-Fernandes; Valerie A Kickhoefer; Leonard H Rome
Cloning of a cDNA encoding a sequence-specific single-stranded-DNA-binding protein from Rattus norvegicus.
Gene 1999;237(1):201-7.
1999: LB Kong; AC Siva; Leonard H Rome; Phoebe L Stewart
Structure of the vault, a ubiquitous celular component.
Structure (London, England : 1993) 1999;7(4):371-9.
1999: C Herrmann; E Golkaramnay; Elisabeth M Inman; Leonard H Rome; Walter Volknandt
Recombinant major vault protein is targeted to neuritic tips of PC12 cells.
The Journal of cell biology 1999;144(6):1163-72.
1998: Sujna Raval-Fernandes; Leonard H Rome
Role of axonal components during myelination.
Microscopy research and technique 1998;41(5):379-92.
1998: Valerie A Kickhoefer; K S Rajavel; George L Scheffer; W S Dalton; R J Scheper; Leonard H Rome
Vaults are up-regulated in multidrug-resistant cancer cell lines.
The Journal of biological chemistry 1998;273(15):8971-4.
1997: Sujna Raval-Fernandes; L A Sawant; R H Aebersold; A Ducret; Leonard H Rome
Axonal proteins involved in myelination: characterization of a collagen-like protein.
Developmental neuroscience 1997;19(5):421-9.
1996: Valerie A Kickhoefer; Sanjay Vasu; Leonard H Rome
Vaults are the answer, what is the question?
Trends in cell biology 1996;6(5):174-8.
1996: Miguel A Izquierdo; George L Scheffer; Marcel J Flens; Robert H Shoemaker; Leonard H Rome; Rik J Scheper
Relationship of LRP-human major vault protein to in vitro and clinical resistance to anticancer drugs.
Cytotechnology 1996;19(3):191-7.
1995: Sanjay Vasu; Leonard H Rome
Dictyostelium vaults: disruption of the major proteins reveals growth and morphological defects and uncovers a new associated protein.
The Journal of biological chemistry 1995;270(28):16588-94.
1995: S Malek-Hedayat; Leonard H Rome
Cloning and sequence of the cDNA encoding the rat oligodendrocyte integrin beta 1 subunit.
Gene 1995;158(2):287-90.
1995: Leonard H Rome
Multidrug resistance: locked in the vault?
Nature medicine 1995;1(6):527.
1994: Valerie A Kickhoefer; Leonard H Rome
The sequence of a cDNA encoding the major vault protein from Rattus norvegicus.
Gene 1994;151(1-2):257-60.
1994: Adrian Vilalta; Valerie A Kickhoefer; Leonard H Rome; Deborah L Johnson
The rat vault RNA gene contains a unique RNA polymerase III promoter composed of both external and internal elements that function synergistically.
The Journal of biological chemistry 1994;269(47):29752-9.
1994: Lucia Notterpek; Leonard H Rome
Functional evidence for the role of axolemma in CNS myelination.
Neuron 1994;13(2):473-85.
1994: Steven Hamilton; Leonard H Rome
Stimulation of in vitro myelin synthesis by microglia.
Glia 1994;11(4):326-35.
1994: S Malek-Hedayat; Leonard H Rome
Expression of a beta 1-related integrin by oligodendroglia in primary culture: evidence for a functional role in myelination.
The Journal of cell biology 1994;124(6):1039-46.
1994: Lucia Notterpek; Leonard H Rome
A protein involved in central nervous system myelination: localization in the extracellular matrix and induction in neuroblastoma cells.
Developmental neuroscience 1994;16(5-6):267-78.
1993: Lucia Notterpek; P N Bullock; S Malek-Hedayat; Robin S Fisher; Leonard H Rome
Myelination in cerebellar slice cultures: development of a system amenable to biochemical analysis.
Journal of neuroscience research 1993;36(6):621-34.
1993: Wayne W Grody; K E Kronquist; E U Lee; J Edmond; Leonard H Rome
PCR-based cystic fibrosis (CF) carrier screening in a first-year medical student biochemistry laboratory.
American journal of human genetics 1993;53(6):1352-5.
1993: Diane C Chugani; Leonard H Rome; Nancy Kedersha
Evidence that vault ribonucleoprotein particles localize to the nuclear pore complex.
Journal of cell science 1993;106 ( Pt 1)():23-9.
1993: Sanjay Vasu; Nancy Kedersha; Leonard H Rome
cDNA cloning and disruption of the major vault protein alpha gene (mvpA) in Dictyostelium discoideum.
The Journal of biological chemistry 1993;268(21):15356-60.
1993: Valerie A Kickhoefer; Robert Searles; Nancy Kedersha; M E Garber; Deborah L Johnson; Leonard H Rome
Vault ribonucleoprotein particles from rat and bullfrog contain a related small RNA that is transcribed by RNA polymerase III.
The Journal of biological chemistry 1993;268(11):7868-73.
1992: S Malek-Hedayat; Leonard H Rome
Expression of multiple integrins and extracellular matrix components by C6 glioma cells.
Journal of neuroscience research 1992;31(3):470-8.
1991: Nancy Kedersha; John Edward Heuser; Diane C Chugani; Leonard H Rome
Vaults. III. Vault ribonucleoprotein particles open into flower-like structures with octagonal symmetry.
The Journal of cell biology 1991;112(2):225-35.
1991: Diane C Chugani; Nancy Kedersha; Leonard H Rome
Vault immunofluorescence in the brain: new insights regarding the origin of microglia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1991;11(1):256-68.
1990: P N Bullock; Leonard H Rome
Glass micro-fibers: a model system for study of early events in myelination.
Journal of neuroscience research 1990;27(3):383-93.
1990: Nancy Kedersha; Marie-Christine Miquel; D Bittner; Leonard H Rome
Vaults. II. Ribonucleoprotein structures are highly conserved among higher and lower eukaryotes.
The Journal of cell biology 1990;110(4):895-901.
1990: Leonard H Rome; M C Cardwell; P N Bullock; Steven Hamilton
Matrix interactions regulating myelinogenesis in cultured oligodendrocytes.
Advances in experimental medicine and biology 1990;265():157-67.
1990: Nancy Kedersha; Leonard H Rome
Vaults: large cytoplasmic RNP's that associate with cytoskeletal elements.
Molecular biology reports 1990;14(2-3):121-2.
1988: M C Cardwell; Leonard H Rome
RGD-containing peptides inhibit the synthesis of myelin-like membrane by cultured oligodendrocytes.
The Journal of cell biology 1988;107(4):1551-9.
1988: M C Cardwell; Leonard H Rome
Evidence that an RGD-dependent receptor mediates the binding of oligodendrocytes to a novel ligand in a glial-derived matrix.
The Journal of cell biology 1988;107(4):1541-9.
1988: K R Westcott; Leonard H Rome
Cation-independent mannose 6-phosphate receptor contains covalently bound fatty acid.
Journal of cellular biochemistry 1988;38(1):23-33.
1987: P Lemansky; A Hasilik; K von Figura; S Helmy; J Fishman; Richard E Fine; Nancy Kedersha; Leonard H Rome
Lysosomal enzyme precursors in coated vesicles derived from the exocytic and endocytic pathways.
The Journal of cell biology 1987;104(6):1743-8.
1987: K R Westcott; Robert Searles; Leonard H Rome
Evidence for ligand- and pH-dependent conformational changes in liposome-associated mannose 6-phosphate receptor.
The Journal of biological chemistry 1987;262(13):6101-7.
1986: Nancy Kedersha; Leonard H Rome
Isolation and characterization of a novel ribonucleoprotein particle: large structures contain a single species of small RNA.
The Journal of cell biology 1986;103(3):699-709.
1986: Nancy Kedersha; D F Hill; K E Kronquist; Leonard H Rome
Subpopulations of liver coated vesicles resolved by preparative agarose gel electrophoresis.
The Journal of cell biology 1986;103(1):287-97.
1986: Nancy Kedersha; Leonard H Rome
Preparative agarose gel electrophoresis for the purification of small organelles and particles.
Analytical biochemistry 1986;156(1):161-70.
1986: Leonard H Rome; P N Bullock; Francesco Chiappelli; M Cardwell; A M Adinolfi; D Swanson
Synthesis of a myelin-like membrane by oligodendrocytes in culture.
Journal of neuroscience research 1986;15(1):49-65.
1985: D F Hill; P N Bullock; Francesco Chiappelli; Leonard H Rome
Binding and internalization of lysosomal enzymes by primary cultures of rat glia.
Journal of neuroscience research 1985;14(1):35-47.