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Pedro Romero

Research Profile

Chemicals & Drugs

Disorders

Melanoma

Anatomy

Physiology

Procedures

Flow Cytometry

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Jan C Dudda; Thelma M Escobar; Luca Gattinoni; Michael Hebeisen; Werner Held; Yun Ji; Estelle Merck; Gwennaelle C Monnot; Stefan A Muljo; Douglas C Palmer; Rachel Perret; Nicholas P Restifo; Nathalie Rufer; Bruno Salaun; Daniel T Utzschneider; Dietmar Zehn; Caroline Boudousquie; Alena Donda; Pedro Romero
MicroRNA-155 Is Required for Effector CD8(+) T Cell Responses to Virus Infection and Cancer.
Stéphanie Corgnac; Laurent Derré; Jean-Pierre Mach; Rachel Perret; Pedro Romero; Daniel E Speiser; Kathrin Stirnemann; Maurice Zauderer; Lianjun Zhang; Alena Donda
CD1d-antibody fusion proteins target iNKT cells to the tumor and trigger long-term therapeutic responses.
Luc Bron; Camilla Jandus; Philippe Monnier; Pedro Romero; Daniel E Speiser; Snezana Andrejevic-Blant; Jean-Paul Rivals
Prognostic value of arginase-II expression and regulatory T-cell infiltration in head and neck squamous cell carcinoma.

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2013: Jan C Dudda; Thelma M Escobar; Luca Gattinoni; Michael Hebeisen; Werner Held; Yun Ji; Estelle Merck; Gwennaelle C Monnot; Stefan A Muljo; Douglas C Palmer; Rachel Perret; Nicholas P Restifo; Nathalie Rufer; Bruno Salaun; Daniel T Utzschneider; Dietmar Zehn; Caroline Boudousquie; Alena Donda; Pedro Romero
MicroRNA-155 Is Required for Effector CD8(+) T Cell Responses to Virus Infection and Cancer.
Immunity 2013;38(4):742-53.
2013: Stéphanie Corgnac; Laurent Derré; Jean-Pierre Mach; Rachel Perret; Pedro Romero; Daniel E Speiser; Kathrin Stirnemann; Maurice Zauderer; Lianjun Zhang; Alena Donda
CD1d-antibody fusion proteins target iNKT cells to the tumor and trigger long-term therapeutic responses.
Cancer immunology, immunotherapy : CII 2013;62(4):747-60.
2013: Luc Bron; Camilla Jandus; Philippe Monnier; Pedro Romero; Daniel E Speiser; Snezana Andrejevic-Blant; Jean-Paul Rivals
Prognostic value of arginase-II expression and regulatory T-cell infiltration in head and neck squamous cell carcinoma.
International journal of cancer. Journal international du cancer 2013;132(3):E85-93.
2012: Muhammad Zaeem Noman; Pedro Romero; S Buart; Bassam Janji; Sami Ketari; Fathia Mami-Chouaib; Bernard Mari; Salem Chouaib
Hypoxia-inducible miR-210 regulates the susceptibility of tumor cells to lysis by cytotoxic T cells.
Cancer research 2012;72(18):4629-41.
2012: Francesco Staehli; Aubry Tardivel; Marion Braun; Isabel Ferrero; Greta Guarda; Leonhard X Heinz; Kristina Ludigs; H Robson MacDonald; C Mattmann; Manuele Rebsamen; Walter Reith; Pedro Romero; Kate Schroder; Queralt Seguín-Estévez; Jürg Tschopp
NLRC5 deficiency selectively impairs MHC class I- dependent lymphocyte killing by cytotoxic T cells.
Journal of immunology (Baltimore, Md. : 1950) 2012;188(8):3820-8.
2012: Hussein Fayyad-Kazan; Mohammad Fayyad-Kazan; Eva Hamade; Fadi Jebbawi; Philippe Lewalle; Bassam M Badran; Rabih Badran; Arsène Burny; Nabil El Zein; Makram Merimi; Mehdi Najar; Pedro Romero; Redouane Rouas; Medhi Najar; Philippe Martiat
MicroRNA profile of circulating CD4-positive regulatory T cells in human adults and impact of differentially expressed microRNAs on expression of two genes essential to their function.
The Journal of biological chemistry 2012;287(13):9910-22.
2012: Marion Braun; Anya Hammann-Haenni; Camilla Jandus; Patrik Maurer; Katrin Schwarz; Daniel E Speiser; Martin F Bachmann; Pedro Romero
Virus-like particles induce robust human T-helper cell responses.
European journal of immunology 2012;42(2):330-40.
2012: Emanuela Romano; Stephanie Corgnac; Alena Donda; Denise Nardelli-Haefliger; Pedro Romero
SITC 26th annual meeting--summary.
Journal of translational medicine 2012;10():105.
2011: Muhammad Zaeem Noman; Sandrine Pierson; Piotr Przanowski; Pedro Romero; Kris Van Moer; Guy Berchem; S Buart; Bassam Janji; Bozena Kaminska; Fathia Mami-Chouaib; Salem Chouaib
Blocking hypoxia-induced autophagy in tumors restores cytotoxic T-cell activity and promotes regression.
Cancer research 2011;71(18):5976-86.
2011: Daniel E Speiser; Sébastien Wieckowski; Lukas Baitsch; Petra Baumgaertner; Bhawna Gupta; Emanuela M Iancu; Olivier Michielin; Pedro Romero; Nathalie Rufer
Single cell analysis reveals similar functional competence of dominant and nondominant CD8 T-cell clonotypes.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(37):15318-23.
2011: Sophie R Sierro; Hideo Yagita; Alena Donda; Philippe Guillaume; Frédéric Levy; Rachel Perret; Pedro Romero
Combination of lentivector immunization and low-dose chemotherapy or PD-1/PD-L1 blocking primes self-reactive T cells and induces anti-tumor immunity.
European journal of immunology 2011;41(8):2217-28.
2011: Lukas Baitsch; Petra Baumgaertner; Estelle Devêvre; Sunil K Raghav; Amandine Legat; Leticia Barba; Sébastien Wieckowski; Hanifa Bouzourene; Bart Deplancke; Pedro Romero; Nathalie Rufer; Daniel E Speiser
Exhaustion of tumor-specific CD8⁺ T cells in metastases from melanoma patients.
The Journal of clinical investigation 2011;121(6):2350-60.
2011: Bruno Salaun; Laurence Zitvogel; Carine Asselin-Paturel; Yannis Morel; Karine Chemin; Clarisse Dubois; Catherine Massacrier; Rosa Conforti; Marie Pierre Chenard; Jean-Christophe Sabourin; Aicha Goubar; Serge Lebecque; Michel Pierres; Donata Rimoldi; Pedro Romero; Fabrice Andre
TLR3 as a biomarker for the therapeutic efficacy of double-stranded RNA in breast cancer.
Cancer research 2011;71(5):1607-14.
2011: Bruno Salaun; Takuya Yamamoto; Bassam Badran; Yasuko Tsunetsugu-Yokota; Antoine Roux; Lukas Baitsch; Redouane Rouas; Hussein Fayyad-Kazan; Petra Baumgaertner; Estelle Devevre; Anirudh Ramesh; Marion Braun; Daniel Speiser; Brigitte Autran; Philippe Martiat; Victor Appay; Pedro Romero
Differentiation associated regulation of microRNA expression in vivo in human CD8+ T cell subsets.
Journal of translational medicine 2011;9():44.
2011: Valérie Cesson; Jean-Paul Rivals; Anette Escher; Elsa Piotet; Kris Thielemans; Vilmos Posevitz; Danijel Dojcinovic; Philippe Monnier; Daniel Speiser; Luc Bron; Pedro Romero
MAGE-A3 and MAGE-A4 specific CD4(+) T cells in head and neck cancer patients: detection of naturally acquired responses and identification of new epitopes.
Cancer immunology, immunotherapy : CII 2011;60(1):23-35.
2010: Daniel E Speiser; Katrin Schwarz; Petra Baumgaertner; Vania Manolova; Estelle Devevre; Wolfram Sterry; Peter Walden; Alfred Zippelius; Katrin Baumann Conzett; Gabriela Senti; Verena Voelter; Jean-Philippe Cerottini; David Guggisberg; Jörg Willers; Christine Geldhof; Pedro Romero; Thomas Kündig; Alexander Knuth; Reinhard Dummer; Uwe Trefzer; Martin F Bachmann
Memory and effector CD8 T-cell responses after nanoparticle vaccination of melanoma patients.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2010;33(8):848-58.
2010: julien laurent; Daniel E Speiser; Victor Appay; Cedric Touvrey; Manuela Vicari; Anne Papaioannou; Giorgia Canellini; Donata Rimoldi; Nathalie Rufer; Pedro Romero; Serge Leyvraz; Verena Voelter
Impact of 3 different short-term chemotherapy regimens on lymphocyte-depletion and reconstitution in melanoma patients.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2010;33(7):723-34.
2010: Daniel E Speiser; Pedro Romero
Molecularly defined vaccines for cancer immunotherapy, and protective T cell immunity.
Seminars in immunology 2010;22(3):144-54.
2010: Laurent Derré; Camilla Jandus; Petra Baumgaertner; Vilmos Posevitz; Estelle Devêvre; Pedro Romero; Daniel E Speiser
Quantitative multiparameter assays to measure the effect of adjuvants on human antigen-specific CD8 T-cell responses.
Methods in molecular biology (Clifton, N.J.) 2010;626():231-49.
2010: Laurent Derré; Jean-Paul Rivals; Camilla Jandus; Sonia Pastor; Donata Rimoldi; Pedro Romero; Olivier Michielin; Daniel Olive; Daniel E Speiser
BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination.
The Journal of clinical investigation 2010;120(1):157-67.
2009: Camilla Jandus; Daniel Speiser; Pedro Romero
Recent advances and hurdles in melanoma immunotherapy.
Pigment cell & melanoma research 2009;22(6):711-23.
2009: Camilla Jandus; Gilles Bioley; Danijel Dojcinovic; Laurent Derré; Lukas Baitsch; Sébastien Wieckowski; Nathalie Rufer; William W Kwok; Jean-Marie Tiercy; Immanuel F Luescher; Daniel E Speiser; Pedro Romero
Tumor antigen-specific FOXP3+ CD4 T cells identified in human metastatic melanoma: peptide vaccination results in selective expansion of Th1-like counterparts.
Cancer research 2009;69(20):8085-93.
2009: Sébastien Wieckowski; Petra Baumgaertner; Patricia Corthesy; Verena Voelter; Pedro Romero; Daniel E Speiser; Nathalie Rufer
Fine structural variations of alphabetaTCRs selected by vaccination with natural versus altered self-antigen in melanoma patients.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(8):5397-406.
2009: Danielle Lienard; Marie-Françoise Avril; Frédérique-Anne Le Gal; Petra Baumgaertner; Wim Vermeulen; Astrid Blom; Christine Geldhof; Donata Rimoldi; sonia pagliusi; Pedro Romero; Pierre-Yves Dietrich; Nathalie Corvaia; Daniel E Speiser
Vaccination of melanoma patients with Melan-A/Mart-1 peptide and Klebsiella outer membrane protein p40 as an adjuvant.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2009;32(8):875-83.
2009: Emanuela M Iancu; Patricia Corthesy; Petra Baumgaertner; Estelle Devevre; Verena Voelter; Pedro Romero; Daniel E Speiser; Nathalie Rufer
Clonotype selection and composition of human CD8 T cells specific for persistent herpes viruses varies with differentiation but is stable over time.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(1):319-31.
2009: Cedric Touvrey; Laurent Derré; Estelle Devevre; Patricia Corthesy; Pedro Romero; Nathalie Rufer; Daniel E Speiser
Dominant human CD8 T cell clonotypes persist simultaneously as memory and effector cells in memory phase.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(11):6718-26.
2009: Gabriel Bricard; Valerie Cesson; Estelle Devevre; Hanifa Bouzourene; Catherine Barbey; Nathalie Rufer; Jin S Im; Pedro M S Alves; Olivier Martinet; Nermin Halkic; Jean-Charles Cerottini; Pedro Romero; Steven A Porcelli; H Robson MacDonald; Daniel E Speiser
Enrichment of human CD4+ V(alpha)24/Vbeta11 invariant NKT cells in intrahepatic malignant tumors.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(8):5140-51.
2009: Bruno Salaun; Maude Greutert; Pedro Romero
Toll-like receptor 3 is necessary for dsRNA adjuvant effects.
Vaccine 2009;27(12):1841-7.
2009: Marlene Brandes; Katharina Willimann; Gilles Bioley; Nicole Lévy; Matthias Eberl; Ming Luo; Robert Tampé; Frédéric Lévy; Pedro Romero; Bernhard Moser
Cross-presenting human gammadelta T cells induce robust CD8+ alphabeta T cell responses.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(7):2307-12.
2008: Camilla Jandus; Gilles Bioley; Daniel E Speiser; Pedro Romero
Selective accumulation of differentiated FOXP3(+) CD4 (+) T cells in metastatic tumor lesions from melanoma patients compared to peripheral blood.
Cancer immunology, immunotherapy : CII 2008;57(12):1795-805.
2008: Laurent Derré; Marc Bruyninx; Petra Baumgaertner; Mathias Ferber; Daphné Schmid; Antoine Leimgruber; Vincent Zoete; Pedro Romero; Olivier Michielin; Daniel E Speiser; Nathalie Rufer
Distinct sets of alphabeta TCRs confer similar recognition of tumor antigen NY-ESO-1157-165 by interacting with its central Met/Trp residues.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(39):15010-5.
2008: Camilla Jandus; Gilles Bioley; Jean-Paul Rivals; Jean Dudler; Daniel Speiser; Pedro Romero
Increased numbers of circulating polyfunctional Th17 memory cells in patients with seronegative spondylarthritides.
Arthritis and rheumatism 2008;58(8):2307-17.
2008: Verena Voelter; Nathalie Rufer; Severine Reynard; Gilbert Greub; Roger Brookes; Philippe Guillaume; Frederic Grosjean; Theres Fagerberg; Olivier Michelin; Sarah Rowland-Jones; Clemencia Pinilla; Serge Leyvraz; Pedro Romero; Victor Appay
Characterization of Melan-A reactive memory CD8+ T cells in a healthy donor.
International immunology 2008;20(8):1087-96.
2008: Sylvia Adams; Michelle A Lowes; David W O'Neill; Stephen Schachterle; Pedro Romero; Nina Bhardwaj
Lack of functionally active Melan-A(26-35)-specific T cells in the blood of HLA-A2+ vitiligo patients.
The Journal of investigative dermatology 2008;128(8):1977-80.
2008: Daniel E Speiser; Petra Baumgaertner; Verena Voelter; Estelle Devevre; Catherine Barbey; Nathalie Rufer; Pedro Romero
Unmodified self antigen triggers human CD8 T cells with stronger tumor reactivity than altered antigen.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(10):3849-54.
2008: Pedro Romero
Current state of vaccine therapies in non-small-cell lung cancer.
Clinical lung cancer 2008;9 Suppl 1():S28-36.
2008: Verena Voelter; Alessia Pica; julien laurent; Donata Rimoldi; Hanifa Bouzourene; Ali Sajadi; Maurice Matter; Pedro Romero; Nathalie Rufer; Daniel E Speiser
An unusual case of metastatic melanoma sensitive to chemotherapy and immunotherapy, with late immune escape in the brain.
Cancer immunity 2008;8():6.
2007: Bruno Salaun; Pedro Romero; Serge Lebecque
Toll-like receptors' two-edged sword: when immunity meets apoptosis.
European journal of immunology 2007;37(12):3311-8.
2007: Laurent Derré; Mathias Ferber; Cedric Touvrey; Estelle Devevre; Vincent Zoete; Antoine Leimgruber; Pedro Romero; Olivier Michielin; Frédéric Lévy; Daniel E Speiser
A novel population of human melanoma-specific CD8 T cells recognizes Melan-AMART-1 immunodominant nonapeptide but not the corresponding decapeptide.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(11):7635-45.
2007: Victor Appay; Andreas Bosio; Stefanie Lokan; Yvonne Wiencek; Christian Biervert; Daniel Küsters; Estelle Devevre; Daniel Speiser; Pedro Romero; Nathalie Rufer; Serge Leyvraz
Sensitive gene expression profiling of human T cell subsets reveals parallel post-thymic differentiation for CD4+ and CD8+ lineages.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(11):7406-14.
2007: Pedro M S Alves; Sebastien Viatte; Theres Fagerberg; Olivier Michielin; Gabriel Bricard; Hanifa Bouzourene; Henri Vuilleumier; Thorsten Kruger; Jean-Claude Givel; Frédéric Lévy; Daniel E Speiser; Jean-Charles Cerottini; Pedro Romero
Immunogenicity of the carcinoembryonic antigen derived peptide 694 in HLA-A2 healthy donors and colorectal carcinoma patients.
Cancer immunology, immunotherapy : CII 2007;56(11):1795-805.
2007: Laurent Derré; Marc Bruyninx; Petra Baumgaertner; Estelle Devevre; Patricia Corthesy; Cedric Touvrey; Yolanda D Mahnke; Hanspeter Pircher; Verena Voelter; Pedro Romero; Daniel E Speiser; Nathalie Rufer
In Vivo Persistence of Codominant Human CD8+ T Cell Clonotypes Is Not Limited by Replicative Senescence or Functional Alteration.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(4):2368-79.
2007: Bruno Salaun; Serge Lebecque; Sampsa Matikainen; Donata Rimoldi; Pedro Romero
Toll-like receptor 3 expressed by melanoma cells as a target for therapy?
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(15 Pt 1):4565-74.
2007: Pedro M S Alves; Nicole Lévy; Hanifa Bouzourene; Sebastien Viatte; Gabriel Bricard; Maha Ayyoub; Henri Vuilleumier; Jean-Claude Givel; Nermin Halkic; Daniel E Speiser; Pedro Romero; Frédéric Lévy
Molecular and immunological evaluation of the expression of cancer/testis gene products in human colorectal cancer.
Cancer immunology, immunotherapy : CII 2007;56(6):839-47.
2007: Pedro Romero; Alfred Zippelius; Isabel Kurth; Mikaël J Pittet; Cedric Touvrey; Emanuela M Iancu; Patricia Corthesy; Estelle Devevre; Daniel E Speiser; Nathalie Rufer
Four functionally distinct populations of human effector-memory CD8+ T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(7):4112-9.
2007: Catherine Barbey; Petra Baumgaertner; Estelle Devevre; Verena Rubio-Godoy; Laurent Derré; Gabriel Bricard; Philippe Guillaume; Immanuel F Luescher; Danielle Liénard; Jean-Charles Cerottini; Pedro Romero; Nathalie Rufer; Daniel E Speiser
IL-12 controls cytotoxicity of a novel subset of self-antigen-specific human CD28+ cytolytic T cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(6):3566-74.
2007: Victor Appay; Verena Voelter; Nathalie Rufer; Severine Reynard; Camilla Jandus; Danielle Gasparini; Danielle Lienard; Daniel E Speiser; Philippe Schneider; Jean-Charles Cerottini; Pedro Romero; Serge Leyvraz
Combination of transient lymphodepletion with busulfan and fludarabine and peptide vaccination in a phase I clinical trial for patients with advanced melanoma.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2007;30(2):240-50.
2006: Julie Tabiasco; Estelle Devêvre; Nathalie Rufer; Bruno Salaun; Jean-Charles Cerottini; Daniel Speiser; Pedro Romero
Human effector CD8+ T lymphocytes express TLR3 as a functional coreceptor.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(12):8708-13.
2006: Gilles Bioley; Camilla Jandus; Sandra Tuyaerts; Donata Rimoldi; William W Kwok; Daniel E Speiser; Jean-Marie Tiercy; Kris Thielemans; Jean-Charles Cerottini; Pedro Romero
Melan-A/MART-1-specific CD4 T cells in melanoma patients: identification of new epitopes and ex vivo visualization of specific T cells by MHC class II tetramers.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(10):6769-79.
2006: Victor Appay; Camilla Jandus; Verena Voelter; Severine Reynard; Sarah E Coupland; Donata Rimoldi; Danielle Lienard; Philippe Guillaume; Arthur M Krieg; Jean-Charles Cerottini; Pedro Romero; Serge Leyvraz; Nathalie Rufer; Daniel E Speiser
New generation vaccine induces effective melanoma-specific CD8+ T cells in the circulation but not in the tumor site.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(3):1670-8.
2006: Daniel E Speiser; Petra Baumgaertner; Catherine Barbey; Verena Rubio-Godoy; Alexandre Moulin; Patricia Corthesy; Estelle Devevre; Pierre-Yves Dietrich; Donata Rimoldi; Danielle Liénard; Jean-Charles Cerottini; Pedro Romero; Nathalie Rufer
A novel approach to characterize clonality and differentiation of human melanoma-specific T cell responses: spontaneous priming and efficient boosting by vaccination.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(2):1338-48.
2006: Victor Appay; Daniel E Speiser; Nathalie Rufer; Severine Reynard; Catherine Barbey; Jean-Charles Cerottini; Serge Leyvraz; Clemencia Pinilla; Pedro Romero
Decreased specific CD8+ T cell cross-reactivity of antigen recognition following vaccination with Melan-A peptide.
European journal of immunology 2006;36(7):1805-14.
2006: Sebastien Viatte; Pedro M S Alves; Pedro Romero
Reverse immunology approach for the identification of CD8 T-cell-defined antigens: advantages and hurdles.
Immunology and cell biology 2006;84(3):318-30.
2006: Estelle Devêvre; Pedro Romero; Yolanda D Mahnke
LiveCount Assay: concomitant measurement of cytolytic activity and phenotypic characterisation of CD8(+) T-cells by flow cytometry.
Journal of immunological methods 2006;311(1-2):31-46.
2006: Pascal Batard; Daniel A Peterson; Estelle Devêvre; Philippe Guillaume; Jean-Charles Cerottini; Donata Rimoldi; Daniel E Speiser; Lars Winther; Pedro Romero
Dextramers: new generation of fluorescent MHC class I/peptide multimers for visualization of antigen-specific CD8+ T cells.
Journal of immunological methods 2006;310(1-2):136-48.
2006: Victor Appay; Severine Reynard; Verena Voelter; Pedro Romero; Daniel E Speiser; Serge Leyvraz
Immuno-monitoring of CD8+ T cells in whole blood versus PBMC samples.
Journal of immunological methods 2006;309(1-2):192-9.
2006: Petra Baumgaertner; Nathalie Rufer; Estelle Devevre; Laurent Derré; Donata Rimoldi; Christine Geldhof; Verena Voelter; Danielle Liénard; Pedro Romero; Daniel E Speiser
Ex vivo detectable human CD8 T-cell responses to cancer-testis antigens.
Cancer research 2006;66(4):1912-6.
2006: Mikaël J Pittet; Asma Gati; Frédérique-Anne Le Gal; Gilles Bioley; Philippe Guillaume; Magda De Smedt; Jean Plum; Daniel E Speiser; Jean-Charles Cerottini; Pierre-Yves Dietrich; Pedro Romero; Alfred Zippelius
Ex vivo characterization of allo-MHC-restricted T cells specific for a single MHC-peptide complex.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(4):2330-6.
2006: Marco Migliaccio; Pedro Miguel Sousa Alves; Pedro Romero; Nathalie Rufer
Distinct mechanisms control human naive and antigen-experienced CD8+ T lymphocyte proliferation.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(4):2173-82.
2006: Pedro Romero; Jean-Charles Cerottini; Daniel E Speiser
The human T cell response to melanoma antigens.
Advances in immunology 2006;92():187-224.
2005: Pedro Romero; Jean-Charles Cerottini; Immanuel F Luescher
On the significance of CD8 alpha alpha expression for T cell memory.
European journal of immunology 2005;35(11):3092-4.
2005: M Montes; Nathalie Rufer; Victor Appay; Severine Reynard; Mikaël J Pittet; D E Speiser; Philippe Guillaume; Jean-Charles Cerottini; Pedro Romero; S Leyvraz
Optimum in vitro expansion of human antigen-specific CD8 T cells for adoptive transfer therapy.
Clinical and experimental immunology 2005;142(2):292-302.
2005: Steffen Walter; Gilles Bioley; Hans-Jörg Bühring; Sven Koch; Dorothee Wernet; Alfred Zippelius; Graham Pawelec; Pedro Romero; Stefan Stevanović; Hans-Georg Rammensee; Cécile Gouttefangeas
High frequencies of functionally impaired cytokeratin 18-specific CD8+ T cells in healthy HLA-A2+ donors.
European journal of immunology 2005;35(10):2876-85.
2005: Daniel E Speiser; Pedro Romero
Toward improved immunocompetence of adoptively transferred CD8+ T cells.
The Journal of clinical investigation 2005;115(6):1467-9.
2005: Daniel E Speiser; Danielle Liénard; Nathalie Rufer; Verena Rubio-Godoy; Donata Rimoldi; Ferdy Lejeune; Arthur M Krieg; Jean-Charles Cerottini; Pedro Romero
Rapid and strong human CD8+ T cell responses to vaccination with peptide, IFA, and CpG oligodeoxynucleotide 7909.
The Journal of clinical investigation 2005;115(3):739-46.
2005: Gabriel Bricard; Hanifa Bouzourene; Olivier Martinet; Donata Rimoldi; Nermin Halkic; Michel Gillet; Pascal Chaubert; H Robson MacDonald; Pedro Romero; Jean-Charles Cerottini; Daniel E Speiser
Naturally acquired MAGE-A10- and SSX-2-specific CD8+ T cell responses in patients with hepatocellular carcinoma.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(3):1709-16.
2005: Yolanda D Mahnke; Daniel Speiser; Immanuel F Luescher; Jean-Charles Cerottini; Pedro Romero
Recent advances in tumour antigen-specific therapy: in vivo veritas.
International journal of cancer. Journal international du cancer 2005;113(2):173-8.
2005: Olivier Michielin; Jean-Sebastien Blanchet; Theres Fagerberg; Danila Valmori; Verena Rubio-Godoy; Daniel Speiser; Maha Ayyoub; Pedro Alves; Immanuel F Luescher; Jean Edouard Gairin; Jean-Charles Cerottini; Pedro Romero
Tinkering with nature: the tale of optimizing peptide based cancer vaccines.
Cancer treatment and research 2005;123():267-91.
2004: Laurence Chapatte; Catherine Servis; Danila Valmori; Odile Burlet-Schiltz; Johanna Dayer; Bernard Monsarrat; Pedro Romero; Frédéric Lévy
Final antigenic Melan-A peptides produced directly by the proteasomes are preferentially selected for presentation by HLA-A*0201 in melanoma cells.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(10):6033-40.
2004: Norbert Meidenbauer; Alfred Zippelius; Mikaël J Pittet; Monika Laumer; Sandra Vogl; Jana Heymann; Michael Rehli; Barbara Seliger; Stephan Schwarz; Frédérique-Anne Le Gal; Pierre-Yves Dietrich; Reinhard Andreesen; Pedro Romero; Andreas Mackensen
High frequency of functionally active Melan-a-specific T cells in a patient with progressive immunoproteasome-deficient melanoma.
Cancer research 2004;64(17):6319-26.
2004: Daniel E Speiser; Mikaël J Pittet; Philippe Guillaume; Norbert Lubenow; Eric Hoffman; Jean-Charles Cerottini; Pedro Romero
Ex vivo analysis of human antigen-specific CD8+ T-cell responses: quality assessment of fluorescent HLA-A2 multimer and interferon-gamma ELISPOT assays for patient immune monitoring.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2004;27(4):298-308.
2004: Danielle Liénard; Donata Rimoldi; Marie Marchand; Pierre-Yves Dietrich; Nicolas van Baren; Christine Geldhof; Pascal Batard; Philippe Guillaume; Maha Ayyoub; Mikaël J Pittet; Alfred Zippelius; Katharina Fleischhauer; Ferdy Lejeune; Jean-Charles Cerottini; Pedro Romero; Daniel E Speiser
Ex vivo detectable activation of Melan-A-specific T cells correlating with inflammatory skin reactions in melanoma patients vaccinated with peptides in IFA.
Cancer immunity 2004;4():4.
2004: Alfred Zippelius; Pascal Batard; Verena Rubio-Godoy; Gilles Bioley; Danielle Liénard; Ferdy Lejeune; Donata Rimoldi; Philippe Guillaume; Norbert Meidenbauer; Andreas Mackensen; Nathalie Rufer; Norbert Lubenow; Daniel Speiser; Jean-Charles Cerottini; Pedro Romero; Mikaël J Pittet
Effector function of human tumor-specific CD8 T cells in melanoma lesions: a state of local functional tolerance.
Cancer research 2004;64(8):2865-73.
2004: Alfred Zippelius; Gilles Bioley; Frédérique-Anne Le Gal; Nathalie Rufer; Marlene Brandes; Pascal Batard; Magda De Smedt; Jean Plum; Daniel E Speiser; Jean-Charles Cerottini; Pierre-Yves Dietrich; Pedro Romero; Mikaël J Pittet
Human thymus exports naive CD8 T cells that can home to nonlymphoid tissues.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(5):2773-7.
2003: Daniel E Speiser; Mikaël J Pittet; Donata Rimoldi; Philippe Guillaume; Immanuel F Luescher; Danielle Liénard; Ferdy Lejeune; Jean-Charles Cerottini; Pedro Romero
Evaluation of melanoma vaccines with molecularly defined antigens by ex vivo monitoring of tumor-specific T cells.
Seminars in cancer biology 2003;13(6):461-72.
2003: Danila Valmori; Valérie Dutoit; Maha Ayyoub; Donata Rimoldi; Philippe Guillaume; Danielle Liénard; Ferdy Lejeune; Jean-Charles Cerottini; Pedro Romero; Daniel E Speiser
Simultaneous CD8+ T cell responses to multiple tumor antigen epitopes in a multipeptide melanoma vaccine.
Cancer immunity 2003;3():15.
2003: Daniel E Speiser; Donata Rimoldi; Pascal Batard; Danielle Liénard; Ferdy Lejeune; Jean-Charles Cerottini; Pedro Romero
Disease-driven T cell activation predicts immune responses to vaccination against melanoma.
Cancer immunity 2003;3():12.
2003: Maha Ayyoub; Donata Rimoldi; Philippe Guillaume; Pedro Romero; Jean-Charles Cerottini; Danila Valmori; Daniel Speiser
Tumor-reactive, SSX-2-specific CD8+ T cells are selectively expanded during immune responses to antigen-expressing tumors in melanoma patients.
Cancer research 2003;63(17):5601-6.
2003: Nathalie Rufer; Alfred Zippelius; Pascal Batard; Mikaël J Pittet; Isabel Kurth; Patricia Corthesy; Jean-Charles Cerottini; Serge Leyvraz; Eddy Roosnek; Markus Nabholz; Pedro Romero
Ex vivo characterization of human CD8+ T subsets with distinct replicative history and partial effector functions.
Blood 2003;102(5):1779-87.
2003: Mikaël J Pittet; Verena Rubio-Godoy; Gilles Bioley; Philippe Guillaume; Pascal Batard; Daniel Speiser; Immanuel F Luescher; Jean-Charles Cerottini; Pedro Romero; Alfred Zippelius
Alpha 3 domain mutants of peptide/MHC class I multimers allow the selective isolation of high avidity tumor-reactive CD8 T cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(4):1844-9.
2003: Pierre-Yves Dietrich; Frédérique-Anne Le Gal; Valérie Dutoit; Mikaël J Pittet; Lydie Trautman; Alfred Zippelius; Isabelle Cognet; Valérie Widmer; Paul R Walker; Olivier Michielin; Philippe Guillaume; Thierry Connerotte; Francine Jotereau; Pierre G Coulie; Pedro Romero; Jean-Charles Cerottini; Marc Bonneville; Danila Valmori
Prevalent role of TCR alpha-chain in the selection of the preimmune repertoire specific for a human tumor-associated self-antigen.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(10):5103-9.
2003: Maha Ayyoub; Alfred Zippelius; Mikaël J Pittet; Donata Rimoldi; Danila Valmori; Jean-Charles Cerottini; Pedro Romero; Ferdy Lejeune; Danielle Liénard; Daniel E Speiser
Activation of human melanoma reactive CD8+ T cells by vaccination with an immunogenic peptide analog derived from Melan-A/melanoma antigen recognized by T cells-1.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(2):669-77.
2002: Verena Rubio-Godoy; Valérie Dutoit; Yingdong Zhao; Richard Simon; Philippe Guillaume; Richard A Houghten; Pedro Romero; Jean-Charles Cerottini; Clemencia Pinilla; Danila Valmori
Positional scanning-synthetic peptide library-based analysis of self- and pathogen-derived peptide cross-reactivity with tumor-reactive Melan-A-specific CTL.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(10):5696-707.
2002: Valérie Dutoit; Philippe Guillaume; Jean-Charles Cerottini; Pedro Romero; Danila Valmori
Dissecting TCR-MHC/peptide complex interactions with A2/peptide multimers incorporating tumor antigen peptide variants: crucial role of interaction kinetics on functional outcomes.
European journal of immunology 2002;32(11):3285-93.
2002: Daniel E Speiser; Jean-Charles Cerottini; Pedro Romero
Can hTERT peptide (540-548) -specific CD8 T cells recognize and kill tumor cells?
Cancer immunity 2002;2():14.
2002: Pedro Romero; Danila Valmori; Mikaël J Pittet; Alfred Zippelius; Donata Rimoldi; Frédéric Lévy; Valérie Dutoit; Maha Ayyoub; Verena Rubio-Godoy; Olivier Michielin; Philippe Guillaume; Pascal Batard; Immanuel F Luescher; Ferdy Lejeune; Danielle Liénard; Nathalie Rufer; Pierre-Yves Dietrich; Daniel E Speiser; Jean-Charles Cerottini
Antigenicity and immunogenicity of Melan-A/MART-1 derived peptides as targets for tumor reactive CTL in human melanoma.
Immunological reviews 2002;188():81-96.
2002: Verena Rubio-Godoy; Maha Ayyoub; Valérie Dutoit; Catherine Servis; Amy Schink; Donata Rimoldi; Pedro Romero; Jean-Charles Cerottini; Richard Simon; Yindong Zhao; Richard A Houghten; Clemencia Pinilla; Danila Valmori
Combinatorial peptide library-based identification of peptide ligands for tumor-reactive cytolytic T lymphocytes of unknown specificity.
European journal of immunology 2002;32(8):2292-9.
2002: Valérie Dutoit; Verena Rubio-Godoy; Mikaël J Pittet; Alfred Zippelius; Pierre-Yves Dietrich; Frédérique Anne Legal; Philippe Guillaume; Pedro Romero; Jean-Charles Cerottini; Richard A Houghten; Clemencia Pinilla; Danila Valmori
Degeneracy of antigen recognition as the molecular basis for the high frequency of naive A2/Melan-a peptide multimer(+) CD8(+) T cells in humans.
The Journal of experimental medicine 2002;196(2):207-16.
2002: Valérie Dutoit; Philippe Guillaume; Pedro Romero; Jean-Charles Cerottini; Danila Valmori
Functional analysis of HLA-A*0201/Melan-A peptide multimer+ CD8+ T cells isolated from an HLA-A*0201- donor: exploring tumor antigen allorestricted recognition.
Cancer immunity 2002;2():7.
2002: Mikaël J Pittet; Alfred Zippelius; Danila Valmori; Daniel E Speiser; Jean-Charles Cerottini; Pedro Romero
Melan-A/MART-1-specific CD8 T cells: from thymus to tumor.
Trends in immunology 2002;23(7):325-8.
2002: Christoph Esslinger; Pedro Romero; H Robson MacDonald
Efficient transduction of dendritic cells and induction of a T-cell response by third-generation lentivectors.
Human gene therapy 2002;13(9):1091-100.
2002: Pascal Batard; Janos Szollosi; Immanuel F Luescher; Jean-Charles Cerottini; Rob MacDonald; Pedro Romero
Use of phycoerythrin and allophycocyanin for fluorescence resonance energy transfer analyzed by flow cytometry: advantages and limitations.
Cytometry 2002;48(2):97-105.
2002: Susanne Wirth; Frédéric Bille; Sylvain Koenig; Nathalie Wehrli; Isabelle Miconnet; Frédéric Lévy; Heidi Diggelmann; Pedro Romero; Hans Acha-Orbea
Testing mouse mammary tumor virus superantigen as adjuvant in cytotoxic T-lymphocyte responses against a melanoma tumor antigen.
International journal of cancer. Journal international du cancer 2002;99(2):201-6.
2002: Danila Valmori; Valérie Dutoit; Valerie Schnuriger; Anne-Lise Quiquerez; Mikaël J Pittet; Philippe Guillaume; Verena Rubio-Godoy; Paul R Walker; Donata Rimoldi; Danielle Liénard; Jean-Charles Cerottini; Pedro Romero; Pierre-Yves Dietrich
Vaccination with a Melan-A peptide selects an oligoclonal T cell population with increased functional avidity and tumor reactivity.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(8):4231-40.
2002: Verena Rubio-Godoy; Clemencia Pinilla; Valérie Dutoit; Eva Borras; Richard Simon; Yingdong Zhao; Jean-Charles Cerottini; Pedro Romero; Richard A Houghten; Danila Valmori
Toward synthetic combinatorial peptide libraries in positional scanning format (PS-SCL)-based identification of CD8+ Tumor-reactive T-Cell Ligands: a comparative analysis of PS-SCL recognition by a single tumor-reactive CD8+ cytolytic T-lymphocyte clone.
Cancer research 2002;62(7):2058-63.
2002: Danila Valmori; Carmen Scheibenbogen; Valérie Dutoit; Dirk Nagorsen; Anne Marie Asemissen; Verena Rubio-Godoy; Donata Rimoldi; Philippe Guillaume; Pedro Romero; Dirk Schadendorf; Martin Lipp; Pierre-Yves Dietrich; Eckhard Thiel; Jean-Charles Cerottini; Danielle Liénard; Ulrich Keilholz
Circulating Tumor-reactive CD8(+) T cells in melanoma patients contain a CD45RA(+)CCR7(-) effector subset exerting ex vivo tumor-specific cytolytic activity.
Cancer research 2002;62(6):1743-50.
2002: Daniel E Speiser; Danielle Liénard; Mikaël J Pittet; Pascal Batard; Donata Rimoldi; Philippe Guillaume; Jean-Charles Cerottini; Pedro Romero
In vivo activation of melanoma-specific CD8(+) T cells by endogenous tumor antigen and peptide vaccines. A comparison to virus-specific T cells.
European journal of immunology 2002;32(3):731-41.
2002: Alfred Zippelius; Mikaël J Pittet; Pascal Batard; Nathalie Rufer; Magda De Smedt; Philippe Guillaume; Kim Ellefsen; Danila Valmori; Danielle Liénard; Jean Plum; H Robson MacDonald; Daniel E Speiser; Jean-Charles Cerottini; Pedro Romero
Thymic selection generates a large T cell pool recognizing a self-peptide in humans.
The Journal of experimental medicine 2002;195(4):485-94.
2002: Maha Ayyoub; Stefan Stevanovic; Ugur Sahin; Philippe Guillaume; Catherine Servis; Donata Rimoldi; Danila Valmori; Pedro Romero; Jean-Charles Cerottini; Hans-Georg Rammensee; Michael Pfreundschuh; Daniel Speiser; Frédéric Lévy
Proteasome-assisted identification of a SSX-2-derived epitope recognized by tumor-reactive CTL infiltrating metastatic melanoma.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(4):1717-22.
2002: Isabelle Miconnet; Sylvain Koenig; Daniel Speiser; Arthur Krieg; Philippe Guillaume; Jean-Charles Cerottini; Pedro Romero
CpG are efficient adjuvants for specific CTL induction against tumor antigen-derived peptide.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(3):1212-8.
2002: Valérie Dutoit; Verena Rubio-Godoy; Marie-Agnès Doucey; Pascal Batard; Danielle Liénard; Donata Rimoldi; Daniel Speiser; Philippe Guillaume; Jean-Charles Cerottini; Pedro Romero; Danila Valmori
Functional avidity of tumor antigen-specific CTL recognition directly correlates with the stability of MHC/peptide multimer binding to TCR.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(3):1167-71.
2001: Daniel E Speiser; Marco COLONna; Maha Ayyoub; M Cella; Mikaël J Pittet; Pascal Batard; Danila Valmori; Philippe Guillaume; Danielle Liénard; Jean-Charles Cerottini; Pedro Romero
The activatory receptor 2B4 is expressed in vivo by human CD8+ effector alpha beta T cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(11):6165-70.
2001: Donata Rimoldi; Katja Muehlethaler; Suzanne Salvi; Danila Valmori; Pedro Romero; Jean-Charles Cerottini; F Levy
Subcellular localization of the melanoma-associated protein Melan-AMART-1 influences the processing of its HLA-A2-restricted epitope.
The Journal of biological chemistry 2001;276(46):43189-96.
2001: Maha Ayyoub; M Migliaccio; Philippe Guillaume; Danielle Liénard; Jean-Charles Cerottini; Pedro Romero; Frédéric Lévy; Daniel E Speiser; Danila Valmori
Lack of tumor recognition by hTERT peptide 540-548-specific CD8(+) T cells from melanoma patients reveals inefficient antigen processing.
European journal of immunology 2001;31(9):2642-51.
2001: Verena Rubio-Godoy; Valérie Dutoit; Donata Rimoldi; Danielle Lienard; Ferdy Lejeune; Daniel Speiser; Philippe Guillaume; Jean-Charles Cerottini; Pedro Romero; Danila Valmori
Discrepancy between ELISPOT IFN-gamma secretion and binding of A2/peptide multimers to TCR reveals interclonal dissociation of CTL effector function from TCR-peptide/MHC complexes half-life.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(18):10302-7.
2001: Valérie Dutoit; Verena Rubio-Godoy; Pierre-Yves Dietrich; A L Quiqueres; Valerie Schnuriger; Donata Rimoldi; Danielle Liénard; Daniel Speiser; Philippe Guillaume; Pascal Batard; Jean-Charles Cerottini; Pedro Romero; Danila Valmori
Heterogeneous T-cell response to MAGE-A10(254-262): high avidity-specific cytolytic T lymphocytes show superior antitumor activity.
Cancer research 2001;61(15):5850-6.
2001: Mikaël J Pittet; Alfred Zippelius; Daniel E Speiser; M Assenmacher; Philippe Guillaume; Danila Valmori; Danielle Liénard; Ferdy Lejeune; Jean-Charles Cerottini; Pedro Romero
Ex vivo IFN-gamma secretion by circulating CD8 T lymphocytes: implications of a novel approach for T cell monitoring in infectious and malignant diseases.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(12):7634-40.
2001: Isabelle Miconnet; Isabelle Coste; Friedrich Beermann; J F Haeuw; Jean-Charles Cerottini; Jean-Yves Bonnefoy; Pedro Romero; Toufic Renno
Cancer vaccine design: a novel bacterial adjuvant for peptide-specific CTL induction.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(7):4612-9.
2001: Bruno Robert; Philippe Guillaume; Immanuel F Luescher; Marie-Agnès Doucey; Jean-Charles Cerottini; Pedro Romero; Jean-Pierre Mach
Redirecting anti-viral CTL against cancer cells by surface targeting of monomeric MHC class I-viral peptide conjugated to antibody fragments.
Cancer immunity 2001;1():2.
2001: Mikaël J Pittet; Daniel E Speiser; Danielle Liénard; Danila Valmori; Philippe Guillaume; Valérie Dutoit; Donata Rimoldi; Ferdy Lejeune; Jean-Charles Cerottini; Pedro Romero
Expansion and functional maturation of human tumor antigen-specific CD8+ T cells after vaccination with antigenic peptide.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(3 Suppl):796s-803s.
2001: Pedro Romero; Valérie Dutoit; Verena Rubio-Godoy; Danielle Liénard; Daniel Speiser; Philippe Guillaume; K Servis; Donata Rimoldi; Jean-Charles Cerottini; Danila Valmori
CD8+ T-cell response to NY-ESO-1: relative antigenicity and in vitro immunogenicity of natural and analogue sequences.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(3 Suppl):766s-772s.
2001: Pierre-Yves Dietrich; Paul R Walker; Anne-Lise Quiquerez; Gaëlle Perrin; Valérie Dutoit; Danielle Liénard; Philippe Guillaume; Jean-Charles Cerottini; Pedro Romero; Danila Valmori
Melanoma patients respond to a cytotoxic T lymphocyte-defined self-peptide with diverse and nonoverlapping T-cell receptor repertoires.
Cancer research 2001;61(5):2047-54.
2001: Daniel E Speiser; M Migliaccio; Mikaël J Pittet; Danila Valmori; Danielle Liénard; F Lejeune; Patrick Reichenbach; Philippe Guillaume; I Lüscher; Jean-Charles Cerottini; Pedro Romero
Human CD8(+) T cells expressing HLA-DR and CD28 show telomerase activity and are distinct from cytolytic effector T cells.
European journal of immunology 2001;31(2):459-66.
2001: M Berset; Jean-Philippe Cerottini; David Guggisberg; Pedro Romero; F Burri; Donata Rimoldi; Renato G Panizzon
Expression of Melan-A/MART-1 antigen as a prognostic factor in primary cutaneous melanoma.
International journal of cancer. Journal international du cancer 2001;95(1):73-7.
2001: Danila Valmori; Valérie Dutoit; Verena Rubio-Godoy; C Chambaz; Danielle Liénard; Philippe Guillaume; Pedro Romero; Jean-Charles Cerottini; Donata Rimoldi
Frequent cytolytic T-cell responses to peptide MAGE-A10(254-262) in melanoma.
Cancer research 2001;61(2):509-12.
2000: Donata Rimoldi; Verena Rubio-Godoy; Valérie Dutoit; Danielle Lienard; Suzanne Salvi; Philippe Guillaume; Daniel Speiser; E Stockert; G Spagnoli; Catherine Servis; Jean-Charles Cerottini; Ferdy Lejeune; Pedro Romero; Danila Valmori
Efficient simultaneous presentation of NY-ESO-1/LAGE-1 primary and nonprimary open reading frame-derived CTL epitopes in melanoma.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):7253-61.
2000: Pascale Jeannin; Toufic Renno; Liliane Goetsch; Isabelle Miconnet; Jean-Pierre Aubry; Yves Delneste; Nathalie Herbault; Thierry Baussant; Giovanni Magistrelli; Caroline Soulas; Pedro Romero; Jean-Charles Cerottini; Jean-Yves Bonnefoy
OmpA targets dendritic cells, induces their maturation and delivers antigen into the MHC class I presentation pathway.
Nature immunology 2000;1(6):502-9.
2000: Bruno Robert; Philippe Guillaume; Immanuel F Luescher; Pedro Romero; Jean-Pierre Mach
Antibody-conjugated MHC class I tetramers can target tumor cells for specific lysis by T lymphocytes.
European journal of immunology 2000;30(11):3165-70.
2000: Anilza Bonelo; Danila Valmori; F Triponez; Jean-Marie Tiercy; G Mentha; José Oberholzer; Patrick Champagne; Jackeline F Romero; Fulvio Esposito; Issa Nebié; Catherine Barbey; Pedro Romero; Sócrates Herrera; Giampietro Corradin; José Alejandro López
Generation and characterization of malaria-specific human CD8(+) lymphocyte clones: effect of natural polymorphism on T cell recognition and endogenous cognate antigen presentationby liver cells.
European journal of immunology 2000;30(11):3079-88.
2000: M Migliaccio; Mario Amacker; T Just; Patrick Reichenbach; Danila Valmori; Jean-Charles Cerottini; Pedro Romero; Markus Nabholz
Ectopic human telomerase catalytic subunit expression maintains telomere length but is not sufficient for CD8+ T lymphocyte immortalization.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(9):4978-84.
2000: John Mario González; Katrin Peter; Fulvio Esposito; Issa Nebié; Jean-Marie Tiercy; Anilza Bonelo; Myriam Arévalo-Herrera; Danila Valmori; Pedro Romero; John M Gonzalez; Giampietro Corradin; José Alejandro López
HLA-A*0201 restricted CD8+ T-lymphocyte responses to malaria: identification of new Plasmodium falciparum epitopes by IFN-gamma ELISPOT.
Parasite immunology 2000;22(10):501-14.
2000: Isabelle Miconnet; Catherine Servis; Jean-Charles Cerottini; Pedro Romero; Frédéric Lévy
Amino acid identity and/or position determines the proteasomal cleavage of the HLA-A*0201-restricted peptide tumor antigen MAGE-3271-279.
The Journal of biological chemistry 2000;275(35):26892-7.
2000: Danila Valmori; Valérie Dutoit; Danielle Liénard; Donata Rimoldi; Mikaël J Pittet; Patrick Champagne; Kim Ellefsen; U Sahin; Daniel Speiser; Ferdy Lejeune; Jean-Charles Cerottini; Pedro Romero
Naturally occurring human lymphocyte antigen-A2 restricted CD8+ T-cell response to the cancer testis antigen NY-ESO-1 in melanoma patients.
Cancer research 2000;60(16):4499-506.
2000: Danila Valmori; Valérie Dutoit; Danielle Liénard; Ferdy Lejeune; Daniel Speiser; Donata Rimoldi; Vincenzo Cerundolo; Pierre-Yves Dietrich; Jean-Charles Cerottini; Pedro Romero
Tetramer-guided analysis of TCR beta-chain usage reveals a large repertoire of melan-A-specific CD8+ T cells in melanoma patients.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(1):533-8.
2000: Nils Holler; Takao Kataoka; Jean-Luc Bodmer; Pedro Romero; J Romero; David Deperthes; J Engel; Jürg Tschopp; Pascal Schneider
Development of improved soluble inhibitors of FasL and CD40L based on oligomerized receptors.
Journal of immunological methods 2000;237(1-2):159-73.
2000: Mikaël J Pittet; Daniel E Speiser; Danila Valmori; Jean-Charles Cerottini; Pedro Romero
Cutting edge: cytolytic effector function in human circulating CD8+ T cells closely correlates with CD56 surface expression.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(3):1148-52.
2000: Danila Valmori; Frédéric Lévy; Isabelle Miconnet; Paul Zajac; Giulio C Spagnoli; Donata Rimoldi; Danielle Liénard; Vincenzo Cerundolo; Jean-Charles Cerottini; Pedro Romero
Induction of potent antitumor CTL responses by recombinant vaccinia encoding a melan-A peptide analogue.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(2):1125-31.
1999: Danila Valmori; Jean-François Fonteneau; Salvatore Valitutti; Nadine Gervois; R Dunbar; Danielle Liénard; Donata Rimoldi; Vincenzo Cerundolo; Francine Jotereau; Jean-Charles Cerottini; Daniel E Speiser; Pedro Romero
Optimal activation of tumor-reactive T cells by selected antigenic peptide analogues.
International immunology 1999;11(12):1971-80.
1999: Daniel E Speiser; Mikaël J Pittet; Danila Valmori; R Dunbar; Donata Rimoldi; Danielle Liénard; H Robson MacDonald; Jean-Charles Cerottini; Vincenzo Cerundolo; Pedro Romero
In vivo expression of natural killer cell inhibitory receptors by human melanoma-specific cytolytic T lymphocytes.
The Journal of experimental medicine 1999;190(6):775-82.
1999: Mikaël J Pittet; Danila Valmori; P R Dunbar; Daniel E Speiser; Danielle Liénard; Ferdy Lejeune; Katharina Fleischhauer; Vincenzo Cerundolo; Jean-Charles Cerottini; Pedro Romero
High frequencies of naive Melan-A/MART-1-specific CD8(+) T cells in a large proportion of human histocompatibility leukocyte antigen (HLA)-A2 individuals.
The Journal of experimental medicine 1999;190(5):705-15.
1999: Danila Valmori; Mikaël J Pittet; C Vonarbourg; Donata Rimoldi; Danielle Liénard; Daniel Speiser; R Dunbar; Vincenzo Cerundolo; Jean-Charles Cerottini; Pedro Romero
Analysis of the cytolytic T lymphocyte response of melanoma patients to the naturally HLA-A*0201-associated tyrosinase peptide 368-376.
Cancer research 1999;59(16):4050-5.
1999: Pascal Schneider; Fabienne Mackay; V Steiner; Kay Hofmann; Jean-Luc Bodmer; Nils Holler; Christine Ambrose; P Lawton; Sarah A Bixler; Hans Acha-Orbea; Danila Valmori; Pedro Romero; Christiane Werner-Favre; Rudolf H Zubler; Jeffrey L Browning; Jürg Tschopp
BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth.
The Journal of experimental medicine 1999;189(11):1747-56.
1999: Katharina Fleischhauer; A Agostino; Elisabetta Zino; Benedetta Mazzi; E Benazzi; Myriam Arevalo-Herrera; Sócrates Herrera; Claudio Bordignon; Pedro Romero
Molecular characterization of HLA class I in Colombians carrying HLA-A2: high allelic diversity and frequency of heterozygotes at the HLA-B locus.
Tissue antigens 1999;53(6):519-26.
1999: Daniel E Speiser; Danila Valmori; Donata Rimoldi; Mikaël J Pittet; Danielle Liénard; Vincenzo Cerundolo; H Robson MacDonald; Jean-Charles Cerottini; Pedro Romero
CD28-negative cytolytic effector T cells frequently express NK receptors and are present at variable proportions in circulating lymphocytes from healthy donors and melanoma patients.
European journal of immunology 1999;29(6):1990-9.
1999: Danila Valmori; Mikaël J Pittet; Donata Rimoldi; Danielle Liénard; R Dunbar; Vincenzo Cerundolo; Ferdy Lejeune; Jean-Charles Cerottini; Pedro Romero
An antigen-targeted approach to adoptive transfer therapy of cancer.
Cancer research 1999;59(9):2167-73.
1999: Ying Men; Isabelle Miconnet; Danila Valmori; Donata Rimoldi; Jean-Charles Cerottini; Pedro Romero
Assessment of immunogenicity of human Melan-A peptide analogues in HLA-A*0201/Kb transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(6):3566-73.
1999: Danila Valmori; Uzi Gileadi; Catherine Servis; P Rod Dunbar; Jean-Charles Cerottini; Pedro Romero; Vincenzo Cerundolo; Frédéric Lévy
Modulation of proteasomal activity required for the generation of a cytotoxic T lymphocyte-defined peptide derived from the tumor antigen MAGE-3.
The Journal of experimental medicine 1999;189(6):895-906.
1998: Danila Valmori; Nadine Gervois; Donata Rimoldi; Jean-François Fonteneau; Anilza Bonelo; Danielle Liénard; L Rivoltini; Francine Jotereau; Jean-Charles Cerottini; Pedro Romero
Diversity of the fine specificity displayed by HLA-A*0201-restricted CTL specific for the immunodominant Melan-A/MART-1 antigenic peptide.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(12):6956-62.
1998: Pedro Romero; P R Dunbar; Danila Valmori; Mikaël J Pittet; G S Ogg; Donata Rimoldi; J L Chen; Danielle Liénard; Jean-Charles Cerottini; Vincenzo Cerundolo
Ex vivo staining of metastatic lymph nodes by class I major histocompatibility complex tetramers reveals high numbers of antigen-experienced tumor-specific cytolytic T lymphocytes.
The Journal of experimental medicine 1998;188(9):1641-50.
1998: Danila Valmori; Jean-François Fonteneau; C M Lizana; Nadine Gervois; Danielle Liénard; Donata Rimoldi; Victor Jongeneel; Francine Jotereau; Jean-Charles Cerottini; Pedro Romero
Enhanced generation of specific tumor-reactive CTL in vitro by selected Melan-A/MART-1 immunodominant peptide analogues.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(4):1750-8.
1998: Katharina Fleischhauer; Elisabetta Zino; Myriam Arevalo-Herrera; Sócrates Herrera; Danila Valmori; Jean-Charles Cerottini; E Benazzi; Claudio Bordignon; Pedro Romero
Differential expression of HLA-A*02 subtypes in Colombian Blacks and Mestizos.
Tissue antigens 1998;51(2):204-9.
1998: Jean-Charles Cerottini; Danila Valmori; Donata Rimoldi; Pedro Romero
Human tumor immunotherapy. New opportunities as well as new challenges.
Advances in experimental medicine and biology 1998;451():247-50.
1997: D S Reed; Pedro Romero; Donata Rimoldi; Jean-Charles Cerottini; J Schaack; Victor Jongeneel
Construction and characterization of a recombinant adenovirus directing expression of the MAGE-1 tumor-specific antigen.
International journal of cancer. Journal international du cancer 1997;72(6):1045-55.
1997: Pedro Romero; Nadine Gervois; Joerg Schneider; P Escobar; Danila Valmori; C Pannetier; A Steinle; T Wolfel; Danielle Lienard; Vincent G Brichard; Aline Van Pel; Francine Jotereau; Jean-Charles Cerottini
Cytolytic T lymphocyte recognition of the immunodominant HLA-A*0201-restricted Melan-A/MART-1 antigenic peptide in melanoma.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(5):2366-74.
1997: G A Waanders; Donata Rimoldi; Danielle Liénard; S Carrel; Ferdy Lejeune; P Y Dietrich; Jean-Charles Cerottini; Pedro Romero
Melanoma-reactive human cytotoxic T lymphocytes derived from skin biopsies of delayed-type hypersensitivity reactions induced by injection of an autologous melanoma cell line.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(5):685-96.
1997: Fabienne Anjuère; Dmitry Kuznetsov; Pedro Romero; Jean-Charles Cerottini; Victor Jongeneel; Immanuel F Luescher
Differential roles of T cell receptor alpha and beta chains in ligand binding among H-2Kd-restricted cytolytic T lymphocyte clones specific for a photoreactive Plasmodium berghei circumsporozoite peptide derivative.
The Journal of biological chemistry 1997;272(13):8505-14.
1997: Danila Valmori; Danielle Liénard; G Waanders; Donata Rimoldi; Jean-Charles Cerottini; Pedro Romero
Analysis of MAGE-3-specific cytolytic T lymphocytes in human leukocyte antigen-A2 melanoma patients.
Cancer research 1997;57(4):735-41.
1996: Michael Hahne; Donata Rimoldi; M Schröter; Pedro Romero; M Schreier; Lars E French; Pascal Schneider; T Bornand; A Fontana; D Lienard; Jean-Charles Cerottini; Jürg Tschopp
Melanoma cell expression of Fas(Apo-1/CD95) ligand: implications for tumor immune escape.
Science (New York, N.Y.) 1996;274(5291):1363-6.
1996: Immanuel F Luescher; Pedro Romero; D Kuznetsov; Donata Rimoldi; Pierre G Coulie; Jean-Charles Cerottini; Victor Jongeneel
HLA photoaffinity labeling reveals overlapping binding of homologous melanoma-associated gene peptides by HLA-A1, HLA-A29, and HLA-B44.
The Journal of biological chemistry 1996;271(21):12463-71.
1996: J Herman; Pierre van der Bruggen; I F Luescher; S Mandruzzato; Pedro Romero; Joëlle Thonnard; Katharina Fleischhauer; Thierry Boon; Pierre G Coulie
A peptide encoded by the human MAGE3 gene and presented by HLA-B44 induces cytolytic T lymphocytes that recognize tumor cells expressing MAGE3.
Immunogenetics 1996;43(6):377-83.
1995: Pedro Romero; C Pannetier; J Herman; Victor Jongeneel; Jean-Charles Cerottini; Pierre G Coulie
Multiple specificities in the repertoire of a melanoma patient's cytolytic T lymphocytes directed against tumor antigen MAGE-1.A1.
The Journal of experimental medicine 1995;182(4):1019-28.
1995: Immanuel F Luescher; Fabienne Anjuère; Manuel Peitsch; Victor Jongeneel; Jean-Charles Cerottini; Pedro Romero
Structural analysis of TCR-ligand interactions studied on H-2Kd-restricted cloned CTL specific for a photoreactive peptide derivative.
Immunity 1995;3(1):51-63.
1995: J Renggli; Danila Valmori; J F Romero; G Eberl; Pedro Romero; B Betschart; Giampietro Corradin
CD8+ T-cell protective immunity induced by immunization with Plasmodium berghei CS protein-derived synthetic peptides: evidence that localization of peptide-specific CTLs is crucial for protection against malaria.
Immunology letters 1995;46(1-2):199-205.
1995: Immanuel F Luescher; Eric Vivier; A Layer; J Mahiou; F Godeau; Bernard Malissen; Pedro Romero
CD8 modulation of T-cell antigen receptor-ligand interactions on living cytotoxic T lymphocytes.
Nature 1995;373(6512):353-6.
1994: F da Conceição-Silva; B L Perlaza; Jacques A Louis; Pedro Romero
Leishmania major infection in mice primes for specific major histocompatibility complex class I-restricted CD8+ cytotoxic T cell responses.
European journal of immunology 1994;24(11):2813-7.
1994: Danila Valmori; J F Romero; Ying Men; J L Maryanski; Pedro Romero; Giampietro Corradin
Induction of a cytotoxic T cell response by co-injection of a T helper peptide and a cytotoxic T lymphocyte peptide in incomplete Freund's adjuvant (IFA): further enhancement by pre-injection of IFA alone.
European journal of immunology 1994;24(6):1458-62.
1994: Pedro Romero; Jean-Charles Cerottini; Immanuel F Luescher
Efficient in vivo induction of CTL by cell-associated covalent H-2Kd-peptide complexes.
Journal of immunological methods 1994;171(1):73-84.
1993: G Eberl; A Sabbatini; Catherine Servis; Pedro Romero; J L Maryanski; Giampietro Corradin
MHC class I H-2Kd-restricted antigenic peptides: additional constraints for the binding motif.
International immunology 1993;5(11):1489-92.
1993: Pedro Romero; J L Maryanski; Immanuel F Luescher
Photoaffinity labeling of the T cell receptor on living cytotoxic T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(9):3825-31.
1993: J L Maryanski; R Lüthy; Pedro Romero; F Healy; C Drouet; Jean-Laurent Casanova; C Jaulin; Philippe Kourilsky; Giampietro Corradin
The interaction of antigenic peptides with the H-2Kd MHC class I molecule.
Seminars in immunology 1993;5(2):95-104.
1992: C Jaulin; Jean-Laurent Casanova; Pedro Romero; Immanuel F Luescher; A S Cordey; J L Maryanski; Philippe Kourilsky
Highly diverse T cell recognition of a single Plasmodium berghei peptide presented by a series of mutant H-2Kd molecules.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(12):3990-4.
1992: C Widmann; Pedro Romero; J L Maryanski; Giampietro Corradin; Danila Valmori
T helper epitopes enhance the cytotoxic response of mice immunized with MHC class I-restricted malaria peptides.
Journal of immunological methods 1992;155(1):95-9.
1992: C Jaulin; Pedro Romero; Immanuel F Luescher; Jean-Laurent Casanova; Ada Prochnicka-Chalufour; Pierre Langlade-Demoyen; J L Maryanski; Philippe Kourilsky
Most residues on the floor of the antigen binding site of the class I MHC molecule H-2Kd influence peptide presentation.
International immunology 1992;4(8):945-53.
1992: M Rodrigues; Ruth S Nussenzweig; Pedro Romero; Fidel Zavala
The in vivo cytotoxic activity of CD8+ T cell clones correlates with their levels of expression of adhesion molecules.
The Journal of experimental medicine 1992;175(4):895-905.
1992: Pedro Romero; G Eberl; Jean-Laurent Casanova; A S Cordey; C Widmann; Immanuel F Luescher; Giampietro Corradin; J L Maryanski
Immunization with synthetic peptides containing a defined malaria epitope induces a highly diverse cytotoxic T lymphocyte response. Evidence that two peptide residues are buried in the MHC molecule.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(6):1871-8.
1991: C Widmann; J L Maryanski; Pedro Romero; Giampietro Corradin
Differential stability of antigenic MHC class I-restricted synthetic peptides.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(11):3745-51.
1991: Jean-Laurent Casanova; Pedro Romero; C Widmann; Philippe Kourilsky; J L Maryanski
T cell receptor genes in a series of class I major histocompatibility complex-restricted cytotoxic T lymphocyte clones specific for a Plasmodium berghei nonapeptide: implications for T cell allelic exclusion and antigen-specific repertoire.
The Journal of experimental medicine 1991;174(6):1371-83.
1991: F Healy; C Drouet; Pedro Romero; C Jaulin; J L Maryanski
Conversion of a self peptide sequence into a Kd-restricted neo-antigen by a Tyr substitution.
The Journal of experimental medicine 1991;174(6):1657-60.
1991: J L Maryanski; Pedro Romero; Aline Van Pel; T Boon; Francis Salemme; Jean-Charles Cerottini; Giampietro Corradin
The identification of tyrosine as a common key residue in unrelated H-2Kd restricted antigenic peptides.
International immunology 1991;3(10):1035-42.
1991: Pedro Romero; Giampietro Corradin; Immanuel F Luescher; J L Maryanski
H-2Kd-restricted antigenic peptides share a simple binding motif.
The Journal of experimental medicine 1991;174(3):603-12.
1991: M M Rodrigues; A S Cordey; G Arreaza; Giampietro Corradin; Pedro Romero; J L Maryanski; Ruth S Nussenzweig; Fidel Zavala
CD8+ cytolytic T cell clones derived against the Plasmodium yoelii circumsporozoite protein protect against malaria.
International immunology 1991;3(6):579-85.
1991: Immanuel F Luescher; Pedro Romero; Jean-Charles Cerottini; J L Maryanski
Specific binding of antigenic peptides to cell-associated MHC class I molecules.
Nature 1991;351(6321):72-4.
1991: Thomas Herrmann; Pedro Romero; Silvia Sartoris; F Paiola; Roberto Accolla; J L Maryanski; H Robson MacDonald
Staphylococcal enterotoxin-dependent lysis of MHC class II negative target cells by cytolytic T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(8):2504-12.
1990: Moriya Tsuji; Pedro Romero; Ruth S Nussenzweig; Fidel Zavala
CD4+ cytolytic T cell clone confers protection against murine malaria.
The Journal of experimental medicine 1990;172(5):1353-7.
1990: Pedro Romero; J L Maryanski; A S Cordey; Giampietro Corradin; Ruth S Nussenzweig; Fidel Zavala
Isolation and characterization of protective cytolytic T cells in a rodent malaria model system.
Immunology letters 1990;25(1-3):27-31.
1990: Thomas Herrmann; J L Maryanski; Pedro Romero; B Fleischer; H Robson MacDonald
Activation of MHC class I-restricted CD8+ CTL by microbial T cell mitogens. Dependence upon MHC class II expression of the target cells and V beta usage of the responder T cells.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(4):1181-6.
1989: Pedro Romero; J L Maryanski; Giampietro Corradin; Ruth S Nussenzweig; Victor Nussenzweig; Fidel Zavala
Cloned cytotoxic T cells recognize an epitope in the circumsporozoite protein and protect against malaria.
Nature 1989;341(6240):323-6.