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Cynthia Rominger

Research Profile

Chemicals & Drugs

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Tumor Cell Line

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Publications

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Robert M Sanchez; Michael D Schaber; Michael D Spengler; Rosanna Tedesco; Hongyi Yu; Cynthia M Rominger; Karl Erhard; Mary Ann Hardwicke; Hong Lin; Juan I Luengo; Jeanelle McSurdy-Freed; Michael L Moore; Ramona Plant; Kaushik Raha; Ralph A Rivero
Synthesis and structure-activity relationships of 1,2,4-triazolo[1,5-a]pyrimidin-7(3H)-ones as novel series of potent β isoform selective phosphatidylinositol 3-kinase inhibitors.
Hong Lin; Juan I Luengo; James F Mack; Jeanelle McSurdy-Freed; Ramona Plant; Kaushik Raha; Karl Erhard; Mary Ann Hardwicke; Cynthia M Rominger; Robert M Sanchez; Michael D Schaber; Mark J Schulz; Michael D Spengler; Rosanna Tedesco; Ren Xie; Jin J Zeng; Ralph A Rivero
Synthesis and structure-activity relationships of imidazo[1,2-a]pyrimidin-5(1H)-ones as a novel series of beta isoform selective phosphatidylinositol 3-kinase inhibitors.
Cynthia M Rominger; Michael D Schaber; Jingsong Yang; Richard R Gontarek; Kurt L Weaver; Timothy Broderick; Luke Carter; Robert Copeland; Earl W May
An intrinsic ATPase activity of phospho-MEK-1 uncoupled from downstream ERK phosphorylation.

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All Publications

2012: Robert M Sanchez; Michael D Schaber; Michael D Spengler; Rosanna Tedesco; Hongyi Yu; Cynthia M Rominger; Karl Erhard; Mary Ann Hardwicke; Hong Lin; Juan I Luengo; Jeanelle McSurdy-Freed; Michael L Moore; Ramona Plant; Kaushik Raha; Ralph A Rivero
Synthesis and structure-activity relationships of 1,2,4-triazolo[1,5-a]pyrimidin-7(3H)-ones as novel series of potent β isoform selective phosphatidylinositol 3-kinase inhibitors.
Bioorganic & medicinal chemistry letters 2012;22(9):3198-202.
2012: Hong Lin; Juan I Luengo; James F Mack; Jeanelle McSurdy-Freed; Ramona Plant; Kaushik Raha; Karl Erhard; Mary Ann Hardwicke; Cynthia M Rominger; Robert M Sanchez; Michael D Schaber; Mark J Schulz; Michael D Spengler; Rosanna Tedesco; Ren Xie; Jin J Zeng; Ralph A Rivero
Synthesis and structure-activity relationships of imidazo[1,2-a]pyrimidin-5(1H)-ones as a novel series of beta isoform selective phosphatidylinositol 3-kinase inhibitors.
Bioorganic & medicinal chemistry letters 2012;22(6):2230-4.
2007: Cynthia M Rominger; Michael D Schaber; Jingsong Yang; Richard R Gontarek; Kurt L Weaver; Timothy Broderick; Luke Carter; Robert Copeland; Earl W May
An intrinsic ATPase activity of phospho-MEK-1 uncoupled from downstream ERK phosphorylation.
Archives of biochemistry and biophysics 2007;464(1):130-7.
2006: Alastair J King; Denis R Patrick; Roberta S Batorsky; Maureen L Ho; Hieu T Do; Shu Yun Zhang; Rakesh Kumar; David W Rusnak; Andrew K Takle; David M Wilson; Erin Hugger; Lifu Wang; Florian Karreth; Julie C Lougheed; Jae Lee; David Chau; Thomas Stout; Earl W May; Cynthia M Rominger; Michael D Schaber; Lusong Luo; Ami S Lakdawala; Jerry L Adams; Rooha Contractor; Keiran Smalley; Meenhard Herlyn; Michael M Morrissey; David A Tuveson; Pearl S Huang
Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885.
Cancer research 2006;66(23):11100-5.
2004: Xiao-Xin Yan; Tong Li; Cynthia M Rominger; Shimoga R Prakash; Philip C Wong; Richard E Olson; Robert Zaczek; Yu-Wen Li
Binding sites of gamma-secretase inhibitors in rodent brain: distribution, postnatal development, and effect of deafferentation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(12):2942-52.
2003: Ge Zhang; Ning Huang; Yu-Wen Li; Xiaoping Qi; Anne P Marshall; Xiao-Xin Yan; Geraldine Hill; Cynthia M Rominger; Shimoga R Prakash; Rajagopal Bakthavatchalam; David H Rominger; Paul J Gilligan; Robert Zaczek
Pharmacological characterization of a novel nonpeptide antagonist radioligand, (+/-)-N-[2-methyl-4-methoxyphenyl]-1-(1-(methoxymethyl) propyl)-6-methyl-1H-1,2,3-triazolo[4,5-c]pyridin-4-amine ([3H]SN003) for corticotropin-releasing factor1 receptors.
The Journal of pharmacology and experimental therapeutics 2003;305(1):57-69.
2000: Dietmar Seiffert; Jodi D Bradley; Cynthia M Rominger; David H Rominger; F Yang; Jere E Meredith; Qian Wang; Arthur H Roach; Lorin A Thompson; Susan M Spitz; Jeffrey N Higaki; Shimoga R Prakash; Andrew P Combs; Robert Copeland; Stephen P Arneric; Paul R Hartig; David W Robertson; Barbara Cordell; Andrew M Stern; Richard E Olson; Robert Zaczek
Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors.
The Journal of biological chemistry 2000;275(44):34086-91.
1998: David H Rominger; Cynthia M Rominger; Lawrence W Fitzgerald; Reinhard Grzanna; Brian L Largent; Robert Zaczek
Characterization of [125I]sauvagine binding to CRH2 receptors: membrane homogenate and autoradiographic studies.
The Journal of pharmacology and experimental therapeutics 1998;286(1):459-68.