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Maria-Grazia Roncarolo

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Samantha Scaramuzza; Manfred Schmidt; Elisa Vicenzi; Anna Villa; Christof von Kalle; Cynthia C Bartholomae; Fabrizio Benedicenti; Luca Biasco; Alessandra Biffi; Marita Bosticardo; Robbert Bredius; Maria C Castiello; Elena Draghici; Andrea Finocchi; Raisa J Hernandez; Mariana Loperfido; Eugenio Montini; Luigi Naldini; Marina Radrizzani; Marco Ranzani; Anna Ripamonti; Maria-Grazia Roncarolo; Monica Salomoni; Alessandro Aiuti
Preclinical safety and efficacy of human CD34(+) cells transduced with lentiviral vector for the treatment of Wiskott-Aldrich syndrome.
M Catucci; Elena Draghici; M Locci; F Prete; Maria-Grazia Roncarolo; Alessandro Aiuti; F Benvenuti; M Bosticardo; M C Castiello; Anna Villa
Dendritic cell functional improvement in a preclinical model of lentiviral-mediated gene therapy for Wiskott-Aldrich syndrome.
Grazia Andolfi; Attilio Bondanza; Georgia Fousteri; Silvia Gregori; Tatiana Jofra; Grazia Locafaro; Chiara F Magnani; Maura Rossetti; Maria-Grazia Roncarolo
Enforced IL-10 expression confers type 1 regulatory T cell (Tr1) phenotype and function to human CD4(+) T cells.

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All Publications

2013: Samantha Scaramuzza; Manfred Schmidt; Elisa Vicenzi; Anna Villa; Christof von Kalle; Cynthia C Bartholomae; Fabrizio Benedicenti; Luca Biasco; Alessandra Biffi; Marita Bosticardo; Robbert Bredius; Maria C Castiello; Elena Draghici; Andrea Finocchi; Raisa J Hernandez; Mariana Loperfido; Eugenio Montini; Luigi Naldini; Marina Radrizzani; Marco Ranzani; Anna Ripamonti; Maria-Grazia Roncarolo; Monica Salomoni; Alessandro Aiuti
Preclinical safety and efficacy of human CD34(+) cells transduced with lentiviral vector for the treatment of Wiskott-Aldrich syndrome.
Molecular therapy : the journal of the American Society of Gene Therapy 2013;21(1):175-84.
2012: M Catucci; Elena Draghici; M Locci; F Prete; Maria-Grazia Roncarolo; Alessandro Aiuti; F Benvenuti; M Bosticardo; M C Castiello; Anna Villa
Dendritic cell functional improvement in a preclinical model of lentiviral-mediated gene therapy for Wiskott-Aldrich syndrome.
Gene therapy 2012;19(12):1150-8.
2012: Grazia Andolfi; Attilio Bondanza; Georgia Fousteri; Silvia Gregori; Tatiana Jofra; Grazia Locafaro; Chiara F Magnani; Maura Rossetti; Maria-Grazia Roncarolo
Enforced IL-10 expression confers type 1 regulatory T cell (Tr1) phenotype and function to human CD4(+) T cells.
Molecular therapy : the journal of the American Society of Gene Therapy 2012;20(9):1778-90.
2012: Federico Sizzano; Pietro Sodani; M Testi; M Torchio; M Troiano; G Turchiano; L Zito; Antonio Amoroso; Marco Andreani; R Chiesa; Fabio Ciceri; Roberto Crocchiolo; Javid Gaziev; Silvia Gregori; G Lucarelli; Sarah Marktel; Benedetta Mazzi; C Pultrone; Maria-Grazia Roncarolo; Katharina Fleischhauer
Genotypes and haplotypes in the 3' untranslated region of the HLA-G gene and their association with clinical outcome of hematopoietic stem cell transplantation for beta-thalassemia.
Tissue antigens 2012;79(5):326-32.
2012: Aisha V Sauer; Samantha Scaramuzza; Antonella Tabucchi; Elisabetta Traggiai; Anna Villa; Raisa Jofra Hernandez; Immacolata Brigida; Filippo Carlucci; Nicola Carriglio; Daniela Clavenna; Nicola Gagliani; Pietro Luigi Poliani; Maria-Grazia Roncarolo; Francesca Sanvito; Alessandro Aiuti
Alterations in the adenosine metabolism and CD39/CD73 adenosinergic machinery cause loss of Treg cell function and autoimmunity in ADA-deficient SCID.
Blood 2012;119(6):1428-39.
2012: F Barzaghi; Caterina Cancrini; M Cecconi; Y H Choe; R Ciccocioppo; S Ciullini Mannurita; T Cornu; S Corrente; V Discepolo; Eleonora Gambineri; A Ikinciogullari; E S Kang; S Olek; Laura Passerini; Maria-Grazia Roncarolo; Claudia Sartirana; J Schmidtko; G Zuin; alessandro ambrosi; Rosa Bacchetta
Demethylation analysis of the FOXP3 locus shows quantitative defects of regulatory T cells in IPEX-like syndrome.
Journal of autoimmunity 2012;38(1):49-58.
2011: Marita Bosticardo; Elena Draghici; Francesca Schena; Aisha Vanessa Sauer; Elena Fontana; Maria Carmina Castiello; Marco Catucci; Michela Locci; Luigi Naldini; Alessandro Aiuti; Maria-Grazia Roncarolo; Pietro Luigi Poliani; Elisabetta Traggiai; Anna Villa
Lentiviral-mediated gene therapy leads to improvement of B-cell functionality in a murine model of Wiskott-Aldrich syndrome.
The Journal of allergy and clinical immunology 2011;127(6):1376-84.e5.
2011: Maria-Grazia Roncarolo; Silvia Gregori; Barbarella Lucarelli; Fabio Ciceri; Rosa Bacchetta
Clinical tolerance in allogeneic hematopoietic stem cell transplantation.
Immunological reviews 2011;241(1):145-63.
2011: Laura Passerini; Sara Di Nunzio; Silvia Gregori; Eleonora Gambineri; Massimiliano Cecconi; Markus G Seidel; Giantonio Cazzola; Lucia Perroni; Alberto Tommasini; Silvia Vignola; Luisa Guidi; Maria-Grazia Roncarolo; Rosa Bacchetta
Functional type 1 regulatory T cells develop regardless of FOXP3 mutations in patients with IPEX syndrome.
European journal of immunology 2011;41(4):1120-31.
2011: Maura Rossetti; Silvia Gregori; Ehud Hauben; Brian D Brown; Lucia Sergi Sergi; Luigi Naldini; Maria-Grazia Roncarolo
HIV-1-derived lentiviral vectors directly activate plasmacytoid dendritic cells, which in turn induce the maturation of myeloid dendritic cells.
Human gene therapy 2011;22(2):177-88.
2011: Kevin Scott Goudy; Luigi Naldini; Andrea Annoni; Maria-Grazia Roncarolo
Manipulating Immune Tolerance with Micro-RNA Regulated Gene Therapy.
Frontiers in microbiology 2011;2():221.
2010: Alicia N McMurchy; Jana Gillies; Sarah E Allan; Laura Passerini; Eleonora Gambineri; Maria-Grazia Roncarolo; Rosa Bacchetta; Megan K Levings
Point mutants of forkhead box P3 that cause immune dysregulation, polyendocrinopathy, enteropathy, X-linked have diverse abilities to reprogram T cells into regulatory T cells.
The Journal of allergy and clinical immunology 2010;126(6):1242-51.
2010: Rosa Bacchetta; Silvia Gregori; Giorgia Serafini; Claudia Sartirana; Ute Schulz; Elisabetta Zino; Stefan Tomiuk; Uwe Jansen; Maurilio Ponzoni; Carlo Terenzio Paties; Katharina Fleischhauer; Maria-Grazia Roncarolo
Molecular and functional characterization of allogantigen-specific anergic T cells suitable for cell therapy.
Haematologica 2010;95(12):2134-43.
2010: Silvia Gregori; Daniela Tomasoni; Valentina Pacciani; Miriam Scirpoli; Manuela Battaglia; Chiara Francesca Magnani; Ehud Hauben; Maria-Grazia Roncarolo
Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway.
Blood 2010;116(6):935-44.
2010: I Frugnoli; B Cappelli; Roberto Chiesa; E Biral; A Noè; C Evangelio; M Fossati; S Napolitano; Fabio Ciceri; Maria-Grazia Roncarolo; Sarah Marktel
Escalating doses of donor lymphocytes for incipient graft rejection following SCT for thalassemia.
Bone marrow transplantation 2010;45(6):1047-51.
2010: Sara Trifari; Samantha Scaramuzza; Marco Catucci; Maurilio Ponzoni; Luca Mollica; Robert Chiesa; Federica Cattaneo; Fanny Lafouresse; Ronan Calvez; william vermi; Daniela Medicina; Maria Carmina Castiello; Francesco Marangoni; Marita Bosticardo; Claudio Doglioni; Maurizio Caniglia; Alessandro Aiuti; Anna Villa; Maria-Grazia Roncarolo; Loïc Dupré
Revertant T lymphocytes in a patient with Wiskott-Aldrich syndrome: analysis of function and distribution in lymphoid organs.
The Journal of allergy and clinical immunology 2010;125(2):439-448.e8.
2009: Andrea Annoni; Brian D Brown; Alessio Cantore; Lucia Sergi Sergi; Luigi Naldini; Maria-Grazia Roncarolo
In vivo delivery of a microRNA-regulated transgene induces antigen-specific regulatory T cells and promotes immunologic tolerance.
Blood 2009;114(25):5152-61.
2009: Nicola Gagliani; Alessandra Ferraro; Maria-Grazia Roncarolo; Manuela Battaglia
Autoimmune diabetic patients undergoing allogeneic islet transplantation: are we ready for a regulatory T-cell therapy?
Immunology letters 2009;127(1):1-7.
2009: Silvia Gregori; Chiara Francesca Magnani; Maria-Grazia Roncarolo
Role of human leukocyte antigen-G in the induction of adaptive type 1 regulatory T cells.
Human immunology 2009;70(12):966-9.
2009: Sara Di Nunzio; Massimiliano Cecconi; Laura Passerini; Alicia N McMurchy; Udo Baron; Ivana Turbachova; Silvia Vignola; Erica Valencic; Alberto Tommasini; Anne Junker; Giantonio Cazzola; Sven Olek; Megan K Levings; Lucia Perroni; Maria-Grazia Roncarolo; Rosa Bacchetta
Wild-type FOXP3 is selectively active in CD4+CD25(hi) regulatory T cells of healthy female carriers of different FOXP3 mutations.
Blood 2009;114(19):4138-41.
2009: Barbara Cappelli; Robert Chiesa; Costanza Evangelio; Alessandra Biffi; Tito Roccia; Ilaria Frugnoli; Erika Biral; Anna Noè; Marco Fossati; Valentina Finizio; Roberto Miniero; Sara Napolitano; Francesca Ferrua; Clara Soliman; Fabio Ciceri; Maria-Grazia Roncarolo; Sarah Marktel
Absence of VOD in paediatric thalassaemic HSCT recipients using defibrotide prophylaxis and intravenous Busulphan.
British journal of haematology 2009;147(4):554-60.
2009: Barbara Cassani; Enrica Montini; giulietta maruggi; alessandro ambrosi; Massimiliano Mirolo; Silvia Selleri; Erika Biral; Ilaria Frugnoli; Vivian Hernandez-Trujillo; Clelia Di Serio; Maria-Grazia Roncarolo; Luigi Naldini; Fulvio Mavilio; Alessandro Aiuti
Integration of retroviral vectors induces minor changes in the transcriptional activity of T cells from ADA-SCID patients treated with gene therapy.
Blood 2009;114(17):3546-56.
2009: Aisha V Sauer; Emanuela Mrak; Raisa Jofra Hernandez; Elena Zacchi; Francesco Cavani; Monica Casiraghi; Eyal Grunebaum; Chaim M Roifman; Maria C Cervi; alessandro ambrosi; Filippo Carlucci; Maria-Grazia Roncarolo; Anna Villa; Alessandro Rubinacci; Alessandro Aiuti
ADA-deficient SCID is associated with a specific microenvironment and bone phenotype characterized by RANKL/OPG imbalance and osteoblast insufficiency.
Blood 2009;114(15):3216-26.
2009: Giorgia Serafini; Marco Andreani; M Testi; MariaRosa Battarra; Andrea Bontadini; Eika Biral; Katharina Fleischhauer; Sarah Marktel; Guido Lucarelli; Maria-Grazia Roncarolo; Rosa Bacchetta
Type 1 regulatory T cells are associated with persistent split erythroid/lymphoid chimerism after allogeneic hematopoietic stem cell transplantation for thalassemia.
Haematologica 2009;94(10):1415-26.
2009: Martina Cesani; Alessia Capotondo; Tiziana Plati; Lucia Sergi Sergi; Francesca Fumagalli; Maria-Grazia Roncarolo; Luigi Naldini; Giancarlo Comi; Maria Sessa; Alessandra Biffi
Characterization of new arylsulfatase A gene mutations reinforces genotype-phenotype correlation in metachromatic leukodystrophy.
Human mutation 2009;30(10):E936-45.
2009: Luca Vago; Serena Kimi Perna; Monica Zanussi; Benedetta Mazzi; Cristina Barlassina; Maria Teresa Lupo Stanghellini; Nicola Flavio Perrelli; Cristian Cosentino; Federica Torri; Andrea Angius; Barbara Forno; Monica Casucci; Massimo Bernardi; Jacopo Peccatori; Consuelo Corti; Attilio Bondanza; Maurizio Ferrari; silvano rossini; Maria-Grazia Roncarolo; Claudio Bordignon; Chiara Bonini; Fabio Ciceri; Katharina Fleischhauer
Loss of mismatched HLA in leukemia after stem-cell transplantation.
The New England journal of medicine 2009;361(5):478-88.
2009: Francesco Marangoni; Marita Bosticardo; Sabine Charrier; Elena Draghici; Michela Locci; Samantha Scaramuzza; Cristina Panaroni; Maurilio Ponzoni; Francesca Sanvito; Claudio Doglioni; Marie Liabeuf; Bernard Gjata; Marie Montus; Katherine Siminovitch; Alessandro Aiuti; Luigi Naldini; Loic DUPRE; Maria-Grazia Roncarolo; Anne Galy; Anna Villa
Evidence for long-term efficacy and safety of gene therapy for Wiskott-Aldrich syndrome in preclinical models.
Molecular therapy : the journal of the American Society of Gene Therapy 2009;17(6):1073-82.
2009: Alessandro Aiuti; Federica Cattaneo; Stefania Galimberti; Ulrike Benninghoff; Barbara Cassani; Luciano Callegaro; Samantha Scaramuzza; Grazia Andolfi; Massimiliano Mirolo; Immacolata Brigida; Antonella Tabucchi; Filippo Carlucci; Martha Eibl; Memet Aker; Shimon Slavin; Hamoud Al-Mousa; Abdulaziz Al-Ghonaium; Alina Ferster; Andrea Duppenthaler; Luigi Notarangelo; Uwe Wintergerst; Rebecca H Buckley; Marco Bregni; Sarah Marktel; Maria Grazia Valsecchi; Paolo Rossi; Fabio Ciceri; Roberto Miniero; Claudio Bordignon; Maria-Grazia Roncarolo
Gene therapy for immunodeficiency due to adenosine deaminase deficiency.
The New England journal of medicine 2009;360(5):447-58.
2009: Alessandro Aiuti; Immacolata Brigida; Francesca Ferrua; Barbara Cappelli; Robert Chiesa; Sarah Marktel; Maria-Grazia Roncarolo
Hematopoietic stem cell gene therapy for adenosine deaminase deficient-SCID.
Immunologic research 2009;44(1-3):150-9.
2008: Luca Vago; Barbara Forno; Maria Pia Sormani; Roberto Crocchiolo; Elisabetta Zino; Simona Di Terlizzi; Maria Teresa Lupo Stanghellini; Benedetta Mazzi; Serena K Perna; Attilio Bondanza; DEREK MIDDLETON; Alessio Palini; Massimo Bernardi; Rosa Bacchetta; Jacopo Peccatori; silvano rossini; Maria-Grazia Roncarolo; Claudio Bordignon; Chiara Bonini; Fabio Ciceri; Katharina Fleischhauer
Temporal, quantitative, and functional characteristics of single-KIR-positive alloreactive natural killer cell recovery account for impaired graft-versus-leukemia activity after haploidentical hematopoietic stem cell transplantation.
Blood 2008;112(8):3488-99.
2008: Alessandra Biffi; M Cesani; F Fumagalli; Ubaldo Del Carro; C Baldoli; S Canale; S Gerevini; Stefano Amadio; M Falautano; A Rovelli; G Comi; Maria-Grazia Roncarolo; Maria Sessa
Metachromatic leukodystrophy - mutation analysis provides further evidence of genotype-phenotype correlation.
Clinical genetics 2008;74(4):349-57.
2008: Ulrike Benninghoff; Federica Cattaneo; Alessandro Aiuti; Alberto Flores-D'Arcais; Carlo Gelmetti; Matteo Viscardi; Luciano Callegaro; Massimiliano Mirolo; alessandro ambrosi; Maria-Grazia Roncarolo; Rosa Bacchetta
Clinical improvement and normalized Th1 cytokine profile in early and long-term interferon-alpha treatment in a suspected case of hyper-IgE syndrome.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 2008;19(6):564-8.
2008: Paolo Monti; Miriam Scirpoli; Paola Maffi; Lorenzo Piemonti; Antonio Secchi; Ezio Bonifacio; Maria-Grazia Roncarolo; Manuela Battaglia
Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+CD25+FOXP3+ regulatory T-cells.
Diabetes 2008;57(9):2341-7.
2008: Ehud Hauben; Silvia Gregori; Elena Draghici; Barbara Migliavacca; Stefano Olivieri; Maximilian Woisetschläger; Maria-Grazia Roncarolo
Activation of the aryl hydrocarbon receptor promotes allograft-specific tolerance through direct and dendritic cell-mediated effects on regulatory T cells.
Blood 2008;112(4):1214-22.
2008: Sarah E Allan; Raewyn Broady; Silvia Gregori; Megan E Himmel; Natasha Locke; Maria-Grazia Roncarolo; Rosa Bacchetta; Megan K Levings
CD4+ T-regulatory cells: toward therapy for human diseases.
Immunological reviews 2008;223():391-421.
2008: Barbara Cassani; Massimiliano Mirolo; Federica Cattaneo; Ulrike Benninghoff; Michael Hershfield; Filippo Carlucci; Antonella Tabucchi; Claudio Bordignon; Maria-Grazia Roncarolo; Alessandro Aiuti
Altered intracellular and extracellular signaling leads to impaired T-cell functions in ADA-SCID patients.
Blood 2008;111(8):4209-19.
2008: Maria-Grazia Roncarolo; Silvia Gregori
Is FOXP3 a bona fide marker for human regulatory T cells?
European journal of immunology 2008;38(4):925-7.
2008: Laura Passerini; Sarah E Allan; Manuela Battaglia; Sara Di Nunzio; Alicia N Alstad; Megan K Levings; Maria-Grazia Roncarolo; Rosa Bacchetta
STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25- effector T cells.
International immunology 2008;20(3):421-31.
2008: Silvia Gregori; Manuela Battaglia; Maria-Grazia Roncarolo
Re-establishing immune tolerance in type 1 diabetes via regulatory T cells.
Novartis Foundation symposium 2008;292():174-83; discussion 183-6, 202-3.
2008: Sarah E Allan; Alicia N Alstad; Natacha Merindol; Natasha K Crellin; Mario Amendola; Rosa Bacchetta; Luigi Naldini; Maria-Grazia Roncarolo; Hugo Soudeyns; Megan K Levings
Generation of potent and stable human CD4+ T regulatory cells by activation-independent expression of FOXP3.
Molecular therapy : the journal of the American Society of Gene Therapy 2008;16(1):194-202.
2007: Ehud Hauben; Maria-Grazia Roncarolo; Elena Draghici; Uri Nevo
The role of tissue adaptation and graft size in immune tolerance.
Transplant immunology 2007;18(2):122-5.
2007: Andrea Annoni; Manuela Battaglia; Antonia Follenzi; Angelo Lombardo; Lucia Sergi Sergi; Luigi Naldini; Maria-Grazia Roncarolo
The immune response to lentiviral-delivered transgene is modulated in vivo by transgene-expressing antigen-presenting cells but not by CD4+CD25+ regulatory T cells.
Blood 2007;110(6):1788-96.
2007: Elisabetta Zino; Luca Vago; Simona Di Terlizzi; Benedetta Mazzi; Laura Zito; Elisabetta Sironi; silvano rossini; Chiara Bonini; Fabio Ciceri; Maria-Grazia Roncarolo; Claudio Bordignon; Katharina Fleischhauer
Frequency and targeted detection of HLA-DPB1 T cell epitope disparities relevant in unrelated hematopoietic stem cell transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2007;13(9):1031-40.
2007: Alessandro Aiuti; Barbara Cassani; Grazia Andolfi; Massimiliano Mirolo; Luca Biasco; Alessandra Recchia; Fabrizia Urbinati; Cristina Valacca; Samantha Scaramuzza; Memet Aker; Shimon Slavin; Matteo Cazzola; Daniela Sartori; alessandro ambrosi; Clelia Di Serio; Maria-Grazia Roncarolo; Fulvio Mavilio; Claudio Bordignon
Multilineage hematopoietic reconstitution without clonal selection in ADA-SCID patients treated with stem cell gene therapy.
The Journal of clinical investigation 2007;117(8):2233-40.
2007: Rosa Bacchetta; Eleonora Gambineri; Maria-Grazia Roncarolo
Role of regulatory T cells and FOXP3 in human diseases.
The Journal of allergy and clinical immunology 2007;120(2):227-35; quiz 236-7.
2007: Maria-Grazia Roncarolo; Manuela Battaglia
Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans.
Nature reviews. Immunology 2007;7(8):585-98.
2007: Sarah E Allan; Sarah Crome; Natasha K Crellin; Laura Passerini; Theodore S Steiner; Rosa Bacchetta; Maria-Grazia Roncarolo; Megan K Levings
Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production.
International immunology 2007;19(4):345-54.
2007: Brian D Brown; Giovanni Sitia; Andrea Annoni; Ehud Hauben; Lucia Sergi Sergi; Anna Zingale; Maria-Grazia Roncarolo; Luca G Guidotti; Luigi Naldini
In vivo administration of lentiviral vectors triggers a type I interferon response that restricts hepatocyte gene transfer and promotes vector clearance.
Blood 2007;109(7):2797-805.
2007: Sabine Charrier; Loic DUPRE; Samantha Scaramuzza; Laurence Jeanson-Leh; M P Blundell; Olivier Danos; Federica Cattaneo; Alessandro Aiuti; R Eckenberg; Adrian J Thrasher; Maria-Grazia Roncarolo; Anne Galy
Lentiviral vectors targeting WASp expression to hematopoietic cells, efficiently transduce and correct cells from WAS patients.
Gene therapy 2007;14(5):415-28.
2007: Francesco Marangoni; Sara Trifari; Samantha Scaramuzza; Cristina Panaroni; Silvana Martino; Luigi D Notarangelo; Zeina Baz; Ayse Metin; Federica Cattaneo; Anna Villa; Alessandro Aiuti; Manuela Battaglia; Maria-Grazia Roncarolo; Loic DUPRE
WASP regulates suppressor activity of human and murine CD4(+)CD25(+)FOXP3(+) natural regulatory T cells.
The Journal of experimental medicine 2007;204(2):369-80.
2007: Silvia Gregori; Rosa Bacchetta; Laura Passerini; Megan K Levings; Maria-Grazia Roncarolo
Isolation, expansion, and characterization of human natural and adaptive regulatory T cells.
Methods in molecular biology (Clifton, N.J.) 2007;380():83-105.
2007: Sara Deola; Samantha Scaramuzza; Roberto Sciarretta Birolo; Massimiliano Cergnul; Francesca Ficara; Jonathan Dando; Claudia Voena; Sergio Vai; Marta Monari; Enrico Pogliani; Gianmarco Corneo; Jacopo Peccatori; Silvia Selleri; Claudio Bordignon; Maria-Grazia Roncarolo; Alessandro Aiuti; Marco Bregni
Molecular purging of multiple myeloma cells by ex-vivo culture and retroviral transduction of mobilized-blood CD34+ cells.
Journal of translational medicine 2007;5():35.
2006: Manuela Battaglia; Angela Stabilini; Barbara Migliavacca; Jutta Horejs-Hoeck; Thomas Kaupper; Maria-Grazia Roncarolo
Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(12):8338-47.
2006: Sara Trifari; Giovanni Sitia; Alessandro Aiuti; Samantha Scaramuzza; Francesco Marangoni; Luca G Guidotti; Silvana Martino; Paola Saracco; Luigi D Notarangelo; Maria-Grazia Roncarolo; Loic DUPRE
Defective Th1 cytokine gene transcription in CD4+ and CD8+ T cells from Wiskott-Aldrich syndrome patients.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(10):7451-61.
2006: Alessandra Mortellaro; Raisa Jofra Hernandez; Matteo M Guerrini; Filippo Carlucci; Antonella Tabucchi; Maurilio Ponzoni; Francesca Sanvito; Claudio Doglioni; Clelia Di Serio; Luca Biasco; Antonia Follenzi; Luigi Naldini; Claudio Bordignon; Maria-Grazia Roncarolo; Alessandro Aiuti
Ex vivo gene therapy with lentiviral vectors rescues adenosine deaminase (ADA)-deficient mice and corrects their immune and metabolic defects.
Blood 2006;108(9):2979-88.
2006: Carmen Gianfrani; Megan K Levings; Claudia Sartirana; Giuseppe Mazzarella; Gianvincenzo Barba; Delia Zanzi; Alessandra Camarca; Gaetano Iaquinto; Nicola Giardullo; Salvatore Auricchio; Riccardo Troncone; Maria-Grazia Roncarolo
Gliadin-specific type 1 regulatory T cells from the intestinal mucosa of treated celiac patients inhibit pathogenic T cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(6):4178-86.
2006: Manuela Battaglia; Maria-Grazia Roncarolo
Induction of transplantation tolerance via regulatory T cells.
Inflammation & allergy drug targets 2006;5(3):157-65.
2006: Maria-Grazia Roncarolo; Silvia Gregori; Manuela Battaglia; Rosa Bacchetta; Katharina Fleischhauer; Megan K Levings
Interleukin-10-secreting type 1 regulatory T cells in rodents and humans.
Immunological reviews 2006;212():28-50.
2006: Diego Dolcetta; Laura Perani; Maria I Givogri; Francesca Galbiati; Stefano Amadio; Ubaldo Del Carro; G Finocchiaro; Alessandro Fanzani; Sergio Marchesini; Luigi Naldini; Maria-Grazia Roncarolo; Ernesto R Bongarzone
Design and optimization of lentiviral vectors for transfer of GALC expression in Twitcher brain.
The journal of gene medicine 2006;8(8):962-71.
2006: Rosa Bacchetta; Laura Passerini; Eleonora Gambineri; Minyue Dai; Sarah E Allan; Lucia Perroni; Franca Dagna Bricarelli; Claudia Sartirana; Susanne Matthes-Martin; Anita Lawitschka; Chiara Azzari; Steven F Ziegler; Megan K Levings; Maria-Grazia Roncarolo
Defective regulatory and effector T cell functions in patients with FOXP3 mutations.
The Journal of clinical investigation 2006;116(6):1713-22.
2006: Manuela Battaglia; Angela Stabilini; Elena Draghici; Barbara Migliavacca; Silvia Gregori; Ezio Bonifacio; Maria-Grazia Roncarolo
Induction of tolerance in type 1 diabetes via both CD4+CD25+ T regulatory cells and T regulatory type 1 cells.
Diabetes 2006;55(6):1571-80.
2006: Manuela Battaglia; Silvia Gregori; Rosa Bacchetta; Maria-Grazia Roncarolo
Tr1 cells: from discovery to their clinical application.
Seminars in immunology 2006;18(2):120-7.
2006: Loic DUPRE; Francesco Marangoni; Samantha Scaramuzza; Sara Trifari; Raisa Jofra Hernández; Alessandro Aiuti; Luigi Naldini; Maria-Grazia Roncarolo
Efficacy of gene therapy for Wiskott-Aldrich syndrome using a WAS promoter/cDNA-containing lentiviral vector and nonlethal irradiation.
Human gene therapy 2006;17(3):303-13.
2006: Manuela Battaglia; Angela Stabilini; Elena Draghici; Silvia Gregori; Cristina Mocchetti; Ezio Bonifacio; Maria-Grazia Roncarolo
Rapamycin and interleukin-10 treatment induces T regulatory type 1 cells that mediate antigen-specific transplantation tolerance.
Diabetes 2006;55(1):40-9.
2005: Silvia Gregori; Rosa Bacchetta; Ehud Hauben; Manuela Battaglia; Maria-Grazia Roncarolo
Regulatory T cells: prospective for clinical application in hematopoietic stem cell transplantation.
Current opinion in hematology 2005;12(6):451-6.
2005: Rosa Bacchetta; Silvia Gregori; Maria-Grazia Roncarolo
CD4+ regulatory T cells: mechanisms of induction and effector function.
Autoimmunity reviews 2005;4(8):491-6.
2005: Sarah E Allan; Laura Passerini; Rosa Bacchetta; Natasha K Crellin; Minyue Dai; Paul C Orban; Steven F Ziegler; Maria-Grazia Roncarolo; Megan K Levings
The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs.
The Journal of clinical investigation 2005;115(11):3276-84.
2005: Diego Dolcetta; Stefano Amadio; Uliano Guerrini; Maria I Givogri; Laura Perani; Francesca Galbiati; Luigi Sironi; Ubaldo Del Carro; Maria-Grazia Roncarolo; Ernesto R Bongarzone
Myelin deterioration in Twitcher mice: motor evoked potentials and magnetic resonance imaging as in vivo monitoring tools.
Journal of neuroscience research 2005;81(4):597-604.
2005: Manuela Battaglia; Angela Stabilini; Maria-Grazia Roncarolo
Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells.
Blood 2005;105(12):4743-8.
2005: Ehud Hauben; Maria-Grazia Roncarolo
Human CD4+ regulatory T cells and activation-induced tolerance.
Microbes and infection / Institut Pasteur 2005;7(7-8):1023-32.
2005: Rita Clementi; Franco Locatelli; Loic DUPRE; Alberto Garaventa; Lorenzo Emmi; Marco Bregni; Graziella Cefalo; Antonia Moretta; Cesare Danesino; Margherita Comis; Andrea Pession; Ugo Ramenghi; Rita Maccario; Maurizio Aricò; Maria-Grazia Roncarolo
A proportion of patients with lymphoma may harbor mutations of the perforin gene.
Blood 2005;105(11):4424-8.
2005: Loic DUPRE; Grazia Andolfi; Stuart G Tangye; Rita Clementi; Franco Locatelli; Maurizio Aricò; Alessandro Aiuti; Maria-Grazia Roncarolo
SAP controls the cytolytic activity of CD8+ T cells against EBV-infected cells.
Blood 2005;105(11):4383-9.
2005: Ehud Hauben; Maria-Grazia Roncarolo; Uri Nevo; Michal Schwartz
Beneficial autoimmunity in Type 1 diabetes mellitus.
Trends in immunology 2005;26(5):248-53.
2005: Silvia Gregori; Patrizia Mangia; Rosa Bacchetta; Eleonora Tresoldi; Frank Kolbinger; Catia Traversari; José M Carballido; Jan E de Vries; Ulf Korthäuer; Maria-Grazia Roncarolo
An anti-CD45RO/RB monoclonal antibody modulates T cell responses via induction of apoptosis and generation of regulatory T cells.
The Journal of experimental medicine 2005;201(8):1293-305.
2005: Cindy S Ma; Nathan J Hare; Kim E Nichols; Loic DUPRE; Grazia Andolfi; Maria-Grazia Roncarolo; Stephen Adelstein; Philip D Hodgkin; Stuart G Tangye
Impaired humoral immunity in X-linked lymphoproliferative disease is associated with defective IL-10 production by CD4+ T cells.
The Journal of clinical investigation 2005;115(4):1049-59.
2005: Megan K Levings; Silvia Gregori; Eleonora Tresoldi; Sabrina Cazzaniga; Chiara Bonini; Maria-Grazia Roncarolo
Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells.
Blood 2005;105(3):1162-9.
2005: Ehud Hauben; Rosa Bacchetta; Maria-Grazia Roncarolo
Utilizing regulatory T cells to control alloreactivity.
Cytotherapy 2005;7(2):158-65.
2005: Virginia M Salvati; Giuseppe Mazzarella; Carmen Gianfrani; Megan K Levings; Rosita Stefanile; Beatrice De Giulio; Gaetano Iaquinto; Nicola Giardullo; Salvatore Auricchio; Maria-Grazia Roncarolo; Riccardo Troncone
Recombinant human interleukin 10 suppresses gliadin dependent T cell activation in ex vivo cultured coeliac intestinal mucosa.
Gut 2005;54(1):46-53.
2004: Manuela Battaglia; Carmen Gianfrani; Silvia Gregori; Maria-Grazia Roncarolo
IL-10-producing T regulatory type 1 cells and oral tolerance.
Annals of the New York Academy of Sciences 2004;1029():142-53.
2004: Francesca Ficara; Daniela Superchi; Raisa Jofra Hernández; Cristina Mocchetti; Nicole Carballido-Perrig; Grazia Andolfi; Sara Deola; Augusto Colombo; Claudio Bordignon; José M Carballido; Maria-Grazia Roncarolo; Alessandro Aiuti
IL-3 or IL-7 increases ex vivo gene transfer efficiency in ADA-SCID BM CD34+ cells while maintaining in vivo lymphoid potential.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;10(6):1096-108.
2004: Loic DUPRE; Sara Trifari; Antonia Follenzi; Francesco Marangoni; Teresa Lain de Lera; Antonio Bernad; Silvana Martino; Shigeru Tsuchiya; Claudio Bordignon; Luigi Naldini; Alessandro Aiuti; Maria-Grazia Roncarolo
Lentiviral vector-mediated gene transfer in T cells from Wiskott-Aldrich syndrome patients leads to functional correction.
Molecular therapy : the journal of the American Society of Gene Therapy 2004;10(5):903-15.
2004: Diego Dolcetta; Laura Perani; Maria I Givogri; Francesca Galbiati; Antonio Orlacchio; Sabata Martino; Maria-Grazia Roncarolo; Ernesto R Bongarzone
Analysis of galactocerebrosidase activity in the mouse brain by a new histological staining method.
Journal of neuroscience research 2004;77(3):462-4.
2004: Antonia Follenzi; Manuela Battaglia; Angelo Lombardo; Andrea Annoni; Maria-Grazia Roncarolo; Luigi Naldini
Targeting lentiviral vector expression to hepatocytes limits transgene-specific immune response and establishes long-term expression of human antihemophilic factor IX in mice.
Blood 2004;103(10):3700-9.
2004: Jonathan Dando; Francesca Ficara; Sara Deola; Maria-Grazia Roncarolo; Claudio Bordignon; Alessandro Aiuti
Efficient gene transfer into primitive hematopoietic progenitors using a bone marrow microenvironment cell line engineered to produce retroviral vectors.
Haematologica 2004;89(4):462-70.
2004: Sara Deola; Samantha Scaramuzza; Roberto Sciarretta Birolo; Nicole Carballido-Perrig; Francesca Ficara; Cristina Mocchetti; Jonathan Dando; José M Carballido; Claudio Bordignon; Maria-Grazia Roncarolo; Marco Bregni; Alessandro Aiuti
Mobilized blood CD34+ cells transduced and selected with a clinically applicable protocol reconstitute lymphopoiesis in SCID-Hu mice.
Human gene therapy 2004;15(3):305-11.
2004: Manuela Battaglia; Maria-Grazia Roncarolo
The role of cytokines (and not only) in inducing and expanding T regulatory type 1 cells.
Transplantation 2004;77(1 Suppl):S16-8.
2003: Alessandro Aiuti; Francesca Ficara; Federica Cattaneo; Claudio Bordignon; Maria-Grazia Roncarolo
Gene therapy for adenosine deaminase deficiency.
Current opinion in allergy and clinical immunology 2003;3(6):461-6.
2003: Maria-Grazia Roncarolo; Manuela Battaglia; Silvia Gregori
The role of interleukin 10 in the control of autoimmunity.
Journal of autoimmunity 2003;20(4):269-72.
2003: Maria-Grazia Roncarolo; Silvia Gregori; Megan K Levings
Type 1 T regulatory cells and their relationship with CD4+CD25+ T regulatory cells.
Novartis Foundation symposium 2003;252():115-27; discussion 127-31, 203-10.
2002: Megan K Levings; Rosa Bacchetta; Ute Schulz; Maria-Grazia Roncarolo
The role of IL-10 and TGF-beta in the differentiation and effector function of T regulatory cells.
International archives of allergy and immunology 2002;129(4):263-76.
2002: Megan K Levings; Romina Sangregorio; Claudia Sartirana; Anna Lisa Moschin; Manuela Battaglia; Paul C Orban; Maria-Grazia Roncarolo
Human CD25+CD4+ T suppressor cell clones produce transforming growth factor beta, but not interleukin 10, and are distinct from type 1 T regulatory cells.
The Journal of experimental medicine 2002;196(10):1335-46.
2002: S Martinenghi; G Cusella De Angelis; S Biressi; Stefano Amadio; Francesco Bifari; Maria-Grazia Roncarolo; Claudio Bordignon; Luca Falqui
Human insulin production and amelioration of diabetes in mice by electrotransfer-enhanced plasmid DNA gene transfer to the skeletal muscle.
Gene therapy 2002;9(21):1429-37.
2002: Rosa Bacchetta; Claudia Sartirana; Megan K Levings; Claudio Bordignon; Satwant Narula; Maria-Grazia Roncarolo
Growth and expansion of human T regulatory type 1 cells are independent from TCR activation but require exogenous cytokines.
European journal of immunology 2002;32(8):2237-45.
2002: Loic DUPRE; Alessandro Aiuti; Sara Trifari; Silvana Martino; Paola Saracco; Claudio Bordignon; Maria-Grazia Roncarolo
Wiskott-Aldrich syndrome protein regulates lipid raft dynamics during immunological synapse formation.
Immunity 2002;17(2):157-66.
2002: Alessandro Aiuti; Shimon Slavin; Memet Aker; Francesca Ficara; Sara Deola; Alessandra Mortellaro; Shoshana Morecki; Grazia Andolfi; Antonella Tabucchi; Filippo Carlucci; Enrico Marinello; Federica Cattaneo; Sergio Vai; Paolo Servida; Roberto Miniero; Maria-Grazia Roncarolo; Claudio Bordignon
Correction of ADA-SCID by stem cell gene therapy combined with nonmyeloablative conditioning.
Science (New York, N.Y.) 2002;296(5577):2410-3.
2002: Alessandro Aiuti; Sergio Vai; Alessandra Mortellaro; Giulia Casorati; Francesca Ficara; Grazia Andolfi; Giuliana Ferrari; Antonella Tabucchi; Filippo Carlucci; Hans D Ochs; Luigi D Notarangelo; Maria-Grazia Roncarolo; Claudio Bordignon
Immune reconstitution in ADA-SCID after PBL gene therapy and discontinuation of enzyme replacement.
Nature medicine 2002;8(5):423-5.
2002: Manuela Battaglia; Bruce R Blazar; Maria-Grazia Roncarolo
The puzzling world of murine T regulatory cells.
Microbes and infection / Institut Pasteur 2002;4(5):559-66.
2001: Jonathan Dando; Maria-Grazia Roncarolo; Claudio Bordignon; Alessandro Aiuti
A novel human packaging cell line with hematopoietic supportive capacity increases gene transfer into early hematopoietic progenitors.
Human gene therapy 2001;12(16):1979-88.
2001: Maria-Grazia Roncarolo; Rosa Bacchetta; Claudio Bordignon; S Narula; Megan K Levings
Type 1 T regulatory cells.
Immunological reviews 2001;182():68-79.
2001: Megan K Levings; Romina Sangregorio; Maria-Grazia Roncarolo
Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function.
The Journal of experimental medicine 2001;193(11):1295-302.
2001: Maria-Grazia Roncarolo; J M Carballido
Construction of human-SCID chimeric mice.
Current protocols in immunology / edited by John E. Coligan ... [et al.] 2001;Chapter 4():Unit 4.8.
2001: Megan K Levings; Romina Sangregorio; F Galbiati; S Squadrone; Rene de Waal Malefyt; Maria-Grazia Roncarolo
IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(9):5530-9.
2001: Maria-Grazia Roncarolo; Megan K Levings; Catia Traversari
Differentiation of T regulatory cells by immature dendritic cells.
The Journal of experimental medicine 2001;193(2):F5-9.
2000: Maria-Grazia Roncarolo; Megan K Levings
The role of different subsets of T regulatory cells in controlling autoimmunity.
Current opinion in immunology 2000;12(6):676-83.
2000: M K Levings; Maria-Grazia Roncarolo
T-regulatory 1 cells: a novel subset of CD4 T cells with immunoregulatory properties.
The Journal of allergy and clinical immunology 2000;106(1 Pt 2):S109-12.
2000: José M Carballido; R Namikawa; Nicole Carballido-Perrig; Svetlana Antonenko; Maria-Grazia Roncarolo; Jan E de Vries
Generation of primary antigen-specific human T- and B-cell responses in immunocompetent SCID-hu mice.
Nature medicine 2000;6(1):103-6.
1999: M Rouleau; Françoise Cottrez; Mike E Bigler; Svetlana Antonenko; José M Carballido; Albert Zlotnik; Maria-Grazia Roncarolo; Hervé Groux
IL-10 transgenic mice present a defect in T cell development reminiscent of SCID patients.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(3):1420-7.
1999: R Namikawa; Marcus O Muench; M T Firpo; L Humeau; Y Xu; Satish Menon; Maria-Grazia Roncarolo
Administration of Flk2/Flt3 ligand induces expansion of human high-proliferative potential colony-forming cells in the SCID-hu mouse.
Experimental hematology 1999;27(6):1029-37.
1999: L Humeau; R Namikawa; Florence Bardin; Patrice Mannoni; Maria-Grazia Roncarolo; Christian Chabannon
Ex vivo manipulations alter the reconstitution potential of mobilized human CD34+ peripheral blood progenitors.
Leukemia 1999;13(3):438-52.
1999: Hervé Groux; Françoise Cottrez; M Rouleau; Smita Mauze; Svetlana Antonenko; Stephen D Hurst; T McNeil; Mike E Bigler; Maria-Grazia Roncarolo; Robert L Coffman
A transgenic model to analyze the immunoregulatory role of IL-10 secreted by antigen-presenting cells.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(3):1723-9.
1998: Maria-Grazia Roncarolo
Immuno responses of cord blood cells.
Bone marrow transplantation 1998;22 Suppl 1():S55.
1998: Hervé Groux; Mike E Bigler; Jan E de Vries; Maria-Grazia Roncarolo
Inhibitory and stimulatory effects of IL-10 on human CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(7):3188-93.
1997: L Humeau; Christian Chabannon; M T Firpo; Patrice Mannoni; Claude BAGNIS; Maria-Grazia Roncarolo; R Namikawa
Successful reconstitution of human hematopoiesis in the SCID-hu mouse by genetically modified, highly enriched progenitors isolated from fetal liver.
Blood 1997;90(9):3496-506.
1997: Hervé Groux; Anne O'Garra; Mike E Bigler; M Rouleau; Svetlana Antonenko; Jan E de Vries; Maria-Grazia Roncarolo
A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis.
Nature 1997;389(6652):737-42.
1997: Hervé Groux; Sornasse Thierry; Françoise Cottrez; Jan E de Vries; Robert L Coffman; Maria-Grazia Roncarolo; Hans Yssel
Induction of human T helper cell type 1 differentiation results in loss of IFN-gamma receptor beta-chain expression.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(12):5627-31.
1997: Marcus O Muench; Maria-Grazia Roncarolo; O Rosnet; D Birnbaum; R Namikawa
Colony-forming cells expressing high levels of CD34 are the main targets for granulocyte colony-stimulating factor and macrophage colony-stimulating factor in the human fetal liver.
Experimental hematology 1997;25(4):277-87.
1997: Marcus O Muench; Maria-Grazia Roncarolo; R Namikawa
Phenotypic and functional evidence for the expression of CD4 by hematopoietic stem cells isolated from human fetal liver.
Blood 1997;89(4):1364-75.
1996: M Rouleau; R Namikawa; Svetlana Antonenko; N Carballido-Perrig; Maria-Grazia Roncarolo
Antigen-specific cytotoxic T cells mediate human fetal pancreas allograft rejection in SCID-hu mice.
Journal of immunology (Baltimore, Md. : 1950) 1996;157(12):5710-20.
1996: Maria-Grazia Roncarolo; J M Carballido; M Rouleau; R Namikawa; Jan E de Vries
Human T-and B-cell functions in SCID-hu mice.
Seminars in immunology 1996;8(4):207-13.
1996: R Namikawa; Marcus O Muench; Maria-Grazia Roncarolo
Regulatory roles of the ligand for Flk2/Flt3 tyrosine kinase receptor on human hematopoiesis.
Stem cells (Dayton, Ohio) 1996;14(4):388-95.
1996: Hervé Groux; Mike E Bigler; Jan E de Vries; Maria-Grazia Roncarolo
Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells.
The Journal of experimental medicine 1996;184(1):19-29.
1996: Maria-Grazia Roncarolo; Mike E Bigler; S Martino; E Ciuti; P A Tovo; J Wagner
Immune functions of cord blood cells before and after transplantation.
Journal of hematotherapy 1996;5(2):157-60.
1996: R Namikawa; Marcus O Muench; Jan E de Vries; Maria-Grazia Roncarolo
The FLK2/FLT3 ligand synergizes with interleukin-7 in promoting stromal-cell-independent expansion and differentiation of human fetal pro-B cells in vitro.
Blood 1996;87(5):1881-90.
1995: Hervé Groux; M Rouleau; R Bacchetta; Maria-Grazia Roncarolo
T-cell subsets and their cytokine profiles in transplantation and tolerance.
Annals of the New York Academy of Sciences 1995;770():141-8.
1995: José M Carballido; D Schols; R Namikawa; Sandra Zurawski; Gerard Zurawski; Maria-Grazia Roncarolo; Jan E de Vries
IL-4 induces human B cell maturation and IgE synthesis in SCID-hu mice. Inhibition of ongoing IgE production by in vivo treatment with an IL-4/IL-13 receptor antagonist.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(9):4162-70.
1995: Roberto Miniero; Alessandro Busca; Maria-Grazia Roncarolo; M Saitta; A Iavarone; Fabio Timeus; A Biondi; Antonio Amoroso; L Perugini; E Ciuti
HLA-haploidentical umbilical cord blood stem cell transplantation in a child with advanced leukemia: clinical outcome and analysis of hematopoietic recovery.
Bone marrow transplantation 1995;16(2):229-40.
1995: R Bacchetta; R Parkman; M McMahon; K Weinberg; Mike E Bigler; Jan E de Vries; Maria-Grazia Roncarolo
Dysfunctional cytokine production by host-reactive T-cell clones isolated from a chimeric severe combined immunodeficiency patient transplanted with haploidentical bone marrow.
Blood 1995;85(7):1944-53.
1995: D Schols; D Jones; Maria-Grazia Roncarolo
Unique cytokine production profile of anergic human T cells in SCID-hu mice after staphylococcal enterotoxin B administration.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(7):3204-12.
1995: Alicia Bárcena; Marcus O Muench; Maria-Grazia Roncarolo; H Spits
Tracing the expression of CD7 and other antigens during T- and myeloid-cell differentiation in the human fetal liver and thymus.
Leukemia & lymphoma 1995;17(1-2):1-11.
1995: Marcus O Muench; Maria-Grazia Roncarolo; Satish Menon; Y Xu; Robert A Kastelein; Sandra Zurawski; C H Hannum; J Culpepper; F Lee; R Namikawa
FLK-2/FLT-3 ligand regulates the growth of early myeloid progenitors isolated from human fetal liver.
Blood 1995;85(4):963-72.
1995: Jean-Louis Touraine; R Bacchetta; H Yssel; J de Vries; Maria-Grazia Roncarolo
Transplantation of mismatched human fetal liver cells: tolerance induction via clonal deletion and clonal anergy.
Transplantation proceedings 1995;27(1):622-4.
1994: Marcus O Muench; Maria-Grazia Roncarolo; R Namikawa; Alicia Bárcena; Malcolm A S Moore
Progress in the ex vivo expansion of hematopoietic progenitors.
Leukemia & lymphoma 1994;16(1-2):1-11.
1994: M J Sánchez; Marcus O Muench; Maria-Grazia Roncarolo; Lewis L Lanier; Joseph H Phillips
Identification of a common T/natural killer cell progenitor in human fetal thymus.
The Journal of experimental medicine 1994;180(2):569-76.
1994: Alicia Bárcena; A H Galy; J Punnonen; Marcus O Muench; D Schols; Maria-Grazia Roncarolo; Jan E de Vries; H Spits
Lymphoid and myeloid differentiation of fetal liver CD34+lineage- cells in human thymic organ culture.
The Journal of experimental medicine 1994;180(1):123-32.
1994: Marcus O Muench; J Cupp; J Polakoff; Maria-Grazia Roncarolo
Expression of CD33, CD38, and HLA-DR on CD34+ human fetal liver progenitors with a high proliferative potential.
Blood 1994;83(11):3170-81.
1994: D Schols; B Vandekerckhove; D Jones; Maria-Grazia Roncarolo
IL-2 reverses human T cell unresponsiveness induced by thymic epithelium in SCID-hu mice.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(5):2198-206.
1994: B A Vandekerckhove; Alicia Bárcena; D Schols; S Mohan-Peterson; H Spits; Maria-Grazia Roncarolo
In vivo cytokine expression in the thymus. CD3high human thymocytes are activated and already functionally differentiated in helper and cytotoxic cells.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(4):1738-43.
1994: R Bacchetta; Mike E Bigler; Jean-Louis Touraine; R Parkman; P A Tovo; J Abrams; Rene de Waal Malefyt; Jan E de Vries; Maria-Grazia Roncarolo
High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells.
The Journal of experimental medicine 1994;179(2):493-502.
1994: Alicia Bárcena; Marcus O Muench; Maria-Grazia Roncarolo; H Spits
In search of T-cell progenitors in the human foetal liver.
Research in immunology 1994;145(2):120-3; discussion 155-8.
1994: Maria-Grazia Roncarolo; Mike E Bigler; E Ciuti; S Martino; P A Tovo
Immune responses by cord blood cells.
Blood cells 1994;20(2-3):573-85; discussion 585-6.
1993: Alicia Bárcena; Marcus O Muench; A H Galy; J Cupp; Maria-Grazia Roncarolo; J H Phillips; H Spits
Phenotypic and functional analysis of T-cell precursors in the human fetal liver and thymus: CD7 expression in the early stages of T- and myeloid-cell development.
Blood 1993;82(11):3401-14.
1993: Jean-Louis Touraine; Maria-Grazia Roncarolo; H Plotnicky; R Bachetta; H Spits
T lymphocytes from human chimeras do recognize antigen in the context of allogeneic determinants of the major histocompatibility complex.
Immunology letters 1993;39(1):9-12.
1993: B A Vandekerckhove; D Jones; J Punnonen; D Schols; H C Lin; B Duncan; R Bacchetta; Jan E de Vries; Maria-Grazia Roncarolo
Human Ig production and isotype switching in severe combined immunodeficient-human mice.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(1):128-37.
1993: R Baccala; B A Vandekerckhove; D Jones; Dwight H Kono; Maria-Grazia Roncarolo; Argyrios N Theofilopoulos
Bacterial superantigens mediate T cell deletions in the mouse severe combined immunodeficiency-human liver/thymus model.
The Journal of experimental medicine 1993;177(5):1481-5.
1993: R Bacchetta; B A Vandekerckhove; Jean-Louis Touraine; Mike E Bigler; S Martino; Lucette Gebuhrer; Jan E de Vries; H Spits; Maria-Grazia Roncarolo
Chimerism and tolerance to host and donor in severe combined immunodeficiencies transplanted with fetal liver stem cells.
The Journal of clinical investigation 1993;91(3):1067-78.
1993: Jean-Louis Touraine; Maria-Grazia Roncarolo; R Bacchetta; Daniel Raudrant; A Rebaud; S Laplace; P Cesbron; Lucette Gebuhrer; M T Zabot; F Touraine
Fetal liver transplantation: biology and clinical results.
Bone marrow transplantation 1993;11 Suppl 1():119-22.
1992: B A Vandekerckhove; R Baccala; D Jones; Dwight H Kono; Argyrios N Theofilopoulos; Maria-Grazia Roncarolo
Thymic selection of the human T cell receptor V beta repertoire in SCID-hu mice.
The Journal of experimental medicine 1992;176(6):1619-24.
1992: M T Bejarano; Rene de Waal Malefyt; J S Abrams; Mike E Bigler; R Bacchetta; Jan E de Vries; Maria-Grazia Roncarolo
Interleukin 10 inhibits allogeneic proliferative and cytotoxic T cell responses generated in primary mixed lymphocyte cultures.
International immunology 1992;4(12):1389-97.
1992: Hans Yssel; Rene de Waal Malefyt; Maria-Grazia Roncarolo; J S Abrams; R Lahesmaa; H Spits; Jan E de Vries
IL-10 is produced by subsets of human CD4+ T cell clones and peripheral blood T cells.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(7):2378-84.
1992: J Punnonen; Gregorio Aversa; B Vandekerckhove; Maria-Grazia Roncarolo; Jan E de Vries
Induction of isotype switching and Ig production by CD5+ and CD10+ human fetal B cells.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(11):3398-404.
1992: H Gascan; Gregorio Aversa; J F Gauchat; P Van Vlasselaer; Maria-Grazia Roncarolo; Hans Yssel; M Kehry; H Spits; Jan E de Vries
Membranes of activated CD4+ T cells expressing T cell receptor (TcR) alpha beta or TcR gamma delta induce IgE synthesis by human B cells in the presence of interleukin-4.
European journal of immunology 1992;22(5):1133-41.
1992: B A Vandekerckhove; R Namikawa; R Bacchetta; Maria-Grazia Roncarolo
Human hematopoietic cells and thymic epithelial cells induce tolerance via different mechanisms in the SCID-hu mouse thymus.
The Journal of experimental medicine 1992;175(4):1033-43.
1992: Maria-Grazia Roncarolo; B Vandekerckhove
SCID-hu mice as a model to study tolerance after fetal stem cell transplantation.
Bone marrow transplantation 1992;9 Suppl 1():83-4.
1992: Maria-Grazia Roncarolo; R Bacchetta
T cell repertoire and tolerance after fetal stem cell transplantation.
Bone marrow transplantation 1992;9 Suppl 1():127-8.
1992: Jean-Louis Touraine; Daniel Raudrant; A Rebaud; Maria-Grazia Roncarolo; S Laplace; Lucette Gebuhrer; H Betuel; D Frappaz; F Freycon; M T Zabot
In utero transplantation of stem cells in humans: immunological aspects and clinical follow-up of patients.
Bone marrow transplantation 1992;9 Suppl 1():121-6.
1991: Maria-Grazia Roncarolo; Mike E Bigler; J B Haanen; Hans Yssel; R Bacchetta; Jan E de Vries; H Spits
Natural killer cell clones can efficiently process and present protein antigens.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(3):781-7.
1991: B A Vandekerckhove; J F Krowka; Joseph M McCune; J E de Vries; H Spits; Maria-Grazia Roncarolo
Clonal analysis of the peripheral T cell compartment of the SCID-hu mouse.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(12):4173-9.
1991: T Hori; Rene de Waal Malefyt; B W Duncan; M R Harrison; Maria-Grazia Roncarolo; H Spits
Cloning of a novel cell type from human fetal liver expressing cytoplasmic CD3 delta and epsilon but not membrane CD3.
International immunology 1991;3(4):353-7.
1991: J F Gauchat; H Gascan; Maria-Grazia Roncarolo; F Rousset; J Pène; Jan E de Vries
Regulation of human IgE synthesis: the role of CD4+ and CD8+ T-cells and the inhibitory effects of interferon-alpha.
The European respiratory journal. Supplement 1991;13():31s-38s.
1991: H Gascan; J F Gauchat; Maria-Grazia Roncarolo; Hans Yssel; H Spits; Jan E de Vries
Human B cell clones can be induced to proliferate and to switch to IgE and IgG4 synthesis by interleukin 4 and a signal provided by activated CD4+ T cell clones.
The Journal of experimental medicine 1991;173(3):747-50.
1991: Jean-Louis Touraine; Daniel Raudrant; C Royo; A Rebaud; F Barbier; Maria-Grazia Roncarolo; F Touraine; S Laplace; Lucette Gebuhrer; H Bétuel
In utero transplantation of hemopoietic stem cells in humans.
Transplantation proceedings 1991;23(1 Pt 2):1706-8.
1991: Jean-Louis Touraine; Daniel Raudrant; C Vullo; D Frappaz; F Freycon; A Rebaud; F Barbier; Maria-Grazia Roncarolo; Lucette Gebuhrer; H Bétuel
New developments in stem cell transplantation with special reference to the first in utero transplants in humans.
Bone marrow transplantation 1991;7 Suppl 3():92-7.
1991: Jan E de Vries; Rene de Waal Malefyt; Hans Yssel; Maria-Grazia Roncarolo; H Spits
Do human TH1 and TH2 CD4+ clones exist?
Research in immunology 1991;142(1):59-63.
1991: Maria-Grazia Roncarolo; R Bacchetta; Mike E Bigler; Jean-Louis Touraine; Jan E de Vries; H Spits
A SCID patient reconstituted with HLA-incompatible fetal stem cells as a model for studying transplantation tolerance.
Blood cells 1991;17(2):391-402.
1990: G Pastorelli; Maria-Grazia Roncarolo; C Peronne; Pier-Angelo Tovo; Jan E de Vries
The capacity of interleukin-4 to induce in vitro IgE synthesis by B cells of patients with common variable immunodeficiency.
Clinical and experimental immunology 1990;82(1):120-7.
1990: G Pastorelli; F Rousset; J Pène; C Peronne; Maria-Grazia Roncarolo; Pier-Angelo Tovo; Jan E de Vries
Cord blood B cells are mature in their capacity to switch to IgE-producing cells in response to interleukin-4 in vitro.
Clinical and experimental immunology 1990;82(1):114-9.
1990: H Spits; Jean-Louis Touraine; Hans Yssel; Jan E de Vries; Maria-Grazia Roncarolo
Presence of host-reactive and MHC-restricted T cells in a transplanted severe combined immunodeficient (SCID) patient suggest positive selection and absence of clonal deletion.
Immunological reviews 1990;116():101-16.
1990: R Bacchetta; R de Waal Malefijt; Hans Yssel; J Abrams; Jan E de Vries; H Spits; Maria-Grazia Roncarolo
Host-reactive CD4+ and CD8+ T cell clones isolated from a human chimera produce IL-5, IL-2, IFN-gamma and granulocyte/macrophage-colony-stimulating factor but not IL-4.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(3):902-8.
1989: G Pastorelli; Maria-Grazia Roncarolo; J L Touraine; F Rousset; J Pene; Jan E de Vries
Interleukin-4 suppresses immunoglobulin production by peripheral blood lymphocytes of patients with common variable immunodeficiency (CVI) induced by supernatants of T cell clones.
Clinical and experimental immunology 1989;78(3):341-7.
1989: G Pastorelli; Maria-Grazia Roncarolo; J L Touraine; G Peronne; Pier-Angelo Tovo; Jan E de Vries
Peripheral blood lymphocytes of patients with common variable immunodeficiency (CVI) produce reduced levels of interleukin-4, interleukin-2 and interferon-gamma, but proliferate normally upon activation by mitogens.
Clinical and experimental immunology 1989;78(3):334-40.
1989: Jean-Louis Touraine; Daniel Raudrant; C Royo; A Rebaud; Maria-Grazia Roncarolo; G Souillet; N Philippe; F Touraine; H Bétuel
In-utero transplantation of stem cells in bare lymphocyte syndrome.
Lancet 1989;1(8651):1382.
1989: Jean-Louis Touraine; C Royo; Maria-Grazia Roncarolo; K Murray; O de Bouteiller
Unmatched stem cell transplantation as a possible alternative to bone marrow transplantation.
Transplantation proceedings 1989;21(1 Pt 3):3112-3.
1988: Maria-Grazia Roncarolo; Hans Yssel; Jean-Louis Touraine; R Bacchetta; Lucette Gebuhrer; Jan E de Vries; H Spits
Antigen recognition by MHC-incompatible cells of a human mismatched chimera.
The Journal of experimental medicine 1988;168(6):2139-52.
1988: Maria-Grazia Roncarolo; M Zoppo; R Bacchetta; Clara Gabiano; C Sacchetti; Franco Cerutti; Pier-Angelo Tovo
Interleukin-2 production and interleukin-2 receptor expression in children with newly diagnosed diabetes.
Clinical immunology and immunopathology 1988;49(1):53-62.
1987: Jean-Louis Touraine; Maria-Grazia Roncarolo; C Royo; F Touraine
Fetal tissue transplantation, bone marrow transplantation and prospective gene therapy in severe immunodeficiencies and enzyme deficiencies.
Thymus 1987;10(1-2):75-87.
1985: Jean-Louis Touraine; Maria-Grazia Roncarolo; G L Marseglia; G Souillet; B Bétend; H Bétuel; F Touraine; C Royo; N Philippe; R François
Fetal liver transplantation in immunodeficiencies and inborn errors of metabolism.
Progress in clinical and biological research 1985;193():299-313.
1985: Pier-Angelo Tovo; Clara Gabiano; Maria-Grazia Roncarolo; A M Delpiano; M Saitta; M C Giubellino; R Foa
Relevance of anti-T monoclonal antibodies in the study of children with primary immunodeficiencies.
Bollettino dell'Istituto sieroterapico milanese 1985;64(2):135-41.