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Darell Bigner

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Vidyalakshmi Chandramohan; Mika Kato Kaneko; Yukinari Kato; Stephen T Keir; Chien-Tsun Kuan; Ira H Pastan; Scott E Szafranski; Xuhui Bao; Darell D Bigner
Recombinant anti-podoplanin (NZ-1) immunotoxin for the treatment of malignant brain tumors.
Ethan Poteet; Myoung-Gwi Ryou; James W Simpkins; Lin Tang; Yi Wen; Ali Winters; Hai Yan; Darell D Bigner; Gourav Roy Choudhury; Anuja Ghorpade; Stephen T Keir; Wenjun Li; Ran Liu; Fang Yuan; Shao-Hua Yang
Reversing the warburg effect as a treatment for glioblastoma.
Genglin Jin; Giselle Y Lopez; Roger E McLendon; B Ahmed Rasheed; Zachary J Reitman; Ivan Spasojevic; Darell D Bigner; Christopher G Duncan; David M Gooden; Yiping He; Rui Yang; Hai Yan
Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas.

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All Publications

2013: Vidyalakshmi Chandramohan; Mika Kato Kaneko; Yukinari Kato; Stephen T Keir; Chien-Tsun Kuan; Ira H Pastan; Scott E Szafranski; Xuhui Bao; Darell D Bigner
Recombinant anti-podoplanin (NZ-1) immunotoxin for the treatment of malignant brain tumors.
International journal of cancer. Journal international du cancer 2013;132(10):2339-48.
2013: Ethan Poteet; Myoung-Gwi Ryou; James W Simpkins; Lin Tang; Yi Wen; Ali Winters; Hai Yan; Darell D Bigner; Gourav Roy Choudhury; Anuja Ghorpade; Stephen T Keir; Wenjun Li; Ran Liu; Fang Yuan; Shao-Hua Yang
Reversing the warburg effect as a treatment for glioblastoma.
The Journal of biological chemistry 2013;288(13):9153-64.
2013: Genglin Jin; Giselle Y Lopez; Roger E McLendon; B Ahmed Rasheed; Zachary J Reitman; Ivan Spasojevic; Darell D Bigner; Christopher G Duncan; David M Gooden; Yiping He; Rui Yang; Hai Yan
Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas.
Cancer research 2013;73(2):496-501.
2013: Bryan D Choi; Patrick C Gedeon; Chien-Tsun Kuan; Duane A Mitchell; Ira Pastan; Gary E Archer; Darell D Bigner; Mingqing Cai; Luis Sanchez-Perez; John H Sampson
Systemic administration of a bispecific antibody targeting EGFRvIII successfully treats intracerebral glioma.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(1):270-5.
2013: Luis A Sanchez-Perez; Robert J Schmittling; David Snyder; Gary E Archer; Darell D Bigner; Bryan D Choi; Xiuyu Cui; Catherine Flores; James E Herndon; Laura A Johnson; Duane A Mitchell; John H Sampson
Myeloablative temozolomide enhances CD8⁺ T-cell responses to vaccine and is required for efficacy against brain tumors in mice.
PloS one 2013;8(3):e59082.
2013: Stephen T Keir; David A Reardon; Darell D Bigner; Henry S Friedman; Lloyd A Gray
Mibefradil, a novel therapy for glioblastoma multiforme: cell cycle synchronization and interlaced therapy in a murine model.
Journal of neuro-oncology 2013;111(2):97-102.
2012: Huilin Shao; Ralph Weissleder; Leonora Balaj; Darell D Bigner; Xandra O Breakefield; Bob S Carter; Alain Charest; Jaehoon Chung; Fred H Hochberg; Hakho Lee
Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy.
Nature medicine 2012;18(12):1835-40.
2012: Christopher G Duncan; Genglin Jin; Priya Kapoor-Vazirani; Doris R Powell; Carlo Rago; Paula M Vertino; Benjamin G Barwick; Darell D Bigner; Jen-Tsan Chi; Hai Yan
A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation.
Genome research 2012;22(12):2339-55.
2012: Ankit I Mehta; Ira Pastan; Raghu Raghavan; Divya Ajay; Darell D Bigner; Martin Brady; Bryan D Choi; Allan H Friedman; John H Sampson
Convection enhanced delivery of macromolecules for brain tumors.
Current drug discovery technologies 2012;9(4):305-10.
2012: Steven N Gurley; Stephen T Keir; Stanley D Kosanke; Ammaar H Abidi; Patrick Allison; Darell D Bigner; Christopher D Duntsch; Andrea J Elberger; Peihong Guan; Jon H Robertson; Bob Moore
Mechanism of anti-glioma activity and in vivo efficacy of the cannabinoid ligand KM-233.
Journal of neuro-oncology 2012;110(2):163-77.
2012: Changcun Guo; Darell D Bigner; Chun-Chi Chang; Lee H Chen; Jen-Tsan Chi; Young-Wook Cho; Kai Ge; Gerald A Grant; Dawn N Kernagis; Roger E McLendon; Nickolas Papadopoulos; Xiaoxia Qin; Matthew Wortham; Hai Yan; Yiping He
Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathways.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(43):17603-8.
2012: David A Reardon; Jeremy Rich; John H Sampson; Sith Sathornsumetee; A L Sumrall; S Turner; Darell D Bigner; S T Boulton; A Coan; Annick Desjardins; Allan H Friedman; Henry S Friedman; James E Herndon; E S Lipp; E Lou; K B Peters; James J Vredenburgh
Bevacizumab continuation beyond initial bevacizumab progression among recurrent glioblastoma patients.
British journal of cancer 2012;107(9):1481-7.
2012: Genglin Jin; Giselle Y Lopez; Christopher J Pirozzi; Ivan Spasojevic; Darell D Bigner; Lee H Chen; Christopher G Duncan; Jie Feng; Yiping He; Hai Yan
Mutant IDH1 is required for IDH1 mutated tumor cell growth.
Oncotarget 2012;3(8):774-82.
2012: Yuchen Jiao; Patrick J Killela; Kenneth W Kinzler; Eric Lipp; Giselle Lopez; Roger McLendon; Alan K Meeker; Sueli M Oba-Shinjo; Nickolas Papadopoulos; Christopher Pirozzi; Ahmed B Rasheed; Zachary J Reitman; Gregory J Riggins; Fausto J Rodriguez; Sergio Rosemberg; Bert Vogelstein; Nishant Agrawal; Chetan Bettegowda; Darell D Bigner; Peter C Burger; Roeland F de Wilde; Luis Alberto Diaz; Allan H Friedman; Henry Friedman; Yiping He; Christopher M Heaphy; Matthias Holdhoff; Suely Kazue Nagahashi Marie; Hai Yan
Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas.
Oncotarget 2012;3(7):709-22.
2012: Matthew Wortham; Darell D Bigner; Yiping He; Genglin Jin; Julia Lailai Sun; Hai Yan
Aberrant Otx2 expression enhances migration and induces ectopic proliferation of hindbrain neuronal progenitor cells.
PloS one 2012;7(4):e36211.
2012: Vidyalakshmi Chandramohan; Ira Pastan; John H Sampson; Darell D Bigner
Toxin-based targeted therapy for malignant brain tumors.
Clinical & developmental immunology 2012;2012():480429.
2012: John H Sampson; Robert J Schmittling; James J Vredenburgh; Smita K Nair; Elizabeth A Reap; David A Reardon; Gary E Archer; Darell D Bigner; April Coan; Kendra L Congdon; Annick Desjardins; Allan H Friedman; Henry S Friedman; James E Herndon; Roger E McLendon; Duane A Mitchell
A pilot study of IL-2Rα blockade during lymphopenia depletes regulatory T-cells and correlates with enhanced immunity in patients with glioblastoma.
PloS one 2012;7(2):e31046.
2011: Duane A Mitchell; David A Reardon; Luis Sanchez-Perez; Robert J Schmittling; David J Snyder; James J Vredenburgh; Gary E Archer; Darell D Bigner; Kendra L Congdon; Xiuyu Cui; Annick Desjardins; Allan H Friedman; Henry S Friedman; James E Herndon; Roger E McLendon; John H Sampson
Monoclonal antibody blockade of IL-2 receptor α during lymphopenia selectively depletes regulatory T cells in mice and humans.
Blood 2011;118(11):3003-12.
2011: John H Sampson; Terence Z Wong; Michael R Zalutsky; Daniel P Barboriak; Martin Brady; Allan H Friedman; Denise Lally-Goss; Ankit I Mehta; Neil Petry; Raghu Raghavan; David A Reardon; Darell D Bigner
Colocalization of gadolinium-diethylene triamine pentaacetic acid with high-molecular-weight molecules after intracerebral convection-enhanced delivery in humans.
Neurosurgery 2011;69(3):668-76.
2011: Christopher M Heaphy; Sachidanand Hebbar; Ralph Hruban; Yuchen Jiao; Kenneth W Kinzler; Alison P Klein; Anirban Maitra; Suely Kazue Nagahashi Marie; Roger McLendon; Sueli M Oba-Shinjo; G Johan A Offerhaus; Nickolas Papadopoulos; B Ahmed Rasheed; Gregory J Riggins; Fausto J Rodriguez; Chanjuan Shi; Bert Vogelstein; Hai Yan; Chetan Bettegowda; Darell D Bigner; Roeland F de Wilde; Charles G Eberhart; BARISH EDIL; Yiping He; Alan K Meeker
Altered telomeres in tumors with ATRX and DAXX mutations.
Science (New York, N.Y.) 2011;333(6041):425.
2011: Bryan D Choi; Mingqing Cai; Darell D Bigner; Ankit I Mehta; Chien-Tsun Kuan; John H Sampson
Bispecific antibodies engage T cells for antitumor immunotherapy.
Expert opinion on biological therapy 2011;11(7):843-53.
2011: Chien-Tsun Kuan; Kenji Wakiya; Stephen T Keir; Jianjun Li; James E Herndon; Ira Pastan; Darell D Bigner
Affinity-matured anti-glycoprotein NMB recombinant immunotoxins targeting malignant gliomas and melanomas.
International journal of cancer. Journal international du cancer 2011;129(1):111-21.
2011: James J Vredenburgh; Leighann Bailey; Darell D Bigner; Annick Desjardins; Allan H Friedman; James E Herndon; John P Kirkpatrick; Jennifer Marcello; Katherine B Peters; David A Reardon; John H Sampson; Stevie Threatt; Henry S Friedman
The addition of bevacizumab to standard radiation therapy and temozolomide followed by bevacizumab, temozolomide, and irinotecan for newly diagnosed glioblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(12):4119-24.
2011: Faith G Davis; Dora Il'yasova; Kristin M Rankin; Bridget J McCarthy; Darell D Bigner
Medical diagnostic radiation exposures and risk of gliomas.
Radiation research 2011;175(6):790-6.
2011: David A Reardon; Scott Turner; Katherine B Peters; Annick Desjardins; Sridharan Gururangan; John H Sampson; Roger E McLendon; James E Herndon; Lee W Jones; John P Kirkpatrick; Allan H Friedman; James J Vredenburgh; Darell D Bigner; Henry S Friedman
A review of VEGF/VEGFR-targeted therapeutics for recurrent glioblastoma.
Journal of the National Comprehensive Cancer Network : JNCCN 2011;9(4):414-27.
2011: Ankit I Mehta; Ira Pastan; Raghu Raghavan; Darell D Bigner; Martin Brady; Bryan D Choi; Allan H Friedman; John H Sampson
Imaging of convection enhanced delivery of toxins in humans.
Toxins 2011;3(3):201-6.
2011: Ankit I Mehta; Darell D Bigner; Allan H Friedman; Charles W Kanaly; John H Sampson
Monitoring radiographic brain tumor progression.
Toxins 2011;3(3):191-200.
2011: John H Sampson; Kenneth Aldape; Gary E Archer; April Coan; Annick Desjardins; Allan H Friedman; Henry S Friedman; Mark R Gilbert; James E Herndon; Roger E McLendon; Duane A Mitchell; David A Reardon; Raymond Sawaya; Robert Schmittling; Weiming Shi; James J Vredenburgh; Darell D Bigner; Amy B Heimberger
Greater chemotherapy-induced lymphopenia enhances tumor-specific immune responses that eliminate EGFRvIII-expressing tumor cells in patients with glioblastoma.
Neuro-oncology 2011;13(3):324-33.
2011: Zachary J Reitman; Genglin Jin; Edward D Karoly; Ivan Spasojevic; Jian Yang; Kenneth W Kinzler; Yiping He; Darell D Bigner; Bert Vogelstein; Hai Yan
Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(8):3270-5.
2011: Bridget J McCarthy; Kristin M Rankin; Dora Il'yasova; Serap Erdal; Nicholas Vick; Francis Ali-Osman; Darell D Bigner; Faith G Davis
Assessment of type of allergy and antihistamine use in the development of glioma.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2011;20(2):370-8.
2011: Stephen T Keir; Mark W Dewhirst; John P Kirkpatrick; Darell D Bigner; Ines Batinic-Haberle
Cellular redox modulator, ortho Mn(III) meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin, MnTnHex-2-PyP(5+) in the treatment of brain tumors.
Anti-cancer agents in medicinal chemistry 2011;11(2):202-12.
2011: Genglin Jin; Zachary J Reitman; Ivan Spasojevic; Ines Batinic-Haberle; Jian Yang; Oleg Schmidt-Kittler; Darell D Bigner; Hai Yan
2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations.
PloS one 2011;6(2):e16812.
2011: Charles W Kanaly; Dale Ding; Ankit I Mehta; Anthony F Waller; Ian Crocker; Annick Desjardins; David A Reardon; Allan H Friedman; Darell D Bigner; John H Sampson
A novel method for volumetric MRI response assessment of enhancing brain tumors.
PloS one 2011;6(1):e16031.
2011: David A Reardon; James J Vredenburgh; Annick Desjardins; Katherine Peters; Sridharan Gururangan; John H Sampson; Jennifer Marcello; James E Herndon; Roger E McLendon; Dorothea Janney; Allan H Friedman; Darell D Bigner; Henry S Friedman
Effect of CYP3A-inducing anti-epileptics on sorafenib exposure: results of a phase II study of sorafenib plus daily temozolomide in adults with recurrent glioblastoma.
Journal of neuro-oncology 2011;101(1):57-66.
2010: Bo Cui; Francis Ali-Osman; Darell D Bigner; Nancy Bullock; Stewart P Johnson; Henry S Friedman
Decoupling of DNA damage response signaling from DNA damages underlies temozolomide resistance in glioblastoma cells.
Journal of biomedical research 2010;24(6):424-35.
2010: John H Sampson; Amy B Heimberger; Gary E Archer; Kenneth D Aldape; Allan H Friedman; Henry S Friedman; Mark R Gilbert; James E Herndon; Roger E McLendon; Duane A Mitchell; David A Reardon; Raymond Sawaya; Robert J Schmittling; Weiming Shi; James J Vredenburgh; Darell D Bigner
Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(31):4722-9.
2010: Yukinari Kato; Ganesan Vaidyanathan; Mika Kato Kaneko; Kazuhiko Mishima; Nidhi Srivastava; Vidyalakshmi Chandramohan; Charles N Pegram; Stephen T Keir; Chien-Tsun Kuan; Darell D Bigner; Michael R Zalutsky
Evaluation of anti-podoplanin rat monoclonal antibody NZ-1 for targeting malignant gliomas.
Nuclear medicine and biology 2010;37(7):785-94.
2010: Marc Hens; Ganesan Vaidyanathan; Xiao-Guang Zhao; Darell D Bigner; Michael R Zalutsky
Anti-EGFRvIII monoclonal antibody armed with 177Lu: in vivo comparison of macrocyclic and acyclic ligands.
Nuclear medicine and biology 2010;37(7):741-50.
2010: S E Wheeler; S Suzuki; Sufi Thomas; M Sen; R J Leeman-Neill; S I Chiosea; C-T Kuan; Darell D Bigner; William Gooding; Stephen Y Lai; Jennifer Rubin Grandis
Epidermal growth factor receptor variant III mediates head and neck cancer cell invasion via STAT3 activation.
Oncogene 2010;29(37):5135-45.
2010: Genglin Jin; Stephen Cook; Bo Cui; William C Chen; Stephen T Keir; Patrick Killela; Chunhui Di; Cathy A Payne; Simon G Gregory; Roger McLendon; Darell D Bigner; Hai Yan
HDMX regulates p53 activity and confers chemoresistance to 3-bis(2-chloroethyl)-1-nitrosourea.
Neuro-oncology 2010;12(9):956-66.
2010: Christopher G Duncan; Patrick J Killela; Cathy A Payne; Benjamin Lampson; William C Chen; Jeff Liu; David Solomon; Todd Waldman; Aaron J Towers; Simon G Gregory; Kerrie L McDonald; Roger E McLendon; Darell D Bigner; Hai Yan
Integrated genomic analyses identify ERRFI1 and TACC3 as glioblastoma-targeted genes.
Oncotarget 2010;1(4):265-77.
2010: Chien-Tsun Kuan; Nidhi Srivastava; Roger E McLendon; Wayne A Marasco; Michael R Zalutsky; Darell D Bigner
Recombinant single-chain variable fragment antibodies against extracellular epitopes of human multidrug resistance protein MRP3 for targeting malignant gliomas.
International journal of cancer. Journal international du cancer 2010;127(3):598-611.
2010: Giselle Y Lopez; Zachary J Reitman; David Solomon; Todd Waldman; Darell D Bigner; Roger E McLendon; STEVEN ROSENBERG; Yardena Samuels; Hai Yan
IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain.
Biochemical and biophysical research communications 2010;398(3):585-7.
2010: Zachary J Reitman; Natasha J Olby; Christopher L Mariani; Rachael Thomas; Matthew Breen; Darell D Bigner; Roger E McLendon; Hai Yan
IDH1 and IDH2 hotspot mutations are not found in canine glioma.
International journal of cancer. Journal international du cancer 2010;127(1):245-6.
2010: D Cory Adamson; Roger E McLendon; B Ahmed K Rasheed; Darell D Bigner
Central nervous system.
Cancer biomarkers : section A of Disease markers 2010;9(1-6):193-210.
2010: Chien-Tsun Kuan; Jinli Chang; Jan-Eric Mansson; Jianjun Li; Charles Pegram; Pam Fredman; Roger E McLendon; Darell D Bigner
Multiple phenotypic changes in mice after knockout of the B3gnt5 gene, encoding Lc3 synthase--a key enzyme in lacto-neolacto ganglioside synthesis.
BMC developmental biology 2010;10():114.
2010: Chien-Tsun Kuan; Kenji Wakiya; James E Herndon; Eric S Lipp; Charles N Pegram; Gregory J Riggins; Ahmed Rasheed; Scott E Szafranski; Roger E McLendon; Carol J Wikstrand; Darell D Bigner
MRP3: a molecular target for human glioblastoma multiforme immunotherapy.
BMC cancer 2010;10():468.
2010: David C Adamson; Qun Shi; Matthew Wortham; Paul A Northcott; Chunhui Di; Christopher G Duncan; Jianjun Li; Roger E McLendon; Darell D Bigner; Michael D Taylor; Hai Yan
OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas.
Cancer research 2010;70(1):181-91.
2010: Yukinari Kato; Chien-Tsun Kuan; Jinli Chang; Mika Kato Kaneko; Joanne Ayriss; Hailan Piao; Vidyalakshmi Chandramohan; Charles Pegram; Roger E McLendon; Pam Fredman; Jan-Eric Månsson; Darell D Bigner
GMab-1, a high-affinity anti-3'-isoLM1/3',6'-isoLD1 IgG monoclonal antibody, raised in lacto-series ganglioside-defective knockout mice.
Biochemical and biophysical research communications 2010;391(1):750-5.
2009: Yukinari Kato; Genglin Jin; Chien-Tsun Kuan; Roger E McLendon; Hai Yan; Darell D Bigner
A monoclonal antibody IMab-1 specifically recognizes IDH1R132H, the most common glioma-derived mutation.
Biochemical and biophysical research communications 2009;390(3):547-51.
2009: Hai Yan; Darell D Bigner; Victor E Velculescu; DONALD PARSONS
Mutant metabolic enzymes are at the origin of gliomas.
Cancer research 2009;69(24):9157-9.
2009: David A Reardon; Annick Desjardins; James J Vredenburgh; Sridharan Gururangan; John H Sampson; Sith Sathornsumetee; Roger E McLendon; James E Herndon; J E Marcello; J Norfleet; Allan H Friedman; Darell D Bigner; Henry S Friedman
Metronomic chemotherapy with daily, oral etoposide plus bevacizumab for recurrent malignant glioma: a phase II study.
British journal of cancer 2009;101(12):1986-94.
2009: Chien-Tsun Kuan; Carol J Wikstrand; Roger E McLendon; Michael R Zalutsky; Ujendra Kumar; Darell D Bigner
Detection of amino-terminal extracellular domain of somatostatin receptor 2 by specific monoclonal antibodies and quantification of receptor density in medulloblastoma.
Hybridoma (2005) 2009;28(6):389-403.
2009: Zheming Lu; Lei Zhou; Patrick Killela; Ahmed B Rasheed; Chunhui Di; William E Poe; Roger E McLendon; Darell D Bigner; Christopher Nicchitta; Hai Yan
Glioblastoma proto-oncogene SEC61gamma is required for tumor cell survival and response to endoplasmic reticulum stress.
Cancer research 2009;69(23):9105-11.
2009: John H Sampson; Gary E Archer; Duane A Mitchell; Amy B Heimberger; James E Herndon; Denise Lally-Goss; Sharon McGehee-Norman; Alison Paolino; David A Reardon; Allan H Friedman; Henry S Friedman; Darell D Bigner
An epidermal growth factor receptor variant III-targeted vaccine is safe and immunogenic in patients with glioblastoma multiforme.
Molecular cancer therapeutics 2009;8(10):2773-9.
2009: Bryan D Choi; Gary E Archer; Duane A Mitchell; Amy B Heimberger; Roger E McLendon; Darell D Bigner; John H Sampson
EGFRvIII-targeted vaccination therapy of malignant glioma.
Brain pathology (Zurich, Switzerland) 2009;19(4):713-23.
2009: Michael W Graner; Deborah A Raynes; Darell D Bigner; Vince Guerriero
Heat shock protein 70-binding protein 1 is highly expressed in high-grade gliomas, interacts with multiple heat shock protein 70 family members, and specifically binds brain tumor cell surfaces.
Cancer science 2009;100(10):1870-9.
2009: Meryem Bektas; Stewart P Johnson; William E Poe; Darell D Bigner; Henry S Friedman
A sphingosine kinase inhibitor induces cell death in temozolomide resistant glioblastoma cells.
Cancer chemotherapy and pharmacology 2009;64(5):1053-8.
2009: Jennifer A Quinn; Sara Xiaoyin Jiang; David A Reardon; Annick Desjardins; James J Vredenburgh; Jeremy Rich; Sridharan Gururangan; Allan H Friedman; Darell D Bigner; John H Sampson; Roger E McLendon; James E Herndon; Amy Walker; Henry S Friedman
Phase I trial of temozolomide plus O6-benzylguanine 5-day regimen with recurrent malignant glioma.
Neuro-oncology 2009;11(5):556-61.
2009: Abraham Boskovitz; Roger E McLendon; Tatsunori Okamura; John H Sampson; Darell D Bigner; Michael R Zalutsky
Treatment of HER2-positive breast carcinomatous meningitis with intrathecal administration of alpha-particle-emitting (211)At-labeled trastuzumab.
Nuclear medicine and biology 2009;36(6):659-69.
2009: Cory Adamson; Okezie O Kanu; Ankit I Mehta; Chunhui Di; Ningjing Lin; Austin K Mattox; Darell D Bigner
Glioblastoma multiforme: a review of where we have been and where we are going.
Expert opinion on investigational drugs 2009;18(8):1061-83.
2009: Mary Lou Affronti; Christopher R Heery; James E Herndon; Jeremy Rich; David A Reardon; Annick Desjardins; James J Vredenburgh; Allan H Friedman; Darell D Bigner; Henry S Friedman
Overall survival of newly diagnosed glioblastoma patients receiving carmustine wafers followed by radiation and concurrent temozolomide plus rotational multiagent chemotherapy.
Cancer 2009;115(15):3501-11.
2009: Okezie O Kanu; Ankit Mehta; Chunhui Di; Ningjing Lin; Kathy Bortoff; Darell D Bigner; Hai Yan; David Cory Adamson
Glioblastoma multiforme: a review of therapeutic targets.
Expert opinion on therapeutic targets 2009;13(6):701-18.
2009: B Cui; S P Johnson; N Bullock; F Ali-Osman; Darell D Bigner; H S Friedman
Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway.
Molecular pharmacology 2009;75(6):1356-63.
2009: Michael W Graner; Oscar Alzate; Angelika M Dechkovskaia; Jack D Keene; John H Sampson; Duane A Mitchell; Darell D Bigner
Proteomic and immunologic analyses of brain tumor exosomes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(5):1541-57.
2009: Dora Il'yasova; Bridget J McCarthy; Jennifer Marcello; Joellen M Schildkraut; Patricia G Moorman; Bhuma Krishnamachari; Francis Ali-Osman; Darell D Bigner; Faith G Davis
Association between glioma and history of allergies, asthma, and eczema: a case-control study with three groups of controls.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009;18(4):1232-8.
2009: Jennifer A Quinn; Sara Xiaoyin Jiang; David A Reardon; Annick Desjardins; James J Vredenburgh; Jeremy Rich; Sridharan Gururangan; Allan H Friedman; Darell D Bigner; John H Sampson; Roger E McLendon; James E Herndon; Amy Walker; Henry S Friedman
Phase II trial of temozolomide plus o6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(8):1262-7.
2009: Dora Il'yasova; Bridget J McCarthy; Serap Erdal; Joanna Shimek; Jennifer Goldstein; Daniel R Doerge; Steven R Myers; Paolo Vineis; John S Wishnok; James A Swenberg; Darell D Bigner; Faith G Davis
Human exposure to selected animal neurocarcinogens: a biomarker-based assessment and implications for brain tumor epidemiology.
Journal of toxicology and environmental health. Part B, Critical reviews 2009;12(3):175-87.
2009: Manny Bacolod; Randy Fehdrau; Stewart P Johnson; Nancy S Bullock; Darell D Bigner; Michael Colvin; Henry S Friedman
BCNU-sequestration by metallothioneins may contribute to resistance in a medulloblastoma cell line.
Cancer chemotherapy and pharmacology 2009;63(4):753-8.
2009: Hai Yan; DONALD PARSONS; Genglin Jin; Roger McLendon; B Ahmed Rasheed; Weishi Yuan; Ivan Kos; Ines Batinic-Haberle; Siân Jones; Gregory J Riggins; Henry Friedman; Allan Friedman; David Reardon; James Herndon; Kenneth W Kinzler; Victor E Velculescu; Bert Vogelstein; Darell D Bigner
IDH1 and IDH2 mutations in gliomas.
The New England journal of medicine 2009;360(8):765-73.
2009: Jennifer A Quinn; Sara Xiaoyin Jiang; James Carter; David A Reardon; Annick Desjardins; James J Vredenburgh; Jeremy Rich; Sridharan Gururangan; Allan H Friedman; Darell D Bigner; John H Sampson; Roger E McLendon; James E Herndon; Stevie Threatt; Henry S Friedman
Phase II trial of Gliadel plus O6-benzylguanine in adults with recurrent glioblastoma multiforme.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(3):1064-8.
2009: Yingmiao Liu; Chien-Tsun Kuan; Jing Mi; Xiuwu Zhang; Bryan M Clary; Darell D Bigner; Bruce A Sullenger
Aptamers selected against the unglycosylated EGFRvIII ectodomain and delivered intracellularly reduce membrane-bound EGFRvIII and induce apoptosis.
Biological chemistry 2009;390(2):137-44.
2008: Robert J Schmittling; Gary E Archer; Duane A Mitchell; Amy B Heimberger; Charles N Pegram; James E Herndon; Henry S Friedman; Darell D Bigner; John H Sampson
Detection of humoral response in patients with glioblastoma receiving EGFRvIII-KLH vaccines.
Journal of immunological methods 2008;339(1):74-81.
2008: Annick Desjardins; David A Reardon; James E Herndon; Jennifer Marcello; Jennifer A Quinn; Jeremy Rich; Sith Sathornsumetee; Sridharan Gururangan; John Sampson; Leighann Bailey; Darell D Bigner; Allan H Friedman; Henry S Friedman; James J Vredenburgh
Bevacizumab plus irinotecan in recurrent WHO grade 3 malignant gliomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(21):7068-73.
2008: John H Sampson; Gary E Archer; Duane A Mitchell; Amy B Heimberger; Darell D Bigner
Tumor-specific immunotherapy targeting the EGFRvIII mutation in patients with malignant glioma.
Seminars in immunology 2008;20(5):267-75.
2008: Jill A Maxwell; Stewart P Johnson; Roger E McLendon; David W Lister; Krystle S Horne; Ahmed Rasheed; Jennifer A Quinn; Francis Ali-Osman; Allan H Friedman; Paul Modrich; Darell D Bigner; Henry S Friedman
Mismatch repair deficiency does not mediate clinical resistance to temozolomide in malignant glioma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(15):4859-68.
2008: John H Sampson; Gamal Akabani; Gary E Archer; Mitchel S Berger; R Edward Coleman; Allan H Friedman; Henry S Friedman; Kim Greer; James E Herndon; Sandeep Kunwar; Roger E McLendon; Alison Paolino; Neil Petry; James M Provenzale; David A Reardon; Terence Z Wong; Michael R Zalutsky; Ira Pastan; Darell D Bigner
Intracerebral infusion of an EGFR-targeted toxin in recurrent malignant brain tumors.
Neuro-oncology 2008;10(3):320-9.
2008: Manny Bacolod; Simon M Lin; Stewart P Johnson; Nancy S Bullock; Michael Colvin; Darell D Bigner; Henry S Friedman
The gene expression profiles of medulloblastoma cell lines resistant to preactivated cyclophosphamide.
Current cancer drug targets 2008;8(3):172-9.
2008: Richard G Everson; Michael W Graner; Matthias Gromeier; James J Vredenburgh; Annick Desjardins; David A Reardon; Henry S Friedman; Allan H Friedman; Darell D Bigner; John H Sampson
Immunotherapy against angiogenesis-associated targets: evidence and implications for the treatment of malignant glioma.
Expert review of anticancer therapy 2008;8(5):717-32.
2008: David A Reardon; Michael R Zalutsky; Gamal Akabani; R Edward Coleman; Allan H Friedman; James E Herndon; Roger E McLendon; Charles N Pegram; Jennifer A Quinn; Jeremy Rich; James J Vredenburgh; Annick Desjardins; Sridharan Guruangan; Susan Boulton; Renee H Raynor; Jeannette M Dowell; Terence Z Wong; Xiao-Guang Zhao; Henry S Friedman; Darell D Bigner
A pilot study: 131I-antitenascin monoclonal antibody 81c6 to deliver a 44-Gy resection cavity boost.
Neuro-oncology 2008;10(2):182-9.
2008: Ryan T Mott; Kristi C Turner; Darell D Bigner; Roger E McLendon
Utility of EGFR and PTEN numerical aberrations in the evaluation of diffusely infiltrating astrocytomas. Laboratory investigation.
Journal of neurosurgery 2008;108(2):330-5.
2008: Amy B Heimberger; Wei Sun; S Farzana Hussain; Mahua Dey; Lamonne Crutcher; Kenneth Aldape; Mark Gilbert; Samuel J Hassenbusch; Raymond Sawaya; Bob Schmittling; Gary E Archer; Duane A Mitchell; Darell D Bigner; John H Sampson
Immunological responses in a patient with glioblastoma multiforme treated with sequential courses of temozolomide and immunotherapy: case study.
Neuro-oncology 2008;10(1):98-103.
2008: Koji Yoshimoto; Julie Dang; Shaojun Zhu; David Nathanson; Tiffany Huang; Rebecca Dumont; David Seligson; William H Yong; Zhenggang Xiong; Nagesh Rao; Henrik Winther; Arnab Chakravarti; Darell D Bigner; Ingo K Mellinghoff; Steve Horvath; Webster K Cavenee; Timothy F Cloughesy; Paul S Mischel
Development of a real-time RT-PCR assay for detecting EGFRvIII in glioblastoma samples.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(2):488-93.
2008: Michael R Zalutsky; David A Reardon; Gamal Akabani; R Edward Coleman; Allan H Friedman; Henry S Friedman; Roger E McLendon; Terence Z Wong; Darell D Bigner
Clinical experience with alpha-particle emitting 211At: treatment of recurrent brain tumor patients with 211At-labeled chimeric antitenascin monoclonal antibody 81C6.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2008;49(1):30-8.
2008: Hidenobu Ochiai; Gary E Archer; James E Herndon; Chien-Tsun Kuan; Duane A Mitchell; Darell D Bigner; Ira Pastan; John H Sampson
EGFRvIII-targeted immunotoxin induces antitumor immunity that is inhibited in the absence of CD4+ and CD8+ T cells.
Cancer immunology, immunotherapy : CII 2008;57(1):115-21.
2007: Stewart P Johnson; Barton A. Kamen; Darell D Bigner; Henry S Friedman
O (4)-benzylfolic acid inactivates O (6)-alkylguanine-DNA alkyltransferase in brain tumor cell lines.
Cancer chemotherapy and pharmacology 2007;60(6):883-9.
2007: James J Vredenburgh; Annick Desjardins; James E Herndon; Jennifer Marcello; David A Reardon; Jennifer A Quinn; Jeremy Rich; Sith Sathornsumetee; Sridharan Gururangan; John Sampson; Melissa Wagner; Leighann Bailey; Darell D Bigner; Allan H Friedman; Henry S Friedman
Bevacizumab plus irinotecan in recurrent glioblastoma multiforme.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(30):4722-9.
2007: Michael W Graner; R Ian Cumming; Darell D Bigner
The heat shock response and chaperones/heat shock proteins in brain tumors: surface expression, release, and possible immune consequences.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(42):11214-27.
2007: Michael R Zalutsky; David A Reardon; Oscar R Pozzi; Ganesan Vaidyanathan; Darell D Bigner
Targeted alpha-particle radiotherapy with 211At-labeled monoclonal antibodies.
Nuclear medicine and biology 2007;34(7):779-85.
2007: Anita B Hjelmeland; Kathryn P Lattimore; Brian E Fee; Qing Shi; Sarah Wickman; Stephen T Keir; Mark D Hjelmeland; David Batt; Darell D Bigner; Henry S Friedman; Jeremy Rich
The combination of novel low molecular weight inhibitors of RAF (LBT613) and target of rapamycin (RAD001) decreases glioma proliferation and invasion.
Molecular cancer therapeutics 2007;6(9):2449-57.
2007: Michael A Badruddoja; Stephen T Keir; Ivan King; Joseph Zeidner; James J Vredenburgh; Lawrence H Muhlbaier; Darell D Bigner; Henry S Friedman
Activity of VNP40101M (Cloretazine) in the treatment of CNS tumor xenografts in athymic mice.
Neuro-oncology 2007;9(3):240-4.
2007: John H Sampson; Raghu Raghavan; Martin L Brady; James M Provenzale; James E Herndon; David Croteau; Allan H Friedman; David A Reardon; R Edward Coleman; Terence Wong; Darell D Bigner; Ira Pastan; María Inmaculada Rodríguez-Ponce; Philipp Tanner; Raj Puri; Christoph Pedain
Clinical utility of a patient-specific algorithm for simulating intracerebral drug infusions.
Neuro-oncology 2007;9(3):343-53.
2007: Qing Shi; Shideng Bao; L Song; Qiulian Wu; Darell D Bigner; Anita B Hjelmeland; Jeremy Rich
Targeting SPARC expression decreases glioma cellular survival and invasion associated with reduced activities of FAK and ILK kinases.
Oncogene 2007;26(28):4084-94.
2007: Qing Shi; Anita B Hjelmeland; Stephen T Keir; Linhua Song; Sarah Wickman; Dowdy Jackson; Osamu Ohmori; Darell D Bigner; Henry S Friedman; Jeremy Rich
A novel low-molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth.
Molecular carcinogenesis 2007;46(6):488-96.
2007: Roger E McLendon; Gamal Akabani; Henry S Friedman; David A Reardon; Linda Cleveland; Ilkcan Cokgor; James E Herndon; Carol J Wikstrand; Susan T Boulton; Allan H Friedman; Darell D Bigner; Michael R Zalutsky
Tumor resection cavity administered iodine-131-labeled antitenascin 81C6 radioimmunotherapy in patients with malignant glioma: neuropathology aspects.
Nuclear medicine and biology 2007;34(4):405-13.
2007: David A Reardon; Michael R Zalutsky; Darell D Bigner
Antitenascin-C monoclonal antibody radioimmunotherapy for malignant glioma patients.
Expert review of anticancer therapy 2007;7(5):675-87.
2007: Peter E Fecci; Hidenobu Ochiai; Duane A Mitchell; Peter M Grossi; Alison E Sweeney; Gary E Archer; Thomas J Cummings; James P Allison; Darell D Bigner; John H Sampson
Systemic CTLA-4 blockade ameliorates glioma-induced changes to the CD4+ T cell compartment without affecting regulatory T-cell function.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(7):2158-67.
2007: Lee W Jones; Bebe Guill; Stephen T Keir; Karen Carter; Henry S Friedman; Darell D Bigner; David A Reardon
Using the theory of planned behavior to understand the determinants of exercise intention in patients diagnosed with primary brain cancer.
Psycho-oncology 2007;16(3):232-40.
2007: James J Vredenburgh; Annick Desjardins; James E Herndon; Jeannette M Dowell; David A Reardon; Jennifer A Quinn; Jeremy Rich; Sith Sathornsumetee; Sridharan Gururangan; Melissa Wagner; Darell D Bigner; Allan H Friedman; Henry S Friedman
Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(4):1253-9.
2007: Alexander T Yordanov; Marc Hens; Charles N Pegram; Darell D Bigner; Michael R Zalutsky
Antitenascin antibody 81C6 armed with 177Lu: in vivo comparison of macrocyclic and acyclic ligands.
Nuclear medicine and biology 2007;34(2):173-83.
2007: John H Sampson; Martin L Brady; Neil Petry; David Croteau; Allan H Friedman; Henry S Friedman; Terence Wong; Darell D Bigner; Ira Pastan; Raj K Puri; Christoph Pedain
Intracerebral infusate distribution by convection-enhanced delivery in humans with malignant gliomas: descriptive effects of target anatomy and catheter positioning.
Neurosurgery 2007;60(2 Suppl 1):ONS89-98; discussion ONS98-9.
2007: Michael A Badruddoja; Kara Penne; Annick Desjardins; David A Reardon; Jeremy Rich; Jennifer A Quinn; Sith Sathornsumetee; Allan H Friedman; Darell D Bigner; James E Herndon; Ann Cahill; Henry S Friedman; James J Vredenburgh
Phase II study of Cloretazine for the treatment of adults with recurrent glioblastoma multiforme.
Neuro-oncology 2007;9(1):70-4.
2007: Lee W Jones; Bebe Guill; Stephen T Keir; Karen Carter; Henry S Friedman; Darell D Bigner; David A Reardon
Exercise interest and preferences among patients diagnosed with primary brain cancer.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2007;15(1):47-55.
2006: Shideng Bao; Qiulian Wu; Roger E McLendon; Yueling Hao; Qing Shi; Anita B Hjelmeland; Mark Dewhirst; Darell D Bigner; Jeremy Rich
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response.
Nature 2006;444(7120):756-60.
2006: Jill A Maxwell; Stewart P Johnson; Jennifer A Quinn; Roger E McLendon; Francis Ali-Osman; Allan H Friedman; James E Herndon; Katja Bierau; Joseph Bigley; Darell D Bigner; Henry S Friedman
Quantitative analysis of O6-alkylguanine-DNA alkyltransferase in malignant glioma.
Molecular cancer therapeutics 2006;5(10):2531-9.
2006: John C Sok; Francesca M Coppelli; Sufi Thomas; Miriam N Lango; Sichuan Xi; Jennifer L Hunt; Maria L Freilino; Michael W Graner; Carol J Wikstrand; Darell D Bigner; William Gooding; Frank B Furnari; Jennifer Rubin Grandis
Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(17):5064-73.
2006: Sith Sathornsumetee; Anita B Hjelmeland; Stephen T Keir; Roger E McLendon; David Batt; Timothy Ramsey; Naeem Yusuff; B K Ahmed Rasheed; Mark W Kieran; Andrea Laforme; Darell D Bigner; Henry S Friedman; Jeremy Rich
AAL881, a novel small molecule inhibitor of RAF and vascular endothelial growth factor receptor activities, blocks the growth of malignant glioma.
Cancer research 2006;66(17):8722-30.
2006: Shideng Bao; Qiulian Wu; Sith Sathornsumetee; Yueling Hao; Zhizhong Li; Anita B Hjelmeland; Qing Shi; Roger E McLendon; Darell D Bigner; Jeremy Rich
Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor.
Cancer research 2006;66(16):7843-8.
2006: Peter E Fecci; Alison E Sweeney; Peter M Grossi; Smita K Nair; Chris A Learn; Duane A Mitchell; Xiuyu Cui; Thomas J Cummings; Darell D Bigner; Eli Gilboa; John H Sampson
Systemic anti-CD25 monoclonal antibody administration safely enhances immunity in murine glioma without eliminating regulatory T cells.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(14 Pt 1):4294-305.
2006: Ganesan Vaidyanathan; Kevin L Alston; Darell D Bigner; Michael R Zalutsky
Nepsilon-(3-[*I]Iodobenzoyl)-Lys5-Nalpha-maleimido-Gly1-GEEEK ([*I]IB-Mal-D-GEEEK): a radioiodinated prosthetic group containing negatively charged D-glutamates for labeling internalizing monoclonal antibodies.
Bioconjugate chemistry 2006;17(4):1085-92.
2006: David A Reardon; Jennifer A Quinn; Gamal Akabani; R Edward Coleman; Allan H Friedman; Henry S Friedman; James E Herndon; Roger E McLendon; Charles N Pegram; James M Provenzale; Jeannette M Dowell; Jeremy Rich; James J Vredenburgh; Annick Desjardins; John H Sampson; Sridharan Gururangan; Terence Z Wong; Michael A Badruddoja; Xiao-Guang Zhao; Darell D Bigner; Michael R Zalutsky
Novel human IgG2b/murine chimeric antitenascin monoclonal antibody construct radiolabeled with 131I and administered into the surgically created resection cavity of patients with malignant glioma: phase I trial results.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2006;47(6):912-8.
2006: Lee W Jones; Bebe Guill; Stephen T Keir; Karen Carter B S; Henry S Friedman; Darell D Bigner; David A Reardon
Patterns of exercise across the cancer trajectory in brain tumor patients.
Cancer 2006;106(10):2224-32.
2006: Michael W Graner; Darell D Bigner
Therapeutic aspects of chaperones/heat-shock proteins in neuro-oncology.
Expert review of anticancer therapy 2006;6(5):679-95.
2006: Chien-Tsun Kuan; Kenji Wakiya; Jeannette M Dowell; James E Herndon; David A Reardon; Michael W Graner; Gregory J Riggins; Carol J Wikstrand; Darell D Bigner
Glycoprotein nonmetastatic melanoma protein B, a potential molecular therapeutic target in patients with glioblastoma multiforme.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(7 Pt 1):1970-82.
2006: Peter E Fecci; Duane A Mitchell; John F Whitesides; Weihua Xie; Allan H Friedman; Gary E Archer; James E Herndon; Darell D Bigner; Glenn Dranoff; John H Sampson
Increased regulatory T-cell fraction amidst a diminished CD4 compartment explains cellular immune defects in patients with malignant glioma.
Cancer research 2006;66(6):3294-302.
2006: David A Reardon; Jeremy Rich; Henry S Friedman; Darell D Bigner
Recent advances in the treatment of malignant astrocytoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(8):1253-65.
2006: David A Reardon; Jennifer A Quinn; James J Vredenburgh; Sridharan Gururangan; Allan H Friedman; Annick Desjardins; Sith Sathornsumetee; James E Herndon; Jeannette M Dowell; Roger E McLendon; James M Provenzale; John H Sampson; Robert P Smith; Alan J Swaisland; Judith S Ochs; Peggy Lyons; Sandy Tourt-Uhlig; Darell D Bigner; Henry S Friedman; Jeremy Rich
Phase 1 trial of gefitinib plus sirolimus in adults with recurrent malignant glioma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(3 Pt 1):860-8.
2006: John H Sampson; Gamal Akabani; Allan H Friedman; Darell D Bigner; Sandeep Kunwar; Mitchel S Berger; Krystof S Bankiewicz
Comparison of intratumoral bolus injection and convection-enhanced delivery of radiolabeled antitenascin monoclonal antibodies.
Neurosurgical focus 2006;20(4):E14.
2006: Faith G Davis; Serap Erdal; Lori Williams; Darell D Bigner
Work exposures to animal neurocarcinogens.
International journal of occupational and environmental health 2006;12(1):16-23.
2006: Sriram Shankar; Ganesan Vaidyanathan; Chien-Tsun Kuan; Darell D Bigner; Michael R Zalutsky
Antiepidermal growth factor variant III scFv fragment: effect of radioiodination method on tumor targeting and normal tissue clearance.
Nuclear medicine and biology 2006;33(1):101-10.
2006: David A Reardon; Gamal Akabani; R Edward Coleman; Allan H Friedman; Henry S Friedman; James E Herndon; Roger E McLendon; Charles N Pegram; James M Provenzale; Jennifer A Quinn; Jeremy Rich; James J Vredenburgh; Annick Desjardins; Sridharan Gururangan; Sri Guruangan; Michael A Badruddoja; Jeannette M Dowell; Terence Z Wong; Xiao-Guang Zhao; Michael R Zalutsky; Darell D Bigner
Salvage radioimmunotherapy with murine iodine-131-labeled antitenascin monoclonal antibody 81C6 for patients with recurrent primary and metastatic malignant brain tumors: phase II study results.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(1):115-22.
2005: Anita B Hjelmeland; Mark D Hjelmeland; Qing Shi; Janet L Hart; Darell D Bigner; Xiao-Fan Wang; Christopher D Kontos; Jeremy Rich
Loss of phosphatase and tensin homologue increases transforming growth factor beta-mediated invasion with enhanced SMAD3 transcriptional activity.
Cancer research 2005;65(24):11276-81.
2005: Keisuke Yamaguchi; Mark D Richardson; Darell D Bigner; Madan M Kwatra
Signal transduction through substance P receptor in human glioblastoma cells: roles for Src and PKCdelta.
Cancer chemotherapy and pharmacology 2005;56(6):585-93.
2005: Jeremy Rich; Sith Sathornsumetee; Stephen T Keir; Mark W Kieran; Andrea Laforme; Arja Kaipainen; Roger E McLendon; Michael W Graner; B K Ahmed Rasheed; Ling Wang; David A Reardon; Anderson Ryan; Catherine Wheeler; Isaiah Dimery; Darell D Bigner; Henry S Friedman
ZD6474, a novel tyrosine kinase inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor, inhibits tumor growth of multiple nervous system tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(22):8145-57.
2005: Henry S Friedman; Darell D Bigner
Glioblastoma multiforme and the epidermal growth factor receptor.
The New England journal of medicine 2005;353(19):1997-9.
2005: Roger E McLendon; James E Herndon; Bryan West; David Reardon; Rodney N Wiltshire; B K Ahmed Rasheed; Jennifer Quinn; Henry S Friedman; Allan H Friedman; Darell D Bigner
Survival analysis of presumptive prognostic markers among oligodendrogliomas.
Cancer 2005;104(8):1693-9.
2005: Susan M Chang; Sharon L Reynolds; Nicholas Butowski; Kathleen R Lamborn; Jan C Buckner; Richard S. Kaplan; Darell D Bigner
GNOSIS: guidelines for neuro-oncology: standards for investigational studies-reporting of phase 1 and phase 2 clinical trials.
Neuro-oncology 2005;7(4):425-34.
2005: David A Rizzieri; Martha Wadleigh; Carol J Wikstrand; Karen P Mann; Filiz Sen; Bercedis L Peterson; Donna Niedzwiecki; Alan D Proia; Darell D Bigner
Tenascin and microvessel stromal changes in patients with non-Hodgkin's lymphoma are isolated to the sites of disease and vary in correlation to disease activity.
Leukemia & lymphoma 2005;46(10):1455-62.
2005: Jennifer A Quinn; Annick Desjardins; Jon D Weingart; Henry Brem; M Eileen Dolan; Shannon M Delaney; James J Vredenburgh; Jeremy Rich; Allan H Friedman; David A Reardon; John H Sampson; Anthony E Pegg; Robert C Moschel; Robert Birch; Roger E McLendon; James M Provenzale; Sridharan Gururangan; Janet E Dancey; Jill Maxwell; Sandra Tourt-Uhlig; James E Herndon; Darell D Bigner; Henry S Friedman
Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(28):7178-87.
2005: C Lynn Cheng; Stewart P Johnson; Stephen T Keir; Jennifer A Quinn; Francis Ali-Osman; Csaba Szabó; Hongshan Li; Andrew L Salzman; M Eileen Dolan; Paul Modrich; Darell D Bigner; Henry S Friedman
Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft.
Molecular cancer therapeutics 2005;4(9):1364-8.
2005: Michael W Graner; Darell D Bigner
Chaperone proteins and brain tumors: potential targets and possible therapeutics.
Neuro-oncology 2005;7(3):260-78.
2005: Gamal Akabani; David A Reardon; R Edward Coleman; Terence Z Wong; Scott D Metzler; James Bowsher; Daniel P Barboriak; James M Provenzale; Kim L Greer; David DeLong; Henry S Friedman; Allan H Friedman; Xiao-Guang Zhao; Charles N Pegram; Roger E McLendon; Darell D Bigner; Michael R Zalutsky
Dosimetry and radiographic analysis of 131I-labeled anti-tenascin 81C6 murine monoclonal antibody in newly diagnosed patients with malignant gliomas: a phase II study.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2005;46(6):1042-51.
2005: Jeremy Rich; Christopher Hans; Beatrix Jones; Edwin S Iversen; Roger E McLendon; B K Ahmed Rasheed; Adrian Dobra; Holly K Dressman; Darell D Bigner; Joseph R Nevins; Mike West
Gene expression profiling and genetic markers in glioblastoma survival.
Cancer research 2005;65(10):4051-8.
2005: Chunhui Di; Shaoxi Liao; David C Adamson; Timothy J Parrett; Daniel K Broderick; Qun Shi; Christoph Lengauer; Jordan M Cummins; Victor E Velculescu; Daniel W Fults; Roger E McLendon; Darell D Bigner; Hai Yan
Identification of OTX2 as a medulloblastoma oncogene whose product can be targeted by all-trans retinoic acid.
Cancer research 2005;65(3):919-24.
2005: Annick Desjardins; Jeremy Rich; Jennifer A Quinn; James J Vredenburgh; Sridharan Gururangan; Sith Sathornsumetee; David A Reardon; Allan H Friedman; Darell D Bigner; Henry S Friedman
Chemotherapy and novel therapeutic approaches in malignant glioma.
Frontiers in bioscience : a journal and virtual library 2005;10():2645-68.
2005: John H Sampson; David A Reardon; Allan H Friedman; Henry S Friedman; R Edward Coleman; Roger E McLendon; Ira Pastan; Darell D Bigner
Sustained radiographic and clinical response in patient with bifrontal recurrent glioblastoma multiforme with intracerebral infusion of the recombinant targeted toxin TP-38: case study.
Neuro-oncology 2005;7(1):90-6.
2005: Ranjit K Goudar; Qing Shi; Mark D Hjelmeland; Stephen T Keir; Roger E McLendon; Carol J Wikstrand; Elizabeth D Reese; Charles A Conrad; Peter Traxler; Heidi A Lane; David A Reardon; Webster K Cavenee; Xiao-Fan Wang; Darell D Bigner; Henry S Friedman; Jeremy Rich
Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition.
Molecular cancer therapeutics 2005;4(1):101-12.
2005: Kalpaj Parekh; Sabarinathan Ramachandran; Joel Cooper; Darell D Bigner; Alexander Patterson; Thalachallour Mohanakumar
Tenascin-C, over expressed in lung cancer down regulates effector functions of tumor infiltrating lymphocytes.
Lung cancer (Amsterdam, Netherlands) 2005;47(1):17-29.
2004: Qing Shi; Shideng Bao; Jill A Maxwell; Elizabeth D Reese; Henry S Friedman; Darell D Bigner; Xiao-Fan Wang; Jeremy Rich
Secreted protein acidic, rich in cysteine (SPARC), mediates cellular survival of gliomas through AKT activation.
The Journal of biological chemistry 2004;279(50):52200-9.
2004: Enkhtsetseg Purev; Dewei Cai; Eric Miller; Rolf Swoboda; Ted Mayer; Andres Klein-Szanto; Francesco M Marincola; Rosemarie Mick; Laszlo Otvos; William H Wunner; Brigitte Birebent; Rajasekharan Somasundaram; Carol J Wikstrand; Darell D Bigner; Angela DeMichele; Geza Acs; Jesse A Berlin; Dorothee Herlyn
Immune responses of breast cancer patients to mutated epidermal growth factor receptor (EGF-RvIII, Delta EGF-R, and de2-7 EGF-R).
Journal of immunology (Baltimore, Md. : 1950) 2004;173(10):6472-80.
2004: Sriram Shankar; Ganesan Vaidyanathan; Donna J Affleck; Katia Peixoto; Darell D Bigner; Michael R Zalutsky
Evaluation of an internalizing monoclonal antibody labeled using N-succinimidyl 3-[131I]iodo-4-phosphonomethylbenzoate ([131I]SIPMB), a negatively charged substituent bearing acylation agent.
Nuclear medicine and biology 2004;31(7):909-19.
2004: Manny Bacolod; Stewart P Johnson; Anthony E Pegg; M Eileen Dolan; Robert C Moschel; Nancy S Bullock; Qingming Fang; O Michael Colvin; Paul Modrich; Darell D Bigner; Henry S Friedman
Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations.
Molecular cancer therapeutics 2004;3(9):1127-35.
2004: Abraham Boskovitz; Carol J Wikstrand; Chien-Tsun Kuan; Michael R Zalutsky; David A Reardon; Darell D Bigner
Monoclonal antibodies for brain tumour treatment.
Expert opinion on biological therapy 2004;4(9):1453-71.
2004: Daniel K Broderick; Chunhui Di; Timothy J Parrett; Yardena Samuels; Jordan M Cummins; Roger E McLendon; Daniel W Fults; Victor E Velculescu; Darell D Bigner; Hai Yan
Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas.
Cancer research 2004;64(15):5048-50.
2004: Rodney N Wiltshire; James E Herndon; Annie Lloyd; Henry S Friedman; Darell D Bigner; Sandra H Bigner; Roger E McLendon
Comparative genomic hybridization analysis of astrocytomas: prognostic and diagnostic implications.
The Journal of molecular diagnostics : JMD 2004;6(3):166-79.
2004: David A Rizzieri; Gamal Akabani; Michael R Zalutsky; R Edward Coleman; Scott D Metzler; James Bowsher; Bonnie Toaso; Elizabeth Anderson; Anand S Lagoo; Steve Clayton; Charles N Pegram; Joseph O Moore; Jon P Gockerman; Carlos M DeCastro; Cristina Gasparetto; Nelson J Chao; Darell D Bigner
Phase 1 trial study of 131I-labeled chimeric 81C6 monoclonal antibody for the treatment of patients with non-Hodgkin lymphoma.
Blood 2004;104(3):642-8.
2004: Melinda K Merrill; Günter Bernhardt; John H Sampson; Carol J Wikstrand; Darell D Bigner; Matthias Gromeier
Poliovirus receptor CD155-targeted oncolysis of glioma.
Neuro-oncology 2004;6(3):208-17.
2004: Mark D Hjelmeland; Anita B Hjelmeland; Sith Sathornsumetee; Elizabeth D Reese; Michael H Herbstreith; Nicholas J Laping; Henry S Friedman; Darell D Bigner; Xiao-Fan Wang; Jeremy Rich
SB-431542, a small molecule transforming growth factor-beta-receptor antagonist, inhibits human glioma cell line proliferation and motility.
Molecular cancer therapeutics 2004;3(6):737-45.
2004: Jeremy Rich; Darell D Bigner
Development of novel targeted therapies in the treatment of malignant glioma.
Nature reviews. Drug discovery 2004;3(5):430-46.
2004: Chris A Learn; Tristan L Hartzell; Carol J Wikstrand; Gary E Archer; Jeremy Rich; Allan H Friedman; Henry S Friedman; Darell D Bigner; John H Sampson
Resistance to tyrosine kinase inhibition by mutant epidermal growth factor receptor variant III contributes to the neoplastic phenotype of glioblastoma multiforme.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(9):3216-24.
2004: Jennifer A Quinn; David A Reardon; Allan H Friedman; Jeremy Rich; John H Sampson; James J Vredenburgh; Sridharan Gururangan; James M Provenzale; Amy Walker; Holly Schweitzer; Darell D Bigner; Sandra Tourt-Uhlig; James E Herndon; Mary Lou Affronti; Susanne Jackson; Deborah Allen; Karen Ziegler; Cindy Bohlin; Christy Lentz; Henry S Friedman
Phase 1 trial of irinotecan plus BCNU in patients with progressive or recurrent malignant glioma.
Neuro-oncology 2004;6(2):145-53.
2004: David A Reardon; Jennifer A Quinn; Jeremy Rich; Sridharan Gururangan; James J Vredenburgh; John H Sampson; James M Provenzale; Amy Walker; Michael A Badruddoja; Sandra Tourt-Uhlig; James E Herndon; Jeannette M Dowell; Mary Lou Affronti; Susanne Jackson; Deborah Allen; Karen Ziegler; Steven Silverman; Cindy Bohlin; Allan H Friedman; Darell D Bigner; Henry S Friedman
Phase 2 trial of BCNU plus irinotecan in adults with malignant glioma.
Neuro-oncology 2004;6(2):134-44.
2004: Abraham Boskovitz; Gamal Akabani; Charles N Pegram; Darell D Bigner; Michael R Zalutsky
Human/murine chimeric 81C6 F(ab')(2) fragment: preclinical evaluation of a potential construct for the targeted radiotherapy of malignant glioma.
Nuclear medicine and biology 2004;31(3):345-55.
2004: Monette S Castillo; Faith G Davis; Tanya Surawicz; Janet M Bruner; Sandra Bigner; Stephen Coons; Darell D Bigner
Consistency of primary brain tumor diagnoses and codes in cancer surveillance systems.
Neuroepidemiology 2004;23(1-2):85-93.
2004: Jeremy Rich; David A Reardon; Terry Peery; Jeannette M Dowell; Jennifer A Quinn; Kara Penne; Carol J Wikstrand; Lauren B Van Duyn; Janet E Dancey; Roger E McLendon; James C Kao; Timothy T Stenzel; B K Ahmed Rasheed; Sandra Tourt-Uhlig; James E Herndon; James J Vredenburgh; John H Sampson; Allan H Friedman; Darell D Bigner; Henry S Friedman
Phase II trial of gefitinib in recurrent glioblastoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(1):133-42.
2003: Peter M Grossi; Hidenobu Ochiai; Gary E Archer; Roger E McLendon; Michael R Zalutsky; Allan H Friedman; Henry S Friedman; Darell D Bigner; John H Sampson
Efficacy of intracerebral microinfusion of trastuzumab in an athymic rat model of intracerebral metastatic breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(15):5514-20.
2003: John H Sampson; Gamal Akabani; Gary E Archer; Darell D Bigner; Mitchel S Berger; Allan H Friedman; Henry S Friedman; James E Herndon; Sandeep Kunwar; Steve Marcus; Roger E McLendon; Alison Paolino; Kara Penne; James M Provenzale; Jennifer Quinn; David A Reardon; Jeremy Rich; Timothy T Stenzel; Sandra Tourt-Uhlig; Carol J Wikstrand; Terence Wong; Roger Williams; Fan Yuan; Michael R Zalutsky; Ira Pastan
Progress report of a Phase I study of the intracerebral microinfusion of a recombinant chimeric protein composed of transforming growth factor (TGF)-alpha and a mutated form of the Pseudomonas exotoxin termed PE-38 (TP-38) for the treatment of malignant brain tumors.
Journal of neuro-oncology 2003;65(1):27-35.
2003: Amy B Heimberger; Laura E Crotty; Gary E Archer; Kenneth R Hess; Carol J Wikstrand; Allan H Friedman; Henry S Friedman; Darell D Bigner; John H Sampson
Epidermal growth factor receptor VIII peptide vaccination is efficacious against established intracerebral tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(11):4247-54.
2003: Peter E Fecci; Duane A Mitchell; Gary E Archer; Michael A Morse; H Kim Lyerly; Darell D Bigner; John H Sampson
The history, evolution, and clinical use of dendritic cell-based immunization strategies in the therapy of brain tumors.
Journal of neuro-oncology 2003;64(1-2):161-76.
2003: Jeremy Rich; Qing Shi; Mark D Hjelmeland; Thomas J Cummings; Chien-Tsun Kuan; Darell D Bigner; Christopher M Counter; Xiao-Fan Wang
Bone-related genes expressed in advanced malignancies induce invasion and metastasis in a genetically defined human cancer model.
The Journal of biological chemistry 2003;278(18):15951-7.
2003: Ganesan Vaidyanathan; Donna J Affleck; Darell D Bigner; Michael R Zalutsky
N-succinimidyl 3-[211At]astato-4-guanidinomethylbenzoate: an acylation agent for labeling internalizing antibodies with alpha-particle emitting 211At.
Nuclear medicine and biology 2003;30(4):351-9.
2003: Jennifer A Quinn; David A Reardon; Allan H Friedman; Jeremy Rich; John H Sampson; James M Provenzale; Roger E McLendon; Sridharan Gururangan; Darell D Bigner; James E Herndon; Nicholas Avgeropoulos; Jonathan Lester Finlay; Sandra Tourt-Uhlig; Mary Lou Affronti; Brandon Evans; Valerie Stafford-Fox; Sara Zaknoen; Henry S Friedman
Phase II trial of temozolomide in patients with progressive low-grade glioma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003;21(4):646-51.
2002: Gamal Akabani; Roger E McLendon; Darell D Bigner; Michael R Zalutsky
Vascular targeted endoradiotherapy of tumors using alpha-particle-emitting compounds: theoretical analysis.
International journal of radiation oncology, biology, physics 2002;54(4):1259-75.
2002: Amy B Heimberger; Chris A Learn; Gary E Archer; Roger E McLendon; Tracy A Chewning; Frank L Tuck; John B Pracyk; Allan H Friedman; Henry S Friedman; Darell D Bigner; John H Sampson
Brain tumors in mice are susceptible to blockade of epidermal growth factor receptor (EGFR) with the oral, specific, EGFR-tyrosine kinase inhibitor ZD1839 (iressa).
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(11):3496-502.
2002: Henry S Friedman; Stephen T Keir; Anthony E Pegg; Peter J Houghton; O Michael Colvin; Robert C Moschel; Darell D Bigner; M Eileen Dolan
O6-benzylguanine-mediated enhancement of chemotherapy.
Molecular cancer therapeutics 2002;1(11):943-8.
2002: Manny Bacolod; Stewart P Johnson; Francis Ali-Osman; Paul Modrich; Nancy S Bullock; O Michael Colvin; Darell D Bigner; Henry S Friedman
Mechanisms of resistance to 1,3-bis(2-chloroethyl)-1-nitrosourea in human medulloblastoma and rhabdomyosarcoma.
Molecular cancer therapeutics 2002;1(9):727-36.
2002: Ahmed Rasheed; James E Herndon; Timothy T Stenzel; Jacqueline G M Raetz; Jason Kendelhardt; Henry S Friedman; Allan H Friedman; Darell D Bigner; Sandra H Bigner; Roger E McLendon
Molecular markers of prognosis in astrocytic tumors.
Cancer 2002;94(10):2688-97.
2002: Jennifer A Quinn; James Pluda; M Eileen Dolan; Shannon M Delaney; Richard S. Kaplan; Jeremy Rich; Allan H Friedman; David A Reardon; John H Sampson; O Michael Colvin; Michael M Haglund; Anthony E Pegg; Robert C Moschel; Roger E McLendon; James M Provenzale; Sridharan Gururangan; Sandra Tourt-Uhlig; James E Herndon; Darell D Bigner; Henry S Friedman
Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(9):2277-83.
2002: Naji Aldosari; Rodney N Wiltshire; Amalia Dutra; Evelin Schrock; Roger E McLendon; Henry S Friedman; Darell D Bigner; Sandra H Bigner
Comprehensive molecular cytogenetic investigation of chromosomal abnormalities in human medulloblastoma cell lines and xenograft.
Neuro-oncology 2002;4(2):75-85.
2002: David A Reardon; Gamal Akabani; R Edward Coleman; Allan H Friedman; Henry S Friedman; James E Herndon; Ilkcan Cokgor; Roger E McLendon; Charles N Pegram; James M Provenzale; Jennifer A Quinn; Jeremy Rich; Lorna V Regalado; John H Sampson; Timothy D Shafman; Carol J Wikstrand; Terence Z Wong; Xiao-Guang Zhao; Michael R Zalutsky; Darell D Bigner
Phase II trial of murine (131)I-labeled antitenascin monoclonal antibody 81C6 administered into surgically created resection cavities of patients with newly diagnosed malignant gliomas.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(5):1389-97.
2002: Carol J Wikstrand; Vanessa R Cole; Laura E Crotty; John H Sampson; Darell D Bigner
Generation of anti-idiotypic reagents in the EGFRvIII tumor-associated antigen system.
Cancer immunology, immunotherapy : CII 2002;50(12):639-52.
2002: Amy B Heimberger; Gary E Archer; Laura E Crotty; Roger E McLendon; Allan H Friedman; Henry S Friedman; Darell D Bigner; John H Sampson
Dendritic cells pulsed with a tumor-specific peptide induce long-lasting immunity and are effective against murine intracerebral melanoma.
Neurosurgery 2002;50(1):158-64; discussion 164-6.
2002: Ganesan Vaidyanathan; Donna J Affleck; Darell D Bigner; Michael R Zalutsky
Improved xenograft targeting of tumor-specific anti-epidermal growth factor receptor variant III antibody labeled using N-succinimidyl 4-guanidinomethyl-3-iodobenzoate.
Nuclear medicine and biology 2002;29(1):1-11.
2001: Henry S Friedman; Stephen T Keir; Peter J Houghton; AA Lawless; Darell D Bigner; Sandra J Waters
Activity of irofulven (6-hydroxymethylacylfulvene) in the treatment of glioblastoma multiforme-derived xenografts in athymic mice.
Cancer chemotherapy and pharmacology 2001;48(5):413-6.
2001: Michael R Zalutsky; Xiao-Guang Zhao; Kevin L Alston; Darell D Bigner
High-level production of alpha-particle-emitting (211)At and preparation of (211)At-labeled antibodies for clinical use.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2001;42(10):1508-15.
2001: CF Foulon; Philip Welsh; Darell D Bigner; Michael R Zalutsky
Positively charged templates for labeling internalizing antibodies: comparison of N-succinimidyl 5-iodo-3-pyridinecarboxylate and the D-amino acid peptide KRYRR.
Nuclear medicine and biology 2001;28(7):769-77.
2001: Stephen T Keir; FREDERICK HAUSHEER; AA Lawless; Darell D Bigner; Henry S Friedman
Therapeutic activity of 7-[(2-trimethylsilyl)ethyl)]-20 (S)-camptothecin against central nervous system tumor-derived xenografts in athymic mice.
Cancer chemotherapy and pharmacology 2001;48(1):83-7.
2001: Chien-Tsun Kuan; Carol J Wikstrand; Darell D Bigner
EGF mutant receptor vIII as a molecular target in cancer therapy.
Endocrine-related cancer 2001;8(2):83-96.
2001: Ilkcan Cokgor; Gamal Akabani; Henry S Friedman; Allan H Friedman; Michael R Zalutsky; L M Zehngebot; James M Provenzale; CD Guy; Carol J Wikstrand; Darell D Bigner
Long term response in a patient with neoplastic meningitis secondary to melanoma treated with (131)I-radiolabeled antichondroitin proteoglycan sulfate Mel-14 F(ab')(2): a case study.
Cancer 2001;91(9):1809-13.
2001: Jeremy Rich; C Guo; Roger E McLendon; Darell D Bigner; Xiao-Fan Wang; Christopher M Counter
A genetically tractable model of human glioma formation.
Cancer research 2001;61(9):3556-60.
2000: Chien-Tsun Kuan; Carol J Wikstrand; Gary E Archer; R Beers; Ira Pastan; Michael R Zalutsky; Darell D Bigner
Increased binding affinity enhances targeting of glioma xenografts by EGFRvIII-specific scFv.
International journal of cancer. Journal international du cancer 2000;88(6):962-9.
2000: Ilkcan Cokgor; Gamal Akabani; Chien-Tsun Kuan; Henry S Friedman; Allan H Friedman; R Edward Coleman; Roger E McLendon; Sandra H Bigner; Xiao-Guang Zhao; AM Garcia-Turner; Charles N Pegram; Carol J Wikstrand; Timothy D Shafman; James E Herndon; James M Provenzale; Michael R Zalutsky; Darell D Bigner
Phase I trial results of iodine-131-labeled antitenascin monoclonal antibody 81C6 treatment of patients with newly diagnosed malignant gliomas.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(22):3862-72.
2000: Henry S Friedman; James Pluda; Jennifer A Quinn; Reginald Ewesuedo; L Long; Allan H Friedman; Ilkcan Cokgor; O Michael Colvin; Michael M Haglund; DM Ashley; Jeremy Rich; J Sampson; Anthony E Pegg; Robert C Moschel; Roger E McLendon; James M Provenzale; ES Stewart; Sandra Tourt-Uhlig; AM Garcia-Turner; James E Herndon; Darell D Bigner; M Eileen Dolan
Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant glioma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(20):3522-8.
2000: Vikas J Patel; GB Elion; Peter J Houghton; Stephen T Keir; Anthony E Pegg; Stewart P Johnson; M Eileen Dolan; Darell D Bigner; Henry S Friedman
Schedule-dependent activity of temozolomide plus CPT-11 against a human central nervous system tumor-derived xenograft.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(10):4154-7.
2000: Amy B Heimberger; Gary E Archer; Roger E McLendon; C Hulette; Allan H Friedman; Henry S Friedman; Darell D Bigner; John H Sampson
Temozolomide delivered by intracerebral microinfusion is safe and efficacious against malignant gliomas in rats.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(10):4148-53.
2000: CF Foulon; Craig J Reist; Darell D Bigner; Michael R Zalutsky
Radioiodination via D-amino acid peptide enhances cellular retention and tumor xenograft targeting of an internalizing anti-epidermal growth factor receptor variant III monoclonal antibody.
Cancer research 2000;60(16):4453-60.
2000: Roger E McLendon; Carol J Wikstrand; MR Matthews; R Al-Baradei; Sandra H Bigner; Darell D Bigner
Glioma-associated antigen expression in oligodendroglial neoplasms. Tenascin and epidermal growth factor receptor.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2000;48(8):1103-10.
2000: John H Sampson; Laura E Crotty; S Lee; Gary E Archer; DM Ashley; Carol J Wikstrand; Laura P Hale; C Small; Glenn Dranoff; Allan H Friedman; Henry S Friedman; Darell D Bigner
Unarmed, tumor-specific monoclonal antibody effectively treats brain tumors.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(13):7503-8.
2000: Naji Aldosari; B K Ahmed Rasheed; Roger E McLendon; Henry S Friedman; Darell D Bigner; Sandra H Bigner
Characterization of chromosome 17 abnormalities in medulloblastomas.
Acta neuropathologica 2000;99(4):345-51.
2000: Gamal Akabani; Ilkcan Cokgor; R Edward Coleman; D González Trotter; Terence Z Wong; Henry S Friedman; Allan H Friedman; AM Garcia-Turner; James E Herndon; David DeLong; Roger E McLendon; Xiao-Guang Zhao; Charles N Pegram; James M Provenzale; Darell D Bigner; Michael R Zalutsky
Dosimetry and dose-response relationships in newly diagnosed patients with malignant gliomas treated with iodine-131-labeled anti-tenascin monoclonal antibody 81C6 therapy.
International journal of radiation oncology, biology, physics 2000;46(4):947-58.
2000: Amy B Heimberger; Laura E Crotty; Gary E Archer; Roger E McLendon; A Friedman; Glenn Dranoff; Darell D Bigner; John H Sampson
Bone marrow-derived dendritic cells pulsed with tumor homogenate induce immunity against syngeneic intracerebral glioma.
Journal of neuroimmunology 2000;103(1):16-25.
2000: Chien-Tsun Kuan; Carol J Wikstrand; Darell D Bigner
EGFRvIII as a promising target for antibody-based brain tumor therapy.
Brain tumor pathology 2000;17(2):71-8.
2000: Stephen T Keir; M Eileen Dolan; Anthony E Pegg; AA Lawless; Robert C Moschel; Darell D Bigner; Henry S Friedman
O6-benzylguanine-mediated enhancement of nitrosourea activity in Mer- central nervous system tumor xenografts--implications for clinical trials.
Cancer chemotherapy and pharmacology 2000;45(6):437-40.
2000: Robert Craig Castellino; GB Elion; Stephen T Keir; Peter J Houghton; Stewart P Johnson; Darell D Bigner; Henry S Friedman
Schedule-dependent activity of irinotecan plus BCNU against malignant glioma xenografts.
Cancer chemotherapy and pharmacology 2000;45(4):345-9.
1999: Jeremy Rich; Mei Zhang; Michael B Datto; Darell D Bigner; Xiao-Fan Wang
Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines.
The Journal of biological chemistry 1999;274(49):35053-8.
1999: CF Foulon; Darell D Bigner; Michael R Zalutsky
Preparation and characterization of anti-tenascin monoclonal antibody-streptavidin conjugates for pretargeting applications.
Bioconjugate chemistry 1999;10(5):867-76.
1999: Gary E Archer; John H Sampson; I A Lorimer; Roger E McLendon; Chien-Tsun Kuan; Allan H Friedman; Henry S Friedman; Ira Pastan; Darell D Bigner
Regional treatment of epidermal growth factor receptor vIII-expressing neoplastic meningitis with a single-chain immunotoxin, MR-1.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(9):2646-52.
1999: Roger E McLendon; Gary E Archer; Roy H Larsen; Gamal Akabani; Darell D Bigner; Michael R Zalutsky
Radiotoxicity of systemically administered 211At-labeled human/mouse chimeric monoclonal antibody: a long-term survival study with histologic analysis.
International journal of radiation oncology, biology, physics 1999;45(2):491-9.
1999: Sandra H Bigner; MR Matthews; B K Ahmed Rasheed; Rodney N Wiltshire; Henry S Friedman; Allan H Friedman; Timothy T Stenzel; D M Dawes; Roger E McLendon; Darell D Bigner
Molecular genetic aspects of oligodendrogliomas including analysis by comparative genomic hybridization.
The American journal of pathology 1999;155(2):375-86.
1999: Chien-Tsun Kuan; Craig J Reist; CF Foulon; I A Lorimer; Gary E Archer; Charles N Pegram; Ira Pastan; Michael R Zalutsky; Darell D Bigner
125I-labeled anti-epidermal growth factor receptor-vIII single-chain Fv exhibits specific and high-level targeting of glioma xenografts.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(6):1539-49.
1999: Craig J Reist; CF Foulon; Kevin L Alston; Darell D Bigner; Michael R Zalutsky
Astatine-211 labeling of internalizing anti-EGFRvIII monoclonal antibody using N-succinimidyl 5-[211At]astato-3-pyridinecarboxylate.
Nuclear medicine and biology 1999;26(4):405-11.
1999: John H Sampson; Gary E Archer; Alan T Villavicencio; Roger E McLendon; Allan H Friedman; W R Bishop; Darell D Bigner; Henry S Friedman
Treatment of neoplastic meningitis with intrathecal temozolomide.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(5):1183-8.
1999: Henry S Friedman; William P Petros; Allan H Friedman; Larry J Schaaf; T Kerby; J Lawyer; M Parry; Peter J Houghton; S Lovell; Karima Rasheed; T Cloughsey; ES Stewart; O Michael Colvin; James M Provenzale; Roger E McLendon; Darell D Bigner; Ilkcan Cokgor; Michael M Haglund; Jeremy Rich; David Ashley; J Malczyn; Gary L Elfring; Langdon L Miller
Irinotecan therapy in adults with recurrent or progressive malignant glioma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1999;17(5):1516-25.
1999: B K Ahmed Rasheed; Rodney N Wiltshire; Sandra H Bigner; Darell D Bigner
Molecular pathogenesis of malignant gliomas.
Current opinion in oncology 1999;11(3):162-7.
1999: Gamal Akabani; Craig J Reist; Ilkcan Cokgor; Allan H Friedman; Henry S Friedman; R Edward Coleman; Xiao-Guang Zhao; Darell D Bigner; Michael R Zalutsky
Dosimetry of 131I-labeled 81C6 monoclonal antibody administered into surgically created resection cavities in patients with malignant brain tumors.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1999;40(4):631-8.
1999: Carol J Wikstrand; Ilkcan Cokgor; John H Sampson; Darell D Bigner
Monoclonal antibody therapy of human gliomas: current status and future approaches.
Cancer metastasis reviews 1999;18(4):451-64.
1999: Gary E Archer; John H Sampson; Roger E McLendon; Allan H Friedman; O Michael Colvin; M Rose; Howard Sands; W McCullough; Herbert E Fuchs; Darell D Bigner; Henry S Friedman
Intrathecal busulfan treatment of human neoplastic meningitis in athymic nude rats.
Journal of neuro-oncology 1999;44(3):233-41.
1999: Henry S Friedman; Anthony E Pegg; Stewart P Johnson; Natalia A Loktionova; M Eileen Dolan; Paul Modrich; Robert C Moschel; Robert F Struck; T P Brent; Susan M Ludeman; Nancy S Bullock; C Kilborn; Stephen T Keir; Q Dong; Darell D Bigner; O Michael Colvin
Modulation of cyclophosphamide activity by O6-alkylguanine-DNA alkyltransferase.
Cancer chemotherapy and pharmacology 1999;43(1):80-5.
1999: Q Dong; Stewart P Johnson; O Michael Colvin; Nancy S Bullock; C Kilborn; G Runyon; D M Sullivan; J Easton; Darell D Bigner; Rita Nahta; J Marks; Paul Modrich; Henry S Friedman
Multiple DNA repair mechanisms and alkylator resistance in the human medulloblastoma cell line D-283 Med (4-HCR).
Cancer chemotherapy and pharmacology 1999;43(1):73-9.
1998: Henry S Friedman; Roger E McLendon; T Kerby; M Dugan; Sandra H Bigner; A J Henry; DM Ashley; J Krischer; S Lovell; Karima Rasheed; F Marchev; A J Seman; Ilkcan Cokgor; Jeremy Rich; E Stewart; O Michael Colvin; James M Provenzale; Darell D Bigner; Michael M Haglund; Allan H Friedman; Paul Modrich
DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(12):3851-7.
1998: Henry S Friedman; Demetrius M Kokkinakis; James Pluda; Allan H Friedman; Ilkcan Cokgor; Michael M Haglund; DM Ashley; Jeremy Rich; M Eileen Dolan; Anthony E Pegg; Robert C Moschel; Roger E McLendon; T Kerby; James E Herndon; Darell D Bigner; S Clifford Schold
Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(11):3570-5.
1998: Craig J Reist; Darell D Bigner; Michael R Zalutsky
Human IgG2 constant region enhances in vivo stability of anti-tenascin antibody 81C6 compared with its murine parent.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(10):2495-502.
1998: DM Ashley; John H Sampson; Gary E Archer; Laura P Hale; Darell D Bigner
Local production of TGF beta1 inhibits cerebral edema, enhances TNF-alpha induced apoptosis and improves survival in a murine glioma model.
Journal of neuroimmunology 1998;86(1):46-52.
1998: S E Lee; Stewart P Johnson; Laura P Hale; J Li; Nancy S Bullock; Herbert Fuchs; A Friedman; Roger E McLendon; Darell D Bigner; Paul Modrich; Henry S Friedman
Analysis of DNA mismatch repair proteins in human medulloblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(6):1415-9.
1998: Darell D Bigner; M T Brown; Allan H Friedman; R Edward Coleman; Gamal Akabani; Henry S Friedman; W L Thorstad; Roger E McLendon; Sandra H Bigner; Xiao-Guang Zhao; Charles N Pegram; Carol J Wikstrand; James E Herndon; N A Vick; Nina Paleologos; Ilkcan Cokgor; James M Provenzale; Michael R Zalutsky
Iodine-131-labeled antitenascin monoclonal antibody 81C6 treatment of patients with recurrent malignant gliomas: phase I trial results.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(6):2202-12.
1998: Roger E McLendon; L Cleveland; Charles N Pegram; Sandra H Bigner; Darell D Bigner; Henry S Friedman
Immunohistochemical detection of the DNA repair enzyme O6-methylguanine-DNA methyltransferase in formalin-fixed, paraffin-embedded astrocytomas.
Laboratory investigation; a journal of technical methods and pathology 1998;78(5):643-4.
1998: Carol J Wikstrand; Craig J Reist; Gary E Archer; Michael R Zalutsky; Darell D Bigner
The class III variant of the epidermal growth factor receptor (EGFRvIII): characterization and utilization as an immunotherapeutic target.
Journal of neurovirology 1998;4(2):148-58.
1998: DM Ashley; Fengming P Kong; Darell D Bigner; Laura P Hale
Endogenous expression of transforming growth factor beta1 inhibits growth and tumorigenicity and enhances Fas-mediated apoptosis in a murine high-grade glioma model.
Cancer research 1998;58(2):302-9.
1998: M L Hanley; GB Elion; O Michael Colvin; Paul Modrich; Stephen T Keir; David J Adams; Darell D Bigner; Henry S Friedman
Therapeutic efficacy of vinorelbine against pediatric and adult central nervous system tumors.
Cancer chemotherapy and pharmacology 1998;42(6):479-82.
1998: C A Coggins; GB Elion; Peter J Houghton; CB Hare; Stephen T Keir; O Michael Colvin; Darell D Bigner; Henry S Friedman
Enhancement of irinotecan (CPT-11) activity against central nervous system tumor xenografts by alkylating agents.
Cancer chemotherapy and pharmacology 1998;41(6):485-90.
1997: DM Ashley; Surinder Batra; Darell D Bigner
Monoclonal antibodies to growth factors and growth factor receptors: their diagnostic and therapeutic potential in brain tumors.
Journal of neuro-oncology 1997;35(3):259-73.
1997: John H Sampson; DM Ashley; Gary E Archer; Herbert E Fuchs; Glenn Dranoff; Laura P Hale; Darell D Bigner
Characterization of a spontaneous murine astrocytoma and abrogation of its tumorigenicity by cytokine secretion.
Neurosurgery 1997;41(6):1365-72; discussion 1372-3.
1997: DM Ashley; Brenda Faiola; Smita Nair; Laura P Hale; Darell D Bigner; Eli Gilboa
Bone marrow-generated dendritic cells pulsed with tumor extracts or tumor RNA induce antitumor immunity against central nervous system tumors.
The Journal of experimental medicine 1997;186(7):1177-82.
1997: Craig J Reist; Surinder Batra; Charles N Pegram; Darell D Bigner; Michael R Zalutsky
In vitro and in vivo behavior of radiolabeled chimeric anti-EGFRvIII monoclonal antibody: comparison with its murine parent.
Nuclear medicine and biology 1997;24(7):639-47.
1997: B K Ahmed Rasheed; Timothy T Stenzel; Roger E McLendon; R Parsons; Allan H Friedman; Henry S Friedman; Darell D Bigner; Sandra H Bigner
PTEN gene mutations are seen in high-grade but not in low-grade gliomas.
Cancer research 1997;57(19):4187-90.
1997: Carol J Wikstrand; Roger E McLendon; Allan H Friedman; Darell D Bigner
Cell surface localization and density of the tumor-associated variant of the epidermal growth factor receptor, EGFRvIII.
Cancer research 1997;57(18):4130-40.
1997: DM Ashley; John H Sampson; Gary E Archer; Surinder Batra; Darell D Bigner; Laura P Hale
A genetically modified allogeneic cellular vaccine generates MHC class I-restricted cytotoxic responses against tumor-associated antigens and protects against CNS tumors in vivo.
Journal of neuroimmunology 1997;78(1-2):34-46.
1997: Henry S Friedman; Stewart P Johnson; Q Dong; S Clifford Schold; B K Ahmed Rasheed; Sandra H Bigner; Francis Ali-Osman; E Dolan; O Michael Colvin; P Houghton; G Germain; JT Drummond; Stephen T Keir; SL Marcelli; Darell D Bigner; Paul Modrich
Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multiforme xenograft.
Cancer research 1997;57(14):2933-6.
1997: Gary E Archer; John H Sampson; Darell D Bigner
Viruses and oncogenes in brain tumors.
Journal of neurovirology 1997;3 Suppl 1():S76-7.
1997: Craig J Reist; Gary E Archer; Carol J Wikstrand; Darell D Bigner; Michael R Zalutsky
Improved targeting of an anti-epidermal growth factor receptor variant III monoclonal antibody in tumor xenografts after labeling using N-succinimidyl 5-iodo-3-pyridinecarboxylate.
Cancer research 1997;57(8):1510-5.
1997: Michael R Zalutsky; M G Stabin; Roy H Larsen; Darell D Bigner
Tissue distribution and radiation dosimetry of astatine-211-labeled chimeric 81C6, an alpha-particle-emitting immunoconjugate.
Nuclear medicine and biology 1997;24(3):255-61.
1997: Marlene L Hauck; Mark Dewhirst; Darell D Bigner; Michael R Zalutsky
Local hyperthermia improves uptake of a chimeric monoclonal antibody in a subcutaneous xenograft model.
Clinical cancer research : an official journal of the American Association for Cancer Research 1997;3(1):63-70.
1997: CB Hare; GB Elion; O Michael Colvin; Francis Ali-Osman; O W Griffith; William P Petros; Stephen T Keir; SL Marcelli; Darell D Bigner; Henry S Friedman
Characterization of the mechanisms of busulfan resistance in a human glioblastoma multiforme xenograft.
Cancer chemotherapy and pharmacology 1997;40(5):409-14.
1997: CB Hare; GB Elion; Peter J Houghton; J A Houghton; Stephen T Keir; SL Marcelli; Darell D Bigner; Henry S Friedman
Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10-(4-[1-piperidino]-1-piperidino)-carbonyloxy-camptothecin against pediatric and adult central nervous system tumor xenografts.
Cancer chemotherapy and pharmacology 1997;39(3):187-91.
1997: K Moynihan; GB Elion; Charles N Pegram; Craig J Reist; D Wellner; Darell D Bigner; O W Griffith; Henry S Friedman
L-amino acid oxidase (LOX) modulation of melphalan activity against intracranial glioma.
Cancer chemotherapy and pharmacology 1997;39(3):179-86.
1996: I A Lorimer; A Keppler-Hafkemeyer; Richard Beers; Charles N Pegram; Darell D Bigner; Ira Pastan
Recombinant immunotoxins specific for a mutant epidermal growth factor receptor: targeting with a single chain antibody variable domain isolated by phage display.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(25):14815-20.
1996: Craig J Reist; Pradeep K Garg; Kevin L Alston; Darell D Bigner; Michael R Zalutsky
Radioiodination of internalizing monoclonal antibodies using N-succinimidyl 5-iodo-3-pyridinecarboxylate.
Cancer research 1996;56(21):4970-7.
1996: John H Sampson; Gary E Archer; DM Ashley; Herbert E Fuchs; Laura P Hale; Glenn Dranoff; Darell D Bigner
Subcutaneous vaccination with irradiated, cytokine-producing tumor cells stimulates CD8+ cell-mediated immunity against tumors located in the "immunologically privileged" central nervous system.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(19):10399-404.
1996: G McCowage; R Tien; Roger E McLendon; G Felsberg; Herbert Fuchs; M L Graham; Joanne Kurtzberg; Albert Moghrabi; L Ferrell; T Kerby; M Duncan-Brown; E Stewart; Patricia L Robertson; O Michael Colvin; B Golembe; Darell D Bigner; Henry S Friedman
Successful treatment of childhood pilocytic astrocytomas metastatic to the leptomeninges with high-dose cyclophosphamide.
Medical and pediatric oncology 1996;27(1):32-9.
1996: M T Brown; R Edward Coleman; Allan H Friedman; Henry S Friedman; Roger E McLendon; R Reiman; G J Felsberg; RD Tien; Sandra H Bigner; Michael R Zalutsky; Xiao-Guang Zhao; Carol J Wikstrand; Charles N Pegram; J E Herndon; N A Vick; Nina Paleologos; R K Fredericks; S Clifford Schold; Darell D Bigner
Intrathecal 131I-labeled antitenascin monoclonal antibody 81C6 treatment of patients with leptomeningeal neoplasms or primary brain tumor resection cavities with subarachnoid communication: phase I trial results.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(6):963-72.
1996: Pam Fredman; Carol J Wikstrand; Jan-Eric Månsson; G Reifenberger; Sandra H Bigner; A Rasheed; Lars Svennerholm; Darell D Bigner
In vivo growth conditions suppress the expression of ganglioside GM2 and favour that of lacto series gangliosides in the human glioma D-54MG cell line.
Glycoconjugate journal 1996;13(3):391-9.
1996: DM Ashley; DC Longee; R Tien; Herbert Fuchs; M L Graham; Joanne Kurtzberg; J Casey; J Olson; L Meier; L Ferrell; T Kerby; M Duncan-Brown; E Stewart; O Michael Colvin; J M Pipas; G McCowage; Roger E McLendon; Darell D Bigner; Henry S Friedman
Treatment of patients with pineoblastoma with high dose cyclophosphamide.
Medical and pediatric oncology 1996;26(6):387-92.
1996: Michael R Zalutsky; Gary E Archer; Pradeep K Garg; Surinder Batra; Darell D Bigner
Chimeric anti-tenascin antibody 81C6: increased tumor localization compared with its murine parent.
Nuclear medicine and biology 1996;23(4):449-58.
1996: Roger E McLendon; K M Fung; R C Bentley; B K Ahmed Rasheed; John Q Trojanowski; Sandra H Bigner; Darell D Bigner; Henry S Friedman
Production and characterization of two ependymoma xenografts.
Journal of neuropathology and experimental neurology 1996;55(5):540-8.
1996: Roger E McLendon; Gary E Archer; Pradeep K Garg; Darell D Bigner; Michael R Zalutsky
Radiotoxicity of systematically administered [211At]astatide in B6C3F1 and BALB/c (nu/nu) mice: a long-term survival study with histologic analysis.
International journal of radiation oncology, biology, physics 1996;35(1):69-80.
1996: Michael R Zalutsky; J M Schuster; Pradeep K Garg; Gary E Archer; Mark Dewhirst; Darell D Bigner
Two approaches for enhancing radioimmunotherapy: alpha emitters and hyperthermia.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 1996;141():101-22.
1996: Michael R Zalutsky; Darell D Bigner
Radioimmunotherapy with alpha-particle emitting radioimmunoconjugates.
Acta oncologica (Stockholm, Sweden) 1996;35(3):373-9.
1996: K Moynihan; GB Elion; Francis Ali-Osman; S Marcelli; Stephen T Keir; Darell D Bigner; Henry S Friedman
Enhancement of melphalan activity by inhibition of DNA polymerase-alpha and DNA polymerase-beta.
Cancer chemotherapy and pharmacology 1996;38(4):349-54.
1996: Q Dong; Nancy S Bullock; Francis Ali-Osman; O Michael Colvin; Darell D Bigner; Henry S Friedman
Repair analysis of 4-hydroperoxycyclophosphamide-induced DNA interstrand crosslinking in the c-myc gene in 4-hydroperoxycyclophosphamide-sensitive and -resistant medulloblastoma cell lines.
Cancer chemotherapy and pharmacology 1996;37(3):242-46.
1995: Q Dong; Daniel Barsky; Michael E Colvin; C F Melius; Susan M Ludeman; J F Moravek; O Michael Colvin; Darell D Bigner; Paul Modrich; Henry S Friedman
A structural basis for a phosphoramide mustard-induced DNA interstrand cross-link at 5'-d(GAC).
Proceedings of the National Academy of Sciences of the United States of America 1995;92(26):12170-4.
1995: Darell D Bigner; Gary E Archer; Roger E McLendon; Henry S Friedman; Herbert E Fuchs; L H Pai; J E Herndon; Ira Pastan
Efficacy of compartmental administration of immunotoxin LMB-1 (B3-LysPE38) in a rat model of carcinomatous meningitis.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(12):1545-55.
1995: S N Kurpad; Xiao-Guang Zhao; Carol J Wikstrand; Surinder Batra; Roger E McLendon; Darell D Bigner
Tumor antigens in astrocytic gliomas.
Glia 1995;15(3):244-56.
1995: Surinder Batra; S Castelino-Prabhu; C J Wikstrand; X Zhu; P A Humphrey; Henry S Friedman; Darell D Bigner
Epidermal growth factor ligand-independent, unregulated, cell-transforming potential of a naturally occurring human mutant EGFRvIII gene.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(10):1251-9.
1995: Craig J Reist; Gary E Archer; S N Kurpad; Carol J Wikstrand; Ganesan Vaidyanathan; M C Willingham; Moscatello David; Albert J Wong; Darell D Bigner; Michael R Zalutsky
Tumor-specific anti-epidermal growth factor receptor variant III monoclonal antibodies: use of the tyramine-cellobiose radioiodination method enhances cellular retention and uptake in tumor xenografts.
Cancer research 1995;55(19):4375-82.
1995: S N Kurpad; Henry S Friedman; Gary E Archer; Roger E McLendon; W M Petros; Herbert E Fuchs; A Guaspari; Darell D Bigner
Intraarterial administration of melphalan for treatment of intracranial human glioma xenografts in athymic rats.
Cancer research 1995;55(17):3803-9.
1995: I A Lorimer; C J Wikstrand; Surinder Batra; Darell D Bigner; Ira Pastan
Immunotoxins that target an oncogenic mutant epidermal growth factor receptor expressed in human tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 1995;1(8):859-64.
1995: Henry S Friedman; M Eileen Dolan; Anthony E Pegg; S Marcelli; Stephen T Keir; J J Catino; Darell D Bigner; S Clifford Schold
Activity of temozolomide in the treatment of central nervous system tumor xenografts.
Cancer research 1995;55(13):2853-7.
1995: B K Ahmed Rasheed; Roger E McLendon; Henry S Friedman; Allan H Friedman; Herbert E Fuchs; Darell D Bigner; Sandra H Bigner
Chromosome 10 deletion mapping in human gliomas: a common deletion region in 10q25.
Oncogene 1995;10(11):2243-6.
1995: SM Castellino; Henry S Friedman; GB Elion; E T Ong; S L Marcelli; R Page; Darell D Bigner; Mark Dewhirst
Flunarizine enhancement of melphalan activity against drug-sensitive/resistant rhabdomyosarcoma.
British journal of cancer 1995;71(6):1181-7.
1995: R M Foltz; Roger E McLendon; Henry S Friedman; R K Dodge; Darell D Bigner; Mark Dewhirst
A pial window model for the intracranial study of human glioma microvascular function.
Neurosurgery 1995;36(5):976-84; discussion 984-5.
1995: Ira Pastan; Gary E Archer; Roger E McLendon; H S Friedman; Herbert E Fuchs; Qing-Cheng Wang; L H Pai; J Herndon; Darell D Bigner
Intrathecal administration of single-chain immunotoxin, LMB-7 [B3(Fv)-PE38], produces cures of carcinomatous meningitis in a rat model.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(7):2765-9.
1995: Surinder Batra; Roger E McLendon; Ja Seok Koo; S Castelino-Prabhu; Herbert E Fuchs; J P Krischer; Henry S Friedman; Darell D Bigner; Sandra H Bigner
Prognostic implications of chromosome 17p deletions in human medulloblastomas.
Journal of neuro-oncology 1995;24(1):39-45.
1995: Darell D Bigner; M Brown; R Edward Coleman; Allan H Friedman; Henry S Friedman; Roger E McLendon; Sandra H Bigner; Xiao-Guang Zhao; Carol J Wikstrand; Charles N Pegram
Phase I studies of treatment of malignant gliomas and neoplastic meningitis with 131I-radiolabeled monoclonal antibodies anti-tenascin 81C6 and anti-chondroitin proteoglycan sulfate Me1-14 F (ab')2--a preliminary report.
Journal of neuro-oncology 1995;24(1):109-22.
1995: Henry S Friedman; Sandra H Bigner; Darell D Bigner
Cyclophosphamide therapy of medulloblastoma: from the laboratory to the clinic and back again (and again and again).
Journal of neuro-oncology 1995;24(1):103-8.
1995: J M Schuster; Michael R Zalutsky; M A Noska; R Dodge; Henry S Friedman; Darell D Bigner; Mark Dewhirst
Hyperthermic modulation of radiolabelled antibody uptake in a human glioma xenograft and normal tissues.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 1995;11(1):59-72.
1994: Surinder Batra; B K Ahmed Rasheed; Sandra H Bigner; Darell D Bigner
Oncogenes and anti-oncogenes in human central nervous system tumors.
Laboratory investigation; a journal of technical methods and pathology 1994;71(5):621-37.
1994: Michael R Zalutsky; Roger E McLendon; Pradeep K Garg; Gary E Archer; J M Schuster; Darell D Bigner
Radioimmunotherapy of neoplastic meningitis in rats using an alpha-particle-emitting immunoconjugate.
Cancer research 1994;54(17):4719-25.
1994: Henry S Friedman; Gary E Archer; Roger E McLendon; J M Schuster; O Michael Colvin; A Guaspari; R Blum; P A Savina; Herbert E Fuchs; Darell D Bigner
Intrathecal melphalan therapy of human neoplastic meningitis in athymic nude rats.
Cancer research 1994;54(17):4710-4.
1994: Henry S Friedman; M Eileen Dolan; Scott H Kaufmann; O Michael Colvin; O W Griffith; Robert C Moschel; S Clifford Schold; Darell D Bigner; Francis Ali-Osman
Elevated DNA polymerase alpha, DNA polymerase beta, and DNA topoisomerase II in a melphalan-resistant rhabdomyosarcoma xenograft that is cross-resistant to nitrosoureas and topotecan.
Cancer research 1994;54(13):3487-93.
1994: Roger E McLendon; Darell D Bigner
Immunohistochemistry of the glial fibrillary acidic protein: basic and applied considerations.
Brain pathology (Zurich, Switzerland) 1994;4(3):221-8.
1994: X He; Gary E Archer; Carol J Wikstrand; S L Morrison; Michael R Zalutsky; Darell D Bigner; Surinder Batra
Generation and characterization of a mouse/human chimeric antibody directed against extracellular matrix protein tenascin.
Journal of neuroimmunology 1994;52(2):127-37.
1994: S N Kurpad; Carol J Wikstrand; Darell D Bigner
Immunobiology of malignant astrocytomas.
Seminars in oncology 1994;21(2):149-61.
1994: Surinder Batra; M L Niswonger; Carol J Wikstrand; Charles N Pegram; Michael R Zalutsky; S L Morrison; Darell D Bigner
Mouse/human chimeric Me1-14 antibody: genomic cloning of the variable region genes, linkage to human constant region genes, expression, and characterization.
Hybridoma 1994;13(2):87-97.
1994: B K Ahmed Rasheed; Roger E McLendon; J E Herndon; Henry S Friedman; Allan H Friedman; Darell D Bigner; Sandra H Bigner
Alterations of the TP53 gene in human gliomas.
Cancer research 1994;54(5):1324-30.
1994: Carol J Wikstrand; Pam Fredman; R R McLendon; Lars Svennerholm; Darell D Bigner
Altered expression of ganglioside phenotypes of human gliomas in vivo and in vitro.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1994;21(2-3):129-38.
1994: Henry S Friedman; Peter J Houghton; S Clifford Schold; Stephen T Keir; Darell D Bigner
Activity of 9-dimethylaminomethyl-10-hydroxycamptothecin against pediatric and adult central nervous system tumor xenografts.
Cancer chemotherapy and pharmacology 1994;34(2):171-4.
1994: R H Aaron; GB Elion; O Michael Colvin; M Graham; Stephen T Keir; Darell D Bigner; Henry S Friedman
Busulfan therapy of central nervous system xenografts in athymic mice.
Cancer chemotherapy and pharmacology 1994;35(2):127-31.
1994: Carol J Wikstrand; Pam Fredman; Lars Svennerholm; Darell D Bigner
Detection of glioma-associated gangliosides GM2, GD2, GD3, 3'-isoLM1 3',6'-isoLD1 in central nervous system tumors in vitro and in vivo using epitope-defined monoclonal antibodies.
Progress in brain research 1994;101():213-23.
1993: S Garg; Pradeep K Garg; Xiao-Guang Zhao; Henry S Friedman; Darell D Bigner; Michael R Zalutsky
Radioiodination of a monoclonal antibody using N-succinimidyl 5-iodo-3-pyridinecarboxylate.
Nuclear medicine and biology 1993;20(7):835-42.
1993: S N Ibrahim; V A Lightner; J B Ventimiglia; G K Ibrahim; P J Walther; Darell D Bigner; P A Humphrey
Tenascin expression in prostatic hyperplasia, intraepithelial neoplasia, and carcinoma.
Human pathology 1993;24(9):982-9.
1993: Carol J Wikstrand; S D Stanley; P A Humphrey; Charles N Pegram; Gary E Archer; S Kurpad; M Shibuya; Darell D Bigner
Investigation of a synthetic peptide as immunogen for a variant epidermal growth factor receptor associated with gliomas.
Journal of neuroimmunology 1993;46(1-2):165-73.
1993: S Clifford Schold; Michael R Zalutsky; R Edward Coleman; M J Glantz; Allan H Friedman; Ronald J Jaszczak; Sandra H Bigner; Darell D Bigner
Distribution and dosimetry of I-123-labeled monoclonal antibody 81C6 in patients with anaplastic glioma.
Investigative radiology 1993;28(6):488-96.
1993: J M Schuster; Henry S Friedman; Gary E Archer; Herbert E Fuchs; Roger E McLendon; O Michael Colvin; Darell D Bigner
Intraarterial therapy of human glioma xenografts in athymic rats using 4-hydroperoxycyclophosphamide.
Cancer research 1993;53(10 Suppl):2338-43.
1993: SM Castellino; GB Elion; O W Griffith; Mark Dewhirst; Joanne Kurtzberg; R C Cattley; P Scott; Darell D Bigner; Henry S Friedman
Development of a model of melphalan-induced gastrointestinal toxicity in mice.
Cancer chemotherapy and pharmacology 1993;31(5):376-80.
1993: S Clifford Schold; J E Herndon; Peter C Burger; Edward C Halperin; N A Vick; J Gregory Cairncross; D R Macdonald; E J Dropcho; R Morawetz; Darell D Bigner
Randomized comparison of diaziquone and carmustine in the treatment of adults with anaplastic glioma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1993;11(1):77-83.
1993: Carol J Wikstrand; DC Longee; Roger E McLendon; G N Fuller; Henry S Friedman; Pam Fredman; Lars Svennerholm; Darell D Bigner
Lactotetraose series ganglioside 3',6'-isoLD1 in tumors of central nervous and other systems in vitro and in vivo.
Cancer research 1993;53(1):120-6.
1993: Thomas P Brent; M A von Wronski; C C Edwards; M Bromley; Geoffrey P Margison; Joseph Rafferty; Charles N Pegram; Darell D Bigner
Identification of nitrosourea-resistant human rhabdomyosarcomas by in situ immunostaining of O6-methylguanine-DNA methyltransferase.
Oncology research 1993;5(2):83-6.
1992: Henry S Friedman; M Eileen Dolan; Robert C Moschel; Anthony E Pegg; G M Felker; Jeremy Rich; Darell D Bigner; S Clifford Schold
Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme.
Journal of the National Cancer Institute 1992;84(24):1926-31.
1992: Darell D Bigner
M. Stephen Mahaley, Jr., M.D., Ph.D., 1932-1992.
Journal of neurosurgery 1992;77(6):829-31.
1992: Carol J Wikstrand; Pam Fredman; Lars Svennerholm; P A Humphrey; Sandra H Bigner; Darell D Bigner
Monoclonal antibodies to malignant human gliomas.
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid 1992;17(2):137-46.
1992: Henry S Friedman; O Michael Colvin; Scott H Kaufmann; Susan M Ludeman; Nancy S Bullock; Darell D Bigner; O W Griffith
Cyclophosphamide resistance in medulloblastoma.
Cancer research 1992;52(19):5373-8.
1992: Pradeep K Garg; S Garg; Darell D Bigner; Michael R Zalutsky
Localization of fluorine-18-labeled Mel-14 monoclonal antibody F(ab')2 fragment in a subcutaneous xenograft model.
Cancer research 1992;52(18):5054-60.
1992: W W Vick; J W Tello; Carol J Wikstrand; X He; DC Longee; Pam Fredman; Lars Svennerholm; Darell D Bigner; W W Johnston; Sandra H Bigner
Application of a panel of antiganglioside monoclonal antibodies to cytologic specimens.
Acta cytologica 1992;36(5):697-705.
1992: R P Moseley; V Papanastassiou; Michael R Zalutsky; R D Ashpole; S Evans; Darell D Bigner; JT Kemshead
Immunoreactivity, pharmacokinetics and bone marrow dosimetry of intrathecal radioimmunoconjugates.
International journal of cancer. Journal international du cancer 1992;52(1):38-43.
1992: Ganesan Vaidyanathan; Darell D Bigner; Michael R Zalutsky
Fluorine-18-labeled monoclonal antibody fragments: a potential approach for combining radioimmunoscintigraphy and positron emission tomography.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 1992;33(8):1535-41.
1992: B K Ahmed Rasheed; G N Fuller; Allan H Friedman; Darell D Bigner; Sandra H Bigner
Loss of heterozygosity for 10q loci in human gliomas.
Genes, chromosomes & cancer 1992;5(1):75-82.
1992: J M Schuster; Darell D Bigner
Immunotherapy and monoclonal antibody therapies.
Current opinion in oncology 1992;4(3):547-52.
1992: Madan M Kwatra; Darell D Bigner; Jonathan A Cohn
The ligand binding domain of the epidermal growth factor receptor is not required for receptor dimerization.
Biochimica et biophysica acta 1992;1134(2):178-81.
1992: Daniel T Laskowitz; GB Elion; Mark Dewhirst; O W Griffith; Robert A Casero; P A Scott; Nancy S Bullock; Darell D Bigner; Henry S Friedman
Effects of glutathione or polyamine depletion on in vivo thermosensitization.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 1992;8(2):199-208.
1992: S Shiota; M A von Wronski; K Tano; Darell D Bigner; Thomas P Brent; Sankar Mitra
Characterization of cDNA encoding mouse DNA repair protein O6-methylguanine-DNA methyltransferase and high-level expression of the wild-type and mutant proteins in Escherichia coli.
Biochemistry 1992;31(7):1897-903.
1992: Daniel T Laskowitz; GB Elion; Mark Dewhirst; O W Griffith; P M Savina; M R Blum; D M Prescott; Darell D Bigner; Henry S Friedman
Hyperthermia-induced enhancement of melphalan activity against a melphalan-resistant human rhabdomyosarcoma xenograft.
Radiation research 1992;129(2):218-23.
1992: Daniel T Laskowitz; GB Elion; Mark Dewhirst; O W Griffith; R C Cattley; Darell D Bigner; Henry S Friedman
Enhancement of melphalan-induced gastrointestinal toxicity in mice treated with regional hyperthermia and BSO-mediated glutathione depletion.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 1992;8(1):111-20.
1992: Edward C Halperin; David M. Brizel; G Honore; M R Sontag; O W Griffith; Darell D Bigner; Henry S Friedman
The radiation dose-response relationship in a human glioma xenograft and an evaluation of the influence of glutathione depletion by buthionine sulfoximine.
International journal of radiation oncology, biology, physics 1992;24(1):103-9.
1992: M A von Wronski; Linda C Harris; K Tano; Sankar Mitra; Darell D Bigner; Thomas P Brent
Cytosine methylation and suppression of O6-methylguanine-DNA methyltransferase expression in human rhabdomyosarcoma cell lines and xenografts.
Oncology research 1992;4(4-5):167-74.
1992: J B Ventimiglia; Carol J Wikstrand; L E Ostrowski; M A Bourdon; V A Lightner; Darell D Bigner
Tenascin expression in human glioma cell lines and normal tissues.
Journal of neuroimmunology 1992;36(1):41-55.
1991: Carol J Wikstrand; X M He; G N Fuller; Sandra H Bigner; Pam Fredman; Lars Svennerholm; Darell D Bigner
Occurrence of lacto series gangliosides 3'-isoLM1 and 3',6'-isoLD1 in human gliomas in vitro and in vivo.
Journal of neuropathology and experimental neurology 1991;50(6):756-69.
1991: K Tano; S Shiota; Joanna S Remack; Thomas P Brent; Darell D Bigner; Sankar Mitra
The origin of O6-methylguanine-DNA methyltransferase in Chinese hamster ovary cells transfected with human DNA.
Mutation research 1991;255(2):175-82.
1991: L E Ostrowski; M A von Wronski; Sandra H Bigner; A Rasheed; S Clifford Schold; Thomas P Brent; Sankar Mitra; Darell D Bigner
Expression of O6-methylguanine-DNA methyltransferase in malignant human glioma cell lines.
Carcinogenesis 1991;12(9):1739-44.
1991: Rolf Bjerkvig; O Engebraaten; Ole Didrik Laerum; Pam Fredman; Lars Svennerholm; F D Vrionis; Carol J Wikstrand; Darell D Bigner
Anti-GM2 monoclonal antibodies induce necrosis in GM2-rich cultures of a human glioma cell line.
Cancer research 1991;51(17):4643-8.
1991: J M Schuster; Pradeep K Garg; Darell D Bigner; Michael R Zalutsky
Improved therapeutic efficacy of a monoclonal antibody radioiodinated using N-succinimidyl-3-(tri-n-butylstannyl)benzoate.
Cancer research 1991;51(16):4164-9.
1991: P A Humphrey; Lisa Gangarosa; Albert J Wong; Gary E Archer; Morten Lund-Johansen; Rolf Bjerkvig; Ole Didrik Laerum; Henry S Friedman; Darell D Bigner
Deletion-mutant epidermal growth factor receptor in human gliomas: effects of type II mutation on receptor function.
Biochemical and biophysical research communications 1991;178(3):1413-20.
1991: Henry S Friedman; W Jerry Oakes; Sandra H Bigner; Carol J Wikstrand; Darell D Bigner
Medulloblastoma: tumor biological and clinical perspectives.
Journal of neuro-oncology 1991;11(1):1-15.
1991: E R Lilley; GB Elion; Mark Dewhirst; S Clifford Schold; M R Blum; P M Savina; Daniel T Laskowitz; Darell D Bigner; Henry S Friedman
Therapeutic analysis of melphalan-resistant human rhabdomyosarcoma xenograft TE-671 MR.
Cancer research 1991;51(15):3906-9.
1991: L E Ostrowski; Charles N Pegram; M A Von Wronski; P A Humphrey; X M He; S Shiota; Sankar Mitra; Thomas P Brent; Darell D Bigner
Production and characterization of antipeptide antibodies against human O6-methylguanine-DNA methyltransferase.
Cancer research 1991;51(13):3339-44.
1991: X M He; Carol J Wikstrand; Henry S Friedman; Sandra H Bigner; S Pleasure; John Q Trojanowski; Darell D Bigner
Differentiation characteristics of newly established medulloblastoma cell lines (D384 Med, D425 Med, and D458 Med) and their transplantable xenografts.
Laboratory investigation; a journal of technical methods and pathology 1991;64(6):833-43.
1991: J M Schuster; Henry S Friedman; Darell D Bigner
Therapeutic analysis of in vitro and in vivo brain tumor models.
Neurologic clinics 1991;9(2):375-82.
1991: Johan Gottfries; Alan K Percy; Jan-Eric Månsson; Pam Fredman; Carol J Wikstrand; H S Friedman; Darell D Bigner; Lars Svennerholm
Glycolipids and glycosyltransferases in permanent cell lines established from human medulloblastomas.
Biochimica et biophysica acta 1991;1081(3):253-61.
1991: M A von Wronski; S Shiota; K Tano; Sankar Mitra; Darell D Bigner; Thomas P Brent
Structural and immunological comparison of indigenous human O6-methylguanine-DNA methyltransferase with that encoded by a cloned cDNA.
The Journal of biological chemistry 1991;266(2):1064-70.
1991: A M Wang; GB Elion; Henry S Friedman; W J Bodell; Darell D Bigner; S Clifford Schold
Positive therapeutic interaction between thiopurines and alkylating drugs in human glioma xenografts.
Cancer chemotherapy and pharmacology 1991;27(4):278-84.
1991: Carol J Wikstrand; Henry S Friedman; Darell D Bigner
Medulloblastoma cell-substrate interaction in vitro.
Invasion & metastasis 1991;11(6):310-24.
1991: DC Longee; Carol J Wikstrand; Jan-Eric Månsson; X He; G N Fuller; Sandra H Bigner; Pam Fredman; Lars Svennerholm; Darell D Bigner
Disialoganglioside GD2 in human neuroectodermal tumor cell lines and gliomas.
Acta neuropathologica 1991;82(1):45-54.
1990: Sandra H Bigner; P A Humphrey; Albert J Wong; Bert Vogelstein; J Mark; Henry S Friedman; Darell D Bigner
Characterization of the epidermal growth factor receptor in human glioma cell lines and xenografts.
Cancer research 1990;50(24):8017-22.
1990: Johan Gottfries; Pam Fredman; Jan-Eric Månsson; V P Collins; Hans von Holst; Dawna Duncan Armstrong; Alan K Percy; Carol J Wikstrand; Darell D Bigner; Lars Svennerholm
Determination of gangliosides in six human primary medulloblastomas.
Journal of neurochemistry 1990;55(4):1322-6.
1990: Morten Lund-Johansen; Rolf Bjerkvig; P A Humphrey; S H Bigner; Darell D Bigner; Ole Didrik Laerum
Effect of epidermal growth factor on glioma cell growth, migration, and invasion in vitro.
Cancer research 1990;50(18):6039-44.
1990: Pam Fredman; Jan-Eric Månsson; Sandra H Bigner; Carol J Wikstrand; Darell D Bigner; Lars Svennerholm
Gangliosides in the human glioma cell line U-118 MG grown in culture or as xenografts in nude rats.
Biochimica et biophysica acta 1990;1045(3):239-44.
1990: Sandra H Bigner; J Mark; Darell D Bigner
Cytogenetics of human brain tumors.
Cancer genetics and cytogenetics 1990;47(2):141-54.
1990: Michael R Zalutsky; R P Moseley; J C Benjamin; E V Colapinto; G N Fuller; H P Coakham; Darell D Bigner
Monoclonal antibody and F(ab')2 fragment delivery to tumor in patients with glioma: comparison of intracarotid and intravenous administration.
Cancer research 1990;50(13):4105-10.
1990: P A Humphrey; Albert J Wong; Bert Vogelstein; Michael R Zalutsky; G N Fuller; Gary E Archer; Henry S Friedman; Madan M Kwatra; S H Bigner; Darell D Bigner
Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(11):4207-11.
1990: W Jerry Oakes; Henry S Friedman; Sandra H Bigner; Nancy S Bullock; Darell D Bigner
Successful laboratory growth and analysis of CUSA-obtained medulloblastoma samples. Technical note.
Journal of neurosurgery 1990;72(5):821-3.
1990: S A Shoup; W W Johnston; H F Siegler; J W Tello; J Schlom; Darell D Bigner; Sandra H Bigner
A panel of antibodies useful in the cytologic diagnosis of metastatic melanoma.
Acta cytologica 1990;34(3):385-92.
1990: G Karlsson; Jan-Eric Månsson; Carol J Wikstrand; Darell D Bigner; Lars Svennerholm
Characterization of the binding epitope of the monoclonal antibody DMAb-1 to ganglioside GM2.
Biochimica et biophysica acta 1990;1043(3):267-72.
1990: Sandra H Bigner; Henry S Friedman; Bert Vogelstein; W Jerry Oakes; Darell D Bigner
Amplification of the c-myc gene in human medulloblastoma cell lines and xenografts.
Cancer research 1990;50(8):2347-50.
1990: E V Colapinto; Michael R Zalutsky; Gary E Archer; M A Noska; Henry S Friedman; S Carrel; Darell D Bigner
Radioimmunotherapy of intracerebral human glioma xenografts with 131I-labeled F(ab')2 fragments of monoclonal antibody Mel-14.
Cancer research 1990;50(6):1822-7.
1990: D A Cope; Mark Dewhirst; Henry S Friedman; Darell D Bigner; Michael R Zalutsky
Enhanced delivery of a monoclonal antibody F(ab')2 fragment to subcutaneous human glioma xenografts using local hyperthermia.
Cancer research 1990;50(6):1803-9.
1990: Herbert E Fuchs; Gary E Archer; O Michael Colvin; Sandra H Bigner; J M Schuster; G N Fuller; L H Muhlbaier; S Clifford Schold; Henry S Friedman; Darell D Bigner
Activity of intrathecal 4-hydroperoxycyclophosphamide in a nude rat model of human neoplastic meningitis.
Cancer research 1990;50(6):1954-9.
1990: B E Lippitz; Edward C Halperin; O W Griffith; O Michael Colvin; G Honore; C B Ostertag; Darell D Bigner; Henry S Friedman
L-buthionine-sulfoximine-mediated radiosensitization in experimental interstitial radiotherapy of intracerebral D-54 MG glioma xenografts in athymic mice.
Neurosurgery 1990;26(2):255-60.
1990: E R Lilley; M C Rosenberg; GB Elion; O Michael Colvin; Darell D Bigner; Henry S Friedman
Synergistic interactions between cyclophosphamide or melphalan and VP-16 in a human rhabdomyosarcoma xenograft.
Cancer research 1990;50(2):284-7.
1990: Thomas P Brent; M von Wronski; Charles N Pegram; Darell D Bigner
Immunoaffinity purification of human O6-alkylguanine-DNA alkyltransferase using newly developed monoclonal antibodies.
Cancer research 1990;50(1):58-61.
1989: M C Rosenberg; O Michael Colvin; O W Griffith; Sandra H Bigner; GB Elion; J K Horton; E Lilley; Darell D Bigner; Henry S Friedman
Establishment of a melphalan-resistant rhabdomyosarcoma xenograft with cross-resistance to vincristine and enhanced sensitivity following buthionine sulfoximine-mediated glutathione depletion.
Cancer research 1989;49(24 Pt 1):6917-22.
1989: F D Vrionis; Carol J Wikstrand; Pam Fredman; Jan-Eric Månsson; Lars Svennerholm; Darell D Bigner
Five new epitope-defined monoclonal antibodies reactive with GM2 and human glioma and medulloblastoma cell lines.
Cancer research 1989;49(23):6645-51.
1989: Michael R Zalutsky; M A Noska; E V Colapinto; Pradeep K Garg; Darell D Bigner
Enhanced tumor localization and in vivo stability of a monoclonal antibody radioiodinated using N-succinimidyl 3-(tri-n-butylstannyl)benzoate.
Cancer research 1989;49(20):5543-9.
1989: Michael R Zalutsky; Pradeep K Garg; Henry S Friedman; Darell D Bigner
Labeling monoclonal antibodies and F(ab')2 fragments with the alpha-particle-emitting nuclide astatine-211: preservation of immunoreactivity and in vivo localizing capacity.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(18):7149-53.
1989: Pam Fredman; Jan-Eric Månsson; Carol J Wikstrand; F D Vrionis; B M Rynmark; Darell D Bigner; Lars Svennerholm
A new ganglioside of the lactotetraose series, GalNAc-3'-isoLM1, detected in human meconium.
The Journal of biological chemistry 1989;264(21):12122-5.
1989: Sandra H Bigner; S C Schold; Henry S Friedman; J Mark; Darell D Bigner
Chromosomal composition of malignant human gliomas through serial subcutaneous transplantation in athymic mice.
Cancer genetics and cytogenetics 1989;40(1):111-20.
1989: V A Lightner; F Gumkowski; Darell D Bigner; Harold P Erickson
Tenascin/hexabrachion in human skin: biochemical identification and localization by light and electron microscopy.
The Journal of cell biology 1989;108(6):2483-93.
1989: Michael R Zalutsky; R P Moseley; H B Coakham; R Edward Coleman; Darell D Bigner
Pharmacokinetics and tumor localization of 131I-labeled anti-tenascin monoclonal antibody 81C6 in patients with gliomas and other intracranial malignancies.
Cancer research 1989;49(10):2807-13.
1989: Henry S Friedman; O Michael Colvin; O W Griffith; B Lippitz; GB Elion; S Clifford Schold; John Hilton; Darell D Bigner
Increased melphalan activity in intracranial human medulloblastoma and glioma xenografts following buthionine sulfoximine-mediated glutathione depletion.
Journal of the National Cancer Institute 1989;81(7):524-7.
1989: S Clifford Schold; Thomas P Brent; E von Hofe; Henry S Friedman; Sankar Mitra; Darell D Bigner; James A Swenberg; P Kleihues
O6-alkylguanine-DNA alkyltransferase and sensitivity to procarbazine in human brain-tumor xenografts.
Journal of neurosurgery 1989;70(4):573-7.
1989: Johan Gottfries; J E Mansson; Pam Fredman; Carol J Wikstrand; H S Friedman; Darell D Bigner; Lars Svennerholm
Ganglioside mapping of a human medulloblastoma xenograft.
Acta neuropathologica 1989;77(3):283-8.
1989: M A von Wronski; Darell D Bigner; Thomas P Brent
Expression of O6-alkylguanine-DNA alkyltransferase in Mer+ and Mer- human cell extracts probed with specific monoclonal antibodies.
Cancer communications 1989;1(5):323-7.
1989: X He; Carol J Wikstrand; Pam Fredman; Jan-Eric Månsson; Lars Svennerholm; Darell D Bigner
GD3 expression by cultured human tumor cells of neuroectodermal origin.
Acta neuropathologica 1989;79(3):317-25.
1989: Pradeep K Garg; Gary E Archer; Darell D Bigner; Michael R Zalutsky
Synthesis of radioiodinated N-succinimidyl iodobenzoate: optimization for use in antibody labelling.
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes 1989;40(6):485-90.
1989: X M He; Stephen Xavier Skapek; Carol J Wikstrand; Henry S Friedman; John Q Trojanowski; J T Kemshead; H B Coakham; Sandra H Bigner; Darell D Bigner
Phenotypic analysis of four human medulloblastoma cell lines and transplantable xenografts.
Journal of neuropathology and experimental neurology 1989;48(1):48-68.
1988: Stephen Xavier Skapek; O Michael Colvin; O W Griffith; D R Groothuis; E V Colapinto; Y Lee; John Hilton; GB Elion; Darell D Bigner; Henry S Friedman
Buthionine sulfoximine-mediated depletion of glutathione in intracranial human glioma-derived xenografts.
Biochemical pharmacology 1988;37(22):4313-7.
1988: E V Colapinto; P A Humphrey; Michael R Zalutsky; D R Groothuis; Henry S Friedman; N de Tribolet; S Carrel; Darell D Bigner
Comparative localization of murine monoclonal antibody Me1-14 F(ab')2 fragment and whole IgG2a in human glioma xenografts.
Cancer research 1988;48(20):5701-7.
1988: Henry S Friedman; Stephen Xavier Skapek; O Michael Colvin; GB Elion; M R Blum; P M Savina; John Hilton; S Clifford Schold; Joanne Kurtzberg; Darell D Bigner
Melphalan transport, glutathione levels, and glutathione-S-transferase activity in human medulloblastoma.
Cancer research 1988;48(19):5397-402.
1988: Henry S Friedman; O Michael Colvin; Stephen Xavier Skapek; Susan M Ludeman; GB Elion; S Clifford Schold; P F Jacobsen; L H Muhlbaier; Darell D Bigner
Experimental chemotherapy of human medulloblastoma cell lines and transplantable xenografts with bifunctional alkylating agents.
Cancer research 1988;48(15):4189-95.
1988: Stephen Xavier Skapek; O Michael Colvin; O W Griffith; GB Elion; Darell D Bigner; Henry S Friedman
Enhanced melphalan cytotoxicity following buthionine sulfoximine-mediated glutathione depletion in a human medulloblastoma xenograft in athymic mice.
Cancer research 1988;48(10):2764-7.
1988: Y Lee; D E Bullard; P A Humphrey; E V Colapinto; Henry S Friedman; Michael R Zalutsky; R Edward Coleman; Darell D Bigner
Treatment of intracranial human glioma xenografts with 131I-labeled anti-tenascin monoclonal antibody 81C6.
Cancer research 1988;48(10):2904-10.
1988: Sandra H Bigner; Peter C Burger; Albert J Wong; M H Werner; S R Hamilton; L H Muhlbaier; Bert Vogelstein; Darell D Bigner
Gene amplification in malignant human gliomas: clinical and histopathologic aspects.
Journal of neuropathology and experimental neurology 1988;47(3):191-205.
1988: P A Humphrey; Albert J Wong; Bert Vogelstein; Henry S Friedman; M H Werner; Darell D Bigner; Sandra H Bigner
Amplification and expression of the epidermal growth factor receptor gene in human glioma xenografts.
Cancer research 1988;48(8):2231-8.
1988: Y S Lee; D E Bullard; Michael R Zalutsky; R Edward Coleman; Carol J Wikstrand; Henry S Friedman; E V Colapinto; Darell D Bigner
Therapeutic efficacy of antiglioma mesenchymal extracellular matrix 131I-radiolabeled murine monoclonal antibody in a human glioma xenograft model.
Cancer research 1988;48(3):559-66.
1988: Sandra H Bigner; J Mark; Peter C Burger; M S Mahaley; D E Bullard; L H Muhlbaier; Darell D Bigner
Specific chromosomal abnormalities in malignant human gliomas.
Cancer research 1988;48(2):405-11.
1988: Sandra H Bigner; J Mark; Henry S Friedman; J A Biegel; Darell D Bigner
Structural chromosomal abnormalities in human medulloblastoma.
Cancer genetics and cytogenetics 1988;30(1):91-101.
1988: E V Colapinto; Y S Lee; P A Humphrey; Michael R Zalutsky; Henry S Friedman; D E Bullard; Darell D Bigner
The localisation of radiolabelled murine monoclonal antibody 81C6 and its Fab fragment in human glioma xenografts in athymic mice.
British journal of neurosurgery 1988;2(2):179-91.
1988: M H Werner; P A Humphrey; Darell D Bigner; Sandra H Bigner
Growth effects of epidermal growth factor (EGF) and a monoclonal antibody against the EGF receptor on four glioma cell lines.
Acta neuropathologica 1988;77(2):196-201.
1988: F D Vrionis; Carol J Wikstrand; Darell D Bigner
Relevance for neurobiology and neurooncology of antigens of malignant gliomas as defined by monoclonal antibodies.
Annals of the New York Academy of Sciences 1988;540():64-77.
1987: Sandra H Bigner; Albert J Wong; J Mark; L H Muhlbaier; Kenneth W Kinzler; Bert Vogelstein; Darell D Bigner
Relationship between gene amplification and chromosomal deviations in malignant human gliomas.
Cancer genetics and cytogenetics 1987;29(1):165-70.
1987: W W Vick; Carol J Wikstrand; D E Bullard; J Kemshead; H B Coakham; J Schlom; W W Johnston; Darell D Bigner; Sandra H Bigner
The use of a panel of monoclonal antibodies in the evaluation of cytologic specimens from the central nervous system.
Acta cytologica 1987;31(6):815-24.
1983: M A Bourdon; Carol J Wikstrand; H Furthmayr; T J Matthews; Darell D Bigner
Human glioma-mesenchymal extracellular matrix antigen defined by monoclonal antibody.
Cancer research 1983;43(6):2796-805.
1982: Carol J Wikstrand; M A Bourdon; Charles N Pegram; Darell D Bigner
Human fetal brain antigen expression common to tumors of neuroectodermal tissue origin.
Journal of neuroimmunology 1982;3(1):43-62.

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