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Dennis Roop

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Masahito Yasuda; David J Claypool; Erika Guevara; Dennis R Roop; Jiang Chen
Genetic manipulation of keratinocyte stem cells with lentiviral vectors.
Ganna Bilousova; Dennis R Roop
Generation of functional multipotent keratinocytes from mouse induced pluripotent stem cells.
Enrique C Torchia; Lei Zhang; Aaron J Huebner; Subrata Sen; Dennis R Roop
Aurora kinase-A deficiency during skin development impairs cell division and stratification.

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All Publications

2013: Masahito Yasuda; David J Claypool; Erika Guevara; Dennis R Roop; Jiang Chen
Genetic manipulation of keratinocyte stem cells with lentiviral vectors.
Methods in molecular biology (Clifton, N.J.) 2013;989():143-51.
2013: Ganna Bilousova; Dennis R Roop
Generation of functional multipotent keratinocytes from mouse induced pluripotent stem cells.
Methods in molecular biology (Clifton, N.J.) 2013;961():337-50.
2013: Enrique C Torchia; Lei Zhang; Aaron J Huebner; Subrata Sen; Dennis R Roop
Aurora kinase-A deficiency during skin development impairs cell division and stratification.
The Journal of investigative dermatology 2013;133(1):78-86.
2012: Aaron J Huebner; Maria Morasso; Matthias Schäfer; Edward E Schmidt; Sabine Werner; Daisy Dai; Dennis R Roop
Amniotic fluid activates the nrf2/keap1 pathway to repair an epidermal barrier defect in utero.
Developmental cell 2012;23(6):1238-46.
2012: Jiang Chen; Dennis R Roop
Mimicking hair disorders by genetic manipulation of organ-cultured human hair follicles.
The Journal of investigative dermatology 2012;132(10):2312-4.
2012: Yuchun Luo; Martin D McCarter; David A Norris; Steven E Robinson; William A Robinson; Dennis R Roop; David C Thompson; Vasilis Vasiliou; Jianbin Wang; Ying Chen; Katiuscia Dallaglio; Rene Gonzalez; Mayumi Fujita
ALDH1A isozymes are markers of human melanoma stem cells and potential therapeutic targets.
Stem cells (Dayton, Ohio) 2012;30(10):2100-13.
2012: Yuchun Luo; Martin D McCarter; David A Norris; Steven E Robinson; William A Robinson; Dennis R Roop; Richard A Spritz; Moe Takeda; Natalie G Ahn; Katiuscia Dallaglio; Lixia Z Ellis; Rene Gonzalez; Karl D Lewis; Weimin Liu; Mayumi Fujita
Side population cells from human melanoma tumors reveal diverse mechanisms for chemoresistance.
The Journal of investigative dermatology 2012;132(10):2440-50.
2012: E C Torchia; Tamara Terzian; S Acin; Neil Box; C Caulin; B J Kubick; Dennis R Roop
Myc, Aurora Kinase A, and mutant p53(R172H) co-operate in a mouse model of metastatic skin carcinoma.
Oncogene 2012;31(21):2680-90.
2012: Jianning Tao; Dennis R Roop; David R Beier; Wilbur Harrison; Maranke I Koster; Jennifer L Moran; Paul A Overbeek
A spontaneous Fatp4/Scl27a4 splice site mutation in a new murine model for congenital ichthyosis.
PloS one 2012;7(11):e50634.
2011: Sergio Acin; Adel K El-Naggar; Zhongyou Li; Olga Mejia; Dennis R Roop; Carlos Caulin
Gain-of-function mutant p53 but not p53 deletion promotes head and neck cancer progression in response to oncogenic K-ras.
The Journal of pathology 2011;225(4):479-89.
2011: W Bu; G C Chamness; J Chen; C J Creighton; S G Hilsenbeck; J Huang; Shixia Huang; A D Leavitt; G D Morrison; Dennis R Roop; Yi Li
Keratin 6a marks mammary bipotential progenitor cells that can give rise to a unique tumor model resembling human normal-like breast cancer.
Oncogene 2011;30(43):4399-409.
2011: Ganna Bilousova; Jiang Chen; Dennis R Roop
Differentiation of mouse induced pluripotent stem cells into a multipotent keratinocyte lineage.
The Journal of investigative dermatology 2011;131(4):857-64.
2011: Ganna Bilousova; Wallace S Chick; Kelsey S Chow; Stijn De Langhe; Du Hyun Jun; Karen B King; Dwight J Klemm; Dennis R Roop; Enrique C Torchia; Susan M Majka
Osteoblasts derived from induced pluripotent stem cells form calcified structures in scaffolds both in vitro and in vivo.
Stem cells (Dayton, Ohio) 2011;29(2):206-16.
2011: Daisy Dai; Huiping Zhu; Bogdan Wlodarczyk; Lei Zhang; Li Li; Allen G Li; Richard H Finnell; Dennis R Roop; Jiang Chen
Fuz controls the morphogenesis and differentiation of hair follicles through the formation of primary cilia.
The Journal of investigative dermatology 2011;131(2):302-10.
2010: Ganna Bilousova; Dennis R Roop
Altering cell fate: from thymus epithelium to skin stem cells.
Cell stem cell 2010;7(4):419-20.
2010: Neil F Box; Enrique C Torchia; Dennis R Roop
Are stem cell niches shared for skin cancers?
Pigment cell & melanoma research 2010;23(4):517-20.
2010: Kimberly A Honeycutt; RL Waikel; Maranke I Koster; Xiao-Jing Wang; Dennis R Roop
The effect of c-myc on stem cell fate influences skin tumor phenotype.
Molecular carcinogenesis 2010;49(4):315-9.
2010: Fang Li; Qian Huang; Jiang Chen; Yuanlin Peng; Dennis R Roop; Joel S Bedford; Chuan-Yuan Li
Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration.
Science signaling 2010;3(110):ra13.
2009: Soeun Kim; Irene F Choi; Jessica R Quante; Lei Zhang; Dennis R Roop; Maranke I Koster
p63 directly induces expression of Alox12, a regulator of epidermal barrier formation.
Experimental dermatology 2009;18(12):1016-21.
2009: Enrique C Torchia; Yiyun Chen; Hong Sheng; Hiroshi Katayama; James Fitzpatrick; William R Brinkley; Carlos Caulin; Subrata Sen; Dennis R Roop
A genetic variant of Aurora kinase A promotes genomic instability leading to highly malignant skin tumors.
Cancer research 2009;69(18):7207-15.
2009: Maranke I Koster; Barbara Marinari; Aimee S Payne; Piranit N Kantaputra; Antonio Costanzo; Dennis R Roop
DeltaNp63 knockdown mice: A mouse model for AEC syndrome.
American journal of medical genetics. Part A 2009;149A(9):1942-7.
2009: Yosef Refaeli; Anindita Bhoumik; Dennis R Roop; Ze'ev A Ronai
Melanoma-initiating cells: a compass needed.
EMBO reports 2009;10(9):965-72.
2009: Mary Fete; Hans vanBokhoven; Suzanne E Clements; Frank McKeon; Dennis R Roop; Maranke I Koster; Caterina Missero; Laura D Attardi; Vivian A Lombillo; Edward Ratovitski; Meena Julapalli; Derek Ruths; Virginia P Sybert; Elaine C Siegfried; Alanna F Bree
International Research Symposium on Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate (AEC) syndrome.
American journal of medical genetics. Part A 2009;149A(9):1885-93.
2008: Jiang Chen; Dennis R Roop
Genetically engineered mouse models for skin research: taking the next step.
Journal of dermatological science 2008;52(1):1-12.
2008: Sancy A Leachman; Robyn P Hickerson; Peter R Hull; Frances J D Smith; Leonard M Milstone; E Birgitte Lane; Sherri J Bale; Dennis R Roop; W H Irwin McLean; Roger L Kaspar
Therapeutic siRNAs for dominant genetic skin disorders including pachyonychia congenita.
Journal of dermatological science 2008;51(3):151-7.
2008: Maranke I Koster; Dennis R Roop
Sorting out the p63 signaling network.
The Journal of investigative dermatology 2008;128(7):1617-9.
2008: Jillian Guttormsen; Maranke I Koster; John R Stevens; Dennis R Roop; Trevor Williams; Quinton A Winger
Disruption of epidermal specific gene expression and delayed skin development in AP-2 gamma mutant mice.
Developmental biology 2008;317(1):187-95.
2008: Naomi Iwai; Zhijian Zhou; Dennis R Roop; Richard R Behringer
Horizontal basal cells are multipotent progenitors in normal and injured adult olfactory epithelium.
Stem cells (Dayton, Ohio) 2008;26(5):1298-306.
2008: Jiang Chen; Karin Jaeger; Zhining Den; Peter J Koch; John P Sundberg; Dennis R Roop
Mice expressing a mutant Krt75 (K6hf) allele develop hair and nail defects resembling pachyonychia congenita.
The Journal of investigative dermatology 2008;128(2):270-9.
2007: Carlos Caulin; Thao Nguyen; Gene A Lang; Thea M Goepfert; Bill R Brinkley; Wei-Wen Cai; Guillermina Lozano; Dennis R Roop
An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations.
The Journal of clinical investigation 2007;117(7):1893-901.
2007: Viraj R Shah; Maranke I Koster; Dennis R Roop; David M Spencer; Lei Wei; Qi Li; Robert J Schwartz; Jiang Chang
Double-inducible gene activation system for caspase 3 and 9 in epidermis.
Genesis (New York, N.Y. : 2000) 2007;45(4):194-9.
2007: Maranke I Koster; Daisy Dai; Barbara Marinari; Yuji Sano; Antonio Costanzo; Michael Karin; Dennis R Roop
p63 induces key target genes required for epidermal morphogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3255-60.
2007: William Buitrago; Dennis R Roop
Oct-4: the almighty POUripotent regulator?
The Journal of investigative dermatology 2007;127(2):260-2.
2007: Maranke I Koster; Daisy Dai; Dennis R Roop
Conflicting roles for p63 in skin development and carcinogenesis.
Cell cycle (Georgetown, Tex.) 2007;6(3):269-73.
2007: Maranke I Koster; Dennis R Roop
Mechanisms regulating epithelial stratification.
Annual review of cell and developmental biology 2007;23():93-113.
2006: Jiangli Chen; Xing Cheng; Maria Merched-Sauvage; Carlos Caulin; Dennis R Roop; Peter J Koch
An unexpected role for keratin 10 end domains in susceptibility to skin cancer.
Journal of cell science 2006;119(Pt 24):5067-76.
2006: Kimberly A Honeycutt; Zaowen Chen; Maranke I Koster; M Miers; Jed Nuchtern; John Hicks; Dennis R Roop; Jason M Shohet
Deregulated minichromosomal maintenance protein MCM7 contributes to oncogene driven tumorigenesis.
Oncogene 2006;25(29):4027-32.
2006: William M Keyes; Hannes Vogel; Maranke I Koster; Xuecui Guo; Yi Qi; Kristin M Petherbridge; Dennis R Roop; Allan Bradley; Alea A Mills
p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(22):8435-40.
2006: Bach-Cuc Nguyen; Karine Lefort; Anna Mandinova; Dario Antonini; Vikram Devgan; Giusy Della Gatta; Maranke I Koster; Zhuo Zhang; Jian Wang; Alice Tommasi di Vignano; Jan Kitajewski; giovanna chiorino; Dennis R Roop; Caterina Missero; G Paolo Dotto
Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation.
Genes & development 2006;20(8):1028-42.
2006: Maranke I Koster; Shi-Long Lu; Lisa D White; Xiao-Jing Wang; Dennis R Roop
Reactivation of developmentally expressed p63 isoforms predisposes to tumor development and progression.
Cancer research 2006;66(8):3981-6.
2006: Sandra L Grimm; Wen Bu; Mary Ann Longley; Dennis R Roop; Yi Li; Jeffrey M Rosen
Keratin 6 is not essential for mammary gland development.
Breast cancer research : BCR 2006;8(3):R29.
2006: Maranke I Koster; Soeun Kim; Jian Huang; Trevor Williams; Dennis R Roop
TAp63alpha induces AP-2gamma as an early event in epidermal morphogenesis.
Developmental biology 2006;289(1):253-61.
2005: Maranke I Koster; Soeun Kim; Dennis R Roop
P63 deficiency: a failure of lineage commitment or stem cell maintenance?
The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 2005;10(2):118-23.
2005: Jiang Chen; Dennis R Roop
Mouse models in preclinical studies for pachyonychia congenita.
The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 2005;10(1):37-46.
2005: Maranke I Koster; Dennis R Roop
Asymmetric cell division in skin development: a new look at an old observation.
Developmental cell 2005;9(4):444-6.
2005: Cristina Mammucari; Alice Tommasi di Vignano; Andrey A Sharov; Joel Neilson; Matthew C Havrda; Dennis R Roop; Vladimir A Botchkarev; Gerald R Crabtree; G Paolo Dotto
Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control.
Developmental cell 2005;8(5):665-76.
2004: Maranke I Koster; Dennis R Roop
Genetic pathways required for epidermal morphogenesis.
European journal of cell biology 2004;83(11-12):625-9.
2004: Peter J Koch; Dennis R Roop
The role of keratins in epidermal development and homeostasis--going beyond the obvious.
The Journal of investigative dermatology 2004;123(5):x-xi.
2004: Maranke I Koster; Dennis R Roop
p63 and epithelial appendage development.
Differentiation; research in biological diversity 2004;72(8):364-70.
2004: Kimberly A Honeycutt; Maranke I Koster; Dennis R Roop
Genes involved in stem cell fate decisions and commitment to differentiation play a role in skin disease.
The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 2004;9(3):261-8.
2004: Carlos Caulin; Thao Nguyen; Mary A Longley; Zhijian Zhou; Xiao-Jing Wang; Dennis R Roop
Inducible activation of oncogenic K-ras results in tumor formation in the oral cavity.
Cancer research 2004;64(15):5054-8.
2004: Kimberly A Honeycutt; Dennis R Roop
c-Myc and epidermal stem cell fate determination.
The Journal of dermatology 2004;31(5):368-75.
2004: Maranke I Koster; Dennis R Roop
Transgenic mouse models provide new insights into the role of p63 in epidermal development.
Cell cycle (Georgetown, Tex.) 2004;3(4):411-3.
2004: Maranke I Koster; Dennis R Roop
The role of p63 in development and differentiation of the epidermis.
Journal of dermatological science 2004;34(1):3-9.
2004: Maranke I Koster; Soeun Kim; Alea A Mills; Francesco J DeMayo; Dennis R Roop
p63 is the molecular switch for initiation of an epithelial stratification program.
Genes & development 2004;18(2):126-31.
2004: Meral J Arin; Dennis R Roop
Inducible mouse models for inherited skin diseases: implications for skin gene therapy.
Cells, tissues, organs 2004;177(3):160-8.
2003: Nobunao Wakabayashi; Ken Itoh; Junko Wakabayashi; Hozumi Motohashi; Shuhei Noda; Satoru Takahashi; Sumihisa Imakado; Tomoe Kotsuji; Fujio Otsuka; Dennis R Roop; Takanori Harada; James Douglas Engel; Masayuki Yamamoto
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation.
Nature genetics 2003;35(3):238-45.
2002: Maranke I Koster; Kimberly A Huntzinger; Dennis R Roop
Epidermal differentiation: transgenic/knockout mouse models reveal genes involved in stem cell fate decisions and commitment to differentiation.
The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 2002;7(1):41-5.
2002: Delwin J Long; Karim Iskander; Amos Gaikwad; Meral J Arin; Dennis R Roop; Richard Knox; Roberto Barrios; Anil K Jaiswal
Disruption of dihydronicotinamide riboside:quinone oxidoreductase 2 (NQO2) leads to myeloid hyperplasia of bone marrow and decreased sensitivity to menadione toxicity.
The Journal of biological chemistry 2002;277(48):46131-9.
2002: Zhijian Zhou; Dongyan Wang; Xiao-Jing Wang; Dennis R Roop
In utero activation of K5.CrePR1 induces gene deletion.
Genesis (New York, N.Y. : 2000) 2002;32(2):191-2.
2002: Tongyu Cao; Wei He; Dennis R Roop; Xiao-Jing Wang
K14-GLp65 transactivator induces transgene expression in embryonic epidermis.
Genesis (New York, N.Y. : 2000) 2002;32(2):189-90.
2002: Meral J Arin; Dennis R Roop
Use of laser capture microscopy in the analysis of mouse models of human diseases.
Methods in enzymology 2002;356():207-15.
2002: Michal Jarnik; Pierre A de Viragh; Elisabeth Schärer; Donnie Bundman; Martha N Simon; Dennis R Roop; Alasdair C Steven
Quasi-normal cornified cell envelopes in loricrin knockout mice imply the existence of a loricrin backup system.
The Journal of investigative dermatology 2002;118(1):102-9.
2001: Meral J Arin; Dennis R Roop
Disease model: heritable skin blistering.
Trends in molecular medicine 2001;7(9):422-4.
2001: SM Wojcik; Mary A Longley; Dennis R Roop
Discovery of a novel murine keratin 6 (K6) isoform explains the absence of hair and nail defects in mice deficient for K6a and K6b.
The Journal of cell biology 2001;154(3):619-30.
2001: Delwin J Long; RL Waikel; Xiao-Jing Wang; Dennis R Roop; Anil K Jaiswal
NAD(P)H:quinone oxidoreductase 1 deficiency and increased susceptibility to 7,12-dimethylbenz[a]-anthracene-induced carcinogenesis in mouse skin.
Journal of the National Cancer Institute 2001;93(15):1166-70.
2001: RL Waikel; Y Kawachi; P A Waikel; Xiao-Jing Wang; Dennis R Roop
Deregulated expression of c-Myc depletes epidermal stem cells.
Nature genetics 2001;28(2):165-8.
2001: Tongyu Cao; Mary A Longley; Xiao-Jing Wang; Dennis R Roop
An inducible mouse model for epidermolysis bullosa simplex: implications for gene therapy.
The Journal of cell biology 2001;152(3):651-6.
2001: Meral J Arin; Mary A Longley; Xiao-Jing Wang; Dennis R Roop
Focal activation of a mutant allele defines the role of stem cells in mosaic skin disorders.
The Journal of cell biology 2001;152(3):645-9.
2000: Delwin J Long; RL Waikel; Xiao-Jing Wang; Laszlo Perlaky; Dennis R Roop; Anil K Jaiswal
NAD(P)H:quinone oxidoreductase 1 deficiency increases susceptibility to benzo(a)pyrene-induced mouse skin carcinogenesis.
Cancer research 2000;60(21):5913-5.
2000: Y Suga; Michal Jarnik; P S Attar; Mary A Longley; Donnie Bundman; Alasdair C Steven; Peter J Koch; Dennis R Roop
Transgenic mice expressing a mutant form of loricrin reveal the molecular basis of the skin diseases, Vohwinkel syndrome and progressive symmetric erythrokeratoderma.
The Journal of cell biology 2000;151(2):401-12.
2000: Peter J Koch; Pierre A de Viragh; E Scharer; Donnie Bundman; Mary A Longley; Jackie R Bickenbach; Y Kawachi; Y Suga; Zhijian Zhou; Marcel Huber; Daniel Hohl; T Kartasova; Michal Jarnik; Alasdair C Steven; Dennis R Roop
Lessons from loricrin-deficient mice: compensatory mechanisms maintaining skin barrier function in the absence of a major cornified envelope protein.
The Journal of cell biology 2000;151(2):389-400.
2000: Xiao-Jing Wang; DA Greenhalgh; Lawrence A Donehower; Dennis R Roop
Cooperation between Ha-ras and fos or transforming growth factor alpha overcomes a paradoxic tumor-inhibitory effect of p53 loss in transgenic mouse epidermis.
Molecular carcinogenesis 2000;29(2):67-75.
2000: KM Liefer; Maranke I Koster; Xiao-Jing Wang; A Yang; F McKeon; Dennis R Roop
Down-regulation of p63 is required for epidermal UV-B-induced apoptosis.
Cancer research 2000;60(15):4016-20.
2000: SM Wojcik; Donnie Bundman; Dennis R Roop
Delayed wound healing in keratin 6a knockout mice.
Molecular and cellular biology 2000;20(14):5248-55.
2000: Xiao-Jing Wang; DA Greenhalgh; Dennis R Roop
Transgenic coexpression of v-Ha-ras and transforming growth factor alpha increases epidermal hyperproliferation and tumorigenesis and predisposes to malignant conversion via endogenous c-Ha-ras activation.
Molecular carcinogenesis 2000;27(3):200-9.
2000: Meral J Arin; Mary A Longley; Ervin H Epstein; Joseph A Rothnagel; Dennis R Roop
Identification of a novel mutation in keratin 1 in a family with epidermolytic hyperkeratosis.
Experimental dermatology 2000;9(1):16-9.
2000: Y Suga; Meral J Arin; G Scott; lowell goldsmith; C M Magro; LA Baden; Howard P Baden; Dennis R Roop
Hot spot mutations in keratin 2e suggest a correlation between genotype and phenotype in patients with ichthyosis bullosa of Siemens.
Experimental dermatology 2000;9(1):11-5.
2000: T R Berton; Xiao-Jing Wang; Zhijian Zhou; C Kellendonk; G Schütz; S Tsai; Dennis R Roop
Characterization of an inducible, epidermal-specific knockout system: differential expression of lacZ in different Cre reporter mouse strains.
Genesis (New York, N.Y. : 2000) 2000;26(2):160-1.
1999: Xiao-Jing Wang; KM Liefer; DA Greenhalgh; Dennis R Roop
12-O-tetradecanoylphorbol-13-acetate promotion of transgenic mouse epidermis coexpressing transforming growth factor-alpha and v-fos: acceleration of autonomous papilloma formation and malignant conversion via c-Ha-ras activation.
Molecular carcinogenesis 1999;26(4):305-11.
1999: Joseph A Rothnagel; T Seki; M Ogo; Mary A Longley; SM Wojcik; Donnie Bundman; Jackie R Bickenbach; Dennis R Roop
The mouse keratin 6 isoforms are differentially expressed in the hair follicle, footpad, tongue and activated epidermis.
Differentiation; research in biological diversity 1999;65(2):119-30.
1999: SM Wojcik; Sumihisa Imakado; T Seki; Mary A Longley; L Petherbridge; Donnie Bundman; Jackie R Bickenbach; Joseph A Rothnagel; Dennis R Roop
Expression of MK6a dominant-negative and C-terminal mutant transgenes in mice has distinct phenotypic consequences in the epidermis and hair follicle.
Differentiation; research in biological diversity 1999;65(2):97-112.
1999: RL Waikel; Xiao-Jing Wang; Dennis R Roop
Targeted expression of c-Myc in the epidermis alters normal proliferation, differentiation and UV-B induced apoptosis.
Oncogene 1999;18(34):4870-8.
1999: Xiao-Jing Wang; KM Liefer; S Tsai; Bert W O'Malley; Dennis R Roop
Development of gene-switch transgenic mice that inducibly express transforming growth factor beta1 in the epidermis.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(15):8483-8.
1999: D DiSepio; Jackie R Bickenbach; Mary A Longley; Donnie Bundman; Joseph A Rothnagel; Dennis R Roop
Characterization of loricrin regulation in vitro and in transgenic mice.
Differentiation; research in biological diversity 1999;64(4):225-35.
1999: Alea A Mills; B Zheng; Xiao-Jing Wang; H Vogel; Dennis R Roop; Allan Bradley
p63 is a p53 homologue required for limb and epidermal morphogenesis.
Nature 1999;398(6729):708-13.
1999: Meral J Arin; Mary A Longley; Wolfgang Küster; Marcel Huber; Daniel Hohl; Joseph A Rothnagel; Dennis R Roop
An asparagine to threonine substitution in the 1A domain of keratin 1: a novel mutation that causes epidermolytic hyperkeratosis.
Experimental dermatology 1999;8(2):124-7.
1999: M T Lin; Moise L Levy; P E Bowden; C Magro; LA Baden; Howard P Baden; Dennis R Roop
Identification of sporadic mutations in the helix initiation motif of keratin 6 in two pachyonychia congenita patients: further evidence for a mutational hot spot.
Experimental dermatology 1999;8(2):115-9.
1999: Meral J Arin; Mary A Longley; I Anton-Lamprecht; G Kurze; Marcel Huber; Daniel Hohl; Joseph A Rothnagel; Dennis R Roop
A novel substitution in keratin 10 in epidermolytic hyperkeratosis.
The Journal of investigative dermatology 1999;112(4):506-8.
1999: Meral J Arin; Mary A Longley; Ervin H Epstein; G Scott; lowell goldsmith; Joseph A Rothnagel; Dennis R Roop
A novel mutation in the 1A domain of keratin 2e in ichthyosis bullosa of Siemens.
The Journal of investigative dermatology 1999;112(3):380-2.
1998: Y Suga; Karynne O Duncan; Peter Heald; Dennis R Roop
A novel helix termination mutation in keratin 10 in annular epidermolytic ichthyosis, a variant of bullous congenital ichthyosiform erythroderma.
The Journal of investigative dermatology 1998;111(6):1220-3.
1998: Xiao-Jing Wang; DA Greenhalgh; A Jiang; D He; Ling Zhong; Bill R Brinkley; Dennis R Roop
Analysis of centrosome abnormalities and angiogenesis in epidermal-targeted p53172H mutant and p53-knockout mice after chemical carcinogenesis: evidence for a gain of function.
Molecular carcinogenesis 1998;23(3):185-92.
1998: Joseph A Rothnagel; M T Lin; Mary A Longley; R A Holder; P G Hazen; M L Levy; Dennis R Roop
Prenatal diagnosis for keratin mutations to exclude transmission of epidermolytic hyperkeratosis.
Prenatal diagnosis 1998;18(8):826-30.
1998: Xiao-Jing Wang; DA Greenhalgh; A Jiang; D He; Ling Zhong; Daniel Medina; Bill R Brinkley; Dennis R Roop
Expression of a p53 mutant in the epidermis of transgenic mice accelerates chemical carcinogenesis.
Oncogene 1998;17(1):35-45.
1998: B Bonnekoh; DA Greenhalgh; SH Chen; A Block; S S Rich; T Krieg; SL Woo; Dennis R Roop
Ex vivo and in vivo adenovirus-mediated gene therapy strategies induce a systemic anti-tumor immune defence in the B16 melanoma model.
The Journal of investigative dermatology 1998;110(6):867-71.
1998: B Bonnekoh; DA Greenhalgh; SH Chen; Jackie R Bickenbach; A Block; S S Rich; T Krieg; SL Woo; Dennis R Roop
Adenovirus-mediated ex vivo immunogene and in vivo combination gene therapy strategies induce a systemic anti-tumor immune defense in the mouse B16 melanoma model.
Advances in experimental medicine and biology 1998;451():335-43.
1997: P S Attar; Philip W Wertz; M McArthur; Sumihisa Imakado; Jackie R Bickenbach; Dennis R Roop
Inhibition of retinoid signaling in transgenic mice alters lipid processing and disrupts epidermal barrier function.
Molecular endocrinology (Baltimore, Md.) 1997;11(6):792-800.
1997: Xiao-Jing Wang; DA Greenhalgh; Jackie R Bickenbach; A Jiang; Donnie Bundman; T Krieg; Rik Derynck; Dennis R Roop
Expression of a dominant-negative type II transforming growth factor beta (TGF-beta) receptor in the epidermis of transgenic mice blocks TGF-beta-mediated growth inhibition.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(6):2386-91.
1997: G Y Joh; H Traupe; D Metze; D Nashan; Marcel Huber; Daniel Hohl; Mary A Longley; Joseph A Rothnagel; Dennis R Roop
A novel dinucleotide mutation in keratin 10 in the annular epidermolytic ichthyosis variant of bullous congenital ichthyosiform erythroderma.
The Journal of investigative dermatology 1997;108(3):357-61.
1997: B Bonnekoh; Jackie R Bickenbach; Dennis R Roop
Immunological gene therapy approaches for malignant melanoma. 2. Preclinical studies and clinical strategies.
Skin pharmacology : the official journal of the Skin Pharmacology Society 1997;10(3):105-25.
1997: B Bonnekoh; Jackie R Bickenbach; Dennis R Roop
Immunological gene therapy approaches for malignant melanoma. 1. Tumor-immunological background.
Skin pharmacology : the official journal of the Skin Pharmacology Society 1997;10(2):49-62.
1996: Jackie R Bickenbach; Mary A Longley; Donnie Bundman; A M Dominey; P E Bowden; Joseph A Rothnagel; Dennis R Roop
A transgenic mouse model that recapitulates the clinical features of both neonatal and adult forms of the skin disease epidermolytic hyperkeratosis.
Differentiation; research in biological diversity 1996;61(2):129-39.
1996: DA Greenhalgh; Xiao-Jing Wang; L A Donehower; Dennis R Roop
Paradoxical tumor inhibitory effect of p53 loss in transgenic mice expressing epidermal-targeted v-rasHa, v-fos, or human transforming growth factor alpha.
Cancer research 1996;56(19):4413-23.
1996: DA Greenhalgh; Xiao-Jing Wang; Dennis R Roop
Multistage epidermal carcinogenesis in transgenic mice: cooperativity and paradox.
The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 1996;1(2):162-76.
1995: DA Greenhalgh; Xiao-Jing Wang; Dennis R Roop
Multistage skin carcinogenesis in transgenic mice.
Proceedings of the Association of American Physicians 1995;107(2):258-75.
1995: D DiSepio; A Jones; Mary A Longley; Donnie Bundman; Joseph A Rothnagel; Dennis R Roop
The proximal promoter of the mouse loricrin gene contains a functional AP-1 element and directs keratinocyte-specific but not differentiation-specific expression.
The Journal of biological chemistry 1995;270(18):10792-9.
1995: DA Greenhalgh; Xiao-Jing Wang; J N Eckhardt; Dennis R Roop
12-O-tetradecanoylphorbol-13-acetate promotion of transgenic mice expressing epidermal-targeted v-fos induces rasHA-activated papillomas and carcinomas without p53 mutation: association of v-fos expression with promotion and tumor autonomy.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995;6(5):579-86.
1995: Joseph A Rothnagel; Dennis R Roop
Hair follicle companion layer: reacquainting an old friend.
The Journal of investigative dermatology 1995;104(5 Suppl):42S-43S.
1995: Martin M Matzuk; N Lu; H Vogel; K Sellheyer; Dennis R Roop; Allan Bradley
Multiple defects and perinatal death in mice deficient in follistatin.
Nature 1995;374(6520):360-3.
1995: Martin M Matzuk; T Rajendra Kumar; Anne Vassalli; Jackie R Bickenbach; Dennis R Roop; Rudolf Jaenisch; Allan Bradley
Functional analysis of activins during mammalian development.
Nature 1995;374(6520):354-6.
1995: Jackie R Bickenbach; J M Greer; Donnie Bundman; Joseph A Rothnagel; Dennis R Roop
Loricrin expression is coordinated with other epidermal proteins and the appearance of lipid lamellar granules in development.
The Journal of investigative dermatology 1995;104(3):405-10.
1995: B Bonnekoh; DA Greenhalgh; Donnie Bundman; J N Eckhardt; Mary A Longley; SH Chen; SL Woo; Dennis R Roop
Inhibition of melanoma growth by adenoviral-mediated HSV thymidine kinase gene transfer in vivo.
The Journal of investigative dermatology 1995;104(3):313-7.
1995: Joseph A Rothnagel; SM Wojcik; K M Liefer; A M Dominey; Marcel Huber; Daniel Hohl; Dennis R Roop
Mutations in the 1A domain of keratin 9 in patients with epidermolytic palmoplantar keratoderma.
The Journal of investigative dermatology 1995;104(3):430-3.
1995: Dennis R Roop
Defects in the barrier.
Science (New York, N.Y.) 1995;267(5197):474-5.
1995: Xiao-Jing Wang; DA Greenhalgh; X R Lu; Jackie R Bickenbach; Dennis R Roop
TGF alpha and v-fos cooperation in transgenic mouse epidermis induces aberrant keratinocyte differentiation and stable, autonomous papillomas.
Oncogene 1995;10(2):279-89.
1994: DA Greenhalgh; Joseph A Rothnagel; Dennis R Roop
Epidermis: an attractive target tissue for gene therapy.
The Journal of investigative dermatology 1994;103(5 Suppl):63S-69S.
1994: Joseph A Rothnagel; Mary A Longley; Donnie Bundman; Susan Naylor; P A Lalley; N A Jenkins; D J Gilbert; N G Copeland; Dennis R Roop
Characterization of the mouse loricrin gene: linkage with profilaggrin and the flaky tail and soft coat mutant loci on chromosome 3.
Genomics 1994;23(2):450-6.
1994: Joseph A Rothnagel; H Traupe; SM Wojcik; Marcel Huber; Daniel Hohl; Mark Pittelkow; H Saeki; Y Ishibashi; Dennis R Roop
Mutations in the rod domain of keratin 2e in patients with ichthyosis bullosa of Siemens.
Nature genetics 1994;7(4):485-90.
1994: Joseph A Rothnagel; Mary A Longley; R A Holder; Donnie Bundman; T Seki; Jackie R Bickenbach; Dennis R Roop
Genetic disorders of keratin: are scarring alopecias a sub-set?
Journal of dermatological science 1994;7 Suppl():S164-9.
1994: DA Greenhalgh; Xiao-Jing Wang; Joseph A Rothnagel; J N Eckhardt; M I Quintanilla; J L Barber; Donnie Bundman; Mary A Longley; R Schlegel; Dennis R Roop
Transgenic mice expressing targeted HPV-18 E6 and E7 oncogenes in the epidermis develop verrucous lesions and spontaneous, rasHa-activated papillomas.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994;5(6):667-75.
1994: Xiao-Jing Wang; DA Greenhalgh; J N Eckhardt; Joseph A Rothnagel; Dennis R Roop
Epidermal expression of transforming growth factor-alpha in transgenic mice: induction of spontaneous and 12-O-tetradecanoylphorbol-13-acetate-induced papillomas via a mechanism independent of Ha-ras activation or overexpression.
Molecular carcinogenesis 1994;10(1):15-22.
1994: Baisong Lu; Joseph A Rothnagel; Mary A Longley; Sophia Y Tsai; Dennis R Roop
Differentiation-specific expression of human keratin 1 is mediated by a composite AP-1/steroid hormone element.
The Journal of biological chemistry 1994;269(10):7443-9.
1994: DA Greenhalgh; Dennis R Roop
Dissecting molecular carcinogenesis: development of transgenic mouse models by epidermal gene targeting.
Advances in cancer research 1994;64():247-96.
1994: DA Greenhalgh; Xiao-Jing Wang; A M Dominey; Joseph A Rothnagel; Dennis R Roop
Development of transgenic mouse models of skin carcinogenesis: potential applications.
Progress in clinical and biological research 1994;387():75-94.
1994: Joseph A Rothnagel; Mary A Longley; R A Holder; W Küster; Dennis R Roop
Prenatal diagnosis of epidermolytic hyperkeratosis by direct gene sequencing.
The Journal of investigative dermatology 1994;102(1):13-6.
1993: Joseph A Rothnagel; M P Fisher; S M Axtell; Mark Pittelkow; I Anton-Lamprecht; Marcel Huber; Daniel Hohl; Dennis R Roop
A mutational hot spot in keratin 10 (KRT 10) in patients with epidermolytic hyperkeratosis.
Human molecular genetics 1993;2(12):2147-50.
1993: Joseph A Rothnagel; DA Greenhalgh; Xiao-Jing Wang; K Sellheyer; Jackie R Bickenbach; A M Dominey; Dennis R Roop
Transgenic models of skin diseases.
Archives of dermatology 1993;129(11):1430-6.
1993: DA Greenhalgh; M I Quintanilla; C C Orengo; J L Barber; J N Eckhardt; Joseph A Rothnagel; Dennis R Roop
Cooperation between v-fos and v-rasHA induces autonomous papillomas in transgenic epidermis but not malignant conversion.
Cancer research 1993;53(21):5071-5.
1993: Joseph A Rothnagel; DA Greenhalgh; T A Gagne; Mary A Longley; Dennis R Roop
Identification of a calcium-inducible, epidermal-specific regulatory element in the 3'-flanking region of the human keratin 1 gene.
The Journal of investigative dermatology 1993;101(4):506-13.
1993: DA Greenhalgh; Joseph A Rothnagel; Xiao-Jing Wang; M I Quintanilla; C C Orengo; T A Gagne; Donnie Bundman; Mary A Longley; C Fisher; Dennis R Roop
Hyperplasia, hyperkeratosis and benign tumor production in transgenic mice by a targeted v-fos oncogene suggest a role for fos in epidermal differentiation and neoplasia.
Oncogene 1993;8(8):2145-57.
1993: K Sellheyer; Jackie R Bickenbach; Joseph A Rothnagel; Donnie Bundman; Mary A Longley; T Krieg; N S Roche; A B Roberts; Dennis R Roop
Inhibition of skin development by overexpression of transforming growth factor beta 1 in the epidermis of transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(11):5237-41.
1993: DA Greenhalgh; Joseph A Rothnagel; M I Quintanilla; C C Orengo; T A Gagne; Donnie Bundman; Mary A Longley; Dennis R Roop
Induction of epidermal hyperplasia, hyperkeratosis, and papillomas in transgenic mice by a targeted v-Ha-ras oncogene.
Molecular carcinogenesis 1993;7(2):99-110.
1992: Joseph A Rothnagel; A M Dominey; L D Dempsey; Mary A Longley; DA Greenhalgh; T A Gagne; Marcel Huber; E Frenk; Daniel Hohl; Dennis R Roop
Mutations in the rod domains of keratins 1 and 10 in epidermolytic hyperkeratosis.
Science (New York, N.Y.) 1992;257(5073):1128-30.
1990: Joseph A Rothnagel; Mary A Longley; Donnie Bundman; DA Greenhalgh; A M Dominey; Dennis R Roop
Targeting gene expression to the epidermis of transgenic mice: potential applications to genetic skin disorders.
The Journal of investigative dermatology 1990;95(5 Suppl):59S-61S.
1990: Joseph A Rothnagel; Mary A Longley; Donnie Bundman; DA Greenhalgh; A M Dominey; Dennis R Roop
Targeting gene expression to the epidermis of transgenic mice: potential applications to genetic skin disorders.
The Journal of investigative dermatology 1990;95(5):59S-61S.