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Bernard Roques

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
92
Fournié-Zaluski, Marie-Claude
56
Noble, Florence
32
de Rocquigny, Hugues
31
Daugé, Valérie
31
Fournie-Zaluski, MC
29
Maldonado, Rafael
25
Mély, Yves
25
Morellet, Nelly
25
Turcaud, Serge
22
Darlix, Jean-Luc
20
Garbay, Christiane
19
Cornille, F
19
Valverde, O
17
DELEPIERRE, Muriel
17
Coric, Pascale

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Publications

TOP 3
González-Rodríguez Sara; Pevida Marta; Roques Bernard P; Fournié-Zaluski Marie-Claude; Hidalgo Agustín; Menéndez Luis; Baamonde Ana
Involvement of enkephalins in the inhibition of osteosarcoma-induced thermal hyperalgesia evoked by the blockade of peripheral P2X3 receptors.
Bourbigot Sarah; Ramalanjaona Nick; Boudier Christian; Salgado Gilmar F J; Roques Bernard P; Mély Yves; Bouaziz Serge; Morellet Nelly
How the HIV-1 nucleocapsid protein binds and destabilises the (-)primer binding site during reverse transcription.
Menéndez Luis; Hidalgo Agustín; Meana Alvaro; Poras Hervé; Fournié-Zaluski Marie-Claude; Roques Bernard P; Baamonde Ana
Inhibition of osteosarcoma-induced thermal hyperalgesia in mice by the orally active dual enkephalinase inhibitor PL37. Potentiation by gabapentin.

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All Publications

2009: González-Rodríguez Sara; Pevida Marta; Roques Bernard P; Fournié-Zaluski Marie-Claude; Hidalgo Agustín; Menéndez Luis; Baamonde Ana
Involvement of enkephalins in the inhibition of osteosarcoma-induced thermal hyperalgesia evoked by the blockade of peripheral P2X3 receptors.
Neuroscience letters 2009;465(3):285-9.
2008: Bourbigot Sarah; Ramalanjaona Nick; Boudier Christian; Salgado Gilmar F J; Roques Bernard P; Mély Yves; Bouaziz Serge; Morellet Nelly
How the HIV-1 nucleocapsid protein binds and destabilises the (-)primer binding site during reverse transcription.
Journal of molecular biology 2008;383(5):1112-28.
2008: Menéndez Luis; Hidalgo Agustín; Meana Alvaro; Poras Hervé; Fournié-Zaluski Marie-Claude; Roques Bernard P; Baamonde Ana
Inhibition of osteosarcoma-induced thermal hyperalgesia in mice by the orally active dual enkephalinase inhibitor PL37. Potentiation by gabapentin.
European journal of pharmacology 2008;596(1-3):50-5.
2008: Gao Lu; Hanson Mark Nils; Balakrishnan Mini; Boyer Paul L; Roques Bernard P; Hughes Stephen H; Kim Baek; Bambara Robert A
Apparent defects in processive DNA synthesis, strand transfer, and primer elongation of Met-184 mutants of HIV-1 reverse transcriptase derive solely from a dNTP utilization defect.
The Journal of biological chemistry 2008;283(14):9196-205.
2008: Padia Shetal H; Kemp Brandon A; Howell Nancy L; Fournie-Zaluski Marie-Claude; Roques Bernard P; Carey Robert M
Conversion of renal angiotensin II to angiotensin III is critical for AT2 receptor-mediated natriuresis in rats.
Hypertension 2008;51(2):460-5.
2008: Song Min; Basu Vandana P; Hanson Mark N; Roques Bernard P; Bambara Robert A
Proximity and branch migration mechanisms in HIV-1 minus strand strong stop DNA transfer.
The Journal of biological chemistry 2008;283(6):3141-50.
2008: Noble Florence; Benturquia Nadia; Bilkei-Gorzo Andras; Zimmer Andreas; Roques Bernard P
Use of preproenkephalin knockout mice and selective inhibitors of enkephalinases to investigate the role of enkephalins in various behaviours.
Psychopharmacology 2008;196(2):327-35.
2008: Siddiqui K; Del Valle L; Morellet N; Cui J; Ghafouri M; Mukerjee R; Urbanska K; Fan S; Pattillo C B; Deshmane S L; Kiani M F; Ansari R; Khalili K; Roques B P; Reiss K; Bouaziz S; Amini S; Srinivasan A; Sawaya B E
Molecular mimicry in inducing DNA damage between HIV-1 Vpr and the anticancer agent, cisplatin.
Oncogene 2008;27(1):32-43.
2007: Benturquia N; Le Guen S; Canestrelli C; Lagente V; Apiou G; Roques B P; Noble F
Specific blockade of morphine- and cocaine-induced reinforcing effects in conditioned place preference by nitrous oxide in mice.
Neuroscience 2007;149(3):477-86.
2007: Bombarda Elisa; Grell Ernst; Roques Bernard P; Mély Yves
Molecular mechanism of the Zn2+-induced folding of the distal CCHC finger motif of the HIV-1 nucleocapsid protein.
Biophysical journal 2007;93(1):208-17.
2007: Padia Shetal H; Kemp Brandon A; Howell Nancy L; Siragy Helmy M; Fournie-Zaluski Marie-Claude; Roques Bernard P; Carey Robert M
Intrarenal aminopeptidase N inhibition augments natriuretic responses to angiotensin III in angiotensin type 1 receptor-blocked rats.
Hypertension 2007;49(3):625-30.
2007: Marie-Claire Cynthia; Courtin Cindie; Robert Amelie; Gidrol Xavier; Roques Bernard P; Noble Florence
Sensitization to the conditioned rewarding effects of morphine modulates gene expression in rat hippocampus.
Neuropharmacology 2007;52(2):430-5.
2006: Jardinaud Fanny; Roques Bernard P; Noble Florence
Tolerance to the reinforcing effects of morphine in delta9-tetrahydrocannabinol treated mice.
Behavioural brain research 2006;173(2):255-61.
2006: Sabbah Emmanuelle N; Delaunay Thierry; Varin Audrey; Le-Rouzic Erwann; Benichou Serge; Herbein Georges; Druillennec Sabine; Roques Bernard P
Development and characterization of ten monoclonal anti-Vpr antibodies.
AIDS research and human retroviruses 2006;22(7):630-9.
2006: Sihn Gabin; Savary Katia; Michaud Annie; Fournie-Zaluski Marie-Claude; Roques Bernard P; Corvol Pierre; Gasc Jean-Marie
Aminopeptidase N during the ontogeny of the chick.
Differentiation; research in biological diversity 2006;74(2-3):119-28.
2006: Sabbah Emmanuelle N; Druillennec S; Morellet N; Bouaziz S; Kroemer G; Roques B P
Interaction between the HIV-1 protein Vpr and the adenine nucleotide translocator.
Chemical biology & drug design 2006;67(2):145-54.
2006: Morellet Nelly; Meudal Hervé; Bouaziz Serge; Roques Bernard Pierre
Structure of the zinc finger domain encompassing residues 13-51 of the nucleocapsid protein from simian immunodeficiency virus.
The Biochemical journal 2006;393(Pt 3):725-32.
2005: Sabbah Emmanuelle N; Roques Bernard P
Critical implication of the (70-96) domain of human immunodeficiency virus type 1 Vpr protein in apoptosis of primary rat cortical and striatal neurons.
Journal of neurovirology 2005;11(6):489-502.
2005: Varin Audrey; Decrion Anne-Zélie; Sabbah Emmanuelle; Quivy Vincent; Sire Joséphine; Van Lint Carine; Roques Bernard P; Aggarwal Bharat B; Herbein Georges
Synthetic Vpr protein activates activator protein-1, c-Jun N-terminal kinase, and NF-kappaB and stimulates HIV-1 transcription in promonocytic cells and primary macrophages.
The Journal of biological chemistry 2005;280(52):42557-67.
2005: Jardinaud Fanny; Crété Dominique; Canestrelli Corinne; Ledent Catherine; Roques Bernard P; Noble Florence
CB1 receptor knockout mice show similar behavioral modifications to wild-type mice when enkephalin catabolism is inhibited.
Brain research 2005;1063(1):77-83.
2005: Anne Christine; Turcaud Serge; Blommaert Armand G S; Darchen François; Johnson Eric A; Roques Bernard P
Partial protection against Botulinum B neurotoxin-induced blocking of exocytosis by a potent inhibitor of its metallopeptidase activity.
Chembiochem : a European journal of chemical biology 2005;6(8):1375-80.
2005: Bombarda Elisa; Roques Bernard P; Mély Yves; Grell Ernst
Mechanism of zinc coordination by point-mutated structures of the distal CCHC binding motif of the HIV-1 NCp7 protein.
Biochemistry 2005;44(19):7315-25.
2005: Beltz Hervé; Clauss Céline; Piémont Etienne; Ficheux Damien; Gorelick Robert J; Roques Bernard; Gabus Caroline; Darlix Jean-Luc; de Rocquigny Hugues; Mély Yves
Structural determinants of HIV-1 nucleocapsid protein for cTAR DNA binding and destabilization, and correlation with inhibition of self-primed DNA synthesis.
Journal of molecular biology 2005;348(5):1113-26.
2005: Reaux-Le Goazigo Annabelle; Iturrioz Xavier; Fassot Celine; Claperon Cedric; Roques Bernard P; Llorens-Cortes Catherine
Role of angiotensin III in hypertension.
Current hypertension reports 2005;7(2):128-34.
2005: Bourbigot Sarah; Beltz Hervé; Denis Jérôme; Morellet Nelly; Roques Bernard P; Mély Yves; Bouaziz Serge
The C-terminal domain of the HIV-1 regulatory protein Vpr adopts an antiparallel dimeric structure in solution via its leucine-zipper-like domain.
The Biochemical journal 2005;387(Pt 2):333-41.
2005: Inguimbert N; Coric P; Dhotel H; Bonnard E; Llorens-Cortes C; Mota N; Fournié-Zaluski M-C; Roques B-P
Synthesis and in vitro activities of new non-peptidic APA inhibitors.
The journal of peptide research : official journal of the American Peptide Society 2005;65(2):175-88.
2005: Morellet Nelly; Druillennec Sabine; Lenoir Christine; Bouaziz Serge; Roques Bernard P
Helical structure determined by NMR of the HIV-1 (345-392)Gag sequence, surrounding p2: implications for particle assembly and RNA packaging.
Protein science : a publication of the Protein Society 2005;14(2):375-86.
2005: Nieto M Mas; Guen S L E; Kieffer B L; Roques B P; Noble F
Physiological control of emotion-related behaviors by endogenous enkephalins involves essentially the delta opioid receptors.
Neuroscience 2005;135(2):305-13.
2005: Cordonnier L; Sanchez M; Roques B P; Noble F
Facilitation of enkephalins-induced delta-opioid behavioral responses by chronic amisulpride treatment.
Neuroscience 2005;135(1):1-10.
2004: Marie-Claire Cynthia; Courtin Cindie; Roques Bernard P; Noble Florence
Cytoskeletal genes regulation by chronic morphine treatment in rat striatum.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2004;29(12):2208-15.
2004: Egelé Caroline; Schaub Emmanuel; Ramalanjaona Nick; Piémont Etienne; Ficheux Damien; Roques Bernard; Darlix Jean-Luc; Mély Yves
HIV-1 nucleocapsid protein binds to the viral DNA initiation sequences and chaperones their kissing interactions.
Journal of molecular biology 2004;342(2):453-66.
2004: Stote Roland H; Kellenberger Esther; Muller Hervé; Bombarda Elisa; Roques Bernard P; Kieffer Bruno; Mély Yves
Structure of the His44 --> Ala single point mutant of the distal finger motif of HIV-1 nucleocapsid protein: a combined NMR, molecular dynamics simulation, and fluorescence study.
Biochemistry 2004;43(24):7687-97.
2004: Ramboarina S; Druillennec S; Morellet N; Bouaziz S; Roques B P
Target specificity of human immunodeficiency virus type 1 NCp7 requires an intact conformation of its CCHC N-terminal zinc finger.
Journal of virology 2004;78(12):6682-7.
2004: Blommaert Armand; Turcaud Serge; Anne Christine; Roques Bernard P
Small tripeptide surrogates with low nanomolar affinity as potent inhibitors of the botulinum neurotoxin B metallo-proteolytic activity.
Bioorganic & medicinal chemistry 2004;12(11):3055-62.
2004: Fournie-Zaluski Marie-Claude; Fassot Celine; Valentin Bruno; Djordjijevic Dragan; Reaux-Le Goazigo Annabelle; Corvol Pierre; Roques Bernard P; Llorens-Cortes Catherine
Brain renin-angiotensin system blockade by systemically active aminopeptidase A inhibitors: a potential treatment of salt-dependent hypertension.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(20):7775-80.
2004: Beltz Hervé; Piémont Etienne; Schaub Emmanuel; Ficheux Damien; Roques Bernard; Darlix Jean-Luc; Mély Yves
Role of the structure of the top half of HIV-1 cTAR DNA on the nucleic acid destabilizing activity of the nucleocapsid protein NCp7.
Journal of molecular biology 2004;338(4):711-23.
2004: Jardinaud Fanny; Banisadr Ghasal; Noble Florence; Mélik-Parsadaniantz Stéphane; Chen Huixiong; Dugave Christophe; Laplace Hervé; Rostène William; Fournié-Zaluski Marie-Claude; Roques Bernard P; Popovici Théodora
Ontogenic and adult whole body distribution of aminopeptidase N in rat investigated by in vitro autoradiography.
Biochimie 2004;86(2):105-13.
2004: Inguimbert N; Poras H; Dhotel H; Beslot F; Scalbert E; Bennejean C; Renard P; Fournié-Zaluski M-C; Roques B-P
In vivo properties of thiol inhibitors of the three vasopeptidases NEP, ACE and ECE are improved by introduction of a 7-azatryptophan in P2' position.
The journal of peptide research : official journal of the American Peptide Society 2004;63(2):99-107.
2004: Oefner Christian; Roques Bernard P; Fournie-Zaluski Marie-Claude; Dale Glenn E
Structural analysis of neprilysin with various specific and potent inhibitors.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 2):392-6.
2004: Tisné Carine; Roques Bernard P; Dardel Frédéric
The annealing mechanism of HIV-1 reverse transcription primer onto the viral genome.
The Journal of biological chemistry 2004;279(5):3588-95.
2003: Noble Florence; Roques Bernard P
The role of CCK2 receptors in the homeostasis of the opioid system.
Drugs of today (Barcelona, Spain : 1998) 2003;39(11):897-908.
2003: Salzmann Julie; Marie-Claire Cynthia; Le Guen Stephanie; Roques Bernard P; Noble Florence
Importance of ERK activation in behavioral and biochemical effects induced by MDMA in mice.
British journal of pharmacology 2003;140(5):831-8.
2003: Anne Christine; Turcaud Serge; Quancard Jean; Teffo Franck; Meudal Hervé; Fournié-Zaluski Marie-Claude; Roques Bernard P
Development of potent inhibitors of botulinum neurotoxin type B.
Journal of medicinal chemistry 2003;46(22):4648-56.
2003: Anne Christine; Blommaert Armand; Turcaud Serge; Martin Anne-Sophie; Meudal Hervé; Roques Bernard P
Thio-derived disulfides as potent inhibitors of botulinum neurotoxin type B: implications for zinc interaction.
Bioorganic & medicinal chemistry 2003;11(21):4655-60.
2003: Krishnamoorthy G; Roques Bernard; Darlix Jean-Luc; Mély Yves
DNA condensation by the nucleocapsid protein of HIV-1: a mechanism ensuring DNA protection.
Nucleic acids research 2003;31(18):5425-32.
2003: Le Guen Stéphanie; Mas Nieto Magdalena; Canestrelli Corinne; Chen Huixiong; Fournié-Zaluski Marie-Claude; Cupo Annie; Maldonado Rafaël; Roques Bernard P; Noble Florence
Pain management by a new series of dual inhibitors of enkephalin degrading enzymes: long lasting antinociceptive properties and potentiation by CCK2 antagonist or methadone.
Pain 2003;104(1-2):139-48.
2003: Selkti Mohamed; Tomas Alain; Gaucher Jean-François; Prangé Thierry; Fournié-Zaluski Marie-Claude; Chen Huixiong; Roques Bernard-Pierre
Interactions of a new alpha-aminophosphinic derivative inside the active site of TLN (thermolysin): a model for zinc-metalloendopeptidase inhibition.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 7):1200-5.
2003: Marie-Claire Cynthia; Laurendeau Ingrid; Canestrelli Corine; Courtin Cindie; Vidaud Michel; Roques Bernard; Noble Florence
Fos but not Cart (cocaine and amphetamine regulated transcript) is overexpressed by several drugs of abuse: a comparative study using real-time quantitative polymerase chain reaction in rat brain.
Neuroscience letters 2003;345(2):77-80.
2003: Poljak Leonora; Batson Susan M; Ficheux Damien; Roques Bernard P; Darlix Jean-Luc; Käs Emmanuel
Analysis of NCp7-dependent activation of HIV-1 cDNA integration and its conservation among retroviral nucleocapsid proteins.
Journal of molecular biology 2003;329(3):411-21.
2003: Tisné Carine; Roques Bernard P; Dardel Frédéric
Specific recognition of primer tRNA Lys 3 by HIV-1 nucleocapsid protein: involvement of the zinc fingers and the N-terminal basic extension.
Biochimie 2003;85(5):557-61.
2003: Bischerour Julien; Tauc Patrick; Leh Hervé; de Rocquigny Hugues; Roques Bernard; Mouscadet Jean-François
The (52-96) C-terminal domain of Vpr stimulates HIV-1 IN-mediated homologous strand transfer of mini-viral DNA.
Nucleic acids research 2003;31(10):2694-702.
2003: Roques B P; Noble F
[Plusridisciplinary approaches to understand the neutoxic effects of Ecstasy]
Annales pharmaceutiques françaises 2003;61(3):157-63.
2003: Beltz Hervé; Azoulay Joel; Bernacchi Serena; Clamme Jean-Pierre; Ficheux Damien; Roques Bernard; Darlix Jean-Luc; Mély Yves
Impact of the terminal bulges of HIV-1 cTAR DNA on its stability and the destabilizing activity of the nucleocapsid protein NCp7.
Journal of molecular biology 2003;328(1):95-108.
2003: Pommier Blandine; Marie-Claire Cynthia; Da Nascimento Sophie; Wang Hung-Li; Roques Bernard P; Noble Florence
Further evidence that the CCK2 receptor is coupled to two transduction pathways using site-directed mutagenesis.
Journal of neurochemistry 2003;85(2):454-61.
2003: Le Guen Stéphanie; Catheline Gwénaëlle; Fournié-Zaluski Marie Claude; Roques Bernard Pierre; Besson Jean Marie; Buritova Jaroslava
Further evidence for the interaction of mu- and delta-opioid receptors in the antinociceptive effects of the dual inhibitor of enkephalin catabolism, RB101(S). A spinal c-Fos protein study in the rat under carrageenin inflammation.
Brain research 2003;967(1-2):106-12.
2003: Morellet N; Bouaziz S; Petitjean P; Roques B P
NMR structure of the HIV-1 regulatory protein VPR.
Journal of molecular biology 2003;327(1):215-27.
2003: Azoulay Joel; Clamme Jean Pierre; Darlix Jean Luc; Roques Bernard P; Mély Yves
Destabilization of the HIV-1 complementary sequence of TAR by the nucleocapsid protein through activation of conformational fluctuations.
Journal of molecular biology 2003;326(3):691-700.
2003: Rozenfeld Raphael; Reaux Annabelle; Iturrioz Xavier; Fassot Celine; Fournie-Zaluski Marie-Claude; David Christelle; Maigret Bernard; Roques Bernard Pierre; Corvol Pierre; Llorens-Cortes Catherine
Aminopeptidase A, generating one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, plays a key role in central control of blood pressure.
Proceedings of the Western Pharmacology Society 2003;46():39-44.
2003: Buritova Jaroslava; Le Guen Stéphanie; Fournié-Zaluski Marie-Claude; Roques Bernard P; Besson Jean-Marie
Antinociceptive effects of RB101(S), a complete inhibitor of enkephalin-catabolizing enzymes, are enhanced by (+)-HA966, a functional NMDA receptor antagonist: a c-Fos study in the rat spinal cord.
European journal of pain (London, England) 2003;7(3):241-9.
2003: Daugé V; Pophillat M; Crété D; Melik-Parsadaniantz S; Roques B P
Involvement of brain endogenous cholecystokinin in stress-induced impairment of spatial recognition memory.
Neuroscience 2003;118(1):19-23.
2002: Roumier T; Vieira H L A; Castedo M; Ferri K F; Boya P; Andreau K; Druillennec S; Joza N; Penninger J M; Roques B; Kroemer G
The C-terminal moiety of HIV-1 Vpr induces cell death via a caspase-independent mitochondrial pathway.
Cell death and differentiation 2002;9(11):1212-9.
2002: Wecker K; Morellet N; Bouaziz S; Roques B P
NMR structure of the HIV-1 regulatory protein Vpr in H2O/trifluoroethanol. Comparison with the Vpr N-terminal (1-51) and C-terminal (52-96) domains.
European journal of biochemistry / FEBS 2002;269(15):3779-88.
2002: Castedo Maria; Roumier Thomas; Blanco Julià; Ferri Karine F; Barretina Jordi; Tintignac Lionel A; Andreau Karine; Perfettini Jean-Luc; Amendola Alessandra; Nardacci Roberta; Leduc Philip; Ingber Donald E; Druillennec Sabine; Roques Bernard; Leibovitch Serge A; Vilella-Bach Montserrat; Chen Jie; Este José A; Modjtahedi Nazanine; Piacentini Mauro; Kroemer Guido
Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope.
The EMBO journal 2002;21(15):4070-80.
2002: Inguimbert Nicolas; Poras Hervé; Teffo Franck; Beslot Françoise; Selkti Mohamed; Tomas Alain; Scalbert Elizabeth; Bennejean Caroline; Renard Pierre; Fournié-Zaluski Marie-Claude; Roques Bernard-Pierre
N-[2-(Indan-1-yl)-3-mercapto-propionyl] amino acids as highly potent inhibitors of the three vasopeptidases (NEP, ACE, ECE): In vitro and In vivo activities.
Bioorganic & medicinal chemistry letters 2002;12(15):2001-5.
2002: Noble F; Roques B P
Phenotypes of mice with invalidation of cholecystokinin (CCK(1) or CCK(2)) receptors.
Neuropeptides 2002;36(2-3):157-70.
2002: Le Guen Stéphanie; Noble Florence; Fournié-Zaluski Marie-Claude; Roques Bernard Pierre; Besson Jean-Marie; Buritova Jaroslava
RB101(S), a dual inhibitor of enkephalinases does not induce antinociceptive tolerance, or cross-tolerance with morphine: a c-Fos study at the spinal level.
European journal of pharmacology 2002;441(3):141-50.
2002: de Soultrait Vaea Richard; Caumont Anne; Parissi Vincent; Morellet Nelly; Ventura Michel; Lenoir Christine; Litvak Simon; Fournier Michel; Roques Bernard
A novel short peptide is a specific inhibitor of the human immunodeficiency virus type 1 integrase.
Journal of molecular biology 2002;318(1):45-58.
2002: Bombarda E; Cherradi H; Morellet N; Roques B P; Mély Y
Zn(2+) binding properties of single-point mutants of the C-terminal zinc finger of the HIV-1 nucleocapsid protein: evidence of a critical role of cysteine 49 in Zn(2+) dissociation.
Biochemistry 2002;41(13):4312-20.
2002: Vieira Helena L A; Boya Patricia; Cohen Isabelle; El Hamel Chahrazed; Haouzi Delphine; Druillenec Sabine; Belzacq Anne-Sophie; Brenner Catherine; Roques Bernard; Kroemer Guido
Cell permeable BH3-peptides overcome the cytoprotective effect of Bcl-2 and Bcl-X(L).
Oncogene 2002;21(13):1963-77.
2002: Bernacchi Serena; Stoylov Stoyl; Piémont Etienne; Ficheux Damien; Roques Bernard P; Darlix Jean Luc; Mély Yves
HIV-1 nucleocapsid protein activates transient melting of least stable parts of the secondary structure of TAR and its complementary sequence.
Journal of molecular biology 2002;317(3):385-99.
2002: Inguimbert Nicolas; Coric Pascale; Poras Hervé; Meudal Hervé; Teffot Franck; Fournié-Zaluski Marie-Claude; Roques Bernard P
Toward an optimal joint recognition of the S1' subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase (NEP).
Journal of medicinal chemistry 2002;45(7):1477-86.
2002: Pommier Blandine; Beslot Françoise; Simon Axelle; Pophillat Matthieu; Matsui Toshimitsu; Dauge Valérie; Roques Bernard P; Noble Florence
Deletion of CCK2 receptor in mice results in an upregulation of the endogenous opioid system.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(5):2005-11.
2002: Ramboarina Stéphanie; Srividya Narayanan; Atkinson R Andrew; Morellet Nelly; Roques Bernard P; Lefèvre Jean-François; Mély Yves; Kieffer Bruno
Effects of temperature on the dynamic behaviour of the HIV-1 nucleocapsid NCp7 and its DNA complex.
Journal of molecular biology 2002;316(3):611-27.
2002: Nioche Pierre; Liu Wang-Qing; Broutin Isabelle; Charbonnier Franck; Latreille Marie-Thérèse; Vidal Michel; Roques Bernard; Garbay Christiane; Ducruix Arnaud
Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor.
Journal of molecular biology 2002;315(5):1167-77.
2002: Nieto Magdalena Mas; Wilson Jodie; Cupo Annie; Roques Bernard P; Noble Florence
Chronic morphine treatment modulates the extracellular levels of endogenous enkephalins in rat brain structures involved in opiate dependence: a microdialysis study.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(3):1034-41.
2001: Rong L; Liang C; Hsu M; Guo X; Roques B P; Wainberg M A
HIV-1 nucleocapsid protein and the secondary structure of the binary complex formed between tRNA(Lys.3) and viral RNA template play different roles during initiation of (-) strand DNA reverse transcription.
The Journal of biological chemistry 2001;276(50):47725-32.
2001: Daugé V; Sebret A; Beslot F; Matsui T; Roques B P
Behavioral profile of CCK2 receptor-deficient mice.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2001;25(5):690-8.
2001: Chen H; Noble F; Roques B P; Fournié-Zaluski M C
Long lasting antinociceptive properties of enkephalin degrading enzyme (NEP and APN) inhibitor prodrugs.
Journal of medicinal chemistry 2001;44(21):3523-30.
2001: Nieto M M; Wilson J; Walker J; Benavides J; Fournié-Zaluski M C; Roques B P; Noble F
Facilitation of enkephalins catabolism inhibitor-induced antinociception by drugs classically used in pain management.
Neuropharmacology 2001;41(4):496-506.
2001: Boya P; Roques B; Kroemer G
New EMBO members' review: viral and bacterial proteins regulating apoptosis at the mitochondrial level.
The EMBO journal 2001;20(16):4325-31.
2001: Bombarda E; Morellet N; Cherradi H; Spiess B; Bouaziz S; Grell E; Roques B P; Mély Y
Determination of the pK(a) of the four Zn2+-coordinating residues of the distal finger motif of the HIV-1 nucleocapsid protein: consequences on the binding of Zn2+.
Journal of molecular biology 2001;310(3):659-72.
2001: Daugé V; Beslot F; Matsui T; Roques B P
Mutant mice lacking the cholecystokinin2 receptor show a dopamine-dependent hyperactivity and a behavioral sensitization to morphine.
Neuroscience letters 2001;306(1-2):41-4.
2001: Luciani N; de Rocquigny H; Turcaud S; Romieu A; Roques B P
Highly sensitive and selective fluorescence assays for rapid screening of endothelin-converting enzyme inhibitors.
The Biochemical journal 2001;356(Pt 3):813-9.
2001: Valverde O; Noble F; Beslot F; Daugé V; Fournié-Zaluski M C; Roques B P
Delta9-tetrahydrocannabinol releases and facilitates the effects of endogenous enkephalins: reduction in morphine withdrawal syndrome without change in rewarding effect.
The European journal of neuroscience 2001;13(9):1816-24.
2001: Anne C; Cornille F; Lenoir C; Roques B P
High-throughput fluorogenic assay for determination of botulinum type B neurotoxin protease activity.
Analytical biochemistry 2001;291(2):253-61.
2001: Mas-Nieto M; Pommier B; Tzavara E T; Caneparo A; Da Nascimento S; Le Fur G; Roques B P; Noble F
Reduction of opioid dependence by the CB(1) antagonist SR141716A in mice: evaluation of the interest in pharmacotherapy of opioid addiction.
British journal of pharmacology 2001;132(8):1809-16.
2001: Jacotot E; Ferri K F; El Hamel C; Brenner C; Druillennec S; Hoebeke J; Rustin P; Métivier D; Lenoir C; Geuskens M; Vieira H L; Loeffler M; Belzacq A S; Briand J P; Zamzami N; Edelman L; Xie Z H; Reed J C; Roques B P; Kroemer G
Control of mitochondrial membrane permeabilization by adenine nucleotide translocator interacting with HIV-1 viral protein rR and Bcl-2.
The Journal of experimental medicine 2001;193(4):509-19.
2001: Tisné C; Roques B P; Dardel F
Heteronuclear NMR studies of the interaction of tRNA(Lys)3 with HIV-1 nucleocapsid protein.
Journal of molecular biology 2001;306(3):443-54.
2001: Boudinot E; Morin-Surun M; Foutz A S; Fournié-Zaluski M; Roques B P; Denavit-Saubié M
Effects of the potent analgesic enkephalin-catabolizing enzyme inhibitors RB101 and kelatorphan on respiration.
Pain 2001;90(1-2):7-13.
2001: Noble F; Banisadr G; Jardinaud F; Popovici T; Lai-Kuen R; Chen H; Bischoff L; Parsadaniantz S M; Fournie-Zaluski M C; Roques B P
First discrete autoradiographic distribution of aminopeptidase N in various structures of rat brain and spinal cord using the selective iodinated inhibitor [125I]RB 129.
Neuroscience 2001;105(2):479-88.
2000: Roques B P
Novel approaches to targeting neuropeptide systems.
Trends in pharmacological sciences 2000;21(12):475-83.
2000: Garbay C; Liu W Q; Vidal M; Roques B P
Inhibitors of Ras signal transduction as antitumor agents.
Biochemical pharmacology 2000;60(8):1165-9.
2000: Roques B P; Anne C; Turcaud S; Fournié-Zaluski M C
Mechanism of action of clostridial neurotoxins and rational inhibitor design.
Biology of the cell / under the auspices of the European Cell Biology Organization 2000;92(6):445-7.
2000: De Rocquigny H; Caneparo A; Dong C Z; Delaunay T; Roques B P
Generation of monoclonal antibodies specifically directed against the proximal zinc finger of HIV type 1 NCp7.
AIDS research and human retroviruses 2000;16(13):1259-67.
2000: Bousquet J A; Garbay C; Roques B P; Mély Y
Circular dichroic investigation of the native and non-native conformational states of the growth factor receptor-binding protein 2 N-terminal src homology domain 3: effect of binding to a proline-rich peptide from guanine nucleotide exchange factor.
Biochemistry 2000;39(26):7722-35.
2000: Noble F; Szücs M; Kieffer B; Roques B P
Overexpression of dynamin is induced by chronic stimulation of mu- but not delta-opioid receptors: relationships with mu-related morphine dependence.
Molecular pharmacology 2000;58(1):159-66.
2000: de Rocquigny H; Caneparo A; Delaunay T; Bischerour J; Mouscadet J F; Roques B P
Interactions of the C-terminus of viral protein R with nucleic acids are modulated by its N-terminus.
European journal of biochemistry / FEBS 2000;267(12):3654-60.
2000: Kichler A; Pages J C; Leborgne C; Druillennec S; Lenoir C; Coulaud D; Delain E; Le Cam E; Roques B P; Danos O
Efficient DNA transfection mediated by the C-terminal domain of human immunodeficiency virus type 1 viral protein R.
Journal of virology 2000;74(12):5424-31.
2000: Marie-Claire C; Tiraboschi G; Ruffet E; Inguimbert N; Fournie-Zaluski M C; Roques B P
Exploration of the S(')(1) subsite of neprilysin: a joined molecular modeling and site-directed mutagenesis study.
Proteins 2000;39(4):365-71.
2000: Chen H; Noble F; Mothé A; Meudal H; Coric P; Danascimento S; Roques B P; George P; Fournié-Zaluski M C
Phosphinic derivatives as new dual enkephalin-degrading enzyme inhibitors: synthesis, biological properties, and antinociceptive activities.
Journal of medicinal chemistry 2000;43(7):1398-408.
2000: Hsu M; Rong L; de Rocquigny H; Roques B P; Wainberg M A
The effect of mutations in the HIV-1 nucleocapsid protein on strand transfer in cell-free reverse transcription reactions.
Nucleic acids research 2000;28(8):1724-9.
2000: Valverde O; Ledent C; Beslot F; Parmentier M; Roques B P
Reduction of stress-induced analgesia but not of exogenous opioid effects in mice lacking CB1 receptors.
The European journal of neuroscience 2000;12(2):533-9.
2000: Gajiwala K S; Chen H; Cornille F; Roques B P; Reith W; Mach B; Burley S K
Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding.
Nature 2000;403(6772):916-21.
2000: Noble F; Luciani N; Da Nascimento S; Laï-Kuen R; Bischoff L; Chen H; Fournié-Zaluski M C; Roques B P
Binding properties of a highly potent and selective iodinated aminopeptidase N inhibitor appropriate for radioautography.
FEBS letters 2000;467(1):81-6.
2000: Jacotot E; Ravagnan L; Loeffler M; Ferri K F; Vieira H L; Zamzami N; Costantini P; Druillennec S; Hoebeke J; Briand J P; Irinopoulou T; Daugas E; Susin S A; Cointe D; Xie Z H; Reed J C; Roques B P; Kroemer G
The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore.
The Journal of experimental medicine 2000;191(1):33-46.
2000: Reaux A; Iturrioz X; Vazeux G; Fournie-Zaluski M C; David C; Roques B P; Corvol P; Llorens-Cortes C
Aminopeptidase A, which generates one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, has a key role in central control of arterial blood pressure.
Biochemical Society transactions 2000;28(4):435-40.
1999: Vuilleumier C; Bombarda E; Morellet N; Gérard D; Roques B P; Mély Y
Nucleic acid sequence discrimination by the HIV-1 nucleocapsid protein NCp7: a fluorescence study.
Biochemistry 1999;38(51):16816-25.
1999: David C; Bischoff L; Meudal H; Mothé A; De Mota N; DaNascimento S; Llorens-Cortes C; Fournié-Zaluski M C; Roques B P
Investigation of subsite preferences in aminopeptidase A (EC 3.4.11.7) led to the design of the first highly potent and selective inhibitors of this enzyme.
Journal of medicinal chemistry 1999;42(25):5197-211.
1999: Noble F; Wank S A; Crawley J N; Bradwejn J; Seroogy K B; Hamon M; Roques B P
International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin receptors.
Pharmacological reviews 1999;51(4):745-81.
1999: Cornille F; Wecker K; Loffet A; Genet R; Roques B
Efficient solid-phase synthesis of Vpr from HIV-1 using low quantities of uniformly 13C-, 15N-labeled amino acids for NMR structural studies.
The journal of peptide research : official journal of the American Peptide Society 1999;54(5):427-35.
1999: Reaux A; Fournie-Zaluski M C; David C; Zini S; Roques B P; Corvol P; Llorens-Cortes C
Aminopeptidase A inhibitors as potential central antihypertensive agents.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(23):13415-20.
1999: Hutcheson D M; Sánchez-Blazquez P; Rodriguez-Diaz M; Garzon J; Schmidhammer H; Borsodi A; Roques B P; Maldonado R
Use of selective antagonists and antisense oligonucleotides to evaluate the mechanisms of BUBU antinociception.
European journal of pharmacology 1999;383(1):29-37.
1999: Schüler W; Dong C; Wecker K; Roques B P
NMR structure of the complex between the zinc finger protein NCp10 of Moloney murine leukemia virus and the single-stranded pentanucleotide d(ACGCC): comparison with HIV-NCp7 complexes.
Biochemistry 1999;38(40):12984-94.
1999: Gaucher J F; Selkti M; Tiraboschi G; Prangé T; Roques B P; Tomas A; Fournié-Zaluski M C
Crystal structures of alpha-mercaptoacyldipeptides in the thermolysin active site: structural parameters for a Zn monodentation or bidentation in metalloendopeptidases.
Biochemistry 1999;38(39):12569-76.
1999: Liu W Q; Vidal M; Gresh N; Roques B P; Garbay C
Small peptides containing phosphotyrosine and adjacent alphaMe-phosphotyrosine or its mimetics as highly potent inhibitors of Grb2 SH2 domain.
Journal of medicinal chemistry 1999;42(18):3737-41.
1999: Hus-Citharel A; Gasc J M; Zini S; Marchetti J; Roques B; Corvol P; Llorens-Cortes C
Aminopeptidase A activity and angiotensin III effects on [Ca2+]i along the rat nephron.
Kidney international 1999;56(3):850-9.
1999: Sebret A; Léna I; Crété D; Matsui T; Roques B P; Daugé V
Rat hippocampal neurons are critically involved in physiological improvement of memory processes induced by cholecystokinin-B receptor stimulation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(16):7230-7.
1999: Daugé V; Samir A; Cupo A; Roques B P
Peripheral stimulation of CCK-B receptors by BC264 induces a hyperexploration, dependent on the delta opioid system in the nucleus accumbens of rat.
Neuropharmacology 1999;38(7):999-1007.
1999: Ramboarina S; Morellet N; Fournié-Zaluski M C; Roques B P;
Structural investigation on the requirement of CCHH zinc finger type in nucleocapsid protein of human immunodeficiency virus 1.
Biochemistry 1999;38(30):9600-7.
1999: Le Guen S; Honoré P; Catheline G; Fournié-Zaluski M C; Roques B P; Besson J M
The effects of RB101, a mixed inhibitor of enkephalin-catabolizing enzymes, on carrageenin-induced spinal c-Fos expression are completely blocked by beta-funaltrexamine, a selective mu-opioid receptor antagonist.
Brain research 1999;834(1-2):200-6.
1999: Pommier B; Da Nascimento S; Dumont S; Bellier B; Million E; Garbay C; Roques B P; Noble F
The cholecystokininB receptor is coupled to two effector pathways through pertussis toxin-sensitive and -insensitive G proteins.
Journal of neurochemistry 1999;73(1):281-8.
1999: Noble F; Roques B P
CCK-B receptor: chemistry, molecular biology, biochemistry and pharmacology.
Progress in neurobiology 1999;58(4):349-79.
1999: Chen H; Roques B P; Fournié-Zaluski M C
Design of the first highly potent and selective aminopeptidase N (EC 3.4.11.2) inhibitor.
Bioorganic & medicinal chemistry letters 1999;9(11):1511-6.
1999: Réaux A; de Mota N; Zini S; Cadel S; Fournié-Zaluski M C; Roques B P; Corvol P; Llorens-Cortès C
PC18, a specific aminopeptidase N inhibitor, induces vasopressin release by increasing the half-life of brain angiotensin III.
Neuroendocrinology 1999;69(5):370-6.
1999: Taghzouti K; Léna I; Dellu F; Roques B P; Daugé V; Simon H
Cognitive enhancing effects in young and old rats of pBC264, a selective CCK(B) receptor agonist.
Psychopharmacology 1999;143(2):141-9.
1999: Léna I; Simon H; Roques B P; Daugé V
Opposing effects of two CCK(B) agonists on the retrieval phase of a two-trial memory task after systemic injection in the rat.
Neuropharmacology 1999;38(4):543-53.
1999: Druillennec S; Dong C Z; Escaich S; Gresh N; Bousseau A; Roques B P; Fournié-Zaluski M C
A mimic of HIV-1 nucleocapsid protein impairs reverse transcription and displays antiviral activity.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(9):4886-91.
1999: Druillennec S; Caneparo A; de Rocquigny H; Roques B P
Evidence of interactions between the nucleocapsid protein NCp7 and the reverse transcriptase of HIV-1.
The Journal of biological chemistry 1999;274(16):11283-8.
1999: Bombarda E; Ababou A; Vuilleumier C; Gérard D; Roques B P; Piémont E; Mély Y
Time-resolved fluorescence investigation of the human immunodeficiency virus type 1 nucleocapsid protein: influence of the binding of nucleic acids.
Biophysical journal 1999;76(3):1561-70.
1999: Tiraboschi G; Jullian N; Thery V; Antonczak S; Fournie-Zaluski M C; Roques B P
A three-dimensional construction of the active site (region 507-749) of human neutral endopeptidase (EC.3.4.24.11).
Protein engineering 1999;12(2):141-9.
1999: Druillennec S; Meudal H; Roques B P; Fournié-Zaluski M C
Nucleomimetic strategy for the inhibition of HIV-1 nucleocapsid protein NCp7 activities.
Bioorganic & medicinal chemistry letters 1999;9(4):627-32.
1999: Martin L; Cornille F; Turcaud S; Meudal H; Roques B P; Fournié-Zaluski M C
Metallopeptidase inhibitors of tetanus toxin: A combinatorial approach.
Journal of medicinal chemistry 1999;42(3):515-25.
1999: Schüler W; Wecker K; de Rocquigny H; Baudat Y; Sire J; Roques B P
NMR structure of the (52-96) C-terminal domain of the HIV-1 regulatory protein Vpr: molecular insights into its biological functions.
Journal of molecular biology 1999;285(5):2105-17.
1999: Marie-Claire C; Ruffet E; Beaumont A; Roques B P
The prosequence of thermolysin acts as an intramolecular chaperone when expressed in trans with the mature sequence in Escherichia coli.
Journal of molecular biology 1999;285(5):1911-5.
1999: Noble F; Fournié-Zaluski M C; Roques B P
[Enkephalin catabolism inhibitors and antalgics of the future: from preclinical research to clinical trials]
Thérapie 1999;54(1):121-33.
1999: Khelifa N; Brik M; Tessedre A C; De Rocquigny H; Roques B P; Courtieu J; Rimbault A
Cleavage of L-leucine-containing dipeptides by Clostridium butyricum.
Bioorganic & medicinal chemistry letters 1999;9(1):109-12.
1999: Ledent C; Valverde O; Cossu G; Petitet F; Aubert J F; Beslot F; Böhme G A; Imperato A; Pedrazzini T; Roques B P; Vassart G; Fratta W; Parmentier M
Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice.
Science (New York, N.Y.) 1999;283(5400):401-4.
1999: Cussac D; Vidal M; Leprince C; Liu W Q; Cornille F; Tiraboschi G; Roques B P; Garbay C
A Sos-derived peptidimer blocks the Ras signaling pathway by binding both Grb2 SH3 domains and displays antiproliferative activity.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(1):31-8.
1998: Hutcheson D M; Tzavara E T; Smadja C; Valjent E; Roques B P; Hanoune J; Maldonado R
Behavioural and biochemical evidence for signs of abstinence in mice chronically treated with delta-9-tetrahydrocannabinol.
British journal of pharmacology 1998;125(7):1567-77.
1998: Lener D; Tanchou V; Roques B P; Le Grice S F; Darlix J L
Involvement of HIV-I nucleocapsid protein in the recruitment of reverse transcriptase into nucleoprotein complexes formed in vitro.
The Journal of biological chemistry 1998;273(50):33781-6.
1998: Rong L; Liang C; Hsu M; Kleiman L; Petitjean P; de Rocquigny H; Roques B P; Wainberg M A
Roles of the human immunodeficiency virus type 1 nucleocapsid protein in annealing and initiation versus elongation in reverse transcription of viral negative-strand strong-stop DNA.
Journal of virology 1998;72(11):9353-8.
1998: Morellet N; Déméné H; Teilleux V; Huynh-Dinh T; de Rocquigny H; Fournié-Zaluski M C; Roques B P
Structure of the complex between the HIV-1 nucleocapsid protein NCp7 and the single-stranded pentanucleotide d(ACGCC).
Journal of molecular biology 1998;283(2):419-34.
1998: Ramboarina S; Morellet N; Petitjean P; Roques B P; Fournié-Zaluski M C
Model of the complex formed between the H2 domain of the TATA box binding protein and the L(281-301) fragment of the human transcription factor TFIIA.
Protein engineering 1998;11(9):729-38.
1998: Ortega-Alvaro A; Chover-Gonzalez A J; Lai-Kuen R; Mico J A; Gibert-Rahola J; Fournié-Zaluski M C; Roques B P; Maldonado R
Antinociception produced by the peptidase inhibitor, RB 101, in rats with adrenal medullary transplant into the spinal cord.
European journal of pharmacology 1998;356(2-3):139-48.
1998: Chen H; Noble F; Coric P; Fournie-Zaluski M C; Roques B P
Aminophosphinic inhibitors as transition state analogues of enkephalin-degrading enzymes: a class of central analgesics.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):12028-33.
1998: Matthes H W; Smadja C; Valverde O; Vonesch J L; Foutz A S; Boudinot E; Denavit-Saubié M; Severini C; Negri L; Roques B P; Maldonado R; Kieffer B L
Activity of the delta-opioid receptor is partially reduced, whereas activity of the kappa-receptor is maintained in mice lacking the mu-receptor.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(18):7285-95.
1998: Martin L; Cornille F; Coric P; Roques B P; Fournié-Zaluski M C
Beta-amino-thiols inhibit the zinc metallopeptidase activity of tetanus toxin light chain.
Journal of medicinal chemistry 1998;41(18):3450-60.
1998: Ladurelle N; Sebret A; Garbay C; Roques B P; Daugé V
Opposite effects of CCK(B) agonists in grooming behaviour in rats: further evidence for two CCK(B) subsites.
British journal of pharmacology 1998;124(6):1091-8.
1998: Bellier B; Da Nascimento S; Meudal H; Gincel E; Roques B P; Garbay C
Novel constrained CCK-B dipeptoid antagonists derived from pipecolic acid.
Bioorganic & medicinal chemistry letters 1998;8(11):1419-24.
1998: Jagerschmidt A; Guillaume N; Roques B P; Noble F
Binding sites and transduction process of the cholecystokininB receptor: involvement of highly conserved aromatic residues of the transmembrane domains evidenced by site-directed mutagenesis.
Molecular pharmacology 1998;53(5):878-85.
1998: Cornille F; Emery P; Schüler W; Lenoir C; Mach B; Roques B P; Reith W
DNA binding properties of a chemically synthesized DNA binding domain of hRFX1.
Nucleic acids research 1998;26(9):2143-9.
1998: Valverde O; Roques B P
Cholecystokinin modulates the aversive component of morphine withdrawal syndrome in rats.
Neuroscience letters 1998;244(1):37-40.
1998: Allain B; Rascle J B; de Rocquigny H; Roques B; Darlix J L
CIS elements and trans-acting factors required for minus strand DNA transfer during reverse transcription of the genomic RNA of murine leukemia virus.
Journal of molecular biology 1998;277(2):225-35.
1998: Marie-Claire C; Roques B P; Beaumont A
Intramolecular processing of prothermolysin.
The Journal of biological chemistry 1998;273(10):5697-701.
1998: Le Cam E; Coulaud D; Delain E; Petitjean P; Roques B P; Gérard D; Stoylova E; Vuilleumier C; Stoylov S P; Mély Y
Properties and growth mechanism of the ordered aggregation of a model RNA by the HIV-1 nucleocapsid protein: an electron microscopy investigation.
Biopolymers 1998;45(3):217-29.
1998: Vidal M; Montiel J L; Cussac D; Cornille F; Duchesne M; Parker F; Tocqué B; Roques B P; Garbay C
Differential interactions of the growth factor receptor-bound protein 2 N-SH3 domain with son of sevenless and dynamin. Potential role in the Ras-dependent signaling pathway.
The Journal of biological chemistry 1998;273(9):5343-8.
1998: Remy E; de Rocquigny H; Petitjean P; Muriaux D; Theilleux V; Paoletti J; Roques B P
The annealing of tRNA3Lys to human immunodeficiency virus type 1 primer binding site is critically dependent on the NCp7 zinc fingers structure.
The Journal of biological chemistry 1998;273(9):4819-22.
1998: Simonin F; Valverde O; Smadja C; Slowe S; Kitchen I; Dierich A; Le Meur M; Roques B P; Maldonado R; Kieffer B L
Disruption of the kappa-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa-agonist U-50,488H and attenuates morphine withdrawal.
The EMBO journal 1998;17(4):886-97.
1998: Luciani N; Marie-Claire C; Ruffet E; Beaumont A; Roques B P; Fournié-Zaluski M C
Characterization of Glu350 as a critical residue involved in the N-terminal amine binding site of aminopeptidase N (EC 3.4.11.2): insights into its mechanism of action.
Biochemistry 1998;37(2):686-92.
1997: Noble F; Smadja C; Valverde O; Maldonado R; Coric P; Turcaud S; Fournié-Zaluski M C; Roques B P
Pain-suppressive effects on various nociceptive stimuli (thermal, chemical, electrical and inflammatory) of the first orally active enkephalin-metabolizing enzyme inhibitor RB 120.
Pain 1997;73(3):383-91.
1997: de Rocquigny H; Petitjean P; Tanchou V; Decimo D; Drouot L; Delaunay T; Darlix J L; Roques B P
The zinc fingers of HIV nucleocapsid protein NCp7 direct interactions with the viral regulatory protein Vpr.
The Journal of biological chemistry 1997;272(49):30753-9.
1997: Roques B P; Morellet N; de Rocquigny H; Déméné H; Schueler W; Jullian N
Structure, biological functions and inhibition of the HIV-1 proteins Vpr and NCp7.
Biochimie 1997;79(11):673-80.
1997: Bellier B; McCort-Tranchepain I; Ducos B; Danascimento S; Meudal H; Noble F; Garbay C; Roques B P
Synthesis and biological properties of new constrained CCK-B antagonists: discrimination of two affinity states of the CCK-B receptor on transfected CHO cells.
Journal of medicinal chemistry 1997;40(24):3947-56.
1997: Marie-Claire C; Ruffet E; Antonczak S; Beaumont A; O'Donohue M; Roques B P; Fournié-Zaluski M C
Evidence by site-directed mutagenesis that arginine 203 of thermolysin and arginine 717 of neprilysin (neutral endopeptidase) play equivalent critical roles in substrate hydrolysis and inhibitor binding.
Biochemistry 1997;36(45):13938-45.
1997: Dong C Z; De Rocquigny H; Rémy E; Mellac S; Fournié-Zaluski M C; Roques B P
Synthesis and biological activities of fluorescent acridine-containing HIV-1 nucleocapsid proteins for investigation of nucleic acid-NCp7 interactions.
The journal of peptide research : official journal of the American Peptide Society 1997;50(4):269-78.
1997: Ladurelle N; Keller G; Blommaert A; Roques B P; Daugé V
The CCK-B agonist, BC264, increases dopamine in the nucleus accumbens and facilitates motivation and attention after intraperitoneal injection in rats.
The European journal of neuroscience 1997;9(9):1804-14.
1997: Bertrand E; Smadja C; Mauborgne A; Roques B P; Daugé V
Social interaction increases the extracellular levels of [Met]enkephalin in the nucleus accumbens of control but not of chronic mild stressed rats.
Neuroscience 1997;80(1):17-20.
1997: Smadja C; Ruiz F; Coric P; Fournié-Zaluski M C; Roques B P; Maldonado R
CCK-B receptors in the limbic system modulate the antidepressant-like effects induced by endogenous enkephalins.
Psychopharmacology 1997;132(3):227-36.
1997: Maldonado R; Saiardi A; Valverde O; Samad T A; Roques B P; Borrelli E
Absence of opiate rewarding effects in mice lacking dopamine D2 receptors.
Nature 1997;388(6642):586-9.
1997: Carteau S; Batson S C; Poljak L; Mouscadet J F; de Rocquigny H; Darlix J L; Roques B P; Käs E; Auclair C
Human immunodeficiency virus type 1 nucleocapsid protein specifically stimulates Mg2+-dependent DNA integration in vitro.
Journal of virology 1997;71(8):6225-9.
1997: Zini S; Masdehors P; Lenkei Z; Fournie-Zaluski M C; Roques B P; Corvol P; Llorens-Cortes C
Aminopeptidase A: distribution in rat brain nuclei and increased activity in spontaneously hypertensive rats.
Neuroscience 1997;78(4):1187-93.
1997: Valverde O; Smadja C; Roques B P; Maldonado R
The attenuation of morphine-conditioned place preference following chronic mild stress is reversed by a CCKB receptor antagonist.
Psychopharmacology 1997;131(1):79-85.
1997: Honore P; Buritova J; Fournié-Zaluski M C; Roques B P; Besson J M
Antinociceptive effects of RB101, a complete inhibitor of enkephalin-catabolizing enzymes, are enhanced by a cholecystokinin type B receptor antagonist, as revealed by noxiously evoked spinal c-Fos expression in rats.
The Journal of pharmacology and experimental therapeutics 1997;281(1):208-17.
1997: Stoylov S P; Vuilleumier C; Stoylova E; De Rocquigny H; Roques B P; Gérard D; Mély Y
Ordered aggregation of ribonucleic acids by the human immunodeficiency virus type 1 nucleocapsid protein.
Biopolymers 1997;41(3):301-12.
1997: Blommaert A G; Dhôtel H; Ducos B; Durieux C; Goudreau N; Bado A; Garbay C; Roques B P
Structure-based design of new constrained cyclic agonists of the cholecystokinin CCK-B receptor.
Journal of medicinal chemistry 1997;40(5):647-58.
1997: Cornille F; Martin L; Lenoir C; Cussac D; Roques B P; Fournie-Zaluski M C
Cooperative exosite-dependent cleavage of synaptobrevin by tetanus toxin light chain.
The Journal of biological chemistry 1997;272(6):3459-64.
1997: Noble F; Roques B P
Association of aminopeptidase N and endopeptidase 24.15 inhibitors potentiate behavioral effects mediated by nociceptin/orphanin FQ in mice.
FEBS letters 1997;401(2-3):227-9.
1997: Montiel J L; Cornille F; Roques B P; Noble F
Nociceptin/orphanin FQ metabolism: role of aminopeptidase and endopeptidase 24.15.
Journal of neurochemistry 1997;68(1):354-61.
1997: Léna I; Roques B P; Durieux C
Dual modulation of dopamine release from anterior nucleus accumbens through cholecystokinin-B receptor subsites.
Journal of neurochemistry 1997;68(1):162-8.
1996: Valverde O; Tzavara E; Hanoune J; Roques B P; Maldonado R
Protein kinases in the rat nucleus accumbens are involved in the aversive component of opiate withdrawal.
The European journal of neuroscience 1996;8(12):2671-8.
1996: Muriaux D; De Rocquigny H; Roques B P; Paoletti J
NCp7 activates HIV-1Lai RNA dimerization by converting a transient loop-loop complex into a stable dimer.
The Journal of biological chemistry 1996;271(52):33686-92.
1996: Noble F; Fournie-Zaluski M C; Roques B P
Opposite role of delta 1- and delta 2-opioid receptors activated by endogenous or exogenous opioid agonists on the endogenous cholecystokinin system: further evidence for delta-opioid receptor heterogeneity.
Neuroscience 1996;75(3):917-26.
1996: Blanco-Príeto M J; Durieux C; Daugé V; Fattal E; Couvreur P; Roques B P
Slow delivery of the selective cholecystokinin agonist pBC 264 into the rat nucleus accumbens using microspheres.
Journal of neurochemistry 1996;67(6):2417-24.
1996: Soleilhac J M; Lafuma C; Porcher J M; Auburtin G; Roques B P
Characterization of a soluble form of neutral endopeptidase-24.11 (EC 3.4.24.11) in human serum: enhancement of its activity in serum of underground miners exposed to coal dust particles.
European journal of clinical investigation 1996;26(11):1011-7.
1996: Roques B P; Noble F
Association of enkephalin catabolism inhibitors and CCK-B antagonists: a potential use in the management of pain and opioid addiction.
Neurochemical research 1996;21(11):1397-410.
1996: Soleilhac J M; Cornille F; Martin L; Lenoir C; Fournié-Zaluski M C; Roques B P
A sensitive and rapid fluorescence-based assay for determination of tetanus toxin peptidase activity.
Analytical biochemistry 1996;241(1):120-7.
1996: Matthes H W; Maldonado R; Simonin F; Valverde O; Slowe S; Kitchen I; Befort K; Dierich A; Le Meur M; Dollé P; Tzavara E; Hanoune J; Roques B P; Kieffer B L
Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene.
Nature 1996;383(6603):819-23.
1996: Zini S; Fournie-Zaluski M C; Chauvel E; Roques B P; Corvol P; Llorens-Cortes C
Identification of metabolic pathways of brain angiotensin II and III using specific aminopeptidase inhibitors: predominant role of angiotensin III in the control of vasopressin release.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(21):11968-73.
1996: Valverde O; Fournié-Zaluski M C; Roques B P; Maldonado R
Similar involvement of several brain areas in the antinociception of endogenous and exogenous opioids.
European journal of pharmacology 1996;312(1):15-25.
1996: Ruiz F; Fournié-Zaluski M C; Roques B P; Maldonado R
Similar decrease in spontaneous morphine abstinence by methadone and RB 101, an inhibitor of enkephalin catabolism.
British journal of pharmacology 1996;119(1):174-82.
1996: Daugé V; Mauborgne A; Cesselin F; Fournié-Zaluski M C; Roques B P
The dual peptidase inhibitor RB101 induces a long-lasting increase in the extracellular level of Met-enkephalin-like material in the nucleus accumbens of freely moving rats.
Journal of neurochemistry 1996;67(3):1301-8.
1996: Weng J H; Bado A; Garbay C; Roques B P
Novel CCK-B receptor agonists: diketopiperazine analogues derived for CCK4 bioactive conformation.
Regulatory peptides 1996;65(1):3-9.
1996: Gonzalez W; Beslot F; Laboulandine I; Fournié-Zaluski M C; Roques B P; Michel J B
Inhibition of both angiotensin-converting enzyme and neutral endopeptidase by S21402 (RB105) in rats with experimental myocardial infarction.
The Journal of pharmacology and experimental therapeutics 1996;278(2):573-81.
1996: Li X; Quan Y; Arts E J; Li Z; Preston B D; de Rocquigny H; Roques B P; Darlix J L; Kleiman L; Parniak M A; Wainberg M A
Human immunodeficiency virus Type 1 nucleocapsid protein (NCp7) directs specific initiation of minus-strand DNA synthesis primed by human tRNA(Lys3) in vitro: studies of viral RNA molecules mutated in regions that flank the primer binding site.
Journal of virology 1996;70(8):4996-5004.
1996: Maldonado R; Blendy J A; Tzavara E; Gass P; Roques B P; Hanoune J; Schütz G
Reduction of morphine abstinence in mice with a mutation in the gene encoding CREB.
Science (New York, N.Y.) 1996;273(5275):657-9.
1996: Girard P M; de Rocquigny H; Roques B P; Paoletti J
A model of PSI dimerization: destabilization of the C278-G303 stem-loop by the nucleocapsid protein (NCp10) of MoMuLV.
Biochemistry 1996;35(26):8705-14.
1996: Fournie-Zaluski M C; Coric P; Thery V; Gonzalez W; Meudal H; Turcaud S; Michel J B; Roques B P
Design of orally active dual inhibitors of neutral endopeptidase and angiotensin-converting enzyme with long duration of action.
Journal of medicinal chemistry 1996;39(13):2594-608.
1996: Weng J H; Blommaert A G; Moizo L; Bado A; Ducos B; Böhme A; Garbay C; Roques B P
Role of N- and C-terminal substituents on the CCK-B agonist-antagonist pharmacological profile of Boc-Trp-Phg-Asp-Nal-NH2 derivatives.
Bioorganic & medicinal chemistry 1996;4(4):563-73.
1996: Goudreau N; Weng J H; Roques B P
Comparative conformational analysis of CCK-B agonist Boc-Trp-Phg-Asp-(1-Nal)-NH2 and CCK1-B antagonist Boc-Trp-Phg-Asp-(1-Nal)-N(Me)2 using 1HNMR spectroscopy and restrained molecular dynamics.
Archiv der Pharmazie 1996;329(4):197-204.
1996: Mély Y; De Rocquigny H; Morellet N; Roques B P; Gérad D
Zinc binding to the HIV-1 nucleocapsid protein: a thermodynamic investigation by fluorescence spectroscopy.
Biochemistry 1996;35(16):5175-82.
1996: Coric P; Turcaud S; Meudal H; Roques B P; Fournie-Zaluski M C
Optimal recognition of neutral endopeptidase and angiotensin-converting enzyme active sites by mercaptoacyldipeptides as a means to design potent dual inhibitors.
Journal of medicinal chemistry 1996;39(6):1210-9.
1996: Million M E; Mailliett P; Chen H; Bashiardes G; Boiziau J; Parker F; Commerçon A; Tocque B; Roques B P; Garbay C
Synthesis and biological evaluation of a new series of phenylhydroquinone derivatives as inhibitors of EGF-R-associated PTK activity.
Anti-cancer drug design 1996;11(2):129-53.
1996: Pham I; Gonzalez W; Doucet J; Fournie-Zaluski M C; Roques B P; Michel J B
Effects of angiotensin-converting enzyme and neutral endopeptidase inhibitors: influence of bradykinin.
European journal of pharmacology 1996;296(3):267-76.
1996: Jagerschmidt A; Guillaume-Rousselet N; Vikland M L; Goudreau N; Maigret B; Roques B P
His381 of the rat CCKB receptor is essential for CCKB versus CCKA receptor antagonist selectivity.
European journal of pharmacology 1996;296(1):97-106.
1996: Chen H; Bashiardes G; Mailliet P; Commercon A; Sounigo F; Boiziau J; Parker F; Tocque B; Roques B P; Garbay C
Synthesis and biological evaluation of a series of hydroxybenzylphenylamine derivatives as inhibitors of EGF receptor-associated tyrosine kinase activity.
Anti-cancer drug design 1996;11(1):49-71.
1996: Migaud M; Durieux C; Viereck J; Soroca-Lucas E; Fournié-Zaluski M C; Roques B P
The in vivo metabolism of cholecystokinin (CCK-8) is essentially ensured by aminopeptidase A.
Peptides 1996;17(4):601-7.
1995: Peyroux J; Beslot F; Claperon N; Fournie-Zaluski M C; Roques B P
Effect of endopeptidase-24.11 inhibitors and C-ANP receptor ligand on responses evoked in arterioles of rat cremaster muscle by atrial natriuretic peptide.
British journal of pharmacology 1995;116(8):3117-24.
1995: Maldonado R; Valverde O; Garbay C; Roques B P
Protein kinases in the locus coeruleus and periaqueductal gray matter are involved in the expression of opiate withdrawal.
Naunyn-Schmiedeberg's archives of pharmacology 1995;352(5):565-75.
1995: Valverde O; Blommaert A G; Fournié-Zaluski M C; Roques B P; Maldonado R
Weak tolerance to the antinociceptive effect induced by the association of a peptidase inhibitor and a CCKB receptor antagonist.
European journal of pharmacology 1995;286(1):79-93.
1995: Jagerschmidt A; Guillaume N; Goudreau N; Maigret B; Roques B P
Mutation of Asp100 in the second transmembrane domain of the cholecystokinin B receptor increases antagonist binding and reduces signal transduction.
Molecular pharmacology 1995;48(5):783-9.
1995: Million M E; Boiziau J; Parker F; Tocque B; Roques B P; Garbay C
Inhibition of the EGF-stimulated cellular proliferation of ER 22 cells by hydroxybiphenyl derivatives.
Journal of medicinal chemistry 1995;38(23):4693-703.
1995: Tanchou V; Delaunay T; Bodéus M; Roques B; Darlix J L; Benarous R
Conformational changes between human immunodeficiency virus type 1 nucleocapsid protein NCp7 and its precursor NCp15 as detected by anti-NCp7 monoclonal antibodies.
The Journal of general virology 1995;76 ( Pt 10)():2457-66.
1995: Tejedor-Real P; Mico J A; Maldonado R; Roques B P; Gibert-Rahola J
Implication of endogenous opioid system in the learned helplessness model of depression.
Pharmacology, biochemistry, and behavior 1995;52(1):145-52.
1995: Smadja C; Maldonado R; Turcaud S; Fournie-Zaluski M C; Roques B P
Opposite role of CCKA and CCKB receptors in the modulation of endogenous enkephalin antidepressant-like effects.
Psychopharmacology 1995;120(4):400-8.
1995: Cornille F; Deloye F; Fournié-Zaluski M C; Roques B P; Poulain B
Inhibition of neurotransmitter release by synthetic proline-rich peptides shows that the N-terminal domain of vesicle-associated membrane protein/synaptobrevin is critical for neuro-exocytosis.
The Journal of biological chemistry 1995;270(28):16826-32.
1995: Beaumont A; O'Donohue M J; Paredes N; Rousselet N; Assicot M; Bohuon C; Fournié-Zaluski M C; Roques B P
The role of histidine 231 in thermolysin-like enzymes. A site-directed mutagenesis study.
The Journal of biological chemistry 1995;270(28):16803-8.
1995: Migaud M; Roques B P; Durieux C
Evidence for a high-affinity uptake system for cholecystokinin octapeptide (CCK8) in rat cortical synaptosomes.
The European journal of neuroscience 1995;7(5):1074-9.
1995: Ladurelle N; Roques B P; Daugé V
The transfer of rats from a familiar to a novel environment prolongs the increase of extracellular dopamine efflux induced by CCK8 in the posterior nucleus accumbens.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(4):3118-27.
1995: Maldonado R; Valverde O; Ducos B; Blommaert A G; Fournie-Zaluski M C; Roques B P
Inhibition of morphine withdrawal by the association of RB 101, an inhibitor of enkephalin catabolism, and the CCKB antagonist PD-134,308.
British journal of pharmacology 1995;114(5):1031-9.
1995: Noble F; Roques B P
Assessment of endogenous enkephalins efficacy in the hot plate test in mice: comparative study with morphine.
Neuroscience letters 1995;185(2):75-8.
1995: Dauge V; Corringer P J; Roques B P
CCKA, but not CCKB, agonists suppress the hyperlocomotion induced by endogenous enkephalins, protected from enzymatic degradation by systemic RB 101.
Pharmacology, biochemistry, and behavior 1995;50(2):133-9.
1995: Mély Y; de Rocquigny H; Sorinas-Jimeno M; Keith G; Roques B P; Marquet R; Gérard D
Binding of the HIV-1 nucleocapsid protein to the primer tRNA(3Lys), in vitro, is essentially not specific.
The Journal of biological chemistry 1995;270(4):1650-6.
1995: Gonzalez Vera W; Fournié-Zaluski M C; Pham I; Laboulandine I; Roques B P; Michel J B
Hypotensive and natriuretic effects of RB 105, a new dual inhibitor of angiotensin converting enzyme and neutral endopeptidase in hypertensive rats.
The Journal of pharmacology and experimental therapeutics 1995;272(1):343-51.
1995: Noble F; Blommaert A; Fournié-Zaluski M C; Roques B P
A selective CCKB receptor antagonist potentiates, mu-, but not delta-opioid receptor-mediated antinociception in the formalin test.
European journal of pharmacology 1995;273(1-2):145-51.
1995: Roques B P; Noble F
Dual inhibitors of enkephalin-degrading enzymes (neutral endopeptidase 24.11 and aminopeptidase N) as potential new medications in the management of pain and opioid addiction.
NIDA research monograph 1995;147():104-45.
1995: Roques B P; Noble F; Crine P; Fournié-Zaluski M C
Inhibitors of neprilysin: design, pharmacological and clinical applications.
Methods in enzymology 1995;248():263-83.
1995: Pham I; Lévy B; Fournié-Zaluski M C; Poitevin P; Roques B P; Michel J B
Acute hemodynamic effects of combined inhibition of neutral endopeptidase and angiotensin converting enzyme in spontaneously hypertensive rats.
Fundamental & clinical pharmacology 1995;9(2):153-60.
1994: Noble F; Smadja C; Roques B P
Role of endogenous cholecystokinin in the facilitation of mu-mediated antinociception by delta-opioid agonists.
The Journal of pharmacology and experimental therapeutics 1994;271(3):1127-34.
1994: Goudreau N; Cornille F; Duchesne M; Parker F; Tocqué B; Garbay C; Roques B P
NMR structure of the N-terminal SH3 domain of GRB2 and its complex with a proline-rich peptide from Sos.
Nature structural biology 1994;1(12):898-907.
1994: Milhiet P E; Giocondi M C; Crine P; Le Grimellec C; Roques B P; Garbay-Jaureguiberry C
Fate of a fluorescent inhibitor of endopeptidase-24.11 using enzyme-expressing MDCK cells. Modification of its cellular processing with a monoclonal antibody.
European journal of cell biology 1994;65(2):258-68.
1994: Derrien M; Daugé V; Blommaert A; Roques B P
The selective CCK-B agonist, BC 264, impairs socially reinforced memory in the three-panel runway test in rats.
Behavioural brain research 1994;65(2):139-46.
1994: Jagerschmidt A; Popovici T; O'Donohue M; Roques B P
Identification and characterization of various cholecystokinin B receptor mRNA forms in rat brain tissue and partial determination of the cholecystokinin B receptor gene structure.
Journal of neurochemistry 1994;63(4):1199-206.
1994: Mély Y; Jullian N; Morellet N; De Rocquigny H; Dong C Z; Piémont E; Roques B P; Gérard D
Spatial proximity of the HIV-1 nucleocapsid protein zinc fingers investigated by time-resolved fluorescence and fluorescence resonance energy transfer.
Biochemistry 1994;33(40):12085-91.
1994: Chauvel E N; Llorens-Cortès C; Coric P; Wilk S; Roques B P; Fournié-Zaluski M C
Differential inhibition of aminopeptidase A and aminopeptidase N by new beta-amino thiols.
Journal of medicinal chemistry 1994;37(18):2950-7.
1994: Derrien M; McCort-Tranchepain I; Ducos B; Roques B P; Durieux C
Heterogeneity of CCK-B receptors involved in animal models of anxiety.
Pharmacology, biochemistry, and behavior 1994;49(1):133-41.
1994: Ladurelle N; Durieux C; Roques B P; Daugé V
Different modifications of the dopamine metabolism in the core and shell parts of the nucleus accumbens following CCK-A receptor stimulation in the shell region.
Neuroscience letters 1994;178(1):5-10.
1994: Tanchou V; Delaunay T; De Rocquigny H; Bodeus M; Darlix J L; Roques B; Benarous R
Monoclonal antibody-mediated inhibition of RNA binding and annealing activities of HIV type 1 nucleocapsid protein.
AIDS research and human retroviruses 1994;10(8):983-93.
1994: Valverde O; Maldonado R; Fournie-Zaluski M C; Roques B P
Cholecystokinin B antagonists strongly potentiate antinociception mediated by endogenous enkephalins.
The Journal of pharmacology and experimental therapeutics 1994;270(1):77-88.
1994: Maldonado R; Valverde O; Turcaud S; Fournié-Zaluski M C; Roques B P
Antinociceptive response induced by mixed inhibitors of enkephalin catabolism in peripheral inflammation.
Pain 1994;58(1):77-83.
1994: Maldonado R; Valverde O; Derrien M; Tejedor-Real P; Roques B P
Effects induced by BC 264, a selective agonist of CCK-B receptors, on morphine-dependent rats.
Pharmacology, biochemistry, and behavior 1994;48(2):363-9.
1994: Gomez-Monterrey I; Beaumont A; Nemecek P; Roques B P; Fournie-Zaluski M C
New thiol inhibitors of neutral endopeptidase EC 3.4.24.11: synthesis and enzyme active-site recognition.
Journal of medicinal chemistry 1994;37(12):1865-73.
1994: O'Donohue M J; Roques B P; Beaumont A
Cloning and expression in Bacillus subtilis of the npr gene from Bacillus thermoproteolyticus Rokko coding for the thermostable metalloprotease thermolysin.
The Biochemical journal 1994;300 ( Pt 2)():599-603.
1994: Migaud M; Roques B P; Durieux C
Effects of cholecystokinin octapeptide and BC 264, a potent and selective CCK-B agonist on aspartate and glutamate release from rat hippocampal slices.
Neuropharmacology 1994;33(6):737-43.
1994: Cornille F; Goudreau N; Ficheux D; Niemann H; Roques B P
Solid-phase synthesis, conformational analysis and in vitro cleavage of synthetic human synaptobrevin II 1-93 by tetanus toxin L chain.
European journal of biochemistry / FEBS 1994;222(1):173-81.
1994: Goudreau N; Guis C; Soleilhac J M; Roques B P
Dns-Gly-(p-NO2)Phe-beta Ala, a specific fluorogenic substrate for neutral endopeptidase 24.11.
Analytical biochemistry 1994;219(1):87-95.
1994: Fournié-Zaluski M C; Gonzalez W; Turcaud S; Pham I; Roques B P; Michel J B
Dual inhibition of angiotensin-converting enzyme and neutral endopeptidase by the orally active inhibitor mixanpril: a potential therapeutic approach in hypertension.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(9):4072-6.
1994: Fournié-Zaluski M C; Coric P; Turcaud S; Rousselet N; Gonzalez W; Barbe B; Pham I; Jullian N; Michel J B; Roques B P
New dual inhibitors of neutral endopeptidase and angiotensin-converting enzyme: rational design, bioavailability, and pharmacological responses in experimental hypertension.
Journal of medicinal chemistry 1994;37(8):1070-83.
1994: Chauvel E N; Coric P; Llorens-Cortès C; Wilk S; Roques B P; Fournié-Zaluski M C
Investigation of the active site of aminopeptidase A using a series of new thiol-containing inhibitors.
Journal of medicinal chemistry 1994;37(9):1339-46.
1994: Noble F; Coric P; Turcaud S; Fournié-Zaluski M C; Roques B P
Assessment of physical dependence after continuous perfusion into the rat jugular vein of the mixed inhibitor of enkephalin-degrading enzymes, RB 101.
European journal of pharmacology 1994;253(3):283-7.
1994: Durieux C; Derrien M; Maldonado R; Valverde O; Blommaert A; Fournié-Zaluski M C; Roques B P
CCK-B antagonists exhibit antidepressant-like effects and potentiate endogenous enkephalin analgesia. Correlation with in vivo binding affinities and brain penetration.
Annals of the New York Academy of Sciences 1994;713():355-7.
1994: Chen H; Boiziau J; Parker F; Mailliet P; Commerçon A; Tocque B; Le Pecq J B; Roques B P; Garbay C
Structure-activity relationships in a series of 5-[(2,5-dihydroxybenzyl)amino]salicylate inhibitors of EGF-receptor-associated tyrosine kinase: importance of additional hydrophobic aromatic interactions.
Journal of medicinal chemistry 1994;37(6):845-59.
1994: Yang Y S; Garbay C; Duchesne M; Cornille F; Jullian N; Fromage N; Tocque B; Roques B P
Solution structure of GAP SH3 domain by 1H NMR and spatial arrangement of essential Ras signaling-involved sequence.
The EMBO journal 1994;13(6):1270-9.
1994: Derrien M; Durieux C; Roques B P
Antidepressant-like effects of CCKB antagonists in mice: antagonism by naltrindole.
British journal of pharmacology 1994;111(3):956-60.
1994: Déméné H; Jullian N; Morellet N; de Rocquigny H; Cornille F; Maigret B; Roques B P
Three-dimensional 1H NMR structure of the nucleocapsid protein NCp10 of Moloney murine leukemia virus.
Journal of biomolecular NMR 1994;4(2):153-70.
1994: Goudreau N; Weng J H; Roques B P
Conformational analysis of CCK-B agonists using 1H-NMR and restrained molecular dynamics: comparison of biologically active Boc-Trp-(N-Me) Nle-Asp-Phe-NH2 and inactive Boc-Trp-(N-Me)Phe-Asp-Phe-NH2.
Biopolymers 1994;34(2):155-69.
1994: Akopyan T N; Couedel Y; Orlowski M; Fournie-Zaluski M C; Roques B P
Proteolytic processing of farnesylated peptides: assay and partial purification from pig brain membranes of an endopeptidase which has the characteristics of E.C. 3.4.24.15.
Biochemical and biophysical research communications 1994;198(2):787-94.
1994: Morellet N; de Rocquigny H; Mély Y; Jullian N; Déméné H; Ottmann M; Gérard D; Darlix J L; Fournie-Zaluski M C; Roques B P
Conformational behaviour of the active and inactive forms of the nucleocapsid NCp7 of HIV-1 studied by 1H NMR.
Journal of molecular biology 1994;235(1):287-301.
1994: Noble F; Fournié-Zaluski M C; Roques B P
Paradoxical analgesia induced by low doses of naloxone is not potentiated by complete inhibition of enkephalin degradation.
Neuropharmacology 1994;33(1):135-40.
1993: Chen H; Boiziau J; Parker F; Maroun R; Tocque B; Roques B P; Garbay-Jaureguiberry C
Synthesis and structure-activity studies of a series of [(hydroxybenzyl)amino]salicylates as inhibitors of EGF receptor-associated tyrosine kinase activity.
Journal of medicinal chemistry 1993;36(25):4094-8.
1993: Ladurelle N; Keller G; Roques B P; Daugé V
Effects of CCK8 and of the CCKB-selective agonist BC264 on extracellular dopamine content in the anterior and posterior nucleus accumbens: a microdialysis study in freely moving rats.
Brain research 1993;628(1-2):254-62.
1993: Blommaert A G; Weng J H; Dorville A; McCort I; Ducos B; Durieux C; Roques B P
Cholecystokinin peptidomimetics as selective CCK-B antagonists: design, synthesis, and in vitro and in vivo biochemical properties.
Journal of medicinal chemistry 1993;36(20):2868-77.
1993: Mély Y; Piémont E; Sorinas-Jimeno M; de Rocquigny H; Jullian N; Morellet N; Roques B P; Gérard D
Structural and dynamic characterization of the aromatic amino acids of the human immunodeficiency virus type I nucleocapsid protein zinc fingers and their involvement in heterologous tRNA(Phe) binding: a steady-state and time-resolved fluorescence study.
Biophysical journal 1993;65(4):1513-22.
1993: Pasquini F; Jomary C; Garbay-Jaureguiberry C; Roques B P; Beaudet A
[125I]azido-DTLET as a tool for selective covalent labeling of delta-opioid receptors in rat brain sections.
European journal of pharmacology 1993;243(1):39-45.
1993: Derrien M; Noble F; Maldonado R; Roques B P
Cholecystokinin-A but not cholecystokinin-B receptor stimulation induces endogenous opioid-dependent antinociceptive effects in the hot plate test in mice.
Neuroscience letters 1993;160(2):193-6.
1993: Julian N; Demene H; Morellet N; Maigret B; Roques B P
Replacement of His23 by Cys in a zinc finger of HIV-1 NCp7 led to a change in 1H NMR-derived 3D structure and to a loss of biological activity.
FEBS letters 1993;331(1-2):43-8.
1993: Noble F; Derrien M; Roques B P
Modulation of opioid antinociception by CCK at the supraspinal level: evidence of regulatory mechanisms between CCK and enkephalin systems in the control of pain.
British journal of pharmacology 1993;109(4):1064-70.
1993: Roques B P
Zinc metallopeptidases: active site structure and design of selective and mixed inhibitors: new approaches in the search for analgesics and anti-hypertensives.
Biochemical Society transactions 1993;21 ( Pt 3)(3):678-85.
1993: Derrien M; Durieux C; Daugé V; Roques B P
Involvement of D2 dopaminergic receptors in the emotional and motivational responses induced by injection of CCK-8 in the posterior part of the rat nucleus accumbens.
Brain research 1993;617(2):181-8.
1993: Tejedor-Real P; Micó J A; Maldonado R; Roques B P; Gibert-Rahola J
Effect of mixed (RB 38A) and selective (RB 38B) inhibitors of enkephalin degrading enzymes on a model of depression in the rat.
Biological psychiatry 1993;34(1-2):100-7.
1993: Maldonado R; Derrien M; Noble F; Roques B P
Association of the peptidase inhibitor RB 101 and a CCK-B antagonist strongly enhances antinociceptive responses.
Neuroreport 1993;4(7):947-50.
1993: Guis C; Bruetschy L; Meudal H; Roques B P; Gacel G A
Investigation of the structural parameters involved in the delta-opioid selectivity of several families of opioid peptides.
International journal of peptide and protein research 1993;41(6):576-86.
1993: Pham I; Gonzalez W; el Amrani A I; Fournié-Zaluski M C; Philippe M; Laboulandine I; Roques B P; Michel J B
Effects of converting enzyme inhibitor and neutral endopeptidase inhibitor on blood pressure and renal function in experimental hypertension.
The Journal of pharmacology and experimental therapeutics 1993;265(3):1339-47.
1993: Maldonado R; Girdlestone D; Roques B P
RP 67580, a selective antagonist of neurokinin-1 receptors, modifies some of the naloxone-precipitated morphine withdrawal signs in rats.
Neuroscience letters 1993;156(1-2):135-40.
1993: De Rocquigny H; Ficheux D; Gabus C; Allain B; Fournie-Zaluski M C; Darlix J L; Roques B P
Two short basic sequences surrounding the zinc finger of nucleocapsid protein NCp10 of Moloney murine leukemia virus are critical for RNA annealing activity.
Nucleic acids research 1993;21(4):823-9.
1993: Noble F; Fournié-Zaluski M C; Roques B P
Unlike morphine the endogenous enkephalins protected by RB101 are unable to establish a conditioned place preference in mice.
European journal of pharmacology 1993;230(2):139-49.
1993: Mely Y; de Rocquigny H; Piémont E; Déméné H; Jullian N; Fournié-Zaluski M C; Roques B; Gérard D
Influence of the N- and C-terminal chains on the zinc-binding and conformational properties of the central zinc-finger structure of Moloney murine leukaemia virus nucleocapsid protein: a steady-state and time-resolved fluorescence study.
Biochimica et biophysica acta 1993;1161(1):6-18.
1993: Gomez-Monterrey I; Turcaud S; Lucas E; Bruetschy L; Roques B P; Fournié-Zaluski M C
Exploration of neutral endopeptidase active site by a series of new thiol-containing inhibitors.
Journal of medicinal chemistry 1993;36(1):87-94.
1993: Corringer P J; Weng J H; Ducos B; Durieux C; Boudeau P; Bohme A; Roques B P
CCK-B agonist or antagonist activities of structurally hindered and peptidase-resistant Boc-CCK4 derivatives.
Journal of medicinal chemistry 1993;36(1):166-72.
1992: Pasquini F; Bochet P; Garbay-Jaureguiberry C; Roques B P; Rossier J; Beaudet A
Electron microscopic localization of photoaffinity-labelled delta opioid receptors in the neostriatum of the rat.
The Journal of comparative neurology 1992;326(2):229-44.
1992: Daugé V; Kalivas P W; Duffy T; Roques B P
Effect of inhibiting enkephalin catabolism in the VTA on motor activity and extracellular dopamine.
Brain research 1992;599(2):209-14.
1992: Pham I; el Amrani A I; Fournié-Zaluski M C; Corvol P; Roques B; Michel J B
Effects of the selective neutral endopeptidase inhibitor, retrothiorphan, on renal function and blood pressure in conscious normotensive Wistar and hypertensive DOCA-salt rats.
Journal of cardiovascular pharmacology 1992;20(6):847-57.
1992: Noble F; Coric P; Fournié-Zaluski M C; Roques B P
Lack of physical dependence in mice after repeated systemic administration of the mixed inhibitor prodrug of enkephalin-degrading enzymes, RB101.
European journal of pharmacology 1992;223(1):91-6.
1992: Noble F; Turcaud S; Fournié-Zaluski M C; Roques B P
Repeated systemic administration of the mixed inhibitor of enkephalin-degrading enzymes, RB101, does not induce either antinociceptive tolerance or cross-tolerance with morphine.
European journal of pharmacology 1992;223(1):83-9.
1992: Dauge V; Derrien M; Durieux C; Noble F; Corringer P J; Roques B P
[Study of induced effects by selective CCKB agonists cholecystokinin in the nociception and behavior in rodents]
Thérapie 1992;47(6):531-9.
1992: Akopyan T N; Couedel Y; Beaumont A; Fournie-Zaluski M C; Roques B P
Cleavage of farnesylated COOH-terminal heptapeptide of mouse N-ras by brain microsomal membranes: evidence for a carboxypeptidase which specifically removes the COOH-terminal methionine.
Biochemical and biophysical research communications 1992;187(3):1336-42.
1992: Morellet N; Jullian N; De Rocquigny H; Maigret B; Darlix J L; Roques B P
Determination of the structure of the nucleocapsid protein NCp7 from the human immunodeficiency virus type 1 by 1H NMR.
The EMBO journal 1992;11(8):3059-65.
1992: Milhiet P E; Dennin F; Giocondi M C; Le Grimellec C; Garbay-Jaureguiberry C; Boucheix C; Roques B P
Detection of neutral endopeptidase-24.11/CD10 by flow cytometry and photomicroscopy using a new fluorescent inhibitor.
Analytical biochemistry 1992;205(1):57-64.
1992: De Rocquigny H; Gabus C; Vincent A; Fournié-Zaluski M C; Roques B; Darlix J L
Viral RNA annealing activities of human immunodeficiency virus type 1 nucleocapsid protein require only peptide domains outside the zinc fingers.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(14):6472-6.
1992: Fournié-Zaluski M C; Soleilhac J M; Turcaud S; Laï-Kuen R; Crine P; Beaumont A; Roques B P
Development of [125I]RB104, a potent inhibitor of neutral endopeptidase 24.11, and its use in detecting nanogram quantities of the enzyme by "inhibitor gel electrophoresis".
Proceedings of the National Academy of Sciences of the United States of America 1992;89(14):6388-92.
1992: Durieux C; Ruiz-Gayo M; Corringer P J; Bergeron F; Ducos B; Roques B P
[3H]pBC 264, a suitable probe for studying cholecystokinin-B receptors: binding characteristics in rodent brains and comparison with [3H]SNF 8702.
Molecular pharmacology 1992;41(6):1089-95.
1992: Garbay-Jaureguiberry C; Ficheux D; Roques B P
Solid phase synthesis of peptides containing the non-hydrolysable analog of (O)phosphotyrosine, p(CH2PO3H2)Phe. Application to the synthesis of 344-357 sequences of the beta 2 adrenergic receptor.
International journal of peptide and protein research 1992;39(6):523-7.
1992: Gopalakrishnan B; Roques B P
Do antigenic peptides have a unique sense of direction inside the MHC binding groove? A molecular modelling study.
FEBS letters 1992;303(2-3):224-8.
1992: Fournié-Zaluski M C; Coric P; Turcaud S; Lucas E; Noble F; Maldonado R; Roques B P
"Mixed inhibitor-prodrug" as a new approach toward systemically active inhibitors of enkephalin-degrading enzymes.
Journal of medicinal chemistry 1992;35(13):2473-81.
1992: Baamonde A; Daugé V; Ruiz-Gayo M; Fulga I G; Turcaud S; Fournié-Zaluski M C; Roques B P
Antidepressant-type effects of endogenous enkephalins protected by systemic RB 101 are mediated by opioid delta and dopamine D1 receptor stimulation.
European journal of pharmacology 1992;216(2):157-66.
1992: Maldonado R; Fournié-Zaluski M C; Roques B P
Attenuation of the morphine withdrawal syndrome by inhibition of catabolism of endogenous enkephalins in the periaqueductal gray matter.
Naunyn-Schmiedeberg's archives of pharmacology 1992;345(4):466-72.
1992: Noble F; Soleilhac J M; Soroca-Lucas E; Turcaud S; Fournie-Zaluski M C; Roques B P
Inhibition of the enkephalin-metabolizing enzymes by the first systemically active mixed inhibitor prodrug RB 101 induces potent analgesic responses in mice and rats.
The Journal of pharmacology and experimental therapeutics 1992;261(1):181-90.
1992: Milhiet P E; Beaumont A; Garbay-Jaureguiberry C; Roques B P
Increase of neutral endopeptidase-24.11 with cellular density and enzyme modulation with an inhibitor on human Reh6 cell line.
Biochemical pharmacology 1992;43(8):1711-5.
1992: Soleilhac J M; Lucas E; Beaumont A; Turcaud S; Michel J B; Ficheux D; Fournié-Zaluski M C; Roques B P
A 94-kDa protein, identified as neutral endopeptidase-24.11, can inactivate atrial natriuretic peptide in the vascular endothelium.
Molecular pharmacology 1992;41(4):609-14.
1992: Fournié-Zaluski M C; Coric P; Turcaud S; Bruetschy L; Lucas E; Noble F; Roques B P
Potent and systemically active aminopeptidase N inhibitors designed from active-site investigation.
Journal of medicinal chemistry 1992;35(7):1259-66.
1992: Roques B P
Peptidomimetics as receptors agonists or peptidase inhibitors: a structural approach in the field of enkephalins, ANP and CCK.
Biopolymers 1992;32(4):407-10.
1992: Helene A; Milhiet P E; Haouas H; Boucheix C; Beaumont A; Roques B P
Effects of monoclonal antibodies raised against the common acute lymphoblastic leukemia antigen on endopeptidase-24.11 activity.
Biochemical pharmacology 1992;43(4):809-14.
1992: Ruiz-Gayo M; Baamonde A; Turcaud S; Fournie-Zaluski M C; Roques B P
In vivo occupation of mouse brain opioid receptors by endogenous enkephalins: blockade of enkephalin degrading enzymes by RB 101 inhibits [3H]diprenorphine binding.
Brain research 1992;571(2):306-12.
1992: Garbay-Jaureguiberry C; Barsi M C; Jacquemin-Sablon A; Le Pecq J B; Roques B P
Synthesis and biological activity of new dimers in the 7H-pyrido[4,3-c] carbazole antitumor series.
Journal of medicinal chemistry 1992;35(1):72-81.
1992: Daugé V; Derrien M; Blanchard J C; Roques B P
The selective CCK-B agonist, BC 264 injected in the antero-lateral part of the nucleus accumbens, reduces the spontaneous alternation behaviour of rats.
Neuropharmacology 1992;31(1):67-75.
1992: McCort-Tranchepain I; Ficheux D; Durieux C; Roques B P
Replacement of Tyr-SO3H by a p-carboxymethyl-phenylalanine in a CCK8-derivative preserves its high affinity for CCK-B receptor.
International journal of peptide and protein research 1992;39(1):48-57.
1992: Morin-Surun M P; Boudinot E; Fournie-Zaluski M C; Champagnat J; Roques B P; Denavit-Saubie M
Control of breathing by endogenous opioid peptides: possible involvement in sudden infant death syndrome.
Neurochemistry international 1992;20(1):103-7.
1992: Noble F; Roques B P
[Selective opioid agonists and inhibitors of enkephalin degradation enzymes: pharmacological and clinical values]
Comptes rendus des séances de la Société de biologie et de ses filiales 1992;186(1-2):37-60.
1991: Durieux C; Ruiz-Gayo M; Roques B P
In vivo binding affinities of cholecystokinin agonists and antagonists determined using the selective CCKB agonist [3H]pBC 264.
European journal of pharmacology 1991;209(3):185-93.
1991: Calenco-Choukroun G; Daugé V; Gacel G; Roques B P
Lesion of dopamine mesolimbic neurons blocks behavioral effects induced by the endogenous enkephalins but not by a mu-opioid receptor agonist.
European journal of pharmacology 1991;209(3):267-71.
1991: de Rocquigny H; Ficheux D; Gabus C; Fournié-Zaluski M C; Darlix J L; Roques B P
First large scale chemical synthesis of the 72 amino acid HIV-1 nucleocapsid protein NCp7 in an active form.
Biochemical and biophysical research communications 1991;180(2):1010-8.
1991: Pothier J; Delepierre M; Barsi M C; Garbay-Jaureguiberry C; Igolen J; Le Bret M; Roques B P
Comparison of the bis-intercalating complexes formed between either ditercalinium or a flexible analogue and d(CpGpCpG)2 or d(TpTpCpGpCpGpApA)2 minihelices: 1H- and 31P-NMR analyses.
Biopolymers 1991;31(11):1309-23.
1991: Crawley J N; Fiske S M; Durieux C; Derrien M; Roques B P
Centrally administered cholecystokinin suppresses feeding through a peripheral-type receptor mechanism.
The Journal of pharmacology and experimental therapeutics 1991;257(3):1076-80.
1991: Mely Y; Cornille F; Fournié-Zaluski M C; Darlix J L; Roques B P; Gérard D
Investigation of zinc-binding affinities of Moloney murine leukemia virus nucleocapsid protein and its related zinc finger and modified peptides.
Biopolymers 1991;31(7):899-906.
1991: Pattou D; Maigret B; Fournie-Zaluski M C; Roques B P
Computational analysis of conformational behavior of cholecystokinin fragments. I-CCK4, CCK5, CCK6 and CCK7 molecules.
International journal of peptide and protein research 1991;37(5):440-50.
1991: Barcelo F; Muzard G; Mendoza R; Révet B; Roques B P; Le Pecq J B
Removal of DNA curving by DNA ligands: gel electrophoresis study.
Biochemistry 1991;30(20):4863-73.
1991: Bado A; Durieux C; Moizo L; Roques B P; Lewin M J
Cholecystokinin-A receptor mediation of food intake in cats.
The American journal of physiology 1991;260(4 Pt 2):R693-7.
1991: Gonzalez-Muniz R; Cornille F; Bergeron F; Ficheux D; Pothier J; Durieux C; Roques B P
Solid phase synthesis of a fully active analogue of cholecystokinin using the acid-stable Boc-Phe (p-CH2) SO3H as a substitute for Boc-Tyr(SO3H) in CCK8.
International journal of peptide and protein research 1991;37(4):331-40.
1991: de Saint Hilaire Z; Roques B P; Nicolaïdis S
Effect of a highly selective central CCK-B receptor agonist: BC-264 on rat sleep.
Pharmacology, biochemistry, and behavior 1991;38(3):545-8.
1991: Helene A; Beaumont A; Roques B P
Functional residues at the active site of aminopeptidase N.
European journal of biochemistry / FEBS 1991;196(2):385-93.
1991: Schmidt C; Peyroux J; Noble F; Fournié-Zaluski M C; Roques B P
Analgesic responses elicited by endogenous enkephalins (protected by mixed peptidase inhibitors) in a variety of morphine-sensitive noxious tests.
European journal of pharmacology 1991;192(2):253-62.
1991: Maroun R C; Roques B P
Induction of DNA bending by bifunctional intercalating agents of the 7H-pyridocarbazole family.
Biophysical chemistry 1991;39(1):45-56.
1991: Delay-Goyet P; Ruiz-Gayo M; Baamonde A; Gacel G; Morgat J L; Roques B P
Brain passage of BUBU, a highly selective and potent agonist for delta opioid receptors: in vivo binding and mu versus delta receptors occupancy.
Pharmacology, biochemistry, and behavior 1991;38(1):155-62.
1991: Calenco-Choukroun G; Daugé V; Gacel G; Féger J; Roques B P
Opioid delta agonists and endogenous enkephalins induce different emotional reactivity than mu agonists after injection in the rat ventral tegmental area.
Psychopharmacology 1991;103(4):493-502.
1990: Cornille F; Mely Y; Ficheux D; Savignol I; Gerard D; Darlix J L; Fournie-Zaluski M C; Roques B P
Solid phase synthesis of the retroviral nucleocapsid protein NCp10 of Moloney murine leukaemia virus and related "zinc-fingers" in free SH forms. Influence of zinc chelation on structural and biochemical properties.
International journal of peptide and protein research 1990;36(6):551-8.
1990: Gonzalez-Muniz R; Bergeron F; Marseigne I; Durieux C; Roques B P
Boc-Trp-Orn(Z)-Asp-NH2 and derivatives: a new family of CCK antagonists.
Journal of medicinal chemistry 1990;33(12):3199-204.
1990: Roques B P; Gacel G; Daugé V; Baamonde A; Calenco G; Turcaud S; Coric P; Fournié-Zaluski M C
Novel approaches in the development of new analgesics.
Neurophysiologie clinique = Clinical neurophysiology 1990;20(5):369-87.
1990: Gacel G A; Fellion E; Baamonde A; Dauge V; Roques B P
Synthesis, biochemical and pharmacological properties of BUBUC, a highly selective and systemically active agonist for in vivo studies of delta-opioid receptors.
Peptides 1990;11(5):983-8.
1990: Roques B P; Beaumont A
Neutral endopeptidase-24.11 inhibitors: from analgesics to antihypertensives?
Trends in pharmacological sciences 1990;11(6):245-9.
1990: Zajac J M; Bigeard A; Delay-Goyet P; Roques B P
Affinity states of rat brain opioid receptors in different tissue preparations.
Journal of neurochemistry 1990;54(3):992-9.
1990: Lambert B; Segal-Bendirdjian E; Esnault C; Le Pecq J B; Roques B P; Jones B; Yeung A T
Recognition by the DNA repair system of DNA structural alterations induced by reversible drug-DNA interactions.
Anti-cancer drug design 1990;5(1):43-53.
1990: Esnault C; Brown S C; Segal-Bendirdjian E; Coulaud D; Mishal Z; Roques B P; Le Pecq J B
Selective alteration of mitochondrial function by Ditercalinium (NSC 335153), a DNA bisintercalating agent.
Biochemical pharmacology 1990;39(1):109-22.
1990: Dauge V; Bohme G A; Crawley J N; Durieux C; Stutzmann J M; Feger J; Blanchard J C; Roques B P
Investigation of behavioral and electrophysiological responses induced by selective stimulation of CCKB receptors by using a new highly potent CCK analog, BC 264.
Synapse (New York, N.Y.) 1990;6(1):73-80.
1990: Calenco-Choukroun G; Daugé V; Féger J; Roques B P
Behavioral effects of endogenous or exogenous (mu, delta) opioid peptides: relation with DA mesolimbic pathways.
Progress in clinical and biological research 1990;328():417-20.
1989: Maroun R; Delepierre M; Roques B P
Intercalative binding of ditercalinium to d(CpGpCpG)2: a theoretical study.
Journal of biomolecular structure & dynamics 1989;7(3):607-21.
1989: Delepierre M; Van Heijenoort C; Igolen J; Pothier J; Le Bret M; Roques B P
Reassessment of structural characteristics of the d(CGCG)2:actinomycin D complex from complete 1H and 31P NMR.
Journal of biomolecular structure & dynamics 1989;7(3):557-89.
1989: Delay-Goyet P; Kayser V; Zajac J M; Guilbaud G; Besson J M; Roques B P
Lack of significant changes in mu, delta opioid binding sites and neutral endopeptidase EC 3.4.24.11 in the brain and spinal cord of arthritic rats.
Neuropharmacology 1989;28(12):1341-8.
1989: Delepierre M; Maroun R; Garbay-Jaureguiberry C; Igolen J; Roques B P
1H and 31P nuclear magnetic resonance studies of the differences in DNA deformation induced by anti-tumoral 7H-pyrido[4,3-c]carbazole dimers.
Journal of molecular biology 1989;210(1):211-28.
1989: Meucci E; Delay-Goyet P; Roques B P; Zajac J M
Binding in vivo of selective mu and delta opioid receptor agonists: opioid receptor occupancy by endogenous enkephalins.
European journal of pharmacology 1989;171(2-3):167-78.
1989: Lanaud P; Popovici T; Normand E; Lemoine C; Bloch B; Roques B P
Distribution of CCK mRNA in particular regions (hippocampus, periaqueductal grey and thalamus) of the rat by in situ hybridization.
Neuroscience letters 1989;104(1-2):38-42.
1989: Lambert B; Jones B K; Roques B P; Le Pecq J B; Yeung A T
The noncovalent complex between DNA and the bifunctional intercalator ditercalinium is a substrate for the UvrABC endonuclease of Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(17):6557-61.
1989: Daugé V; Steimes P; Derrien M; Beau N; Roques B P; Féger J
CCK8 effects on motivational and emotional states of rats involve CCKA receptors of the postero-median part of the nucleus accumbens.
Pharmacology, biochemistry, and behavior 1989;34(1):157-63.
1989: Durieux C; Corringer P J; Bergeron F; Roques B P
[3H]pBC 264, first highly potent and very selective radioligand for CCK-B receptors.
European journal of pharmacology 1989;168(2):269-70.
1989: Xie J; Soleilhac J M; Renwart N; Peyroux J; Roques B P; Fournié-Zaluski M C
Inhibitors of the enkephalin degrading enzymes. Modulation of activity of hydroxamate containing compounds by modifications of the C-terminal residue.
International journal of peptide and protein research 1989;34(3):246-55.
1989: Belleney J; Gacel G; Fournié-Zaluski M C; Maigret B; Roques B P
Delta opioid receptor selectivity induced by conformational constraints in linear enkephalin-related peptides: 1H 400-MHz NMR study and theoretical calculations.
Biochemistry 1989;28(18):7392-400.
1989: Delay-Goyet P; Zajac J M; Roques B P
Effects of repeated treatment with haloperidol on rat striatal neutral endopeptidase, and on mu- and delta-opioid binding sites: comparison with chronic morphine and chronic kelatorphan.
Neuroscience letters 1989;103(2):197-202.
1989: Jamin N; Roy P; Fridlansky F; Delepierre M; Milgrom E; Roques B P; Mornon J P
Preliminary assignments of the aromatic and some methyl group resonances of the 1H-NMR spectrum of the oxidized form of uteroglobin. Application to the interaction of oxidized uteroglobin with progesterone.
European journal of biochemistry / FEBS 1989;183(1):219-26.
1989: Xie J; Soleilhac J M; Schmidt C; Peyroux J; Roques B P; Fournié-Zaluski M C
New kelatorphan-related inhibitors of enkephalin metabolism: improved antinociceptive properties.
Journal of medicinal chemistry 1989;32(7):1497-503.
1989: Charpentier B; Dor A; Roy P; England P; Pham H; Durieux C; Roques B P
Synthesis and binding affinities of cyclic and related linear analogues of CCK8 selective for central receptors.
Journal of medicinal chemistry 1989;32(6):1184-90.
1989: Beaumont A; Brouet J C; Roques B P
Neutral endopeptidase 24.11 and angiotensin converting enzyme like activity in CALLA positive and CALLA negative lymphoid cells.
Biochemical and biophysical research communications 1989;160(3):1323-9.
1989: Daugé V; Dor A; Féger J; Roques B P
The behavioral effects of CCK8 injected into the medial nucleus accumbens are dependent on the motivational state of the rat.
European journal of pharmacology 1989;163(1):25-32.
1989: Rigaudy P; Charcosset J Y; Garbay-Jaureguiberry C; Jacquemin-Sablon A; Roques B P
Attempts to target antitumor drugs toward opioid receptor-rich mouse tumor cells with enkephalin-ellipticinium conjugates.
Cancer research 1989;49(7):1836-42.
1989: Markovits J; Garbay-Jaureguiberry C; Roques B P; Le Pecq J B
Acridine dimers: influence of the intercalating ring and of the linking-chain nature on the equilibrium and kinetic DNA-binding parameters.
European journal of biochemistry / FEBS 1989;180(2):359-66.
1989: Fournié-Zaluski M C; Hernandez J F; Soleilhac J M; Renwart N; Peyroux J; Xie J; Roques B P
Enkephalin-degrading enzyme inhibitors. Crucial role of the C-terminal residue on the inhibitory potencies of retro-hydroxamate dipeptides.
International journal of peptide and protein research 1989;33(2):146-53.
1989: Marseigne I; Roy P; Dor A; Durieux C; Pélaprat D; Reibaud M; Blanchard J C; Roques B P
Full agonists of CCK8 containing a nonhydrolyzable sulfated tyrosine residue.
Journal of medicinal chemistry 1989;32(2):445-9.
1989: Roy P; Charpentier B; Durieux C; Dor A; Roques B P
Conformational behavior of cyclic CCK-related peptides determined by 400-MHz 1H-NMR: relationships with affinity and selectivity for brain receptors.
Biopolymers 1989;28(1):69-79.
1989: Pelaprat D; Dauge V; Durieux C; Charpentier B; Roques B P
[Co-localization of CCK and dopamine. Biochemical and pharmacological aspects]
L'Encéphale 1989;15 Spec No():85-9.
1989: Daugé V; Rossignol P; Roques B P
Blockade of dopamine receptors reverses the behavioral effects of endogenous enkephalins in the Nucleus caudatus but not in the Nucleus accumbens: differential involvement of delta and mu opioid receptors.
Psychopharmacology 1989;99(2):168-75.
1988: Laugaa P; Delepierre M; Dupraz B; Igolen J; Roques B P
NMR studies of tris-intercalation: solution structure and interaction of d(CTTCGCGCGAAG) with an acridine trimer.
Journal of biomolecular structure & dynamics 1988;6(3):421-41.
1988: Fellous R; Coulaud D; el Abed I; Roques B P; Le Pecq J B; Delain E; Gouyette A
Cytoplasmic accumulation of ditercalinium in rat hepatocytes and induction of mitochondrial damage.
Cancer research 1988;48(22):6542-9.
1988: Durieux C; Pélaprat D; Charpentier B; Morgat J L; Roques B P
Characterization of [3H] CCK4 binding sites in mouse and rat brain.
Neuropeptides 1988;12(3):141-8.
1988: Bochet P; Icard-Liepkalns C; Pasquini F; Garbay-Jaureguiberry C; Beaudet A; Roques B; Rossier J
Photoaffinity labeling of opioid delta receptors with an iodinated azido-ligand: [125I][D-Thr2,pN3Phe4,Leu5]enkephalyl-Thr6.
Molecular pharmacology 1988;34(4):436-43.
1988: Gacel G; Daugé V; Breuzé P; Delay-Goyet P; Roques B P
Development of conformationally constrained linear peptides exhibiting a high affinity and pronounced selectivity for delta opioid receptors.
Journal of medicinal chemistry 1988;31(10):1891-7.
1988: Hernandez J F; Soleilhac J M; Roques B P; Fournié-Zaluski M C
Retro-inverso concept applied to the complete inhibitors of enkephalin-degrading enzymes.
Journal of medicinal chemistry 1988;31(9):1825-31.
1988: Segal-Bendirdjian E; Coulaud D; Roques B P; Le Pecq J B
Selective loss of mitochondrial DNA after treatment of cells with ditercalinium (NSC 335153), an antitumor bis-intercalating agent.
Cancer research 1988;48(17):4982-92.
1988: Charpentier B; Durieux C; Pelaprat D; Dor A; Reibaud M; Blanchard J C; Roques B P
Enzyme-resistant CCK analogs with high affinities for central receptors.
Peptides 1988;9(4):835-41.
1988: Delepierre M; Igolen J; Roques B P
Study of the bisintercalation of the antitumor drug ditercalinium by 31P-NMR.
Biopolymers 1988;27(6):957-68.
1988: Léon P; Garbay-Jaureguiberry C; Le Pecq J B; Roques B P
Relationship between the size and position of substituents on 7H-pyrido[4,3-c]carbazole monomers and dimers and their DNA binding and anti-tumor properties.
Anti-cancer drug design 1988;3(1):1-13.
1988: Léon P; Garbay-Jaureguiberry C; Lambert B; Le Pecq J B; Roques B P
Asymmetrical bisintercalators as potential antitumor agents.
Journal of medicinal chemistry 1988;31(5):1021-6.
1988: Marseigne I; Dor A; Bégué D; Reibaud M; Zundel J L; Blanchard J C; Pélaprat D; Roques B P
Synthesis and biological activity of CCK26-33-related analogues modified in position 31.
Journal of medicinal chemistry 1988;31(5):966-70.
1988: Shafer R H; Roques B P; LePecq J B; Delepierre M
Chromomycin A3 binds to left-handed poly(dG-m5dC).
European journal of biochemistry / FEBS 1988;173(2):377-82.
1988: Charpentier B; Pelaprat D; Durieux C; Dor A; Reibaud M; Blanchard J C; Roques B P
Cyclic cholecystokinin analogues with high selectivity for central receptors.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(6):1968-72.
1988: Delay-Goyet P; Seguin C; Gacel G; Roques B P
[3H][D-Ser2(O-tert-butyl),Leu5]enkephalyl-Thr6 and [D-Ser2(O-tert-butyl),Leu5]enkephalyl-Thr6(O-tert-butyl). Two new enkephalin analogs with both a good selectivity and a high affinity toward delta-opioid binding sites.
The Journal of biological chemistry 1988;263(9):4124-30.
1988: Delepierre M; Roques B P; Langlois D'Estaintot B; Igolen J
A general procedure for assigning the 31P spectra of drug-oligonucleotide complexes.
Journal of biomolecular structure & dynamics 1988;5(4):933-7.
1988: Gacel G; Zajac J M; Delay-Goyet P; Daugé V; Roques B P
Investigation of the structural parameters involved in the mu and delta opioid receptor discrimination of linear enkephalin-related peptides.
Journal of medicinal chemistry 1988;31(2):374-83.
1988: Benchetrit T; Bissery V; Mornon J P; Devault A; Crine P; Roques B P
Primary structure homologies between two zinc metallopeptidases, the neutral endopeptidase 24.11 ("enkephalinase") and thermolysin, through clustering analysis.
Biochemistry 1988;27(2):592-6.
1988: Daugé V; Rossignol P; Roques B P
Comparison of the behavioural effects induced by administration in rat nucleus accumbens or nucleus caudatus of selective mu and delta opioid peptides or kelatorphan an inhibitor of enkephalin-degrading-enzymes.
Psychopharmacology 1988;96(3):343-52.
1987: Waksman G; Hamel E; Delay-Goyet P; Roques B P
Neutral endopeptidase-24.11, mu and delta opioid receptors after selective brain lesions: an autoradiographic study.
Brain research 1987;436(2):205-16.
1987: Léon P; Garbay-Jaureguiberry C; Barsi M C; Le Pecq J B; Roques B P
Modulation of the antitumor activity by methyl substitutions in the series of 7H-pyridocarbazole monomers and dimers.
Journal of medicinal chemistry 1987;30(11):2074-80.
1987: Beaumont A; Hernandez J F; Chaillet P; Crine P; Roques B P
Irreversible photolabeling of active site of neutral endopeptidase-24.11 "enkephalinase" by azidothiorphan and [14C]-azidothiorphan.
Molecular pharmacology 1987;32(5):594-9.
1987: Belleney J; Roques B P; Fournie-Zaluski M C
Comparison of conformational properties of linear and cyclic delta selective opioid ligands DTLET (Tyr-D X Thr-Gly-Phe-Leu-Thr) and DPLPE (Tyr-c[D X Pen-Gly-Phe-Pen]) by 1H n.m.r. spectroscopy.
International journal of peptide and protein research 1987;30(3):356-64.
1987: Rigaudy P; Garbay-Jaureguiberry C; Jacquemin-Sablon A; Le Pecq J B; Roques B P
Synthesis and binding properties to DNA and to opioid receptors of enkephalin-ellipticinium conjugates.
International journal of peptide and protein research 1987;30(3):347-55.
1987: Dauge V; Petit F; Rossignol P; Roques B P
Use of mu and delta opioid peptides of various selectivity gives further evidence of specific involvement of mu opioid receptors in supraspinal analgesia (tail-flick test).
European journal of pharmacology 1987;141(2):171-8.
1987: Delay-Goyet P; Roques B P; Zajac J M
Differences of binding characteristics of non-selective opiates towards mu and delta receptor types.
Life sciences 1987;41(6):723-31.
1987: Delepierre M; Delbarre A; Langlois d'Estaintot B; Igolen J; Roques B P
1H-NMR studies of a monointercalating drug into a d[CpGpCpG]2 minihelix.
Biopolymers 1987;26(7):981-1000.
1987: Delbarre A; Delepierre M; Langlois d'Estaintot B; Igolen J; Roques B P
Bisintercalation of ditercalinium into a d[CpGpCpG]2 minihelix: structure and dynamics aspects--a 400-MHz 1H-NMR study.
Biopolymers 1987;26(7):1001-33.
1987: Roy P; Delepierre M; Wagnon J; Nisato D; Roques B P
Conformational analysis of pepstatin and related renin inhibitors by 400 MHz 1H n.m.r. spectroscopy.
International journal of peptide and protein research 1987;30(1):44-53.
1987: Delay-Goyet P; Zajac J M; Javoy-Agid F; Agid Y; Roques B P
Regional distribution of mu, delta and kappa opioid receptors in human brains from controls and parkinsonian subjects.
Brain research 1987;414(1):8-14.
1987: Delbarre A; Delepierre M; Garbay C; Igolen J; Le Pecq J B; Roques B P
Geometry of the antitumor drug ditercalinium bisintercalated into d(CpGpCpG)2 by 1H NMR.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(8):2155-9.
1987: Garbay-Jaureguiberry C; Laugâa P; Delepierre M; Laalami S; Muzard G; Le Pecq J B; Roques B P
DNA bis-intercalators as new anti-tumour agents: modulation of the anti-tumour activity by the linking chain rigidity in the ditercalinium series.
Anti-cancer drug design 1987;1(4):323-35.
1987: Garbay-Jaureguiberry C; Esnault C; Delepierre M; Laugaa P; Laalami S; Le Pecq J B; Roques B P
Rational design of bis-intercalating drugs as antitumour agents: importance of rigidity in the linking chain.
Drugs under experimental and clinical research 1987;13(6):353-7.
1986: Waksman G; Hamel E; Delay-Goyet P; Roques B P
Neuronal localization of the neutral endopeptidase 'enkephalinase' in rat brain revealed by lesions and autoradiography.
The EMBO journal 1986;5(12):3163-6.
1986: Delepierre M; Langlois D'Estaintot B; Igolen J; Roques B P
Conformational studies of d(m5CpGpm5CpG) and d(CpGpCpG) by 1H and 31P NMR.
European journal of biochemistry / FEBS 1986;161(3):571-7.
1986: Benoist J M; Kayser V; Gacel G; Zajac J M; Gautron M; Roques B; Guilbaud G
Differential depressive action of two mu and delta opioid ligands on neuronal responses to noxious stimuli in the thalamic ventrobasal complex of rat.
Brain research 1986;398(1):49-56.
1986: Markovits J; Pommier Y; Mattern M R; Esnault C; Roques B P; Le Pecq J B; Kohn K W
Effects of the bifunctional antitumor intercalator ditercalinium on DNA in mouse leukemia L1210 cells and DNA topoisomerase II.
Cancer research 1986;46(11):5821-6.
1986: Lambert B; Laugâa P; Roques B P; le Pecq J B
Cytotoxicity and SOS-inducing ability of ethidium and photoactivable analogs on E. coli ethidium-bromide-sensitive (Ebs) strains.
Mutation research 1986;166(3):243-54.
1986: Lescot E; Muzard G; Markovits J; Belleney J; Roques B P; Le Pecq J B
Synthesis of 11H-pyridocarbazoles and derivatives. Comparison of their DNA binding and antitumor activity with those of 6H- and 7H-pyridocarbazoles.
Journal of medicinal chemistry 1986;29(9):1731-7.
1986: Fournié-Zaluski M C; Belleney J; Lux B; Durieux C; Gérard D; Gacel G; Maigret B; Roques B P
Conformational analysis of cholecystokinin CCK26-33 and related fragments by 1H NMR spectroscopy, fluorescence-transfer measurements, and calculations.
Biochemistry 1986;25(13):3778-87.
1986: Maigret B; Fournie-Zaluski M C; Roques B; Premilat S
Proposals for the mu-active conformation of the enkephalin analog Tyr-cyclol(-N gamma-D-A2-bu-Gly-Phe-Leu-).
Molecular pharmacology 1986;29(3):314-20.
1986: Durieux C; Charpentier B; Pelaprat D; Roques B P
Investigation on the metabolism of CCK8 analogues by rat brain slices.
Neuropeptides 1986;7(1):1-9.
1986: Delay-Goyet P; Seguin C; Daugé V; Calenco G; Morgat J L; Gacel G; Roques B P
[3H]DSTBULET, a new linear hexapeptide with both an improved selectivity and a high affinity for delta-opioid receptors.
NIDA research monograph 1986;75():197-200.
1985: Pélaprat D; Zajac J M; Gacel G; Durieux C; Morgat J L; Sasaki A; Roques B P
[3H] Boc [Nle28, 31]CCK27-33, a new highly labelled ligand for CCK receptors: binding on brain and on pancreas.
Life sciences 1985;37(26):2483-90.
1985: Fournie-Zaluski M C; Durieux C; Lux B; Belleney J; Pham P; Gerard D; Roques B P
Conformational analysis of cholecystokinin fragments CCK4, CCK5, and CCK6 by 1H-NMR spectroscopy and fluorescence-transfer measurements.
Biopolymers 1985;24(9):1663-81.
1985: Laugâa P; Markovits J; Delbarre A; Le Pecq J B; Roques B P
DNA tris-intercalation: first acridine trimer with DNA affinity in the range of DNA regulatory proteins. Kinetic studies.
Biochemistry 1985;24(20):5567-75.
1985: Delbarre A; Delepierre M; Igolen J; Le Pecq J B; Roques B P
1H NMR study of the structure of a pyridocarbazole dimer-d[CpGpCpG] complex.
Biochimie 1985;67(7-8):823-8.
1985: Delbarre A; Oberlin R; Roques B P; Borgna J L; Rochefort H; Le Pecq J B; Jacquemin-Sablon A
Ellipticine derivatives with an affinity to the estrogen receptor, an approach to develop intercalating drugs with a specific effect on the hormone-dependent breast cancer.
Journal of medicinal chemistry 1985;28(6):752-61.
1985: Durieux C; Charpentier B; Fellion E; Gacel G; Pelaprat D; Roques B P
Multiple cleavage sites of cholecystokinin heptapeptide by "enkephalinase".
Peptides 1985;6(3):495-501.
1985: Delay-Goyet P; Zajac J M; Rigaudy P; Foucaud B; Roques B P
Comparative binding properties of linear and cyclic delta-selective enkephalin analogues: [3H]-[D-Thr2, Leu5] enkephalyl-Thr6 and [3H]-[D-Pen2, D-Pen5] enkephalin.
FEBS letters 1985;183(2):439-43.
1985: Roques B P; Durieux C; Gacel G; Pélaprat D; Ruiz-Gayo M; Belleney J; Fellion E; Zajac J M; Fournié-Zaluski M C; Daugé V
Studies on the conformation, enzymatic degradation, pharmacological potency, and binding properties in brain tissue of cholecystokinin-8 and new related peptides.
Annals of the New York Academy of Sciences 1985;448():61-75.
1984: Garbay-Jaureguiberry C; Robichon A; Daugé V; Rossignol P; Roques B P
Highly selective photoaffinity labeling of mu and delta opioid receptors.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(24):7718-22.
1984: Esnault C; Roques B P; Jacquemin-Sablon A; Le Pecq J B
Effects of new antitumor bifunctional intercalators derived from 7H-pyridocarbazole on sensitive and resistant L 1210 cells.
Cancer research 1984;44(10):4355-60.
1984: Gaugain B; Markovits J; Le Pecq J B; Roques B P
DNA polyintercalation: comparison of DNA binding properties of an acridine dimer and trimer.
FEBS letters 1984;169(2):123-6.
1984: Morin-Surun M P; Boudinot E; Gacel G; Champagnat J; Roques B P; Denavit-Saubie M
Different effects of mu and delta opiate agonists on respiration.
European journal of pharmacology 1984;98(2):235-40.
1983: Durieux C; Belleney J; Lallemand J Y; Roques B P; Fournie-Zaluski M C
1H NMR conformational study of sulfated and non-sulfated cholecystokinin fragment CCK27-33: influence of the sulfate group on the peptide folding.
Biochemical and biophysical research communications 1983;114(2):705-12.
1983: Delbarre A; Gourevitch M I; Gaugain B; Le Pecq J B; Roques B P
1H NMR study of an ethidium dimer poly(dA-dT) complex: evidence of a transition between bis and monointercalation.
Nucleic acids research 1983;11(13):4467-82.
1983: Laugaa P; Delbarre A; Le Pecq J B; Roques B P
Comparative binding of ethidium and three azido analogs to dinucleotides: affinity and intercalation geometry. A 1H NMR and visible spectroscopy study.
European journal of biochemistry / FEBS 1983;134(1):163-73.
1983: Zajac J M; Gacel G; Petit F; Dodey P; Rossignol P; Roques B P
Deltakephalin, Tyr-D-Thr-Gly-Phe-Leu-Thr: a new highly potent and fully specific agonist for opiate delta-receptors.
Biochemical and biophysical research communications 1983;111(2):390-7.
1983: Fournié-Zaluski M C; Chaillet P; Soroca-Lucas E; Marçais-Collado H; Costentin J; Roques B P
New carboxyalkyl inhibitors of brain enkephalinase: synthesis, biological activity, and analgesic properties.
Journal of medicinal chemistry 1983;26(1):60-5.
1982: Fournié-Zaluski M C; Soroca-Lucas E; Waksman G; Llorens C; Schwartz J C; Roques B P
Differential recognition of "enkephalinase" and angiotensin-converting enzyme by new carboxyalkyl inhibitors.
Life sciences 1982;31(26):2947-54.
1982: Llorens C; Malfroy B; Schwartz J C; Gacel G; Roques B P; Roy J; Morgat J L; Javoy-Agid F; Agid Y
Enkephalin dipeptidyl carboxypeptidase (enkephalinase) activity: selective radioassay, properties, and regional distribution in human brain.
Journal of neurochemistry 1982;39(4):1081-9.
1982: David M; Moisand C; Meunier J C; Morgat J L; Gacel G; Roques B P
[3H]Tyr-D-Ser-Gly-Phe-Leu-Thr: a specific probe for the delta-opiate receptor subtype in brain membranes.
European journal of pharmacology 1982;78(3):385-7.
1982: Schwartz J C; de la Baume S; Llorens C; Malfroy B; Soroca E; Fournié-Zaluski M C; Roques B P; Morgat J L; Roy J; Javoy-Agid F; Agid Y
Enkephalin dipeptidyl carboxypeptidase ("enkephalinase"): assay, properties, and distribution in human brain and exploration of the active site.
Advances in biochemical psychopharmacology 1982;33():225-34.
1982: Roques B P; Fournié-Zaluski M C; Gacel G; David M; Meunier J C; Maigret B; Morgat J L
Rational design and biological properties of highly specific mu and delta opioid peptides.
Advances in biochemical psychopharmacology 1982;33():321-31.
1981: Laugaa P; Delbarre A; Roques B P
1H NMR studies of the interactions of self-associating intercalating agents with dinucleotides: a theoretical analysis.
Biochimie 1981;63(11-12):967-73.
1981: Fournie-Zaluski M C; Gacel G; Maigret B; Premilat S; Roques B P
Structural requirements for specific recognition of mu or delta opiate receptors.
Molecular pharmacology 1981;20(3):484-91.
1981: Gacel G; Fournié-Zaluski M C; Fellion E; Roques B P
Evidence of the preferential involvement of mu receptors in analgesia using enkephalins highly selective for peripheral mu or delta receptors.
Journal of medicinal chemistry 1981;24(10):1119-24.
1981: Patey G; De La Baume S; Schwartz J C; Gros C; Roques B; Fournie-Zaluski M C; Soroca-Lucas E
Selective protection of methionine enkephalin released from brain slices by enkephalinase inhibition.
Science (New York, N.Y.) 1981;212(4499):1153-5.
1981: Markovits J; Gaugain B; Barbet J; Roques B P; Le Pecq J B
Hydrogen bonding in deoxyribonucleic acid base recognition. 2. Deoxyribonucleic acid binding studies of acridine alkylamides.
Biochemistry 1981;20(11):3042-8.
1981: Gaugain B; Markovits J; Le Pecq J B; Roques B P
Hydrogen bonding in deoxyribonucleic acid base recognition. 1. Proton nuclear magnetic resonance studies of dinucleotide-acridine alkylamide complexes.
Biochemistry 1981;20(11):3035-42.
1981: Maigret B; Premilat S; Fournie-Zaluski M C; Roques B P
Proposals for conformation of enkephalins related to opiate mu-pharmacophore.
Biochemical and biophysical research communications 1981;99(1):267-74.
1980: Pelaprat D; Delbarre A; Le Guen I; Roques B P; Le Pecq J B
DNA intercalating compounds as potential antitumor agents. 2. Preparation and properties of 7H-pyridocarbazole dimers.
Journal of medicinal chemistry 1980;23(12):1336-43.
1980: Roques B P; Fournié-Zaluski M C; Soroca E; Lecomte J M; Malfroy B; Llorens C; Schwartz J C
The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice.
Nature 1980;288(5788):286-8.
1980: Llorens C; Gacel G; Swerts J P; Perdrisot R; Fournie-Zaluski M C; Schwartz J C; Roques B P
Rational design of enkephalinase inhibitors: substrate specificity of enkephalinase studied from inhibitory potency of various dipeptides.
Biochemical and biophysical research communications 1980;96(4):1710-6.
1980: Schwartz J C; de la Baume S; Malfroy B; Patey G; Perdrisot R; Swerts J P; Fournié-Zaluski M C; Gacel G; Roques B P
Properties variations and possible synaptic functions of "enkephalinase": a newly characterised dipeptidyl carboxypeptidase.
Advances in biochemical psychopharmacology 1980;22():219-35.
1980: Schwartz J C; de la Baume S; Malfroy B; Patey G; Perdrisot R; Swerts J P; Fournie-Zaluski M C; Gacel G; Roques B P
"Enkephalinase", a newly characterised dipeptidyl carboxypeptidase: properties and possible role in enkephalinergic transmission.
International journal of neurology 1980;14(2-4):195-204.
1980: Schwartz J C; de la Baume S; Malfroy B; Patey G; Perdrisot R; Swerts J P; Fournie-Zaluski M C; Gacel G; Roques B P
"Enkephalinase", a newly characterised dipeptidyl carboxypeptidase: properties and possible role in enkephalinergic transmission.
International journal of neurology 1980;14(2-4):195-204.

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