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Bernard Roques

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Anja Schreiter; Christoph Stein; Bernard P Roques; Marie-Claude Fournie-Zaluski; Carmen Gore; Dominika Labuz; Halina Machelska
Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue.
Yannick Marc; Annie Michaud; Bernard P Roques; Fabrice Balavoine; Ji Gao; Catherine Llorens-Cortes
Central antihypertensive effects of orally active aminopeptidase A inhibitors in spontaneously hypertensive rats.
Florence Noble; Jodie Wilson; Nadia Benturquia; Corinne Canestrelli; Dominique Crete; Magdalena Mas Nieto; Bernard P Roques
Relationship between vulnerability to reinforcing effects of morphine and activity of the endogenous cholecystokinin system in Lewis and Fischer rats.

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2012: Anja Schreiter; Christoph Stein; Bernard P Roques; Marie-Claude Fournie-Zaluski; Carmen Gore; Dominika Labuz; Halina Machelska
Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(12):5161-71.
2012: Yannick Marc; Annie Michaud; Bernard P Roques; Fabrice Balavoine; Ji Gao; Catherine Llorens-Cortes
Central antihypertensive effects of orally active aminopeptidase A inhibitors in spontaneously hypertensive rats.
Hypertension 2012;60(2):411-8.
2012: Florence Noble; Jodie Wilson; Nadia Benturquia; Corinne Canestrelli; Dominique Crete; Magdalena Mas Nieto; Bernard P Roques
Relationship between vulnerability to reinforcing effects of morphine and activity of the endogenous cholecystokinin system in Lewis and Fischer rats.
Addiction biology 2012;17(3):528-38.
2012: Bernard P Roques; Marie-Claude Fournié-Zaluski; Michel Wurm
Inhibiting the breakdown of endogenous opioids and cannabinoids to alleviate pain.
Nature reviews. Drug discovery 2012;11(4):292-310.
2010: Shetal H Padia; Nancy L Howell; Brandon A Kemp; Marie-Claude Fournie-Zaluski; Bernard P Roques; Robert M Carey
Intrarenal aminopeptidase N inhibition restores defective angiontesin II type 2-mediated natriuresis in spontaneously hypertensive rats.
Hypertension 2010;55(2):474-80.
2009: Sara González-Rodríguez; Marta Pevida; Bernard P Roques; Marie-Claude Fournié-Zaluski; Agustín Hidalgo; Luis Menéndez; Ana Baamonde
Involvement of enkephalins in the inhibition of osteosarcoma-induced thermal hyperalgesia evoked by the blockade of peripheral P2X3 receptors.
Neuroscience letters 2009;465(3):285-9.
2008: Sarah Bourbigot; Nick Ramalanjaona; Christian Boudier; Gilmar F J Salgado; Bernard P Roques; Yves Mély; Serge Bouaziz; Nelly Morellet
How the HIV-1 nucleocapsid protein binds and destabilises the (-)primer binding site during reverse transcription.
Journal of molecular biology 2008;383(5):1112-28.
2008: Luis Menéndez; Agustín Hidalgo; Alvaro Meana; Hervé PORAS; Marie-Claude Fournié-Zaluski; Bernard P Roques; Ana Baamonde
Inhibition of osteosarcoma-induced thermal hyperalgesia in mice by the orally active dual enkephalinase inhibitor PL37. Potentiation by gabapentin.
European journal of pharmacology 2008;596(1-3):50-5.
2008: Lu Gao; Mark Nils Hanson; Mini Balakrishnan; Paul L Boyer; Bernard P Roques; Stephen H Hughes; Baek Kim; Robert A Bambara
Apparent defects in processive DNA synthesis, strand transfer, and primer elongation of Met-184 mutants of HIV-1 reverse transcriptase derive solely from a dNTP utilization defect.
The Journal of biological chemistry 2008;283(14):9196-205.
2008: Min Song; Vandana P Basu; Mark Nils Hanson; Bernard P Roques; Robert A Bambara
Proximity and branch migration mechanisms in HIV-1 minus strand strong stop DNA transfer.
The Journal of biological chemistry 2008;283(6):3141-50.
2008: Shetal H Padia; Brandon A Kemp; Nancy L Howell; Marie-Claude Fournie-Zaluski; Bernard P Roques; Robert M Carey
Conversion of renal angiotensin II to angiotensin III is critical for AT2 receptor-mediated natriuresis in rats.
Hypertension 2008;51(2):460-5.
2008: Florence Noble; Nadia Benturquia; Andras Bilkei-Gorzo; Andreas Zimmer; Bernard P Roques
Use of preproenkephalin knockout mice and selective inhibitors of enkephalinases to investigate the role of enkephalins in various behaviours.
Psychopharmacology 2008;196(2):327-35.
2008: Khwaja M Siddiqui; Luis Del Valle; Nelly Morellet; Jianqi Cui; Mohammad Ghafouri; Ruma Mukerjee; Krystyna Urbanska; S Fan; Christopher B Pattillo; Satish L Deshmane; Mohammad F Kiani; Ramin Ansari; Kamel Khalili; Bernard P Roques; Krzysztof Reiss; Serge Bouaziz; Shohreh Amini; Alagarsamy Srinivasan; Bassel E Sawaya
Molecular mimicry in inducing DNA damage between HIV-1 Vpr and the anticancer agent, cisplatin.
Oncogene 2008;27(1):32-43.
2007: N Benturquia; Stéphanie Le Guen; Corinne Canestrelli; V Lagente; G Apiou; Bernard P Roques; Florence Noble
Specific blockade of morphine- and cocaine-induced reinforcing effects in conditioned place preference by nitrous oxide in mice.
Neuroscience 2007;149(3):477-86.
2007: Elisa Bombarda; Ernst Grell; Bernard P Roques; Yves Mély
Molecular mechanism of the Zn2+-induced folding of the distal CCHC finger motif of the HIV-1 nucleocapsid protein.
Biophysical journal 2007;93(1):208-17.
2007: Shetal H Padia; Brandon A Kemp; Nancy L Howell; Helmy M Siragy; Marie-Claude Fournie-Zaluski; Bernard P Roques; Robert M Carey
Intrarenal aminopeptidase N inhibition augments natriuretic responses to angiotensin III in angiotensin type 1 receptor-blocked rats.
Hypertension 2007;49(3):625-30.
2007: Cynthia Marie-Claire; Cindie Courtin; Amelie Robert; Xavier Gidrol; Bernard P Roques; Florence Noble
Sensitization to the conditioned rewarding effects of morphine modulates gene expression in rat hippocampus.
Neuropharmacology 2007;52(2):430-5.
2006: Fanny Jardinaud; Bernard P Roques; Florence Noble
Tolerance to the reinforcing effects of morphine in delta9-tetrahydrocannabinol treated mice.
Behavioural brain research 2006;173(2):255-61.
2006: Emmanuelle N Sabbah; Thierry Delaunay; Audrey Varin; Erwann Le Rouzic; Serge Benichou; Georges Herbein; Sabine Druillennec; Bernard P Roques
Development and characterization of ten monoclonal anti-Vpr antibodies.
AIDS research and human retroviruses 2006;22(7):630-9.
2006: Gabin Sihn; Katia Savary; Annie Michaud; Marie-Claude Fournie-Zaluski; Bernard P Roques; Pierre Corvol; Jean-Marie Gasc
Aminopeptidase N during the ontogeny of the chick.
Differentiation; research in biological diversity 2006;74(2-3):119-28.
2006: Emmanuelle N Sabbah; Sabine Druillennec; Nelly Morellet; Serge Bouaziz; Guido Kroemer; Bernard P Roques
Interaction between the HIV-1 protein Vpr and the adenine nucleotide translocator.
Chemical biology & drug design 2006;67(2):145-54.
2006: Nelly Morellet; Hervé MEUDAL; Serge Bouaziz; Bernard P Roques
Structure of the zinc finger domain encompassing residues 13-51 of the nucleocapsid protein from simian immunodeficiency virus.
The Biochemical journal 2006;393(Pt 3):725-32.
2005: Audrey Varin; Anne-Zélie Decrion; Emmanuelle N Sabbah; Vincent Quivy; Joséphine Sire; Carine Van Lint; Bernard P Roques; Bharat B Aggarwal; Georges Herbein
Synthetic Vpr protein activates activator protein-1, c-Jun N-terminal kinase, and NF-kappaB and stimulates HIV-1 transcription in promonocytic cells and primary macrophages.
The Journal of biological chemistry 2005;280(52):42557-67.
2005: Emmanuelle N Sabbah; Bernard P Roques
Critical implication of the (70-96) domain of human immunodeficiency virus type 1 Vpr protein in apoptosis of primary rat cortical and striatal neurons.
Journal of neurovirology 2005;11(6):489-502.
2005: Fanny Jardinaud; Dominique Crété; Corinne Canestrelli; Catherine Ledent; Bernard P Roques; Florence Noble
CB1 receptor knockout mice show similar behavioral modifications to wild-type mice when enkephalin catabolism is inhibited.
Brain research 2005;1063(1):77-83.
2005: Christine Anne; Serge Turcaud; Armand Blommaert; François Darchen; Eric A Johnson; Bernard P Roques
Partial protection against Botulinum B neurotoxin-induced blocking of exocytosis by a potent inhibitor of its metallopeptidase activity.
Chembiochem : a European journal of chemical biology 2005;6(8):1375-80.
2005: Hervé Beltz; Céline Clauss; Etienne Piémont; Damien Ficheux; Robert J Gorelick; Bernard P Roques; Caroline Gabus; Jean-Luc Darlix; Hugues de Rocquigny; Yves Mély
Structural determinants of HIV-1 nucleocapsid protein for cTAR DNA binding and destabilization, and correlation with inhibition of self-primed DNA synthesis.
Journal of molecular biology 2005;348(5):1113-26.
2005: Elisa Bombarda; Bernard P Roques; Yves Mély; Ernst Grell
Mechanism of zinc coordination by point-mutated structures of the distal CCHC binding motif of the HIV-1 NCp7 protein.
Biochemistry 2005;44(19):7315-25.
2005: Sarah Bourbigot; Hervé Beltz; Jérôme Denis; Nelly Morellet; Bernard P Roques; Yves Mély; Serge Bouaziz
The C-terminal domain of the HIV-1 regulatory protein Vpr adopts an antiparallel dimeric structure in solution via its leucine-zipper-like domain.
The Biochemical journal 2005;387(Pt 2):333-41.
2005: Annabelle Reaux-Le Goazigo; Xavier Iturrioz; Celine Fassot; Cedric Claperon; Bernard P Roques; Catherine Llorens-Cortes
Role of angiotensin III in hypertension.
Current hypertension reports 2005;7(2):128-34.
2005: Nicolas Inguimbert; Pascale Coric; H Dhotel; E Bonnard; Catherine Llorens-Cortes; N Mota; Marie-Claude Fournié-Zaluski; Bernard P Roques
Synthesis and in vitro activities of new non-peptidic APA inhibitors.
The journal of peptide research : official journal of the American Peptide Society 2005;65(2):175-88.
2005: Nelly Morellet; Sabine Druillennec; Christine Lenoir; Serge Bouaziz; Bernard P Roques
Helical structure determined by NMR of the HIV-1 (345-392)Gag sequence, surrounding p2: implications for particle assembly and RNA packaging.
Protein science : a publication of the Protein Society 2005;14(2):375-86.
2005: Magdalena Mas Nieto; S L E Guen; B L Kieffer; Bernard P Roques; Florence Noble
Physiological control of emotion-related behaviors by endogenous enkephalins involves essentially the delta opioid receptors.
Neuroscience 2005;135(2):305-13.
2005: L Cordonnier; M Sanchez; Bernard P Roques; Florence Noble
Facilitation of enkephalins-induced delta-opioid behavioral responses by chronic amisulpride treatment.
Neuroscience 2005;135(1):1-10.
2004: Cynthia Marie-Claire; Cindie Courtin; Bernard P Roques; Florence Noble
Cytoskeletal genes regulation by chronic morphine treatment in rat striatum.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2004;29(12):2208-15.
2004: Caroline Egelé; Emmanuel Schaub; Nick Ramalanjaona; Etienne Piémont; Damien Ficheux; Bernard P Roques; Jean-Luc Darlix; Yves Mély
HIV-1 nucleocapsid protein binds to the viral DNA initiation sequences and chaperones their kissing interactions.
Journal of molecular biology 2004;342(2):453-66.
2004: Roland H Stote; Esther Kellenberger; Hervé Muller; Elisa Bombarda; Bernard P Roques; Bruno Kieffer; Yves Mély
Structure of the His44 --> Ala single point mutant of the distal finger motif of HIV-1 nucleocapsid protein: a combined NMR, molecular dynamics simulation, and fluorescence study.
Biochemistry 2004;43(24):7687-97.
2004: Stéphanie Ramboarina; Sabine Druillennec; Nelly Morellet; Serge Bouaziz; Bernard P Roques
Target specificity of human immunodeficiency virus type 1 NCp7 requires an intact conformation of its CCHC N-terminal zinc finger.
Journal of virology 2004;78(12):6682-7.
2004: Armand Blommaert; Serge Turcaud; Christine Anne; Bernard P Roques
Small tripeptide surrogates with low nanomolar affinity as potent inhibitors of the botulinum neurotoxin B metallo-proteolytic activity.
Bioorganic & medicinal chemistry 2004;12(11):3055-62.
2004: Marie-Claude Fournie-Zaluski; Celine Fassot; Bruno Valentin; Dragan Djordjijevic; Annabelle Reaux-Le Goazigo; Pierre Corvol; Bernard P Roques; Catherine Llorens-Cortes
Brain renin-angiotensin system blockade by systemically active aminopeptidase A inhibitors: a potential treatment of salt-dependent hypertension.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(20):7775-80.
2004: Hervé Beltz; Etienne Piémont; Emmanuel Schaub; Damien Ficheux; Bernard P Roques; Jean-Luc Darlix; Yves Mély
Role of the structure of the top half of HIV-1 cTAR DNA on the nucleic acid destabilizing activity of the nucleocapsid protein NCp7.
Journal of molecular biology 2004;338(4):711-23.
2004: Fanny Jardinaud; Ghazal Banisadr; Florence Noble; Stéphane Mélik Parsadaniantz; Huixiong Chen; Christophe Dugave; Hervé Laplace; William Rostène; Marie-Claude Fournié-Zaluski; Bernard P Roques; Théodora Popovici
Ontogenic and adult whole body distribution of aminopeptidase N in rat investigated by in vitro autoradiography.
Biochimie 2004;86(2):105-13.
2004: Nicolas Inguimbert; Hervé PORAS; H Dhotel; Françoise Beslot; Elizabeth Scalbert; Caroline Bennejean; Pierre Renard; Marie-Claude Fournié-Zaluski; Bernard P Roques
In vivo properties of thiol inhibitors of the three vasopeptidases NEP, ACE and ECE are improved by introduction of a 7-azatryptophan in P2' position.
The journal of peptide research : official journal of the American Peptide Society 2004;63(2):99-107.
2004: Christian Oefner; Bernard P Roques; Marie-Claude Fournie-Zaluski; Glenn E Dale
Structural analysis of neprilysin with various specific and potent inhibitors.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 2):392-6.
2004: Carine Tisné; Bernard P Roques; Frédéric Dardel
The annealing mechanism of HIV-1 reverse transcription primer onto the viral genome.
The Journal of biological chemistry 2004;279(5):3588-95.
2003: Florence Noble; Bernard P Roques
The role of CCK2 receptors in the homeostasis of the opioid system.
Drugs of today (Barcelona, Spain : 1998) 2003;39(11):897-908.
2003: Julie Salzmann; Cynthia Marie-Claire; Stéphanie Le Guen; Bernard P Roques; Florence Noble
Importance of ERK activation in behavioral and biochemical effects induced by MDMA in mice.
British journal of pharmacology 2003;140(5):831-8.
2003: Christine Anne; Serge Turcaud; Jean Quancard; Franck Teffo; Hervé MEUDAL; Marie-Claude Fournié-Zaluski; Bernard P Roques
Development of potent inhibitors of botulinum neurotoxin type B.
Journal of medicinal chemistry 2003;46(22):4648-56.
2003: Christine Anne; Armand Blommaert; Serge Turcaud; Anne-Sophie Martin; Hervé MEUDAL; Bernard P Roques
Thio-derived disulfides as potent inhibitors of botulinum neurotoxin type B: implications for zinc interaction.
Bioorganic & medicinal chemistry 2003;11(21):4655-60.
2003: Guruswamy Krishnamoorthy; Bernard P Roques; Jean-Luc Darlix; Yves Mély
DNA condensation by the nucleocapsid protein of HIV-1: a mechanism ensuring DNA protection.
Nucleic acids research 2003;31(18):5425-32.
2003: Cynthia Marie-Claire; Ingrid Laurendeau; Corinne Canestrelli; Cindie Courtin; Michel Vidaud; Bernard P Roques; Florence Noble
Fos but not Cart (cocaine and amphetamine regulated transcript) is overexpressed by several drugs of abuse: a comparative study using real-time quantitative polymerase chain reaction in rat brain.
Neuroscience letters 2003;345(2):77-80.
2003: Stéphanie Le Guen; Magdalena Mas Nieto; Corinne Canestrelli; Huixiong Chen; Marie-Claude Fournié-Zaluski; Annie Cupo; Rafael Maldonado; Bernard P Roques; Florence Noble
Pain management by a new series of dual inhibitors of enkephalin degrading enzymes: long lasting antinociceptive properties and potentiation by CCK2 antagonist or methadone.
Pain 2003;104(1-2):139-48.
2003: Mohamed Selkti; Alain Tomas; Jean-François Gaucher; Thierry Prangé; Marie-Claude Fournié-Zaluski; Huixiong Chen; Bernard P Roques
Interactions of a new alpha-aminophosphinic derivative inside the active site of TLN (thermolysin): a model for zinc-metalloendopeptidase inhibition.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 7):1200-5.
2003: Leonora Poljak; Susan M Batson; Damien Ficheux; Bernard P Roques; Jean-Luc Darlix; Emmanuel Käs
Analysis of NCp7-dependent activation of HIV-1 cDNA integration and its conservation among retroviral nucleocapsid proteins.
Journal of molecular biology 2003;329(3):411-21.
2003: Julien Bischerour; Patrick TAUC; Hervé Leh; Hugues de Rocquigny; Bernard P Roques; Jean-François Mouscadet
The (52-96) C-terminal domain of Vpr stimulates HIV-1 IN-mediated homologous strand transfer of mini-viral DNA.
Nucleic acids research 2003;31(10):2694-702.
2003: Carine Tisné; Bernard P Roques; Frédéric Dardel
Specific recognition of primer tRNA Lys 3 by HIV-1 nucleocapsid protein: involvement of the zinc fingers and the N-terminal basic extension.
Biochimie 2003;85(5):557-61.
2003: Bernard P Roques; F Noble
[Plusridisciplinary approaches to understand the neutoxic effects of Ecstasy].
Annales pharmaceutiques françaises 2003;61(3):157-63.
2003: Hervé Beltz; Joel Azoulay; Serena Bernacchi; Jean-Pierre Clamme; Damien Ficheux; Bernard P Roques; Jean-Luc Darlix; Yves Mély
Impact of the terminal bulges of HIV-1 cTAR DNA on its stability and the destabilizing activity of the nucleocapsid protein NCp7.
Journal of molecular biology 2003;328(1):95-108.
2003: Blandine Pommier; Cynthia Marie-Claire; Sophie Da Nascimento; Hung-Li Wang; Bernard P Roques; Florence Noble
Further evidence that the CCK2 receptor is coupled to two transduction pathways using site-directed mutagenesis.
Journal of neurochemistry 2003;85(2):454-61.
2003: Stéphanie Le Guen; Gwénaëlle Catheline; Marie-Claude Fournié-Zaluski; Bernard P Roques; Jean-Marie Besson; Jaroslava Buritova
Further evidence for the interaction of mu- and delta-opioid receptors in the antinociceptive effects of the dual inhibitor of enkephalin catabolism, RB101(S). A spinal c-Fos protein study in the rat under carrageenin inflammation.
Brain research 2003;967(1-2):106-12.
2003: Nelly Morellet; Serge Bouaziz; P Petitjean; Bernard P Roques
NMR structure of the HIV-1 regulatory protein VPR.
Journal of molecular biology 2003;327(1):215-27.
2003: Joel Azoulay; Jean-Pierre Clamme; Jean-Luc Darlix; Bernard P Roques; Yves Mély
Destabilization of the HIV-1 complementary sequence of TAR by the nucleocapsid protein through activation of conformational fluctuations.
Journal of molecular biology 2003;326(3):691-700.
2003: Raphaël Rozenfeld; Annabelle Reaux; Xavier Iturrioz; Celine Fassot; Marie-Claude Fournie-Zaluski; Christelle David; Bernard Maigret; Bernard P Roques; Pierre Corvol; Catherine Llorens-Cortes
Aminopeptidase A, generating one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, plays a key role in central control of blood pressure.
Proceedings of the Western Pharmacology Society 2003;46():39-44.
2003: Jaroslava Buritova; Stéphanie Le Guen; Marie-Claude Fournié-Zaluski; Bernard P Roques; Jean-Marie Besson
Antinociceptive effects of RB101(S), a complete inhibitor of enkephalin-catabolizing enzymes, are enhanced by (+)-HA966, a functional NMDA receptor antagonist: a c-Fos study in the rat spinal cord.
European journal of pain (London, England) 2003;7(3):241-9.
2003: Valérie Daugé; M Pophillat; Dominique Crété; S Melik-Parsadaniantz; Bernard P Roques
Involvement of brain endogenous cholecystokinin in stress-induced impairment of spatial recognition memory.
Neuroscience 2003;118(1):19-23.
2002: Thomas Roumier; Helena L A Vieira; Maria Castedo; Karine F Ferri; Marian Mellen; Karine Andreau; Sabine Druillennec; Nicholas Joza; Josef M Penninger; Bernard P Roques; Guido Kroemer
The C-terminal moiety of HIV-1 Vpr induces cell death via a caspase-independent mitochondrial pathway.
Cell death and differentiation 2002;9(11):1212-9.
2002: Nicolas Inguimbert; Hervé PORAS; Franck Teffo; Françoise Beslot; Mohamed Selkti; Alain Tomas; Elizabeth Scalbert; Caroline Bennejean; Pierre Renard; Marie-Claude Fournié-Zaluski; Bernard P Roques
N-[2-(Indan-1-yl)-3-mercapto-propionyl] amino acids as highly potent inhibitors of the three vasopeptidases (NEP, ACE, ECE): In vitro and In vivo activities.
Bioorganic & medicinal chemistry letters 2002;12(15):2001-5.
2002: K Wecker; Nelly Morellet; Serge Bouaziz; Bernard P Roques
NMR structure of the HIV-1 regulatory protein Vpr in H2O/trifluoroethanol. Comparison with the Vpr N-terminal (1-51) and C-terminal (52-96) domains.
European journal of biochemistry / FEBS 2002;269(15):3779-88.
2002: Maria Castedo; Thomas Roumier; Julià Blanco; Karine F Ferri; Jordi Barretina; lionel tintignac; Karine Andreau; Jean-Luc PERFETTINI; Alessandra Amendola; Roberta Nardacci; Philip Leduc; Donald Ingber; Sabine Druillennec; Bernard P Roques; Serge Leibovitch; Montserrat Vilella-Bach; Jie Chen; José A Este; Nazanine Modjtahedi; Mauro Piacentini; Guido Kroemer
Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope.
The EMBO journal 2002;21(15):4070-80.
2002: Stéphanie Le Guen; Florence Noble; Marie-Claude Fournié-Zaluski; Bernard P Roques; Jean-Marie Besson; Jaroslava Buritova
RB101(S), a dual inhibitor of enkephalinases does not induce antinociceptive tolerance, or cross-tolerance with morphine: a c-Fos study at the spinal level.
European journal of pharmacology 2002;441(3):141-50.
2002: Vaea Richard de Soultrait; Anne Caumont; Vincent Parissi; Nelly Morellet; Michel Ventura; Christine Lenoir; Simon Litvak; Michel Fournier; Bernard P Roques
A novel short peptide is a specific inhibitor of the human immunodeficiency virus type 1 integrase.
Journal of molecular biology 2002;318(1):45-58.
2002: Elisa Bombarda; H Cherradi; Nelly Morellet; Bernard P Roques; Yves Mély
Zn(2+) binding properties of single-point mutants of the C-terminal zinc finger of the HIV-1 nucleocapsid protein: evidence of a critical role of cysteine 49 in Zn(2+) dissociation.
Biochemistry 2002;41(13):4312-20.
2002: Florence Noble; Bernard P Roques
Phenotypes of mice with invalidation of cholecystokinin (CCK(1) or CCK(2)) receptors.
Neuropeptides 2002;36(2-3):157-70.
2002: Serena Bernacchi; Stoyl Stoylov; Etienne Piémont; Damien Ficheux; Bernard P Roques; Jean-Luc Darlix; Yves Mély
HIV-1 nucleocapsid protein activates transient melting of least stable parts of the secondary structure of TAR and its complementary sequence.
Journal of molecular biology 2002;317(3):385-99.
2002: Nicolas Inguimbert; Pascale Coric; Hervé PORAS; Hervé MEUDAL; Franck Teffot; Marie-Claude Fournié-Zaluski; Bernard P Roques
Toward an optimal joint recognition of the S1' subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase (NEP).
Journal of medicinal chemistry 2002;45(7):1477-86.
2002: Helena L A Vieira; Marian Mellen; Isabelle Cohen; Chahrazed El Hamel; Delphine Haouzi; Sabine Druillenec; Anne-Sophie Belzacq; catherine brenner; Bernard P Roques; Guido Kroemer
Cell permeable BH3-peptides overcome the cytoprotective effect of Bcl-2 and Bcl-X(L).
Oncogene 2002;21(13):1963-77.
2002: Blandine Pommier; Françoise Beslot; Axelle Simon; Matthieu Pophillat; Toshimitsu Matsui; Valérie Dauge; Bernard P Roques; Florence Noble
Deletion of CCK2 receptor in mice results in an upregulation of the endogenous opioid system.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(5):2005-11.
2002: Stéphanie Ramboarina; Narayanan Srividya; R Andrew Atkinson; Nelly Morellet; Bernard P Roques; Jean-François Lefèvre; Yves Mély; Bruno Kieffer
Effects of temperature on the dynamic behaviour of the HIV-1 nucleocapsid NCp7 and its DNA complex.
Journal of molecular biology 2002;316(3):611-27.
2002: Pierre Nioche; Wang-Qing Liu; Isabelle Broutin; Franck Charbonnier; Marie-Thérèse Latreille; Michel Vidal; Bernard P Roques; Christiane Garbay; Arnaud Ducruix
Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor.
Journal of molecular biology 2002;315(5):1167-77.
2002: Magdalena Mas Nieto; Jodie Wilson; Annie Cupo; Bernard P Roques; Florence Noble
Chronic morphine treatment modulates the extracellular levels of endogenous enkephalins in rat brain structures involved in opiate dependence: a microdialysis study.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(3):1034-41.
2001: Liwei Rong; Chen Liang; M Hsu; Xiaofeng Guo; Bernard P Roques; Mark A Wainberg
HIV-1 nucleocapsid protein and the secondary structure of the binary complex formed between tRNA(Lys.3) and viral RNA template play different roles during initiation of (-) strand DNA reverse transcription.
The Journal of biological chemistry 2001;276(50):47725-32.
2001: Valérie Daugé; A Sebret; Françoise Beslot; Toshimitsu Matsui; Bernard P Roques
Behavioral profile of CCK2 receptor-deficient mice.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2001;25(5):690-8.
2001: Huixiong Chen; Florence Noble; Bernard P Roques; Marie-Claude Fournié-Zaluski
Long lasting antinociceptive properties of enkephalin degrading enzyme (NEP and APN) inhibitor prodrugs.
Journal of medicinal chemistry 2001;44(21):3523-30.
2001: Magdalena Mas Nieto; J Wilson; J Walker; J Benavides; Marie-Claude Fournié-Zaluski; Bernard P Roques; Florence Noble
Facilitation of enkephalins catabolism inhibitor-induced antinociception by drugs classically used in pain management.
Neuropharmacology 2001;41(4):496-506.
2001: Marian Mellen; Bernard P Roques; Guido Kroemer
New EMBO members' review: viral and bacterial proteins regulating apoptosis at the mitochondrial level.
The EMBO journal 2001;20(16):4325-31.
2001: Elisa Bombarda; Nelly Morellet; H Cherradi; Bernard Spiess; Serge Bouaziz; Ernst Grell; Bernard P Roques; Yves Mély
Determination of the pK(a) of the four Zn2+-coordinating residues of the distal finger motif of the HIV-1 nucleocapsid protein: consequences on the binding of Zn2+.
Journal of molecular biology 2001;310(3):659-72.
2001: Valérie Daugé; Françoise Beslot; Toshimitsu Matsui; Bernard P Roques
Mutant mice lacking the cholecystokinin2 receptor show a dopamine-dependent hyperactivity and a behavioral sensitization to morphine.
Neuroscience letters 2001;306(1-2):41-4.
2001: N Luciani; Hugues de Rocquigny; Serge Turcaud; A Romieu; Bernard P Roques
Highly sensitive and selective fluorescence assays for rapid screening of endothelin-converting enzyme inhibitors.
The Biochemical journal 2001;356(Pt 3):813-9.
2001: O Valverde; Florence Noble; Françoise Beslot; Valérie Daugé; Marie-Claude Fournié-Zaluski; Bernard P Roques
Delta9-tetrahydrocannabinol releases and facilitates the effects of endogenous enkephalins: reduction in morphine withdrawal syndrome without change in rewarding effect.
The European journal of neuroscience 2001;13(9):1816-24.
2001: Christine Anne; F Cornille; Christine Lenoir; Bernard P Roques
High-throughput fluorogenic assay for determination of botulinum type B neurotoxin protease activity.
Analytical biochemistry 2001;291(2):253-61.
2001: M Mas-Nieto; Blandine Pommier; Eleni T Tzavara; A Caneparo; Sophie Da Nascimento; G Le Fur; Bernard P Roques; Florence Noble
Reduction of opioid dependence by the CB(1) antagonist SR141716A in mice: evaluation of the interest in pharmacotherapy of opioid addiction.
British journal of pharmacology 2001;132(8):1809-16.
2001: Carine Tisné; Bernard P Roques; Frédéric Dardel
Heteronuclear NMR studies of the interaction of tRNA(Lys)3 with HIV-1 nucleocapsid protein.
Journal of molecular biology 2001;306(3):443-54.
2001: Etienne Jacotot; Karine F Ferri; Chahrazed El Hamel; catherine brenner; Sabine Druillennec; J Hoebeke; Pierre Rustin; Didier Métivier; Christine Lenoir; M Geuskens; Helena L A Vieira; M Loeffler; Anne-Sophie Belzacq; Jean-Paul Briand; Naoufal Zamzami; Léna Edelman; ZH Xie; JC Reed; Bernard P Roques; Guido Kroemer
Control of mitochondrial membrane permeabilization by adenine nucleotide translocator interacting with HIV-1 viral protein rR and Bcl-2.
The Journal of experimental medicine 2001;193(4):509-19.
2001: Eliane Boudinot; Marie-Pierre Morin-Surun; Arthur S Foutz; M Fournié-Zaluski; Bernard P Roques; Monique Denavit-Saubié
Effects of the potent analgesic enkephalin-catabolizing enzyme inhibitors RB101 and kelatorphan on respiration.
Pain 2001;90(1-2):7-13.
2001: Florence Noble; Ghazal Banisadr; Fanny Jardinaud; T Popovici; R Lai-Kuen; Huixiong Chen; L Bischoff; Stéphane Mélik Parsadaniantz; MC Fournie-Zaluski; Bernard P Roques
First discrete autoradiographic distribution of aminopeptidase N in various structures of rat brain and spinal cord using the selective iodinated inhibitor [125I]RB 129.
Neuroscience 2001;105(2):479-88.
2000: Bernard P Roques
Novel approaches to targeting neuropeptide systems.
Trends in pharmacological sciences 2000;21(12):475-83.
2000: Christiane Garbay; Wang-Qing Liu; Michel Vidal; Bernard P Roques
Inhibitors of Ras signal transduction as antitumor agents.
Biochemical pharmacology 2000;60(8):1165-9.
2000: Bernard P Roques; Christine Anne; Serge Turcaud; Marie-Claude Fournié-Zaluski
Mechanism of action of clostridial neurotoxins and rational inhibitor design.
Biology of the cell / under the auspices of the European Cell Biology Organization 2000;92(6):445-7.
2000: Hugues de Rocquigny; A Caneparo; CZ Dong; T Delaunay; Bernard P Roques
Generation of monoclonal antibodies specifically directed against the proximal zinc finger of HIV type 1 NCp7.
AIDS research and human retroviruses 2000;16(13):1259-67.
2000: J A Bousquet; C Garbay; Bernard P Roques; Yves Mély
Circular dichroic investigation of the native and non-native conformational states of the growth factor receptor-binding protein 2 N-terminal src homology domain 3: effect of binding to a proline-rich peptide from guanine nucleotide exchange factor.
Biochemistry 2000;39(26):7722-35.
2000: Florence Noble; M Szücs; B Kieffer; Bernard P Roques
Overexpression of dynamin is induced by chronic stimulation of mu- but not delta-opioid receptors: relationships with mu-related morphine dependence.
Molecular pharmacology 2000;58(1):159-66.
2000: Hugues de Rocquigny; A Caneparo; T Delaunay; Julien Bischerour; Jean-François Mouscadet; Bernard P Roques
Interactions of the C-terminus of viral protein R with nucleic acids are modulated by its N-terminus.
European journal of biochemistry / FEBS 2000;267(12):3654-60.
2000: Antoine Kichler; J C Pages; Christian Leborgne; Sabine Druillennec; Christine Lenoir; Dominique Coulaud; Etienne Delain; Eric Le Cam; Bernard P Roques; Olivier Danos
Efficient DNA transfection mediated by the C-terminal domain of human immunodeficiency virus type 1 viral protein R.
Journal of virology 2000;74(12):5424-31.
2000: Cynthia Marie-Claire; G Tiraboschi; E Ruffet; N Inguimbert; MC Fournie-Zaluski; Bernard P Roques
Exploration of the S(')(1) subsite of neprilysin: a joined molecular modeling and site-directed mutagenesis study.
Proteins 2000;39(4):365-71.
2000: M Hsu; Liwei Rong; Hugues de Rocquigny; Bernard P Roques; Mark A Wainberg
The effect of mutations in the HIV-1 nucleocapsid protein on strand transfer in cell-free reverse transcription reactions.
Nucleic acids research 2000;28(8):1724-9.
2000: Huixiong Chen; Florence Noble; A Mothé; Hervé MEUDAL; Pascale Coric; S Danascimento; Bernard P Roques; Pascal Guy GEORGE; Marie-Claude Fournié-Zaluski
Phosphinic derivatives as new dual enkephalin-degrading enzyme inhibitors: synthesis, biological properties, and antinociceptive activities.
Journal of medicinal chemistry 2000;43(7):1398-408.
2000: KS Gajiwala; H Chen; F Cornille; Bernard P Roques; W Reith; B Mach; Stephen K Burley
Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding.
Nature 2000;403(6772):916-21.
2000: Florence Noble; N Luciani; Sophie Da Nascimento; R Laï-Kuen; L Bischoff; Huixiong Chen; Marie-Claude Fournié-Zaluski; Bernard P Roques
Binding properties of a highly potent and selective iodinated aminopeptidase N inhibitor appropriate for radioautography.
FEBS letters 2000;467(1):81-6.
2000: O Valverde; C Ledent; Françoise Beslot; M Parmentier; Bernard P Roques
Reduction of stress-induced analgesia but not of exogenous opioid effects in mice lacking CB1 receptors.
The European journal of neuroscience 2000;12(2):533-9.
2000: Etienne Jacotot; Luigi Ravagnan; M Loeffler; Karine F Ferri; Helena L A Vieira; Naoufal Zamzami; P Costantini; Sabine Druillennec; J Hoebeke; Jean-Paul Briand; T Irinopoulou; Eric Daugas; Santos A Susin; D Cointe; ZH Xie; JC Reed; Bernard P Roques; Guido Kroemer
The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore.
The Journal of experimental medicine 2000;191(1):33-46.
2000: Annabelle Reaux; Xavier Iturrioz; Gilles Vazeux; Marie-Claude Fournie-Zaluski; Christelle David; Bernard P Roques; Pierre Corvol; Catherine Llorens-Cortes
Aminopeptidase A, which generates one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, has a key role in central control of arterial blood pressure.
Biochemical Society transactions 2000;28(4):435-40.
1999: C Vuilleumier; Elisa Bombarda; Nelly Morellet; Dominique Gérard; Bernard P Roques; Yves Mély
Nucleic acid sequence discrimination by the HIV-1 nucleocapsid protein NCp7: a fluorescence study.
Biochemistry 1999;38(51):16816-25.
1999: C David; L Bischoff; Hervé MEUDAL; A Mothé; Nadia De Mota; S Danascimento; Catherine Llorens-Cortes; Marie-Claude Fournié-Zaluski; Bernard P Roques
Investigation of subsite preferences in aminopeptidase A (EC 3.4.11.7) led to the design of the first highly potent and selective inhibitors of this enzyme.
Journal of medicinal chemistry 1999;42(25):5197-211.
1999: Florence Noble; Stephen A Wank; Jacqueline N Crawley; J Bradwejn; K B Seroogy; Michel Hamon; Bernard P Roques
International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin receptors.
Pharmacological reviews 1999;51(4):745-81.
1999: Annabelle Reaux; Marie-Claude Fournie-Zaluski; Christelle David; S Zini; Bernard P Roques; Pierre Corvol; Catherine Llorens-Cortes
Aminopeptidase A inhibitors as potential central antihypertensive agents.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(23):13415-20.
1999: F Cornille; K Wecker; A Loffet; R Genet; Bernard P Roques
Efficient solid-phase synthesis of Vpr from HIV-1 using low quantities of uniformly 13C-, 15N-labeled amino acids for NMR structural studies.
The journal of peptide research : official journal of the American Peptide Society 1999;54(5):427-35.
1999: D M Hutcheson; P Sánchez-Blazquez; M Rodriguez-Diaz; J Garzon; Helmut Schmidhammer; Anna Borsodi; Bernard P Roques; Rafael Maldonado
Use of selective antagonists and antisense oligonucleotides to evaluate the mechanisms of BUBU antinociception.
European journal of pharmacology 1999;383(1):29-37.
1999: W Schüler; C Dong; K Wecker; Bernard P Roques
NMR structure of the complex between the zinc finger protein NCp10 of Moloney murine leukemia virus and the single-stranded pentanucleotide d(ACGCC): comparison with HIV-NCp7 complexes.
Biochemistry 1999;38(40):12984-94.
1999: Jean-François Gaucher; Mohamed Selkti; G Tiraboschi; Thierry Prangé; Bernard P Roques; Alain Tomas; Marie-Claude Fournié-Zaluski
Crystal structures of alpha-mercaptoacyldipeptides in the thermolysin active site: structural parameters for a Zn monodentation or bidentation in metalloendopeptidases.
Biochemistry 1999;38(39):12569-76.
1999: Wang-Qing Liu; Michel Vidal; Nohad Gresh; Bernard P Roques; Christiane Garbay
Small peptides containing phosphotyrosine and adjacent alphaMe-phosphotyrosine or its mimetics as highly potent inhibitors of Grb2 SH2 domain.
Journal of medicinal chemistry 1999;42(18):3737-41.
1999: Annette Hus-Citharel; J M Gasc; S Zini; Jeannine Marchetti; Bernard P Roques; Pierre Corvol; Catherine Llorens-Cortes
Aminopeptidase A activity and angiotensin III effects on [Ca2+]i along the rat nephron.
Kidney international 1999;56(3):850-9.
1999: A Sebret; Isabelle Léna; Dominique Crété; Toshimitsu Matsui; Bernard P Roques; Valérie Daugé
Rat hippocampal neurons are critically involved in physiological improvement of memory processes induced by cholecystokinin-B receptor stimulation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(16):7230-7.
1999: Stéphanie Ramboarina; Nelly Morellet; Marie-Claude Fournié-Zaluski; Bernard P Roques; N Moreller
Structural investigation on the requirement of CCHH zinc finger type in nucleocapsid protein of human immunodeficiency virus 1.
Biochemistry 1999;38(30):9600-7.
1999: Stéphanie Le Guen; P Honoré; Gwénaëlle Catheline; Marie-Claude Fournié-Zaluski; Bernard P Roques; Jean-Marie Besson
The effects of RB101, a mixed inhibitor of enkephalin-catabolizing enzymes, on carrageenin-induced spinal c-Fos expression are completely blocked by beta-funaltrexamine, a selective mu-opioid receptor antagonist.
Brain research 1999;834(1-2):200-6.
1999: Valérie Daugé; A Samir; Annie Cupo; Bernard P Roques
Peripheral stimulation of CCK-B receptors by BC264 induces a hyperexploration, dependent on the delta opioid system in the nucleus accumbens of rat.
Neuropharmacology 1999;38(7):999-1007.
1999: Blandine Pommier; Sophie Da Nascimento; S Dumont; Bruno Bellier; E Million; Christiane Garbay; Bernard P Roques; Florence Noble
The cholecystokininB receptor is coupled to two effector pathways through pertussis toxin-sensitive and -insensitive G proteins.
Journal of neurochemistry 1999;73(1):281-8.
1999: Florence Noble; Bernard P Roques
CCK-B receptor: chemistry, molecular biology, biochemistry and pharmacology.
Progress in neurobiology 1999;58(4):349-79.
1999: Huixiong Chen; Bernard P Roques; Marie-Claude Fournié-Zaluski
Design of the first highly potent and selective aminopeptidase N (EC 3.4.11.2) inhibitor.
Bioorganic & medicinal chemistry letters 1999;9(11):1511-6.
1999: A Réaux; Nadia De Mota; S Zini; Sandrine Cadel; Marie-Claude Fournié-Zaluski; Bernard P Roques; Pierre Corvol; Catherine Llorens-Cortès
PC18, a specific aminopeptidase N inhibitor, induces vasopressin release by increasing the half-life of brain angiotensin III.
Neuroendocrinology 1999;69(5):370-6.
1999: S Druillennec; CZ Dong; S Escaich; Nohad Gresh; A Bousseau; Bernard P Roques; Marie-Claude Fournié-Zaluski
A mimic of HIV-1 nucleocapsid protein impairs reverse transcription and displays antiviral activity.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(9):4886-91.
1999: S Druillennec; A Caneparo; Hugues de Rocquigny; Bernard P Roques
Evidence of interactions between the nucleocapsid protein NCp7 and the reverse transcriptase of HIV-1.
The Journal of biological chemistry 1999;274(16):11283-8.
1999: K Taghzouti; Isabelle Léna; F Dellu; Bernard P Roques; Valérie Daugé; Hervé Simon
Cognitive enhancing effects in young and old rats of pBC264, a selective CCK(B) receptor agonist.
Psychopharmacology 1999;143(2):141-9.
1999: Isabelle Léna; Hervé Simon; Bernard P Roques; Valérie Daugé
Opposing effects of two CCK(B) agonists on the retrieval phase of a two-trial memory task after systemic injection in the rat.
Neuropharmacology 1999;38(4):543-53.
1999: Elisa Bombarda; A Ababou; C Vuilleumier; Dominique Gérard; Bernard P Roques; Etienne Piémont; Yves Mély
Time-resolved fluorescence investigation of the human immunodeficiency virus type 1 nucleocapsid protein: influence of the binding of nucleic acids.
Biophysical journal 1999;76(3):1561-70.
1999: S Druillennec; Hervé MEUDAL; Bernard P Roques; Marie-Claude Fournié-Zaluski
Nucleomimetic strategy for the inhibition of HIV-1 nucleocapsid protein NCp7 activities.
Bioorganic & medicinal chemistry letters 1999;9(4):627-32.
1999: Loic MARTIN; F Cornille; Serge Turcaud; Hervé MEUDAL; Bernard P Roques; Marie-Claude Fournié-Zaluski
Metallopeptidase inhibitors of tetanus toxin: A combinatorial approach.
Journal of medicinal chemistry 1999;42(3):515-25.
1999: W Schüler; K Wecker; H de Rocquigny; Y Baudat; Joséphine Sire; Bernard P Roques
NMR structure of the (52-96) C-terminal domain of the HIV-1 regulatory protein Vpr: molecular insights into its biological functions.
Journal of molecular biology 1999;285(5):2105-17.
1999: Cynthia Marie-Claire; E Ruffet; A Beaumont; Bernard P Roques
The prosequence of thermolysin acts as an intramolecular chaperone when expressed in trans with the mature sequence in Escherichia coli.
Journal of molecular biology 1999;285(5):1911-5.
1999: G Tiraboschi; N Jullian; V Thery; S Antonczak; MC Fournie-Zaluski; Bernard P Roques
A three-dimensional construction of the active site (region 507-749) of human neutral endopeptidase (EC.3.4.24.11).
Protein engineering 1999;12(2):141-9.
1999: C Ledent; O Valverde; Gregorio Cossu; François Petitet; Jean-François Aubert; Françoise Beslot; Georg Andrees Bohme; Assunta Imperato; T Pedrazzini; Bernard P Roques; G Vassart; Walter Fratta; M Parmentier
Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice.
Science (New York, N.Y.) 1999;283(5400):401-4.
1999: N Khelifa; M Brik; AC Tessedre; Hugues de Rocquigny; Bernard P Roques; J Courtieu; A Rimbault
Cleavage of L-leucine-containing dipeptides by Clostridium butyricum.
Bioorganic & medicinal chemistry letters 1999;9(1):109-12.
1999: Florence Noble; Marie-Claude Fournié-Zaluski; Bernard P Roques
[Enkephalin catabolism inhibitors and antalgics of the future: from preclinical research to clinical trials].
Thérapie 1999;54(1):121-33.
1999: D Cussac; Michel Vidal; corinne leprince; Wang-Qing Liu; F Cornille; G Tiraboschi; Bernard P Roques; Christiane Garbay
A Sos-derived peptidimer blocks the Ras signaling pathway by binding both Grb2 SH3 domains and displays antiproliferative activity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1999;13(1):31-8.
1998: Daniela Lener; V Tanchou; Bernard P Roques; Stuart F J Le Grice; Jean-Luc Darlix
Involvement of HIV-I nucleocapsid protein in the recruitment of reverse transcriptase into nucleoprotein complexes formed in vitro.
The Journal of biological chemistry 1998;273(50):33781-6.
1998: D M Hutcheson; Eleni T Tzavara; C Smadja; Emmanuel Valjent; Bernard P Roques; Jacques Hanoune; Rafael Maldonado
Behavioural and biochemical evidence for signs of abstinence in mice chronically treated with delta-9-tetrahydrocannabinol.
British journal of pharmacology 1998;125(7):1567-77.
1998: Liwei Rong; Chen Liang; M Hsu; Lawrence Kleiman; P Petitjean; Hugues de Rocquigny; Bernard P Roques; Mark A Wainberg
Roles of the human immunodeficiency virus type 1 nucleocapsid protein in annealing and initiation versus elongation in reverse transcription of viral negative-strand strong-stop DNA.
Journal of virology 1998;72(11):9353-8.
1998: Nelly Morellet; H Déméné; V Teilleux; T Huynh-Dinh; Hugues de Rocquigny; Marie-Claude Fournié-Zaluski; Bernard P Roques
Structure of the complex between the HIV-1 nucleocapsid protein NCp7 and the single-stranded pentanucleotide d(ACGCC).
Journal of molecular biology 1998;283(2):419-34.
1998: Huixiong Chen; Florence Noble; Pascale Coric; MC Fournie-Zaluski; Bernard P Roques
Aminophosphinic inhibitors as transition state analogues of enkephalin-degrading enzymes: a class of central analgesics.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(20):12028-33.
1998: H W D Matthes; C Smadja; O Valverde; Jean-Luc Vonesch; Arthur S Foutz; Eliane Boudinot; Monique Denavit-Saubié; Cinzia Severini; Lucia Negri; Bernard P Roques; Rafael Maldonado; Jerome Becker
Activity of the delta-opioid receptor is partially reduced, whereas activity of the kappa-receptor is maintained in mice lacking the mu-receptor.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(18):7285-95.
1998: Antonio Ortega-Alvaro; Anjo J Chover-Gonzalez; R Lai-Kuen; Juan Mico; Juan Gibert-Rahola; Marie-Claude Fournié-Zaluski; Bernard P Roques; Rafael Maldonado
Antinociception produced by the peptidase inhibitor, RB 101, in rats with adrenal medullary transplant into the spinal cord.
European journal of pharmacology 1998;356(2-3):139-48.
1998: Stéphanie Ramboarina; Nelly Morellet; P Petitjean; Bernard P Roques; Marie-Claude Fournié-Zaluski
Model of the complex formed between the H2 domain of the TATA box binding protein and the L(281-301) fragment of the human transcription factor TFIIA.
Protein engineering 1998;11(9):729-38.
1998: Loic MARTIN; F Cornille; Pascale Coric; Bernard P Roques; Marie-Claude Fournié-Zaluski
Beta-amino-thiols inhibit the zinc metallopeptidase activity of tetanus toxin light chain.
Journal of medicinal chemistry 1998;41(18):3450-60.
1998: N Ladurelle; A Sebret; Christiane Garbay; Bernard P Roques; Valérie Daugé
Opposite effects of CCK(B) agonists in grooming behaviour in rats: further evidence for two CCK(B) subsites.
British journal of pharmacology 1998;124(6):1091-8.
1998: Bruno Bellier; Sophie Da Nascimento; Hervé MEUDAL; E Gincel; Bernard P Roques; Christiane Garbay
Novel constrained CCK-B dipeptoid antagonists derived from pipecolic acid.
Bioorganic & medicinal chemistry letters 1998;8(11):1419-24.
1998: A Jagerschmidt; N Guillaume; Bernard P Roques; Florence Noble
Binding sites and transduction process of the cholecystokininB receptor: involvement of highly conserved aromatic residues of the transmembrane domains evidenced by site-directed mutagenesis.
Molecular pharmacology 1998;53(5):878-85.
1998: F Cornille; P Emery; W Schüler; Christine Lenoir; B Mach; Bernard P Roques; W Reith
DNA binding properties of a chemically synthesized DNA binding domain of hRFX1.
Nucleic acids research 1998;26(9):2143-9.
1998: B Allain; J B Rascle; Hugues de Rocquigny; Bernard P Roques; Jean-Luc Darlix
CIS elements and trans-acting factors required for minus strand DNA transfer during reverse transcription of the genomic RNA of murine leukemia virus.
Journal of molecular biology 1998;277(2):225-35.
1998: O Valverde; Bernard P Roques
Cholecystokinin modulates the aversive component of morphine withdrawal syndrome in rats.
Neuroscience letters 1998;244(1):37-40.
1998: Cynthia Marie-Claire; Bernard P Roques; A Beaumont
Intramolecular processing of prothermolysin.
The Journal of biological chemistry 1998;273(10):5697-701.
1998: Eric Le Cam; Dominique Coulaud; Etienne Delain; P Petitjean; Bernard P Roques; Dominique Gérard; E Stoylova; C Vuilleumier; Stoyl Stoylov; Yves Mély
Properties and growth mechanism of the ordered aggregation of a model RNA by the HIV-1 nucleocapsid protein: an electron microscopy investigation.
Biopolymers 1998;45(3):217-29.
1998: Michel Vidal; J L Montiel; D Cussac; F Cornille; Marc Duchesne; F Parker; B Tocqué; Bernard P Roques; Christiane Garbay
Differential interactions of the growth factor receptor-bound protein 2 N-SH3 domain with son of sevenless and dynamin. Potential role in the Ras-dependent signaling pathway.
The Journal of biological chemistry 1998;273(9):5343-8.
1998: E Remy; Hugues de Rocquigny; P Petitjean; D Muriaux; V Theilleux; J Paoletti; Bernard P Roques
The annealing of tRNA3Lys to human immunodeficiency virus type 1 primer binding site is critically dependent on the NCp7 zinc fingers structure.
The Journal of biological chemistry 1998;273(9):4819-22.
1998: Frédéric Simonin; O Valverde; C Smadja; Susan Slowe; Ian Kitchen; Andrée Dierich; Marianne Le Meur; Bernard P Roques; Rafael Maldonado; Jerome Becker
Disruption of the kappa-opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective kappa-agonist U-50,488H and attenuates morphine withdrawal.
The EMBO journal 1998;17(4):886-97.
1998: N Luciani; Cynthia Marie-Claire; E Ruffet; A Beaumont; Bernard P Roques; Marie-Claude Fournié-Zaluski
Characterization of Glu350 as a critical residue involved in the N-terminal amine binding site of aminopeptidase N (EC 3.4.11.2): insights into its mechanism of action.
Biochemistry 1998;37(2):686-92.
1997: Hugues de Rocquigny; P Petitjean; V Tanchou; Didier Decimo; L Drouot; T Delaunay; Jean-Luc Darlix; Bernard P Roques
The zinc fingers of HIV nucleocapsid protein NCp7 direct interactions with the viral regulatory protein Vpr.
The Journal of biological chemistry 1997;272(49):30753-9.
1997: Florence Noble; C Smadja; O Valverde; Rafael Maldonado; Pascale Coric; Serge Turcaud; Marie-Claude Fournié-Zaluski; Bernard P Roques
Pain-suppressive effects on various nociceptive stimuli (thermal, chemical, electrical and inflammatory) of the first orally active enkephalin-metabolizing enzyme inhibitor RB 120.
Pain 1997;73(3):383-91.
1997: Bruno Bellier; I McCort-Tranchepain; B Ducos; S Danascimento; Hervé MEUDAL; Florence Noble; Christiane Garbay; Bernard P Roques
Synthesis and biological properties of new constrained CCK-B antagonists: discrimination of two affinity states of the CCK-B receptor on transfected CHO cells.
Journal of medicinal chemistry 1997;40(24):3947-56.
1997: Cynthia Marie-Claire; E Ruffet; S Antonczak; A Beaumont; M O'Donohue; Bernard P Roques; Marie-Claude Fournié-Zaluski
Evidence by site-directed mutagenesis that arginine 203 of thermolysin and arginine 717 of neprilysin (neutral endopeptidase) play equivalent critical roles in substrate hydrolysis and inhibitor binding.
Biochemistry 1997;36(45):13938-45.
1997: Bernard P Roques; Nelly Morellet; Hugues de Rocquigny; H Déméné; W Schueler; N Jullian
Structure, biological functions and inhibition of the HIV-1 proteins Vpr and NCp7.
Biochimie 1997;79(11):673-80.
1997: CZ Dong; Hugues de Rocquigny; E Rémy; S Mellac; Marie-Claude Fournié-Zaluski; Bernard P Roques
Synthesis and biological activities of fluorescent acridine-containing HIV-1 nucleocapsid proteins for investigation of nucleic acid-NCp7 interactions.
The journal of peptide research : official journal of the American Peptide Society 1997;50(4):269-78.
1997: N Ladurelle; G Keller; Armand Blommaert; Bernard P Roques; Valérie Daugé
The CCK-B agonist, BC264, increases dopamine in the nucleus accumbens and facilitates motivation and attention after intraperitoneal injection in rats.
The European journal of neuroscience 1997;9(9):1804-14.
1997: E Bertrand; C Smadja; A Mauborgne; Bernard P Roques; Valérie Daugé
Social interaction increases the extracellular levels of [Met]enkephalin in the nucleus accumbens of control but not of chronic mild stressed rats.
Neuroscience 1997;80(1):17-20.
1997: Rafael Maldonado; Adolfo Saiardi; O Valverde; Tarek A Samad; Bernard P Roques; Emiliana Borrelli
Absence of opiate rewarding effects in mice lacking dopamine D2 receptors.
Nature 1997;388(6642):586-9.
1997: C Smadja; F Ruiz; Pascale Coric; Marie-Claude Fournié-Zaluski; Bernard P Roques; Rafael Maldonado
CCK-B receptors in the limbic system modulate the antidepressant-like effects induced by endogenous enkephalins.
Psychopharmacology 1997;132(3):227-36.
1997: S Carteau; S C Batson; Leonora Poljak; Jean-François Mouscadet; Hugues de Rocquigny; Jean-Luc Darlix; Bernard P Roques; Emmanuel Käs; Christian Auclair
Human immunodeficiency virus type 1 nucleocapsid protein specifically stimulates Mg2+-dependent DNA integration in vitro.
Journal of virology 1997;71(8):6225-9.
1997: S Zini; P Masdehors; Zsolt Lenkei; Marie-Claude Fournie-Zaluski; Bernard P Roques; Pierre Corvol; Catherine Llorens-Cortes
Aminopeptidase A: distribution in rat brain nuclei and increased activity in spontaneously hypertensive rats.
Neuroscience 1997;78(4):1187-93.
1997: O Valverde; C Smadja; Bernard P Roques; Rafael Maldonado
The attenuation of morphine-conditioned place preference following chronic mild stress is reversed by a CCKB receptor antagonist.
Psychopharmacology 1997;131(1):79-85.
1997: P Honore; Jaroslava Buritova; Marie-Claude Fournié-Zaluski; Bernard P Roques; Jean-Marie Besson
Antinociceptive effects of RB101, a complete inhibitor of enkephalin-catabolizing enzymes, are enhanced by a cholecystokinin type B receptor antagonist, as revealed by noxiously evoked spinal c-Fos expression in rats.
The Journal of pharmacology and experimental therapeutics 1997;281(1):208-17.
1997: Stoyl Stoylov; C Vuilleumier; E Stoylova; Hugues de Rocquigny; Bernard P Roques; Dominique Gérard; Yves Mély
Ordered aggregation of ribonucleic acids by the human immunodeficiency virus type 1 nucleocapsid protein.
Biopolymers 1997;41(3):301-12.
1997: Armand Blommaert; H Dhôtel; B Ducos; C Durieux; N Goudreau; André Bado; Christiane Garbay; Bernard P Roques
Structure-based design of new constrained cyclic agonists of the cholecystokinin CCK-B receptor.
Journal of medicinal chemistry 1997;40(5):647-58.
1997: F Cornille; Loic MARTIN; Christine Lenoir; D Cussac; Bernard P Roques; MC Fournie-Zaluski
Cooperative exosite-dependent cleavage of synaptobrevin by tetanus toxin light chain.
The Journal of biological chemistry 1997;272(6):3459-64.
1997: Florence Noble; Bernard P Roques
Association of aminopeptidase N and endopeptidase 24.15 inhibitors potentiate behavioral effects mediated by nociceptin/orphanin FQ in mice.
FEBS letters 1997;401(2-3):227-9.
1997: J L Montiel; F Cornille; Bernard P Roques; Florence Noble
Nociceptin/orphanin FQ metabolism: role of aminopeptidase and endopeptidase 24.15.
Journal of neurochemistry 1997;68(1):354-61.
1997: Isabelle Léna; Bernard P Roques; C Durieux
Dual modulation of dopamine release from anterior nucleus accumbens through cholecystokinin-B receptor subsites.
Journal of neurochemistry 1997;68(1):162-8.
1996: D Muriaux; Hugues de Rocquigny; Bernard P Roques; J Paoletti
NCp7 activates HIV-1Lai RNA dimerization by converting a transient loop-loop complex into a stable dimer.
The Journal of biological chemistry 1996;271(52):33686-92.
1996: O Valverde; Eleni T Tzavara; Jacques Hanoune; Bernard P Roques; Rafael Maldonado
Protein kinases in the rat nucleus accumbens are involved in the aversive component of opiate withdrawal.
The European journal of neuroscience 1996;8(12):2671-8.
1996: Florence Noble; MC Fournie-Zaluski; Bernard P Roques
Opposite role of delta 1- and delta 2-opioid receptors activated by endogenous or exogenous opioid agonists on the endogenous cholecystokinin system: further evidence for delta-opioid receptor heterogeneity.
Neuroscience 1996;75(3):917-26.
1996: M J Blanco-Príeto; C Durieux; Valérie Daugé; Elias Fattal; P Couvreur; Bernard P Roques
Slow delivery of the selective cholecystokinin agonist pBC 264 into the rat nucleus accumbens using microspheres.
Journal of neurochemistry 1996;67(6):2417-24.
1996: J M Soleilhac; Chantal Lafuma; J M Porcher; G Auburtin; Bernard P Roques
Characterization of a soluble form of neutral endopeptidase-24.11 (EC 3.4.24.11) in human serum: enhancement of its activity in serum of underground miners exposed to coal dust particles.
European journal of clinical investigation 1996;26(11):1011-7.
1996: Bernard P Roques; Florence Noble
Association of enkephalin catabolism inhibitors and CCK-B antagonists: a potential use in the management of pain and opioid addiction.
Neurochemical research 1996;21(11):1397-410.
1996: H W D Matthes; Rafael Maldonado; Frédéric Simonin; O Valverde; Susan Slowe; I Kitchen; Katia Befort; Andrée Dierich; Marianne Le Meur; Pascal Dollé; Eleni T Tzavara; Jacques Hanoune; Bernard P Roques; B L Kieffer
Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene.
Nature 1996;383(6603):819-23.
1996: S Zini; Marie-Claude Fournie-Zaluski; E Chauvel; Bernard P Roques; Pierre Corvol; Catherine Llorens-Cortes
Identification of metabolic pathways of brain angiotensin II and III using specific aminopeptidase inhibitors: predominant role of angiotensin III in the control of vasopressin release.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(21):11968-73.
1996: J M Soleilhac; F Cornille; Loic MARTIN; Christine Lenoir; Marie-Claude Fournié-Zaluski; Bernard P Roques
A sensitive and rapid fluorescence-based assay for determination of tetanus toxin peptidase activity.
Analytical biochemistry 1996;241(1):120-7.
1996: O Valverde; Marie-Claude Fournié-Zaluski; Bernard P Roques; Rafael Maldonado
Similar involvement of several brain areas in the antinociception of endogenous and exogenous opioids.
European journal of pharmacology 1996;312(1):15-25.
1996: F Ruiz; Marie-Claude Fournié-Zaluski; Bernard P Roques; Rafael Maldonado
Similar decrease in spontaneous morphine abstinence by methadone and RB 101, an inhibitor of enkephalin catabolism.
British journal of pharmacology 1996;119(1):174-82.
1996: Valérie Daugé; A Mauborgne; F Cesselin; Marie-Claude Fournié-Zaluski; Bernard P Roques
The dual peptidase inhibitor RB101 induces a long-lasting increase in the extracellular level of Met-enkephalin-like material in the nucleus accumbens of freely moving rats.
Journal of neurochemistry 1996;67(3):1301-8.
1996: J H Weng; André Bado; Christiane Garbay; Bernard P Roques
Novel CCK-B receptor agonists: diketopiperazine analogues derived for CCK4 bioactive conformation.
Regulatory peptides 1996;65(1):3-9.
1996: Rafael Maldonado; J A Blendy; Eleni T Tzavara; Peter Gass; Bernard P Roques; Jacques Hanoune; Günther Schütz
Reduction of morphine abstinence in mice with a mutation in the gene encoding CREB.
Science (New York, N.Y.) 1996;273(5275):657-9.
1996: W Gonzalez; F Beslot; I Laboulandine; Marie-Claude Fournié-Zaluski; Bernard P Roques; Jean-Baptiste Michel
Inhibition of both angiotensin-converting enzyme and neutral endopeptidase by S21402 (RB105) in rats with experimental myocardial infarction.
The Journal of pharmacology and experimental therapeutics 1996;278(2):573-81.
1996: Xiaodong Li; Yudong Quan; E J Arts; Z Li; B D Preston; Hugues de Rocquigny; Bernard P Roques; Jean-Luc Darlix; Lawrence Kleiman; M A Parniak; Mark A Wainberg
Human immunodeficiency virus Type 1 nucleocapsid protein (NCp7) directs specific initiation of minus-strand DNA synthesis primed by human tRNA(Lys3) in vitro: studies of viral RNA molecules mutated in regions that flank the primer binding site.
Journal of virology 1996;70(8):4996-5004.
1996: P M Girard; Hugues de Rocquigny; Bernard P Roques; J Paoletti
A model of PSI dimerization: destabilization of the C278-G303 stem-loop by the nucleocapsid protein (NCp10) of MoMuLV.
Biochemistry 1996;35(26):8705-14.
1996: MC Fournie-Zaluski; Pascale Coric; V Thery; W Gonzalez; Hervé MEUDAL; Serge Turcaud; Jean-Baptiste Michel; Bernard P Roques
Design of orally active dual inhibitors of neutral endopeptidase and angiotensin-converting enzyme with long duration of action.
Journal of medicinal chemistry 1996;39(13):2594-608.
1996: Yves Mély; Hugues de Rocquigny; Nelly Morellet; Bernard P Roques; D Gérad
Zinc binding to the HIV-1 nucleocapsid protein: a thermodynamic investigation by fluorescence spectroscopy.
Biochemistry 1996;35(16):5175-82.
1996: J H Weng; A G Blommaert; Laurent Moizo; André Bado; B Ducos; A Böhme; Christiane Garbay; Bernard P Roques
Role of N- and C-terminal substituents on the CCK-B agonist-antagonist pharmacological profile of Boc-Trp-Phg-Asp-Nal-NH2 derivatives.
Bioorganic & medicinal chemistry 1996;4(4):563-73.
1996: N Goudreau; J H Weng; Bernard P Roques
Comparative conformational analysis of CCK-B agonist Boc-Trp-Phg-Asp-(1-Nal)-NH2 and CCK1-B antagonist Boc-Trp-Phg-Asp-(1-Nal)-N(Me)2 using 1HNMR spectroscopy and restrained molecular dynamics.
Archiv der Pharmazie 1996;329(4):197-204.
1996: Pascale Coric; Serge Turcaud; Hervé MEUDAL; Bernard P Roques; MC Fournie-Zaluski
Optimal recognition of neutral endopeptidase and angiotensin-converting enzyme active sites by mercaptoacyldipeptides as a means to design potent dual inhibitors.
Journal of medicinal chemistry 1996;39(6):1210-9.
1996: M E Million; P Mailliett; H Chen; G Bashiardes; J Boiziau; F Parker; A Commerçon; B Tocque; Bernard P Roques; Christiane Garbay
Synthesis and biological evaluation of a new series of phenylhydroquinone derivatives as inhibitors of EGF-R-associated PTK activity.
Anti-cancer drug design 1996;11(2):129-53.
1996: I Pham; W Gonzalez; J Doucet; MC Fournie-Zaluski; Bernard P Roques; Jean-Baptiste Michel
Effects of angiotensin-converting enzyme and neutral endopeptidase inhibitors: influence of bradykinin.
European journal of pharmacology 1996;296(3):267-76.
1996: A Jagerschmidt; N Guillaume-Rousselet; M L Vikland; N Goudreau; Bernard Maigret; Bernard P Roques
His381 of the rat CCKB receptor is essential for CCKB versus CCKA receptor antagonist selectivity.
European journal of pharmacology 1996;296(1):97-106.
1996: M Migaud; C Durieux; J Viereck; E Soroca-Lucas; Marie-Claude Fournié-Zaluski; Bernard P Roques
The in vivo metabolism of cholecystokinin (CCK-8) is essentially ensured by aminopeptidase A.
Peptides 1996;17(4):601-7.
1996: H Chen; G Bashiardes; Patrick Mailliet; A Commercon; F Sounigo; J Boiziau; F Parker; B Tocque; Bernard P Roques; Christiane Garbay
Synthesis and biological evaluation of a series of hydroxybenzylphenylamine derivatives as inhibitors of EGF receptor-associated tyrosine kinase activity.
Anti-cancer drug design 1996;11(1):49-71.
1995: Jacques Peyroux; F Beslot; N Claperon; M C Fournie-Zaluski; Bernard P Roques
Effect of endopeptidase-24.11 inhibitors and C-ANP receptor ligand on responses evoked in arterioles of rat cremaster muscle by atrial natriuretic peptide.
British journal of pharmacology 1995;116(8):3117-24.
1995: M E Million; J Boiziau; F Parker; B Tocque; Bernard P Roques; Christiane Garbay
Inhibition of the EGF-stimulated cellular proliferation of ER 22 cells by hydroxybiphenyl derivatives.
Journal of medicinal chemistry 1995;38(23):4693-703.
1995: O Valverde; A G Blommaert; Marie-Claude Fournié-Zaluski; Bernard P Roques; Rafael Maldonado
Weak tolerance to the antinociceptive effect induced by the association of a peptidase inhibitor and a CCKB receptor antagonist.
European journal of pharmacology 1995;286(1):79-93.
1995: Rafael Maldonado; O Valverde; Christiane Garbay; Bernard P Roques
Protein kinases in the locus coeruleus and periaqueductal gray matter are involved in the expression of opiate withdrawal.
Naunyn-Schmiedeberg's archives of pharmacology 1995;352(5):565-75.
1995: A Jagerschmidt; N Guillaume; N Goudreau; Bernard Maigret; Bernard P Roques
Mutation of Asp100 in the second transmembrane domain of the cholecystokinin B receptor increases antagonist binding and reduces signal transduction.
Molecular pharmacology 1995;48(5):783-9.
1995: V Tanchou; T Delaunay; M Bodéus; Bernard P Roques; Jean-Luc Darlix; Richard Benarous
Conformational changes between human immunodeficiency virus type 1 nucleocapsid protein NCp7 and its precursor NCp15 as detected by anti-NCp7 monoclonal antibodies.
The Journal of general virology 1995;76 ( Pt 10)():2457-66.
1995: Purificación Tejedor-Real; J A Mico; Rafael Maldonado; Bernard P Roques; Juan Gibert-Rahola
Implication of endogenous opioid system in the learned helplessness model of depression.
Pharmacology, biochemistry, and behavior 1995;52(1):145-52.
1995: C Smadja; Rafael Maldonado; Serge Turcaud; MC Fournie-Zaluski; Bernard P Roques
Opposite role of CCKA and CCKB receptors in the modulation of endogenous enkephalin antidepressant-like effects.
Psychopharmacology 1995;120(4):400-8.
1995: F Cornille; F Deloye; Marie-Claude Fournié-Zaluski; Bernard P Roques; Bernard Poulain
Inhibition of neurotransmitter release by synthetic proline-rich peptides shows that the N-terminal domain of vesicle-associated membrane protein/synaptobrevin is critical for neuro-exocytosis.
The Journal of biological chemistry 1995;270(28):16826-32.
1995: A Beaumont; Michael O'Donohue; N Paredes; N Rousselet; M Assicot; C Bohuon; Marie-Claude Fournié-Zaluski; Bernard P Roques
The role of histidine 231 in thermolysin-like enzymes. A site-directed mutagenesis study.
The Journal of biological chemistry 1995;270(28):16803-8.
1995: M Migaud; Bernard P Roques; C Durieux
Evidence for a high-affinity uptake system for cholecystokinin octapeptide (CCK8) in rat cortical synaptosomes.
The European journal of neuroscience 1995;7(5):1074-9.
1995: N Ladurelle; Bernard P Roques; Valérie Daugé
The transfer of rats from a familiar to a novel environment prolongs the increase of extracellular dopamine efflux induced by CCK8 in the posterior nucleus accumbens.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(4):3118-27.
1995: Rafael Maldonado; O Valverde; B Ducos; A G Blommaert; MC Fournie-Zaluski; Bernard P Roques
Inhibition of morphine withdrawal by the association of RB 101, an inhibitor of enkephalin catabolism, and the CCKB antagonist PD-134,308.
British journal of pharmacology 1995;114(5):1031-9.
1995: Florence Noble; Bernard P Roques
Assessment of endogenous enkephalins efficacy in the hot plate test in mice: comparative study with morphine.
Neuroscience letters 1995;185(2):75-8.
1995: V Dauge; P J Corringer; Bernard P Roques
CCKA, but not CCKB, agonists suppress the hyperlocomotion induced by endogenous enkephalins, protected from enzymatic degradation by systemic RB 101.
Pharmacology, biochemistry, and behavior 1995;50(2):133-9.
1995: Yves Mély; Hugues de Rocquigny; M Sorinas-Jimeno; G Keith; Bernard P Roques; R Marquet; Dominique Gérard
Binding of the HIV-1 nucleocapsid protein to the primer tRNA(3Lys), in vitro, is essentially not specific.
The Journal of biological chemistry 1995;270(4):1650-6.
1995: Florence Noble; A Blommaert; Marie-Claude Fournié-Zaluski; Bernard P Roques
A selective CCKB receptor antagonist potentiates, mu-, but not delta-opioid receptor-mediated antinociception in the formalin test.
European journal of pharmacology 1995;273(1-2):145-51.
1995: Bernard P Roques; Florence Noble
Dual inhibitors of enkephalin-degrading enzymes (neutral endopeptidase 24.11 and aminopeptidase N) as potential new medications in the management of pain and opioid addiction.
NIDA research monograph 1995;147():104-45.
1995: W Gonzalez Vera; Marie-Claude Fournié-Zaluski; I Pham; I Laboulandine; Bernard P Roques; Jean-Baptiste Michel
Hypotensive and natriuretic effects of RB 105, a new dual inhibitor of angiotensin converting enzyme and neutral endopeptidase in hypertensive rats.
The Journal of pharmacology and experimental therapeutics 1995;272(1):343-51.
1995: Bernard P Roques; Florence Noble; Philippe Crine; Marie-Claude Fournié-Zaluski
Inhibitors of neprilysin: design, pharmacological and clinical applications.
Methods in enzymology 1995;248():263-83.
1995: I Pham; Bernard I Lévy; Marie-Claude Fournié-Zaluski; P Poitevin; Bernard P Roques; Jean-Baptiste Michel
Acute hemodynamic effects of combined inhibition of neutral endopeptidase and angiotensin converting enzyme in spontaneously hypertensive rats.
Fundamental & clinical pharmacology 1995;9(2):153-60.
1994: M Derrien; Valérie Daugé; A Blommaert; Bernard P Roques
The selective CCK-B agonist, BC 264, impairs socially reinforced memory in the three-panel runway test in rats.
Behavioural brain research 1994;65(2):139-46.
1994: Florence Noble; C Smadja; Bernard P Roques
Role of endogenous cholecystokinin in the facilitation of mu-mediated antinociception by delta-opioid agonists.
The Journal of pharmacology and experimental therapeutics 1994;271(3):1127-34.
1994: N Goudreau; F Cornille; Marc Duchesne; F Parker; B Tocqué; Christiane Garbay; Bernard P Roques
NMR structure of the N-terminal SH3 domain of GRB2 and its complex with a proline-rich peptide from Sos.
Nature structural biology 1994;1(12):898-907.
1994: P E Milhiet; Marie-Cécile Giocondi; Philippe Crine; Christian Le Grimellec; Bernard P Roques; C Garbay-Jaureguiberry
Fate of a fluorescent inhibitor of endopeptidase-24.11 using enzyme-expressing MDCK cells. Modification of its cellular processing with a monoclonal antibody.
European journal of cell biology 1994;65(2):258-68.
1994: Yves Mély; N Jullian; Nelly Morellet; Hugues de Rocquigny; C Z Dong; Etienne Piémont; Bernard P Roques; Dominique Gérard
Spatial proximity of the HIV-1 nucleocapsid protein zinc fingers investigated by time-resolved fluorescence and fluorescence resonance energy transfer.
Biochemistry 1994;33(40):12085-91.
1994: A Jagerschmidt; T Popovici; M O'Donohue; Bernard P Roques
Identification and characterization of various cholecystokinin B receptor mRNA forms in rat brain tissue and partial determination of the cholecystokinin B receptor gene structure.
Journal of neurochemistry 1994;63(4):1199-206.
1994: E N Chauvel; Catherine Llorens-Cortès; Pascale Coric; Sherwin Wilk; Bernard P Roques; Marie-Claude Fournié-Zaluski
Differential inhibition of aminopeptidase A and aminopeptidase N by new beta-amino thiols.
Journal of medicinal chemistry 1994;37(18):2950-7.
1994: M Derrien; I McCort-Tranchepain; B Ducos; Bernard P Roques; C Durieux
Heterogeneity of CCK-B receptors involved in animal models of anxiety.
Pharmacology, biochemistry, and behavior 1994;49(1):133-41.
1994: N Ladurelle; C Durieux; Bernard P Roques; Valérie Daugé
Different modifications of the dopamine metabolism in the core and shell parts of the nucleus accumbens following CCK-A receptor stimulation in the shell region.
Neuroscience letters 1994;178(1):5-10.
1994: V Tanchou; T Delaunay; Hugues de Rocquigny; M Bodeus; Jean-Luc Darlix; Bernard P Roques; Richard Benarous
Monoclonal antibody-mediated inhibition of RNA binding and annealing activities of HIV type 1 nucleocapsid protein.
AIDS research and human retroviruses 1994;10(8):983-93.
1994: O Valverde; Rafael Maldonado; MC Fournie-Zaluski; Bernard P Roques
Cholecystokinin B antagonists strongly potentiate antinociception mediated by endogenous enkephalins.
The Journal of pharmacology and experimental therapeutics 1994;270(1):77-88.
1994: Rafael Maldonado; O Valverde; Serge Turcaud; Marie-Claude Fournié-Zaluski; Bernard P Roques
Antinociceptive response induced by mixed inhibitors of enkephalin catabolism in peripheral inflammation.
Pain 1994;58(1):77-83.
1994: I Gomez-Monterrey; A Beaumont; P Nemecek; Bernard P Roques; MC Fournie-Zaluski
New thiol inhibitors of neutral endopeptidase EC 3.4.24.11: synthesis and enzyme active-site recognition.
Journal of medicinal chemistry 1994;37(12):1865-73.
1994: Rafael Maldonado; O Valverde; M Derrien; Purificación Tejedor-Real; Bernard P Roques
Effects induced by BC 264, a selective agonist of CCK-B receptors, on morphine-dependent rats.
Pharmacology, biochemistry, and behavior 1994;48(2):363-9.
1994: Michael O'Donohue; Bernard P Roques; A Beaumont
Cloning and expression in Bacillus subtilis of the npr gene from Bacillus thermoproteolyticus Rokko coding for the thermostable metalloprotease thermolysin.
The Biochemical journal 1994;300 ( Pt 2)():599-603.
1994: M Migaud; Bernard P Roques; C Durieux
Effects of cholecystokinin octapeptide and BC 264, a potent and selective CCK-B agonist on aspartate and glutamate release from rat hippocampal slices.
Neuropharmacology 1994;33(6):737-43.
1994: F Cornille; N Goudreau; Damien Ficheux; H Niemann; Bernard P Roques
Solid-phase synthesis, conformational analysis and in vitro cleavage of synthetic human synaptobrevin II 1-93 by tetanus toxin L chain.
European journal of biochemistry / FEBS 1994;222(1):173-81.
1994: N Goudreau; C Guis; J M Soleilhac; Bernard P Roques
Dns-Gly-(p-NO2)Phe-beta Ala, a specific fluorogenic substrate for neutral endopeptidase 24.11.
Analytical biochemistry 1994;219(1):87-95.
1994: E N Chauvel; Pascale Coric; Catherine Llorens-Cortès; Sherwin Wilk; Bernard P Roques; Marie-Claude Fournié-Zaluski
Investigation of the active site of aminopeptidase A using a series of new thiol-containing inhibitors.
Journal of medicinal chemistry 1994;37(9):1339-46.
1994: Marie-Claude Fournié-Zaluski; W Gonzalez; Serge Turcaud; I Pham; Bernard P Roques; Jean-Baptiste Michel
Dual inhibition of angiotensin-converting enzyme and neutral endopeptidase by the orally active inhibitor mixanpril: a potential therapeutic approach in hypertension.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(9):4072-6.
1994: Marie-Claude Fournié-Zaluski; Pascale Coric; Serge Turcaud; N Rousselet; W Gonzalez; B Barbe; I Pham; N Jullian; Jean-Baptiste Michel; Bernard P Roques
New dual inhibitors of neutral endopeptidase and angiotensin-converting enzyme: rational design, bioavailability, and pharmacological responses in experimental hypertension.
Journal of medicinal chemistry 1994;37(8):1070-83.
1994: C Durieux; M Derrien; Rafael Maldonado; O Valverde; A Blommaert; Marie-Claude Fournié-Zaluski; Bernard P Roques
CCK-B antagonists exhibit antidepressant-like effects and potentiate endogenous enkephalin analgesia. Correlation with in vivo binding affinities and brain penetration.
Annals of the New York Academy of Sciences 1994;713():355-7.
1994: H Chen; J Boiziau; F Parker; Patrick Mailliet; A Commerçon; B Tocque; J B Le Pecq; Bernard P Roques; Christiane Garbay
Structure-activity relationships in a series of 5-[(2,5-dihydroxybenzyl)amino]salicylate inhibitors of EGF-receptor-associated tyrosine kinase: importance of additional hydrophobic aromatic interactions.
Journal of medicinal chemistry 1994;37(6):845-59.
1994: Y S Yang; Christiane Garbay; Marc Duchesne; F Cornille; N Jullian; N Fromage; B Tocque; Bernard P Roques
Solution structure of GAP SH3 domain by 1H NMR and spatial arrangement of essential Ras signaling-involved sequence.
The EMBO journal 1994;13(6):1270-9.
1994: Florence Noble; Pascale Coric; Serge Turcaud; Marie-Claude Fournié-Zaluski; Bernard P Roques
Assessment of physical dependence after continuous perfusion into the rat jugular vein of the mixed inhibitor of enkephalin-degrading enzymes, RB 101.
European journal of pharmacology 1994;253(3):283-7.
1994: M Derrien; C Durieux; Bernard P Roques
Antidepressant-like effects of CCKB antagonists in mice: antagonism by naltrindole.
British journal of pharmacology 1994;111(3):956-60.
1994: H Déméné; N Jullian; Nelly Morellet; Hugues de Rocquigny; F Cornille; Bernard Maigret; Bernard P Roques
Three-dimensional 1H NMR structure of the nucleocapsid protein NCp10 of Moloney murine leukemia virus.
Journal of biomolecular NMR 1994;4(2):153-70.
1994: N Goudreau; J H Weng; Bernard P Roques
Conformational analysis of CCK-B agonists using 1H-NMR and restrained molecular dynamics: comparison of biologically active Boc-Trp-(N-Me) Nle-Asp-Phe-NH2 and inactive Boc-Trp-(N-Me)Phe-Asp-Phe-NH2.
Biopolymers 1994;34(2):155-69.
1994: T N Akopyan; Y Couedel; M Orlowski; MC Fournie-Zaluski; Bernard P Roques
Proteolytic processing of farnesylated peptides: assay and partial purification from pig brain membranes of an endopeptidase which has the characteristics of E.C. 3.4.24.15.
Biochemical and biophysical research communications 1994;198(2):787-94.
1994: Nelly Morellet; Hugues de Rocquigny; Yves Mély; N Jullian; H Déméné; M Ottmann; Dominique Gérard; Jean-Luc Darlix; MC Fournie-Zaluski; Bernard P Roques
Conformational behaviour of the active and inactive forms of the nucleocapsid NCp7 of HIV-1 studied by 1H NMR.
Journal of molecular biology 1994;235(1):287-301.
1994: Florence Noble; Marie-Claude Fournié-Zaluski; Bernard P Roques
Paradoxical analgesia induced by low doses of naloxone is not potentiated by complete inhibition of enkephalin degradation.
Neuropharmacology 1994;33(1):135-40.
1993: H Chen; J Boiziau; F Parker; R Maroun; B Tocque; Bernard P Roques; C Garbay-Jaureguiberry
Synthesis and structure-activity studies of a series of [(hydroxybenzyl)amino]salicylates as inhibitors of EGF receptor-associated tyrosine kinase activity.
Journal of medicinal chemistry 1993;36(25):4094-8.
1993: N Ladurelle; G Keller; Bernard P Roques; Valérie Daugé
Effects of CCK8 and of the CCKB-selective agonist BC264 on extracellular dopamine content in the anterior and posterior nucleus accumbens: a microdialysis study in freely moving rats.
Brain research 1993;628(1-2):254-62.
1993: F Pasquini; Catherine Jomary; C Garbay-Jaureguiberry; Bernard P Roques; Alain Beaudet
[125I]azido-DTLET as a tool for selective covalent labeling of delta-opioid receptors in rat brain sections.
European journal of pharmacology 1993;243(1):39-45.
1993: A G Blommaert; J H Weng; A Dorville; I McCort; B Ducos; C Durieux; Bernard P Roques
Cholecystokinin peptidomimetics as selective CCK-B antagonists: design, synthesis, and in vitro and in vivo biochemical properties.
Journal of medicinal chemistry 1993;36(20):2868-77.
1993: Yves Mély; Etienne Piémont; M Sorinas-Jimeno; Hugues de Rocquigny; N Jullian; Nelly Morellet; Bernard P Roques; Dominique Gérard
Structural and dynamic characterization of the aromatic amino acids of the human immunodeficiency virus type I nucleocapsid protein zinc fingers and their involvement in heterologous tRNA(Phe) binding: a steady-state and time-resolved fluorescence study.
Biophysical journal 1993;65(4):1513-22.
1993: M Derrien; Florence Noble; Rafael Maldonado; Bernard P Roques
Cholecystokinin-A but not cholecystokinin-B receptor stimulation induces endogenous opioid-dependent antinociceptive effects in the hot plate test in mice.
Neuroscience letters 1993;160(2):193-6.
1993: N Julian; H Demene; Nelly Morellet; Bernard Maigret; Bernard P Roques
Replacement of His23 by Cys in a zinc finger of HIV-1 NCp7 led to a change in 1H NMR-derived 3D structure and to a loss of biological activity.
FEBS letters 1993;331(1-2):43-8.
1993: Florence Noble; M Derrien; Bernard P Roques
Modulation of opioid antinociception by CCK at the supraspinal level: evidence of regulatory mechanisms between CCK and enkephalin systems in the control of pain.
British journal of pharmacology 1993;109(4):1064-70.
1993: Bernard P Roques
Zinc metallopeptidases: active site structure and design of selective and mixed inhibitors: new approaches in the search for analgesics and anti-hypertensives.
Biochemical Society transactions 1993;21 ( Pt 3)(3):678-85.
1993: M Derrien; C Durieux; Valérie Daugé; Bernard P Roques
Involvement of D2 dopaminergic receptors in the emotional and motivational responses induced by injection of CCK-8 in the posterior part of the rat nucleus accumbens.
Brain research 1993;617(2):181-8.
1993: Purificación Tejedor-Real; Juan A Micó; Rafael Maldonado; Bernard P Roques; Juan Gibert-Rahola
Effect of mixed (RB 38A) and selective (RB 38B) inhibitors of enkephalin degrading enzymes on a model of depression in the rat.
Biological psychiatry 1993;34(1-2):100-7.
1993: Rafael Maldonado; M Derrien; Florence Noble; Bernard P Roques
Association of the peptidase inhibitor RB 101 and a CCK-B antagonist strongly enhances antinociceptive responses.
Neuroreport 1993;4(7):947-50.
1993: Rafael Maldonado; D Girdlestone; Bernard P Roques
RP 67580, a selective antagonist of neurokinin-1 receptors, modifies some of the naloxone-precipitated morphine withdrawal signs in rats.
Neuroscience letters 1993;156(1-2):135-40.
1993: C Guis; L Bruetschy; Hervé MEUDAL; Bernard P Roques; G A Gacel
Investigation of the structural parameters involved in the delta-opioid selectivity of several families of opioid peptides.
International journal of peptide and protein research 1993;41(6):576-86.
1993: I Pham; W Gonzalez; A I el Amrani; Marie-Claude Fournié-Zaluski; M Philippe; I Laboulandine; Bernard P Roques; Jean-Baptiste Michel
Effects of converting enzyme inhibitor and neutral endopeptidase inhibitor on blood pressure and renal function in experimental hypertension.
The Journal of pharmacology and experimental therapeutics 1993;265(3):1339-47.
1993: Hugues de Rocquigny; Damien Ficheux; Caroline Gabus; B Allain; MC Fournie-Zaluski; Jean-Luc Darlix; Bernard P Roques
Two short basic sequences surrounding the zinc finger of nucleocapsid protein NCp10 of Moloney murine leukemia virus are critical for RNA annealing activity.
Nucleic acids research 1993;21(4):823-9.
1993: Y Mely; Hugues de Rocquigny; Etienne Piémont; H Déméné; N Jullian; Marie-Claude Fournié-Zaluski; Bernard P Roques; Dominique Gérard
Influence of the N- and C-terminal chains on the zinc-binding and conformational properties of the central zinc-finger structure of Moloney murine leukaemia virus nucleocapsid protein: a steady-state and time-resolved fluorescence study.
Biochimica et biophysica acta 1993;1161(1):6-18.
1993: Florence Noble; Marie-Claude Fournié-Zaluski; Bernard P Roques
Unlike morphine the endogenous enkephalins protected by RB101 are unable to establish a conditioned place preference in mice.
European journal of pharmacology 1993;230(2):139-49.
1993: I Gomez-Monterrey; Serge Turcaud; E Lucas; L Bruetschy; Bernard P Roques; Marie-Claude Fournié-Zaluski
Exploration of neutral endopeptidase active site by a series of new thiol-containing inhibitors.
Journal of medicinal chemistry 1993;36(1):87-94.
1993: P J Corringer; J H Weng; B Ducos; C Durieux; P Boudeau; A Bohme; Bernard P Roques
CCK-B agonist or antagonist activities of structurally hindered and peptidase-resistant Boc-CCK4 derivatives.
Journal of medicinal chemistry 1993;36(1):166-72.
1992: Valérie Daugé; Peter W Kalivas; T Duffy; Bernard P Roques
Effect of inhibiting enkephalin catabolism in the VTA on motor activity and extracellular dopamine.
Brain research 1992;599(2):209-14.
1992: F Pasquini; P Bochet; C Garbay-Jaureguiberry; Bernard P Roques; Jean Rossier; Alain Beaudet
Electron microscopic localization of photoaffinity-labelled delta opioid receptors in the neostriatum of the rat.
The Journal of comparative neurology 1992;326(2):229-44.
1992: I Pham; A I el Amrani; Marie-Claude Fournié-Zaluski; P Corvol; Bernard P Roques; Jean-Baptiste Michel
Effects of the selective neutral endopeptidase inhibitor, retrothiorphan, on renal function and blood pressure in conscious normotensive Wistar and hypertensive DOCA-salt rats.
Journal of cardiovascular pharmacology 1992;20(6):847-57.
1992: Florence Noble; Pascale Coric; Marie-Claude Fournié-Zaluski; Bernard P Roques
Lack of physical dependence in mice after repeated systemic administration of the mixed inhibitor prodrug of enkephalin-degrading enzymes, RB101.
European journal of pharmacology 1992;223(1):91-6.
1992: Florence Noble; Serge Turcaud; Marie-Claude Fournié-Zaluski; Bernard P Roques
Repeated systemic administration of the mixed inhibitor of enkephalin-degrading enzymes, RB101, does not induce either antinociceptive tolerance or cross-tolerance with morphine.
European journal of pharmacology 1992;223(1):83-9.
1992: V Dauge; M Derrien; C Durieux; Florence Noble; P J Corringer; Bernard P Roques
[Study of induced effects by selective CCKB agonists cholecystokinin in the nociception and behavior in rodents].
Thérapie 1992;47(6):531-9.
1992: T N Akopyan; Y Couedel; A Beaumont; MC Fournie-Zaluski; Bernard P Roques
Cleavage of farnesylated COOH-terminal heptapeptide of mouse N-ras by brain microsomal membranes: evidence for a carboxypeptidase which specifically removes the COOH-terminal methionine.
Biochemical and biophysical research communications 1992;187(3):1336-42.
1992: P E Milhiet; F Dennin; Marie-Cécile Giocondi; Christian Le Grimellec; C Garbay-Jaureguiberry; C Boucheix; Bernard P Roques
Detection of neutral endopeptidase-24.11/CD10 by flow cytometry and photomicroscopy using a new fluorescent inhibitor.
Analytical biochemistry 1992;205(1):57-64.
1992: Nelly Morellet; N Jullian; Hugues de Rocquigny; Bernard Maigret; Jean-Luc Darlix; Bernard P Roques
Determination of the structure of the nucleocapsid protein NCp7 from the human immunodeficiency virus type 1 by 1H NMR.
The EMBO journal 1992;11(8):3059-65.
1992: Hugues de Rocquigny; Caroline Gabus; A Vincent; Marie-Claude Fournié-Zaluski; Bernard P Roques; Jean-Luc Darlix
Viral RNA annealing activities of human immunodeficiency virus type 1 nucleocapsid protein require only peptide domains outside the zinc fingers.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(14):6472-6.
1992: Marie-Claude Fournié-Zaluski; J M Soleilhac; Serge Turcaud; R Laï-Kuen; Philippe Crine; A Beaumont; Bernard P Roques
Development of [125I]RB104, a potent inhibitor of neutral endopeptidase 24.11, and its use in detecting nanogram quantities of the enzyme by "inhibitor gel electrophoresis".
Proceedings of the National Academy of Sciences of the United States of America 1992;89(14):6388-92.
1992: Marie-Claude Fournié-Zaluski; Pascale Coric; Serge Turcaud; E Lucas; Florence Noble; Rafael Maldonado; Bernard P Roques
"Mixed inhibitor-prodrug" as a new approach toward systemically active inhibitors of enkephalin-degrading enzymes.
Journal of medicinal chemistry 1992;35(13):2473-81.
1992: Ana Baamonde; Valérie Daugé; Mariano Ruiz-Gayo; I G Fulga; Serge Turcaud; Marie-Claude Fournié-Zaluski; Bernard P Roques
Antidepressant-type effects of endogenous enkephalins protected by systemic RB 101 are mediated by opioid delta and dopamine D1 receptor stimulation.
European journal of pharmacology 1992;216(2):157-66.
1992: C Durieux; Mariano Ruiz-Gayo; P J Corringer; F Bergeron; B Ducos; Bernard P Roques
[3H]pBC 264, a suitable probe for studying cholecystokinin-B receptors: binding characteristics in rodent brains and comparison with [3H]SNF 8702.
Molecular pharmacology 1992;41(6):1089-95.
1992: C Garbay-Jaureguiberry; Damien Ficheux; Bernard P Roques
Solid phase synthesis of peptides containing the non-hydrolysable analog of (O)phosphotyrosine, p(CH2PO3H2)Phe. Application to the synthesis of 344-357 sequences of the beta 2 adrenergic receptor.
International journal of peptide and protein research 1992;39(6):523-7.
1992: B Gopalakrishnan; Bernard P Roques
Do antigenic peptides have a unique sense of direction inside the MHC binding groove? A molecular modelling study.
FEBS letters 1992;303(2-3):224-8.
1992: P E Milhiet; A Beaumont; C Garbay-Jaureguiberry; Bernard P Roques
Increase of neutral endopeptidase-24.11 with cellular density and enzyme modulation with an inhibitor on human Reh6 cell line.
Biochemical pharmacology 1992;43(8):1711-5.
1992: Marie-Claude Fournié-Zaluski; Pascale Coric; Serge Turcaud; L Bruetschy; E Lucas; Florence Noble; Bernard P Roques
Potent and systemically active aminopeptidase N inhibitors designed from active-site investigation.
Journal of medicinal chemistry 1992;35(7):1259-66.
1992: R Maldonado; Marie-Claude Fournié-Zaluski; Bernard P Roques
Attenuation of the morphine withdrawal syndrome by inhibition of catabolism of endogenous enkephalins in the periaqueductal gray matter.
Naunyn-Schmiedeberg's archives of pharmacology 1992;345(4):466-72.
1992: Florence Noble; J M Soleilhac; E Soroca-Lucas; Serge Turcaud; MC Fournie-Zaluski; Bernard P Roques
Inhibition of the enkephalin-metabolizing enzymes by the first systemically active mixed inhibitor prodrug RB 101 induces potent analgesic responses in mice and rats.
The Journal of pharmacology and experimental therapeutics 1992;261(1):181-90.
1992: J M Soleilhac; E Lucas; A Beaumont; Serge Turcaud; Jean-Baptiste Michel; Damien Ficheux; Marie-Claude Fournié-Zaluski; Bernard P Roques
A 94-kDa protein, identified as neutral endopeptidase-24.11, can inactivate atrial natriuretic peptide in the vascular endothelium.
Molecular pharmacology 1992;41(4):609-14.
1992: Bernard P Roques
Peptidomimetics as receptors agonists or peptidase inhibitors: a structural approach in the field of enkephalins, ANP and CCK.
Biopolymers 1992;32(4):407-10.
1992: A Helene; P E Milhiet; H Haouas; C Boucheix; A Beaumont; Bernard P Roques
Effects of monoclonal antibodies raised against the common acute lymphoblastic leukemia antigen on endopeptidase-24.11 activity.
Biochemical pharmacology 1992;43(4):809-14.
1992: Mariano Ruiz-Gayo; Ana Baamonde; Serge Turcaud; MC Fournie-Zaluski; Bernard P Roques
In vivo occupation of mouse brain opioid receptors by endogenous enkephalins: blockade of enkephalin degrading enzymes by RB 101 inhibits [3H]diprenorphine binding.
Brain research 1992;571(2):306-12.
1992: C Garbay-Jaureguiberry; M C Barsi; Alain Jacquemin-Sablon; J B Le Pecq; Bernard P Roques
Synthesis and biological activity of new dimers in the 7H-pyrido[4,3-c] carbazole antitumor series.
Journal of medicinal chemistry 1992;35(1):72-81.
1992: Valérie Daugé; M Derrien; J C Blanchard; Bernard P Roques
The selective CCK-B agonist, BC 264 injected in the antero-lateral part of the nucleus accumbens, reduces the spontaneous alternation behaviour of rats.
Neuropharmacology 1992;31(1):67-75.
1992: I McCort-Tranchepain; Damien Ficheux; C Durieux; Bernard P Roques
Replacement of Tyr-SO3H by a p-carboxymethyl-phenylalanine in a CCK8-derivative preserves its high affinity for CCK-B receptor.
International journal of peptide and protein research 1992;39(1):48-57.
1992: Florence Noble; Bernard P Roques
[Selective opioid agonists and inhibitors of enkephalin degradation enzymes: pharmacological and clinical values].
Comptes rendus des séances de la Société de biologie et de ses filiales 1992;186(1-2):37-60.
1992: M P Morin-Surun; E Boudinot; M C Fournie-Zaluski; Jean Champagnat; Bernard P Roques; M Denavit-Saubie
Control of breathing by endogenous opioid peptides: possible involvement in sudden infant death syndrome.
Neurochemistry international 1992;20(1):103-7.
1991: C Durieux; Mariano Ruiz-Gayo; Bernard P Roques
In vivo binding affinities of cholecystokinin agonists and antagonists determined using the selective CCKB agonist [3H]pBC 264.
European journal of pharmacology 1991;209(3):185-93.
1991: G Calenco-Choukroun; Valérie Daugé; G Gacel; Bernard P Roques
Lesion of dopamine mesolimbic neurons blocks behavioral effects induced by the endogenous enkephalins but not by a mu-opioid receptor agonist.
European journal of pharmacology 1991;209(3):267-71.
1991: Hugues de Rocquigny; Damien Ficheux; Caroline Gabus; Marie-Claude Fournié-Zaluski; Jean-Luc Darlix; Bernard P Roques
First large scale chemical synthesis of the 72 amino acid HIV-1 nucleocapsid protein NCp7 in an active form.
Biochemical and biophysical research communications 1991;180(2):1010-8.
1991: Joel Pothier; Muriel DELEPIERRE; M C Barsi; C Garbay-Jaureguiberry; J Igolen; Marc Le Bret; Bernard P Roques
Comparison of the bis-intercalating complexes formed between either ditercalinium or a flexible analogue and d(CpGpCpG)2 or d(TpTpCpGpCpGpApA)2 minihelices: 1H- and 31P-NMR analyses.
Biopolymers 1991;31(11):1309-23.
1991: Jacqueline N Crawley; S M Fiske; C Durieux; M Derrien; Bernard P Roques
Centrally administered cholecystokinin suppresses feeding through a peripheral-type receptor mechanism.
The Journal of pharmacology and experimental therapeutics 1991;257(3):1076-80.
1991: Y Mely; F Cornille; Marie-Claude Fournié-Zaluski; Jean-Luc Darlix; Bernard P Roques; Dominique Gérard
Investigation of zinc-binding affinities of Moloney murine leukemia virus nucleocapsid protein and its related zinc finger and modified peptides.
Biopolymers 1991;31(7):899-906.
1991: F Barcelo; G Muzard; R Mendoza; B Révet; Bernard P Roques; J B Le Pecq
Removal of DNA curving by DNA ligands: gel electrophoresis study.
Biochemistry 1991;30(20):4863-73.
1991: D Pattou; Bernard Maigret; MC Fournie-Zaluski; Bernard P Roques
Computational analysis of conformational behavior of cholecystokinin fragments. I-CCK4, CCK5, CCK6 and CCK7 molecules.
International journal of peptide and protein research 1991;37(5):440-50.
1991: André Bado; C Durieux; Laurent Moizo; Bernard P Roques; MJ Lewin
Cholecystokinin-A receptor mediation of food intake in cats.
The American journal of physiology 1991;260(4 Pt 2):R693-7.
1991: R Gonzalez-Muniz; F Cornille; F Bergeron; Damien Ficheux; Joel Pothier; C Durieux; Bernard P Roques
Solid phase synthesis of a fully active analogue of cholecystokinin using the acid-stable Boc-Phe (p-CH2) SO3H as a substitute for Boc-Tyr(SO3H) in CCK8.
International journal of peptide and protein research 1991;37(4):331-40.
1991: A Helene; A Beaumont; Bernard P Roques
Functional residues at the active site of aminopeptidase N.
European journal of biochemistry / FEBS 1991;196(2):385-93.
1991: Zara de Saint-Hilaire; Bernard P Roques; S Nicolaïdis
Effect of a highly selective central CCK-B receptor agonist: BC-264 on rat sleep.
Pharmacology, biochemistry, and behavior 1991;38(3):545-8.
1991: C Schmidt; J Peyroux; F Noble; Marie-Claude Fournié-Zaluski; Bernard P Roques
Analgesic responses elicited by endogenous enkephalins (protected by mixed peptidase inhibitors) in a variety of morphine-sensitive noxious tests.
European journal of pharmacology 1991;192(2):253-62.
1991: R C Maroun; Bernard P Roques
Induction of DNA bending by bifunctional intercalating agents of the 7H-pyridocarbazole family.
Biophysical chemistry 1991;39(1):45-56.
1991: P Delay-Goyet; Mariano Ruiz-Gayo; Ana Baamonde; G Gacel; J L Morgat; Bernard P Roques
Brain passage of BUBU, a highly selective and potent agonist for delta opioid receptors: in vivo binding and mu versus delta receptors occupancy.
Pharmacology, biochemistry, and behavior 1991;38(1):155-62.
1991: G Calenco-Choukroun; Valérie Daugé; G Gacel; Jean Féger; Bernard P Roques
Opioid delta agonists and endogenous enkephalins induce different emotional reactivity than mu agonists after injection in the rat ventral tegmental area.
Psychopharmacology 1991;103(4):493-502.
1990: F Cornille; Y Mely; Damien Ficheux; I Savignol; D Gerard; Jean-Luc Darlix; MC Fournie-Zaluski; Bernard P Roques
Solid phase synthesis of the retroviral nucleocapsid protein NCp10 of Moloney murine leukaemia virus and related "zinc-fingers" in free SH forms. Influence of zinc chelation on structural and biochemical properties.
International journal of peptide and protein research 1990;36(6):551-8.
1990: R Gonzalez-Muniz; F Bergeron; I Marseigne; C Durieux; Bernard P Roques
Boc-Trp-Orn(Z)-Asp-NH2 and derivatives: a new family of CCK antagonists.
Journal of medicinal chemistry 1990;33(12):3199-204.
1990: Bernard P Roques; G Gacel; Valérie Daugé; Ana Baamonde; G Calenco; Serge Turcaud; Pascale Coric; Marie-Claude Fournié-Zaluski
Novel approaches in the development of new analgesics.
Neurophysiologie clinique = Clinical neurophysiology 1990;20(5):369-87.
1990: G A Gacel; E Fellion; A Baamonde; V Dauge; Bernard P Roques
Synthesis, biochemical and pharmacological properties of BUBUC, a highly selective and systemically active agonist for in vivo studies of delta-opioid receptors.
Peptides 1990;11(5):983-8.
1990: Bernard P Roques; A Beaumont
Neutral endopeptidase-24.11 inhibitors: from analgesics to antihypertensives?
Trends in pharmacological sciences 1990;11(6):245-9.
1990: J M Zajac; A Bigeard; P Delay-Goyet; Bernard P Roques
Affinity states of rat brain opioid receptors in different tissue preparations.
Journal of neurochemistry 1990;54(3):992-9.
1990: B Lambert; E Segal-Bendirdjian; C Esnault; J B Le Pecq; Bernard P Roques; B Jones; anthony yeung
Recognition by the DNA repair system of DNA structural alterations induced by reversible drug-DNA interactions.
Anti-cancer drug design 1990;5(1):43-53.
1990: P Delay-Goyet; J M Zajac; Bernard P Roques
Improved quantitative radioautography of rat brain ?-opioid binding sites using [(3)H]DSTBULET, a new highly potent and selective linear enkephalin analogue.
Neurochemistry international 1990;16(3):341-68.
1990: V Dauge; Georg Andrees Bohme; Jacqueline N Crawley; C Durieux; J M Stutzmann; J Feger; J C Blanchard; Bernard P Roques
Investigation of behavioral and electrophysiological responses induced by selective stimulation of CCKB receptors by using a new highly potent CCK analog, BC 264.
Synapse (New York, N.Y.) 1990;6(1):73-80.
1990: C Esnault; Stephen Brown; E Segal-Bendirdjian; Dominique Coulaud; Zohar Mishal; Bernard P Roques; J B Le Pecq
Selective alteration of mitochondrial function by Ditercalinium (NSC 335153), a DNA bisintercalating agent.
Biochemical pharmacology 1990;39(1):109-22.
1990: G Calenco-Choukroun; Valérie Daugé; Jean Féger; Bernard P Roques
Behavioral effects of endogenous or exogenous (mu, delta) opioid peptides: relation with DA mesolimbic pathways.
Progress in clinical and biological research 1990;328():417-20.
1989: R Maroun; Muriel DELEPIERRE; Bernard P Roques
Intercalative binding of ditercalinium to d(CpGpCpG)2: a theoretical study.
Journal of biomolecular structure & dynamics 1989;7(3):607-21.
1989: Muriel DELEPIERRE; Carine van Heijenoort; J Igolen; Joel Pothier; Marc Le Bret; Bernard P Roques
Reassessment of structural characteristics of the d(CGCG)2:actinomycin D complex from complete 1H and 31P NMR.
Journal of biomolecular structure & dynamics 1989;7(3):557-89.
1989: P Delay-Goyet; V Kayser; J M Zajac; G Guilbaud; J M Besson; Bernard P Roques
Lack of significant changes in mu, delta opioid binding sites and neutral endopeptidase EC 3.4.24.11 in the brain and spinal cord of arthritic rats.
Neuropharmacology 1989;28(12):1341-8.
1989: E Meucci; P Delay-Goyet; Bernard P Roques; J M Zajac
Binding in vivo of selective mu and delta opioid receptor agonists: opioid receptor occupancy by endogenous enkephalins.
European journal of pharmacology 1989;171(2-3):167-78.
1989: Muriel DELEPIERRE; R Maroun; C Garbay-Jaureguiberry; J Igolen; Bernard P Roques
1H and 31P nuclear magnetic resonance studies of the differences in DNA deformation induced by anti-tumoral 7H-pyrido[4,3-c]carbazole dimers.
Journal of molecular biology 1989;210(1):211-28.
1989: P Lanaud; T Popovici; E Normand; C Lemoine; Bertrand Bloch; Bernard P Roques
Distribution of CCK mRNA in particular regions (hippocampus, periaqueductal grey and thalamus) of the rat by in situ hybridization.
Neuroscience letters 1989;104(1-2):38-42.
1989: C Durieux; P J Corringer; F Bergeron; Bernard P Roques
[3H]pBC 264, first highly potent and very selective radioligand for CCK-B receptors.
European journal of pharmacology 1989;168(2):269-70.
1989: J Belleney; G Gacel; Marie-Claude Fournié-Zaluski; Bernard Maigret; Bernard P Roques
Delta opioid receptor selectivity induced by conformational constraints in linear enkephalin-related peptides: 1H 400-MHz NMR study and theoretical calculations.
Biochemistry 1989;28(18):7392-400.
1989: B Lambert; Beverly Jones; Bernard P Roques; J B Le Pecq; anthony yeung
The noncovalent complex between DNA and the bifunctional intercalator ditercalinium is a substrate for the UvrABC endonuclease of Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(17):6557-61.
1989: Valérie Daugé; P Steimes; M Derrien; N Beau; Bernard P Roques; Jean Féger
CCK8 effects on motivational and emotional states of rats involve CCKA receptors of the postero-median part of the nucleus accumbens.
Pharmacology, biochemistry, and behavior 1989;34(1):157-63.
1989: J Xie; J M Soleilhac; N Renwart; J Peyroux; Bernard P Roques; Marie-Claude Fournié-Zaluski
Inhibitors of the enkephalin degrading enzymes. Modulation of activity of hydroxamate containing compounds by modifications of the C-terminal residue.
International journal of peptide and protein research 1989;34(3):246-55.
1989: P Delay-Goyet; J M Zajac; Bernard P Roques
Effects of repeated treatment with haloperidol on rat striatal neutral endopeptidase, and on mu- and delta-opioid binding sites: comparison with chronic morphine and chronic kelatorphan.
Neuroscience letters 1989;103(2):197-202.
1989: N Jamin; P Roy; F Fridlansky; Muriel DELEPIERRE; E Milgrom; Bernard P Roques; Jean-Paul Mornon
Preliminary assignments of the aromatic and some methyl group resonances of the 1H-NMR spectrum of the oxidized form of uteroglobin. Application to the interaction of oxidized uteroglobin with progesterone.
European journal of biochemistry / FEBS 1989;183(1):219-26.
1989: J Xie; J M Soleilhac; C Schmidt; J Peyroux; Bernard P Roques; Marie-Claude Fournié-Zaluski
New kelatorphan-related inhibitors of enkephalin metabolism: improved antinociceptive properties.
Journal of medicinal chemistry 1989;32(7):1497-503.
1989: B Charpentier; A Dor; P Roy; P England; H Pham; C Durieux; Bernard P Roques
Synthesis and binding affinities of cyclic and related linear analogues of CCK8 selective for central receptors.
Journal of medicinal chemistry 1989;32(6):1184-90.
1989: A Beaumont; J C Brouet; Bernard P Roques
Neutral endopeptidase 24.11 and angiotensin converting enzyme like activity in CALLA positive and CALLA negative lymphoid cells.
Biochemical and biophysical research communications 1989;160(3):1323-9.
1989: Valérie Daugé; A Dor; Jean Féger; Bernard P Roques
The behavioral effects of CCK8 injected into the medial nucleus accumbens are dependent on the motivational state of the rat.
European journal of pharmacology 1989;163(1):25-32.
1989: P Rigaudy; J Y Charcosset; C Garbay-Jaureguiberry; Alain Jacquemin-Sablon; Bernard P Roques
Attempts to target antitumor drugs toward opioid receptor-rich mouse tumor cells with enkephalin-ellipticinium conjugates.
Cancer research 1989;49(7):1836-42.
1989: Judith Markovits; C Garbay-Jaureguiberry; Bernard P Roques; J B Le Pecq
Acridine dimers: influence of the intercalating ring and of the linking-chain nature on the equilibrium and kinetic DNA-binding parameters.
European journal of biochemistry / FEBS 1989;180(2):359-66.
1989: Marie-Claude Fournié-Zaluski; J F Hernandez; J M Soleilhac; N Renwart; J Peyroux; J Xie; Bernard P Roques
Enkephalin-degrading enzyme inhibitors. Crucial role of the C-terminal residue on the inhibitory potencies of retro-hydroxamate dipeptides.
International journal of peptide and protein research 1989;33(2):146-53.
1989: I Marseigne; P Roy; A Dor; C Durieux; Didier Pélaprat; Michel Reibaud; J C Blanchard; Bernard P Roques
Full agonists of CCK8 containing a nonhydrolyzable sulfated tyrosine residue.
Journal of medicinal chemistry 1989;32(2):445-9.
1989: P Roy; B Charpentier; C Durieux; A Dor; Bernard P Roques
Conformational behavior of cyclic CCK-related peptides determined by 400-MHz 1H-NMR: relationships with affinity and selectivity for brain receptors.
Biopolymers 1989;28(1):69-79.
1989: D Pelaprat; V Dauge; C Durieux; B Charpentier; Bernard P Roques
[Co-localization of CCK and dopamine. Biochemical and pharmacological aspects].
L'Encéphale 1989;15 Spec No():85-9.
1989: V Daugé; P Rossignol; Bernard P Roques
Blockade of dopamine receptors reverses the behavioral effects of endogenous enkephalins in the Nucleus caudatus but not in the Nucleus accumbens: differential involvement of delta and mu opioid receptors.
Psychopharmacology 1989;99(2):168-75.
1988: P Laugaa; Muriel DELEPIERRE; B Dupraz; J Igolen; Bernard P Roques
NMR studies of tris-intercalation: solution structure and interaction of d(CTTCGCGCGAAG) with an acridine trimer.
Journal of biomolecular structure & dynamics 1988;6(3):421-41.
1988: R Fellous; Dominique Coulaud; I el Abed; Bernard P Roques; J B Le Pecq; Etienne Delain; Alain Gouyette
Cytoplasmic accumulation of ditercalinium in rat hepatocytes and induction of mitochondrial damage.
Cancer research 1988;48(22):6542-9.
1988: C Durieux; Didier Pélaprat; B Charpentier; J L Morgat; Bernard P Roques
Characterization of [3H] CCK4 binding sites in mouse and rat brain.
Neuropeptides 1988;12(3):141-8.
1988: P Bochet; C Icard-Liepkalns; F Pasquini; C Garbay-Jaureguiberry; Alain Beaudet; Bernard P Roques; Jean Rossier
Photoaffinity labeling of opioid delta receptors with an iodinated azido-ligand: [125I][D-Thr2,pN3Phe4,Leu5]enkephalyl-Thr6.
Molecular pharmacology 1988;34(4):436-43.
1988: G Gacel; Valérie Daugé; P Breuzé; P Delay-Goyet; Bernard P Roques
Development of conformationally constrained linear peptides exhibiting a high affinity and pronounced selectivity for delta opioid receptors.
Journal of medicinal chemistry 1988;31(10):1891-7.
1988: J F Hernandez; J M Soleilhac; Bernard P Roques; Marie-Claude Fournié-Zaluski
Retro-inverso concept applied to the complete inhibitors of enkephalin-degrading enzymes.
Journal of medicinal chemistry 1988;31(9):1825-31.
1988: E Segal-Bendirdjian; Dominique Coulaud; Bernard P Roques; J B Le Pecq
Selective loss of mitochondrial DNA after treatment of cells with ditercalinium (NSC 335153), an antitumor bis-intercalating agent.
Cancer research 1988;48(17):4982-92.
1988: B Charpentier; C Durieux; D Pelaprat; A Dor; Michel Reibaud; J C Blanchard; Bernard P Roques
Enzyme-resistant CCK analogs with high affinities for central receptors.
Peptides 1988;9(4):835-41.
1988: Muriel DELEPIERRE; J Igolen; Bernard P Roques
Study of the bisintercalation of the antitumor drug ditercalinium by 31P-NMR.
Biopolymers 1988;27(6):957-68.
1988: P Léon; C Garbay-Jaureguiberry; J B Le Pecq; Bernard P Roques
Relationship between the size and position of substituents on 7H-pyrido[4,3-c]carbazole monomers and dimers and their DNA binding and anti-tumor properties.
Anti-cancer drug design 1988;3(1):1-13.
1988: P Léon; C Garbay-Jaureguiberry; B Lambert; J B Le Pecq; Bernard P Roques
Asymmetrical bisintercalators as potential antitumor agents.
Journal of medicinal chemistry 1988;31(5):1021-6.
1988: I Marseigne; A Dor; D Bégué; Michel Reibaud; J L Zundel; J C Blanchard; Didier Pélaprat; Bernard P Roques
Synthesis and biological activity of CCK26-33-related analogues modified in position 31.
Journal of medicinal chemistry 1988;31(5):966-70.
1988: R H Shafer; Bernard P Roques; J B LePecq; Muriel DELEPIERRE
Chromomycin A3 binds to left-handed poly(dG-m5dC).
European journal of biochemistry / FEBS 1988;173(2):377-82.
1988: P Delay-Goyet; C Seguin; G Gacel; Bernard P Roques
[3H][D-Ser2(O-tert-butyl),Leu5]enkephalyl-Thr6 and [D-Ser2(O-tert-butyl),Leu5]enkephalyl-Thr6(O-tert-butyl). Two new enkephalin analogs with both a good selectivity and a high affinity toward delta-opioid binding sites.
The Journal of biological chemistry 1988;263(9):4124-30.
1988: B Charpentier; D Pelaprat; C Durieux; A Dor; Michel Reibaud; J C Blanchard; Bernard P Roques
Cyclic cholecystokinin analogues with high selectivity for central receptors.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(6):1968-72.
1988: Muriel DELEPIERRE; Bernard P Roques; B Langlois D'Estaintot; J Igolen
A general procedure for assigning the 31P spectra of drug-oligonucleotide complexes.
Journal of biomolecular structure & dynamics 1988;5(4):933-7.
1988: G Gacel; J M Zajac; P Delay-Goyet; Valérie Daugé; Bernard P Roques
Investigation of the structural parameters involved in the mu and delta opioid receptor discrimination of linear enkephalin-related peptides.
Journal of medicinal chemistry 1988;31(2):374-83.
1988: T Benchetrit; V Bissery; Jean-Paul Mornon; A Devault; P Crine; Bernard P Roques
Primary structure homologies between two zinc metallopeptidases, the neutral endopeptidase 24.11 ("enkephalinase") and thermolysin, through clustering analysis.
Biochemistry 1988;27(2):592-6.
1988: V Daugé; P Rossignol; Bernard P Roques
Comparison of the behavioural effects induced by administration in rat nucleus accumbens or nucleus caudatus of selective mu and delta opioid peptides or kelatorphan an inhibitor of enkephalin-degrading-enzymes.
Psychopharmacology 1988;96(3):343-52.
1987: G Waksman; E Hamel; P Delay-Goyet; Bernard P Roques
Neutral endopeptidase-24.11, mu and delta opioid receptors after selective brain lesions: an autoradiographic study.
Brain research 1987;436(2):205-16.
1987: P Léon; C Garbay-Jaureguiberry; M C Barsi; J B Le Pecq; Bernard P Roques
Modulation of the antitumor activity by methyl substitutions in the series of 7H-pyridocarbazole monomers and dimers.
Journal of medicinal chemistry 1987;30(11):2074-80.
1987: A Beaumont; J F Hernandez; P Chaillet; P Crine; Bernard P Roques
Irreversible photolabeling of active site of neutral endopeptidase-24.11 "enkephalinase" by azidothiorphan and [14C]-azidothiorphan.
Molecular pharmacology 1987;32(5):594-9.
1987: V Dauge; F Petit; P Rossignol; Bernard P Roques
Use of mu and delta opioid peptides of various selectivity gives further evidence of specific involvement of mu opioid receptors in supraspinal analgesia (tail-flick test).
European journal of pharmacology 1987;141(2):171-8.
1987: J Belleney; Bernard P Roques; MC Fournie-Zaluski
Comparison of conformational properties of linear and cyclic delta selective opioid ligands DTLET (Tyr-D X Thr-Gly-Phe-Leu-Thr) and DPLPE (Tyr-c[D X Pen-Gly-Phe-Pen]) by 1H n.m.r. spectroscopy.
International journal of peptide and protein research 1987;30(3):356-64.
1987: P Rigaudy; C Garbay-Jaureguiberry; Alain Jacquemin-Sablon; J B Le Pecq; Bernard P Roques
Synthesis and binding properties to DNA and to opioid receptors of enkephalin-ellipticinium conjugates.
International journal of peptide and protein research 1987;30(3):347-55.
1987: P Delay-Goyet; Bernard P Roques; J M Zajac
Differences of binding characteristics of non-selective opiates towards mu and delta receptor types.
Life sciences 1987;41(6):723-31.
1987: Muriel DELEPIERRE; A Delbarre; B Langlois d'Estaintot; J Igolen; Bernard P Roques
1H-NMR studies of a monointercalating drug into a d[CpGpCpG]2 minihelix.
Biopolymers 1987;26(7):981-1000.
1987: A Delbarre; Muriel DELEPIERRE; B Langlois d'Estaintot; J Igolen; Bernard P Roques
Bisintercalation of ditercalinium into a d[CpGpCpG]2 minihelix: structure and dynamics aspects--a 400-MHz 1H-NMR study.
Biopolymers 1987;26(7):1001-33.
1987: P Roy; Muriel DELEPIERRE; J Wagnon; Dino Nisato; Bernard P Roques
Conformational analysis of pepstatin and related renin inhibitors by 400 MHz 1H n.m.r. spectroscopy.
International journal of peptide and protein research 1987;30(1):44-53.
1987: P Delay-Goyet; J M Zajac; France Javoy-Agid; Yves Agid; Bernard P Roques
Regional distribution of mu, delta and kappa opioid receptors in human brains from controls and parkinsonian subjects.
Brain research 1987;414(1):8-14.
1987: A Delbarre; Muriel DELEPIERRE; Christiane Garbay; J Igolen; J B Le Pecq; Bernard P Roques
Geometry of the antitumor drug ditercalinium bisintercalated into d(CpGpCpG)2 by 1H NMR.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(8):2155-9.
1987: C Garbay-Jaureguiberry; P Laugâa; Muriel DELEPIERRE; S Laalami; G Muzard; J B Le Pecq; Bernard P Roques
DNA bis-intercalators as new anti-tumour agents: modulation of the anti-tumour activity by the linking chain rigidity in the ditercalinium series.
Anti-cancer drug design 1987;1(4):323-35.
1987: Didier Pélaprat; Y Broer; Jeanne-Marie Studler; Marc Peschanski; Jean-Pol Tassin; J Glowinski; W Rostène; Bernard P Roques
Autoradiography of CCK receptors in the rat brain using [(3)H]Boc[Nle(28)(31)]CCK(27)-(33) and [(125)I]bolton-hunter CCK(8). Functional significance of subregional distributions.
Neurochemistry international 1987;10(4):495-508.
1987: C Garbay-Jaureguiberry; C Esnault; Muriel DELEPIERRE; P Laugaa; S Laalami; J B Le Pecq; Bernard P Roques
Rational design of bis-intercalating drugs as antitumour agents: importance of rigidity in the linking chain.
Drugs under experimental and clinical research 1987;13(6):353-7.
1986: Muriel DELEPIERRE; B Langlois D'Estaintot; J Igolen; Bernard P Roques
Conformational studies of d(m5CpGpm5CpG) and d(CpGpCpG) by 1H and 31P NMR.
European journal of biochemistry / FEBS 1986;161(3):571-7.
1986: G Waksman; E Hamel; P Delay-Goyet; Bernard P Roques
Neuronal localization of the neutral endopeptidase 'enkephalinase' in rat brain revealed by lesions and autoradiography.
The EMBO journal 1986;5(12):3163-6.
1986: J M Benoist; Valérie Kayser; G Gacel; J M Zajac; M Gautron; Bernard P Roques; G Guilbaud
Differential depressive action of two mu and delta opioid ligands on neuronal responses to noxious stimuli in the thalamic ventrobasal complex of rat.
Brain research 1986;398(1):49-56.
1986: Judith Markovits; Y Pommier; M R Mattern; C Esnault; Bernard P Roques; J B Le Pecq; K W Kohn
Effects of the bifunctional antitumor intercalator ditercalinium on DNA in mouse leukemia L1210 cells and DNA topoisomerase II.
Cancer research 1986;46(11):5821-6.
1986: B Lambert; P Laugâa; Bernard P Roques; J B le Pecq
Cytotoxicity and SOS-inducing ability of ethidium and photoactivable analogs on E. coli ethidium-bromide-sensitive (Ebs) strains.
Mutation research 1986;166(3):243-54.
1986: E Lescot; G Muzard; Judith Markovits; J Belleney; Bernard P Roques; J B Le Pecq
Synthesis of 11H-pyridocarbazoles and derivatives. Comparison of their DNA binding and antitumor activity with those of 6H- and 7H-pyridocarbazoles.
Journal of medicinal chemistry 1986;29(9):1731-7.
1986: Marie-Claude Fournié-Zaluski; J Belleney; B Lux; C Durieux; Dominique Gérard; G Gacel; Bernard Maigret; Bernard P Roques
Conformational analysis of cholecystokinin CCK26-33 and related fragments by 1H NMR spectroscopy, fluorescence-transfer measurements, and calculations.
Biochemistry 1986;25(13):3778-87.
1986: Bernard Maigret; MC Fournie-Zaluski; Bernard P Roques; S Premilat
Proposals for the mu-active conformation of the enkephalin analog Tyr-cyclol(-N gamma-D-A2-bu-Gly-Phe-Leu-).
Molecular pharmacology 1986;29(3):314-20.
1986: C Durieux; B Charpentier; D Pelaprat; Bernard P Roques
Investigation on the metabolism of CCK8 analogues by rat brain slices.
Neuropeptides 1986;7(1):1-9.
1986: P Delay-Goyet; C Seguin; Valérie Daugé; G Calenco; J L Morgat; G Gacel; Bernard P Roques
[3H]DSTBULET, a new linear hexapeptide with both an improved selectivity and a high affinity for delta-opioid receptors.
NIDA research monograph 1986;75():197-200.
1985: Didier Pélaprat; J M Zajac; G Gacel; C Durieux; J L Morgat; A Sasaki; Bernard P Roques
[3H] Boc [Nle28, 31]CCK27-33, a new highly labelled ligand for CCK receptors: binding on brain and on pancreas.
Life sciences 1985;37(26):2483-90.
1985: P Laugâa; Judith Markovits; A Delbarre; J B Le Pecq; Bernard P Roques
DNA tris-intercalation: first acridine trimer with DNA affinity in the range of DNA regulatory proteins. Kinetic studies.
Biochemistry 1985;24(20):5567-75.
1985: MC Fournie-Zaluski; C Durieux; B Lux; J Belleney; P Pham; D Gerard; Bernard P Roques
Conformational analysis of cholecystokinin fragments CCK4, CCK5, and CCK6 by 1H-NMR spectroscopy and fluorescence-transfer measurements.
Biopolymers 1985;24(9):1663-81.
1985: A Delbarre; Muriel DELEPIERRE; J Igolen; J B Le Pecq; Bernard P Roques
1H NMR study of the structure of a pyridocarbazole dimer-d[CpGpCpG] complex.
Biochimie 1985;67(7-8):823-8.
1985: A Delbarre; R Oberlin; Bernard P Roques; J L Borgna; H Rochefort; J B Le Pecq; A Jacquemin-Sablon
Ellipticine derivatives with an affinity to the estrogen receptor, an approach to develop intercalating drugs with a specific effect on the hormone-dependent breast cancer.
Journal of medicinal chemistry 1985;28(6):752-61.
1985: C Durieux; B Charpentier; E Fellion; G Gacel; D Pelaprat; Bernard P Roques
Multiple cleavage sites of cholecystokinin heptapeptide by "enkephalinase".
Peptides 1985;6(3):495-501.
1985: P Delay-Goyet; J M Zajac; P Rigaudy; B Foucaud; Bernard P Roques
Comparative binding properties of linear and cyclic delta-selective enkephalin analogues: [3H]-[D-Thr2, Leu5] enkephalyl-Thr6 and [3H]-[D-Pen2, D-Pen5] enkephalin.
FEBS letters 1985;183(2):439-43.
1985: Bernard P Roques; C Durieux; G Gacel; Didier Pélaprat; Mariano Ruiz-Gayo; J Belleney; E Fellion; J M Zajac; Marie-Claude Fournié-Zaluski; Valérie Daugé
Studies on the conformation, enzymatic degradation, pharmacological potency, and binding properties in brain tissue of cholecystokinin-8 and new related peptides.
Annals of the New York Academy of Sciences 1985;448():61-75.
1984: C Garbay-Jaureguiberry; A Robichon; V Daugé; P Rossignol; Bernard P Roques
Highly selective photoaffinity labeling of mu and delta opioid receptors.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(24):7718-22.
1984: C Esnault; Bernard P Roques; A Jacquemin-Sablon; J B Le Pecq
Effects of new antitumor bifunctional intercalators derived from 7H-pyridocarbazole on sensitive and resistant L 1210 cells.
Cancer research 1984;44(10):4355-60.
1984: B Gaugain; Judith Markovits; J B Le Pecq; Bernard P Roques
DNA polyintercalation: comparison of DNA binding properties of an acridine dimer and trimer.
FEBS letters 1984;169(2):123-6.
1984: M P Morin-Surun; E Boudinot; G Gacel; Jean Champagnat; Bernard P Roques; M Denavit-Saubie
Different effects of mu and delta opiate agonists on respiration.
European journal of pharmacology 1984;98(2):235-40.
1983: C Durieux; J Belleney; J Y Lallemand; Bernard P Roques; MC Fournie-Zaluski
1H NMR conformational study of sulfated and non-sulfated cholecystokinin fragment CCK27-33: influence of the sulfate group on the peptide folding.
Biochemical and biophysical research communications 1983;114(2):705-12.
1983: P Laugaa; A Delbarre; J B Le Pecq; Bernard P Roques
Comparative binding of ethidium and three azido analogs to dinucleotides: affinity and intercalation geometry. A 1H NMR and visible spectroscopy study.
European journal of biochemistry / FEBS 1983;134(1):163-73.
1983: A Delbarre; M I Gourevitch; B Gaugain; J B Le Pecq; Bernard P Roques
1H NMR study of an ethidium dimer poly(dA-dT) complex: evidence of a transition between bis and monointercalation.
Nucleic acids research 1983;11(13):4467-82.
1983: J M Zajac; G Gacel; F Petit; P Dodey; P Rossignol; Bernard P Roques
Deltakephalin, Tyr-D-Thr-Gly-Phe-Leu-Thr: a new highly potent and fully specific agonist for opiate delta-receptors.
Biochemical and biophysical research communications 1983;111(2):390-7.
1983: Marie-Claude Fournié-Zaluski; P Chaillet; E Soroca-Lucas; H Marçais-Collado; J Costentin; Bernard P Roques
New carboxyalkyl inhibitors of brain enkephalinase: synthesis, biological activity, and analgesic properties.
Journal of medicinal chemistry 1983;26(1):60-5.
1982: Marie-Claude Fournié-Zaluski; E Soroca-Lucas; G Waksman; C Llorens; J C Schwartz; Bernard P Roques
Differential recognition of "enkephalinase" and angiotensin-converting enzyme by new carboxyalkyl inhibitors.
Life sciences 1982;31(26):2947-54.
1982: C Llorens; B Malfroy; J C Schwartz; G Gacel; Bernard P Roques; J Roy; J L Morgat; France Javoy-Agid; Yves Agid
Enkephalin dipeptidyl carboxypeptidase (enkephalinase) activity: selective radioassay, properties, and regional distribution in human brain.
Journal of neurochemistry 1982;39(4):1081-9.
1982: M David; C Moisand; J C Meunier; J L Morgat; G Gacel; Bernard P Roques
[3H]Tyr-D-Ser-Gly-Phe-Leu-Thr: a specific probe for the delta-opiate receptor subtype in brain membranes.
European journal of pharmacology 1982;78(3):385-7.
1982: J C Schwartz; S de la Baume; C Llorens; B Malfroy; E Soroca; Marie-Claude Fournié-Zaluski; Bernard P Roques; J L Morgat; J Roy; France Javoy-Agid; Yves Agid
Enkephalin dipeptidyl carboxypeptidase ("enkephalinase"): assay, properties, and distribution in human brain and exploration of the active site.
Advances in biochemical psychopharmacology 1982;33():225-34.
1982: Bernard P Roques; Marie-Claude Fournié-Zaluski; G Gacel; M David; J C Meunier; Bernard Maigret; J L Morgat
Rational design and biological properties of highly specific mu and delta opioid peptides.
Advances in biochemical psychopharmacology 1982;33():321-31.
1981: P Laugaa; A Delbarre; Bernard P Roques
1H NMR studies of the interactions of self-associating intercalating agents with dinucleotides: a theoretical analysis.
Biochimie 1981;63(11-12):967-73.
1981: MC Fournie-Zaluski; G Gacel; Bernard Maigret; S Premilat; Bernard P Roques
Structural requirements for specific recognition of mu or delta opiate receptors.
Molecular pharmacology 1981;20(3):484-91.
1981: G Gacel; Marie-Claude Fournié-Zaluski; E Fellion; Bernard P Roques
Evidence of the preferential involvement of mu receptors in analgesia using enkephalins highly selective for peripheral mu or delta receptors.
Journal of medicinal chemistry 1981;24(10):1119-24.
1981: G Patey; S De La Baume; J C Schwartz; C Gros; Bernard P Roques; MC Fournie-Zaluski; E Soroca-Lucas
Selective protection of methionine enkephalin released from brain slices by enkephalinase inhibition.
Science (New York, N.Y.) 1981;212(4499):1153-5.
1981: Judith Markovits; B Gaugain; J Barbet; Bernard P Roques; J B Le Pecq
Hydrogen bonding in deoxyribonucleic acid base recognition. 2. Deoxyribonucleic acid binding studies of acridine alkylamides.
Biochemistry 1981;20(11):3042-8.
1981: B Gaugain; Judith Markovits; J B Le Pecq; Bernard P Roques
Hydrogen bonding in deoxyribonucleic acid base recognition. 1. Proton nuclear magnetic resonance studies of dinucleotide-acridine alkylamide complexes.
Biochemistry 1981;20(11):3035-42.
1981: Bernard Maigret; S Premilat; MC Fournie-Zaluski; Bernard P Roques
Proposals for conformation of enkephalins related to opiate mu-pharmacophore.
Biochemical and biophysical research communications 1981;99(1):267-74.
1980: D Pelaprat; A Delbarre; I Le Guen; Bernard P Roques; J B Le Pecq
DNA intercalating compounds as potential antitumor agents. 2. Preparation and properties of 7H-pyridocarbazole dimers.
Journal of medicinal chemistry 1980;23(12):1336-43.
1980: Bernard P Roques; Marie-Claude Fournié-Zaluski; E Soroca; J M Lecomte; B Malfroy; C Llorens; J C Schwartz
The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice.
Nature 1980;288(5788):286-8.
1980: C Llorens; G Gacel; J P Swerts; R Perdrisot; MC Fournie-Zaluski; J C Schwartz; Bernard P Roques
Rational design of enkephalinase inhibitors: substrate specificity of enkephalinase studied from inhibitory potency of various dipeptides.
Biochemical and biophysical research communications 1980;96(4):1710-6.
1980: J C Schwartz; S de la Baume; B Malfroy; G Patey; R Perdrisot; J P Swerts; Marie-Claude Fournié-Zaluski; G Gacel; Bernard P Roques
Properties variations and possible synaptic functions of "enkephalinase": a newly characterised dipeptidyl carboxypeptidase.
Advances in biochemical psychopharmacology 1980;22():219-35.
1980: J C Schwartz; S de la Baume; B Malfroy; G Patey; R Perdrisot; J P Swerts; MC Fournie-Zaluski; G Gacel; Bernard P Roques
"Enkephalinase", a newly characterised dipeptidyl carboxypeptidase: properties and possible role in enkephalinergic transmission.
International journal of neurology 1980;14(2-4):195-204.