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Patrik Rorsman

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Anatomy

Physiology

Exocytosis

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Patrik Rorsman; Matthias Braun
Regulation of insulin secretion in human pancreatic islets.
Matthias Braun; R Ramracheya; Patrik Rorsman
Autocrine regulation of insulin secretion.
Anders H Rosengren; Albert Salehi; Makoto Shigeto; Yunzhao Tang; Mary E Travers; Jonathan N Walker; Enming Zhang; Peter Almgren; Sofia A Andersson; Annika S Axelsson; Amy Barrett; Matthias Braun; Anna Edlund; Anna L Gloyn; Leif Groop; Paul R V Johnson; Anna Jonsson; Claes Ladenvall; Valeriya Lyssenko; Taman Mahdi; Mark I McCarthy; Morten Gram Pedersen; Reshma Ramracheya; Erik Renström; Patrik Rorsman; Lena Eliasson
Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes.

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All Publications

2013: Patrik Rorsman; Matthias Braun
Regulation of insulin secretion in human pancreatic islets.
Annual review of physiology 2013;75():155-79.
2012: Matthias Braun; R Ramracheya; Patrik Rorsman
Autocrine regulation of insulin secretion.
Diabetes, obesity & metabolism 2012;14 Suppl 3():143-51.
2012: Anders H Rosengren; Albert Salehi; Makoto Shigeto; Yunzhao Tang; Mary E Travers; Jonathan N Walker; Enming Zhang; Peter Almgren; Sofia A Andersson; Annika S Axelsson; Amy Barrett; Matthias Braun; Anna Edlund; Anna L Gloyn; Leif Groop; Paul R V Johnson; Anna Jonsson; Claes Ladenvall; Valeriya Lyssenko; Taman Mahdi; Mark I McCarthy; Morten Gram Pedersen; Reshma Ramracheya; Erik Renström; Patrik Rorsman; Lena Eliasson
Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes.
Diabetes 2012;61(7):1726-33.
2012: M B Hoppa; E Jones; J Karanauskaite; Patrick E MacDonald; A G Monteith; Reshma Ramracheya; Sebastian Barg; Matthias Braun; A Clark; S C Collins; Lena Eliasson; Juris Galvanovskis; C Genoud; Q Zhang; Patrik Rorsman
Multivesicular exocytosis in rat pancreatic beta cells.
Diabetologia 2012;55(4):1001-12.
2012: Frances M Ashcroft; Patrik Rorsman
Diabetes mellitus and the β cell: the last ten years.
Cell 2012;148(6):1160-71.
2012: Patrik Rorsman; Matthias Braun; Quan Zhang
Regulation of calcium in pancreatic α- and β-cells in health and disease.
Cell calcium 2012;51(3-4):300-8.
2012: Albert Salehi; Inger M E Björck; Ulrika Gunnerud; Jens J Holst; Sarheed J Muhammed; Elin M Ostman; Patrik Rorsman
The insulinogenic effect of whey protein is partially mediated by a direct effect of amino acids and GIP on β-cells.
Nutrition & metabolism 2012;9(1):48.
2011: Patrik Rorsman; Quan Zhang; Lena Eliasson; Takahiro Kanno; Sven Gopel
Electrophysiology of pancreatic β-cells in intact mouse islets of Langerhans.
Progress in biophysics and molecular biology 2011;107(2):224-35.
2011: J N Walker; Q Zhang; Matthias Braun; P R V Johnson; Reshma Ramracheya; Patrik Rorsman
Regulation of glucagon secretion by glucose: paracrine, intrinsic or both?
Diabetes, obesity & metabolism 2011;13 Suppl 1():95-105.
2011: Patrick E MacDonald; Patrik Rorsman
Per-arnt-sim (PAS) domain kinase (PASK) as a regulator of glucagon secretion.
Diabetologia 2011;54(4):719-21.
2011: Juris Galvanovskis; Matthias Braun; Patrik Rorsman
Exocytosis from pancreatic β-cells: mathematical modelling of the exit of low-molecular-weight granule content.
Interface focus 2011;1(1):143-52.
2010: Matthias Braun; Patrik Rorsman
The glucagon-producing alpha cell: an electrophysiologically exceptional cell.
Diabetologia 2010;53(9):1827-30.
2010: Reshma Ramracheya; Caroline Ward; Makoto Shigeto; Jonathan N Walker; Stefan Amisten; Quan Zhang; Paul R Johnson; Patrik Rorsman; Matthias Braun
Membrane potential-dependent inactivation of voltage-gated ion channels in alpha-cells inhibits glucagon secretion from human islets.
Diabetes 2010;59(9):2198-208.
2010: Rebecca H Clark; James S McTaggart; Richard Webster; Roope Mannikko; Michaela Iberl; Xiu Li Sim; Patrik Rorsman; Maike Glitsch; David Beeson; Frances M Ashcroft
Muscle dysfunction caused by a KATP channel mutation in neonatal diabetes is neuronal in origin.
Science (New York, N.Y.) 2010;329(5990):458-61.
2010: Matthias Braun; Reshma Ramracheya; Martin Bengtsson; Anne Clark; Jonathan N Walker; Paul R Johnson; Patrik Rorsman
Gamma-aminobutyric acid (GABA) is an autocrine excitatory transmitter in human pancreatic beta-cells.
Diabetes 2010;59(7):1694-701.
2010: Yang Z De Marinis; Albert Salehi; Caroline E Ward; Quan Zhang; Fernando Abdulkader; Martin Bengtsson; Orit Braha; Matthias Braun; Reshma Ramracheya; Stefan Amisten; Abdella M Habib; Yusuke Moritoh; Enming Zhang; Frank Reimann; Anders H Rosengren; Tadao Shibasaki; Fiona Gribble; Erik Renström; Susumu Seino; Lena Eliasson; Patrik Rorsman
GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis.
Cell metabolism 2010;11(6):543-53.
2010: Stephan C Collins; Michael B Hoppa; Jonathan N Walker; Stefan Amisten; Fernando Abdulkader; Martin Bengtsson; Jane Fearnside; Reshma Ramracheya; Ayo TOYE; Quan Zhang; Anne Clark; Dominique Gauguier; Patrik Rorsman
Progression of diet-induced diabetes in C57BL6J mice involves functional dissociation of Ca2(+) channels from secretory vesicles.
Diabetes 2010;59(5):1192-201.
2010: Y Z De Marinis; E Zhang; Stefan Amisten; Jalal Taneera; Erik Renström; Patrik Rorsman; Lena Eliasson
Enhancement of glucagon secretion in mouse and human pancreatic alpha cells by protein kinase C (PKC) involves intracellular trafficking of PKCalpha and PKCdelta.
Diabetologia 2010;53(4):717-29.
2010: Anders H Rosengren; Ramunas Jokubka; Damon Tojjar; Charlotte Granhall; Ola Hansson; Dai-Qing Li; Vini Nagaraj; Thomas M Reinbothe; Jonatan Tuncel; Lena Eliasson; Leif Groop; Patrik Rorsman; Albert Salehi; Valeriya Lyssenko; Holger Luthman; Erik Renström
Overexpression of alpha2A-adrenergic receptors contributes to type 2 diabetes.
Science (New York, N.Y.) 2010;327(5962):217-20.
2010: Stefanie Obermüller; Federico Calegari; Angus King; Anders Lindqvist; Ingmar Lundquist; Albert Salehi; Maura Francolini; Patrizia Rosa; Patrik Rorsman; Wieland B Huttner; Sebastian Barg
Defective secretion of islet hormones in chromogranin-B deficient mice.
PloS one 2010;5(1):e8936.
2009: Michael B Hoppa; Stephan Collins; Reshma Ramracheya; Leanne Hodson; Stefan Amisten; Quan Zhang; Paul Johnson; Frances M Ashcroft; Patrik Rorsman
Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca(2+) channels from secretory granules.
Cell metabolism 2009;10(6):455-65.
2009: Sabina Santesson; Eva Degerman; Patrik Rorsman; Thomas Johansson; Sandra Lemos; Staffan Nilsson
Cell-cell communication between adipocytes and pancreatic beta-cells in acoustically levitated droplets.
Integrative biology : quantitative biosciences from nano to macro 2009;1(10):595-601.
2009: Dai-Qing Li; Xingjun Jing; Albert Salehi; Stephan C Collins; Michael B Hoppa; Anders H Rosengren; Enming Zhang; Ingmar Lundquist; Charlotta S Olofsson; Matthias Mörgelin; Lena Eliasson; Patrik Rorsman; Erik Renström
Suppression of sulfonylurea- and glucose-induced insulin secretion in vitro and in vivo in mice lacking the chloride transport protein ClC-3.
Cell metabolism 2009;10(4):309-15.
2009: Siân E Williams; Anita A C Reed; Juris Galvanovskis; Corinne Antignac; Tim Goodship; Fiona E Karet; Peter Kotanko; Karl Lhotta; Vincent Morinière; Paul Williams; William Wong; Patrik Rorsman; Rajesh V Thakker
Uromodulin mutations causing familial juvenile hyperuricaemic nephropathy lead to protein maturation defects and retention in the endoplasmic reticulum.
Human molecular genetics 2009;18(16):2963-74.
2009: Matthias Braun; Reshma Ramracheya; Stefan Amisten; Martin Bengtsson; Y Moritoh; Q Zhang; Paul R V Johnson; Patrik Rorsman
Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells.
Diabetologia 2009;52(8):1566-78.
2009: Charlotta S Olofsson; Joakim Håkansson; Albert Salehi; Martin Bengtsson; Juris Galvanovskis; Chris Partridge; Maria SörhedeWinzell; Xiaojie Xian; Lena Eliasson; Ingmar Lundquist; Henrik Semb; Patrik Rorsman
Impaired insulin exocytosis in neural cell adhesion molecule-/- mice due to defective reorganization of the submembrane F-actin network.
Endocrinology 2009;150(7):3067-75.
2009: Jovita Karanauskaite; Michael B Hoppa; Matthias Braun; Juris Galvanovskis; Patrik Rorsman
Quantal ATP release in rat beta-cells by exocytosis of insulin-containing LDCVs.
Pflügers Archiv : European journal of physiology 2009;458(2):389-401.
2009: Matthew N Poy; Jean Hausser; Mirko Trajkovski; Matthias Braun; Stephan Collins; Patrik Rorsman; Mihaela Zavolan; Markus Stoffel
miR-375 maintains normal pancreatic alpha- and beta-cell mass.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(14):5813-8.
2009: Salma T Hanna; Gary M Pigeau; Juris Galvanovskis; Anne Clark; Patrik Rorsman; Patrick E MacDonald
Kiss-and-run exocytosis and fusion pores of secretory vesicles in human beta-cells.
Pflügers Archiv : European journal of physiology 2009;457(6):1343-50.
2009: Ulrika E A Mårtensson; S Albert Salehi; Sara Windahl; Maria F Gomez; Karl Swärd; Joanna Daszkiewicz-Nilsson; Anna Wendt; Niklas Andersson; Per Hellstrand; Per-Olof Grände; Christer Owman; Clifford J Rosen; Martin Adamo; Ingmar Lundquist; Patrik Rorsman; Bengt-Olof Nilsson; Claes Ohlsson; Björn Olde; L M Fredrik Leeb-Lundberg
Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice.
Endocrinology 2009;150(2):687-98.
2009: Grzegorz Sumara; Ivan Formentini; Stephan Collins; Izabela Sumara; Renata Windak; Bernd Bodenmiller; Reshma Ramracheya; Dorothée Caille; Huiping Jiang; Kenneth A Platt; Paolo Meda; Rudolf Aebersold; Patrik Rorsman; Romeo Ricci
Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis.
Cell 2009;136(2):235-48.
2009: Matthias Braun; Reshma Ramracheya; Paul R Johnson; Patrik Rorsman
Exocytotic properties of human pancreatic beta-cells.
Annals of the New York Academy of Sciences 2009;1152():187-93.
2009: Christophe A Girard; F Thomas Wunderlich; Kenju Shimomura; Stephan Collins; Stephan Kaizik; Peter Proks; Fernando Abdulkader; Anne Clark; Vicky Ball; Lejla Zubcevic; Liz Bentley; Rebecca Clark; Chris Church; Alison Hugill; Juris Galvanovskis; Roger Cox; Patrik Rorsman; Jens C Brüning; Frances M Ashcroft
Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes.
The Journal of clinical investigation 2009;119(1):80-90.
2008: Jens Zehetner; Carsten Danzer; Stephan Collins; Katrin Eckhardt; Philipp A Gerber; Pia Ballschmieter; Juris Galvanovskis; Kenju Shimomura; Frances M Ashcroft; Bernard Thorens; Patrik Rorsman; Wilhelm Krek
PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells.
Genes & development 2008;22(22):3135-46.
2008: Quan Zhang; Juris Galvanovskis; Fernando Abdulkader; Christopher J Partridge; Sven O Göpel; Lena Eliasson; Patrik Rorsman
Cell coupling in mouse pancreatic beta-cells measured in intact islets of Langerhans.
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences 2008;366(1880):3503-23.
2008: Patrik Rorsman; S Albert Salehi; Fernando Abdulkader; Matthias Braun; Patrick E MacDonald
K(ATP)-channels and glucose-regulated glucagon secretion.
Trends in endocrinology and metabolism: TEM 2008;19(8):277-84.
2008: S C Collins; A Salehi; L Eliasson; C S Olofsson; Patrik Rorsman
Long-term exposure of mouse pancreatic islets to oleate or palmitate results in reduced glucose-induced somatostatin and oversecretion of glucagon.
Diabetologia 2008;51(9):1689-93.
2008: Lena Eliasson; Fernando Abdulkader; Matthias Braun; Juris Galvanovskis; Michael B Hoppa; Patrik Rorsman
Novel aspects of the molecular mechanisms controlling insulin secretion.
The Journal of physiology 2008;586(14):3313-24.
2008: Matthias Braun; Reshma Ramracheya; Martin Bengtsson; Quan Zhang; Jovita Karanauskaite; Christopher J Partridge; Paul R V Johnson; Patrik Rorsman
Voltage-gated ion channels in human pancreatic beta-cells: electrophysiological characterization and role in insulin secretion.
Diabetes 2008;57(6):1618-28.
2008: Robert H Wallis; Stephan C Collins; Pamela J Kaisaki; Karène Argoud; Steven P Wilder; Karin J Wallace; Massimiliano Ria; Alain Ktorza; Patrik Rorsman; Marie-Thérèse Bihoreau; Dominique Gauguier
Pathophysiological, genetic and gene expression features of a novel rodent model of the cardio-metabolic syndrome.
PloS one 2008;3(8):e2962.
2008: Martin Bengtsson; Martin Hemberg; Patrik Rorsman; Anders Ståhlberg
Quantification of mRNA in single cells and modelling of RT-qPCR induced noise.
BMC molecular biology 2008;9():63.
2008: Dina Speidel; Albert Salehi; Stefanie Obermueller; Ingmar Lundquist; Nils Brose; Erik Renström; Patrik Rorsman
CAPS1 and CAPS2 regulate stability and recruitment of insulin granules in mouse pancreatic beta cells.
Cell metabolism 2008;7(1):57-67.
2007: Thomas Gerken; Christophe A Girard; Yi-Chun Loraine Tung; Celia J Webby; Vladimir Saudek; Kirsty S Hewitson; Giles S H Yeo; Michael McDonough; Sharon Cunliffe; Luke A McNeill; Juris Galvanovskis; Patrik Rorsman; Peter Robins; Xavier Prieur; Anthony P Coll; Marcella Ma; Zorica Jovanovic; I Sadaf Farooqi; Barbara Sedgwick; Inês Barroso; Tomas Lindahl; Chris P Ponting; Frances M Ashcroft; Stephen O'Rahilly; Christopher J Schofield
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.
Science (New York, N.Y.) 2007;318(5855):1469-72.
2007: Charlotta S Olofsson; Stephan Collins; Martin Bengtsson; Lena Eliasson; Albert Salehi; Kenju Shimomura; Andrei Tarasov; Cecilia Holm; Frances Ashcroft; Patrik Rorsman
Long-term exposure to glucose and lipids inhibits glucose-induced insulin secretion downstream of granule fusion with plasma membrane.
Diabetes 2007;56(7):1888-97.
2007: Patrick E MacDonald; Yang Zhang De Marinis; Reshma Ramracheya; Albert Salehi; Xiaosong Ma; Paul R V Johnson; Roger Cox; Lena Eliasson; Patrik Rorsman
A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans.
PLoS biology 2007;5(6):e143.
2007: Patrick E MacDonald; Patrik Rorsman
The ins and outs of secretion from pancreatic beta-cells: control of single-vesicle exo- and endocytosis.
Physiology (Bethesda, Md.) 2007;22():113-21.
2007: Quan Zhang; Martin Bengtsson; Christopher J Partridge; Albert Salehi; Matthias Braun; Roger Cox; Lena Eliasson; Paul R V Johnson; Erik Renström; Toni Schneider; Per-Olof Berggren; Sven Göpel; Frances M Ashcroft; Patrik Rorsman
R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion.
Nature cell biology 2007;9(4):453-60.
2007: Matthias Braun; Anna Wendt; Jovita Karanauskaite; Juris Galvanovskis; Anne Clark; Patrick E MacDonald; Patrik Rorsman
Corelease and differential exit via the fusion pore of GABA, serotonin, and ATP from LDCV in rat pancreatic beta cells.
The Journal of general physiology 2007;129(3):221-31.
2007: Alexander Jeans; Peter L Oliver; Reuben Johnson; Marco Capogna; Jenny Vikman; Zoltán Molnár; Arran Babbs; Christopher J Partridge; Albert Salehi; Martin Bengtsson; Lena Eliasson; Patrik Rorsman; Kay E Davies
A dominant mutation in Snap25 causes impaired vesicle trafficking, sensorimotor gating, and ataxia in the blind-drunk mouse.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(7):2431-6.
2006: Patrick E MacDonald; Matthias Braun; Juris Galvanovskis; Patrik Rorsman
Release of small transmitters through kiss-and-run fusion pores in rat pancreatic beta cells.
Cell metabolism 2006;4(4):283-90.
2006: Jenny Vikman; Xiaosong Ma; Gregory H Hockerman; Patrik Rorsman; Lena Eliasson
Antibody inhibition of synaptosomal protein of 25 kDa (SNAP-25) and syntaxin 1 reduces rapid exocytosis in insulin-secreting cells.
Journal of molecular endocrinology 2006;36(3):503-15.
2006: Patrick E MacDonald; Patrik Rorsman
Oscillations, intercellular coupling, and insulin secretion in pancreatic beta cells.
PLoS biology 2006;4(2):e49.
2005: Patrick E MacDonald; Jamie W Joseph; Patrik Rorsman
Glucose-sensing mechanisms in pancreatic beta-cells.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2005;360(1464):2211-25.
2005: Patrick E MacDonald; Lena Eliasson; Patrik Rorsman
Calcium increases endocytotic vesicle size and accelerates membrane fission in insulin-secreting INS-1 cells.
Journal of cell science 2005;118(Pt 24):5911-20.
2005: Stefanie Obermüller; Anders Lindqvist; Jovita Karanauskaite; Juris Galvanovskis; Patrik Rorsman; Sebastian Barg
Selective nucleotide-release from dense-core granules in insulin-secreting cells.
Journal of cell science 2005;118(Pt 18):4271-82.
2005: Patrick E MacDonald; Stefanie Obermüller; Jenny Vikman; Juris Galvanovskis; Patrik Rorsman; Lena Eliasson
Regulated exocytosis and kiss-and-run of synaptic-like microvesicles in INS-1 and primary rat beta-cells.
Diabetes 2005;54(3):736-43.
2005: Xingjun Jing; Dai-Qing Li; Charlotta S Olofsson; Albert Salehi; Vikas V Surve; José Caballero; Rosita Ivarsson; Ingmar Lundquist; Alexey Pereverzev; Toni Schneider; Patrik Rorsman; Erik Renström
CaV2.3 calcium channels control second-phase insulin release.
The Journal of clinical investigation 2005;115(1):146-54.
2005: Xiaosong Ma; Yang Zhang; Jesper Gromada; Sabine Sewing; Per-Olof Berggren; Karsten Buschard; Albert Salehi; Jenny Vikman; Patrik Rorsman; Lena Eliasson
Glucagon stimulates exocytosis in mouse and rat pancreatic alpha-cells by binding to glucagon receptors.
Molecular endocrinology (Baltimore, Md.) 2005;19(1):198-212.
2004: Sebastian Barg; Patrik Rorsman
Insulin secretion: a high-affinity Ca2+ sensor after all?
The Journal of general physiology 2004;124(6):623-5.
2004: Jesper Gromada; Xiaosong Ma; Marianne Høy; Krister Bokvist; Albert Salehi; Per-Olof Berggren; Patrik Rorsman
ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical activity by glucose in wild-type and SUR1-/- mouse alpha-cells.
Diabetes 2004;53 Suppl 3():S181-9.
2004: Matthew N Poy; Lena Eliasson; Jan Krutzfeldt; Satoru Kuwajima; Xiaosong Ma; Patrick E MacDonald; Sébastien Pfeffer; Thomas Tuschl; Nikolaus Rajewsky; Patrik Rorsman; Markus Stoffel
A pancreatic islet-specific microRNA regulates insulin secretion.
Nature 2004;432(7014):226-30.
2004: Charlotta S Olofsson; Albert Salehi; Sven Göpel; Cecilia Holm; Patrik Rorsman
Palmitate stimulation of glucagon secretion in mouse pancreatic alpha-cells results from activation of L-type calcium channels and elevation of cytoplasmic calcium.
Diabetes 2004;53(11):2836-43.
2004: Matthias Braun; Anna Wendt; Karsten Buschard; Albert Salehi; Sabine Sewing; Jesper Gromada; Patrik Rorsman
GABAB receptor activation inhibits exocytosis in rat pancreatic beta-cells by G-protein-dependent activation of calcineurin.
The Journal of physiology 2004;559(Pt 2):397-409.
2004: Takahiro Kanno; Xiasong Ma; Sebastian Barg; Lena Eliasson; Juris Galvanovskis; Sven Göpel; Max Larsson; Erik Renström; Patrik Rorsman
Large dense-core vesicle exocytosis in pancreatic beta-cells monitored by capacitance measurements.
Methods (San Diego, Calif.) 2004;33(4):302-11.
2004: Malin Fex; Charlotta S Olofsson; Ulrika Fransson; Karl Bacos; Håkan Lindvall; Maria Sörhede-Winzell; Patrik Rorsman; Cecilia Holm; Hindrik Mulder
Hormone-sensitive lipase deficiency in mouse islets abolishes neutral cholesterol ester hydrolase activity but leaves lipolysis, acylglycerides, fat oxidation, and insulin secretion intact.
Endocrinology 2004;145(8):3746-53.
2004: Karin Hansson; Xiaosong Ma; Lena Eliasson; Eva Czerwiec; Bruce Furie; Barbara C Furie; Patrik Rorsman; Johan Stenflo
The first gamma-carboxyglutamic acid-containing contryphan. A selective L-type calcium ion channel blocker isolated from the venom of Conus marmoreus.
The Journal of biological chemistry 2004;279(31):32453-63.
2004: Charlotta S Olofsson; Albert Salehi; Cecilia Holm; Patrik Rorsman
Palmitate increases L-type Ca2+ currents and the size of the readily releasable granule pool in mouse pancreatic beta-cells.
The Journal of physiology 2004;557(Pt 3):935-48.
2004: martina Sinnegger-Brauns; Alfred Hetzenauer; Irene G Huber; Erik Renström; Georg Wietzorrek; Stanislav Berjukov; Maurizio Cavalli; Doris Walter; alexandra koschak; Ralph Waldschütz; Steffen Hering; Sergio Bova; Patrik Rorsman; Olaf Pongs; Nicolas Singewald; J öRg Striessnig J
Isoform-specific regulation of mood behavior and pancreatic beta cell and cardiovascular function by L-type Ca 2+ channels.
The Journal of clinical investigation 2004;113(10):1430-9.
2004: Frances M Ashcroft; Patrik Rorsman
Molecular defects in insulin secretion in type-2 diabetes.
Reviews in endocrine & metabolic disorders 2004;5(2):135-42.
2004: Sven Göpel; Quan Zhang; Lena Eliasson; Xiao-Song Ma; Juris Galvanovskis; Takahiro Kanno; Albert Salehi; Patrik Rorsman
Capacitance measurements of exocytosis in mouse pancreatic alpha-, beta- and delta-cells within intact islets of Langerhans.
The Journal of physiology 2004;556(Pt 3):711-26.
2004: Anna Wendt; Bryndis Birnir; Karsten Buschard; Jesper Gromada; Albert Salehi; Sabine Sewing; Patrik Rorsman; Matthias Braun
Glucose inhibition of glucagon secretion from rat alpha-cells is mediated by GABA released from neighboring beta-cells.
Diabetes 2004;53(4):1038-45.
2004: Frances M Ashcroft; Patrik Rorsman
Type 2 diabetes mellitus: not quite exciting enough?
Human molecular genetics 2004;13 Spec No 1():R21-31.
2004: Matthias Braun; Anna Wendt; Bryndis Birnir; Jonas Broman; Lena Eliasson; Juris Galvanovskis; Jesper Gromada; Hindrik Mulder; Patrik Rorsman
Regulated exocytosis of GABA-containing synaptic-like microvesicles in pancreatic beta-cells.
The Journal of general physiology 2004;123(3):191-204.
2003: Verena Schulla; Erik Renström; Robert Feil; Susanne Feil; Isobel Franklin; Asllan Gjinovci; Xing-Jun Jing; Dirk Laux; Ingmar Lundquist; Mark Magnuson; Stefanie Obermüller; Charlotta S Olofsson; Albert Salehi; Anna Wendt; Norbert Klugbauer; Claes B Wollheim; Patrik Rorsman; Franz Hofmann
Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice.
The EMBO journal 2003;22(15):3844-54.
2003: Patrik Rorsman; Erik Renström
Insulin granule dynamics in pancreatic beta cells.
Diabetologia 2003;46(8):1029-45.
2003: Hervør L Olsen; Marianne Hoy; Wei Zhang; Alejandro M Bertorello; Krister Bokvist; Kirsten Capito; Alexander M Efanov; Björn Meister; Peter Thams; Shao-Nian Yang; Patrik Rorsman; Per-Olof Berggren; Jesper Gromada
Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic beta cells.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5187-92.
2003: Marianne Høy; Hervør L Olsen; Henrik Sune Andersen; Krister Bokvist; Karsten Buschard; John Hansen; Palle Jacobsen; Jacob S Petersen; Patrik Rorsman; Jesper Gromada
Imidazoline NNC77-0074 stimulates insulin secretion and inhibits glucagon release by control of Ca(2+)-dependent exocytosis in pancreatic alpha- and beta-cells.
European journal of pharmacology 2003;466(1-2):213-21.
2003: Lena Eliasson; Xiaosong Ma; Erik Renström; Sebastian Barg; Per-Olof Berggren; Juris Galvanovskis; Jesper Gromada; Xingjun Jing; Ingmar Lundquist; Albert Salehi; Sabine Sewing; Patrik Rorsman
SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells.
The Journal of general physiology 2003;121(3):181-97.
2002: Takahiro Kanno; Patrik Rorsman; Sven Göpel
Glucose-dependent regulation of rhythmic action potential firing in pancreatic beta-cells by K(ATP)-channel modulation.
The Journal of physiology 2002;545(Pt 2):501-7.
2002: Jesper Gromada; Krister Bokvist; Marianne Høy; Hervør L Olsen; Per Lindström; Birgit S Hansen; Carsten F Gotfredsen; Patrik Rorsman; Mads Krogsgaard Thomsen
Nateglinide, but not repaglinide, stimulates growth hormone release in rat pituitary cells by inhibition of K channels and stimulation of cyclic AMP-dependent exocytosis.
European journal of endocrinology / European Federation of Endocrine Societies 2002;147(1):133-42.
2002: Charlotta S Olofsson; Sven Göpel; Sebastian Barg; Juris Galvanovskis; Xiaosong Ma; Albert Salehi; Patrik Rorsman; Lena Eliasson
Fast insulin secretion reflects exocytosis of docked granules in mouse pancreatic B-cells.
Pflügers Archiv : European journal of physiology 2002;444(1-2):43-51.
2002: Takahiro Kanno; Sven O Gopel; Patrik Rorsman; Makoto Wakui
Cellular function in multicellular system for hormone-secretion: electrophysiological aspect of studies on alpha-, beta- and delta-cells of the pancreatic islet.
Neuroscience research 2002;42(2):79-90.
2002: Sebastian Barg; Lena Eliasson; Erik Renström; Patrik Rorsman
A subset of 50 secretory granules in close contact with L-type Ca2+ channels accounts for first-phase insulin secretion in mouse beta-cells.
Diabetes 2002;51 Suppl 1():S74-82.
2002: Erik Renström; Sebastian Barg; Frank Thévenod; Patrik Rorsman
Sulfonylurea-mediated stimulation of insulin exocytosis via an ATP-sensitive K+ channel-independent action.
Diabetes 2002;51 Suppl 1():S33-6.
2002: Sebastian Barg; Charlotta S Olofsson; Jenny Schriever-Abeln; Anna Wendt; Samuel Gebre-Medhin; Erik Renström; Patrik Rorsman
Delay between fusion pore opening and peptide release from large dense-core vesicles in neuroendocrine cells.
Neuron 2002;33(2):287-99.
2001: Sebastian Barg; Xiaosong Ma; Lena Eliasson; Juris Galvanovskis; Sven Göpel; Stefanie Obermüller; Josef Platzer; Erik Renström; Michael Trus; Daphne Atlas; J Striessnig; Patrik Rorsman
Fast exocytosis with few Ca(2+) channels in insulin-secreting mouse pancreatic B cells.
Biophysical journal 2001;81(6):3308-23.
2001: Jesper Gromada; Marianne Høy; Karsten Buschard; A Salehi; Patrik Rorsman
Somatostatin inhibits exocytosis in rat pancreatic alpha-cells by G(i2)-dependent activation of calcineurin and depriming of secretory granules.
The Journal of physiology 2001;535(Pt 2):519-32.
2001: Sebastian Barg; P Huang; Lena Eliasson; D J Nelson; Stefanie Obermüller; Patrik Rorsman; Frank Thévenod; Erik Renström
Priming of insulin granules for exocytosis by granular Cl(-) uptake and acidification.
Journal of cell science 2001;114(Pt 11):2145-54.
2001: Jesper Gromada; Marianne Høy; Hervør L Olsen; Carsten F Gotfredsen; Karsten Buschard; Patrik Rorsman; Krister Bokvist
Gi2 proteins couple somatostatin receptors to low-conductance K+ channels in rat pancreatic alpha-cells.
Pflügers Archiv : European journal of physiology 2001;442(1):19-26.
2001: Gerd Larsson-Nyrén; Janove Sehlin; Patrik Rorsman; Erik Renström
Perchlorate stimulates insulin secretion by shifting the gating of L-type Ca2+ currents in mouse pancreatic B-cells towards negative potentials.
Pflügers Archiv : European journal of physiology 2001;441(5):587-95.
2000: Sven Göpel; Takahiro Kanno; Sebastian Barg; X G Weng; Jesper Gromada; Patrik Rorsman
Regulation of glucagon release in mouse -cells by KATP channels and inactivation of TTX-sensitive Na+ channels.
The Journal of physiology 2000;528(Pt 3):509-20.
2000: Sven Göpel; Takahiro Kanno; Sebastian Barg; Patrik Rorsman
Patch-clamp characterisation of somatostatin-secreting -cells in intact mouse pancreatic islets.
The Journal of physiology 2000;528(Pt 3):497-507.
2000: Sebastian Barg; Juris Galvanovskis; Sven Göpel; Patrik Rorsman; Lena Eliasson
Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting alpha-cells.
Diabetes 2000;49(9):1500-10.
2000: Marianne Høy; Hervør L Olsen; Krister Bokvist; Karsten Buschard; Sebastian Barg; Patrik Rorsman; Jesper Gromada
Tolbutamide stimulates exocytosis of glucagon by inhibition of a mitochondrial-like ATP-sensitive K+ (KATP) conductance in rat pancreatic A-cells.
The Journal of physiology 2000;527 Pt 1():109-20.
2000: Krister Bokvist; M Holmqvist; Jesper Gromada; Patrik Rorsman
Compound exocytosis in voltage-clamped mouse pancreatic beta-cells revealed by carbon fibre amperometry.
Pflügers Archiv : European journal of physiology 2000;439(5):634-45.
1999: Sven Göpel; Takahiro Kanno; Sebastian Barg; Juris Galvanovskis; Patrik Rorsman
Voltage-gated and resting membrane currents recorded from B-cells in intact mouse pancreatic islets.
The Journal of physiology 1999;521 Pt 3():717-28.
1999: Patrik Rorsman; Erik Renström
Cell biology. Glutamate primes the pump.
Nature 1999;402(6762):595-6.
1999: Sven Göpel; Takahiro Kanno; Sebastian Barg; Lena Eliasson; Juris Galvanovskis; Erik Renström; Patrik Rorsman
Activation of Ca(2+)-dependent K(+) channels contributes to rhythmic firing of action potentials in mouse pancreatic beta cells.
The Journal of general physiology 1999;114(6):759-70.
1999: Krister Bokvist; Hervør L Olsen; Marianne Høy; Carsten F Gotfredsen; W F Holmes; Karsten Buschard; Patrik Rorsman; Jesper Gromada
Characterisation of sulphonylurea and ATP-regulated K+ channels in rat pancreatic A-cells.
Pflügers Archiv : European journal of physiology 1999;438(4):428-36.
1999: Jesper Gromada; Marianne Høy; Erik Renström; Krister Bokvist; Lena Eliasson; Sven Göpel; Patrik Rorsman
CaM kinase II-dependent mobilization of secretory granules underlies acetylcholine-induced stimulation of exocytosis in mouse pancreatic B-cells.
The Journal of physiology 1999;518 ( Pt 3)():745-59.
1999: Sebastian Barg; Erik Renström; Per-Olof Berggren; Alejandro M Bertorello; Krister Bokvist; M Braun; Lena Eliasson; W E Holmes; M Köhler; Patrik Rorsman; Frank Thévenod
The stimulatory action of tolbutamide on Ca2+-dependent exocytosis in pancreatic beta cells is mediated by a 65-kDa mdr-like P-glycoprotein.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(10):5539-44.
1999: David Gall; Jesper Gromada; Isabella Susa; Patrik Rorsman; André Herchuelz; Krister Bokvist
Significance of Na/Ca exchange for Ca2+ buffering and electrical activity in mouse pancreatic beta-cells.
Biophysical journal 1999;76(4):2018-28.
1999: Ofer Wiser; Michael Trus; A Hernández; Erik Renström; Sebastian Barg; Patrik Rorsman; Daphne Atlas
The voltage sensitive Lc-type Ca2+ channel is functionally coupled to the exocytotic machinery.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(1):248-53.
1999: Hindrik Mulder; Lena Stenson Holst; Håkan Svensson; Eva Degerman; Frank Sundler; Bo Ahrén; Patrik Rorsman; Cecilia Holm
Hormone-sensitive lipase, the rate-limiting enzyme in triglyceride hydrolysis, is expressed and active in beta-cells.
Diabetes 1999;48(1):228-32.
1998: Jesper Gromada; Jens Juul Holst; Patrik Rorsman
Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1.
Pflügers Archiv : European journal of physiology 1998;435(5):583-94.
1998: Jesper Gromada; Krister Bokvist; WG Ding; Jens Juul Holst; Jens H Nielsen; Patrik Rorsman
Glucagon-like peptide 1 (7-36) amide stimulates exocytosis in human pancreatic beta-cells by both proximal and distal regulatory steps in stimulus-secretion coupling.
Diabetes 1998;47(1):57-65.
1997: Lena Eliasson; Erik Renström; WG Ding; P Proks; Patrik Rorsman
Rapid ATP-dependent priming of secretory granules precedes Ca(2+)-induced exocytosis in mouse pancreatic B-cells.
The Journal of physiology 1997;503 ( Pt 2)():399-412.
1997: Jesper Gromada; Krister Bokvist; WG Ding; Sebastian Barg; Karsten Buschard; Erik Renström; Patrik Rorsman
Adrenaline stimulates glucagon secretion in pancreatic A-cells by increasing the Ca2+ current and the number of granules close to the L-type Ca2+ channels.
The Journal of general physiology 1997;110(3):217-28.
1997: Jesper Gromada; WG Ding; Sebastian Barg; Erik Renström; Patrik Rorsman
Multisite regulation of insulin secretion by cAMP-increasing agonists: evidence that glucagon-like peptide 1 and glucagon act via distinct receptors.
Pflügers Archiv : European journal of physiology 1997;434(5):515-24.
1997: Erik Renström; Lena Eliasson; Patrik Rorsman
Protein kinase A-dependent and -independent stimulation of exocytosis by cAMP in mouse pancreatic B-cells.
The Journal of physiology 1997;502 ( Pt 1)():105-18.
1997: Patrik Rorsman
The pancreatic beta-cell as a fuel sensor: an electrophysiologist's viewpoint.
Diabetologia 1997;40(5):487-95.
1997: WG Ding; Erik Renström; Patrik Rorsman; Karsten Buschard; Jesper Gromada
Glucagon-like peptide I and glucose-dependent insulinotropic polypeptide stimulate Ca2+-induced secretion in rat alpha-cells by a protein kinase A-mediated mechanism.
Diabetes 1997;46(5):792-800.
1997: Patrik Rorsman; Lena Eliasson; Erik Renström
Components of insulin secretion: lessons to be learnt from capacitance.
The Japanese journal of physiology 1997;47 Suppl 1():S21.
1996: Peter Proks; Lena Eliasson; C Ammälä; Patrik Rorsman; F M Ashcroft
Ca(2+)- and GTP-dependent exocytosis in mouse pancreatic beta-cells involves both common and distinct steps.
The Journal of physiology 1996;496 ( Pt 1)():255-64.
1996: Erik Renström; WG Ding; Krister Bokvist; Patrik Rorsman
Neurotransmitter-induced inhibition of exocytosis in insulin-secreting beta cells by activation of calcineurin.
Neuron 1996;17(3):513-22.
1996: Jesper Gromada; Patrik Rorsman
Molecular mechanism underlying glucagon-like peptide 1 induced calcium mobilization from internal stores in insulin-secreting beta TC3 cells.
Acta physiologica Scandinavica 1996;157(3):349-51.
1996: Erik Renström; Lena Eliasson; Krister Bokvist; Patrik Rorsman
Cooling inhibits exocytosis in single mouse pancreatic B-cells by suppression of granule mobilization.
The Journal of physiology 1996;494 ( Pt 1)():41-52.
1996: Lena Eliasson; Peter Proks; C Ammälä; F M Ashcroft; Krister Bokvist; Erik Renström; Patrik Rorsman; P A Smith
Endocytosis of secretory granules in mouse pancreatic beta-cells evoked by transient elevation of cytosolic calcium.
The Journal of physiology 1996;493 ( Pt 3)():755-67.
1996: Jesper Gromada; Steen Dissing; Patrik Rorsman
Desensitization of glucagon-like peptide 1 receptors in insulin-secreting beta TC3 cells: role of PKA-independent mechanisms.
British journal of pharmacology 1996;118(3):769-75.
1996: Lena Eliasson; Erik Renström; C Ammälä; Per-Olof Berggren; A M Bertorello; Krister Bokvist; Alexander V Chibalin; Jude T Deeney; P R Flatt; J Gäbel; Jesper Gromada; Olof Larsson; P Lindström; Christopher J Rhodes; Patrik Rorsman
PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic beta cells.
Science (New York, N.Y.) 1996;271(5250):813-5.
1996: Willy J Malaisse; P Lebrun; B Pirotte; P D Van Poelje; C Viñambres; María L Villanueva-Peñacarrillo; Isabel Valverde; J Gäbel; Patrik Rorsman
The riddle of formycin A insulinotropic action.
Biochemical and molecular medicine 1996;57(1):47-63.
1996: Philippe Lebrun; Erik Renström; Marie-Hélène Antoine; Krister Bokvist; M Holmquist; Patrik Rorsman; W J Malaisse
Dynamics of the cationic, bioelectrical and secretory responses to formycin A in pancreatic islet cells.
Pflügers Archiv : European journal of physiology 1996;431(3):353-62.
1995: Jesper Gromada; Patrik Rorsman; Steen Dissing; Birgitte S Wulff
Stimulation of cloned human glucagon-like peptide 1 receptor expressed in HEK 293 cells induces cAMP-dependent activation of calcium-induced calcium release.
FEBS letters 1995;373(2):182-6.
1995: Jesper Gromada; Steen Dissing; Krister Bokvist; Erik Renström; J Frøkjaer-Jensen; Birgitte S Wulff; Patrik Rorsman
Glucagon-like peptide I increases cytoplasmic calcium in insulin-secreting beta TC3-cells by enhancement of intracellular calcium mobilization.
Diabetes 1995;44(7):767-74.
1995: Krister Bokvist; Lena Eliasson; C Ammälä; Erik Renström; Patrik Rorsman
Co-localization of L-type Ca2+ channels and insulin-containing secretory granules and its significance for the initiation of exocytosis in mouse pancreatic B-cells.
The EMBO journal 1995;14(1):50-7.
1994: C Ammälä; Lena Eliasson; Krister Bokvist; Per-Olof Berggren; R E Honkanen; A Sjöholm; Patrik Rorsman
Activation of protein kinases and inhibition of protein phosphatases play a central role in the regulation of exocytosis in mouse pancreatic beta cells.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(10):4343-7.
1994: F M Ashcroft; Peter Proks; P A Smith; C Ammälä; Krister Bokvist; Patrik Rorsman
Stimulus-secretion coupling in pancreatic beta cells.
Journal of cellular biochemistry 1994;55 Suppl():54-65.
1993: C Ammälä; Lena Eliasson; Krister Bokvist; Olof Larsson; F M Ashcroft; Patrik Rorsman
Exocytosis elicited by action potentials and voltage-clamp calcium currents in individual mouse pancreatic B-cells.
The Journal of physiology 1993;472():665-88.
1993: A Sjöholm; P Arkhammar; Nils Welsh; Krister Bokvist; Patrik Rorsman; A Hallberg; T Nilsson; Michael Welsh; Per-Olof Berggren
Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity.
The Journal of clinical investigation 1993;92(4):1910-7.
1993: L Juntti-Berggren; Olof Larsson; Patrik Rorsman; C Ammälä; Krister Bokvist; K Wåhlander; P Nicotera; J Dypbukt; S Orrenius; A Hallberg
Increased activity of L-type Ca2+ channels exposed to serum from patients with type I diabetes.
Science (New York, N.Y.) 1993;261(5117):86-90.
1993: Olof Larsson; C Ammälä; Krister Bokvist; Bertil B. Fredholm; Patrik Rorsman
Stimulation of the KATP channel by ADP and diazoxide requires nucleotide hydrolysis in mouse pancreatic beta-cells.
The Journal of physiology 1993;463():349-65.
1992: Patrik Rorsman; C Ammälä; Per-Olof Berggren; Krister Bokvist; Olof Larsson
Cytoplasmic calcium transients due to single action potentials and voltage-clamp depolarizations in mouse pancreatic B-cells.
The EMBO journal 1992;11(8):2877-84.
1992: H Kindmark; M Köhler; S Efendić; Patrik Rorsman; Olof Larsson; Per-Olof Berggren
Protein kinase C activity affects glucose-induced oscillations in cytoplasmic free Ca2+ in the pancreatic B-cell.
FEBS letters 1992;303(1):85-90.
1992: M S Islam; Patrik Rorsman; Per-Olof Berggren
Ca(2+)-induced Ca2+ release in insulin-secreting cells.
FEBS letters 1992;296(3):287-91.
1992: C Ammälä; Per-Olof Berggren; Krister Bokvist; Patrik Rorsman
Inhibition of L-type calcium channels by internal GTP [gamma S] in mouse pancreatic beta cells.
Pflügers Archiv : European journal of physiology 1992;420(1):72-7.
1991: L Juntti-Berggren; P Arkhammar; T Nilsson; Patrik Rorsman; Per-Olof Berggren
Glucose-induced increase in cytoplasmic pH in pancreatic beta-cells is mediated by Na+/H+ exchange, an effect not dependent on protein kinase C.
The Journal of biological chemistry 1991;266(35):23537-41.
1991: C Ammälä; Olof Larsson; Per-Olof Berggren; Krister Bokvist; L Juntti-Berggren; H Kindmark; Patrik Rorsman
Inositol trisphosphate-dependent periodic activation of a Ca(2+)-activated K+ conductance in glucose-stimulated pancreatic beta-cells.
Nature 1991;353(6347):849-52.
1991: H Kindmark; M Köhler; T Nilsson; P Arkhammar; K L Wiechel; Patrik Rorsman; S Efendić; Per-Olof Berggren
Measurements of cytoplasmic free Ca2+ concentration in human pancreatic islets and insulinoma cells.
FEBS letters 1991;291(2):310-4.
1991: M S Islam; T Nilsson; Patrik Rorsman; Per-Olof Berggren
Interaction with the inositol 1,4,5-trisphosphate receptor promotes Ca2+ sequestration in permeabilised insulin-secreting cells.
FEBS letters 1991;288(1-2):27-9.
1991: Krister Bokvist; C Ammälä; Per-Olof Berggren; Patrik Rorsman; K Wåhlander
Alpha 2-adrenoreceptor stimulation does not inhibit L-type calcium channels in mouse pancreatic beta-cells.
Bioscience reports 1991;11(3):147-57.
1991: Krister Bokvist; C Ammälä; F M Ashcroft; Per-Olof Berggren; O Larsson; Patrik Rorsman
Separate processes mediate nucleotide-induced inhibition and stimulation of the ATP-regulated K(+)-channels in mouse pancreatic beta-cells.
Proceedings. Biological sciences / The Royal Society 1991;243(1307):139-44.
1991: Patrik Rorsman; Krister Bokvist; C Ammälä; P Arkhammar; Per-Olof Berggren; Olof Larsson; K Wåhlander
Activation by adrenaline of a low-conductance G protein-dependent K+ channel in mouse pancreatic B cells.
Nature 1991;349(6304):77-9.
1990: P A Smith; Krister Bokvist; P Arkhammar; Per-Olof Berggren; Patrik Rorsman
Delayed rectifying and calcium-activated K+ channels and their significance for action potential repolarization in mouse pancreatic beta-cells.
The Journal of general physiology 1990;95(6):1041-59.
1990: Krister Bokvist; Patrik Rorsman; P A Smith
Block of ATP-regulated and Ca2(+)-activated K+ channels in mouse pancreatic beta-cells by external tetraethylammonium and quinine.
The Journal of physiology 1990;423():327-42.
1990: Krister Bokvist; Patrik Rorsman; P A Smith
Effects of external tetraethylammonium ions and quinine on delayed rectifying K+ channels in mouse pancreatic beta-cells.
The Journal of physiology 1990;423():311-25.
1990: P Arkhammar; A Hallberg; H Kindmark; T Nilsson; Patrik Rorsman; Per-Olof Berggren
Extracellular ATP increases cytoplasmic free Ca2+ concentration in clonal insulin-producing RINm5F cells. A mechanism involving direct interaction with both release and refilling of the inositol 1,4,5-trisphosphate-sensitive Ca2+ pool.
The Biochemical journal 1990;265(1):203-11.
1989: P A Smith; Patrik Rorsman; F M Ashcroft
Modulation of dihydropyridine-sensitive Ca2+ channels by glucose metabolism in mouse pancreatic beta-cells.
Nature 1989;342(6249):550-3.
1989: Patrik Rorsman; Per-Olof Berggren; Krister Bokvist; H Ericson; H Möhler; C G Ostenson; P A Smith
Glucose-inhibition of glucagon secretion involves activation of GABAA-receptor chloride channels.
Nature 1989;341(6239):233-6.
1989: Patrik Rorsman; P Arkhammar; Krister Bokvist; C Hellerström; T Nilsson; M Welsh; Nils Welsh; Per-Olof Berggren
Failure of glucose to elicit a normal secretory response in fetal pancreatic beta cells results from glucose insensitivity of the ATP-regulated K+ channels.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(12):4505-9.
1989: T Nilsson; P Arkhammar; Patrik Rorsman; Per-Olof Berggren
Suppression of insulin release by galanin and somatostatin is mediated by a G-protein. An effect involving repolarization and reduction in cytoplasmic free Ca2+ concentration.
The Journal of biological chemistry 1989;264(2):973-80.
1988: F M Ashcroft; Stephen J H Ashcroft; Per-Olof Berggren; C Betzholz; Patrik Rorsman; G Trube; M Welsh
Expression of K channels in Xenopus laevis oocytes injected with poly(A+) mRNA from the insulin-secreting beta-cell line, HIT T15.
FEBS letters 1988;239(2):185-9.
1988: T Nilsson; P Arkhammar; Patrik Rorsman; Per-Olof Berggren
Inhibition of glucose-stimulated insulin release by alpha 2-adrenoceptor activation is parallelled by both a repolarization and a reduction in cytoplasmic free Ca2+ concentration.
The Journal of biological chemistry 1988;263(4):1855-60.
1988: Patrik Rorsman
Two types of Ca2+ currents with different sensitivities to organic Ca2+ channel antagonists in guinea pig pancreatic alpha 2 cells.
The Journal of general physiology 1988;91(2):243-54.
1988: Patrik Rorsman; B Hellman
Voltage-activated currents in guinea pig pancreatic alpha 2 cells. Evidence for Ca2+-dependent action potentials.
The Journal of general physiology 1988;91(2):223-42.
1987: N Wesslén; D Pipeleers; M Van de Winkel; Patrik Rorsman; Bo Hellman
Glucose stimulates the entry of Ca2+ into the insulin-producing beta cells but not into the glucagon-producing alpha 2 cells.
Acta physiologica Scandinavica 1987;131(2):230-4.