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Patrik Rorsman

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Anatomy

Physiology

Exocytosis

Living Beings

Chemicals & Drugs

Concepts & Ideas

Occupations

Electrophysiology

Procedures

Patch-Clamp Techniques

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Co-Publications
Name
37
Bokvist, Krister
34
Eliasson, Lena
33
Renström, Erik
27
Berggren, Per-Olof
27
Gromada, Jesper
22
Galvanovskis, Juris
20
Barg, Sebastian
17
Salehi, Albert
15
Ammälä, C
13
Göpel, Sven
11
MacDonald, Patrick
11
Braun, Matthias
10
Olofsson, Charlotta
10
Buschard, Karsten
8
Larsson, Olof

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Publications

TOP 3
Li Dai-Qing; Jing Xingjun; Salehi Albert; Collins Stephan C; Hoppa Michael B; Rosengren Anders H; Zhang Enming; Lundquist Ingmar; Olofsson Charlotta S; Mörgelin Matthias; Eliasson Lena; Rorsman Patrik; Renström Erik
Suppression of sulfonylurea- and glucose-induced insulin secretion in vitro and in vivo in mice lacking the chloride transport protein ClC-3.
Williams Siân E; Reed Anita A C; Galvanovskis Juris; Antignac Corinne; Goodship Tim; Karet Fiona E; Kotanko Peter; Lhotta Karl; Morinière Vincent; Williams Paul; Wong William; Rorsman Patrik; Thakker Rajesh V
Uromodulin mutations causing familial juvenile hyperuricaemic nephropathy lead to protein maturation defects and retention in the endoplasmic reticulum.
Braun M; Ramracheya R; Amisten S; Bengtsson M; Moritoh Y; Zhang Q; Johnson P R; Rorsman P
Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells.

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All Publications

2009: Li Dai-Qing; Jing Xingjun; Salehi Albert; Collins Stephan C; Hoppa Michael B; Rosengren Anders H; Zhang Enming; Lundquist Ingmar; Olofsson Charlotta S; Mörgelin Matthias; Eliasson Lena; Rorsman Patrik; Renström Erik
Suppression of sulfonylurea- and glucose-induced insulin secretion in vitro and in vivo in mice lacking the chloride transport protein ClC-3.
Cell metabolism 2009;10(4):309-15.
2009: Williams Siân E; Reed Anita A C; Galvanovskis Juris; Antignac Corinne; Goodship Tim; Karet Fiona E; Kotanko Peter; Lhotta Karl; Morinière Vincent; Williams Paul; Wong William; Rorsman Patrik; Thakker Rajesh V
Uromodulin mutations causing familial juvenile hyperuricaemic nephropathy lead to protein maturation defects and retention in the endoplasmic reticulum.
Human molecular genetics 2009;18(16):2963-74.
2009: Braun M; Ramracheya R; Amisten S; Bengtsson M; Moritoh Y; Zhang Q; Johnson P R; Rorsman P
Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells.
Diabetologia 2009;52(8):1566-78.
2009: Olofsson Charlotta S; Håkansson Joakim; Salehi Albert; Bengtsson Martin; Galvanovskis Juris; Partridge Chris; SörhedeWinzell Maria; Xian Xiaojie; Eliasson Lena; Lundquist Ingmar; Semb Henrik; Rorsman Patrik
Impaired insulin exocytosis in neural cell adhesion molecule-/- mice due to defective reorganization of the submembrane F-actin network.
Endocrinology 2009;150(7):3067-75.
2009: Karanauskaite Jovita; Hoppa Michael B; Braun Matthias; Galvanovskis Juris; Rorsman Patrik
Quantal ATP release in rat beta-cells by exocytosis of insulin-containing LDCVs.
Pflügers Archiv : European journal of physiology 2009;458(2):389-401.
2009: Poy Matthew N; Hausser Jean; Trajkovski Mirko; Braun Matthias; Collins Stephan; Rorsman Patrik; Zavolan Mihaela; Stoffel Markus
miR-375 maintains normal pancreatic alpha- and beta-cell mass.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(14):5813-8.
2009: Hanna Salma T; Pigeau Gary M; Galvanovskis Juris; Clark Anne; Rorsman Patrik; MacDonald Patrick E
Kiss-and-run exocytosis and fusion pores of secretory vesicles in human beta-cells.
Pflügers Archiv : European journal of physiology 2009;457(6):1343-50.
2009: Mårtensson Ulrika E A; Salehi S Albert; Windahl Sara; Gomez Maria F; Swärd Karl; Daszkiewicz-Nilsson Joanna; Wendt Anna; Andersson Niklas; Hellstrand Per; Grände Per-Olof; Owman Christer; Rosen Clifford J; Adamo Martin L; Lundquist Ingmar; Rorsman Patrik; Nilsson Bengt-Olof; Ohlsson Claes; Olde Björn; Leeb-Lundberg L M Fredrik
Deletion of the G protein-coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol-stimulated insulin release in female mice.
Endocrinology 2009;150(2):687-98.
2009: Braun Matthias; Ramracheya Reshma; Johnson Paul R; Rorsman Patrik
Exocytotic properties of human pancreatic beta-cells.
Annals of the New York Academy of Sciences 2009;1152():187-93.
2009: Sumara Grzegorz; Formentini Ivan; Collins Stephan; Sumara Izabela; Windak Renata; Bodenmiller Bernd; Ramracheya Reshma; Caille Dorothée; Jiang Huiping; Platt Kenneth A; Meda Paolo; Aebersold Rudolf; Rorsman Patrik; Ricci Romeo
Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis.
Cell 2009;136(2):235-48.
2009: Girard Christophe A; Wunderlich F Thomas; Shimomura Kenju; Collins Stephan; Kaizik Stephan; Proks Peter; Abdulkader Fernando; Clark Anne; Ball Vicky; Zubcevic Lejla; Bentley Liz; Clark Rebecca; Church Chris; Hugill Alison; Galvanovskis Juris; Cox Roger; Rorsman Patrik; Brüning Jens C; Ashcroft Frances M
Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes.
The Journal of clinical investigation 2009;119(1):80-90.
2008: Zehetner Jens; Danzer Carsten; Collins Stephan; Eckhardt Katrin; Gerber Philipp A; Ballschmieter Pia; Galvanovskis Juris; Shimomura Kenju; Ashcroft Frances M; Thorens Bernard; Rorsman Patrik; Krek Wilhelm
PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells.
Genes & development 2008;22(22):3135-46.
2008: Rorsman Patrik; Salehi S Albert; Abdulkader Fernando; Braun Matthias; MacDonald Patrick E
K(ATP)-channels and glucose-regulated glucagon secretion.
Trends in endocrinology and metabolism: TEM 2008;19(8):277-84.
2008: Zhang Quan; Galvanovskis Juris; Abdulkader Fernando; Partridge Christopher J; Göpel Sven O; Eliasson Lena; Rorsman Patrik
Cell coupling in mouse pancreatic beta-cells measured in intact islets of Langerhans.
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences 2008;366(1880):3503-23.
2008: Collins S C; Salehi A; Eliasson L; Olofsson C S; Rorsman P
Long-term exposure of mouse pancreatic islets to oleate or palmitate results in reduced glucose-induced somatostatin and oversecretion of glucagon.
Diabetologia 2008;51(9):1689-93.
2008: Eliasson Lena; Abdulkader Fernando; Braun Matthias; Galvanovskis Juris; Hoppa Michael B; Rorsman Patrik
Novel aspects of the molecular mechanisms controlling insulin secretion.
The Journal of physiology 2008;586(14):3313-24.
2008: Braun Matthias; Ramracheya Reshma; Bengtsson Martin; Zhang Quan; Karanauskaite Jovita; Partridge Chris; Johnson Paul R; Rorsman Patrik
Voltage-gated ion channels in human pancreatic beta-cells: electrophysiological characterization and role in insulin secretion.
Diabetes 2008;57(6):1618-28.
2008: Speidel Dina; Salehi Albert; Obermueller Stefanie; Lundquist Ingmar; Brose Nils; Renström Erik; Rorsman Patrik
CAPS1 and CAPS2 regulate stability and recruitment of insulin granules in mouse pancreatic beta cells.
Cell metabolism 2008;7(1):57-67.
2008: Wallis Robert H; Collins Stephan C; Kaisaki Pamela J; Argoud Karène; Wilder Steven P; Wallace Karin J; Ria Massimiliano; Ktorza Alain; Rorsman Patrik; Bihoreau Marie-Thérèse; Gauguier Dominique
Pathophysiological, genetic and gene expression features of a novel rodent model of the cardio-metabolic syndrome.
PloS one 2008;3(8):e2962.
2008: Bengtsson Martin; Hemberg Martin; Rorsman Patrik; Ståhlberg Anders
Quantification of mRNA in single cells and modelling of RT-qPCR induced noise.
BMC molecular biology 2008;9():63.
2007: Gerken Thomas; Girard Christophe A; Tung Yi-Chun Loraine; Webby Celia J; Saudek Vladimir; Hewitson Kirsty S; Yeo Giles S H; McDonough Michael A; Cunliffe Sharon; McNeill Luke A; Galvanovskis Juris; Rorsman Patrik; Robins Peter; Prieur Xavier; Coll Anthony P; Ma Marcella; Jovanovic Zorica; Farooqi I Sadaf; Sedgwick Barbara; Barroso Inês; Lindahl Tomas; Ponting Chris P; Ashcroft Frances M; O'Rahilly Stephen; Schofield Christopher J
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.
Science (New York, N.Y.) 2007;318(5855):1469-72.
2007: Olofsson Charlotta S; Collins Stephan; Bengtsson Martin; Eliasson Lena; Salehi Albert; Shimomura Kenju; Tarasov Andrei; Holm Cecilia; Ashcroft Frances; Rorsman Patrik
Long-term exposure to glucose and lipids inhibits glucose-induced insulin secretion downstream of granule fusion with plasma membrane.
Diabetes 2007;56(7):1888-97.
2007: MacDonald Patrick E; De Marinis Yang Zhang; Ramracheya Reshma; Salehi Albert; Ma Xiaosong; Johnson Paul R V; Cox Roger; Eliasson Lena; Rorsman Patrik
A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans.
PLoS biology 2007;5(6):e143.
2007: MacDonald Patrick E; Rorsman Patrik
The ins and outs of secretion from pancreatic beta-cells: control of single-vesicle exo- and endocytosis.
Physiology (Bethesda, Md.) 2007;22():113-21.
2007: Zhang Quan; Bengtsson Martin; Partridge Chris; Salehi Albert; Braun Matthias; Cox Roger; Eliasson Lena; Johnson Paul R V; Renström Erik; Schneider Toni; Berggren Per-Olof; Göpel Sven; Ashcroft Frances M; Rorsman Patrik
R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion.
Nature cell biology 2007;9(4):453-60.
2007: Braun Matthias; Wendt Anna; Karanauskaite Jovita; Galvanovskis Juris; Clark Anne; MacDonald Patrick E; Rorsman Patrik
Corelease and differential exit via the fusion pore of GABA, serotonin, and ATP from LDCV in rat pancreatic beta cells.
The Journal of general physiology 2007;129(3):221-31.
2007: Jeans Alexander F; Oliver Peter L; Johnson Reuben; Capogna Marco; Vikman Jenny; Molnár Zoltán; Babbs Arran; Partridge Christopher J; Salehi Albert; Bengtsson Martin; Eliasson Lena; Rorsman Patrik; Davies Kay E
A dominant mutation in Snap25 causes impaired vesicle trafficking, sensorimotor gating, and ataxia in the blind-drunk mouse.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(7):2431-6.
2006: MacDonald Patrick E; Braun Matthias; Galvanovskis Juris; Rorsman Patrik
Release of small transmitters through kiss-and-run fusion pores in rat pancreatic beta cells.
Cell metabolism 2006;4(4):283-90.
2006: Vikman Jenny; Ma Xiaosong; Hockerman Gregory H; Rorsman Patrik; Eliasson Lena
Antibody inhibition of synaptosomal protein of 25 kDa (SNAP-25) and syntaxin 1 reduces rapid exocytosis in insulin-secreting cells.
Journal of molecular endocrinology 2006;36(3):503-15.
2006: MacDonald Patrick E; Rorsman Patrik
Oscillations, intercellular coupling, and insulin secretion in pancreatic beta cells.
PLoS biology 2006;4(2):e49.
2005: MacDonald Patrick E; Joseph Jamie W; Rorsman Patrik
Glucose-sensing mechanisms in pancreatic beta-cells.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2005;360(1464):2211-25.
2005: MacDonald Patrick E; Eliasson Lena; Rorsman Patrik
Calcium increases endocytotic vesicle size and accelerates membrane fission in insulin-secreting INS-1 cells.
Journal of cell science 2005;118(Pt 24):5911-20.
2005: Obermüller Stefanie; Lindqvist Anders; Karanauskaite Jovita; Galvanovskis Juris; Rorsman Patrik; Barg Sebastian
Selective nucleotide-release from dense-core granules in insulin-secreting cells.
Journal of cell science 2005;118(Pt 18):4271-82.
2005: MacDonald Patrick E; Obermüller Stefanie; Vikman Jenny; Galvanovskis Juris; Rorsman Patrik; Eliasson Lena
Regulated exocytosis and kiss-and-run of synaptic-like microvesicles in INS-1 and primary rat beta-cells.
Diabetes 2005;54(3):736-43.
2005: Jing Xingjun; Li Dai-Qing; Olofsson Charlotta S; Salehi Albert; Surve Vikas V; Caballero José; Ivarsson Rosita; Lundquist Ingmar; Pereverzev Alexey; Schneider Toni; Rorsman Patrik; Renström Erik
CaV2.3 calcium channels control second-phase insulin release.
The Journal of clinical investigation 2005;115(1):146-54.
2005: Ma Xiaosong; Zhang Yang; Gromada Jesper; Sewing Sabine; Berggren Per-Olof; Buschard Karsten; Salehi Albert; Vikman Jenny; Rorsman Patrik; Eliasson Lena
Glucagon stimulates exocytosis in mouse and rat pancreatic alpha-cells by binding to glucagon receptors.
Molecular endocrinology (Baltimore, Md.) 2005;19(1):198-212.
2004: Barg Sebastian; Rorsman Patrik
Insulin secretion: a high-affinity Ca2+ sensor after all?
The Journal of general physiology 2004;124(6):623-5.
2004: Gromada Jesper; Ma Xiaosong; Høy Marianne; Bokvist Krister; Salehi Albert; Berggren Per-Olof; Rorsman Patrik
ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical activity by glucose in wild-type and SUR1-/- mouse alpha-cells.
Diabetes 2004;53 Suppl 3():S181-9.
2004: Poy Matthew N; Eliasson Lena; Krutzfeldt Jan; Kuwajima Satoru; Ma Xiaosong; Macdonald Patrick E; Pfeffer Sébastien; Tuschl Thomas; Rajewsky Nikolaus; Rorsman Patrik; Stoffel Markus
A pancreatic islet-specific microRNA regulates insulin secretion.
Nature 2004;432(7014):226-30.
2004: Olofsson Charlotta S; Salehi Albert; Göpel Sven O; Holm Cecilia; Rorsman Patrik
Palmitate stimulation of glucagon secretion in mouse pancreatic alpha-cells results from activation of L-type calcium channels and elevation of cytoplasmic calcium.
Diabetes 2004;53(11):2836-43.
2004: Braun Matthias; Wendt Anna; Buschard Karsten; Salehi Albert; Sewing Sabine; Gromada Jesper; Rorsman Patrik
GABAB receptor activation inhibits exocytosis in rat pancreatic beta-cells by G-protein-dependent activation of calcineurin.
The Journal of physiology 2004;559(Pt 2):397-409.
2004: Kanno Takahiro; Ma Xiasong; Barg Sebastian; Eliasson Lena; Galvanovskis Juris; Göpel Sven; Larsson Max; Renström Erik; Rorsman Patrik
Large dense-core vesicle exocytosis in pancreatic beta-cells monitored by capacitance measurements.
Methods (San Diego, Calif.) 2004;33(4):302-11.
2004: Fex Malin; Olofsson Charlotta S; Fransson Ulrika; Bacos Karl; Lindvall Håkan; Sörhede-Winzell Maria; Rorsman Patrik; Holm Cecilia; Mulder Hindrik
Hormone-sensitive lipase deficiency in mouse islets abolishes neutral cholesterol ester hydrolase activity but leaves lipolysis, acylglycerides, fat oxidation, and insulin secretion intact.
Endocrinology 2004;145(8):3746-53.
2004: Hansson Karin; Ma Xiaosong; Eliasson Lena; Czerwiec Eva; Furie Bruce; Furie Barbara C; Rorsman Patrik; Stenflo Johan
The first gamma-carboxyglutamic acid-containing contryphan. A selective L-type calcium ion channel blocker isolated from the venom of Conus marmoreus.
The Journal of biological chemistry 2004;279(31):32453-63.
2004: Olofsson Charlotta S; Salehi Albert; Holm Cecilia; Rorsman Patrik
Palmitate increases L-type Ca2+ currents and the size of the readily releasable granule pool in mouse pancreatic beta-cells.
The Journal of physiology 2004;557(Pt 3):935-48.
2004: Sinnegger-Brauns Martina J; Hetzenauer Alfred; Huber Irene G; Renström Erik; Wietzorrek Georg; Berjukov Stanislav; Cavalli Maurizio; Walter Doris; Koschak Alexandra; Waldschütz Ralph; Hering Steffen; Bova Sergio; Rorsman Patrik; Pongs Olaf; Singewald Nicolas; Striessnig J J öRg
Isoform-specific regulation of mood behavior and pancreatic beta cell and cardiovascular function by L-type Ca 2+ channels.
The Journal of clinical investigation 2004;113(10):1430-9.
2004: Ashcroft Frances M; Rorsman Patrik
Molecular defects in insulin secretion in type-2 diabetes.
Reviews in endocrine & metabolic disorders 2004;5(2):135-42.
2004: Göpel Sven; Zhang Quan; Eliasson Lena; Ma Xiao-Song; Galvanovskis Juris; Kanno Takahiro; Salehi Albert; Rorsman Patrik
Capacitance measurements of exocytosis in mouse pancreatic alpha-, beta- and delta-cells within intact islets of Langerhans.
The Journal of physiology 2004;556(Pt 3):711-26.
2004: Wendt Anna; Birnir Bryndis; Buschard Karsten; Gromada Jesper; Salehi Albert; Sewing Sabine; Rorsman Patrik; Braun Matthias
Glucose inhibition of glucagon secretion from rat alpha-cells is mediated by GABA released from neighboring beta-cells.
Diabetes 2004;53(4):1038-45.
2004: Ashcroft Frances; Rorsman Patrik
Type 2 diabetes mellitus: not quite exciting enough?
Human molecular genetics 2004;13 Spec No 1():R21-31.
2004: Braun Matthias; Wendt Anna; Birnir Bryndis; Broman Jonas; Eliasson Lena; Galvanovskis Juris; Gromada Jesper; Mulder Hindrik; Rorsman Patrik
Regulated exocytosis of GABA-containing synaptic-like microvesicles in pancreatic beta-cells.
The Journal of general physiology 2004;123(3):191-204.
2003: Schulla Verena; Renström Erik; Feil Robert; Feil Susanne; Franklin Isobel; Gjinovci Asllan; Jing Xing-Jun; Laux Dirk; Lundquist Ingmar; Magnuson Mark A; Obermüller Stefanie; Olofsson Charlotta S; Salehi Albert; Wendt Anna; Klugbauer Norbert; Wollheim Claes B; Rorsman Patrik; Hofmann Franz
Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice.
The EMBO journal 2003;22(15):3844-54.
2003: Rorsman P; Renström E
Insulin granule dynamics in pancreatic beta cells.
Diabetologia 2003;46(8):1029-45.
2003: Olsen Hervør L; Hoy Marianne; Zhang Wei; Bertorello Alejandro M; Bokvist Krister; Capito Kirsten; Efanov Alexander M; Meister Björn; Thams Peter; Yang Shao-Nian; Rorsman Patrik; Berggren Per-Olof; Gromada Jesper
Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic beta cells.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(9):5187-92.
2003: Høy Marianne; Olsen Hervør L; Andersen Henrik S; Bokvist Krister; Buschard Karsten; Hansen John; Jacobsen Palle; Petersen Jacob S; Rorsman Patrik; Gromada Jesper
Imidazoline NNC77-0074 stimulates insulin secretion and inhibits glucagon release by control of Ca(2+)-dependent exocytosis in pancreatic alpha- and beta-cells.
European journal of pharmacology 2003;466(1-2):213-21.
2003: Eliasson Lena; Ma Xiaosong; Renström Erik; Barg Sebastian; Berggren Per-Olof; Galvanovskis Juris; Gromada Jesper; Jing Xingjun; Lundquist Ingmar; Salehi Albert; Sewing Sabine; Rorsman Patrik
SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells.
The Journal of general physiology 2003;121(3):181-97.
2002: Kanno T; Rorsman P; Göpel S O
Glucose-dependent regulation of rhythmic action potential firing in pancreatic beta-cells by K(ATP)-channel modulation.
The Journal of physiology 2002;545(Pt 2):501-7.
2002: Gromada Jesper; Bokvist Krister; Høy Marianne; Olsen Hervør L; Lindström Per; Hansen Birgit S; Gotfredsen Carsten F; Rorsman Patrik; Thomsen Mads Krogsgaard
Nateglinide, but not repaglinide, stimulates growth hormone release in rat pituitary cells by inhibition of K channels and stimulation of cyclic AMP-dependent exocytosis.
European journal of endocrinology / European Federation of Endocrine Societies 2002;147(1):133-42.
2002: Olofsson Charlotta S; Göpel Sven O; Barg Sebastian; Galvanovskis Juris; Ma Xiaosong; Salehi Albert; Rorsman Patrik; Eliasson Lena
Fast insulin secretion reflects exocytosis of docked granules in mouse pancreatic B-cells.
Pflügers Archiv : European journal of physiology 2002;444(1-2):43-51.
2002: Kanno Takahiro; Gopel Sven O; Rorsman Patrik; Wakui Makoto
Cellular function in multicellular system for hormone-secretion: electrophysiological aspect of studies on alpha-, beta- and delta-cells of the pancreatic islet.
Neuroscience research 2002;42(2):79-90.
2002: Barg Sebastian; Eliasson Lena; Renström Erik; Rorsman Patrik
A subset of 50 secretory granules in close contact with L-type Ca2+ channels accounts for first-phase insulin secretion in mouse beta-cells.
Diabetes 2002;51 Suppl 1():S74-82.
2002: Renström Erik; Barg Sebastian; Thévenod Frank; Rorsman Patrik
Sulfonylurea-mediated stimulation of insulin exocytosis via an ATP-sensitive K+ channel-independent action.
Diabetes 2002;51 Suppl 1():S33-6.
2002: Barg Sebastian; Olofsson Charlotta S; Schriever-Abeln Jenny; Wendt Anna; Gebre-Medhin Samuel; Renström Erik; Rorsman Patrik
Delay between fusion pore opening and peptide release from large dense-core vesicles in neuroendocrine cells.
Neuron 2002;33(2):287-99.
2001: Barg S; Ma X; Eliasson L; Galvanovskis J; Göpel S O; Obermüller S; Platzer J; Renström E; Trus M; Atlas D; Striessnig J; Rorsman P
Fast exocytosis with few Ca(2+) channels in insulin-secreting mouse pancreatic B cells.
Biophysical journal 2001;81(6):3308-23.
2001: Gromada J; Høy M; Buschard K; Salehi A; Rorsman P
Somatostatin inhibits exocytosis in rat pancreatic alpha-cells by G(i2)-dependent activation of calcineurin and depriming of secretory granules.
The Journal of physiology 2001;535(Pt 2):519-32.
2001: Barg S; Huang P; Eliasson L; Nelson D J; Obermüller S; Rorsman P; Thévenod F; Renström E
Priming of insulin granules for exocytosis by granular Cl(-) uptake and acidification.
Journal of cell science 2001;114(Pt 11):2145-54.
2001: Gromada J; Høy M; Olsen H L; Gotfredsen C F; Buschard K; Rorsman P; Bokvist K
Gi2 proteins couple somatostatin receptors to low-conductance K+ channels in rat pancreatic alpha-cells.
Pflügers Archiv : European journal of physiology 2001;442(1):19-26.
2001: Larsson-Nyrén G; Sehlin J; Rorsman P; Renström E
Perchlorate stimulates insulin secretion by shifting the gating of L-type Ca2+ currents in mouse pancreatic B-cells towards negative potentials.
Pflügers Archiv : European journal of physiology 2001;441(5):587-95.
2000: Göpel S O; Kanno T; Barg S; Weng X G; Gromada J; Rorsman P
Regulation of glucagon release in mouse -cells by KATP channels and inactivation of TTX-sensitive Na+ channels.
The Journal of physiology 2000;528(Pt 3):509-20.
2000: Göpel S O; Kanno T; Barg S; Rorsman P
Patch-clamp characterisation of somatostatin-secreting -cells in intact mouse pancreatic islets.
The Journal of physiology 2000;528(Pt 3):497-507.
2000: Barg S; Galvanovskis J; Göpel S O; Rorsman P; Eliasson L
Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting alpha-cells.
Diabetes 2000;49(9):1500-10.
2000: Høy M; Olsen H L; Bokvist K; Buschard K; Barg S; Rorsman P; Gromada J
Tolbutamide stimulates exocytosis of glucagon by inhibition of a mitochondrial-like ATP-sensitive K+ (KATP) conductance in rat pancreatic A-cells.
The Journal of physiology 2000;527 Pt 1():109-20.
2000: Bokvist K; Holmqvist M; Gromada J; Rorsman P
Compound exocytosis in voltage-clamped mouse pancreatic beta-cells revealed by carbon fibre amperometry.
Pflügers Archiv : European journal of physiology 2000;439(5):634-45.
1999: Rorsman P; Renström E
Cell biology. Glutamate primes the pump.
Nature 1999;402(6762):595-6.
1999: Göpel S; Kanno T; Barg S; Galvanovskis J; Rorsman P
Voltage-gated and resting membrane currents recorded from B-cells in intact mouse pancreatic islets.
The Journal of physiology 1999;521 Pt 3():717-28.
1999: Göpel S O; Kanno T; Barg S; Eliasson L; Galvanovskis J; Renström E; Rorsman P
Activation of Ca(2+)-dependent K(+) channels contributes to rhythmic firing of action potentials in mouse pancreatic beta cells.
The Journal of general physiology 1999;114(6):759-70.
1999: Bokvist K; Olsen H L; Høy M; Gotfredsen C F; Holmes W F; Buschard K; Rorsman P; Gromada J
Characterisation of sulphonylurea and ATP-regulated K+ channels in rat pancreatic A-cells.
Pflügers Archiv : European journal of physiology 1999;438(4):428-36.
1999: Gromada J; Høy M; Renström E; Bokvist K; Eliasson L; Göpel S; Rorsman P
CaM kinase II-dependent mobilization of secretory granules underlies acetylcholine-induced stimulation of exocytosis in mouse pancreatic B-cells.
The Journal of physiology 1999;518 ( Pt 3)():745-59.
1999: Barg S; Renström E; Berggren P O; Bertorello A; Bokvist K; Braun M; Eliasson L; Holmes W E; Köhler M; Rorsman P; Thévenod F
The stimulatory action of tolbutamide on Ca2+-dependent exocytosis in pancreatic beta cells is mediated by a 65-kDa mdr-like P-glycoprotein.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(10):5539-44.
1999: Gall D; Gromada J; Susa I; Rorsman P; Herchuelz A; Bokvist K
Significance of Na/Ca exchange for Ca2+ buffering and electrical activity in mouse pancreatic beta-cells.
Biophysical journal 1999;76(4):2018-28.
1999: Mulder H; Holst L S; Svensson H; Degerman E; Sundler F; Ahrén B; Rorsman P; Holm C
Hormone-sensitive lipase, the rate-limiting enzyme in triglyceride hydrolysis, is expressed and active in beta-cells.
Diabetes 1999;48(1):228-32.
1999: Wiser O; Trus M; Hernández A; Renström E; Barg S; Rorsman P; Atlas D
The voltage sensitive Lc-type Ca2+ channel is functionally coupled to the exocytotic machinery.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(1):248-53.
1998: Gromada J; Holst J J; Rorsman P
Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1.
Pflügers Archiv : European journal of physiology 1998;435(5):583-94.
1998: Gromada J; Bokvist K; Ding W G; Holst J J; Nielsen J H; Rorsman P
Glucagon-like peptide 1 (7-36) amide stimulates exocytosis in human pancreatic beta-cells by both proximal and distal regulatory steps in stimulus-secretion coupling.
Diabetes 1998;47(1):57-65.
1997: Eliasson L; Renström E; Ding W G; Proks P; Rorsman P
Rapid ATP-dependent priming of secretory granules precedes Ca(2+)-induced exocytosis in mouse pancreatic B-cells.
The Journal of physiology 1997;503 ( Pt 2)():399-412.
1997: Gromada J; Bokvist K; Ding W G; Barg S; Buschard K; Renström E; Rorsman P
Adrenaline stimulates glucagon secretion in pancreatic A-cells by increasing the Ca2+ current and the number of granules close to the L-type Ca2+ channels.
The Journal of general physiology 1997;110(3):217-28.
1997: Gromada J; Ding W G; Barg S; Renström E; Rorsman P
Multisite regulation of insulin secretion by cAMP-increasing agonists: evidence that glucagon-like peptide 1 and glucagon act via distinct receptors.
Pflügers Archiv : European journal of physiology 1997;434(5):515-24.
1997: Renström E; Eliasson L; Rorsman P
Protein kinase A-dependent and -independent stimulation of exocytosis by cAMP in mouse pancreatic B-cells.
The Journal of physiology 1997;502 ( Pt 1)():105-18.
1997: Rorsman P
The pancreatic beta-cell as a fuel sensor: an electrophysiologist's viewpoint.
Diabetologia 1997;40(5):487-95.
1997: Ding W G; Renström E; Rorsman P; Buschard K; Gromada J
Glucagon-like peptide I and glucose-dependent insulinotropic polypeptide stimulate Ca2+-induced secretion in rat alpha-cells by a protein kinase A-mediated mechanism.
Diabetes 1997;46(5):792-800.
1997: Rorsman P; Eliasson L; Renström E
Components of insulin secretion: lessons to be learnt from capacitance.
The Japanese journal of physiology 1997;47 Suppl 1():S21.
1996: Proks P; Eliasson L; Ammälä C; Rorsman P; Ashcroft F M
Ca(2+)- and GTP-dependent exocytosis in mouse pancreatic beta-cells involves both common and distinct steps.
The Journal of physiology 1996;496 ( Pt 1)():255-64.
1996: Renström E; Ding W G; Bokvist K; Rorsman P
Neurotransmitter-induced inhibition of exocytosis in insulin-secreting beta cells by activation of calcineurin.
Neuron 1996;17(3):513-22.
1996: Gromada J; Rorsman P
Molecular mechanism underlying glucagon-like peptide 1 induced calcium mobilization from internal stores in insulin-secreting beta TC3 cells.
Acta physiologica Scandinavica 1996;157(3):349-51.
1996: Renström E; Eliasson L; Bokvist K; Rorsman P
Cooling inhibits exocytosis in single mouse pancreatic B-cells by suppression of granule mobilization.
The Journal of physiology 1996;494 ( Pt 1)():41-52.
1996: Eliasson L; Proks P; Ammälä C; Ashcroft F M; Bokvist K; Renström E; Rorsman P; Smith P A
Endocytosis of secretory granules in mouse pancreatic beta-cells evoked by transient elevation of cytosolic calcium.
The Journal of physiology 1996;493 ( Pt 3)():755-67.
1996: Gromada J; Dissing S; Rorsman P
Desensitization of glucagon-like peptide 1 receptors in insulin-secreting beta TC3 cells: role of PKA-independent mechanisms.
British journal of pharmacology 1996;118(3):769-75.
1996: Malaisse W J; Lebrun P; Pirotte B; Van Poelje P D; Viñambres C; Villanueva-Peñacarrillo M L; Valverde I; Gäbel J; Rorsman P
The riddle of formycin A insulinotropic action.
Biochemical and molecular medicine 1996;57(1):47-63.
1996: Eliasson L; Renström E; Ammälä C; Berggren P O; Bertorello A M; Bokvist K; Chibalin A; Deeney J T; Flatt P R; Gäbel J; Gromada J; Larsson O; Lindström P; Rhodes C J; Rorsman P
PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic beta cells.
Science (New York, N.Y.) 1996;271(5250):813-5.
1996: Lebrun P; Renström E; Antoine M H; Bokvist K; Holmquist M; Rorsman P; Malaisse W J
Dynamics of the cationic, bioelectrical and secretory responses to formycin A in pancreatic islet cells.
Pflügers Archiv : European journal of physiology 1996;431(3):353-62.
1995: Gromada J; Rorsman P; Dissing S; Wulff B S
Stimulation of cloned human glucagon-like peptide 1 receptor expressed in HEK 293 cells induces cAMP-dependent activation of calcium-induced calcium release.
FEBS letters 1995;373(2):182-6.
1995: Gromada J; Dissing S; Bokvist K; Renström E; Frøkjaer-Jensen J; Wulff B S; Rorsman P
Glucagon-like peptide I increases cytoplasmic calcium in insulin-secreting beta TC3-cells by enhancement of intracellular calcium mobilization.
Diabetes 1995;44(7):767-74.
1995: Bokvist K; Eliasson L; Ammälä C; Renström E; Rorsman P
Co-localization of L-type Ca2+ channels and insulin-containing secretory granules and its significance for the initiation of exocytosis in mouse pancreatic B-cells.
The EMBO journal 1995;14(1):50-7.
1994: Ammälä C; Eliasson L; Bokvist K; Berggren P O; Honkanen R E; Sjöholm A; Rorsman P
Activation of protein kinases and inhibition of protein phosphatases play a central role in the regulation of exocytosis in mouse pancreatic beta cells.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(10):4343-7.
1994: Ashcroft F M; Proks P; Smith P A; Ammälä C; Bokvist K; Rorsman P
Stimulus-secretion coupling in pancreatic beta cells.
Journal of cellular biochemistry 1994;55 Suppl():54-65.
1993: Ammälä C; Eliasson L; Bokvist K; Larsson O; Ashcroft F M; Rorsman P
Exocytosis elicited by action potentials and voltage-clamp calcium currents in individual mouse pancreatic B-cells.
The Journal of physiology 1993;472():665-88.
1993: Sjöholm A; Arkhammar P; Welsh N; Bokvist K; Rorsman P; Hallberg A; Nilsson T; Welsh M; Berggren P O
Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity.
The Journal of clinical investigation 1993;92(4):1910-7.
1993: Juntti-Berggren L; Larsson O; Rorsman P; Ammälä C; Bokvist K; Wåhlander K; Nicotera P; Dypbukt J; Orrenius S; Hallberg A
Increased activity of L-type Ca2+ channels exposed to serum from patients with type I diabetes.
Science (New York, N.Y.) 1993;261(5117):86-90.
1993: Larsson O; Ammälä C; Bokvist K; Fredholm B; Rorsman P
Stimulation of the KATP channel by ADP and diazoxide requires nucleotide hydrolysis in mouse pancreatic beta-cells.
The Journal of physiology 1993;463():349-65.
1992: Rorsman P; Ammälä C; Berggren P O; Bokvist K; Larsson O
Cytoplasmic calcium transients due to single action potentials and voltage-clamp depolarizations in mouse pancreatic B-cells.
The EMBO journal 1992;11(8):2877-84.
1992: Kindmark H; Köhler M; Efendic S; Rorsman P; Larsson O; Berggren P O
Protein kinase C activity affects glucose-induced oscillations in cytoplasmic free Ca2+ in the pancreatic B-cell.
FEBS letters 1992;303(1):85-90.
1992: Islam M S; Rorsman P; Berggren P O
Ca(2+)-induced Ca2+ release in insulin-secreting cells.
FEBS letters 1992;296(3):287-91.
1992: Ammälä C; Berggren P O; Bokvist K; Rorsman P
Inhibition of L-type calcium channels by internal GTP [gamma S] in mouse pancreatic beta cells.
Pflügers Archiv : European journal of physiology 1992;420(1):72-7.
1991: Juntti-Berggren L; Arkhammar P; Nilsson T; Rorsman P; Berggren P O
Glucose-induced increase in cytoplasmic pH in pancreatic beta-cells is mediated by Na+/H+ exchange, an effect not dependent on protein kinase C.
The Journal of biological chemistry 1991;266(35):23537-41.
1991: Kindmark H; Köhler M; Nilsson T; Arkhammar P; Wiechel K L; Rorsman P; Efendic S; Berggren P O
Measurements of cytoplasmic free Ca2+ concentration in human pancreatic islets and insulinoma cells.
FEBS letters 1991;291(2):310-4.
1991: Ammälä C; Larsson O; Berggren P O; Bokvist K; Juntti-Berggren L; Kindmark H; Rorsman P
Inositol trisphosphate-dependent periodic activation of a Ca(2+)-activated K+ conductance in glucose-stimulated pancreatic beta-cells.
Nature 1991;353(6347):849-52.
1991: Islam M S; Nilsson T; Rorsman P; Berggren P O
Interaction with the inositol 1,4,5-trisphosphate receptor promotes Ca2+ sequestration in permeabilised insulin-secreting cells.
FEBS letters 1991;288(1-2):27-9.
1991: Bokvist K; Ammälä C; Berggren P O; Rorsman P; Wåhlander K
Alpha 2-adrenoreceptor stimulation does not inhibit L-type calcium channels in mouse pancreatic beta-cells.
Bioscience reports 1991;11(3):147-57.
1991: Bokvist K; Ammälä C; Ashcroft F M; Berggren P O; Larsson O; Rorsman P
Separate processes mediate nucleotide-induced inhibition and stimulation of the ATP-regulated K(+)-channels in mouse pancreatic beta-cells.
Proceedings. Biological sciences / The Royal Society 1991;243(1307):139-44.
1991: Rorsman P; Bokvist K; Ammälä C; Arkhammar P; Berggren P O; Larsson O; Wåhlander K
Activation by adrenaline of a low-conductance G protein-dependent K+ channel in mouse pancreatic B cells.
Nature 1991;349(6304):77-9.
1990: Smith P A; Bokvist K; Arkhammar P; Berggren P O; Rorsman P
Delayed rectifying and calcium-activated K+ channels and their significance for action potential repolarization in mouse pancreatic beta-cells.
The Journal of general physiology 1990;95(6):1041-59.
1990: Bokvist K; Rorsman P; Smith P A
Block of ATP-regulated and Ca2(+)-activated K+ channels in mouse pancreatic beta-cells by external tetraethylammonium and quinine.
The Journal of physiology 1990;423():327-42.
1990: Bokvist K; Rorsman P; Smith P A
Effects of external tetraethylammonium ions and quinine on delayed rectifying K+ channels in mouse pancreatic beta-cells.
The Journal of physiology 1990;423():311-25.
1990: Arkhammar P; Hallberg A; Kindmark H; Nilsson T; Rorsman P; Berggren P O
Extracellular ATP increases cytoplasmic free Ca2+ concentration in clonal insulin-producing RINm5F cells. A mechanism involving direct interaction with both release and refilling of the inositol 1,4,5-trisphosphate-sensitive Ca2+ pool.
The Biochemical journal 1990;265(1):203-11.
1989: Smith P A; Rorsman P; Ashcroft F M
Modulation of dihydropyridine-sensitive Ca2+ channels by glucose metabolism in mouse pancreatic beta-cells.
Nature 1989;342(6249):550-3.
1989: Rorsman P; Berggren P O; Bokvist K; Ericson H; Möhler H; Ostenson C G; Smith P A
Glucose-inhibition of glucagon secretion involves activation of GABAA-receptor chloride channels.
Nature 1989;341(6239):233-6.
1989: Rorsman P; Arkhammar P; Bokvist K; Hellerström C; Nilsson T; Welsh M; Welsh N; Berggren P O
Failure of glucose to elicit a normal secretory response in fetal pancreatic beta cells results from glucose insensitivity of the ATP-regulated K+ channels.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(12):4505-9.
1989: Nilsson T; Arkhammar P; Rorsman P; Berggren P O
Suppression of insulin release by galanin and somatostatin is mediated by a G-protein. An effect involving repolarization and reduction in cytoplasmic free Ca2+ concentration.
The Journal of biological chemistry 1989;264(2):973-80.
1988: Ashcroft F M; Ashcroft S J; Berggren P O; Betzholz C; Rorsman P; Trube G; Welsh M
Expression of K channels in Xenopus laevis oocytes injected with poly(A+) mRNA from the insulin-secreting beta-cell line, HIT T15.
FEBS letters 1988;239(2):185-9.
1988: Nilsson T; Arkhammar P; Rorsman P; Berggren P O
Inhibition of glucose-stimulated insulin release by alpha 2-adrenoceptor activation is parallelled by both a repolarization and a reduction in cytoplasmic free Ca2+ concentration.
The Journal of biological chemistry 1988;263(4):1855-60.
1988: Rorsman P
Two types of Ca2+ currents with different sensitivities to organic Ca2+ channel antagonists in guinea pig pancreatic alpha 2 cells.
The Journal of general physiology 1988;91(2):243-54.
1988: Rorsman P; Hellman B
Voltage-activated currents in guinea pig pancreatic alpha 2 cells. Evidence for Ca2+-dependent action potentials.
The Journal of general physiology 1988;91(2):223-42.
1987: Wesslén N; Pipeleers D; Van de Winkel M; Rorsman P; Hellman B
Glucose stimulates the entry of Ca2+ into the insulin-producing beta cells but not into the glucagon-producing alpha 2 cells.
Acta physiologica Scandinavica 1987;131(2):230-4.

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