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Stefan Rose-John
This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers
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Network (preview)
38
Heinrich, Peter
29
Grötzinger, Joachim
29
Scheller, Jürgen
28
Müllberg, Jürgen
21
Kallen, Karl-Josef
16
Graeve, Lutz
14
März, Pia
13
Peters, M
12
Galle, Peter
12
Jones, Simon
11
Otten, Uwe
10
Neurath, Markus
10
Fischer, Martina
9
Jostock, Thomas
9
Vollmer, Petra
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All Publications
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2009: Andratsch Manfred; Mair Norbert; Constantin Cristina E; Scherbakov Nadja; Benetti Camilla; Quarta Serena; Vogl Christian; Sailer Claudia A; Uceyler Nurcan; Brockhaus Johannes; Martini Rudolf; Sommer Claudia; Zeilhofer Hanns Ulrich; Müller Werner; Kuner Rohini; Davis John B; Rose-John Stefan; Kress Michaela
A key role for gp130 expressed on peripheral sensory nerves in pathological pain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(43):13473-83.
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2009: Benedict Christian; Scheller Jürgen; Rose-John Stefan; Born Jan; Marshall Lisa
Enhancing influence of intranasal interleukin-6 on slow-wave activity and memory consolidation during sleep.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(10):3629-36.
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2009: Plagmann Ingo; Chalaris Athena; Kruglov Andrei A; Nedospasov Sergei; Rosenstiel Philip; Rose-John Stefan; Scheller Jürgen
Transglutaminase-catalyzed covalent multimerization of Camelidae anti-human TNF single domain antibodies improves neutralizing activity.
Journal of biotechnology 2009;142(2):170-8.
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2009: May Ulrike; Schiffelholz Thomas; Baier Paul Christian; Krueger James M; Rose-John Stefan; Scheller Jürgen
IL-6-trans-signalling increases rapid-eye-movement sleep in rats.
European journal of pharmacology 2009;613(1-3):141-5.
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2009: Baier Paul Christian; May Ulrike; Scheller Jürgen; Rose-John Stefan; Schiffelholz Thomas
Impaired hippocampus-dependent and -independent learning in IL-6 deficient mice.
Behavioural brain research 2009;200(1):192-6.
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2009: Adam Nina; Rabe Björn; Suthaus Jan; Grötzinger Joachim; Rose-John Stefan; Scheller Jürgen
Unraveling viral interleukin-6 binding to gp130 and activation of STAT-signaling pathways independently of the interleukin-6 receptor.
Journal of virology 2009;83(10):5117-26.
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2009: Chen Li; Frister Adrian; Wang Song; Ludwig Andreas; Behr Hagen; Pippig Susanna; Li Beibei; Simm Andreas; Hofmann Britt; Pilowski Claudia; Koch Susanne; Buerke Michael; Rose-John Stefan; Werdan Karl; Loppnow Harald
Interaction of vascular smooth muscle cells and monocytes by soluble factors synergistically enhances IL-6 and MCP-1 production.
American journal of physiology. Heart and circulatory physiology 2009;296(4):H987-96.
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2009: Grivennikov Sergei; Karin Eliad; Terzic Janos; Mucida Daniel; Yu Guann-Yi; Vallabhapurapu Sivakumar; Scheller Jürgen; Rose-John Stefan; Cheroutre Hilde; Eckmann Lars; Karin Michael
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer.
Cancer cell 2009;15(2):103-13.
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2009: Nowell Mari A; Williams Anwen S; Carty Sarah A; Scheller Jürgen; Hayes Anthony J; Jones Gareth W; Richards Peter J; Slinn Simon; Ernst Matthias; Jenkins Brendan J; Topley Nicholas; Rose-John Stefan; Jones Simon A
Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(1):613-22.
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2009: Islam Omedul; Gong Xiandi; Rose-John Stefan; Heese Klaus
Interleukin-6 and neural stem cells: more than gliogenesis.
Molecular biology of the cell 2009;20(1):188-99.
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2009: Rose-John Stefan; Mitsuyama Keiichi; Matsumoto Satoshi; Thaiss Wolfgang M; Scheller Jürgen
Interleukin-6 trans-signaling and colonic cancer associated with inflammatory bowel disease.
Current pharmaceutical design 2009;15(18):2095-103.
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2008: Linker Ralf A; Lühder Fred; Kallen Karl-Josef; Lee De-Hyung; Engelhardt Britta; Rose-John Stefan; Gold Ralf
IL-6 transsignalling modulates the early effector phase of EAE and targets the blood-brain barrier.
Journal of neuroimmunology 2008;205(1-2):64-72.
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2008: Tenhumberg Stephanie; Waetzig Georg H; Chalaris Athena; Rabe Björn; Seegert Dirk; Scheller Jürgen; Rose-John Stefan; Grötzinger Joachim
Structure-guided optimization of the interleukin-6 trans-signaling antagonist sgp130.
The Journal of biological chemistry 2008;283(40):27200-7.
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2008: West Michele A; Prescott Alan R; Chan Kui Ming; Zhou Zhongjun; Rose-John Stefan; Scheller Jürgen; Watts Colin
TLR ligand-induced podosome disassembly in dendritic cells is ADAM17 dependent.
The Journal of cell biology 2008;182(5):993-1005.
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2008: Weigmann Benno; Lehr Hans A; Yancopoulos George; Valenzuela David; Murphy Andrew; Stevens Sean; Schmidt Jan; Galle Peter R; Rose-John Stefan; Neurath Markus F
The transcription factor NFATc2 controls IL-6-dependent T cell activation in experimental colitis.
The Journal of experimental medicine 2008;205(9):2099-110.
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2008: Mudter Jonas; Amoussina Lioubov; Schenk Mirjam; Yu Jingling; Brüstle Anne; Weigmann Benno; Atreya Raja; Wirtz Stefan; Becker Christoph; Hoffman Arthur; Atreya Imke; Biesterfeld Stefan; Galle Peter R; Lehr Hans A; Rose-John Stefan; Mueller Christoph; Lohoff Michael; Neurath Markus F
The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6.
The Journal of clinical investigation 2008;118(7):2415-26.
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2008: Nechemia-Arbely Yael; Barkan Daniel; Pizov Galina; Shriki Anat; Rose-John Stefan; Galun Eithan; Axelrod Jonathan H
IL-6/IL-6R axis plays a critical role in acute kidney injury.
Journal of the American Society of Nephrology : JASN 2008;19(6):1106-15.
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2008: Marino Mariapaola; Scuderi Flavia; Provenzano Carlo; Scheller Jürgen; Rose-John Stefan; Bartoccioni Emanuela
IL-6 regulates MCP-1, ICAM-1 and IL-6 expression in human myoblasts.
Journal of neuroimmunology 2008;196(1-2):41-8.
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2008: Sudarman Enge; Bollati-Fogolín Mariela; Hafner Martin; Müller Werner; Scheller Jürgen; Rose-John Stefan; Eichler Jutta
Synthetic mimetics of the gp130 binding site for viral interleukin-6 as inhibitors of the vIL-6-gp130 interaction.
Chemical biology & drug design 2008;71(5):494-500.
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2008: Walker Francesca; Zhang Hui-Hua; Matthews Vance; Weinstock Janet; Nice Edouard C; Ernst Matthias; Rose-John Stefan; Burgess Antony W
IL6/sIL6R complex contributes to emergency granulopoietic responses in G-CSF- and GM-CSF-deficient mice.
Blood 2008;111(8):3978-85.
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2008: Benrick Anna; Jirholt Pernilla; Wernstedt Ingrid; Gustafsson Maria; Scheller Juergen; Eriksson Anna-Lena; Borén Jan; Hedner Thomas; Ohlsson Claes; Härd Torleif; Rose-John Stefan; Jansson John-Olov
A non-conservative polymorphism in the IL-6 signal transducer (IL6ST)/gp130 is associated with myocardial infarction in a hypertensive population.
Regulatory peptides 2008;146(1-3):189-96.
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2008: Rabe Björn; Chalaris Athena; May Ulrike; Waetzig Georg H; Seegert Dirk; Williams Anwen S; Jones Simon A; Rose-John Stefan; Scheller Jürgen
Transgenic blockade of interleukin 6 transsignaling abrogates inflammation.
Blood 2008;111(3):1021-8.
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2008: Hieronymus Thomas; Ruau David; Ober-Blöbaum Julia; Baek Jea-Hyun; Rolletschek Alexandra; Rose-John Stefan; Wobus Anna M; Müller Albrecht M; Zenke Martin
The transcription factor repertoire of Flt3+ hematopoietic stem cells.
Cells, tissues, organs 2008;188(1-2):103-15.
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2007: Koch Manuel; May Ulrike; Kuhns Stefanie; Drechsler Hauke; Adam Nina; Hattermann Kirsten; Wirtz Stefan; Rose-John Stefan; Scheller Jürgen
Interleukin 27 induces differentiation of neural C6-precursor cells into astrocytes.
Biochemical and biophysical research communications 2007;364(3):483-7.
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2007: Appenheimer Michelle M; Girard Rachael A; Chen Qing; Wang Wan-Chao; Bankert Katherine C; Hardison Joy; Bain Mark D; Ridgley Frank; Sarcione Edward J; Buitrago Sandra; Kothlow Sonja; Kaspers Bernd; Robert Jacques; Rose-John Stefan; Baumann Heinz; Evans Sharon S
Conservation of IL-6 trans-signaling mechanisms controlling L-selectin adhesion by fever-range thermal stress.
European journal of immunology 2007;37(10):2856-67.
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2007: Chalaris Athena; Rabe Björn; Paliga Krzysztof; Lange Hans; Laskay Tamas; Fielding Ceri A; Jones Simon A; Rose-John Stefan; Scheller Jürgen
Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils.
Blood 2007;110(6):1748-55.
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2007: Dominitzki Sabine; Fantini Massimo C; Neufert Clemens; Nikolaev Alexei; Galle Peter R; Scheller Jürgen; Monteleone Giovanni; Rose-John Stefan; Neurath Markus F; Becker Christoph
Cutting edge: trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(4):2041-5.
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2007: Coles Barbara; Fielding Ceri A; Rose-John Stefan; Scheller Jürgen; Jones Simon A; O'Donnell Valerie B
Classic interleukin-6 receptor signaling and interleukin-6 trans-signaling differentially control angiotensin II-dependent hypertension, cardiac signal transducer and activator of transcription-3 activation, and vascular hypertrophy in vivo.
The American journal of pathology 2007;171(1):315-25.
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2007: Finotto Susetta; Eigenbrod Tatjana; Karwot Roman; Boross Ildiko; Doganci Aysefa; Ito Hiroaki; Nishimoto Norihiro; Yoshizaki Kazuyuki; Kishimoto Tadamitsu; Rose-John Stefan; Galle Peter R; Neurath Markus F
Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells.
International immunology 2007;19(6):685-93.
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2007: Rose-John Stefan; Waetzig Georg H; Scheller Jürgen; Grötzinger Joachim; Seegert Dirk
The IL-6/sIL-6R complex as a novel target for therapeutic approaches.
Expert opinion on therapeutic targets 2007;11(5):613-24.
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2007: Yeoh George C T; Ernst Matthias; Rose-John Stefan; Akhurst Barbara; Payne Christine; Long Sarah; Alexander Warren; Croker Ben; Grail Dianne; Matthews Vance B
Opposing roles of gp130-mediated STAT-3 and ERK-1/ 2 signaling in liver progenitor cell migration and proliferation.
Hepatology (Baltimore, Md.) 2007;45(2):486-94.
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2007: Chattopadhyay Souvik; Tracy Erin; Liang Ping; Robledo Olivier; Rose-John Stefan; Baumann Heinz
Interleukin-31 and oncostatin-M mediate distinct signaling reactions and response patterns in lung epithelial cells.
The Journal of biological chemistry 2007;282(5):3014-26.
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2007: Eichenauer Dennis A; Simhadri Vijaya Lakshmi; von Strandmann Elke Pogge; Ludwig Andreas; Matthews Vance; Reiners Katrin S; von Tresckow Bastian; Saftig Paul; Rose-John Stefan; Engert Andreas; Hansen Hinrich P
ADAM10 inhibition of human CD30 shedding increases specificity of targeted immunotherapy in vitro.
Cancer research 2007;67(1):332-8.
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2007: Rose-John Stefan; Schooltink Heidi
Cytokines are a therapeutic target for the prevention of inflammation-induced cancers.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 2007;174():57-66.
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2006: Chen Qing; Fisher Daniel T; Clancy Kristen A; Gauguet Jean-Marc M; Wang Wan-Chao; Unger Emily; Rose-John Stefan; von Andrian Ulrich H; Baumann Heinz; Evans Sharon S
Fever-range thermal stress promotes lymphocyte trafficking across high endothelial venules via an interleukin 6 trans-signaling mechanism.
Nature immunology 2006;7(12):1299-308.
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2006: Mitsuyama Keiichi; Sata Michio; Rose-John Stefan
Interleukin-6 trans-signaling in inflammatory bowel disease.
Cytokine & growth factor reviews 2006;17(6):451-61.
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2006: Scheller Jürgen; Rose-John Stefan
Interleukin-6 and its receptor: from bench to bedside.
Medical microbiology and immunology 2006;195(4):173-83.
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2006: Dimitrov Stoyan; Lange Tanja; Benedict Christian; Nowell Mari A; Jones Simon A; Scheller Jürgen; Rose-John Stefan; Born Jan
Sleep enhances IL-6 trans-signaling in humans.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(12):2174-6.
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2006: Hecht Oliver; Dingley Andrew J; Schwanter Andreas; Ozbek Suat; Rose-John Stefan; Grötzinger Joachim
The solution structure of the membrane-proximal cytokine receptor domain of the human interleukin-6 receptor.
Biological chemistry 2006;387(9):1255-9.
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2006: Kovaleva Marina; Bussmeyer Ingo; Rabe Björn; Grötzinger Joachim; Sudarman Enge; Eichler Jutta; Conrad Udo; Rose-John Stefan; Scheller Jürgen
Abrogation of viral interleukin-6 (vIL-6)-induced signaling by intracellular retention and neutralization of vIL-6 with an anti-vIL-6 single-chain antibody selected by phage display.
Journal of virology 2006;80(17):8510-20.
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2006: Lin Meng; Rose-John Stefan; Grötzinger Joachim; Conrad Udo; Scheller Jürgen
Functional expression of a biologically active fragment of soluble gp130 as an ELP-fusion protein in transgenic plants: purification via inverse transition cycling.
The Biochemical journal 2006;398(3):577-83.
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2006: Mitsuyama K; Matsumoto S; Rose-John S; Suzuki A; Hara T; Tomiyasu N; Handa K; Tsuruta O; Funabashi H; Scheller J; Toyonaga A; Sata M
STAT3 activation via interleukin 6 trans-signalling contributes to ileitis in SAMP1/Yit mice.
Gut 2006;55(9):1263-9.
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2006: Tenhumberg Stephanie; Schuster Björn; Zhu Lixin; Kovaleva Marina; Scheller Jürgen; Kallen Karl-Josef; Rose-John Stefan
gp130 dimerization in the absence of ligand: preformed cytokine receptor complexes.
Biochemical and biophysical research communications 2006;346(3):649-57.
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2006: Rose-John Stefan; Scheller Jürgen; Elson Greg; Jones Simon A
Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer.
Journal of leukocyte biology 2006;80(2):227-36.
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2006: Stuhlmann-Laeisz Christiane; Lang Sigrid; Chalaris Athena; Krzysztof Paliga; Enge Sudarman; Eichler Jutta; Klingmüller Ursula; Samuel Michael; Ernst Matthias; Rose-John Stefan; Scheller Jürgen
Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine-independent growth, and blockade of differentiation of embryonic stem cells.
Molecular biology of the cell 2006;17(7):2986-95.
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2006: Richards Peter J; Nowell Mari A; Horiuchi Sankichi; McLoughlin Rachel M; Fielding Ceri A; Grau Sandra; Yamamoto Naoki; Ehrmann Michael; Rose-John Stefan; Williams Anwen S; Topley Nicholas; Jones Simon A
Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis.
Arthritis and rheumatism 2006;54(5):1662-72.
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2006: Scheller J; Ohnesorge N; Rose-John S
Interleukin-6 trans-signalling in chronic inflammation and cancer.
Scandinavian journal of immunology 2006;63(5):321-9.
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2006: Watt Matthew J; Dzamko Nicolas; Thomas Walter G; Rose-John Stefan; Ernst Matthias; Carling David; Kemp Bruce E; Febbraio Mark A; Steinberg Gregory R
CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK.
Nature medicine 2006;12(5):541-8.
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2006: Campard David; Vasse Marc; Rose-John Stefan; Poyer Florent; Lamacz Marek; Vannier Jean-Pierre
Multilevel regulation of IL-6R by IL-6-sIL-6R fusion protein according to the primitiveness of peripheral blood-derived CD133+ cells.
Stem cells (Dayton, Ohio) 2006;24(5):1302-14.
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2006: Oberg Hans-Heinrich; Wesch Daniela; Grüssel Sandra; Rose-John Stefan; Kabelitz Dieter
Differential expression of CD126 and CD130 mediates different STAT-3 phosphorylation in CD4+CD25- and CD25high regulatory T cells.
International immunology 2006;18(4):555-63.
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2005: Maretzky Thorsten; Schulte Marc; Ludwig Andreas; Rose-John Stefan; Blobel Carl; Hartmann Dieter; Altevogt Peter; Saftig Paul; Reiss Karina
L1 is sequentially processed by two differently activated metalloproteases and presenilin/gamma-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowth.
Molecular and cellular biology 2005;25(20):9040-53.
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2005: Fielding Ceri A; McLoughlin Rachel M; Colmont Chantal S; Kovaleva Marina; Harris Dean A; Rose-John Stefan; Topley Nicholas; Jones Simon A
Viral IL-6 blocks neutrophil infiltration during acute inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(6):4024-9.
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2005: Jones Simon A; Richards Peter J; Scheller Jürgen; Rose-John Stefan
IL-6 transsignaling: the in vivo consequences.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2005;25(5):241-53.
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2005: Klein Christian; Wüstefeld Torsten; Assmus Ulrike; Roskams Tania; Rose-John Stefan; Müller Michael; Manns Michael P; Ernst Mattias; Trautwein Christian
The IL-6-gp130-STAT3 pathway in hepatocytes triggers liver protection in T cell-mediated liver injury.
The Journal of clinical investigation 2005;115(4):860-9.
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2005: Schooltink Heidi; Rose-John Stefan
Designing cytokine variants by phage-display.
Combinatorial chemistry & high throughput screening 2005;8(2):173-9.
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2005: Hieronymus Thomas; Gust Tatjana C; Kirsch Ralf D; Jorgas Thorsten; Blendinger Gitta; Goncharenko Mykola; Supplitt Kamilla; Rose-John Stefan; Müller Albrecht M; Zenke Martin
Progressive and controlled development of mouse dendritic cells from Flt3+CD11b+ progenitors in vitro.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(5):2552-62.
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2005: Schroers Andreas; Hecht Oliver; Kallen Karl-Josef; Pachta Michael; Rose-John Stefan; Grötzinger Joachim
Dynamics of the gp130 cytokine complex: a model for assembly on the cellular membrane.
Protein science : a publication of the Protein Society 2005;14(3):783-90.
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2005: Doganci Aysefa; Eigenbrod Tatjana; Krug Norbert; De Sanctis George T; Hausding Michael; Erpenbeck Veit J; Haddad El-Bdaoui; Lehr Hans A; Schmitt Edgar; Bopp Tobias; Kallen Karl-J; Herz Udo; Schmitt Steffen; Luft Cornelia; Hecht Olaf; Hohlfeld Jens M; Ito Hiroaki; Nishimoto Norihiro; Yoshizaki Kazuyuki; Kishimoto Tadamitsu; Rose-John Stefan; Renz Harald; Neurath Markus F; Galle Peter R; Finotto Susetta
The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo.
The Journal of clinical investigation 2005;115(2):313-25.
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2005: Becker C; Fantini M C; Wirtz S; Nikolaev A; Lehr H A; Galle P R; Rose-John S; Neurath M F
IL-6 signaling promotes tumor growth in colorectal cancer.
Cell cycle (Georgetown, Tex.) 2005;4(2):217-20.
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2005: Scheller Jürgen; Schuster Björn; Hölscher Christoph; Yoshimoto Takayuki; Rose-John Stefan
No inhibition of IL-27 signaling by soluble gp130.
Biochemical and biophysical research communications 2005;326(4):724-8.
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2005: Waetzig Georg H; Rosenstiel Philip; Arlt Alexander; Till Andreas; Bräutigam Karen; Schäfer Heiner; Rose-John Stefan; Seegert Dirk; Schreiber Stefan
Soluble tumor necrosis factor (TNF) receptor-1 induces apoptosis via reverse TNF signaling and autocrine transforming growth factor-beta1.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(1):91-3.
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2004: Klouche Mariam; Carruba Giuseppe; Castagnetta Luigi; Rose-John Stefan
Virokines in the pathogenesis of cancer: focus on human herpesvirus 8.
Annals of the New York Academy of Sciences 2004;1028():329-39.
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2004: Becker Christoph; Fantini Massimo C; Schramm Christoph; Lehr Hans A; Wirtz Stefan; Nikolaev Alexei; Burg Jürgen; Strand Susanne; Kiesslich Ralf; Huber Samuel; Ito Hiroaki; Nishimoto Norihiro; Yoshizaki Kazuyuki; Kishimoto Tadamitsu; Galle Peter R; Blessing Manfred; Rose-John Stefan; Neurath Markus F
TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling.
Immunity 2004;21(4):491-501.
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2004: Curnow S John; Scheel-Toellner Dagmar; Jenkinson Will; Raza Karim; Durrani Omar M; Faint Jeff M; Rauz Saaeha; Wloka Kaska; Pilling Darrell; Rose-John Stefan; Buckley Christopher D; Murray Philip I; Salmon Mike
Inhibition of T cell apoptosis in the aqueous humor of patients with uveitis by IL-6/soluble IL-6 receptor trans-signaling.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(8):5290-7.
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2004: Matthews Vance B; Rose-John Stefan; Yeoh George C T
Genetic manipulations utilizing albumin and alpha-fetoprotein promoter/enhancers affect both hepatocytes and oval cells.
Hepatology (Baltimore, Md.) 2004;40(3):759; author reply 760.
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2004: Budagian Vadim; Bulanova Elena; Orinska Zane; Ludwig Andreas; Rose-John Stefan; Saftig Paul; Borden Ernest C; Bulfone-Paus Silvia
Natural soluble interleukin-15Ralpha is generated by cleavage that involves the tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17).
The Journal of biological chemistry 2004;279(39):40368-75.
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2004: Scheller Jürgen; Kovaleva Marina; Rabe Björn; Eichler Jutta; Kallen Karl-Josef; Rose-John Stefan
Development of a monoclonal antibody-based enzyme-linked immunoabsorbent assay for the binding of gp130 to the IL-6/IL-6R complex and its competitive inhibition.
Journal of immunological methods 2004;291(1-2):93-100.
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2004: März Pia; Probst Alphonse; Lang Sigrid; Schwager Martine; Rose-John Stefan; Otten Uwe; Ozbek Suat
Ataxin-10, the spinocerebellar ataxia type 10 neurodegenerative disorder protein, is essential for survival of cerebellar neurons.
The Journal of biological chemistry 2004;279(34):35542-50.
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2004: Schwantner Andreas; Dingley Andrew J; Ozbek Suat; Hecht Oliver; Rose-John Stefan; Grötzinger Joachim
1H, 15N and 13C backbone assignment of the carboxyl terminal domain of the cytokine binding module of the interleukin-6 receptor.
Journal of biomolecular NMR 2004;29(3):407-8.
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2004: Wang Xu-Ping; Schunck Michael; Kallen Karl-Josef; Neumann Claudia; Trautwein Christian; Rose-John Stefan; Proksch Ehrhardt
The interleukin-6 cytokine system regulates epidermal permeability barrier homeostasis.
The Journal of investigative dermatology 2004;123(1):124-31.
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2004: Abel Soeren; Hundhausen Christian; Mentlein Rolf; Schulte Alexander; Berkhout Theo A; Broadway Neil; Hartmann Dieter; Sedlacek Radek; Dietrich Sebastian; Muetze Barbara; Schuster Bjoern; Kallen Karl-Josef; Saftig Paul; Rose-John Stefan; Ludwig Andreas
The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):6362-72.
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2004: Rose-John Stefan; Neurath Markus F
IL-6 trans-signaling: the heat is on.
Immunity 2004;20(1):2-4.
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2004: Schwantner Andreas; Dingley Andrew J; Ozbek Suat; Rose-John Stefan; Grötzinger Joachim
Direct determination of the interleukin-6 binding epitope of the interleukin-6 receptor by NMR spectroscopy.
The Journal of biological chemistry 2004;279(1):571-6.
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2004: Humphrey Rohan K; Beattie Gillian M; Lopez Ana D; Bucay Nathan; King Charles C; Firpo Meri T; Rose-John Stefan; Hayek Alberto
Maintenance of pluripotency in human embryonic stem cells is STAT3 independent.
Stem cells (Dayton, Ohio) 2004;22(4):522-30.
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2003: Fuchs Martin; Hilfiker Andres; Kaminski Karol; Hilfiker-Kleiner Denise; Guener Zeynep; Klein Gunnar; Podewski Edith; Schieffer Bernhard; Rose-John Stefan; Drexler Helmut
Role of interleukin-6 for LV remodeling and survival after experimental myocardial infarction.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(14):2118-20.
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2003: Matthews Vance; Schuster Björn; Schütze Stefan; Bussmeyer Ingo; Ludwig Andreas; Hundhausen Christian; Sadowski Thorsten; Saftig Paul; Hartmann Dieter; Kallen Karl-Josef; Rose-John Stefan
Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE).
The Journal of biological chemistry 2003;278(40):38829-39.
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2003: Nowell Mari A; Richards Peter J; Horiuchi Sankichi; Yamamoto Naoki; Rose-John Stefan; Topley Nicholas; Williams Anwen S; Jones Simon A
Soluble IL-6 receptor governs IL-6 activity in experimental arthritis: blockade of arthritis severity by soluble glycoprotein 130.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(6):3202-9.
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2003: McLoughlin Rachel M; Witowski Janusz; Robson Rachel L; Wilkinson Thomas S; Hurst Suzanne M; Williams Anwen S; Williams John D; Rose-John Stefan; Jones Simon A; Topley Nicholas
Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation.
The Journal of clinical investigation 2003;112(4):598-607.
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2003: Hundhausen Christian; Misztela Dominika; Berkhout Theo A; Broadway Neil; Saftig Paul; Reiss Karina; Hartmann Dieter; Fahrenholz Falk; Postina Rolf; Matthews Vance; Kallen Karl-Josef; Rose-John Stefan; Ludwig Andreas
The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion.
Blood 2003;102(4):1186-95.
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2003: Rose-John Stefan; Schooltink Heidi
CDP-870. Celltech/Pfizer.
Current opinion in investigational drugs (London, England : 2000) 2003;4(5):588-92.
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2003: Aasland Dorthe; Schuster Björn; Grötzinger Joachim; Rose-John Stefan; Kallen Karl-Josef
Analysis of the leukemia inhibitory factor receptor functional domains by chimeric receptors and cytokines.
Biochemistry 2003;42(18):5244-52.
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2003: Hacker Christine; Kirsch Ralf D; Ju Xin-Sheng; Hieronymus Thomas; Gust Tatjana C; Kuhl Christiane; Jorgas Thorsten; Kurz Steffen M; Rose-John Stefan; Yokota Yoshifumi; Zenke Martin
Transcriptional profiling identifies Id2 function in dendritic cell development.
Nature immunology 2003;4(4):380-6.
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2003: Schuster Björn; Kovaleva Marina; Sun Yi; Regenhard Petra; Matthews Vance; Grötzinger Joachim; Rose-John Stefan; Kallen Karl-Josef
Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF.
The Journal of biological chemistry 2003;278(11):9528-35.
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2003: Schuster Björn; Meinert Werner; Rose-John Stefan; Kallen Karl-Josef
The human interleukin-6 (IL-6) receptor exists as a preformed dimer in the plasma membrane.
FEBS letters 2003;538(1-3):113-6.
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2003: Ju Xin-Sheng; Hacker Christine; Madruga Jaime; Kurz Steffen M; Knespel Siegne; Blendinger Gitta; Rose-John Stefan; Martin Zenke
Towards determining the differentiation program of antigen-presenting dendritic cells by transcriptional profiling.
European journal of cell biology 2003;82(2):75-86.
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2003: Rose-John Stefan
Interleukin-6 biology is coordinated by membrane bound and soluble receptors.
Acta biochimica Polonica 2003;50(3):603-11.
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2002: Lacroix Steve; Chang Leon; Rose-John Stefan; Tuszynski Mark H
Delivery of hyper-interleukin-6 to the injured spinal cord increases neutrophil and macrophage infiltration and inhibits axonal growth.
The Journal of comparative neurology 2002;454(3):213-28.
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2002: Jones Simon A; Rose-John Stefan
The role of soluble receptors in cytokine biology: the agonistic properties of the sIL-6R/IL-6 complex.
Biochimica et biophysica acta 2002;1592(3):251-63.
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2002: Rose-John Stefan
Cytokines come of age.
Biochimica et biophysica acta 2002;1592(3):213-4.
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2002: Löhr H F; Pingel S; Böcher W O; Bernhard H; Herzog-Hauff S; Rose-John S; Galle P R
Reduced virus specific T helper cell induction by autologous dendritic cells in patients with chronic hepatitis B - restoration by exogenous interleukin-12.
Clinical and experimental immunology 2002;130(1):107-14.
-
2002: Rose-John Stefan
GP130 stimulation and the maintenance of stem cells.
Trends in biotechnology 2002;20(10):417-9.
-
2002: Sun Yi; März Pia; Otten Uwe; Ge Jiguang; Rose-John Stefan
The effect of gp130 stimulation on glutamate-induced excitotoxicity in primary hippocampal neurons.
Biochemical and biophysical research communications 2002;295(2):532-9.
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2002: März Pia; Ozbek Suat; Fischer Martina; Voltz Nicole; Otten Uwe; Rose-John Stefan
Differential response of neuronal cells to a fusion protein of ciliary neurotrophic factor/soluble CNTF-receptor and leukemia inhibitory factor.
European journal of biochemistry / FEBS 2002;269(12):3023-31.
-
2002: Schooltink Heidi; Rose-John Stefan
Cytokines as therapeutic drugs.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2002;22(5):505-16.
-
2002: Klouche Mariam; Brockmeyer Norbert; Knabbe Cornelius; Rose-John Stefan
Human herpesvirus 8-derived viral IL-6 induces PTX3 expression in Kaposi's sarcoma cells.
AIDS (London, England) 2002;16(8):F9-18.
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2002: Aasland Dorthe; Oppmann Birgit; Grötzinger Joachim; Rose-John Stefan; Kallen Karl-Josef
The upper cytokine-binding module and the Ig-like domain of the leukaemia inhibitory factor (LIF) receptor are sufficient for a functional LIF receptor complex.
Journal of molecular biology 2002;315(4):637-46.
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2002: Viswanathan Sowmya; Benatar Tania; Rose-John Stefan; Lauffenburger Doug A; Zandstra Peter W
Ligand/receptor signaling threshold (LIST) model accounts for gp130-mediated embryonic stem cell self-renewal responses to LIF and HIL-6.
Stem cells (Dayton, Ohio) 2002;20(2):119-38.
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2001: Böcher W O; Dekel B; Schwerin W; Geissler M; Hoffmann S; Rohwer A; Arditti F; Cooper A; Bernhard H; Berrebi A; Rose-John S; Shaul Y; Galle P R; Löhr H F; Reisner Y
Induction of strong hepatitis B virus (HBV) specific T helper cell and cytotoxic T lymphocyte responses by therapeutic vaccination in the trimera mouse model of chronic HBV infection.
European journal of immunology 2001;31(7):2071-9.
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2001: Hurst S M; Wilkinson T S; McLoughlin R M; Jones S; Horiuchi S; Yamamoto N; Rose-John S; Fuller G M; Topley N; Jones S A
Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation.
Immunity 2001;14(6):705-14.
-
2001: Heinz D; Peters M; Prange R; Gerken G; Rose-John S
Possible role of human interleukin-6 and soluble interleukin-6 receptor in hepatitis B virus infection.
Journal of viral hepatitis 2001;8(3):186-93.
-
2001: Mann A; Breuhahn K; Schirmacher P; Wilhelmi A; Beyer C; Rosenau A; Ozbek S; Rose-John S; Blessing M
Up- and down-regulation of granulocyte/macrophage-colony stimulating factor activity in murine skin increase susceptibility to skin carcinogenesis by independent mechanisms.
Cancer research 2001;61(5):2311-9.
-
2001: Ozbek S; Peters M; Breuhahn K; Mann A; Blessing M; Fischer M; Schirmacher P; Mackiewicz A; Rose-John S
The designer cytokine hyper-IL-6 mediates growth inhibition and GM-CSF-dependent rejection of B16 melanoma cells.
Oncogene 2001;20(8):972-9.
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2001: Althoff K; Müllberg J; Aasland D; Voltz N; Kallen K; Grötzinger J; Rose-John S
Recognition sequences and structural elements contribute to shedding susceptibility of membrane proteins.
The Biochemical journal 2001;353(Pt 3):663-72.
-
2001: Peters M; Solem F; Goldschmidt J; Schirmacher P; Rose-John S
Interleukin-6 and the soluble interleukin-6 receptor induce stem cell factor and Flt-3L expression in vivo and in vitro.
Experimental hematology 2001;29(2):146-55.
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2001: Jostock T; Müllberg J; Ozbek S; Atreya R; Blinn G; Voltz N; Fischer M; Neurath M F; Rose-John S
Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses.
European journal of biochemistry / FEBS 2001;268(1):160-7.
-
2001: Rose-John S
Coordination of interleukin-6 biology by membrane bound and soluble receptors.
Advances in experimental medicine and biology 2001;495():145-51.
-
2001: Otten U; März P; Heese K; Hock C; Kunz D; Rose-John S
Signals regulating neurotrophin expression in glial cells.
Progress in brain research 2001;132():545-54.
-
2000: Peters M; Blinn G; Jostock T; Schirmacher P; Meyer zum Büschenfelde K H; Galle P R; Rose-John S
Combined interleukin 6 and soluble interleukin 6 receptor accelerates murine liver regeneration.
Gastroenterology 2000;119(6):1663-71.
-
2000: Kallen K J; Grötzinger J; Rose-John S
New perspectives on the design of cytokines and growth factors.
Trends in biotechnology 2000;18(11):455-61.
-
2000: Hoischen S H; Vollmer P; März P; Ozbek S; Götze K S; Peschel C; Jostock T; Geib T; Müllberg J; Mechtersheimer S; Fischer M; Grötzinger J; Galle P R; Rose-John S
Human herpes virus 8 interleukin-6 homologue triggers gp130 on neuronal and hematopoietic cells.
European journal of biochemistry / FEBS 2000;267(12):3604-12.
-
2000: Atreya R; Mudter J; Finotto S; Müllberg J; Jostock T; Wirtz S; Schütz M; Bartsch B; Holtmann M; Becker C; Strand D; Czaja J; Schlaak J F; Lehr H A; Autschbach F; Schürmann G; Nishimoto N; Yoshizaki K; Ito H; Kishimoto T; Galle P R; Rose-John S; Neurath M F
Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo.
Nature medicine 2000;6(5):583-8.
-
2000: Althoff K; Reddy P; Voltz N; Rose-John S; Müllberg J
Shedding of interleukin-6 receptor and tumor necrosis factor alpha. Contribution of the stalk sequence to the cleavage pattern of transmembrane proteins.
European journal of biochemistry / FEBS 2000;267(9):2624-31.
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2000: Müllberg J; Geib T; Jostock T; Hoischen S H; Vollmer P; Voltz N; Heinz D; Galle P R; Klouche M; Rose-John S
IL-6 receptor independent stimulation of human gp130 by viral IL-6.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(9):4672-7.
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2000: Bernhard H; Lohmann M; Batten W Y; Metzger J; Löhr H F; Peschel C; zum Büschenfelde K M; Rose-John S
The gp130-stimulating designer cytokine hyper-IL-6 promotes the expansion of human hematopoietic progenitor cells capable to differentiate into functional dendritic cells.
Experimental hematology 2000;28(4):365-72.
-
2000: Klouche M; Rose-John S; Schmiedt W; Bhakdi S
Enzymatically degraded, nonoxidized LDL induces human vascular smooth muscle cell activation, foam cell transformation, and proliferation.
Circulation 2000;101(15):1799-805.
-
2000: Müllberg J; Althoff K; Jostock T; Rose-John S
The importance of shedding of membrane proteins for cytokine biology.
European cytokine network 2000;11(1):27-38.
-
2000: Otten U; März P; Heese K; Hock C; Kunz D; Rose-John S
Cytokines and neurotrophins interact in normal and diseased states.
Annals of the New York Academy of Sciences 2000;917():322-30.
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1999: Klouche M; Bhakdi S; Hemmes M; Rose-John S
Novel path to activation of vascular smooth muscle cells: up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(8):4583-9.
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1999: Kallen K J; Galle P R; Rose-John S
New developments in IL-6 dependent biology and therapy: where do we stand and what are the options?
Expert opinion on investigational drugs 1999;8(9):1327-49.
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1999: März P; Otten U; Rose-John S
Neural activities of IL-6-type cytokines often depend on soluble cytokine receptors.
The European journal of neuroscience 1999;11(9):2995-3004.
-
1999: Grötzinger J; Kernebeck T; Kallen K J; Rose-John S
IL-6 type cytokine receptor complexes: hexamer, tetramer or both?
Biological chemistry 1999;380(7-8):803-13.
-
1999: Vollmer P; Oppmann B; Voltz N; Fischer M; Rose-John S
A role for the immunoglobulin-like domain of the human IL-6 receptor. Intracellular protein transport and shedding.
European journal of biochemistry / FEBS 1999;263(2):438-46.
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1999: März P; Heese K; Dimitriades-Schmutz B; Rose-John S; Otten U
Role of interleukin-6 and soluble IL-6 receptor in region-specific induction of astrocytic differentiation and neurotrophin expression.
Glia 1999;26(3):191-200.
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1999: Kallen K J; Grötzinger J; Lelièvre E; Vollmer P; Aasland D; Renné C; Müllberg J; Myer zum Büschenfelde K H; Gascan H; Rose-John S
Receptor recognition sites of cytokines are organized as exchangeable modules. Transfer of the leukemia inhibitory factor receptor-binding site from ciliary neurotrophic factor to interleukin-6.
The Journal of biological chemistry 1999;274(17):11859-67.
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1999: Jostock T; Blinn G; Renné C; Kallen K J; Rose-John S; Müllberg J
Immunoadhesins of interleukin-6 and the IL-6/soluble IL-6R fusion protein hyper-IL-6.
Journal of immunological methods 1999;223(2):171-83.
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1999: Thier M; März P; Otten U; Weis J; Rose-John S
Interleukin-6 (IL-6) and its soluble receptor support survival of sensory neurons.
Journal of neuroscience research 1999;55(4):411-22.
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1999: Müllberg J; Vollmer P; Althoff K; März P; Rose-John S
Generation and function of the soluble interleukin-6 receptor.
Biochemical Society transactions 1999;27(2):211-9.
-
1999: Rakemann T; Niehof M; Kubicka S; Fischer M; Manns M P; Rose-John S; Trautwein C
The designer cytokine hyper-interleukin-6 is a potent activator of STAT3-dependent gene transcription in vivo and in vitro.
The Journal of biological chemistry 1999;274(3):1257-66.
-
1998: Peters M; Müller A M; Rose-John S
Interleukin-6 and soluble interleukin-6 receptor: direct stimulation of gp130 and hematopoiesis.
Blood 1998;92(10):3495-504.
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1998: Renné C; Kallen K J; Müllberg J; Jostock T; Grötzinger J; Rose-John S
A new type of cytokine receptor antagonist directly targeting gp130.
The Journal of biological chemistry 1998;273(42):27213-9.
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1998: Peters M; Blinn G; Solem F; Fischer M; Meyer zum Büschenfelde K H; Rose-John S
In vivo and in vitro activities of the gp130-stimulating designer cytokine Hyper-IL-6.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(7):3575-81.
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1998: Krebs B; Ackermann B; Rose-John S
Specific targeting of cytokine-secreting cells: a bispecific diabody recognizing human interleukin-6 and CD3 induces T cell-mediated killing.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1998;18(9):783-91.
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1998: Schirmacher P; Peters M; Ciliberto G; Blessing M; Lotz J; Meyer zum Büschenfelde K H; Rose-John S
Hepatocellular hyperplasia, plasmacytoma formation, and extramedullary hematopoiesis in interleukin (IL)-6/soluble IL-6 receptor double-transgenic mice.
The American journal of pathology 1998;153(2):639-48.
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1998: Ozbek S; Grötzinger J; Krebs B; Fischer M; Wollmer A; Jostock T; Müllberg J; Rose-John S
The membrane proximal cytokine receptor domain of the human interleukin-6 receptor is sufficient for ligand binding but not for gp130 association.
The Journal of biological chemistry 1998;273(33):21374-9.
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1998: März P; Cheng J G; Gadient R A; Patterson P H; Stoyan T; Otten U; Rose-John S
Sympathetic neurons can produce and respond to interleukin 6.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(6):3251-6.
-
1998: Krebs B; Griffin H; Winter G; Rose-John S
Recombinant human single chain Fv antibodies recognizing human interleukin-6. Specific targeting of cytokine-secreting cells.
The Journal of biological chemistry 1998;273(5):2858-65.
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1997: März P; Heese K; Hock C; Golombowski S; Müller-Spahn F; Rose-John S; Otten U
Interleukin-6 (IL-6) and soluble forms of IL-6 receptors are not altered in cerebrospinal fluid of Alzheimer's disease patients.
Neuroscience letters 1997;239(1):29-32.
-
1997: März P; Herget T; Lang E; Otten U; Rose-John S
Activation of gp130 by IL-6/soluble IL-6 receptor induces neuronal differentiation.
The European journal of neuroscience 1997;9(12):2765-73.
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1997: Peters M; Odenthal M; Schirmacher P; Blessing M; Fattori E; Ciliberto G; Meyer zum Buschenfelde K H; Rose-John S
Soluble IL-6 receptor leads to a paracrine modulation of the IL-6-induced hepatic acute phase response in double transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(3):1474-81.
-
1997: Kallen K J; zum Büschenfelde K H; Rose-John S
The therapeutic potential of interleukin-6 hyperagonists and antagonists.
Expert opinion on investigational drugs 1997;6(3):237-66.
-
1997: Knolle P A; Löser E; Protzer U; Duchmann R; Schmitt E; zum Büschenfelde K H; Rose-John S; Gerken G
Regulation of endotoxin-induced IL-6 production in liver sinusoidal endothelial cells and Kupffer cells by IL-10.
Clinical and experimental immunology 1997;107(3):555-61.
-
1997: Fischer M; Goldschmitt J; Peschel C; Brakenhoff J P; Kallen K J; Wollmer A; Grötzinger J; Rose-John S
I. A bioactive designer cytokine for human hematopoietic progenitor cell expansion.
Nature biotechnology 1997;15(2):142-5.
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1997: Peters M; Schirmacher P; Goldschmitt J; Odenthal M; Peschel C; Fattori E; Ciliberto G; Dienes H P; Meyer zum Büschenfelde K H; Rose-John S
Extramedullary expansion of hematopoietic progenitor cells in interleukin (IL)-6-sIL-6R double transgenic mice.
The Journal of experimental medicine 1997;185(4):755-66.
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1997: Grötzinger J; Kurapkat G; Wollmer A; Kalai M; Rose-John S
The family of the IL-6-type cytokines: specificity and promiscuity of the receptor complexes.
Proteins 1997;27(1):96-109.
-
1996: Peters M; Meyer zum Büschenfelde K H; Rose-John S
The function of the soluble IL-6 receptor in vivo.
Immunology letters 1996;54(2-3):177-84.
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1996: Vollmer P; Peters M; Ehlers M; Yagame H; Matsuba T; Kondo M; Yasukawa K; Büschenfelde K H; Rose-John S
Yeast expression of the cytokine receptor domain of the soluble interleukin-6 receptor.
Journal of immunological methods 1996;199(1):47-54.
-
1996: Brakenhoff J P; Bos H K; Grötzinger J; Rose-John S; Aarden L A
Identification of residues in the putative 5th helical region of human interleukin-6, important for activation of the IL-6 signal transducer, gp130.
FEBS letters 1996;395(2-3):235-40.
-
1996: Cichy J; Rose-John S; Pryjma J; Travis J
Effect of soluble interleukin-6 receptor on interleukin-6 synthesis in human skin fibroblasts.
Biochemical and biophysical research communications 1996;227(2):318-21.
-
1996: Oppmann B; Stoyan T; Fischer M; Voltz N; März P; Rose-John S
Alternative assay procedures for cytokines and soluble receptors of the IL-6 family.
Journal of immunological methods 1996;195(1-2):153-9.
-
1996: Vollmer P; Walev I; Rose-John S; Bhakdi S
Novel pathogenic mechanism of microbial metalloproteinases: liberation of membrane-anchored molecules in biologically active form exemplified by studies with the human interleukin-6 receptor.
Infection and immunity 1996;64(9):3646-51.
-
1996: Ehlers M; Grötzinger J; Fischer M; Bos H K; Brakenhoff J P; Rose-John S
Identification of single amino acid residues of human IL-6 involved in receptor binding and signal initiation.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1996;16(8):569-76.
-
1996: Walev I; Vollmer P; Palmer M; Bhakdi S; Rose-John S
Pore-forming toxins trigger shedding of receptors for interleukin 6 and lipopolysaccharide.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(15):7882-7.
-
1996: Kalai M; Montero-Julian F A; Grötzinger J; Wollmer A; Morelle D; Brochier J; Rose-John S; Heinrich P C; Brailly H; Content J
Participation of two Ser-Ser-Phe-Tyr repeats in interleukin-6 (IL-6)-binding sites of the human IL-6 receptor.
European journal of biochemistry / FEBS 1996;238(3):714-23.
-
1996: Roeb E; Rose-John S
[Cytokines: biology and therapeutic relevance]
Deutsche medizinische Wochenschrift (1946) 1996;121(24):803-9.
-
1996: Peters M; Jacobs S; Ehlers M; Vollmer P; Müllberg J; Wolf E; Brem G; Meyer zum Büschenfelde K H; Rose-John S
The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6.
The Journal of experimental medicine 1996;183(4):1399-406.
-
1996: Kasza A; Korpula-Mastalerz R; Rose-John S; Dubin A
Biosynthesis and distribution of leucocyte elastase inhibitor. Production of recombinant inhibitor.
Acta biochimica Polonica 1996;43(3):497-501.
-
1995: Simon R; Thier M; Krüttgen A; Rose-John S; Weiergräber O; Heinrich P C; Schröder J M; Weis J
Human CNTF and related cytokines: effects on DRG neurone survival.
Neuroreport 1995;7(1):153-7.
-
1995: Weiergräber O; Hemmann U; Küster A; Müller-Newen G; Schneider J; Rose-John S; Kurschat P; Brakenhoff J P; Hart M H; Stabel S
Soluble human interleukin-6 receptor. Expression in insect cells, purification and characterization.
European journal of biochemistry / FEBS 1995;234(2):661-9.
-
1995: Kurschat P; Graeve L; Erren A; Gatsios P; Rose-John S; Roeb E; Tschesche H; Koj A; Heinrich P C
Expression of a biologically active murine tissue inhibitor of metalloproteinases-1 (TIMP-1) in baculovirus-infected insect cells. Purification and tissue distribution in the rat.
European journal of biochemistry / FEBS 1995;234(2):485-91.
-
1995: Peters M; Roeb E; Pennica D; Meyer zum Büschenfelde K H; Rose-John S
A new hepatocyte stimulating factor: cardiotrophin-1 (CT-1).
FEBS letters 1995;372(2-3):177-80.
-
1995: de Hon F D; Klaasse Bos H K; Ebeling S B; Grötzinger J; Kurapkat G; Rose-John S; Aarden L A; Brakenhoff J P
Leucine-58 in the putative 5th helical region of human interleukin (IL)-6 is important for activation of the IL-6 signal transducer, gp130.
FEBS letters 1995;369(2-3):187-91.
-
1995: Roeb E; Graeve L; Müllberg J; Matern S; Rose-John S
TIMP-1 protein expression is stimulated by IL-1 beta and IL-6 in primary rat hepatocytes.
Annals of the New York Academy of Sciences 1995;762():462-4.
-
1995: Dittrich E; Gerhartz C; Rose-John S; Müllberg J; Stoyan T; Heinrich P C; Graeve L
A region within the cytoplasmic domain of the interleukin-6 signal transducer gp130 important for ligand-induced endocytosis of the IL-6 receptor.
Annals of the New York Academy of Sciences 1995;762():410-2.
-
1995: Ehlers M; Grötzinger J; de Hon F D; Müllberg J; Brakenhoff J P; Wollmer A; Rose-John S
Residues 77-95 of the human interleuken-6 protein are responsible for receptor binding and residues 41-56 for signal transduction.
Annals of the New York Academy of Sciences 1995;762():400-2.
-
1995: Mackiewicz A; Wiznerowicz M; Roeb E; Nowak J; Pawlowski T; Baumann H; Heinrich P C; Rose-John S
Interleukin-6-type cytokines and their receptors for gene therapy of melanoma.
Annals of the New York Academy of Sciences 1995;762():361-73; discussion 373-4.
-
1995: Rose-John S; Ehlers M; Grötzinger J; Müllberg J
The soluble interleukin-6 receptor.
Annals of the New York Academy of Sciences 1995;762():207-20; discussion 220-1.
-
1995: de Hon F D; ten Boekel E; Herrman J; Clement C; Ehlers M; Taga T; Yasukawa K; Ohsugi Y; Kishimoto T; Rose-John S
Functional distinction of two regions of human interleukin 6 important for signal transduction via gp130.
Cytokine 1995;7(5):398-407.
-
1995: Heinrich P C; Graeve L; Rose-John S; Schneider-Mergener J; Dittrich E; Erren A; Gerhartz C; Hemann U; Lütticken C; Wegenka U
Membrane-bound and soluble interleukin-6 receptor: studies on structure, regulation of expression, and signal transduction.
Annals of the New York Academy of Sciences 1995;762():222-36; discussion 236-7.
-
1995: Mackiewicz A; Górny A; Laciak M; Malicki J; Murawa P; Nowak J; Wiznerowicz M; Hawley R G; Heinrich P C; Rose-John S
Gene therapy of human melanoma. Immunization of patients with autologous tumor cells admixed with allogeneic melanoma cells secreting interleukin 6 and soluble interleukin 6 receptor.
Human gene therapy 1995;6(6):805-11.
-
1995: Ehlers M; de Hon F D; Bos H K; Horsten U; Kurapkat G; van De Leur H S; Grötzinger J; Wollmer A; Brakenhoff J P; Rose-John S
Combining two mutations of human interleukin-6 that affect gp130 activation results in a potent interleukin-6 receptor antagonist on human myeloma cells.
The Journal of biological chemistry 1995;270(14):8158-63.
-
1995: Thier M; Simon R; Krüttgen A; Rose-John S; Heinrich P C; Schröder J M; Weis J
Site-directed mutagenesis of human CNTF: functional analysis of recombinant variants.
Journal of neuroscience research 1995;40(6):826-35.
-
1995: Horsten U; Schmitz-Van de Leur H; Müllberg J; Heinrich P C; Rose-John S
The membrane distal half of gp130 is responsible for the formation of a ternary complex with IL-6 and the IL-6 receptor.
FEBS letters 1995;360(1):43-6.
-
1995: Mackiewicz A; Wiznerowicz M; Roeb E; Karczewska A; Nowak J; Heinrich P C; Rose-John S
Soluble interleukin 6 receptor is biologically active in vivo.
Cytokine 1995;7(2):142-9.
-
1995: Roeb E; Rose-John S; Erren A; Edwards D R; Matern S; Graeve L; Heinrich P C
Tissue inhibitor of metalloproteinases-2 (TIMP-2) in rat liver cells is increased by lipopolysaccharide and prostaglandin E2.
FEBS letters 1995;357(1):33-6.
-
1994: de Hon F D; Ehlers M; Rose-John S; Ebeling S B; Bos H K; Aarden L A; Brakenhoff J P
Development of an interleukin (IL) 6 receptor antagonist that inhibits IL-6-dependent growth of human myeloma cells.
The Journal of experimental medicine 1994;180(6):2395-400.
-
1994: Ehlers M; Grötzinger J; deHon F D; Müllberg J; Brakenhoff J P; Liu J; Wollmer A; Rose-John S
Identification of two novel regions of human IL-6 responsible for receptor binding and signal transduction.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(4):1744-53.
-
1994: Roeb E; Graeve L; Müllberg J; Matern S; Rose-John S
TIMP-1 protein expression is stimulated by IL-1 beta and IL-6 in primary rat hepatocytes.
FEBS letters 1994;349(1):45-9.
-
1994: Dittrich E; Rose-John S; Gerhartz C; Müllberg J; Stoyan T; Yasukawa K; Heinrich P C; Graeve L
Identification of a region within the cytoplasmic domain of the interleukin-6 (IL-6) signal transducer gp130 important for ligand-induced endocytosis of the IL-6 receptor.
The Journal of biological chemistry 1994;269(29):19014-20.
-
1994: Gerhartz C; Dittrich E; Stoyan T; Rose-John S; Yasukawa K; Heinrich P C; Graeve L
Biosynthesis and half-life of the interleukin-6 receptor and its signal transducer gp130.
European journal of biochemistry / FEBS 1994;223(1):265-74.
-
1994: Rose-John S; Heinrich P C
Soluble receptors for cytokines and growth factors: generation and biological function.
The Biochemical journal 1994;300 ( Pt 2)():281-90.
-
1994: Müllberg J; Oberthür W; Lottspeich F; Mehl E; Dittrich E; Graeve L; Heinrich P C; Rose-John S
The soluble human IL-6 receptor. Mutational characterization of the proteolytic cleavage site.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(10):4958-68.
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1994: Brakenhoff J P; de Hon F D; Fontaine V; ten Boekel E; Schooltink H; Rose-John S; Heinrich P C; Content J; Aarden L A
Development of a human interleukin-6 receptor antagonist.
The Journal of biological chemistry 1994;269(1):86-93.
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1993: Rose-John S; Schooltink H; Schmitz-Van de Leur H; Müllberg J; Heinrich P C; Graeve L
Intracellular retention of interleukin-6 abrogates signaling.
The Journal of biological chemistry 1993;268(29):22084-91.
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1993: Müllberg J; Dittrich E; Graeve L; Gerhartz C; Yasukawa K; Taga T; Kishimoto T; Heinrich P C; Rose-John S
Differential shedding of the two subunits of the interleukin-6 receptor.
FEBS letters 1993;332(1-2):174-8.
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1993: Stoyan T; Michaelis U; Schooltink H; Van Dam M; Rudolph R; Heinrich P C; Rose-John S
Recombinant soluble human interleukin-6 receptor. Expression in Escherichia coli, renaturation and purification.
European journal of biochemistry / FEBS 1993;216(1):239-45.
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1993: van Dam M; Müllberg J; Schooltink H; Stoyan T; Brakenhoff J P; Graeve L; Heinrich P C; Rose-John S
Structure-function analysis of interleukin-6 utilizing human/murine chimeric molecules. Involvement of two separate domains in receptor binding.
The Journal of biological chemistry 1993;268(20):15285-90.
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1993: Kordula T; Dubin A; Schooltink H; Koj A; Heinrich P C; Rose-John S
Molecular cloning and expression of an intracellular serpin: an elastase inhibitor from horse leucocytes.
The Biochemical journal 1993;293 ( Pt 1)():187-93.
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1993: Pietzko D; Zohlnhöfer D; Graeve L; Fleischer D; Stoyan T; Schooltink H; Rose-John S; Heinrich P C
The hepatic interleukin-6 receptor. Studies on its structure and regulation by phorbol 12-myristate 13-acetate-dexamethasone.
The Journal of biological chemistry 1993;268(6):4250-8.
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1993: Müllberg J; Schooltink H; Stoyan T; Günther M; Graeve L; Buse G; Mackiewicz A; Heinrich P C; Rose-John S
The soluble interleukin-6 receptor is generated by shedding.
European journal of immunology 1993;23(2):473-80.
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1992: Müllberg J; Schooltink H; Stoyan T; Heinrich P C; Rose-John S
Protein kinase C activity is rate limiting for shedding of the interleukin-6 receptor.
Biochemical and biophysical research communications 1992;189(2):794-800.
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1992: Schooltink H; Stoyan T; Roeb E; Heinrich P C; Rose-John S
Ciliary neurotrophic factor induces acute-phase protein expression in hepatocytes.
FEBS letters 1992;314(3):280-4.
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1992: Kordula T; Güttgemann I; Rose-John S; Roeb E; Osthues A; Tschesche H; Koj A; Heinrich P C; Graeve L
Synthesis of tissue inhibitor of metalloproteinase-1 (TIMP-1) in human hepatoma cells (HepG2). Up-regulation by interleukin-6 and transforming growth factor beta 1.
FEBS letters 1992;313(2):143-7.
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1992: Mackiewicz A; Schooltink H; Heinrich P C; Rose-John S
Complex of soluble human IL-6-receptor/IL-6 up-regulates expression of acute-phase proteins.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(6):2021-7.
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1992: Mackiewicz A; Rose-John S; Schooltink H; Laciak M; Górny A; Heinrich P C
Soluble human interleukin-6-receptor modulates interleukin-6-dependent N-glycosylation of alpha 1-protease inhibitor secreted by HepG2 cells.
FEBS letters 1992;306(2-3):257-61.
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1992: Zohlnhöfer D; Graeve L; Rose-John S; Schooltink H; Dittrich E; Heinrich P C
The hepatic interleukin-6 receptor. Down-regulation of the interleukin-6 binding subunit (gp80) by its ligand.
FEBS letters 1992;306(2-3):219-22.
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1992: Schooltink H; Schmitz-Van de Leur H; Heinrich P C; Rose-John S
Up-regulation of the interleukin-6-signal transducing protein (gp130) by interleukin-6 and dexamethasone in HepG2 cells.
FEBS letters 1992;297(3):263-5.
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1992: Kordula T; Rose-John S; Heinrich P C; Koj A
Interferon-gamma regulates alpha 2-macroglobulin and alpha 1-antichymotrypsin expression on the pretranslational level in HepG2 cells.
Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society 1992;30(4):147-9.
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1991: Schooltink H; Stoyan T; Lenz D; Schmitz H; Hirano T; Kishimoto T; Heinrich P C; Rose-John S
Structural and functional studies on the human hepatic interleukin-6 receptor. Molecular cloning and overexpression in HepG2 cells.
The Biochemical journal 1991;277 ( Pt 3)():659-64.
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1991: Lütticken C; Krüttgen A; Möller C; Heinrich P C; Rose-John S
Evidence for the importance of a positive charge and an alpha-helical structure of the C-terminus for biological activity of human IL-6.
FEBS letters 1991;282(2):265-7.
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1991: Rose-John S; Hipp E; Lenz D; Legrés L G; Korr H; Hirano T; Kishimoto T; Heinrich P C
Structural and functional studies on the human interleukin-6 receptor. Binding, cross-linking, internalization, and degradation of interleukin-6 by fibroblasts transfected with human interleukin-6-receptor cDNA.
The Journal of biological chemistry 1991;266(6):3841-6.
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1990: Krüttgen A; Rose-John S; Dufhues G; Bender S; Lütticken C; Freyer P; Heinrich P C
The three carboxy-terminal amino acids of human interleukin-6 are essential for its biological activity.
FEBS letters 1990;273(1-2):95-8.
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1990: Rose-John S; Schooltink H; Lenz D; Hipp E; Dufhues G; Schmitz H; Schiel X; Hirano T; Kishimoto T; Heinrich P C
Studies on the structure and regulation of the human hepatic interleukin-6 receptor.
European journal of biochemistry / FEBS 1990;190(1):79-83.
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1990: Schiel X; Rose-John S; Dufhues G; Schooltink H; Gross V; Heinrich P C
Microheterogeneity of human interleukin 6 synthesized by transfected NIH/3T3 cells: comparison with human monocytes, fibroblasts and endothelial cells.
European journal of immunology 1990;20(4):883-7.
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1990: Krüttgen A; Rose-John S; Möller C; Wroblowski B; Wollmer A; Müllberg J; Hirano T; Kishimoto T; Heinrich P C
Structure-function analysis of human interleukin-6. Evidence for the involvement of the carboxy-terminus in function.
FEBS letters 1990;262(2):323-6.
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