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Stefan Rose-John

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Clive McKimmie; Robert J B Nibbs; Stefan Rose-John; Mark D Singh; Rachel Wheat; Kay Hewit; Michelle Le Brocq; Kit Ming Lee; Oscar Lopez-Franco; Andrew H Baker; David J Blackbourn; Gerard J Graham
An analysis of the function and expression of D6 on lymphatic endothelial cells.
Stefan Rose-John
ADAM17, shedding, TACE as therapeutic targets.
Olga Braun; Christin Dewitz; Katja Möller-Hackbarth; Jürgen Scheller; Thomas Schiffelholz; Paul Christian Baier; Stefan Rose-John
Effects of blockade of peripheral interleukin-6 trans-signaling on hippocampus-dependent and independent memory in mice.

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2013: Clive McKimmie; Robert J B Nibbs; Stefan Rose-John; Mark D Singh; Rachel Wheat; Kay Hewit; Michelle Le Brocq; Kit Ming Lee; Oscar Lopez-Franco; Andrew H Baker; David J Blackbourn; Gerard J Graham
An analysis of the function and expression of D6 on lymphatic endothelial cells.
Blood 2013;121(18):3768-77.
2013: Stefan Rose-John
ADAM17, shedding, TACE as therapeutic targets.
Pharmacological research : the official journal of the Italian Pharmacological Society 2013;71():19-22.
2013: Olga Braun; Christin Dewitz; Katja Möller-Hackbarth; Jürgen Scheller; Thomas Schiffelholz; Paul Christian Baier; Stefan Rose-John
Effects of blockade of peripheral interleukin-6 trans-signaling on hippocampus-dependent and independent memory in mice.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2013;33(5):254-60.
2013: Yael Nechemia-Arbely; Stefan Rose-John; Seymour Rosen; Christian Rosenberger; Ahuva Shina; Anat Shriki; Jonathan H Axelrod; Eithan Galun; Carmit Geva; Mogher Khamaisi; Stephen Klaus; Robert Koesters; Samuel N Heyman
In vivo evidence suggesting reciprocal renal hypoxia-inducible factor-1 upregulation and signal transducer and activator of transcription 3 activation in response to hypoxic and non-hypoxic stimuli.
Clinical and experimental pharmacology & physiology 2013;40(4):262-72.
2013: Antje Schütt; Martin Zacharias; Nico Schneider; Joachim Grötzinger; Silke Horn; Stefan Rose-John; Dirk Schmidt-Arras
gp130 activation is regulated by D2-D3 interdomain connectivity.
The Biochemical journal 2013;450(3):487-96.
2013: Hong Zhang; Walter Halangk; Magdalena U Kurkowski; Marina Lesina; Joseph P Mizgerd; Patrick Neuhöfer; Björn Rabe; Sara Regnér; Stefan Rose-John; Dieter Saur; Roland M Schmid; Liang Song; Henrik Thorlacius; Matthias Treiber; Thomas Wartmann; Gregor Weirich; Akihiko Yoshimura; Hana Algül
IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality.
The Journal of clinical investigation 2013;123(3):1019-31.
2013: Lin-Hung Wei; Min-Wei Chen; Shee-Uan Chen; Chia-Hung Chou; Min-Liang Kuo; Stefan Rose-John; Yu-Shih Yang
The role of IL-6 trans-signaling in vascular leakage: implications for ovarian hyperstimulation syndrome in a murine model.
The Journal of clinical endocrinology and metabolism 2013;98(3):E472-84.
2013: Ahmad Trad; Kosuke Yamamoto; Christine Desel; Hinrich P Hansen; Nina Hedemann; Katja Klausz; Hilmar Lemke; Inken Lorenzen; André Mauermann; Matthias Peipp; Stefan Rose-John; Mohammad Shomali; Joachim Grötzinger
ADAM17-overexpressing breast cancer cells selectively targeted by antibody-toxin conjugates.
Cancer immunology, immunotherapy : CII 2013;62(3):411-21.
2013: Stefanie Derer; Nils Grabe; Joachim Groetzinger; Robert Haesler; Sascha Jung; Tanja Kuehbacher; Susanna Nikolaus; Stefan Rose-John; Philip Rosenstiel; Christian Sina; Andreas Till; Stefan Schreiber
mTNF reverse signalling induced by TNFα antagonists involves a GDF-1 dependent pathway: implications for Crohn's disease.
Gut 2013;62(3):376-86.
2013: Christoph Garbers; Joachim Grötzinger; Christoph Hölscher; Inken Lorenzen; Stefan Rose-John; Jan Sommer; Björn Spudy; Georg H Waetzig; Samadhi Aparicio-Siegmund; Jürgen Scheller
An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer.
The Journal of biological chemistry 2013;288(6):4346-54.
2013: Eileen Magbanua; Günter Mayer; Cindy Meyer; Stefan Rose-John; Andrew E Torda; Tijana Zivkovic; Niklas Beschorner; Joachim Grötzinger; Björn Hansen; Joachim Hauber; Inken Lorenzen; Ulrich Hahn
d(GGGT) 4 and r(GGGU) 4 are both HIV-1 inhibitors and interleukin-6 receptor aptamers.
RNA biology 2013;10(2):216-27.
2013: Unni Krishna S R L Samavedam; Jürgen Scheller; Enno Schmidt; Jürgen Westermann; Detlef Zillikens; Yask Gupta; Marcel F Jonkman; Kathrin Kalies; Stefan Rose-John; Hengameh Sadeghi; Ralf J Ludwig
Recombinant IL-6 treatment protects mice from organ specific autoimmune disease by IL-6 classical signalling-dependent IL-1ra induction.
Journal of autoimmunity 2013;40():74-85.
2013: Judith Hoge; Nathalie Jänner; Athena Chalaris; Daniel R Engel; Stefan Rose-John; Jürgen Scheller; Valéa Schumacher; Oliver M Steinmetz; Isabell Yan; Hans-Willi Mittrücker
IL-6 controls the innate immune response against Listeria monocytogenes via classical IL-6 signaling.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(2):703-11.
2013: Eithan Galun; Stefan Rose-John
The regenerative activity of interleukin-6.
Methods in molecular biology (Clifton, N.J.) 2013;982():59-77.
2013: Tamara Jefferson; Viktor Magdolen; Wladislaw Maier; Verena V Metz; Anke Ohler; Christopher M Overall; Claus U Pietrzik; Rolf Postina; Stefan Rose-John; Erwin E Sterchi; Heiko Traupe; Caroline Bellac; Judith S Bond; Claudia Broder; Athena Chalaris; Jana Hedrich; Arumugam Jayakumar; Ulrich auf dem Keller; Christoph Becker-Pauly
The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10.
Cellular and molecular life sciences : CMLS 2013;70(2):309-33.
2012: Jan Sodenkamp; Georg H Waetzig; Stefan Ehlers; Joachim Grötzinger; Stefan Rose-John; Jürgen Scheller; Dirk Seegert; Christoph Hölscher
Therapeutic targeting of interleukin-6 trans-signaling does not affect the outcome of experimental tuberculosis.
Immunobiology 2012;217(10):996-1004.
2012: Katharina Gerlach; Thomas Gerlach; Hans A Lehr; Markus F Neurath; Alexei Nikolaev; Stefan Rose-John; Raja Atreya; Carolin Daniel; Benno Weigmann
Transcription factor NFATc2 controls the emergence of colon cancer associated with IL-6-dependent colitis.
Cancer research 2012;72(17):4340-50.
2012: Robert J J O'Donoghue; Cecilia M Prêle; Carl D Richards; Stefan Rose-John; Philip Stumbles; Stefan Thiem; Ross Vlahos; Bo Wang; Hong Jian Zhu; Gary P Anderson; Steven Bozinovski; Matthias R Ernst; Andrew G Jarnicki; Jessica Jones; Darryl A Knight; Hui Ling Lau; Geoffrey J Laurent; Robin J McAnulty; Brent S McKenzie; Steven E Mutsaers
Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis.
EMBO molecular medicine 2012;4(9):939-51.
2012: Jürgen Scheller; Stefan Rose-John
The interleukin 6 pathway and atherosclerosis.
Lancet 2012;380(9839):338.
2012: Kosuke Yamamoto; Jürgen Scheller; Ahmad Trad; Anja Baumgart; Athena Chalaris; Tobias Dechow; Joachim Grötzinger; Linda Hüske; Inken Lorenzen; Stefan Rose-John
A novel bispecific single-chain antibody for ADAM17 and CD3 induces T-cell-mediated lysis of prostate cancer cells.
The Biochemical journal 2012;445(1):135-44.
2012: Christoph Garbers; Joachim Grötzinger; Heike M Hermanns; Gerhard Müller-Newen; Stefan Rose-John; Fred Schaper; Jürgen Scheller
Plasticity and cross-talk of interleukin 6-type cytokines.
Cytokine & growth factor reviews 2012;23(3):85-97.
2012: Andrzej mackiewicz; Jacek Mackiewicz; Stefan Rose-John; Maciej Wiznerowicz; Piotr J Wysocki; Tomasz Burzykowski; D Izycki; M Kapcinska; M Laciak; Aldona Karczewska-Dzionk
Long-term survival of high-risk melanoma patients immunized with a Hyper-IL-6-modified allogeneic whole-cell vaccine after complete resection.
Expert opinion on investigational drugs 2012;21(6):773-83.
2012: Kristin M Seré; Piritta Felker; Thomas Hieronymus; Theresa Klisch; Qiong Lin; Inga Ortseifer; Nina Rehage; Stefan Rose-John; Martin Zenke
Dendritic cell lineage commitment is instructed by distinct cytokine signals.
European journal of cell biology 2012;91(6-7):515-23.
2012: Jan Suthaus; Van S Tompkins; Giovanna Tosato; Jürgen Scheller; Christiane Stuhlmann-Laeisz; Siegfried Janz; Wolfram Klapper; Timothy R Rosean; Stefan Rose-John
HHV-8-encoded viral IL-6 collaborates with mouse IL-6 in the development of multicentric Castleman disease in mice.
Blood 2012;119(22):5173-81.
2012: Inken Lorenzen; Stefan Rose-John; Jürgen Scheller; Ahmad Trad; Stefan Düsterhöft; Christoph Garbers; Juliane Lokau; Joachim Grötzinger
The membrane-proximal domain of A Disintegrin and Metalloprotease 17 (ADAM17) is responsible for recognition of the interleukin-6 receptor and interleukin-1 receptor II.
FEBS letters 2012;586(8):1093-100.
2012: Jan Sommer; Jan Suthaus; Elena Volpi; Georg H Waetzig; Marten Bernhardt; Timo Effenberger; Doreen M Floss; Christoph Garbers; Stefan Rose-John; Jürgen Scheller
Constitutively active mutant gp130 receptor protein from inflammatory hepatocellular adenoma is inhibited by an anti-gp130 antibody that specifically neutralizes interleukin 11 signaling.
The Journal of biological chemistry 2012;287(17):13743-51.
2012: Francisco Garcia-Oscos; Shawn Hall; Ruben D Ramirez; Stefan Rose-John; Humberto Salgado; Feba Thomas; Jorge Bermeo; Santosh D'Mello; George E Farmer; Luis Charles Galindo; Marco Atzori
The stress-induced cytokine interleukin-6 decreases the inhibition/excitation ratio in the rat temporal cortex via trans-signaling.
Biological psychiatry 2012;71(7):574-82.
2012: Daniel Traum; Matthias Ernst; Stefan Rose-John; Jonathan Silver; Patricia Timothee; David F LaRosa
IL-10-induced gp130 expression in mouse mast cells permits IL-6 trans-signaling.
Journal of leukocyte biology 2012;91(3):427-35.
2012: Georg H Waetzig; Stefan Rose-John
Hitting a complex target: an update on interleukin-6 trans-signalling.
Expert opinion on therapeutic targets 2012;16(2):225-36.
2012: Alexander Krüttgen; Stefan Rose-John
Interleukin-6 in sepsis and capillary leakage syndrome.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2012;32(2):60-5.
2012: Harald Schuett; Dirk Seegert; Uwe J F Tietge; Johann von Felden; Georg H Waetzig; Kai C Wollert; Wijtske Annema; Udo Bavendiek; Dimitar Divchev; Anja Hillmer; Tibor Kempf; Maren Luchtefeld; René Oestreich; Stefan Rose-John; Bernhard Schieffer; Karsten Grote
Transsignaling of interleukin-6 crucially contributes to atherosclerosis in mice.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(2):281-90.
2012: Stefan Rose-John
IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6.
International journal of biological sciences 2012;8(9):1237-47.
2012: Athena Chalaris; Dirk Schmidt-Arras; Kosuke Yamamoto; Stefan Rose-John
Interleukin-6 trans-signaling and colonic cancer associated with inflammatory bowel disease.
Digestive diseases (Basel, Switzerland) 2012;30(5):492-9.
2012: Abdou ElSharawy; Michael Forster; James Brayer; Darren R Link; Jeff Olson; Stefan Rose-John; Philip Rosenstiel; Markus Schilhabel; Stefan Schreiber; Jason Warner; Andre Franke
Accurate variant detection across non-amplified and whole genome amplified DNA using targeted next generation sequencing.
BMC genomics 2012;13():500.
2012: Michael Schaab; Juergen Scheller; Joachim Thiery; Marcin Nowicki; Stefan Rose-John; Ulf Anderegg; Rolf Gebhardt; Henriette Kausch; Juergen Klammt; Juergen Kratzsch
Novel regulatory mechanisms for generation of the soluble leptin receptor: implications for leptin action.
PloS one 2012;7(4):e34787.
2012: Hanna Dams-Kozlowska; Katarzyna Gryska; D Izycki; Eliza Kwiatkowska-Borowczyk; Stefan Rose-John; Andrzej mackiewicz
A designer hyper interleukin 11 (H11) is a biologically active cytokine.
BMC biotechnology 2012;12():8.
2012: Cindy Meyer; Nicolas Piganeau; Stefan Rose-John; Tijana Zivkovic; Katja Eydeler; Joachim Grötzinger; Inken Lorenzen; Eileen Magbanua; Günter Mayer; Ulrich Hahn
Interleukin-6 receptor specific RNA aptamers for cargo delivery into target cells.
RNA biology 2012;9(1):67-80.
2011: Raja Atreya; Brigitte Bartsch; Kai M Hildner; Arthur Hoffman; Hermann Kessler; Ralf Kiesslich; Helmut Neumann; Tilman T Rau; Andreas D Rink; Stefan Rose-John; Jan Schmidt; Maximilian J Waldner; Michael Zimmer; Imke Atreya; Markus F Neurath
Antibodies against tumor necrosis factor (TNF) induce T-cell apoptosis in patients with inflammatory bowel diseases via TNF receptor 2 and intestinal CD14⁺ macrophages.
Gastroenterology 2011;141(6):2026-38.
2011: Daniel T Fisher; Sandra O Gollnick; Jason B Muhitch; Jessica Lynn Passanese; Elizabeth A Repasky; Stefan Rose-John; Joseph J Skitzki; Trupti D Vardam; Wan-Chao Wang; Emily L Weis; Lei Zhou; Michelle M Appenheimer; Heinz Baumann; Qing Chen; Mark W Dewhirst; Sharon S Evans
IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells.
The Journal of clinical investigation 2011;121(10):3846-59.
2011: Simon A Jones; Jürgen Scheller; Stefan Rose-John
Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling.
The Journal of clinical investigation 2011;121(9):3375-83.
2011: Jürgen Scheller; Athena Chalaris; Christoph Garbers; Stefan Rose-John
ADAM17: a molecular switch to control inflammation and tissue regeneration.
Trends in immunology 2011;32(8):380-7.
2011: Tanja Barkhausen; Athena Chalaris; Martina Dorsch; Christian Krettek; Annika Mueller-Heine; Stefan Rose-John; Philip Rosenstiel; Jürgen Scheller; Dirk Seegert; Thomas Tschernig; Martijn van Griensven; Ralf-Peter Vonberg; Georg H Waetzig
Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model.
Critical care medicine 2011;39(6):1407-13.
2011: Jan Suthaus; Nina Adam; Joachim Grötzinger; Jürgen Scheller; Stefan Rose-John
Viral Interleukin-6: Structure, pathophysiology and strategies of neutralization.
European journal of cell biology 2011;90(6-7):495-504.
2011: Athena Chalaris; Christoph Garbers; Björn Rabe; Stefan Rose-John; Jürgen Scheller
The soluble Interleukin 6 receptor: generation and role in inflammation and cancer.
European journal of cell biology 2011;90(6-7):484-94.
2011: Inken Lorenzen; Weifeng Shang; Markus Perbandt; Maxim V Petoukhov; Dmitri I Svergun; Georg H Waetzig; Stefan Rose-John; Rolf Hilgenfeld; Joachim Grötzinger
The structure of the unliganded extracellular domain of the interleukin-6 signal transducer gp130 in solution.
European journal of cell biology 2011;90(6-7):515-20.
2011: Gabriela Schiechl; Bernhard Bauer; Ivan J Fuss; Sven A Lang; Christian Moser; Petra Ruemmele; Stefan Rose-John; Markus F Neurath; Edward K Geissler; Hans-Jürgen Schlitt; Warren Strober; Stefan Fichtner-Feigl
Tumor development in murine ulcerative colitis depends on MyD88 signaling of colonic F4/80+CD11b(high)Gr1(low) macrophages.
The Journal of clinical investigation 2011;121(5):1692-708.
2011: Jürgen Scheller; Athena Chalaris; Dirk Schmidt-Arras; Stefan Rose-John
The pro- and anti-inflammatory properties of the cytokine interleukin-6.
Biochimica et biophysica acta 2011;1813(5):878-88.
2011: Yael Nechemia-Arbely; Anat Shriki; Ulrich Denz; Claudia Drucker; Jürgen Scheller; Jonathan Raub; Orit Pappo; Stefan Rose-John; Eithan Galun; Jonathan H Axelrod
Early hepatocyte DNA synthetic response posthepatectomy is modulated by IL-6 trans-signaling and PI3K/AKT activation.
Journal of hepatology 2011;54(5):922-9.
2011: Christoph Garbers; Nathalie Jänner; Athena Chalaris; Marcia L Moss; Doreen M Floss; Dörte Meyer; Friedrich Koch-Nolte; Stefan Rose-John; Jürgen Scheller
Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding.
The Journal of biological chemistry 2011;286(17):14804-11.
2011: Marina Lesina; Magdalena U Kurkowski; Katharina Ludes; Stefan Rose-John; Matthias Treiber; Günter Klöppel; Akihiko Yoshimura; Wolfgang Reindl; Bence Sipos; Shizuo Akira; Roland M Schmid; Hana Algül
Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer.
Cancer cell 2011;19(4):456-69.
2011: Harald Loppnow; Li Zhang; Michael Buerke; Michael Lautenschläger; Li Chen; Adrian Frister; Axel Schlitt; Tanja Luther; Nan Song; Britt Hofmann; Stefan Rose-John; Rolf-Edgar Silber; Ursula Müller-Werdan; Karl Werdan
Statins potently reduce the cytokine-mediated IL-6 release in SMC/MNC cocultures.
Journal of cellular and molecular medicine 2011;15(4):994-1004.
2011: Harald Loppnow; Michael Buerke; Karl Werdan; Stefan Rose-John
Contribution of vascular cell-derived cytokines to innate and inflammatory pathways in atherogenesis.
Journal of cellular and molecular medicine 2011;15(3):484-500.
2011: Sven Malchow; Wolfgang Thaiss; Nathalie Jänner; Georg H Waetzig; Jessica Gewiese-Rabsch; Christoph Garbers; Kosuke Yamamoto; Stefan Rose-John; Jürgen Scheller
Essential role of neutrophil mobilization in concanavalin A-induced hepatitis is based on classic IL-6 signaling but not on IL-6 trans-signaling.
Biochimica et biophysica acta 2011;1812(3):290-301.
2011: Claire J Greenhill; Stefan Rose-John; Rami Lissilaa; Walter Ferlin; Matthias Ernst; Paul J Hertzog; Ashley Mansell; Brendan J Jenkins
IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(2):1199-208.
2011: Chi-Wen Lo; Min-Wei Chen; Michael Hsiao; Shiuan Wang; Chi-An Chen; Sheng-Mou Hsiao; Jeng-Shou Chang; Tsung-Ching Lai; Stefan Rose-John; Min-Liang Kuo; Lin-Hung Wei
IL-6 trans-signaling in formation and progression of malignant ascites in ovarian cancer.
Cancer research 2011;71(2):424-34.
2011: Udo Conrad; Ingo Plagmann; Sven Malchow; Markus Sack; Doreen M Floss; Andrei A Kruglov; Sergei A Nedospasov; Stefan Rose-John; Jürgen Scheller
ELPylated anti-human TNF therapeutic single-domain antibodies for prevention of lethal septic shock.
Plant biotechnology journal 2011;9(1):22-31.
2010: Maximilian J Waldner; Stefan Wirtz; André Jefremow; Moritz Warntjen; Clemens Neufert; Raja Atreya; Christoph Becker; Benno Weigmann; Michael Vieth; Stefan Rose-John; Markus F Neurath
VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer.
The Journal of experimental medicine 2010;207(13):2855-68.
2010: Jason S Stumhofer; Elia D Tait; William J Quinn; Nancy Hosken; Björn Spudy; Radhika Goenka; Ceri Fielding; Aisling C O'Hara; Yi Chen; Michael L Jones; Christiaan J M Saris; Stefan Rose-John; Daniel J Cua; Simon A Jones; MM Elloso; Joachim Grötzinger; Michael P Cancro; Steven D Levin; Christopher A Hunter
A role for IL-27p28 as an antagonist of gp130-mediated signaling.
Nature immunology 2010;11(12):1119-26.
2010: Jessica Gewiese-Rabsch; Claudia Drucker; Sven Malchow; Jürgen Scheller; Stefan Rose-John
Role of IL-6 trans-signaling in CCl₄induced liver damage.
Biochimica et biophysica acta 2010;1802(11):1054-61.
2010: Michael Hammer; Bernd Echtenachter; Heike Weighardt; Katrin Jozefowski; Stefan Rose-John; Daniela N Männel; Bernhard Holzmann; Roland Lang
Increased inflammation and lethality of Dusp1-/- mice in polymicrobial peritonitis models.
Immunology 2010;131(3):395-404.
2010: Markus Bender; Sebastian Hofmann; David Stegner; Athena Chalaris; Michael Bösl; Attila Braun; Jürgen Scheller; Stefan Rose-John; Bernhard Nieswandt
Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases.
Blood 2010;116(17):3347-55.
2010: Shuk Pik Lam; John Luk; Kwan Man; Kevin Tak-Pan Ng; Cindy K Cheung; Stefan Rose-John; Chung-Mau Lo
Activation of interleukin-6-induced glycoprotein 130/signal transducer and activator of transcription 3 pathway in mesenchymal stem cells enhances hepatic differentiation, proliferation, and liver regeneration.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2010;16(10):1195-206.
2010: Nuria Rodriguez; Harald Dietrich; Ilona Mossbrugger; Gabriele Weintz; Jürgen Scheller; Michael Hammer; Leticia Quintanilla-Martinez; Stefan Rose-John; Thomas Miethke; Roland Lang
Increased inflammation and impaired resistance to Chlamydophila pneumoniae infection in Dusp1(-/-) mice: critical role of IL-6.
Journal of leukocyte biology 2010;88(3):579-87.
2010: Athena Chalaris; Nina Adam; Christian Sina; Philip Rosenstiel; Judith Lehmann-Koch; Peter Schirmacher; Dieter Hartmann; Joanna Cichy; Olga Gavrilova; Stefan Schreiber; Thomas Jostock; Vance Matthews; Robert Häsler; Christoph Becker; Markus F Neurath; Karina Reiss; Paul Saftig; Jürgen Scheller; Stefan Rose-John
Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice.
The Journal of experimental medicine 2010;207(8):1617-24.
2010: Jan Suthaus; Anna Tillmann; Inken Lorenzen; Elena Bulanova; Stefan Rose-John; Jürgen Scheller
Forced homo- and heterodimerization of all gp130-type receptor complexes leads to constitutive ligand-independent signaling and cytokine-independent growth.
Molecular biology of the cell 2010;21(15):2797-807.
2010: Eamon P McGreal; Philip L Davies; Wendy Powell; Stefan Rose-John; O Bradley Spiller; Iolo Doull; Simon A Jones; Sailesh Kotecha
Inactivation of IL-6 and soluble IL-6 receptor by neutrophil derived serine proteases in cystic fibrosis.
Biochimica et biophysica acta 2010;1802(7-8):649-58.
2010: Gareth W Jones; Rachel M McLoughlin; Victoria J Hammond; Clare R Parker; John D Williams; Raj Malhotra; Jürgen Scheller; Anwen Sian Williams; Stefan Rose-John; Nicholas Topley; Simon A Jones
Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(4):2130-9.
2010: S Matsumoto; Taeko Hara; Keiichi Mitsuyama; Mayuko Yamamoto; Osamu Tsuruta; Michio Sata; Jürgen Scheller; Stefan Rose-John; Shoichi Kado; Toshihiko Takada
Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(3):1543-51.
2010: Athena Chalaris; Jessica Gewiese; Krzysztof Paliga; Lina Fleig; Alex Schneede; Karsten Krieger; Stefan Rose-John; Jürgen Scheller
ADAM17-mediated shedding of the IL6R induces cleavage of the membrane stub by gamma-secretase.
Biochimica et biophysica acta 2010;1803(2):234-45.
2010: Claudia Drucker; Jessica Gewiese; Sven Malchow; Jürgen Scheller; Stefan Rose-John
Impact of interleukin-6 classic- and trans-signaling on liver damage and regeneration.
Journal of autoimmunity 2010;34(1):29-37.
2010: Georg H Waetzig; Athena Chalaris; Philip Rosenstiel; Jan Suthaus; Christin Holland; Nadja Karl; Lorena Vallés Uriarte; Andreas Till; Jürgen Scheller; Joachim Grötzinger; Stefan Schreiber; Stefan Rose-John; Dirk Seegert
N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130.
The Journal of biological chemistry 2010;285(3):1781-9.
2010: Doreen M Floss; Kai Schallau; Stefan Rose-John; Udo Conrad; Jürgen Scheller
Elastin-like polypeptides revolutionize recombinant protein expression and their biomedical application.
Trends in biotechnology 2010;28(1):37-45.
2010: A M Vahdat; Katrin S Reiners; V L Simhadri; D A Eichenauer; B Böll; A Chalaris; V R Simhadri; Katja Wiegmann; H-W Krell; Stefan Rose-John; Andreas Engert; Elke Pogge Von Strandmann; Hinrich P Hansen
TNF-alpha-converting enzyme (TACE/ADAM17)-dependent loss of CD30 induced by proteasome inhibition through reactive oxygen species.
Leukemia 2010;24(1):51-7.
2009: Marianna Hösel; Maria Quasdorff; Katja Wiegmann; Dennis Webb; Uta Zedler; Mathias Broxtermann; Raindy Tedjokusumo; Knud Esser; Silke Arzberger; Carsten J Kirschning; Anja Langenkamp; Christine Falk; Hildegard Büning; Stefan Rose-John; Ulrike Protzer
Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection.
Hepatology (Baltimore, Md.) 2009;50(6):1773-82.
2009: Christian Sina; Olga Gavrilova; Matti Förster; Andreas Till; Stefanie Derer; Friederike Hildebrand; Björn Raabe; Athena Chalaris; Jürgen Scheller; Ateequr Rehmann; Andre Franke; Stephan Ott; Robert Häsler; Susanna Nikolaus; Ulrich R Fölsch; Stefan Rose-John; Hui-Ping Jiang; Jun Li; Stefan Schreiber; Philip Rosenstiel
G protein-coupled receptor 43 is essential for neutrophil recruitment during intestinal inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(11):7514-22.
2009: Claudia Drucker; Björn Rabe; Athena Chalaris; Elsbeth Schulz; Jürgen Scheller; Stefan Rose-John
Interleukin-6 trans-signaling regulates glycogen consumption after D-galactosamine-induced liver damage.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2009;29(11):711-8.
2009: Manfred Andratsch; Norbert Mair; Cristina E Constantin; Nadja Scherbakov; Camilla Benetti; Serena Quarta; Christian Vogl; Claudia A Sailer; Nurcan Uceyler; Johannes Brockhaus; Rudolf Martini; Claudia Sommer; Hanns Ulrich Zeilhofer; Werner Muller; Rohini Kuner; John B Davis; Stefan Rose-John; Michaela Kress
A key role for gp130 expressed on peripheral sensory nerves in pathological pain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(43):13473-83.
2009: Christian Benedict; Jürgen Scheller; Stefan Rose-John; Jan Born; Lisa Marshall
Enhancing influence of intranasal interleukin-6 on slow-wave activity and memory consolidation during sleep.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009;23(10):3629-36.
2009: Ulrike May; Thomas Schiffelholz; Paul Christian Baier; James M Krueger; Stefan Rose-John; Jürgen Scheller
IL-6-trans-signalling increases rapid-eye-movement sleep in rats.
European journal of pharmacology 2009;613(1-3):141-5.
2009: Ingo Plagmann; Athena Chalaris; Andrei A Kruglov; Sergei Nedospasov; Philip Rosenstiel; Stefan Rose-John; Jürgen Scheller
Transglutaminase-catalyzed covalent multimerization of Camelidae anti-human TNF single domain antibodies improves neutralizing activity.
Journal of biotechnology 2009;142(2):170-8.
2009: Paul Christian Baier; Ulrike May; Jürgen Scheller; Stefan Rose-John; Thomas Schiffelholz
Impaired hippocampus-dependent and -independent learning in IL-6 deficient mice.
Behavioural brain research 2009;200(1):192-6.
2009: Nina Adam; Björn Rabe; Jan Suthaus; Joachim Grötzinger; Stefan Rose-John; Jürgen Scheller
Unraveling viral interleukin-6 binding to gp130 and activation of STAT-signaling pathways independently of the interleukin-6 receptor.
Journal of virology 2009;83(10):5117-26.
2009: Li Chen; Adrian Frister; Song Wang; Andreas Ludwig; Hagen Behr; Susanna Pippig; Beibei Li; Andreas Simm; Britt Hofmann; Claudia Pilowski; Susanne Koch; Michael Buerke; Stefan Rose-John; Karl Werdan; Harald Loppnow
Interaction of vascular smooth muscle cells and monocytes by soluble factors synergistically enhances IL-6 and MCP-1 production.
American journal of physiology. Heart and circulatory physiology 2009;296(4):H987-96.
2009: Sergei Grivennikov; Eliad Karin; Janos Terzic; Daniel Mucida; Guann-Yi Yu; Sivakumar Vallabhapurapu; Jürgen Scheller; Stefan Rose-John; Hilde Cheroutre; Lars Eckmann; Michael Karin
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer.
Cancer cell 2009;15(2):103-13.
2009: Stefan Rose-John; Keiichi Mitsuyama; Satoshi Matsumoto; Wolfgang M Thaiss; Jürgen Scheller
Interleukin-6 trans-signaling and colonic cancer associated with inflammatory bowel disease.
Current pharmaceutical design 2009;15(18):2095-103.
2009: Mari A Nowell; Anwen Sian Williams; Sarah A Carty; Jürgen Scheller; Anthony J Hayes; Gareth W Jones; Peter J Richards; Simon Slinn; Matthias Ernst; Brendan J Jenkins; Nicholas Topley; Stefan Rose-John; Simon A Jones
Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(1):613-22.
2009: Omedul Islam; Xiandi Gong; Stefan Rose-John; Klaus Heese
Interleukin-6 and neural stem cells: more than gliogenesis.
Molecular biology of the cell 2009;20(1):188-99.
2008: Ralf A Linker; Fred Lühder; Karl-Josef Kallen; De-Hyung Lee; Britta Engelhardt; Stefan Rose-John; Ralf Gold
IL-6 transsignalling modulates the early effector phase of EAE and targets the blood-brain barrier.
Journal of neuroimmunology 2008;205(1-2):64-72.
2008: Stephanie Tenhumberg; Georg H Waetzig; Athena Chalaris; Björn Rabe; Dirk Seegert; Jürgen Scheller; Stefan Rose-John; Joachim Grötzinger
Structure-guided optimization of the interleukin-6 trans-signaling antagonist sgp130.
The Journal of biological chemistry 2008;283(40):27200-7.
2008: Michele A West; Alan R Prescott; Kui Ming Chan; Zhongjun Zhou; Stefan Rose-John; Jürgen Scheller; Colin Watts
TLR ligand-induced podosome disassembly in dendritic cells is ADAM17 dependent.
The Journal of cell biology 2008;182(5):993-1005.
2008: Benno Weigmann; Hans A Lehr; George Yancopoulos; David Valenzuela; Andrew Murphy; Sean Stevens; Jan Schmidt; Peter Galle; Stefan Rose-John; Markus F Neurath
The transcription factor NFATc2 controls IL-6-dependent T cell activation in experimental colitis.
The Journal of experimental medicine 2008;205(9):2099-110.
2008: Jonas Mudter; Lioubov Amoussina; Mirjam Schenk; Jingling Yu; Anne Brüstle; Benno Weigmann; Raja Atreya; Stefan Wirtz; Christoph Becker; Arthur Hoffman; Imke Atreya; Stefan Biesterfeld; Peter R Galle; Hans-Anton Lehr; Stefan Rose-John; Christoph Mueller; Michael Lohoff; Markus F Neurath
The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6.
The Journal of clinical investigation 2008;118(7):2415-26.
2008: Yael Nechemia-Arbely; Daniel Barkan; Galina Pizov; Anat Shriki; Stefan Rose-John; Eithan Galun; Jonathan H Axelrod
IL-6/IL-6R axis plays a critical role in acute kidney injury.
Journal of the American Society of Nephrology : JASN 2008;19(6):1106-15.
2008: Mariapaola Marino; Flavia Scuderi; Carlo Provenzano; Jürgen Scheller; Stefan Rose-John; Emanuela Bartoccioni
IL-6 regulates MCP-1, ICAM-1 and IL-6 expression in human myoblasts.
Journal of neuroimmunology 2008;196(1-2):41-8.
2008: Enge Sudarman; Mariela Bollati-Fogolín; Martin Hafner; Werner Muller; Jürgen Scheller; Stefan Rose-John; Jutta Eichler
Synthetic mimetics of the gp130 binding site for viral interleukin-6 as inhibitors of the vIL-6-gp130 interaction.
Chemical biology & drug design 2008;71(5):494-500.
2008: Francesca Walker; Hui-Hua Zhang; Vance Matthews; Janet Weinstock; Edouard C Nice; Matthias Ernst; Stefan Rose-John; Antony W Burgess
IL6/sIL6R complex contributes to emergency granulopoietic responses in G-CSF- and GM-CSF-deficient mice.
Blood 2008;111(8):3978-85.
2008: Anna Benrick; Pernilla Jirholt; Ingrid Wernstedt; Maria Gustafsson; Jürgen Scheller; Anna-Lena Eriksson; Jan Borén; Thomas Hedner; Claes Ohlsson; Torleif Härd; Stefan Rose-John; John-Olov Jansson
A non-conservative polymorphism in the IL-6 signal transducer (IL6ST)/gp130 is associated with myocardial infarction in a hypertensive population.
Regulatory peptides 2008;146(1-3):189-96.
2008: Björn Rabe; Athena Chalaris; Ulrike May; Georg H Waetzig; Dirk Seegert; Anwen Sian Williams; Simon A Jones; Stefan Rose-John; Jürgen Scheller
Transgenic blockade of interleukin 6 transsignaling abrogates inflammation.
Blood 2008;111(3):1021-8.
2008: Thomas Hieronymus; David Ruau; Julia Ober-Blöbaum; Jea-Hyun Baek; Alexandra Rolletschek; Stefan Rose-John; Anna M Wobus; Albrecht M Müller; Martin Zenke
The transcription factor repertoire of Flt3+ hematopoietic stem cells.
Cells, tissues, organs 2008;188(1-2):103-15.
2007: Manuel Koch; Ulrike May; Stefanie Kuhns; Hauke Drechsler; Nina Adam; Kirsten Hattermann; Stefan Wirtz; Stefan Rose-John; Jürgen Scheller
Interleukin 27 induces differentiation of neural C6-precursor cells into astrocytes.
Biochemical and biophysical research communications 2007;364(3):483-7.
2007: Michelle M Appenheimer; Rachael A Girard; Qing Chen; Wan-Chao Wang; Katherine C Bankert; Joy Hardison; Mark D Bain; Frank Ridgley; Edward J Sarcione; Sandra Buitrago; Sonja Kothlow; Bernd Kaspers; Jacques Robert; Stefan Rose-John; Heinz Baumann; Sharon S Evans
Conservation of IL-6 trans-signaling mechanisms controlling L-selectin adhesion by fever-range thermal stress.
European journal of immunology 2007;37(10):2856-67.
2007: Athena Chalaris; Björn Rabe; Krzysztof Paliga; Hans Lange; Tamas Laskay; Ceri Fielding; Simon A Jones; Stefan Rose-John; Jürgen Scheller
Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils.
Blood 2007;110(6):1748-55.
2007: Sabine Dominitzki; Massimo C Fantini; Clemens Neufert; Alexei Nikolaev; Peter R Galle; Jürgen Scheller; Giovanni Monteleone; Stefan Rose-John; Markus F Neurath; Christoph Becker
Cutting edge: trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cells.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(4):2041-5.
2007: Barbara Coles; Ceri Fielding; Stefan Rose-John; Jürgen Scheller; Simon A Jones; Valerie B O'Donnell
Classic interleukin-6 receptor signaling and interleukin-6 trans-signaling differentially control angiotensin II-dependent hypertension, cardiac signal transducer and activator of transcription-3 activation, and vascular hypertrophy in vivo.
The American journal of pathology 2007;171(1):315-25.
2007: Susetta Finotto; Tatjana Eigenbrod; Roman Karwot; Ildiko Boross; Aysefa Doganci; Hiroaki Ito; Norihiro Nishimoto; Kazuyuki Yoshizaki; Tadamitsu Kishimoto; Stefan Rose-John; Peter R Galle; Markus F Neurath
Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells.
International immunology 2007;19(6):685-93.
2007: Stefan Rose-John; Georg H Waetzig; Jürgen Scheller; Joachim Grötzinger; Dirk Seegert
The IL-6/sIL-6R complex as a novel target for therapeutic approaches.
Expert opinion on therapeutic targets 2007;11(5):613-24.
2007: Souvik Chattopadhyay; Erin Tracy; Ping Liang; Olivier Robledo; Stefan Rose-John; Heinz Baumann
Interleukin-31 and oncostatin-M mediate distinct signaling reactions and response patterns in lung epithelial cells.
The Journal of biological chemistry 2007;282(5):3014-26.
2007: George C T Yeoh; Matthias Ernst; Stefan Rose-John; Barbara Akhurst; Christine Payne; Sarah Long; Warren Alexander; Ben A Croker; Dianne Grail; Vance B Matthews
Opposing roles of gp130-mediated STAT-3 and ERK-1/ 2 signaling in liver progenitor cell migration and proliferation.
Hepatology (Baltimore, Md.) 2007;45(2):486-94.
2007: Stefan Rose-John; Heidi Schooltink
Cytokines are a therapeutic target for the prevention of inflammation-induced cancers.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 2007;174():57-66.
2007: Dennis A Eichenauer; Vijaya Lakshmi Simhadri; Elke Pogge Von Strandmann; Andreas Ludwig; Vance Matthews; Katrin S Reiners; Bastian Von Tresckow; Paul Saftig; Stefan Rose-John; Andreas Engert; Hinrich P Hansen
ADAM10 inhibition of human CD30 shedding increases specificity of targeted immunotherapy in vitro.
Cancer research 2007;67(1):332-8.
2006: Qing Chen; Daniel T Fisher; Kristen A Clancy; Jean-Marc Gauguet; Wan-Chao Wang; Emily Unger; Stefan Rose-John; Ulrich H von Andrian; Heinz Baumann; Sharon S Evans
Fever-range thermal stress promotes lymphocyte trafficking across high endothelial venules via an interleukin 6 trans-signaling mechanism.
Nature immunology 2006;7(12):1299-308.
2006: Keiichi Mitsuyama; Michio Sata; Stefan Rose-John
Interleukin-6 trans-signaling in inflammatory bowel disease.
Cytokine & growth factor reviews 2006;17(6):451-61.
2006: Jürgen Scheller; Stefan Rose-John
Interleukin-6 and its receptor: from bench to bedside.
Medical microbiology and immunology 2006;195(4):173-83.
2006: Stoyan Dimitrov; Tanja Lange; Christian Benedict; Mari A Nowell; Simon A Jones; Jürgen Scheller; Stefan Rose-John; Jan Born
Sleep enhances IL-6 trans-signaling in humans.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(12):2174-6.
2006: Meng Lin; Stefan Rose-John; Joachim Grötzinger; Udo Conrad; Jürgen Scheller
Functional expression of a biologically active fragment of soluble gp130 as an ELP-fusion protein in transgenic plants: purification via inverse transition cycling.
The Biochemical journal 2006;398(3):577-83.
2006: Oliver Hecht; Andrew J Dingley; Andreas Schwanter; Suat Ozbek; Stefan Rose-John; Joachim Grötzinger
The solution structure of the membrane-proximal cytokine receptor domain of the human interleukin-6 receptor.
Biological chemistry 2006;387(9):1255-9.
2006: Marina Kovaleva; Ingo Bussmeyer; Björn Rabe; Joachim Grötzinger; Enge Sudarman; Jutta Eichler; Udo Conrad; Stefan Rose-John; Jürgen Scheller
Abrogation of viral interleukin-6 (vIL-6)-induced signaling by intracellular retention and neutralization of vIL-6 with an anti-vIL-6 single-chain antibody selected by phage display.
Journal of virology 2006;80(17):8510-20.
2006: Keiichi Mitsuyama; Satoshi Matsumoto; Stefan Rose-John; Asuka Suzuki; T Hara; Nobuo Tomiyasu; Kazuyo Handa; Osamu Tsuruta; H Funabashi; Jürgen Scheller; Atsushi Toyonaga; Michio Sata
STAT3 activation via interleukin 6 trans-signalling contributes to ileitis in SAMP1/Yit mice.
Gut 2006;55(9):1263-9.
2006: Stephanie Tenhumberg; Björn Schuster; Lixin Zhu; Marina Kovaleva; Jürgen Scheller; Karl-Josef Kallen; Stefan Rose-John
gp130 dimerization in the absence of ligand: preformed cytokine receptor complexes.
Biochemical and biophysical research communications 2006;346(3):649-57.
2006: Stefan Rose-John; Jürgen Scheller; Greg Elson; Simon A Jones
Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer.
Journal of leukocyte biology 2006;80(2):227-36.
2006: Christiane Stuhlmann-Laeisz; Sigrid Lang; Athena Chalaris; Paliga Krzysztof; Sudarman Enge; Jutta Eichler; Ursula Klingmüller; Michael Samuel; Matthias Ernst; Stefan Rose-John; Jürgen Scheller
Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine-independent growth, and blockade of differentiation of embryonic stem cells.
Molecular biology of the cell 2006;17(7):2986-95.
2006: Peter J Richards; Mari A Nowell; Sankichi Horiuchi; Rachel M McLoughlin; Ceri Fielding; Sandra Grau; Naoki Yamamoto; Michael Ehrmann; Stefan Rose-John; Anwen Sian Williams; Nicholas Topley; Simon A Jones
Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis.
Arthritis and rheumatism 2006;54(5):1662-72.
2006: Jürgen Scheller; N Ohnesorge; Stefan Rose-John
Interleukin-6 trans-signalling in chronic inflammation and cancer.
Scandinavian journal of immunology 2006;63(5):321-9.
2006: Matthew J Watt; Nicolas Dzamko; Walter G Thomas; Stefan Rose-John; Matthias Ernst; David Carling; Bruce E Kemp; Mark A Febbraio; Gregory R Steinberg
CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK.
Nature medicine 2006;12(5):541-8.
2006: David Campard; Marc Vasse; Stefan Rose-John; Florent Poyer; Marek Lamacz; Jean-Pierre Vannier
Multilevel regulation of IL-6R by IL-6-sIL-6R fusion protein according to the primitiveness of peripheral blood-derived CD133+ cells.
Stem cells (Dayton, Ohio) 2006;24(5):1302-14.
2006: Hans-Heinrich Oberg; Daniela Wesch; Sandra Grüssel; Stefan Rose-John; Dieter Kabelitz
Differential expression of CD126 and CD130 mediates different STAT-3 phosphorylation in CD4+CD25- and CD25high regulatory T cells.
International immunology 2006;18(4):555-63.
2005: Thorsten Maretzky; Marc Schulte; Andreas Ludwig; Stefan Rose-John; Carl Blobel; Dieter Hartmann; Peter Altevogt; Paul Saftig; Karina Reiss
L1 is sequentially processed by two differently activated metalloproteases and presenilin/gamma-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowth.
Molecular and cellular biology 2005;25(20):9040-53.
2005: Ceri Fielding; Rachel M McLoughlin; Chantal S Colmont; Marina Kovaleva; Dean A Harris; Stefan Rose-John; Nicholas Topley; Simon A Jones
Viral IL-6 blocks neutrophil infiltration during acute inflammation.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(6):4024-9.
2005: Simon A Jones; Peter J Richards; Jürgen Scheller; Stefan Rose-John
IL-6 transsignaling: the in vivo consequences.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2005;25(5):241-53.
2005: Christian Klein; Torsten Wüstefeld; Ulrike Assmus; Tania Roskams; Stefan Rose-John; Michael Müller; Michael P Manns; Mattias Ernst; Christian Trautwein
The IL-6-gp130-STAT3 pathway in hepatocytes triggers liver protection in T cell-mediated liver injury.
The Journal of clinical investigation 2005;115(4):860-9.
2005: Heidi Schooltink; Stefan Rose-John
Designing cytokine variants by phage-display.
Combinatorial chemistry & high throughput screening 2005;8(2):173-9.
2005: Thomas Hieronymus; Tatjana C Gust; Ralf D Kirsch; Thorsten Jorgas; Gitta Blendinger; Mykola Goncharenko; Kamilla Supplitt; Stefan Rose-John; Albrecht M Müller; Martin Zenke
Progressive and controlled development of mouse dendritic cells from Flt3+CD11b+ progenitors in vitro.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(5):2552-62.
2005: Andreas Schroers; Oliver Hecht; Karl-Josef Kallen; Michael Pachta; Stefan Rose-John; Joachim Grötzinger
Dynamics of the gp130 cytokine complex: a model for assembly on the cellular membrane.
Protein science : a publication of the Protein Society 2005;14(3):783-90.
2005: Aysefa Doganci; Tatjana Eigenbrod; Norbert Krug; George T De Sanctis; Michael Hausding; Veit J Erpenbeck; El-Bdaoui Haddad; Hans-Anton Lehr; Edgar Schmitt; Tobias Bopp; Karl-Josef Kallen; Udo Herz; Steffen Schmitt; Cornelia Luft; Oliver Hecht; Jens Hohlfeld; Hiroaki Ito; Norihiro Nishimoto; Kazuyuki Yoshizaki; Tadamitsu Kishimoto; Stefan Rose-John; Harald Renz; Markus F Neurath; Peter R Galle; Susetta Finotto
The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo.
The Journal of clinical investigation 2005;115(2):313-25.
2005: Christoph Becker; Massimo C Fantini; Stefan Wirtz; Alexei Nikolaev; Hans-Anton Lehr; Peter R Galle; Stefan Rose-John; Markus F Neurath
IL-6 signaling promotes tumor growth in colorectal cancer.
Cell cycle (Georgetown, Tex.) 2005;4(2):217-20.
2005: Jürgen Scheller; Björn Schuster; Christoph Hölscher; Takayuki Yoshimoto; Stefan Rose-John
No inhibition of IL-27 signaling by soluble gp130.
Biochemical and biophysical research communications 2005;326(4):724-8.
2005: Georg H Waetzig; Philip Rosenstiel; Alexander Arlt; Andreas Till; Karen Bräutigam; Heiner Schäfer; Stefan Rose-John; Dirk Seegert; Stefan Schreiber
Soluble tumor necrosis factor (TNF) receptor-1 induces apoptosis via reverse TNF signaling and autocrine transforming growth factor-beta1.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(1):91-3.
2004: Mariam Klouche; Giuseppe Carruba; Luigi Castagnetta; Stefan Rose-John
Virokines in the pathogenesis of cancer: focus on human herpesvirus 8.
Annals of the New York Academy of Sciences 2004;1028():329-39.
2004: S John Curnow; Dagmar Scheel-Toellner; Will Jenkinson; Karim Raza; Omar M Durrani; Jeff M Faint; Saaeha Rauz; Kaska Wloka; Darrell Pilling; Stefan Rose-John; Christopher D Buckley; Philip I Murray; Mike Salmon
Inhibition of T cell apoptosis in the aqueous humor of patients with uveitis by IL-6/soluble IL-6 receptor trans-signaling.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(8):5290-7.
2004: Christoph Becker; Massimo C Fantini; Christoph Schramm; Hans-Anton Lehr; Stefan Wirtz; Alexei Nikolaev; Jürgen Burg; Susanne Strand; Ralf Kiesslich; Samuel Huber; Hiroaki Ito; Norihiro Nishimoto; Kazuyuki Yoshizaki; Tadamitsu Kishimoto; Peter R Galle; Manfred Blessing; Stefan Rose-John; Markus F Neurath
TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling.
Immunity 2004;21(4):491-501.
2004: Vadim Budagian; Elena Bulanova; Zane Orinska; Andreas Ludwig; Stefan Rose-John; Paul Saftig; Ernest C Borden; Silvia Bulfone-Paus
Natural soluble interleukin-15Ralpha is generated by cleavage that involves the tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17).
The Journal of biological chemistry 2004;279(39):40368-75.
2004: Vance B Matthews; Stefan Rose-John; George C T Yeoh
Genetic manipulations utilizing albumin and alpha-fetoprotein promoter/enhancers affect both hepatocytes and oval cells.
Hepatology (Baltimore, Md.) 2004;40(3):759; author reply 760.
2004: Pia März; Alphonse Probst; Sigrid Lang; Martine Schwager; Stefan Rose-John; Uwe Otten; Suat Ozbek
Ataxin-10, the spinocerebellar ataxia type 10 neurodegenerative disorder protein, is essential for survival of cerebellar neurons.
The Journal of biological chemistry 2004;279(34):35542-50.
2004: Jürgen Scheller; Marina Kovaleva; Björn Rabe; Jutta Eichler; Karl-Josef Kallen; Stefan Rose-John
Development of a monoclonal antibody-based enzyme-linked immunoabsorbent assay for the binding of gp130 to the IL-6/IL-6R complex and its competitive inhibition.
Journal of immunological methods 2004;291(1-2):93-100.
2004: Andreas Schwantner; Andrew J Dingley; Suat Ozbek; Oliver Hecht; Stefan Rose-John; Joachim Grötzinger
1H, 15N and 13C backbone assignment of the carboxyl terminal domain of the cytokine binding module of the interleukin-6 receptor.
Journal of biomolecular NMR 2004;29(3):407-8.
2004: Xu-Ping Wang; Michael Schunck; Karl-Josef Kallen; Claudia Neumann; Christian Trautwein; Stefan Rose-John; Ehrhardt Proksch
The interleukin-6 cytokine system regulates epidermal permeability barrier homeostasis.
The Journal of investigative dermatology 2004;123(1):124-31.
2004: Soeren Abel; Christian Hundhausen; Rolf Mentlein; Alexander Schulte; Theo A Berkhout; Neil Broadway; Dieter Hartmann; Radislav Sedlacek; Sebastian Dietrich; Barbara Muetze; Björn Schuster; Karl-Josef Kallen; Paul Saftig; Stefan Rose-John; Andreas Ludwig
The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(10):6362-72.
2004: Andreas Schwantner; Andrew J Dingley; Suat Ozbek; Stefan Rose-John; Joachim Grötzinger
Direct determination of the interleukin-6 binding epitope of the interleukin-6 receptor by NMR spectroscopy.
The Journal of biological chemistry 2004;279(1):571-6.
2004: Rohan K Humphrey; Gillian M Beattie; Ana D Lopez; Nathan Bucay; Charles C King; Meri T Firpo; Stefan Rose-John; Alberto Hayek
Maintenance of pluripotency in human embryonic stem cells is STAT3 independent.
Stem cells (Dayton, Ohio) 2004;22(4):522-30.
2004: Stefan Rose-John; Markus F Neurath
IL-6 trans-signaling: the heat is on.
Immunity 2004;20(1):2-4.
2003: Martin Fuchs; Andres Hilfiker; Karol Kaminski; Denise Hilfiker-Kleiner; Zeynep Guener; Gunnar Klein; Edith Podewski; Bernhard Schieffer; Stefan Rose-John; Helmut Drexler
Role of interleukin-6 for LV remodeling and survival after experimental myocardial infarction.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(14):2118-20.
2003: Vance Matthews; Björn Schuster; Stefan Schütze; Ingo Bussmeyer; Andreas Ludwig; Christian Hundhausen; Thorsten Sadowski; Paul Saftig; Dieter Hartmann; Karl-Josef Kallen; Stefan Rose-John
Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE).
The Journal of biological chemistry 2003;278(40):38829-39.
2003: Mari A Nowell; Peter J Richards; Sankichi Horiuchi; Naoki Yamamoto; Stefan Rose-John; Nicholas Topley; Anwen Sian Williams; Simon A Jones
Soluble IL-6 receptor governs IL-6 activity in experimental arthritis: blockade of arthritis severity by soluble glycoprotein 130.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(6):3202-9.
2003: Christian Hundhausen; Dominika Misztela; Theo A Berkhout; Neil Broadway; Paul Saftig; Karina Reiss; Dieter Hartmann; Falk Fahrenholz; Rolf Postina; Vance Matthews; Karl-Josef Kallen; Stefan Rose-John; Andreas Ludwig
The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion.
Blood 2003;102(4):1186-95.
2003: Rachel M McLoughlin; Janusz Witowski; Rachel L Robson; Thomas S Wilkinson; Suzanne M Hurst; Anwen Sian Williams; John D Williams; Stefan Rose-John; Simon A Jones; Nicholas Topley
Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation.
The Journal of clinical investigation 2003;112(4):598-607.
2003: Dorthe Aasland; Björn Schuster; Joachim Grötzinger; Stefan Rose-John; Karl-Josef Kallen
Analysis of the leukemia inhibitory factor receptor functional domains by chimeric receptors and cytokines.
Biochemistry 2003;42(18):5244-52.
2003: Stefan Rose-John; Heidi Schooltink
CDP-870. Celltech/Pfizer.
Current opinion in investigational drugs (London, England : 2000) 2003;4(5):588-92.
2003: Christine Hacker; Ralf D Kirsch; Xin-Sheng Ju; Thomas Hieronymus; Tatjana C Gust; Christiane Kuhl; Thorsten Jorgas; Steffen M Kurz; Stefan Rose-John; Yoshifumi Yokota; Martin Zenke
Transcriptional profiling identifies Id2 function in dendritic cell development.
Nature immunology 2003;4(4):380-6.
2003: Björn Schuster; Marina Kovaleva; Yi Sun; Petra Regenhard; Vance Matthews; Joachim Grötzinger; Stefan Rose-John; Karl-Josef Kallen
Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF.
The Journal of biological chemistry 2003;278(11):9528-35.
2003: Björn Schuster; Werner Meinert; Stefan Rose-John; Karl-Josef Kallen
The human interleukin-6 (IL-6) receptor exists as a preformed dimer in the plasma membrane.
FEBS letters 2003;538(1-3):113-6.
2003: Xin-Sheng Ju; Christine Hacker; Jaime Madruga; Steffen M Kurz; Siegne Knespel; Gitta Blendinger; Stefan Rose-John; Zenke Martin
Towards determining the differentiation program of antigen-presenting dendritic cells by transcriptional profiling.
European journal of cell biology 2003;82(2):75-86.
2003: Stefan Rose-John
Interleukin-6 biology is coordinated by membrane bound and soluble receptors.
Acta biochimica Polonica 2003;50(3):603-11.
2002: Steve Lacroix; Leon Chang; Stefan Rose-John; Mark H Tuszynski
Delivery of hyper-interleukin-6 to the injured spinal cord increases neutrophil and macrophage infiltration and inhibits axonal growth.
The Journal of comparative neurology 2002;454(3):213-28.
2002: Simon A Jones; Stefan Rose-John
The role of soluble receptors in cytokine biology: the agonistic properties of the sIL-6R/IL-6 complex.
Biochimica et biophysica acta 2002;1592(3):251-63.
2002: Stefan Rose-John
Cytokines come of age.
Biochimica et biophysica acta 2002;1592(3):213-4.
2002: Hanns F Löhr; Sabine Pingel; Wulf O Böcher; H Bernhard; Sabine Herzog-Hauff; Stefan Rose-John; Peter R Galle
Reduced virus specific T helper cell induction by autologous dendritic cells in patients with chronic hepatitis B - restoration by exogenous interleukin-12.
Clinical and experimental immunology 2002;130(1):107-14.
2002: Stefan Rose-John
GP130 stimulation and the maintenance of stem cells.
Trends in biotechnology 2002;20(10):417-9.
2002: Yi Sun; Pia März; Uwe Otten; Jiguang Ge; Stefan Rose-John
The effect of gp130 stimulation on glutamate-induced excitotoxicity in primary hippocampal neurons.
Biochemical and biophysical research communications 2002;295(2):532-9.
2002: Pia März; Suat Ozbek; Martina Fischer; Nicole Voltz; Uwe Otten; Stefan Rose-John
Differential response of neuronal cells to a fusion protein of ciliary neurotrophic factor/soluble CNTF-receptor and leukemia inhibitory factor.
European journal of biochemistry / FEBS 2002;269(12):3023-31.
2002: Mariam Klouche; Norbert Brockmeyer; Cornelius Knabbe; Stefan Rose-John
Human herpesvirus 8-derived viral IL-6 induces PTX3 expression in Kaposi's sarcoma cells.
AIDS (London, England) 2002;16(8):F9-18.
2002: Heidi Schooltink; Stefan Rose-John
Cytokines as therapeutic drugs.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2002;22(5):505-16.
2002: Dorthe Aasland; Birgit Oppmann; Joachim Grötzinger; Stefan Rose-John; Karl-Josef Kallen
The upper cytokine-binding module and the Ig-like domain of the leukaemia inhibitory factor (LIF) receptor are sufficient for a functional LIF receptor complex.
Journal of molecular biology 2002;315(4):637-46.
2002: Sowmya Viswanathan; Tania Benatar; Stefan Rose-John; Doug A Lauffenburger; Peter W Zandstra
Ligand/receptor signaling threshold (LIST) model accounts for gp130-mediated embryonic stem cell self-renewal responses to LIF and HIL-6.
Stem cells (Dayton, Ohio) 2002;20(2):119-38.
2001: Wulf O Böcher; Benjamin Dekel; W Schwerin; Michael Geissler; S Hoffmann; A Rohwer; Fabian D Arditti; A Cooper; H Bernhard; A Berrebi; Stefan Rose-John; Y Shaul; Peter R Galle; Hanns F Löhr; Yair Reisner
Induction of strong hepatitis B virus (HBV) specific T helper cell and cytotoxic T lymphocyte responses by therapeutic vaccination in the trimera mouse model of chronic HBV infection.
European journal of immunology 2001;31(7):2071-9.
2001: Suzanne M Hurst; Thomas S Wilkinson; Rachel M McLoughlin; S Jones; Sankichi Horiuchi; Naoki Yamamoto; Stefan Rose-John; Gerald M Fuller; Nicholas Topley; Simon A Jones
Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation.
Immunity 2001;14(6):705-14.
2001: D Heinz; M Peters; Reinhild Prange; Guido Gerken; Stefan Rose-John
Possible role of human interleukin-6 and soluble interleukin-6 receptor in hepatitis B virus infection.
Journal of viral hepatitis 2001;8(3):186-93.
2001: A Mann; K Breuhahn; Peter Schirmacher; A Wilhelmi; C Beyer; A Rosenau; Suat Ozbek; Stefan Rose-John; Manfred Blessing
Up- and down-regulation of granulocyte/macrophage-colony stimulating factor activity in murine skin increase susceptibility to skin carcinogenesis by independent mechanisms.
Cancer research 2001;61(5):2311-9.
2001: Suat Ozbek; M Peters; K Breuhahn; A Mann; Manfred Blessing; Martina Fischer; Peter Schirmacher; A Mackiewicz; Stefan Rose-John
The designer cytokine hyper-IL-6 mediates growth inhibition and GM-CSF-dependent rejection of B16 melanoma cells.
Oncogene 2001;20(8):972-9.
2001: K Althoff; Jürgen Müllberg; Dorthe Aasland; Nicole Voltz; Karl-Josef Kallen; Joachim Grötzinger; Stefan Rose-John
Recognition sequences and structural elements contribute to shedding susceptibility of membrane proteins.
The Biochemical journal 2001;353(Pt 3):663-72.
2001: M Peters; Fian K Solem; J Goldschmidt; Peter Schirmacher; Stefan Rose-John
Interleukin-6 and the soluble interleukin-6 receptor induce stem cell factor and Flt-3L expression in vivo and in vitro.
Experimental hematology 2001;29(2):146-55.
2001: Stefan Rose-John
Coordination of interleukin-6 biology by membrane bound and soluble receptors.
Advances in experimental medicine and biology 2001;495():145-51.
2001: Uwe Otten; Pia März; Klaus Heese; Christoph Hock; D Kunz; Stefan Rose-John
Signals regulating neurotrophin expression in glial cells.
Progress in brain research 2001;132():545-54.
2001: Thomas Jostock; Jürgen Müllberg; Suat Ozbek; Raja Atreya; G Blinn; Nicole Voltz; Martina Fischer; Markus F Neurath; Stefan Rose-John
Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses.
European journal of biochemistry / FEBS 2001;268(1):160-7.
2000: M Peters; G Blinn; Thomas Jostock; Peter Schirmacher; Karl-Hermann Meyer zum Büschenfelde; Peter R Galle; Stefan Rose-John
Combined interleukin 6 and soluble interleukin 6 receptor accelerates murine liver regeneration.
Gastroenterology 2000;119(6):1663-71.
2000: Karl-Josef Kallen; Joachim Grötzinger; Stefan Rose-John
New perspectives on the design of cytokines and growth factors.
Trends in biotechnology 2000;18(11):455-61.
2000: S H Hoischen; Petra Vollmer; Pia März; Suat Ozbek; K S Götze; Christian Peschel; Thomas Jostock; T Geib; Jürgen Müllberg; S Mechtersheimer; Martina Fischer; Joachim Grötzinger; Peter R Galle; Stefan Rose-John
Human herpes virus 8 interleukin-6 homologue triggers gp130 on neuronal and hematopoietic cells.
European journal of biochemistry / FEBS 2000;267(12):3604-12.
2000: Raja Atreya; Jonas Mudter; Susetta Finotto; Jürgen Müllberg; Thomas Jostock; Stefan Wirtz; Michael Schütz; Brigitte Bartsch; Martin H Holtmann; Christoph Becker; Dennis Strand; Joachim Czaja; Joerg F Schlaak; Hans-Anton Lehr; Frank Autschbach; G Schürmann; Norihiro Nishimoto; Kazuyuki Yoshizaki; Hiroaki Ito; Tadamitsu Kishimoto; Peter R Galle; Stefan Rose-John; Markus F Neurath
Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo.
Nature medicine 2000;6(5):583-8.
2000: K Althoff; P Reddy; Nicole Voltz; Stefan Rose-John; Jürgen Müllberg
Shedding of interleukin-6 receptor and tumor necrosis factor alpha. Contribution of the stalk sequence to the cleavage pattern of transmembrane proteins.
European journal of biochemistry / FEBS 2000;267(9):2624-31.
2000: Jürgen Müllberg; T Geib; Thomas Jostock; S H Hoischen; Petra Vollmer; Nicole Voltz; D Heinz; Peter R Galle; Mariam Klouche; Stefan Rose-John
IL-6 receptor independent stimulation of human gp130 by viral IL-6.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(9):4672-7.
2000: Mariam Klouche; Stefan Rose-John; Walther Schmiedt; Sucharit Bhakdi
Enzymatically degraded, nonoxidized LDL induces human vascular smooth muscle cell activation, foam cell transformation, and proliferation.
Circulation 2000;101(15):1799-805.
2000: H Bernhard; M Lohmann; WY Batten; Jochen Metzger; Hanns F Löhr; C Peschel; K M zum Büschenfelde; Stefan Rose-John
The gp130-stimulating designer cytokine hyper-IL-6 promotes the expansion of human hematopoietic progenitor cells capable to differentiate into functional dendritic cells.
Experimental hematology 2000;28(4):365-72.
2000: Jürgen Müllberg; K Althoff; Thomas Jostock; Stefan Rose-John
The importance of shedding of membrane proteins for cytokine biology.
European cytokine network 2000;11(1):27-38.
2000: Uwe Otten; Pia März; Klaus Heese; Christoph Hock; D Kunz; Stefan Rose-John
Cytokines and neurotrophins interact in normal and diseased states.
Annals of the New York Academy of Sciences 2000;917():322-30.
1999: Mariam Klouche; Sucharit Bhakdi; M Hemmes; Stefan Rose-John
Novel path to activation of vascular smooth muscle cells: up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(8):4583-9.
1999: Karl-Josef Kallen; Peter Galle; Stefan Rose-John
New developments in IL-6 dependent biology and therapy: where do we stand and what are the options?
Expert opinion on investigational drugs 1999;8(9):1327-49.
1999: Pia März; Uwe Otten; Stefan Rose-John
Neural activities of IL-6-type cytokines often depend on soluble cytokine receptors.
The European journal of neuroscience 1999;11(9):2995-3004.
1999: Joachim Grötzinger; Thomas Kernebeck; Karl-Josef Kallen; Stefan Rose-John
IL-6 type cytokine receptor complexes: hexamer, tetramer or both?
Biological chemistry 1999;380(7-8):803-13.
1999: Petra Vollmer; B Oppmann; Nicole Voltz; Martina Fischer; Stefan Rose-John
A role for the immunoglobulin-like domain of the human IL-6 receptor. Intracellular protein transport and shedding.
European journal of biochemistry / FEBS 1999;263(2):438-46.
1999: Pia März; Klaus Heese; Beatrice Dimitriades-Schmutz; Stefan Rose-John; Uwe Otten
Role of interleukin-6 and soluble IL-6 receptor in region-specific induction of astrocytic differentiation and neurotrophin expression.
Glia 1999;26(3):191-200.
1999: Karl-Josef Kallen; Joachim Grötzinger; Eric Lelièvre; Petra Vollmer; Dorthe Aasland; C Renné; Jürgen Müllberg; K H Myer zum Büschenfelde; Hugues Gascan; Stefan Rose-John
Receptor recognition sites of cytokines are organized as exchangeable modules. Transfer of the leukemia inhibitory factor receptor-binding site from ciliary neurotrophic factor to interleukin-6.
The Journal of biological chemistry 1999;274(17):11859-67.
1999: Thomas Jostock; G Blinn; C Renné; Karl-Josef Kallen; Stefan Rose-John; Jürgen Müllberg
Immunoadhesins of interleukin-6 and the IL-6/soluble IL-6R fusion protein hyper-IL-6.
Journal of immunological methods 1999;223(2):171-83.
1999: M Thier; Pia März; Uwe Otten; Joachim Weis; Stefan Rose-John
Interleukin-6 (IL-6) and its soluble receptor support survival of sensory neurons.
Journal of neuroscience research 1999;55(4):411-22.
1999: Jürgen Müllberg; Petra Vollmer; K Althoff; Pia März; Stefan Rose-John
Generation and function of the soluble interleukin-6 receptor.
Biochemical Society transactions 1999;27(2):211-9.
1999: T Rakemann; M Niehof; Stefan Kubicka; M Fischer; Michael P Manns; Stefan Rose-John; Christian Trautwein
The designer cytokine hyper-interleukin-6 is a potent activator of STAT3-dependent gene transcription in vivo and in vitro.
The Journal of biological chemistry 1999;274(3):1257-66.
1998: M Peters; Albrecht M Müller; Stefan Rose-John
Interleukin-6 and soluble interleukin-6 receptor: direct stimulation of gp130 and hematopoiesis.
Blood 1998;92(10):3495-504.
1998: C Renné; Karl-Josef Kallen; Jürgen Müllberg; Thomas Jostock; Joachim Grötzinger; Stefan Rose-John
A new type of cytokine receptor antagonist directly targeting gp130.
The Journal of biological chemistry 1998;273(42):27213-9.
1998: M Peters; G Blinn; Fian K Solem; Martina Fischer; Karl-Hermann Meyer zum Büschenfelde; Stefan Rose-John
In vivo and in vitro activities of the gp130-stimulating designer cytokine Hyper-IL-6.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(7):3575-81.
1998: B Krebs; B Ackermann; Stefan Rose-John
Specific targeting of cytokine-secreting cells: a bispecific diabody recognizing human interleukin-6 and CD3 induces T cell-mediated killing.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1998;18(9):783-91.
1998: Suat Ozbek; Joachim Grötzinger; B Krebs; Martina Fischer; Axel Wollmer; Thomas Jostock; Jürgen Müllberg; Stefan Rose-John
The membrane proximal cytokine receptor domain of the human interleukin-6 receptor is sufficient for ligand binding but not for gp130 association.
The Journal of biological chemistry 1998;273(33):21374-9.
1998: Peter Schirmacher; M Peters; Gennaro Ciliberto; Manfred Blessing; Johannes Lotz; Karl-Hermann Meyer zum Büschenfelde; Stefan Rose-John
Hepatocellular hyperplasia, plasmacytoma formation, and extramedullary hematopoiesis in interleukin (IL)-6/soluble IL-6 receptor double-transgenic mice.
The American journal of pathology 1998;153(2):639-48.
1998: Pia März; JG Cheng; RA Gadient; Paul H Patterson; T Stoyan; Uwe Otten; Stefan Rose-John
Sympathetic neurons can produce and respond to interleukin 6.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(6):3251-6.
1998: B Krebs; H Griffin; G Winter; Stefan Rose-John
Recombinant human single chain Fv antibodies recognizing human interleukin-6. Specific targeting of cytokine-secreting cells.
The Journal of biological chemistry 1998;273(5):2858-65.
1997: Pia März; Klaus Heese; Christoph Hock; S Golombowski; Franz Müller-Spahn; Stefan Rose-John; Uwe Otten
Interleukin-6 (IL-6) and soluble forms of IL-6 receptors are not altered in cerebrospinal fluid of Alzheimer's disease patients.
Neuroscience letters 1997;239(1):29-32.
1997: Pia März; Thomas Herget; E Lang; Uwe Otten; Stefan Rose-John
Activation of gp130 by IL-6/soluble IL-6 receptor induces neuronal differentiation.
The European journal of neuroscience 1997;9(12):2765-73.
1997: M Peters; M Odenthal; Peter Schirmacher; Manfred Blessing; Elena Fattori; Gennaro Ciliberto; K H Meyer zum Buschenfelde; Stefan Rose-John
Soluble IL-6 receptor leads to a paracrine modulation of the IL-6-induced hepatic acute phase response in double transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(3):1474-81.
1997: Karl-Josef Kallen; K-H Meyer zum Büschenfelde; Stefan Rose-John
The therapeutic potential of interleukin-6 hyperagonists and antagonists.
Expert opinion on investigational drugs 1997;6(3):237-66.
1997: Percy A Knolle; E Löser; Ulrike Protzer; Rainer Duchmann; Edgar Schmitt; K-H Meyer zum Büschenfelde; Stefan Rose-John; Guido Gerken
Regulation of endotoxin-induced IL-6 production in liver sinusoidal endothelial cells and Kupffer cells by IL-10.
Clinical and experimental immunology 1997;107(3):555-61.
1997: M Peters; Peter Schirmacher; J Goldschmitt; M Odenthal; Christian Peschel; Elena Fattori; Gennaro Ciliberto; Hans P Dienes; Karl-Hermann Meyer zum Büschenfelde; Stefan Rose-John
Extramedullary expansion of hematopoietic progenitor cells in interleukin (IL)-6-sIL-6R double transgenic mice.
The Journal of experimental medicine 1997;185(4):755-66.
1997: Martina Fischer; J Goldschmitt; Christian Peschel; J P Brakenhoff; Karl-Josef Kallen; Axel Wollmer; Joachim Grötzinger; Stefan Rose-John
I. A bioactive designer cytokine for human hematopoietic progenitor cell expansion.
Nature biotechnology 1997;15(2):142-5.
1997: Joachim Grötzinger; G Kurapkat; Axel Wollmer; Michael Kalai; Stefan Rose-John
The family of the IL-6-type cytokines: specificity and promiscuity of the receptor complexes.
Proteins 1997;27(1):96-109.
1996: M Peters; K H Meyer zum Büschenfelde; Stefan Rose-John
The function of the soluble IL-6 receptor in vivo.
Immunology letters 1996;54(2-3):177-84.
1996: Petra Vollmer; M Peters; Marc Ehlers; H Yagame; T Matsuba; M Kondo; K Yasukawa; K H Büschenfelde; Stefan Rose-John
Yeast expression of the cytokine receptor domain of the soluble interleukin-6 receptor.
Journal of immunological methods 1996;199(1):47-54.
1996: J P Brakenhoff; H K Bos; Joachim Grötzinger; Stefan Rose-John; Lucien A Aarden
Identification of residues in the putative 5th helical region of human interleukin-6, important for activation of the IL-6 signal transducer, gp130.
FEBS letters 1996;395(2-3):235-40.
1996: Joanna Cichy; Stefan Rose-John; Juliusz Pryjma; James Travis
Effect of soluble interleukin-6 receptor on interleukin-6 synthesis in human skin fibroblasts.
Biochemical and biophysical research communications 1996;227(2):318-21.
1996: B Oppmann; T Stoyan; Martina Fischer; N Voltz; Pia März; Stefan Rose-John
Alternative assay procedures for cytokines and soluble receptors of the IL-6 family.
Journal of immunological methods 1996;195(1-2):153-9.
1996: Petra Vollmer; Iwan Walev; Stefan Rose-John; Sucharit Bhakdi
Novel pathogenic mechanism of microbial metalloproteinases: liberation of membrane-anchored molecules in biologically active form exemplified by studies with the human interleukin-6 receptor.
Infection and immunity 1996;64(9):3646-51.
1996: Marc Ehlers; Joachim Grötzinger; Martina Fischer; H K Bos; J P Brakenhoff; Stefan Rose-John
Identification of single amino acid residues of human IL-6 involved in receptor binding and signal initiation.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 1996;16(8):569-76.
1996: Iwan Walev; Petra Vollmer; Michael Palmer; Sucharit Bhakdi; Stefan Rose-John
Pore-forming toxins trigger shedding of receptors for interleukin 6 and lipopolysaccharide.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(15):7882-7.
1996: Michael Kalai; Félix A Montero-Julian; Joachim Grötzinger; Axel Wollmer; D Morelle; J Brochier; Stefan Rose-John; Peter C Heinrich; H Brailly; Jean Content
Participation of two Ser-Ser-Phe-Tyr repeats in interleukin-6 (IL-6)-binding sites of the human IL-6 receptor.
European journal of biochemistry / FEBS 1996;238(3):714-23.
1996: Elke Roeb; Stefan Rose-John
[Cytokines: biology and therapeutic relevance].
Deutsche medizinische Wochenschrift (1946) 1996;121(24):803-9.
1996: M Peters; S Jacobs; Marc Ehlers; Petra Vollmer; Jürgen Müllberg; E Wolf; G Brem; K H Meyer zum Büschenfelde; Stefan Rose-John
The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6.
The Journal of experimental medicine 1996;183(4):1399-406.
1996: A Kasza; R Korpula-Mastalerz; Stefan Rose-John; A Dubin
Biosynthesis and distribution of leucocyte elastase inhibitor. Production of recombinant inhibitor.
Acta biochimica Polonica 1996;43(3):497-501.
1995: R Simon; M Thier; A Krüttgen; Stefan Rose-John; O Weiergräber; Peter C Heinrich; J M Schröder; Joachim Weis
Human CNTF and related cytokines: effects on DRG neurone survival.
Neuroreport 1995;7(1):153-7.
1995: O Weiergräber; U Hemmann; Andrea Küster; Gerhard Müller-Newen; J Schneider; Stefan Rose-John; P Kurschat; J P Brakenhoff; M H Hart; S Stabel
Soluble human interleukin-6 receptor. Expression in insect cells, purification and characterization.
European journal of biochemistry / FEBS 1995;234(2):661-9.
1995: P Kurschat; Lutz Graeve; A Erren; P Gatsios; Stefan Rose-John; Elke Roeb; Harald Tschesche; Aleksander Koj; Peter C Heinrich
Expression of a biologically active murine tissue inhibitor of metalloproteinases-1 (TIMP-1) in baculovirus-infected insect cells. Purification and tissue distribution in the rat.
European journal of biochemistry / FEBS 1995;234(2):485-91.
1995: M Peters; E Roeb; D Pennica; K H Meyer zum Büschenfelde; Stefan Rose-John
A new hepatocyte stimulating factor: cardiotrophin-1 (CT-1).
FEBS letters 1995;372(2-3):177-80.
1995: F D de Hon; H K Klaasse Bos; S B Ebeling; Joachim Grötzinger; G Kurapkat; Stefan Rose-John; Lucien A Aarden; J P Brakenhoff
Leucine-58 in the putative 5th helical region of human interleukin (IL)-6 is important for activation of the IL-6 signal transducer, gp130.
FEBS letters 1995;369(2-3):187-91.
1995: Elke Roeb; Lutz Graeve; Jürgen Müllberg; Siegfried Matern; Stefan Rose-John
TIMP-1 protein expression is stimulated by IL-1 beta and IL-6 in primary rat hepatocytes.
Annals of the New York Academy of Sciences 1995;762():462-4.
1995: E Dittrich; C Gerhartz; Stefan Rose-John; Jürgen Müllberg; T Stoyan; Peter C Heinrich; Lutz Graeve
A region within the cytoplasmic domain of the interleukin-6 signal transducer gp130 important for ligand-induced endocytosis of the IL-6 receptor.
Annals of the New York Academy of Sciences 1995;762():410-2.
1995: Marc Ehlers; Joachim Grötzinger; F D de Hon; Jürgen Müllberg; J P Brakenhoff; Axel Wollmer; Stefan Rose-John
Residues 77-95 of the human interleuken-6 protein are responsible for receptor binding and residues 41-56 for signal transduction.
Annals of the New York Academy of Sciences 1995;762():400-2.
1995: Andrzej mackiewicz; M Wiznerowicz; E Roeb; J Nowak; T Pawlowski; H Baumann; Peter C Heinrich; Stefan Rose-John
Interleukin-6-type cytokines and their receptors for gene therapy of melanoma.
Annals of the New York Academy of Sciences 1995;762():361-73; discussion 373-4.
1995: Stefan Rose-John; Marc Ehlers; Joachim Grötzinger; Jürgen Müllberg
The soluble interleukin-6 receptor.
Annals of the New York Academy of Sciences 1995;762():207-20; discussion 220-1.
1995: Peter C Heinrich; Lutz Graeve; Stefan Rose-John; Jens Schneider-Mergener; E Dittrich; A Erren; C Gerhartz; U Hemann; C Lütticken; U Wegenka
Membrane-bound and soluble interleukin-6 receptor: studies on structure, regulation of expression, and signal transduction.
Annals of the New York Academy of Sciences 1995;762():222-36; discussion 236-7.
1995: F D de Hon; E ten Boekel; J Herrman; C Clement; Marc Ehlers; T Taga; K Yasukawa; Y Ohsugi; T Kishimoto; Stefan Rose-John
Functional distinction of two regions of human interleukin 6 important for signal transduction via gp130.
Cytokine 1995;7(5):398-407.
1995: Andrzej mackiewicz; A Górny; M Laciak; J Malicki; P Murawa; J Nowak; M Wiznerowicz; R G Hawley; Peter C Heinrich; Stefan Rose-John
Gene therapy of human melanoma. Immunization of patients with autologous tumor cells admixed with allogeneic melanoma cells secreting interleukin 6 and soluble interleukin 6 receptor.
Human gene therapy 1995;6(6):805-11.
1995: M Thier; R Simon; A Krüttgen; Stefan Rose-John; Peter C Heinrich; J M Schröder; Joachim Weis
Site-directed mutagenesis of human CNTF: functional analysis of recombinant variants.
Journal of neuroscience research 1995;40(6):826-35.
1995: Marc Ehlers; F D de Hon; H K Bos; U Horsten; G Kurapkat; H S van De Leur; Joachim Grötzinger; Axel Wollmer; J P Brakenhoff; Stefan Rose-John
Combining two mutations of human interleukin-6 that affect gp130 activation results in a potent interleukin-6 receptor antagonist on human myeloma cells.
The Journal of biological chemistry 1995;270(14):8158-63.
1995: U Horsten; Hildegard Schmitz-Van De Leur; Jürgen Müllberg; Peter C Heinrich; Stefan Rose-John
The membrane distal half of gp130 is responsible for the formation of a ternary complex with IL-6 and the IL-6 receptor.
FEBS letters 1995;360(1):43-6.
1995: Andrzej mackiewicz; M Wiznerowicz; E Roeb; A Karczewska; J Nowak; Peter C Heinrich; Stefan Rose-John
Soluble interleukin 6 receptor is biologically active in vivo.
Cytokine 1995;7(2):142-9.
1995: Elke Roeb; Stefan Rose-John; A Erren; D R Edwards; Siegfried Matern; Lutz Graeve; Peter C Heinrich
Tissue inhibitor of metalloproteinases-2 (TIMP-2) in rat liver cells is increased by lipopolysaccharide and prostaglandin E2.
FEBS letters 1995;357(1):33-6.
1994: F D de Hon; Marc Ehlers; Stefan Rose-John; S B Ebeling; H K Bos; Lucien A Aarden; J P Brakenhoff
Development of an interleukin (IL) 6 receptor antagonist that inhibits IL-6-dependent growth of human myeloma cells.
The Journal of experimental medicine 1994;180(6):2395-400.
1994: Marc Ehlers; Joachim Grötzinger; F D deHon; Jürgen Müllberg; J P Brakenhoff; J Liu; Axel Wollmer; Stefan Rose-John
Identification of two novel regions of human IL-6 responsible for receptor binding and signal transduction.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(4):1744-53.
1994: Elke Roeb; Lutz Graeve; Jürgen Müllberg; Siegfried Matern; Stefan Rose-John
TIMP-1 protein expression is stimulated by IL-1 beta and IL-6 in primary rat hepatocytes.
FEBS letters 1994;349(1):45-9.
1994: E Dittrich; Stefan Rose-John; C Gerhartz; Jürgen Müllberg; T Stoyan; K Yasukawa; Peter C Heinrich; Lutz Graeve
Identification of a region within the cytoplasmic domain of the interleukin-6 (IL-6) signal transducer gp130 important for ligand-induced endocytosis of the IL-6 receptor.
The Journal of biological chemistry 1994;269(29):19014-20.
1994: C Gerhartz; E Dittrich; T Stoyan; Stefan Rose-John; K Yasukawa; Peter C Heinrich; Lutz Graeve
Biosynthesis and half-life of the interleukin-6 receptor and its signal transducer gp130.
European journal of biochemistry / FEBS 1994;223(1):265-74.
1994: Stefan Rose-John; Peter C Heinrich
Soluble receptors for cytokines and growth factors: generation and biological function.
The Biochemical journal 1994;300 ( Pt 2)():281-90.
1994: Jürgen Müllberg; W Oberthür; F Lottspeich; E Mehl; E Dittrich; Lutz Graeve; Peter C Heinrich; Stefan Rose-John
The soluble human IL-6 receptor. Mutational characterization of the proteolytic cleavage site.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(10):4958-68.
1994: J P Brakenhoff; F D de Hon; V Fontaine; E ten Boekel; H Schooltink; Stefan Rose-John; Peter C Heinrich; Jean Content; Lucien A Aarden
Development of a human interleukin-6 receptor antagonist.
The Journal of biological chemistry 1994;269(1):86-93.
1993: Stefan Rose-John; H Schooltink; Hildegard Schmitz-Van De Leur; Jürgen Müllberg; Peter C Heinrich; Lutz Graeve
Intracellular retention of interleukin-6 abrogates signaling.
The Journal of biological chemistry 1993;268(29):22084-91.
1993: Jürgen Müllberg; E Dittrich; Lutz Graeve; C Gerhartz; K Yasukawa; T Taga; T Kishimoto; Peter C Heinrich; Stefan Rose-John
Differential shedding of the two subunits of the interleukin-6 receptor.
FEBS letters 1993;332(1-2):174-8.
1993: T Stoyan; U Michaelis; H Schooltink; M Van Dam; R Rudolph; Peter C Heinrich; Stefan Rose-John
Recombinant soluble human interleukin-6 receptor. Expression in Escherichia coli, renaturation and purification.
European journal of biochemistry / FEBS 1993;216(1):239-45.
1993: M van Dam; Jürgen Müllberg; H Schooltink; T Stoyan; J P Brakenhoff; Lutz Graeve; Peter C Heinrich; Stefan Rose-John
Structure-function analysis of interleukin-6 utilizing human/murine chimeric molecules. Involvement of two separate domains in receptor binding.
The Journal of biological chemistry 1993;268(20):15285-90.
1993: Tomasz Kordula; A Dubin; H Schooltink; Aleksander Koj; Peter C Heinrich; Stefan Rose-John
Molecular cloning and expression of an intracellular serpin: an elastase inhibitor from horse leucocytes.
The Biochemical journal 1993;293 ( Pt 1)():187-93.
1993: D Pietzko; D Zohlnhöfer; Lutz Graeve; D Fleischer; T Stoyan; H Schooltink; Stefan Rose-John; Peter C Heinrich
The hepatic interleukin-6 receptor. Studies on its structure and regulation by phorbol 12-myristate 13-acetate-dexamethasone.
The Journal of biological chemistry 1993;268(6):4250-8.
1993: Jürgen Müllberg; H Schooltink; T Stoyan; M Günther; Lutz Graeve; G Buse; Andrzej mackiewicz; Peter C Heinrich; Stefan Rose-John
The soluble interleukin-6 receptor is generated by shedding.
European journal of immunology 1993;23(2):473-80.
1992: H Schooltink; T Stoyan; Elke Roeb; Peter C Heinrich; Stefan Rose-John
Ciliary neurotrophic factor induces acute-phase protein expression in hepatocytes.
FEBS letters 1992;314(3):280-4.
1992: Jürgen Müllberg; H Schooltink; T Stoyan; Peter C Heinrich; Stefan Rose-John
Protein kinase C activity is rate limiting for shedding of the interleukin-6 receptor.
Biochemical and biophysical research communications 1992;189(2):794-800.
1992: Tomasz Kordula; I Güttgemann; Stefan Rose-John; Elke Roeb; A Osthues; Harald Tschesche; Aleksander Koj; Peter C Heinrich; Lutz Graeve
Synthesis of tissue inhibitor of metalloproteinase-1 (TIMP-1) in human hepatoma cells (HepG2). Up-regulation by interleukin-6 and transforming growth factor beta 1.
FEBS letters 1992;313(2):143-7.
1992: Andrzej mackiewicz; H Schooltink; Peter C Heinrich; Stefan Rose-John
Complex of soluble human IL-6-receptor/IL-6 up-regulates expression of acute-phase proteins.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(6):2021-7.
1992: Andrzej mackiewicz; Stefan Rose-John; H Schooltink; M Laciak; A Górny; Peter C Heinrich
Soluble human interleukin-6-receptor modulates interleukin-6-dependent N-glycosylation of alpha 1-protease inhibitor secreted by HepG2 cells.
FEBS letters 1992;306(2-3):257-61.
1992: D Zohlnhöfer; Lutz Graeve; Stefan Rose-John; H Schooltink; E Dittrich; Peter C Heinrich
The hepatic interleukin-6 receptor. Down-regulation of the interleukin-6 binding subunit (gp80) by its ligand.
FEBS letters 1992;306(2-3):219-22.
1992: H Schooltink; Hildegard Schmitz-Van De Leur; Peter C Heinrich; Stefan Rose-John
Up-regulation of the interleukin-6-signal transducing protein (gp130) by interleukin-6 and dexamethasone in HepG2 cells.
FEBS letters 1992;297(3):263-5.
1992: Tomasz Kordula; Stefan Rose-John; Peter C Heinrich; Aleksander Koj
Interferon-gamma regulates alpha 2-macroglobulin and alpha 1-antichymotrypsin expression on the pretranslational level in HepG2 cells.
Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society 1992;30(4):147-9.
1991: H Schooltink; T Stoyan; D Lenz; H Schmitz; T Hirano; T Kishimoto; Peter C Heinrich; Stefan Rose-John
Structural and functional studies on the human hepatic interleukin-6 receptor. Molecular cloning and overexpression in HepG2 cells.
The Biochemical journal 1991;277 ( Pt 3)():659-64.
1991: C Lütticken; A Krüttgen; C Möller; Peter C Heinrich; Stefan Rose-John
Evidence for the importance of a positive charge and an alpha-helical structure of the C-terminus for biological activity of human IL-6.
FEBS letters 1991;282(2):265-7.
1991: Stefan Rose-John; E Hipp; D Lenz; L G Legrés; H Korr; T Hirano; T Kishimoto; Peter C Heinrich
Structural and functional studies on the human interleukin-6 receptor. Binding, cross-linking, internalization, and degradation of interleukin-6 by fibroblasts transfected with human interleukin-6-receptor cDNA.
The Journal of biological chemistry 1991;266(6):3841-6.
1990: A Krüttgen; Stefan Rose-John; G Dufhues; S Bender; C Lütticken; P Freyer; Peter C Heinrich
The three carboxy-terminal amino acids of human interleukin-6 are essential for its biological activity.
FEBS letters 1990;273(1-2):95-8.
1990: Stefan Rose-John; H Schooltink; D Lenz; E Hipp; G Dufhues; H Schmitz; X Schiel; T Hirano; T Kishimoto; Peter C Heinrich
Studies on the structure and regulation of the human hepatic interleukin-6 receptor.
European journal of biochemistry / FEBS 1990;190(1):79-83.
1990: X Schiel; Stefan Rose-John; G Dufhues; H Schooltink; V Gross; Peter C Heinrich
Microheterogeneity of human interleukin 6 synthesized by transfected NIH/3T3 cells: comparison with human monocytes, fibroblasts and endothelial cells.
European journal of immunology 1990;20(4):883-7.
1990: A Krüttgen; Stefan Rose-John; C Möller; B Wroblowski; Axel Wollmer; Jürgen Müllberg; T Hirano; T Kishimoto; Peter C Heinrich
Structure-function analysis of human interleukin-6. Evidence for the involvement of the carboxy-terminus in function.
FEBS letters 1990;262(2):323-6.