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William Rose

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Sharnelle S Phifer; Dongho Lee; Eun-Kyoung Seo; Nam-Cheol Kim; Tyler N Graf; David Kroll; Hernán A Navarro; Robert A Izydore; Francisco Jiménez; Ricardo Garcia; William C Rose; Craig R Fairchild; Robert Wild; D Doel Soejarto; Norman R Farnsworth; A Douglas Kinghorn; Nicholas H. Oberlies; Monroe E Wall; Mansukh C Wani
Alvaradoins E-N, antitumor and cytotoxic anthracenone C-glycosides from the leaves of Alvaradoa haitiensis.
William C Rose; Punit Marathe; Graham R Jang; Thomas M Monticello; Balu N Balasubramanian; Byron Long; Craig R Fairchild; Monroe E Wall; Mansukh C Wani
Novel fluoro-substituted camptothecins: in vivo antitumor activity, reduced gastrointestinal toxicity and pharmacokinetic characterization.
D Doel Soejarto; Hong-Jie Zhang; Harry H S Fong; Ghee Teng Tan; Cui-Ying Ma; Charlotte Gyllenhaal; Mary C Riley; Marian R Kadushin; Scott Franzblau; Truong Quang Bich; Nguyen Manh Cuong; Nguyen Tien Hiep; Phan Ke Loc; Le Thi Xuan; Nong Van Hai; Nguyen Van Hung; Nguyen Quyet Chien; Le Tran Binh; Bui Minh Vu; Ho Minh Ly; Bounhoong Southavong; Kongmany Sydara; Somsanith Bouamanivong; John M Pezzuto; William C Rose; Gregg R Dietzman; Byron E Miller; Tran Van Thuy
"Studies on biodiversity of Vietnam and Laos" 1998-2005: examining the impact.

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2007: Sharnelle S Phifer; Dongho Lee; Eun-Kyoung Seo; Nam-Cheol Kim; Tyler N Graf; David Kroll; Hernán A Navarro; Robert A Izydore; Francisco Jiménez; Ricardo Garcia; William C Rose; Craig R Fairchild; Robert Wild; D Doel Soejarto; Norman R Farnsworth; A Douglas Kinghorn; Nicholas H. Oberlies; Monroe E Wall; Mansukh C Wani
Alvaradoins E-N, antitumor and cytotoxic anthracenone C-glycosides from the leaves of Alvaradoa haitiensis.
Journal of natural products 2007;70(6):954-61.
2006: William C Rose; Punit Marathe; Graham R Jang; Thomas M Monticello; Balu N Balasubramanian; Byron Long; Craig R Fairchild; Monroe E Wall; Mansukh C Wani
Novel fluoro-substituted camptothecins: in vivo antitumor activity, reduced gastrointestinal toxicity and pharmacokinetic characterization.
Cancer chemotherapy and pharmacology 2006;58(1):73-85.
2006: D Doel Soejarto; Hong-Jie Zhang; Harry H S Fong; Ghee Teng Tan; Cui-Ying Ma; Charlotte Gyllenhaal; Mary C Riley; Marian R Kadushin; Scott Franzblau; Truong Quang Bich; Nguyen Manh Cuong; Nguyen Tien Hiep; Phan Ke Loc; Le Thi Xuan; Nong Van Hai; Nguyen Van Hung; Nguyen Quyet Chien; Le Tran Binh; Bui Minh Vu; Ho Minh Ly; Bounhoong Southavong; Kongmany Sydara; Somsanith Bouamanivong; John M Pezzuto; William C Rose; Gregg R Dietzman; Byron E Miller; Tran Van Thuy
"Studies on biodiversity of Vietnam and Laos" 1998-2005: examining the impact.
Journal of natural products 2006;69(3):473-81.
2006: Robert Wild; Krista Fager; Christine Flefleh; David Kan; Ivan Inigo; Stephen Castaneda; Feng R Luo; Amy Camuso; Kelly McGlinchey; William C Rose
Cetuximab preclinical antitumor activity (monotherapy and combination based) is not predicted by relative total or activated epidermal growth factor receptor tumor expression levels.
Molecular cancer therapeutics 2006;5(1):104-13.
2005: Feng R Luo; Zheng Yang; H Dong; Amy Camuso; Kelly McGlinchey; Krista Fager; Christine Flefleh; David Kan; Ivan Inigo; Stephen Castaneda; William C Rose; Robert A Kramer; Robert Wild; Francis Y Lee
Correlation of pharmacokinetics with the antitumor activity of Cetuximab in nude mice bearing the GEO human colon carcinoma xenograft.
Cancer chemotherapy and pharmacology 2005;56(5):455-64.
2005: D Doel Soejarto; Harry H S Fong; Ghee Teng Tan; Hong-Jie Zhang; Cui-Ying Ma; Scott Franzblau; Charlotte Gyllenhaal; M C Riley; Marian R Kadushin; John M Pezzuto; L T Xuan; Nguyen Tien Hiep; Nguyen Van Hung; B M Vu; P K Loc; L X Dac; L T Binh; N Q Chien; N V Hai; Truong Quang Bich; Nguyen Manh Cuong; Bounhoong Southavong; Kongmany Sydara; Somsanith Bouamanivong; Ho Minh Ly; Tran Van Thuy; William C Rose; G R Dietzman
Ethnobotany/ethnopharmacology and mass bioprospecting: issues on intellectual property and benefit-sharing.
Journal of ethnopharmacology 2005;100(1-2):15-22.
2005: Mark G Saulnier; Balu N Balasubramanian; Byron H Long; David B Frennesson; Edward Ruediger; Kurt Zimmermann; Jeffrey T Eummer; Denis R St Laurent; Karen M Stoffan; B Narasimhulu Naidu; Mikael Mahler; Francis Beaulieu; Carol Bachand; Francis Y Lee; Craig R Fairchild; Linda K Stadnick; William C Rose; Carola Solomon; Henry Wong; Alain Martel; John J Wright; Robert Kramer; David Langley; Dolatrai M Vyas
Discovery of a fluoroindolo[2,3-a]carbazole clinical candidate with broad spectrum antitumor activity in preclinical tumor models superior to the marketed oncology drug, CPT-11.
Journal of medicinal chemistry 2005;48(7):2258-61.
2004: William C Rose; Robert Wild
Therapeutic synergy of oral taxane BMS-275183 and cetuximab versus human tumor xenografts.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(21):7413-7.
2004: James Tarrant; Donald Cook; Craig R Fairchild; John F Kadow; Byron H Long; William C Rose; Dolatrai M Vyas
Synthesis and biological activity of macrocyclic taxane analogues.
Bioorganic & medicinal chemistry letters 2004;14(10):2555-8.
2004: Bang Yeon Hwang; Bao-Ning Su; Heebyung Chai; Qiuwen Mi; Leonardus B S Kardono; Johar J Afriastini; Soedarsono Riswan; Bernard D Santarsiero; Andrew D Mesecar; Robert Wild; Craig R Fairchild; Gregory D Vite; William C Rose; Norman R Farnsworth; Patrick Jonas; John M Pezzuto; Steven M Swanson; A Douglas Kinghorn
Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris.
The Journal of organic chemistry 2004;69(10):3350-8.
2004: Balu N Balasubramanian; Denis R St Laurent; Mark G Saulnier; Byron H Long; Carol Bachand; Francis Beaulieu; Wendy Clarke; Milind Deshpande; Jeffrey Eummer; Craig R Fairchild; David B Frennesson; Robert Kramer; Francis Y Lee; Mikael Mahler; Alain Martel; B Narasimhulu Naidu; William C Rose; John Russell; Edward Ruediger; Carola Solomon; Karen M Stoffan; Henry Wong; John J Wright; Kurt Zimmermann; Dolatrai M Vyas
Design and synthesis of a fluoroindolocarbazole series as selective topoisomerase I active agents. Discovery of water-soluble 3,9-difluoro-12,13-dihydro-13-[6-amino-beta-D-glucopyranosyl]-5H,13H-benzo[b]- thienyl[2,3-a]pyrrolo[3,4-c]carbazole- 5,7(6H)-dione (BMS-251873) with curative antitumor activity against prostate carcinoma xenograft tumor model.
Journal of medicinal chemistry 2004;47(7):1609-12.
2003: Harold Mastalerz; Donald Cook; Craig R Fairchild; Steven B Hansel; Walter Johnson; John F Kadow; Byron H Long; William C Rose; James Tarrant; Mu-Jen Wu; May Quifen Xue; Guifen Zhang; Mary Zoeckler; Dolatrai M Vyas
The discovery of BMS-275183: an orally efficacious novel taxane.
Bioorganic & medicinal chemistry 2003;11(20):4315-23.
2002: Byron H Long; William C Rose; Dolatrai M Vyas; James A Matson; Salvatore Forenza
Discovery of antitumor indolocarbazoles: rebeccamycin, NSC 655649, and fluoroindolocarbazoles.
Current medicinal chemistry. Anti-cancer agents 2002;2(2):255-66.
2002: Eun-Kyoung Seo; Nam-Cheol Kim; Mansukh C Wani; Monroe E Wall; Hernán A Navarro; Jason P Burgess; Kazuko Kawanishi; Leonardus B S Kardono; Soedarsono Riswan; William C Rose; Craig R Fairchild; Norman R Farnsworth; A Douglas Kinghorn
Cytotoxic prenylated xanthones and the unusual compounds anthraquinobenzophenones from Cratoxylum sumatranum.
Journal of natural products 2002;65(3):299-305.
2001: T J Altstadt; Craig R Fairchild; J Golik; KA Johnston; John F Kadow; Francis Y Lee; Byron H Long; William C Rose; Dolatrai M Vyas; Harvey Wong; Mu-Jen Wu; Mark Wittman
Synthesis and antitumor activity of novel C-7 paclitaxel ethers: discovery of BMS-184476.
Journal of medicinal chemistry 2001;44(26):4577-83.
2001: William C Rose; Francis Y Lee; Craig R Fairchild; M Lynch; Thomas M Monticello; Robert A Kramer; swam manne
Preclinical antitumor activity of BMS-214662, a highly apoptotic and novel farnesyltransferase inhibitor.
Cancer research 2001;61(20):7507-17.
2001: William C Rose; Byron H Long; Craig R Fairchild; Francis Y Lee; John F Kadow
Preclinical pharmacology of BMS-275183, an orally active taxane.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(7):2016-21.
2001: Francis Y Lee; Robert M Borzilleri; Craig R Fairchild; Soong-Hoon Kim; Byron H Long; C Reventos-Suarez; Gregory D Vite; William C Rose; Robert A Kramer
BMS-247550: a novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(5):1429-37.
2001: Mark Wittman; John F Kadow; Dolatrai M Vyas; F L Lee; William C Rose; Byron H Long; Craig R Fairchild; K Johnston
Synthesis and antitumor activity of novel paclitaxel-chlorambucil hybrids.
Bioorganic & medicinal chemistry letters 2001;11(6):811-4.
2001: Mark Wittman; T J Altstadt; Craig R Fairchild; Steven B Hansel; K Johnston; John F Kadow; Byron H Long; William C Rose; Dolatrai M Vyas; Mu-Jen Wu; Mary Zoeckler
Synthesis of metabolically blocked paclitaxel analogues.
Bioorganic & medicinal chemistry letters 2001;11(6):809-10.
2001: William C Rose; Craig R Fairchild; F Y Lee
Preclinical antitumor activity of two novel taxanes.
Cancer chemotherapy and pharmacology 2001;47(2):97-105.
2001: K S Lam; D R Schroeder; J M Veitch; K L Colson; J A Matson; William C Rose; T W Doyle; S Forenza
Production, isolation and structure determination of novel fluoroindolocarbazoles from Saccharothrix aerocolonigenes ATCC 39243.
The Journal of antibiotics 2001;54(1):1-9.
2000: John T Hunt; CZ Ding; Roberta Batorsky; Mark S Bednarz; Rajeev S Bhide; Y Cho; S Chong; Sam Chao; Johnni Gullo-Brown; P Guo; Soong-Hoon Kim; Francis Y Lee; Katerina Leftheris; A Miller; Toomas Mitt; M Patel; B A Penhallow; Carolyn S Ricca; William C Rose; R Schmidt; William A Slusarchyk; Gregory D Vite; swam manne
Discovery of (R)-7-cyano-2,3,4, 5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a farnesyltransferase inhibitor with potent preclinical antitumor activity.
Journal of medicinal chemistry 2000;43(20):3587-95.
2000: M Xue; Byron H Long; Craig R Fairchild; K Johnston; William C Rose; John F Kadow; Dolatrai M Vyas; S H Chen
Structure-activity relationships study at the 3'-N position of paclitaxel. Part 2: synthesis and biological evaluation of 3'-N-thiourea- and 3'-N-thiocarbamate-bearing paclitaxel analogues.
Bioorganic & medicinal chemistry letters 2000;10(12):1327-31.
2000: William C Rose; Francis Y Lee; J Golik; John F Kadow
Preclinical oral antitumor activity of BMS-185660, a paclitaxel derivative.
Cancer chemotherapy and pharmacology 2000;46(3):246-50.
1999: CZ Ding; Roberta Batorsky; Rajeev S Bhide; H J Chao; Y Cho; S Chong; Johnni Gullo-Brown; P Guo; Soong-Hoon Kim; Francis Lee; Katerina Leftheris; A Miller; Toomas Mitt; M Patel; B A Penhallow; Carolyn S Ricca; William C Rose; R Schmidt; William A Slusarchyk; Gregory D Vite; N Yan; swam manne; John T Hunt
Discovery and structure-activity relationships of imidazole-containing tetrahydrobenzodiazepine inhibitors of farnesyltransferase.
Journal of medicinal chemistry 1999;42(25):5241-53.
1997: MD Chordia; David G I Kingston; E Hamel; C M Lin; Byron H Long; C A Fairchild; KA Johnston; William C Rose
Synthesis and biological activity of A-nor-paclitaxel analogues.
Bioorganic & medicinal chemistry 1997;5(5):941-7.
1997: William C Rose
Combination chemotherapy involving orally administered etoposide and JM-216 in murine tumor models.
Cancer chemotherapy and pharmacology 1997;40(1):51-6.
1997: William C Rose; J L Clark; Francis Y Lee; A M Casazza
Preclinical antitumor activity of water-soluble paclitaxel derivatives.
Cancer chemotherapy and pharmacology 1997;39(6):486-92.
1995: Kin S Lam; JA Veitch; J Golik; William C Rose; T W Doyle; S Forenza
Production and isolation of two novel esperamicins in a chemically defined medium.
The Journal of antibiotics 1995;48(12):1497-501.
1995: Kin S Lam; D R Gustavson; G A Hesler; T T Dabrah; J A Matson; R L Berry; William C Rose; S Forenza
Korkormicins, novel depsipeptide antitumor antibiotics from Micromonospora sp C39500: fermentation, precursor directed biosynthesis and biological activities.
Journal of industrial microbiology 1995;15(1):60-5.
1993: F Mayerl; Q Gao; Stella Huang; Steven E Klohr; J A Matson; D R Gustavson; D M Pirnik; R L Berry; C Fairchild; William C Rose
Eupenifeldin, a novel cytotoxic bistropolone from Eupenicillium brefeldianum.
The Journal of antibiotics 1993;46(7):1082-8.
1993: William C Rose; A R Crosswell; J E Schurig; A M Casazza
Preclinical antitumor activity of orally administered platinum (IV) complexes.
Cancer chemotherapy and pharmacology 1993;32(3):197-203.
1992: W T Bradner; J J Catino; Byron H Long; William C Rose; J E Schurig
Experimental tumor inhibitory and toxic properties of the mitomycin A analogue 7-(2-hydroxyethoxy) mitosane (BMY-25551).
Anticancer research 1992;12(3):959-64.
1990: William C Rose; G A Basler
In vivo model development of cisplatin-resistant and -sensitive A2780 human ovarian carcinomas.
In vivo (Athens, Greece) 1990;4(6):391-6.
1990: William C Rose; A R Crosswell; J J Bronson; J C Martin
In vivo antitumor activity of 9-[(2-phosphonylmethoxy)ethyl]-guanine and related phosphonate nucleotide analogues.
Journal of the National Cancer Institute 1990;82(6):510-2.
1990: J E Schurig; William C Rose; H Kamei; Y Nishiyama; W T Bradner; D A Stringfellow
Experimental antitumor activity of BMY-28175 a new fermentation derived antitumor agent.
Investigational new drugs 1990;8(1):7-15.
1990: William C Rose; G A Basler; Pamela A Trail; M Saulnier; A R Crosswell; A M Casazza
Preclinical antitumor activity of a soluble etoposide analog, BMY-40481-30.
Investigational new drugs 1990;8 Suppl 1():S25-32.
1990: W T Bradner; William C Rose; J E Schurig; A P Florczyk
Antitumor activity and toxicity in animals of N-7[2-(4-nitrophenyldithio) ethyl] mitomycin C (BMY-25067).
Investigational new drugs 1990;8 Suppl 1():S1-7.
1990: T Kaneko; H Wong; William C Rose; W T Bradner; T W Doyle
Cyclic acetal derivatives of mitomycin C.
The Journal of antibiotics 1990;43(1):122-4.
1989: J A Matson; William C Rose; J A Bush; R Myllymaki; W T Bradner; T W Doyle
Antitumor activity of chrysomycins M and V.
The Journal of antibiotics 1989;42(9):1446-8.
1989: Pamela A Trail; William C Rose
Development of a human xenograft model for the evaluation of monoclonal antibody L6-mitomycin immunoconjugates.
In vivo (Athens, Greece) 1989;3(5):319-24.
1989: J E Schurig; W T Bradner; G A Basler; William C Rose
Experimental antitumor activity of BMY-28090, a new antitumor antibiotic.
Investigational new drugs 1989;7(2-3):173-8.
1989: D M Vyas; D Benigni; William C Rose; W T Bradner; T W Doyle
Synthesis and in vivo antitumor activity of novel mitomycin A disulfide analogs.
The Journal of antibiotics 1989;42(7):1199-201.
1989: M G Saulnier; D M Vyas; D R Langley; T W Doyle; William C Rose; A R Crosswell; Byron H Long
E-ring desoxy analogues of etoposide.
Journal of medicinal chemistry 1989;32(7):1418-20.
1989: William C Rose; G A Basler
An in vivo human tumor xenograft model of etoposide resistance.
In vivo (Athens, Greece) 1989;3(4):249-53.
1988: William C Rose; J E Schurig; J B Meeker
Correlation of in vitro cytotoxicity with preclinical in vivo antitumor activity.
Anticancer research 1988;8(3):355-67.
1987: William C Rose; J B Huftalen; W T Bradner; J E Schurig
In vivo characterization of P388 leukemia resistant to mitomycin C.
In vivo (Athens, Greece) 1987;1(1):47-52.
1985: W T Bradner; William C Rose; J E Schurig; A P Florczyk; J B Huftalen; J J Catino
Antitumor activity and toxicity in animals of BMY-25282, a new mitomycin derivative.
Cancer research 1985;45(12 Pt 1):6475-81.
1985: William C Rose; J E Schurig
Preclinical antitumor and toxicologic profile of carboplatin.
Cancer treatment reviews 1985;12 Suppl A():1-19.
1985: T Kaneko; H Wong; H G Howell; William C Rose; W T Bradner; T W Doyle
Reductive amination of 3-ketoanguidin and antitumor activity of the products.
Journal of medicinal chemistry 1985;28(7):958-60.
1985: T Kaneko; H Wong; T W Doyle; William C Rose; W T Bradner
Bicyclic and tricyclic analogues of anthramycin.
Journal of medicinal chemistry 1985;28(3):388-92.
1984: W T Bradner; William C Rose; J E Schurig; A Schlein; J B Huftalen
Antitumor activity and toxicity in animals of RR-150 (7-cysteaminomitosane), a new mitomycin derivative.
Cancer research 1984;44(12 Pt 1):5619-23.
1984: William C Rose; F C Reed; P Siminoff; W T Bradner
Immunotherapy of Madison 109 lung carcinoma and other murine tumors using lentinan.
Cancer research 1984;44(4):1368-73.
1984: J E Schurig; William C Rose; R S Hirth; A Schlein; J B Huftalen; A P Florczyk; W T Bradner
Tallysomycin S10b: experimental antitumor activity and toxicity.
Cancer chemotherapy and pharmacology 1984;13(3):164-70.
1983: William C Rose; J E Schurig; J B Huftalen; W T Bradner
Experimental antitumor activity and toxicity of a new chemotherapeutic agent, BBM 928A.
Cancer research 1983;43(4):1504-10.
1982: J E Schurig; A P Florczyk; William C Rose; W T Bradner
Antiemetic activity of butorphanol against cisplatin-induced emesis in ferrets and dogs.
Cancer treatment reports 1982;66(10):1831-5.
1982: William C Rose; J E Schurig; J B Huftalen; W T Bradner
Antitumor activity and toxicity of cisplatin analogs.
Cancer treatment reports 1982;66(1):135-46.