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Antony Rosen

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Tricia R Cottrell; John C Hall; Antony Rosen; Livia Casciola-Rosen
Identification of novel autoantigens by a triangulation approach.
Antony Rosen; Livia Casciola-Rosen
Comparing and contrasting muscle disease across the continuum highlights shared pathways and presentations of muscle dysfunction.
John C Hall; Efstathia K Kapsogeorgou; Athanasios G Tzioufas; ALAN BAER; Alan E Berger; Livia Casciola-Rosen; Chris Cheadle; Antony Rosen
Precise probes of type II interferon activity define the origin of interferon signatures in target tissues in rheumatic diseases.

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All Publications

2012: Tricia R Cottrell; John C Hall; Antony Rosen; Livia Casciola-Rosen
Identification of novel autoantigens by a triangulation approach.
Journal of immunological methods 2012;385(1-2):35-44.
2012: Antony Rosen; Livia Casciola-Rosen
Comparing and contrasting muscle disease across the continuum highlights shared pathways and presentations of muscle dysfunction.
Current opinion in rheumatology 2012;24(6):595-6.
2012: John C Hall; Efstathia K Kapsogeorgou; Athanasios G Tzioufas; ALAN BAER; Alan E Berger; Livia Casciola-Rosen; Chris Cheadle; Antony Rosen
Precise probes of type II interferon activity define the origin of interferon signatures in target tissues in rheumatic diseases.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(43):17609-14.
2012: Jennifer S Mammen; Erik Pulkstenis; Antony Rosen; G. SUBRAMANIAN; Sharon R Ghazarian; Paul W Ladenson
Phenotypes of interferon-α-induced thyroid dysfunction among patients treated for hepatitis C are associated with pretreatment serum TSH and female sex.
The Journal of clinical endocrinology and metabolism 2012;97(9):3270-6.
2012: Neal F Chaisson; Sonye K Danoff; David Fiorentino; Ana-Maria Orbai; Julie Paik; Livia Casciola-Rosen; Antony Rosen
A novel dermato-pulmonary syndrome associated with MDA-5 antibodies: report of 2 cases and review of the literature.
Medicine 2012;91(4):220-8.
2012: Livia Casciola-Rosen; Lisa Christopher-Stine; John C Hall; Alex Mammen; Antony Rosen
Isolated elevation of aldolase in the serum of myositis patients: a potential biomarker of damaged early regenerating muscle cells.
Clinical and experimental rheumatology 2012;30(4):548-53.
2012: Jin Kyun Park; Antony Rosen; Frederic B Askin; Jon T Giles; Marc K Halushka; Stuart M Levine
Increased generation of TRAP expressing multinucleated giant cells in patients with granulomatosis with polyangiitis.
PloS one 2012;7(8):e42659.
2012: Jon T Giles; Felipe Andrade; Joan M Bathon; Clifton O Bingham; Justyna Fert-Bober; Karen Fox-Talbot; Dimitrios Pappas; Jin Kyun Park; Antony Rosen; Jennifer E Van Eyk; Marc K Halushka
Myocardial citrullination in rheumatoid arthritis: a correlative histopathologic study.
Arthritis research & therapy 2012;14(1):R39.
2012: Erika Darrah; Jon T Giles; Antony Rosen; Felipe Andrade
Peptidylarginine deiminase 2, 3 and 4 have distinct specificities against cellular substrates: novel insights into autoantigen selection in rheumatoid arthritis.
Annals of the rheumatic diseases 2012;71(1):92-8.
2011: Thomas Grader-Beck; Antony Rosen; David Smith; Stephan von Gunten; Francesco Boin; Bruce S Bochner
Antibodies recognising sulfated carbohydrates are prevalent in systemic sclerosis and associated with pulmonary vascular disease.
Annals of the rheumatic diseases 2011;70(12):2218-24.
2011: Ami Shah; Antony Rosen
Cancer and systemic sclerosis: novel insights into pathogenesis and clinical implications.
Current opinion in rheumatology 2011;23(6):530-5.
2011: David Fiorentino; Antony Rosen; Jeff Zwerner; Lorinda Chung; Livia Casciola-Rosen
The mucocutaneous and systemic phenotype of dermatomyositis patients with antibodies to MDA5 (CADM-140): a retrospective study.
Journal of the American Academy of Dermatology 2011;65(1):25-34.
2011: Alex Mammen; Tae Chung; Lisa Christopher-Stine; Paul Rosen; Antony Rosen; Kimberly R Doering; Livia Casciola-Rosen
Autoantibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase in patients with statin-associated autoimmune myopathy.
Arthritis and rheumatism 2011;63(3):713-21.
2011: ANDREW MAMMEN; Nisha Badders; James A Mahoney; Amanda St Germain; Antony Rosen; J Paul Taylor; Sarah Spinette
A novel conserved isoform of the ubiquitin ligase UFD2a/UBE4B is expressed exclusively in mature striated muscle cells.
PloS one 2011;6(12):e28861.
2011: Sangeeta D Sule; Antony Rosen; Michelle Petri; Ehtisham Akhter; Felipe Andrade
Abnormal production of pro- and anti-inflammatory cytokines by lupus monocytes in response to apoptotic cells.
PloS one 2011;6(3):e17495.
2010: Ami Shah; Antony Rosen; Laura K Hummers; Fredrick M Wigley; Livia Casciola-Rosen
Close temporal relationship between onset of cancer and scleroderma in patients with RNA polymerase I/III antibodies.
Arthritis and rheumatism 2010;62(9):2787-95.
2010: Jason R Kolfenbach; Kevin D Deane; Lezlie A Derber; Colin I O'Donnell; William R Gilliland; Jess D Edison; Antony Rosen; Erika Darrah; Jill M Norris; V Michael Holers
Autoimmunity to peptidyl arginine deiminase type 4 precedes clinical onset of rheumatoid arthritis.
Arthritis and rheumatism 2010;62(9):2633-9.
2010: Amit Golding; Antony Rosen; Michelle Petri; Ehtisham Akhter; Felipe Andrade
Interferon-alpha regulates the dynamic balance between human activated regulatory and effector T cells: implications for antiviral and autoimmune responses.
Immunology 2010;131(1):107-17.
2010: Felipe Andrade; Erika Darrah; Marjan Gucek; Robert N Cole; Antony Rosen; Xiaoming Zhu
Autocitrullination of human peptidyl arginine deiminase type 4 regulates protein citrullination during cell activation.
Arthritis and rheumatism 2010;62(6):1630-40.
2010: Brian Niland; Gabriella Miklossy; Katalin Banki; William E Biddison; Livia Casciola-Rosen; Antony Rosen; Denis Martinvalet; Judy Lieberman; Andras Perl
Cleavage of transaldolase by granzyme B causes the loss of enzymatic activity with retention of antigenicity for multiple sclerosis patients.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(7):4025-32.
2010: E Darrah; Antony Rosen
Granzyme B cleavage of autoantigens in autoimmunity.
Cell death and differentiation 2010;17(4):624-32.
2010: John C Hall; Antony Rosen
Type I interferons: crucial participants in disease amplification in autoimmunity.
Nature reviews. Rheumatology 2010;6(1):40-9.
2009: ANDREW MAMMEN; Livia Casciola-Rosen; John C Hall; Lisa Christopher-Stine; Andrea M Corse; Antony Rosen
Expression of the dermatomyositis autoantigen Mi-2 in regenerating muscle.
Arthritis and rheumatism 2009;60(12):3784-93.
2009: Francesco Boin; Stefano Franchini; ELIZABETH COLANTUONI; Antony Rosen; Fredrick M Wigley; Livia Casciola-Rosen
Independent association of anti-beta(2)-glycoprotein I antibodies with macrovascular disease and mortality in scleroderma patients.
Arthritis and rheumatism 2009;60(8):2480-9.
2009: Tomeka Suber; Antony Rosen
Apoptotic cell blebs: repositories of autoantigens and contributors to immune context.
Arthritis and rheumatism 2009;60(8):2216-9.
2009: Antony Rosen; Livia Casciola-Rosen
Autoantigens in systemic autoimmunity: critical partner in pathogenesis.
Journal of internal medicine 2009;265(6):625-31.
2009: Chris Cheadle; Tonya Watkins; JINSHUI FAN; Marc A Williams; Steven Georas; John Hall; Antony Rosen; Kathleen C Barnes
GSMA: Gene Set Matrix Analysis, An Automated Method for Rapid Hypothesis Testing of Gene Expression Data.
Bioinformatics and biology insights 2009;1():49-62.
2008: Livia Casciola-Rosen; Alexei Miagkov; K Nagaraju; Frederic B Askin; Lisa P Jacobson; Antony Rosen; Daniel B Drachman
Granzyme B: evidence for a role in the origin of myasthenia gravis.
Journal of neuroimmunology 2008;201-202():33-40.
2008: Michelle Harris-Love; Erika Darrah; Gordon K Lam; Susan J Bartlett; Jon T Giles; Audrey V Grant; Peisong Gao; WILLIAM SCOTT; Hani El-Gabalawy; Livia Casciola-Rosen; Kathleen C Barnes; Joan M Bathon; Antony Rosen
Association of autoimmunity to peptidyl arginine deiminase type 4 with genotype and disease severity in rheumatoid arthritis.
Arthritis and rheumatism 2008;58(7):1958-67.
2008: Francesco Boin; Umberto De Fanis; Susan J Bartlett; Fredrick M Wigley; Antony Rosen; Vincenzo Casolaro
T cell polarization identifies distinct clinical phenotypes in scleroderma lung disease.
Arthritis and rheumatism 2008;58(4):1165-74.
2008: Tomeka L Suber; Livia Casciola-Rosen; Antony Rosen
Mechanisms of disease: autoantigens as clues to the pathogenesis of myositis.
Nature clinical practice. Rheumatology 2008;4(4):201-9.
2008: Chris Cheadle; Maria Nesterova; Tonya Watkins; Kathleen C Barnes; John C Hall; Antony Rosen; Kevin G Becker; Yoon S Cho-Chung
Regulatory subunits of PKA define an axis of cellular proliferation/differentiation in ovarian cancer cells.
BMC medical genomics 2008;1():43.
2007: Mary Jo Mulligan-Kehoe; Mary Drinane; Jessica Mollmark; Livia Casciola-Rosen; Laura K Hummers; Amy Hall; Antony Rosen; Fredrick M Wigley; Michael Simons
Antiangiogenic plasma activity in patients with systemic sclerosis.
Arthritis and rheumatism 2007;56(10):3448-58.
2007: Stuart M Levine; Nina Raben; Dan Xie; Frederic B Askin; Rubin M Tuder; Marissa Mullins; Antony Rosen; Livia Casciola-Rosen
Novel conformation of histidyl-transfer RNA synthetase in the lung: the target tissue in Jo-1 autoantibody-associated myositis.
Arthritis and rheumatism 2007;56(8):2729-39.
2007: Francesco Boin; Antony Rosen
Autoimmunity in systemic sclerosis: current concepts.
Current rheumatology reports 2007;9(2):165-72.
2007: Felipe Andrade; Edward Fellows; Dieter E Jenne; Antony Rosen; C S H Young
Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition.
The EMBO journal 2007;26(8):2148-57.
2007: Livia Casciola-Rosen; Margarita Garcia-Calvo; Herbert G Bull; Joseph W Becker; Tonie Hines; Nancy A Thornberry; Antony Rosen
Mouse and human granzyme B have distinct tetrapeptide specificities and abilities to recruit the bid pathway.
The Journal of biological chemistry 2007;282(7):4545-52.
2007: Thomas Grader-Beck; Livia Casciola-Rosen; Thomas J Lang; Roman Puliaev; Antony Rosen; Charles S Via
Apoptotic splenocytes drive the autoimmune response to poly(ADP-ribose) polymerase 1 in a murine model of lupus.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(1):95-102.
2006: Antony Rosen; Livia Casciola-Rosen
Stem cells in inflammatory disease.
Current opinion in rheumatology 2006;18(6):618-9.
2006: Sarah Spinette; James A Mahoney; Antony Rosen
The MPAC domain is a novel mitotically regulated domain, removed by apoptotic protease cleavage during cell death.
Biochemical and biophysical research communications 2006;347(4):1103-12.
2006: Allan C Gelber; Stanley R Pillemer; B J Baum; Fredrick M Wigley; Laura K Hummers; Steven Morris; Antony Rosen; Livia Casciola-Rosen
Distinct recognition of antibodies to centromere proteins in primary Sjogren's syndrome compared with limited scleroderma.
Annals of the rheumatic diseases 2006;65(8):1028-32.
2006: TONGGUANG WANG; Rameeza Allie; Katherine Conant; Norman Haughey; Jadwiga Turchan-Chelowo; Katrin Hahn; Antony Rosen; Joseph P Steiner; Sanjay C Keswani; Melina Jones; Peter A Calabresi; Avindra Nath
Granzyme B mediates neurotoxicity through a G-protein-coupled receptor.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(8):1209-11.
2006: Rebecca Lamason; Po Zhao; Rashmi Rawat; Adrian Davis; John C Hall; Jae Jin Chae; Rajeev Agarwal; Phillip Cohen; Antony Rosen; Eric Hoffman; Kanneboyina Nagaraju
Sexual dimorphism in immune response genes as a function of puberty.
BMC immunology 2006;7():2.
2005: Francesco Boin; Fredrick M Wigley; Jonathan P Schneck; Mathias Oelke; Antony Rosen
Evaluation of topoisomerase-1-specific CD8+ T-cell response in systemic sclerosis.
Annals of the New York Academy of Sciences 2005;1062():137-45.
2005: Wei D Duan-Porter; Livia Casciola-Rosen; Antony Rosen
Autoantigens: the critical partner in initiating and propagating systemic autoimmunity.
Annals of the New York Academy of Sciences 2005;1062():127-36.
2005: James A Mahoney; Antony Rosen
Apoptosis and autoimmunity.
Current opinion in immunology 2005;17(6):583-8.
2005: Kanneboyina Nagaraju; Livia Casciola-Rosen; Ingrid Lundberg; Rashmi Rawat; Shawna Cutting; Rachana Thapliyal; Jason Chang; Sunita Dwivedi; Megan Mitsak; Yi-Wen Chen; Paul H Plotz; Antony Rosen; Eric Hoffman; Nina Raben
Activation of the endoplasmic reticulum stress response in autoimmune myositis: potential role in muscle fiber damage and dysfunction.
Arthritis and rheumatism 2005;52(6):1824-35.
2005: Rebecca S Maag; Marie Mancini; Antony Rosen; Carolyn E Machamer
Caspase-resistant Golgin-160 disrupts apoptosis induced by secretory pathway stress and ligation of death receptors.
Molecular biology of the cell 2005;16(6):3019-27.
2005: Felipe Andrade; Livia Casciola-Rosen; Antony Rosen
Generation of novel covalent RNA-protein complexes in cells by ultraviolet B irradiation: implications for autoimmunity.
Arthritis and rheumatism 2005;52(4):1160-70.
2005: Livia Casciola-Rosen; Kanneboyina Nagaraju; Paul H Plotz; Kondi Wang; Stuart M Levine; Edward Gabrielson; Andrea M Corse; Antony Rosen
Enhanced autoantigen expression in regenerating muscle cells in idiopathic inflammatory myopathy.
The Journal of experimental medicine 2005;201(4):591-601.
2004: Sarah Spinette; Christoph Lengauer; James A Mahoney; Prasad V Jallepalli; Zhenghe Wang; Livia Casciola-Rosen; Antony Rosen
Ufd2, a novel autoantigen in scleroderma, regulates sister chromatid separation.
Cell cycle (Georgetown, Tex.) 2004;3(12):1638-44.
2004: John C Hall; Livia Casciola-Rosen; Antony Rosen
Altered structure of autoantigens during apoptosis.
Rheumatic diseases clinics of North America 2004;30(3):455-71, vii.
2004: Stanley R Pillemer; Livia Casciola-Rosen; Bruce J Baum; Antony Rosen; Allan C Gelber
Centromere protein C is a target of autoantibodies in Sjögren's syndrome and is uniformly associated with antibodies to Ro and La.
The Journal of rheumatology 2004;31(6):1121-5.
2004: Laura K Hummers; Chitra Krishnan; Livia Casciola-Rosen; Antony Rosen; Steven Morris; James A Mahoney; Douglas A Kerr; Fredrick M Wigley
Recurrent transverse myelitis associates with anti-Ro (SSA) autoantibodies.
Neurology 2004;62(1):147-9.
2004: Kathryn M Roberts; Antony Rosen; Livia Casciola-Rosen
Methods for inducing apoptosis.
Methods in molecular medicine 2004;102():115-28.
2004: Antony Rosen; Livia Casciola-Rosen
Altered autoantigen structure in Sjögren's syndrome: implications for the pathogenesis of autoimmune tissue damage.
Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists 2004;15(3):156-64.
2004: Danielle B Ulanet; Nicholas Flavahan; Livia Casciola-Rosen; Antony Rosen
Selective cleavage of nucleolar autoantigen B23 by granzyme B in differentiated vascular smooth muscle cells: insights into the association of specific autoantibodies with distinct disease phenotypes.
Arthritis and rheumatism 2004;50(1):233-41.
2004: Felipe Andrade; Livia Casciola-Rosen; Antony Rosen
Granzyme B-induced cell death.
Acta haematologica 2004;111(1-2):28-41.
2003: Michelle Harris-Love; Antony Rosen
Autoimmunity in scleroderma: the origin, pathogenetic role, and clinical significance of autoantibodies.
Current opinion in rheumatology 2003;15(6):778-84.
2003: Stuart M Levine; Antony Rosen; Livia Casciola-Rosen
Anti-aminoacyl tRNA synthetase immune responses: insights into the pathogenesis of the idiopathic inflammatory myopathies.
Current opinion in rheumatology 2003;15(6):708-13.
2003: Danielle B Ulanet; Michael Torbenson; Chi Dang; Livia Casciola-Rosen; Antony Rosen
Unique conformation of cancer autoantigen B23 in hepatoma: a mechanism for specificity in the autoimmune response.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(21):12361-6.
2003: Sarah White; Antony Rosen
Apoptosis in systemic lupus erythematosus.
Current opinion in rheumatology 2003;15(5):557-62.
2003: Felipe Andrade; Livia Casciola-Rosen; Antony Rosen
A novel domain in adenovirus L4-100K is required for stable binding and efficient inhibition of human granzyme B: possible interaction with a species-specific exosite.
Molecular and cellular biology 2003;23(17):6315-26.
2003: Danielle B Ulanet; Fredrick M Wigley; Allan C Gelber; Antony Rosen
Autoantibodies against B23, a nucleolar phosphoprotein, occur in scleroderma and are associated with pulmonary hypertension.
Arthritis and rheumatism 2003;49(1):85-92.
2002: O M Zack Howard; Hui Fang Dong; De Yang; Nina Raben; Kanneboyina Nagaraju; Antony Rosen; Livia Casciola-Rosen; Michael Härtlein; Michael A Kron; David Yang; Kwabena P A B Yiadom; Sunita Dwivedi; Paul H Plotz; Joost J Oppenheim
Histidyl-tRNA synthetase and asparaginyl-tRNA synthetase, autoantigens in myositis, activate chemokine receptors on T lymphocytes and immature dendritic cells.
The Journal of experimental medicine 2002;196(6):781-91.
2002: Lionel Schachna; Fredrick M Wigley; Steven Morris; Allan C Gelber; Antony Rosen; Livia Casciola-Rosen
Recognition of Granzyme B-generated autoantigen fragments in scleroderma patients with ischemic digital loss.
Arthritis and rheumatism 2002;46(7):1873-84.
2002: James A Mahoney; Joseph A Odin; Sarah M White; David Shaffer; Andrew Koff; Livia Casciola-Rosen; Antony Rosen
The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis.
The Biochemical journal 2002;361(Pt 3):587-95.
2002: Robert Lance Wells; Yuan Gao; James A Mahoney; Keith Vosseller; Chen Chen; Antony Rosen; Gerald W Hart
Dynamic O-glycosylation of nuclear and cytosolic proteins: further characterization of the nucleocytoplasmic beta-N-acetylglucosaminidase, O-GlcNAcase.
The Journal of biological chemistry 2002;277(3):1755-61.
2001: Kanneboyina Nagaraju; A Cox; Livia Casciola-Rosen; Antony Rosen
Novel fragments of the Sjögren's syndrome autoantigens alpha-fodrin and type 3 muscarinic acetylcholine receptor generated during cytotoxic lymphocyte granule-induced cell death.
Arthritis and rheumatism 2001;44(10):2376-86.
2001: Joseph A Odin; R C Huebert; Livia Casciola-Rosen; Nicholas F LaRusso; Antony Rosen
Bcl-2-dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis.
The Journal of clinical investigation 2001;108(2):223-32.
2001: Felipe Andrade; Herbert G Bull; Nancy A Thornberry; Gary Ketner; Livia Casciola-Rosen; Antony Rosen
Adenovirus L4-100K assembly protein is a granzyme B substrate that potently inhibits granzyme B-mediated cell death.
Immunity 2001;14(6):751-61.
2001: Antony Rosen; Livia Casciola-Rosen
Clearing the way to mechanisms of autoimmunity.
Nature medicine 2001;7(6):664-5.
2001: Livia Casciola-Rosen; A F Pluta; Paul H Plotz; A E Cox; Steven Morris; Fredrick M Wigley; Michelle Petri; Allan C Gelber; Antony Rosen
The DNA mismatch repair enzyme PMS1 is a myositis-specific autoantigen.
Arthritis and rheumatism 2001;44(2):389-96.
2001: Paul H Plotz; F Miller; Eric Hoffman; Livia Casciola-Rosen; Antony Rosen
Workshop on inflammatory myopathy Bethesda, 5-6 April 2000.
Neuromuscular disorders : NMD 2001;11(1):93-5.
2000: Kanneboyina Nagaraju; Livia Casciola-Rosen; Antony Rosen; Craig Thompson; LA Loeffler; T Parker; Carol L Danning; P J Rochon; J Gillespie; Paul H Plotz
The inhibition of apoptosis in myositis and in normal muscle cells.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(10):5459-65.
2000: M Mancini; Carolyn E Machamer; S Roy; Donald W Nicholson; Nancy A Thornberry; Livia Casciola-Rosen; Antony Rosen
Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis.
The Journal of cell biology 2000;149(3):603-12.
2000: Felipe Andrade; Livia Casciola-Rosen; Antony Rosen
Apoptosis in systemic lupus erythematosus. Clinical implications.
Rheumatic diseases clinics of North America 2000;26(2):215-27, v.
2000: Eric L Greidinger; Livia Casciola-Rosen; S M Morris; Robert W Hoffman; Antony Rosen
Autoantibody recognition of distinctly modified forms of the U1-70-kd antigen is associated with different clinical disease manifestations.
Arthritis and rheumatism 2000;43(4):881-8.
2000: S R Dillon; M Mancini; Antony Rosen; Mark S Schlissel
Annexin V binds to viable B cells and colocalizes with a marker of lipid rafts upon B cell receptor activation.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(3):1322-32.
2000: Raphaela Goldbach-Mansky; J Lee; A McCoy; Joseph Hoxworth; Cheryl H Yarboro; J S Smolen; G Steiner; Antony Rosen; C Zhang; Henri-A Ménard; Zhijie J Zhou; T Palosuo; Walther J van Venrooij; Ronald L Wilder; JOHN KLIPPEL; H Ralph Schumacher; Hani El-Gabalawy
Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset.
Arthritis research 2000;2(3):236-43.
1999: Livia Casciola-Rosen; Felipe Andrade; Danielle B Ulanet; BANG WONG; Antony Rosen
Cleavage by granzyme B is strongly predictive of autoantigen status: implications for initiation of autoimmunity.
The Journal of experimental medicine 1999;190(6):815-26.
1999: Steven Xanthoudakis; Sophie Roy; Dita M Rasper; T Hennessey; Yves Aubin; Robin Cassady-Cain; Paul Tawa; R Ruel; Antony Rosen; Donald W Nicholson
Hsp60 accelerates the maturation of pro-caspase-3 by upstream activator proteases during apoptosis.
The EMBO journal 1999;18(8):2049-56.
1999: Antony Rosen; Livia Casciola-Rosen
Autoantigens as substrates for apoptotic proteases: implications for the pathogenesis of systemic autoimmune disease.
Cell death and differentiation 1999;6(1):6-12.
1998: RM Rai; FY Lee; Antony Rosen; Shi Qi Yang; HZ Lin; Ayman Koteish; F Y Liew; Carlos Zaragoza; Charles J Lowenstein; Anna Mae Diehl
Impaired liver regeneration in inducible nitric oxide synthasedeficient mice.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(23):13829-34.
1998: Eric L Greidinger; K T Flaherty; Barbara A White; Antony Rosen; Fredrick M Wigley; Robert Wise
African-American race and antibodies to topoisomerase I are associated with increased severity of scleroderma lung disease.
Chest 1998;114(3):801-7.
1998: Felipe Andrade; S Roy; D Nicholson; Nancy A Thornberry; Antony Rosen; Livia Casciola-Rosen
Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis.
Immunity 1998;8(4):451-60.
1998: M Mancini; Donald W Nicholson; S Roy; Nancy A Thornberry; EP Peterson; Livia Casciola-Rosen; Antony Rosen
The caspase-3 precursor has a cytosolic and mitochondrial distribution: implications for apoptotic signaling.
The Journal of cell biology 1998;140(6):1485-95.
1998: D M Sanghavi; M Thelen; Nancy A Thornberry; Livia Casciola-Rosen; Antony Rosen
Caspase-mediated proteolysis during apoptosis: insights from apoptotic neutrophils.
FEBS letters 1998;422(2):179-84.
1998: Victor E Nava; Antony Rosen; MA Veliuona; RJ Clem; Beth Levine; J Marie Hardwick
Sindbis virus induces apoptosis through a caspase-dependent, CrmA-sensitive pathway.
Journal of virology 1998;72(1):452-9.
1997: Antony Rosen; Livia Casciola-Rosen; Fredrick M Wigley
Role of metal-catalyzed oxidation reactions in the early pathogenesis of scleroderma.
Current opinion in rheumatology 1997;9(6):538-43.
1997: Livia Casciola-Rosen; Fredrick M Wigley; Antony Rosen
Scleroderma autoantigens are uniquely fragmented by metal-catalyzed oxidation reactions: implications for pathogenesis.
The Journal of experimental medicine 1997;185(1):71-9.
1997: Nancy A Thornberry; Antony Rosen; Donald W Nicholson
Control of apoptosis by proteases.
Advances in pharmacology (San Diego, Calif.) 1997;41():155-77.
1997: Livia Casciola-Rosen; Antony Rosen
Ultraviolet light-induced keratinocyte apoptosis: a potential mechanism for the induction of skin lesions and autoantibody production in LE.
Lupus 1997;6(2):175-80.
1997: Antony Rosen; Livia Casciola-Rosen
Macromolecular substrates for the ICE-like proteases during apoptosis.
Journal of cellular biochemistry 1997;64(1):50-4.
1996: Antony Rosen
Huntingtin: new marker along the road to death?
Nature genetics 1996;13(4):380-2.
1996: Eric L Greidinger; D K Miller; T T Yamin; Livia Casciola-Rosen; Antony Rosen
Sequential activation of three distinct ICE-like activities in Fas-ligated Jurkat cells.
FEBS letters 1996;390(3):299-303.
1996: Livia Casciola-Rosen; Donald W Nicholson; T Chong; K R Rowan; Nancy A Thornberry; D K Miller; Antony Rosen
Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death.
The Journal of experimental medicine 1996;183(5):1957-64.
1996: Livia Casciola-Rosen; Antony Rosen; Michelle Petri; M Schlissel
Surface blebs on apoptotic cells are sites of enhanced procoagulant activity: implications for coagulation events and antigenic spread in systemic lupus erythematosus.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(4):1624-9.
1995: Livia Casciola-Rosen; Grant J Anhalt; Antony Rosen
DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis.
The Journal of experimental medicine 1995;182(6):1625-34.
1995: Antony Rosen; Livia Casciola-Rosen; Joseph M Ahearn
Novel packages of viral and self-antigens are generated during apoptosis.
The Journal of experimental medicine 1995;181(4):1557-61.
1994: Livia Casciola-Rosen; D K Miller; Grant J Anhalt; Antony Rosen
Specific cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death.
The Journal of biological chemistry 1994;269(49):30757-60.
1994: Livia Casciola-Rosen; Grant J Anhalt; Antony Rosen
Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes.
The Journal of experimental medicine 1994;179(4):1317-30.