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Jeffrey Rosen

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Li Zhang; Boyu Zhang; Francesco J DeMayo; Sang Jun Han; Jeffrey M Rosen; Amy N Shore; Li Xin
Targeting CreER(T2) expression to keratin 8-expressing murine simple epithelia using bacterial artificial chromosome transgenesis.
Jeffrey M Rosen
On murine mammary epithelial stem cells: discovery, function, and current status.
Fariba Behbod; Jeffrey M Rosen
Mammary gland development & breast cancer; connecting the dots by non-coding RNAs.

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2012: Li Zhang; Boyu Zhang; Francesco J DeMayo; Sang Jun Han; Jeffrey M Rosen; Amy N Shore; Li Xin
Targeting CreER(T2) expression to keratin 8-expressing murine simple epithelia using bacterial artificial chromosome transgenesis.
Transgenic research 2012;21(5):1117-23.
2012: Jeffrey M Rosen
On murine mammary epithelial stem cells: discovery, function, and current status.
Cold Spring Harbor perspectives in biology 2012;4(4):a013268.
2012: Fariba Behbod; Jeffrey M Rosen
Mammary gland development & breast cancer; connecting the dots by non-coding RNAs.
Journal of mammary gland biology and neoplasia 2012;17(1):1-2.
2012: Amy N Shore; Jason I Herschkowitz; Jeffrey M Rosen
Noncoding RNAs involved in mammary gland development and tumorigenesis: there's a long way to go.
Journal of mammary gland biology and neoplasia 2012;17(1):43-58.
2012: Jason I Herschkowitz; Susan G Hilsenbeck; Jana Knezevic; Daniel Medina; George Murrow; Charles M Perou; Melissa A Troester; Jerry Usary; Mei Zhang; Wei Zhao; David Darr; David Edwards; Stephanie B Greene; Jeffrey M Rosen
Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(8):2778-83.
2012: Amy N Shore; Martin A Smith; Yiqun Zhang; Chad J Creighton; Marcel E Dinger; Elena B Kabotyanski; Kevin Roarty; Jeffrey M Rosen
Pregnancy-induced noncoding RNA (PINC) associates with polycomb repressive complex 2 and regulates mammary epithelial differentiation.
PLoS genetics 2012;8(7):e1002840.
2012: Payam Shahi; Julienne L Carstens; Shin-Heng Chiou; Kyucheol Cho; William K Decker; Michael M Ittmann; Pierre D McCrea; Dongsu Park; Adam C Pond; Jeffrey M Rosen; Mamatha R Seethammagari; David M Spencer
Activation of Wnt signaling by chemically induced dimerization of LRP5 disrupts cellular homeostasis.
PloS one 2012;7(1):e30814.
2011: B M Heckman-Stoddard; M P Herrick; Michael Lewis; Jeffrey Settleman; Tracy Vargo-Gogola; A P Visbal; Jeffrey M Rosen
P190A RhoGAP is required for mammary gland development.
Developmental biology 2011;360(1):1-10.
2011: Nino Rainusso; John Hicks; Ching C Lau; Tsz-Kwong Man; Jianhe J Shen; Lisa L Wang; Alexander Yu; Jeffrey M Rosen
Identification and gene expression profiling of tumor-initiating cells isolated from human osteosarcoma cell lines in an orthotopic mouse model.
Cancer biology & therapy 2011;12(4):278-87.
2011: Adam C Buser; Alison E Obr; Elena B Kabotyanski; Sandra L Grimm; Jeffrey M Rosen; Dean P Edwards
Progesterone receptor directly inhibits β-casein gene transcription in mammary epithelial cells through promoting promoter and enhancer repressive chromatin modifications.
Molecular endocrinology (Baltimore, Md.) 2011;25(6):955-68.
2011: Adriana P Visbal; Heather L. LaMarca; Hugo Villanueva; Michael J Toneff; Yi Li; Jeffrey M Rosen; Michael Lewis
Altered differentiation and paracrine stimulation of mammary epithelial cell proliferation by conditionally activated Smoothened.
Developmental biology 2011;352(1):116-27.
2011: Zhubo Wei; Sirisha Peddibhotla; Han Lin; Xiao Fang; Min Li; Jeffrey M Rosen; Pumin Zhang
Early-onset aging and defective DNA damage response in Cdc14b-deficient mice.
Molecular and cellular biology 2011;31(7):1470-7.
2011: Sirisha Peddibhotla; Zhubo Wei; Rao Papineni; Micheal H Lam; Jeffrey M Rosen; Pumin Zhang
The DNA damage effector Chk1 kinase regulates Cdc14B nucleolar shuttling during cell cycle progression.
Cell cycle (Georgetown, Tex.) 2011;10(4):671-9.
2011: Torey D Batts; Chad J Creighton; Yi Li; Heather L Machado; Yiqun Zhang; Jeffrey M Rosen
Stem cell antigen-1 (sca-1) regulates mammary tumor development and cell migration.
PloS one 2011;6(11):e27841.
2011: Frances S Kittrell; Heather L Lamarca; Daniel Medina; Jeffrey M Rosen; Arnoud Sonnenberg; Wa Xian; Mei Zhang; Martha Z Carletti; Jessica Heestand; Sofia Kerbawy; Fariba Behbod
Prospective isolation and characterization of committed and multipotent progenitors from immortalized mouse mammary epithelial cells with morphogenic potential.
Breast cancer research : BCR 2011;13(2):R41.
2010: Kevin Roarty; Jeffrey M Rosen
Wnt and mammary stem cells: hormones cannot fly wingless.
Current opinion in pharmacology 2010;10(6):643-9.
2010: Rachel L Atkinson; Mei Zhang; Parmeswaran Diagaradjane; Sirisha Peddibhotla; Alejandro Contreras; Susan G Hilsenbeck; Wendy A Woodward; Sunil Krishnan; Jenny C Chang; Jeffrey M Rosen
Thermal enhancement with optically activated gold nanoshells sensitizes breast cancer stem cells to radiation therapy.
Science translational medicine 2010;2(55):55ra79.
2010: Jie Dong; Tammy Tong; Amanda M Reynado; Jeffrey M Rosen; Shixia Huang; Yi Li
Genetic manipulation of individual somatic mammary cells in vivo reveals a master role of STAT5a in inducing alveolar fate commitment and lactogenesis even in the absence of ovarian hormones.
Developmental biology 2010;346(2):196-203.
2010: Stephanie B Greene; Jason I Herschkowitz; Jeffrey M Rosen
Small players with big roles: microRNAs as targets to inhibit breast cancer progression.
Current drug targets 2010;11(9):1059-73.
2010: Joseph H Taube; Jason I Herschkowitz; Kakajan Komurov; Alicia Y Zhou; Supriya Gupta; Jing Yang; Kimberly Hartwell; Tamer T Onder; Piyush B Gupta; Kurt W Evans; Brett G Hollier; Prahlad T Ram; Eric S Lander; Jeffrey M Rosen; Robert A Weinberg; Sendurai A Mani
Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(35):15449-54.
2010: Adam C Pond; Jason I Herschkowitz; Kathryn L Schwertfeger; Bryan E. Welm; Yiqun Zhang; Brian York; Robert Cardiff; Susan Hilsenbeck; Charles M Perou; Chad J Creighton; Richard E Lloyd; Jeffrey M Rosen
Fibroblast growth factor receptor signaling dramatically accelerates tumorigenesis and enhances oncoprotein translation in the mouse mammary tumor virus-Wnt-1 mouse model of breast cancer.
Cancer research 2010;70(12):4868-79.
2010: Chad J Creighton; Jenny C Chang; Jeffrey M Rosen
Epithelial-mesenchymal transition (EMT) in tumor-initiating cells and its clinical implications in breast cancer.
Journal of mammary gland biology and neoplasia 2010;15(2):253-60.
2010: Stephanie B Greene; Jason I Herschkowitz; Jeffrey M Rosen
The ups and downs of miR-205: identifying the roles of miR-205 in mammary gland development and breast cancer.
RNA biology 2010;7(3):300-4.
2010: Heather L LaMarca; Adriana P Visbal; Chad J Creighton; Hao Liu; Yiqun Zhang; Fariba Behbod; Jeffrey M Rosen
CCAAT/enhancer binding protein beta regulates stem cell activity and specifies luminal cell fate in the mammary gland.
Stem cells (Dayton, Ohio) 2010;28(3):535-44.
2010: monique rijnkels; Elena Kabotyanski; Mohamad B Montazer-Torbati; Yegor Vassetzky; Jeffrey M Rosen; C Hue Beauvais; Eve Devinoy
The epigenetic landscape of mammary gland development and functional differentiation.
Journal of mammary gland biology and neoplasia 2010;15(1):85-100.
2010: Mei Zhang; Rachel L Atkinson; Jeffrey M Rosen
Selective targeting of radiation-resistant tumor-initiating cells.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(8):3522-7.
2010: Jay P Reddy; Sirisha Peddibhotla; Wen Bu; Jing Zhao; Svasti Haricharan; Yi-Chieh Nancy Du; Katrina Podsypanina; Jeffrey M Rosen; Larry A Donehower; Yi Li
Defining the ATM-mediated barrier to tumorigenesis in somatic mammary cells following ErbB2 activation.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(8):3728-33.
2010: Stephanie B Greene; Preethi H Gunaratne; Scott M Hammond; Jeffrey M Rosen
A putative role for microRNA-205 in mammary epithelial cell progenitors.
Journal of cell science 2010;123(Pt 4):606-18.
2010: Peter R McHenry; Jeffrey M Rosen; Megan Rybarczyk; James C Sears; Peggy Chang; Lewis A Chodosh; Edward J Gunther; Brandy M Heckman-Stoddard; Matthew P Herrick; Susan G Hilsenbeck; Tracy Vargo-Gogola
P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis.
Breast cancer research : BCR 2010;12(5):R73.
2010: Nathan C Boles; Sirisha Peddibhotla; Alice J Chen; Margaret A Goodell; Jeffrey M Rosen
Chk1 haploinsufficiency results in anemia and defective erythropoiesis.
PloS one 2010;5(1):e8581.
2009: Elena B Kabotyanski; monique rijnkels; Courtneay Freeman-Zadrowski; Adam C Buser; Dean P Edwards; Jeffrey M Rosen
Lactogenic hormonal induction of long distance interactions between beta-casein gene regulatory elements.
The Journal of biological chemistry 2009;284(34):22815-24.
2009: Chad J Creighton; X Li; Melissa Landis; J Michael Dixon; Veronique M Neumeister; Ashley Sjolund; David L Rimm; Helen Wong; Angel Rodriguez; Jason I Herschkowitz; Cheng Fan; Xiaomei Zhang; Xiaping He; Anne Pavlick; M Carolina Gutierrez; Lorna Renshaw; Alexey A Larionov; Dana Faratian; Susan G Hilsenbeck; Charles M Perou; Michael Lewis; Jeffrey M Rosen; Jenny C Chang
Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(33):13820-5.
2009: Sirisha Peddibhotla; Jeffrey M Rosen
Chking and executing cell division to prevent genomic instability.
Cell cycle (Georgetown, Tex.) 2009;8(15):2339-42.
2009: Jeffrey M Rosen; Craig T Jordan
The increasing complexity of the cancer stem cell paradigm.
Science (New York, N.Y.) 2009;324(5935):1670-3.
2009: Sirisha Peddibhotla; Michael H. Lam; Maria Gonzalez-Rimbau; Jeffrey M Rosen
The DNA-damage effector checkpoint kinase 1 is essential for chromosome segregation and cytokinesis.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(13):5159-64.
2009: Fariba Behbod; Frances S Kittrell; Heather LaMarca; David Edwards; Sofia Kerbawy; Jessica C Heestand; Evelin Young; Purna Mukhopadhyay; Hung-Wen Yeh; D Craig Allred; Min Hu; Kornelia Polyak; Jeffrey M Rosen; Daniel Medina
An intraductal human-in-mouse transplantation model mimics the subtypes of ductal carcinoma in situ.
Breast cancer research : BCR 2009;11(5):R66.
2009: Brandy M Heckman-Stoddard; Tracy Vargo-Gogola; Peter R McHenry; Vivian Jiang; Matthew P Herrick; Susan G Hilsenbeck; Jeffrey Settleman; Jeffrey M Rosen
Haploinsufficiency for p190B RhoGAP inhibits MMTV-Neu tumor progression.
Breast cancer research : BCR 2009;11(4):R61.
2008: Mei Zhang; Fariba Behbod; Rachel L Atkinson; Melissa D Landis; Frances S Kittrell; David Edwards; Daniel Medina; Anna Tsimelzon; Susan G Hilsenbeck; Jeffrey E Green; Aleksandra M Michalowska; Jeffrey M Rosen
Identification of tumor-initiating cells in a p53-null mouse model of breast cancer.
Cancer research 2008;68(12):4674-82.
2007: Tracy Vargo-Gogola; Jeffrey M Rosen
Modelling breast cancer: one size does not fit all.
Nature reviews. Cancer 2007;7(9):659-72.
2007: Brandy M Heckman; Geetika Chakravarty; Tracy Vargo-Gogola; Maria Gonzales-Rimbau; Darryl L Hadsell; Adrian V Lee; Jeffrey Settleman; Jeffrey M Rosen
Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development.
Developmental biology 2007;309(1):137-49.
2007: Sudit S Mukhopadhyay; Jeffrey M Rosen
The C-terminal domain of the nuclear factor I-B2 isoform is glycosylated and transactivates the WAP gene in the JEG-3 cells.
Biochemical and biophysical research communications 2007;358(3):770-6.
2007: Wa Xian; Kathryn L Schwertfeger; Jeffrey M Rosen
Distinct roles of fibroblast growth factor receptor 1 and 2 in regulating cell survival and epithelial-mesenchymal transition.
Molecular endocrinology (Baltimore, Md.) 2007;21(4):987-1000.
2007: Mercy S Chen; Wendy A Woodward; Fariba Behbod; Sirisha Peddibhotla; Maria P Alfaro; Thomas Buchholz; Jeffrey M Rosen
Wnt/beta-catenin mediates radiation resistance of Sca1+ progenitors in an immortalized mammary gland cell line.
Journal of cell science 2007;120(Pt 3):468-77.
2007: Wendy A Woodward; Mercy S Chen; Fariba Behbod; Maria P Alfaro; Thomas Buchholz; Jeffrey M Rosen
WNT/beta-catenin mediates radiation resistance of mouse mammary progenitor cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(2):618-23.
2007: Heather L. LaMarca; Jeffrey M Rosen
Estrogen regulation of mammary gland development and breast cancer: amphiregulin takes center stage.
Breast cancer research : BCR 2007;9(4):304.
2007: Adam C Buser; Elizabeth K Gass-Handel; Shannon L Wyszomierski; Wolfgang Doppler; Susan A Leonhardt; Jerome Schaack; Jeffrey M Rosen; Harriet Watkin; Steven M Anderson; Dean P Edwards
Progesterone receptor repression of prolactin/signal transducer and activator of transcription 5-mediated transcription of the beta-casein gene in mammary epithelial cells.
Molecular endocrinology (Baltimore, Md.) 2007;21(1):106-25.
2006: Kathryn L Schwertfeger; Jeffrey M Rosen; Donald A Cohen
Mammary gland macrophages: pleiotropic functions in mammary development.
Journal of mammary gland biology and neoplasia 2006;11(3-4):229-38.
2006: Elena B Kabotyanski; Markus Huetter; Wa Xian; monique rijnkels; Jeffrey M Rosen
Integration of prolactin and glucocorticoid signaling at the beta-casein promoter and enhancer by ordered recruitment of specific transcription factors and chromatin modifiers.
Molecular endocrinology (Baltimore, Md.) 2006;20(10):2355-68.
2006: Nathalie Cella; Alejandro Contreras; Khatri Latha; Jeffrey M Rosen; Ming Zhang
Maspin is physically associated with [beta]1 integrin regulating cell adhesion in mammary epithelial cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(9):1510-2.
2006: Kathryn L Schwertfeger; Wa Xian; Alan M Kaplan; Sandra H Burnett; Donald A Cohen; Jeffrey M Rosen
A critical role for the inflammatory response in a mouse model of preneoplastic progression.
Cancer research 2006;66(11):5676-85.
2006: Tracy Vargo-Gogola; Brandy M Heckman; Edward J Gunther; Lewis A Chodosh; Jeffrey M Rosen
P190-B Rho GTPase-activating protein overexpression disrupts ductal morphogenesis and induces hyperplastic lesions in the developing mammary gland.
Molecular endocrinology (Baltimore, Md.) 2006;20(6):1391-405.
2006: Melanie R Ginger; Amy N Shore; Alejandro Contreras; monique rijnkels; Jonathan Miller; Maria F Gonzalez-Rimbau; Jeffrey M Rosen
A noncoding RNA is a potential marker of cell fate during mammary gland development.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(15):5781-6.
2006: Fariba Behbod; Wa Xian; Chad A Shaw; Susan G Hilsenbeck; Anna Tsimelzon; Jeffrey M Rosen
Transcriptional profiling of mammary gland side population cells.
Stem cells (Dayton, Ohio) 2006;24(4):1065-74.
2006: Mei Zhang; Jeffrey M Rosen
Stem cells in the etiology and treatment of cancer.
Current opinion in genetics & development 2006;16(1):60-4.
2006: Sandra L Grimm; Jeffrey M Rosen
Stop! In the name of transforming growth factor-beta: keeping estrogen receptor-alpha-positive mammary epithelial cells from proliferating.
Breast cancer research : BCR 2006;8(4):106.
2006: Sandra L Grimm; Wen Bu; Mary Ann Longley; Dennis R Roop; Yi Li; Jeffrey M Rosen
Keratin 6 is not essential for mammary gland development.
Breast cancer research : BCR 2006;8(3):R29.
2005: Wa Xian; Kathryn L Schwertfeger; Tracy Vargo-Gogola; Jeffrey M Rosen
Pleiotropic effects of FGFR1 on cell proliferation, survival, and migration in a 3D mammary epithelial cell model.
The Journal of cell biology 2005;171(4):663-73.
2005: Sandra L Grimm; Alejandro Contreras; Mary Helen Barcellos-Hoff; Jeffrey M Rosen
Cell cycle defects contribute to a block in hormone-induced mammary gland proliferation in CCAAT/enhancer-binding protein (C/EBPbeta)-null mice.
The Journal of biological chemistry 2005;280(43):36301-9.
2005: Wendy A Woodward; Mercy S Chen; Fariba Behbod; Jeffrey M Rosen
On mammary stem cells.
Journal of cell science 2005;118(Pt 16):3585-94.
2005: Fariba Behbod; Jeffrey M Rosen
Will cancer stem cells provide new therapeutic targets?
Carcinogenesis 2005;26(4):703-11.
2005: Yi Li; Jeffrey M Rosen
Stem/progenitor cells in mouse mammary gland development and breast cancer.
Journal of mammary gland biology and neoplasia 2005;10(1):17-24.
2004: Michael H. Lam; Jeffrey M Rosen
Chk1 versus Cdc25: chking one's levels of cellular proliferation.
Cell cycle (Georgetown, Tex.) 2004;3(11):1355-7.
2004: Michael H. Lam; Qinghua Liu; Stephen J Elledge; Jeffrey M Rosen
Chk1 is haploinsufficient for multiple functions critical to tumor suppression.
Cancer cell 2004;6(1):45-59.
2003: Yi Li; Bryan E. Welm; Katrina Podsypanina; Shixia Huang; Mario Chamorro; Xiaomei Zhang; Tracey M Rowlands; Mikala Egeblad; Pamela Cowin; Zena Werb; Lee K Tan; Jeffrey M Rosen; Harold Varmus
Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15853-8.
2003: Inmaculada Hernandez; Lisette A Maddison; Yongli Wei; Francesco DeMayo; Tobias Petras; Baolin Li; Jeffrey R Gingrich; Jeffrey M Rosen; Norman M Greenberg
Prostate-specific expression of p53(R172L) differentially regulates p21, Bax, and mdm2 to inhibit prostate cancer progression and prolong survival.
Molecular cancer research : MCR 2003;1(14):1036-47.
2003: Kevin W Freeman; Bryan E. Welm; Rama D Gangula; Jeffrey M Rosen; Michael Ittmann; Norman M Greenberg; David M Spencer
Inducible prostate intraepithelial neoplasia with reversible hyperplasia in conditional FGFR1-expressing mice.
Cancer research 2003;63(23):8256-63.
2003: Alejandro Contreras; Tracy K Hale; David L Stenoien; Jeffrey M Rosen; Michael A Mancini; Rafael E Herrera
The dynamic mobility of histone H1 is regulated by cyclin/CDK phosphorylation.
Molecular and cellular biology 2003;23(23):8626-36.
2003: Kevin W Freeman; Rama D Gangula; Bryan E. Welm; Mustafa Ozen; Barbara A Foster; Jeffrey M Rosen; Michael Ittmann; Norman M Greenberg; David M Spencer
Conditional activation of fibroblast growth factor receptor (FGFR) 1, but not FGFR2, in prostate cancer cells leads to increased osteopontin induction, extracellular signal-regulated kinase activation, and in vivo proliferation.
Cancer research 2003;63(19):6237-43.
2003: Bryan E. Welm; Fariba Behbod; Margaret A Goodell; Jeffrey M Rosen
Isolation and characterization of functional mammary gland stem cells.
Cell proliferation 2003;36 Suppl 1():17-32.
2003: monique rijnkels; Laura Elnitski; Webb Miller; Jeffrey M Rosen
Multispecies comparative analysis of a mammalian-specific genomic domain encoding secretory proteins.
Genomics 2003;82(4):417-32.
2003: Jeffrey M Rosen
Striking it rich by data mining.
Cell 2003;114(3):271-2.
2003: Adrian V Lee; P Zhang; Margarita Ivanova; Sharon Bonnette; Steffi Oesterreich; Jeffrey M Rosen; Sandra L Grimm; Russell C Hovey; Barbara K Vonderhaar; C R Kahn; Daniel Torres; Jessy George; Syed K Mohsin; D Craig Allred; Darryl L Hadsell
Developmental and hormonal signals dramatically alter the localization and abundance of insulin receptor substrate proteins in the mammary gland.
Endocrinology 2003;144(6):2683-94.
2003: Geetika Chakravarty; Darryl L Hadsell; William Buitrago; Jeffrey Settleman; Jeffrey M Rosen
p190-B RhoGAP regulates mammary ductal morphogenesis.
Molecular endocrinology (Baltimore, Md.) 2003;17(6):1054-65.
2003: Elena B Kabotyanski; Jeffrey M Rosen
Signal transduction pathways regulated by prolactin and Src result in different conformations of activated Stat5b.
The Journal of biological chemistry 2003;278(19):17218-27.
2003: Sandra L Grimm; Jeffrey M Rosen
The role of C/EBPbeta in mammary gland development and breast cancer.
Journal of mammary gland biology and neoplasia 2003;8(2):191-204.
2003: Jeffrey M Rosen
Transcription factors.
Journal of mammary gland biology and neoplasia 2003;8(2):143-4.
2003: Mary E Pownall; Bryan E. Welm; Kevin W Freeman; David M Spencer; Jeffrey M Rosen; Harry V Isaacs
An inducible system for the study of FGF signalling in early amphibian development.
Developmental biology 2003;256(1):89-99.
2003: Stacey B Tepera; Pierre D McCrea; Jeffrey M Rosen
A beta-catenin survival signal is required for normal lobular development in the mammary gland.
Journal of cell science 2003;116(Pt 6):1137-49.
2003: Daniel Medina; Frances S Kittrell; Anne Shepard; Alejandro Contreras; Jeffrey M Rosen; John Lydon
Hormone dependence in premalignant mammary progression.
Cancer research 2003;63(5):1067-72.
2003: Jeffrey M Rosen
Hormone receptor patterning plays a critical role in normal lobuloalveolar development and breast cancer progression.
Breast disease 2003;18():3-9.
2003: Melanie R Ginger; Jeffrey M Rosen
Pregnancy-induced changes in cell-fate in the mammary gland.
Breast cancer research : BCR 2003;5(4):192-7.
2002: Sandra L Grimm; Tiffany N. Seagroves; Elena B Kabotyanski; Russell C Hovey; Barbara K Vonderhaar; John P Lydon; Keiko Miyoshi; Lothar Hennighausen; Christopher J Ormandy; Adrian V Lee; Malinda A Stull; Teresa L Wood; Jeffrey M Rosen
Disruption of steroid and prolactin receptor patterning in the mammary gland correlates with a block in lobuloalveolar development.
Molecular endocrinology (Baltimore, Md.) 2002;16(12):2675-91.
2002: Michelle Kingsley-Kallesen; Sudit S Mukhopadhyay; Shannon L Wyszomierski; Susan Schanler; Günther Schütz; Jeffrey M Rosen
The mineralocorticoid receptor may compensate for the loss of the glucocorticoid receptor at specific stages of mammary gland development.
Molecular endocrinology (Baltimore, Md.) 2002;16(9):2008-18.
2002: Bryan E. Welm; Kevin W Freeman; Mercy Chen; Alejandro Contreras; David M Spencer; Jeffrey M Rosen
Inducible dimerization of FGFR1: development of a mouse model to analyze progressive transformation of the mammary gland.
The Journal of cell biology 2002;157(4):703-14.
2002: Bryan E. Welm; Stacey B Tepera; Teresa A Venezia; Timothy A Graubert; Jeffrey M Rosen; Margaret A Goodell
Sca-1(pos) cells in the mouse mammary gland represent an enriched progenitor cell population.
Developmental biology 2002;245(1):42-56.
2001: Melanie R Ginger; M F Gonzalez-Rimbau; J P Gay; Jeffrey M Rosen
Persistent changes in gene expression induced by estrogen and progesterone in the rat mammary gland.
Molecular endocrinology (Baltimore, Md.) 2001;15(11):1993-2009.
2001: Sudit S Mukhopadhyay; Shannon L Wyszomierski; Richard M Gronostajski; Jeffrey M Rosen
Differential interactions of specific nuclear factor I isoforms with the glucocorticoid receptor and STAT5 in the cooperative regulation of WAP gene transcription.
Molecular and cellular biology 2001;21(20):6859-69.
2001: monique rijnkels; Jeffrey M Rosen
Adenovirus-Cre-mediated recombination in mammary epithelial early progenitor cells.
Journal of cell science 2001;114(Pt 17):3147-53.
2001: Shannon L Wyszomierski; Jeffrey M Rosen
Cooperative effects of STAT5 (signal transducer and activator of transcription 5) and C/EBPbeta (CCAAT/enhancer-binding protein-beta) on beta-casein gene transcription are mediated by the glucocorticoid receptor.
Molecular endocrinology (Baltimore, Md.) 2001;15(2):228-40.
2001: Alexander V Kazansky; Jeffrey M Rosen
Signal transducers and activators of transcription 5B potentiates v-Src-mediated transformation of NIH-3T3 cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2001;12(1):1-7.
2001: Cynthia A Zahnow; Robert Cardiff; Rodolfo Laucirica; Daniel Medina; Jeffrey M Rosen
A role for CCAAT/enhancer binding protein beta-liver-enriched inhibitory protein in mammary epithelial cell proliferation.
Cancer research 2001;61(1):261-9.
2000: KL Murphy; A P Dennis; Jeffrey M Rosen
A gain of function p53 mutant promotes both genomic instability and cell survival in a novel p53-null mammary epithelial cell model.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(14):2291-302.
2000: Geetika Chakravarty; D Roy; M Gonzales; Jason Gay; A Contreras; Jeffrey M Rosen
P190-B, a Rho-GTPase-activating protein, is differentially expressed in terminal end buds and breast cancer.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 2000;11(7):343-54.
2000: Tiffany N. Seagroves; John P Lydon; Russell C Hovey; Barbara K Vonderhaar; Jeffrey M Rosen
C/EBPbeta (CCAAT/enhancer binding protein) controls cell fate determination during mammary gland development.
Molecular endocrinology (Baltimore, Md.) 2000;14(3):359-68.
2000: KL Murphy; Jeffrey M Rosen
Mutant p53 and genomic instability in a transgenic mouse model of breast cancer.
Oncogene 2000;19(8):1045-51.
2000: Darryl L Hadsell; KL Murphy; Sharon Bonnette; N Reece; Rodolfo Laucirica; Jeffrey M Rosen
Cooperative interaction between mutant p53 and des(1-3)IGF-I accelerates mammary tumorigenesis.
Oncogene 2000;19(7):889-98.
1999: KL Murphy; Frances S Kittrell; Jason Gay; richard jäger; Daniel Medina; Jeffrey M Rosen
Bcl-2 expression delays mammary tumor development in dimethylbenz(a)anthracene-treated transgenic mice.
Oncogene 1999;18(47):6597-604.
1999: Alexander V Kazansky; Elena B Kabotyanski; Shannon L Wyszomierski; Michael A Mancini; Jeffrey M Rosen
Differential effects of prolactin and src/abl kinases on the nuclear translocation of STAT5B and STAT5A.
The Journal of biological chemistry 1999;274(32):22484-92.
1999: Shannon L Wyszomierski; J Yeh; Jeffrey M Rosen
Glucocorticoid receptor/signal transducer and activator of transcription 5 (STAT5) interactions enhance STAT5 activation by prolonging STAT5 DNA binding and tyrosine phosphorylation.
Molecular endocrinology (Baltimore, Md.) 1999;13(2):330-43.
1999: Jeffrey M Rosen; Shannon L Wyszomierski; Darryl L Hadsell
Regulation of milk protein gene expression.
Annual review of nutrition 1999;19():407-36.
1998: Tiffany N. Seagroves; S Krnacik; B Raught; J Gay; BL Burgess-Beusse; Gretchen Darlington; Jeffrey M Rosen
C/EBPbeta, but not C/EBPalpha, is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation in the mouse mammary gland.
Genes & development 1998;12(12):1917-28.
1998: B Li; KL Murphy; Rodolfo Laucirica; Frances S Kittrell; Daniel Medina; Jeffrey M Rosen
A transgenic mouse model for mammary carcinogenesis.
Oncogene 1998;16(8):997-1007.
1998: Jeffrey M Rosen; Cynthia A Zahnow; Alexander V Kazansky; B Raught
Composite response elements mediate hormonal and developmental regulation of milk protein gene expression.
Biochemical Society symposium 1998;63():101-13.
1997: Cynthia A Zahnow; Pamela S Younes; Rodolfo Laucirica; Jeffrey M Rosen
Overexpression of C/EBPbeta-LIP, a naturally occurring, dominant-negative transcription factor, in human breast cancer.
Journal of the National Cancer Institute 1997;89(24):1887-91.
1997: Robin Humphreys; Jeffrey M Rosen
Stably transfected HC11 cells provide an in vitro and in vivo model system for studying Wnt gene function.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997;8(8):839-49.
1997: Robin Humphreys; John P Lydon; Bert W O'Malley; Jeffrey M Rosen
Mammary gland development is mediated by both stromal and epithelial progesterone receptors.
Molecular endocrinology (Baltimore, Md.) 1997;11(6):801-11.
1997: S Yarus; T E Weaver; Jeffrey M Rosen
The carboxy-terminal domain of human surfactant protein B is not required for secretion in milk of transgenic mice.
Frontiers in bioscience : a journal and virtual library 1997;2():a1-8.
1997: S Yarus; N M Greenberg; Y Wei; J A Whitsett; T E Weaver; Jeffrey M Rosen
Secretion of unprocessed human surfactant protein B in milk of transgenic mice.
Transgenic research 1997;6(1):51-7.
1996: S Yarus; Jeffrey M Rosen; A M Cole; Gill Diamond
Production of active bovine tracheal antimicrobial peptide in milk of transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):14118-21.
1996: Brian Raught; Anne-Claude Gingras; A James; Daniel Medina; Nahum Sonenberg; Jeffrey M Rosen
Expression of a translationally regulated, dominant-negative CCAAT/enhancer-binding protein beta isoform and up-regulation of the eukaryotic translation initiation factor 2alpha are correlated with neoplastic transformation of mammary epithelial cells.
Cancer research 1996;56(19):4382-6.
1996: J R Gingrich; Roberto Barrios; Ronald A Morton; B F Boyce; F J DeMayo; M J Finegold; R Angelopoulou; Jeffrey M Rosen; Norman M Greenberg
Metastatic prostate cancer in a transgenic mouse.
Cancer research 1996;56(18):4096-102.
1996: Jeffrey M Rosen; S Li; Brian Raught; D Hadsell
The mammary gland as a bioreactor: factors regulating the efficient expression of milk protein-based transgenes.
The American journal of clinical nutrition 1996;63(4):627S-32S.
1996: S Yarus; D Hadsell; Jeffrey M Rosen
Engineering transgenes for use in the mammary gland.
Genetic engineering 1996;18():57-81.
1996: D L Hadsell; N M Greenberg; J M Fligger; Craig R Baumrucker; Jeffrey M Rosen
Targeted expression of des(1-3) human insulin-like growth factor I in transgenic mice influences mammary gland development and IGF-binding protein expression.
Endocrinology 1996;137(1):321-30.
1995: A V Kazansky; Brian Raught; S M Lindsey; Y F Wang; Jeffrey M Rosen
Regulation of mammary gland factor/Stat5a during mammary gland development.
Molecular endocrinology (Baltimore, Md.) 1995;9(11):1598-609.
1995: B Li; Frances S Kittrell; Daniel Medina; Jeffrey M Rosen
Delay of dimethylbenz[a]anthracene-induced mammary tumorigenesis in transgenic mice by apoptosis induced by an unusual mutant p53 protein.
Molecular carcinogenesis 1995;14(2):75-83.
1995: Brian Raught; Warren S-L Liao; Jeffrey M Rosen
Developmentally and hormonally regulated CCAAT/enhancer-binding protein isoforms influence beta-casein gene expression.
Molecular endocrinology (Baltimore, Md.) 1995;9(9):1223-32.
1995: Y Wei; S Yarus; N M Greenberg; J Whitsett; Jeffrey M Rosen
Production of human surfactant protein C in milk of transgenic mice.
Transgenic research 1995;4(4):232-40.
1995: M J Krnacik; S Li; J Liao; Jeffrey M Rosen
Position-independent expression of whey acidic protein transgenes.
The Journal of biological chemistry 1995;270(19):11119-29.
1995: Norman M Greenberg; F DeMayo; M J Finegold; Daniel Medina; W D Tilley; J O Aspinall; G R Cunha; A A Donjacour; R J Matusik; Jeffrey M Rosen
Prostate cancer in a transgenic mouse.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(8):3439-43.
1995: S Li; Jeffrey M Rosen
Nuclear factor I and mammary gland factor (STAT5) play a critical role in regulating rat whey acidic protein gene expression in transgenic mice.
Molecular and cellular biology 1995;15(4):2063-70.
1994: S Li; Jeffrey M Rosen
Glucocorticoid regulation of rat whey acidic protein gene expression involves hormone-induced alterations of chromatin structure in the distal promoter region.
Molecular endocrinology (Baltimore, Md.) 1994;8(10):1328-35.
1994: B Li; N Greenberg; L C Stephens; R Meyn; Daniel Medina; Jeffrey M Rosen
Preferential overexpression of a 172Arg-->Leu mutant p53 in the mammary gland of transgenic mice results in altered lobuloalveolar development.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994;5(7):711-21.
1994: S Li; Jeffrey M Rosen
Distal regulatory elements required for rat whey acidic protein gene expression in transgenic mice.
The Journal of biological chemistry 1994;269(19):14235-43.
1994: Norman M Greenberg; F J DeMayo; Patricia C Sheppard; Roberto Barrios; RM Lebovitz; Milton Finegold; R Angelopoulou; Janice G Dodd; M L Duckworth; Jeffrey M Rosen
The rat probasin gene promoter directs hormonally and developmentally regulated expression of a heterologous gene specifically to the prostate in transgenic mice.
Molecular endocrinology (Baltimore, Md.) 1994;8(2):230-9.
1994: S Coleman-Krnacik; Jeffrey M Rosen
Differential temporal and spatial gene expression of fibroblast growth factor family members during mouse mammary gland development.
Molecular endocrinology (Baltimore, Md.) 1994;8(2):218-29.
1994: Jeffrey M Rosen; Robin Humphreys; S Krnacik; P Juo; Brian Raught
The regulation of mammary gland development by hormones, growth factors, and oncogenes.
Progress in clinical and biological research 1994;387():95-111.
1993: T A Bühler; T C Dale; C Kieback; Robin Humphreys; Jeffrey M Rosen
Localization and quantification of Wnt-2 gene expression in mouse mammary development.
Developmental biology 1993;155(1):87-96.
1992: J Wolff; Connie Wong; H Cheng; P Poyet; Janet S Butel; Jeffrey M Rosen
Differential effects of the simian virus 40 early genes on mammary epithelial cell growth, morphology, and gene expression.
Experimental cell research 1992;202(1):67-76.
1992: T C Dale; M J Krnacik; C Schmidhauser; C L Yang; M J Bissell; Jeffrey M Rosen
High-level expression of the rat whey acidic protein gene is mediated by elements in the promoter and 3' untranslated region.
Molecular and cellular biology 1992;12(3):905-14.
1991: Norman M Greenberg; J W Anderson; A J Hsueh; K Nishimori; J J Reeves; D M deAvila; D N Ward; Jeffrey M Rosen
Expression of biologically active heterodimeric bovine follicle-stimulating hormone in milk of transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(19):8327-31.
1991: Norman M Greenberg; T V Reding; T Duffy; Jeffrey M Rosen
A heterologous hormone response element enhances expression of rat beta-casein promoter-driven chloramphenicol acetyltransferase fusion genes in the mammary gland of transgenic mice.
Molecular endocrinology (Baltimore, Md.) 1991;5(10):1504-12.
1990: H S Goodman; Jeffrey M Rosen
Transcriptional analysis of the mouse beta-casein gene.
Molecular endocrinology (Baltimore, Md.) 1990;4(11):1661-70.
1990: Evelyn Bayna; Jeffrey M Rosen
Tissue-specific, high level expression of the rat whey acidic protein gene in transgenic mice.
Nucleic acids research 1990;18(10):2977-85.
1989: Jeffrey M Rosen; Evelyn Bayna; K F Lee
Analysis of milk protein gene expression in transgenic mice.
Molecular biology & medicine 1989;6(6):501-9.
1989: P Poyet; Susan J Henning; Jeffrey M Rosen
Hormone-dependent beta-casein mRNA stabilization requires ongoing protein synthesis.
Molecular endocrinology (Baltimore, Md.) 1989;3(12):1961-8.
1989: K F Lee; S H Atiee; Susan J Henning; Jeffrey M Rosen
Relative contribution of promoter and intragenic sequences in the hormonal regulation of rat beta-casein transgenes.
Molecular endocrinology (Baltimore, Md.) 1989;3(3):447-53.
1989: K F Lee; S H Atiee; Jeffrey M Rosen
Differential regulation of rat beta-casein-chloramphenicol acetyltransferase fusion gene expression in transgenic mice.
Molecular and cellular biology 1989;9(2):560-5.
1989: Jeffrey M Rosen; P Poyet; H Goodman; K F Lee
Mechanisms by which prolactin and glucocorticoids regulate casein gene expression.
Biochemical Society symposium 1989;55():115-23.
1988: R S Eisenstein; Jeffrey M Rosen
Both cell substratum regulation and hormonal regulation of milk protein gene expression are exerted primarily at the posttranscriptional level.
Molecular and cellular biology 1988;8(8):3183-90.
1988: S M Campbell; M M Taha; Daniel Medina; Jeffrey M Rosen
A clonal derivative of mammary epithelial cell line COMMA-D retains stem cell characteristics of unique morphological and functional heterogeneity.
Experimental cell research 1988;177(1):109-21.
1988: Li-Yuan Yu-Lee; Jeffrey M Rosen
A transfected alpha-casein minigene bypasses posttranscriptional control by hormones, but retains cell-substratum regulation in mammary epithelial cells.
Molecular endocrinology (Baltimore, Md.) 1988;2(5):431-43.
1988: K F Lee; F J DeMayo; S H Atiee; Jeffrey M Rosen
Tissue-specific expression of the rat beta-casein gene in transgenic mice.
Nucleic acids research 1988;16(3):1027-41.