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Michael Rosen

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Yi-Heng Hao; Da Jia; Saumya Ramanathan; Michael K Rosen; Ming Xu; Daniel D Billadeau; Zhijian J Chen; Jennifer M Doyle; Timothy S Gomez; Patrick Ryan Potts
Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination.
Josep Rizo; Michael K Rosen; Kevin H Gardner
Enlightening molecular mechanisms through study of protein interactions.
Da Jia; Daniel D Billadeau; Timothy Gomez; Michael K Rosen
Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer.

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All Publications

2013: Yi-Heng Hao; Da Jia; Saumya Ramanathan; Michael K Rosen; Ming Xu; Daniel D Billadeau; Zhijian J Chen; Jennifer M Doyle; Timothy S Gomez; Patrick Ryan Potts
Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination.
Cell 2013;152(5):1051-64.
2012: Josep Rizo; Michael K Rosen; Kevin H Gardner
Enlightening molecular mechanisms through study of protein interactions.
Journal of molecular cell biology 2012;4(5):270-83.
2012: Da Jia; Daniel D Billadeau; Timothy Gomez; Michael K Rosen
Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer.
Molecular biology of the cell 2012;23(12):2352-61.
2012: Pilong Li; Marc Llaguno; B Tracy Nixon; Paul S Russo; Salman F Banani; Sudeep Banjade; Baoyu Chen; Hui-Chun Cheng; Liang Guo; Javoris V Hollingsworth; Qiu-Xing Jiang; Soyeon Kim; David S King; Michael K Rosen
Phase transitions in the assembly of multivalent signalling proteins.
Nature 2012;483(7389):336-40.
2011: PiLong Li; Ilídio R S Martins; Michael K Rosen
The feasibility of parameterizing four-state equilibria using relaxation dispersion measurements.
Journal of biomolecular NMR 2011;51(1-2):57-70.
2011: Bingke Yu; Diana R Tomchick; Chad A Brautigam; Hui-Chun Cheng; Michael K Rosen
Mechanism of actin filament nucleation by the bacterial effector VopL.
Nature structural & molecular biology 2011;18(9):1068-74.
2011: Shae B Padrick; Chad A Brautigam; Lynda K Doolittle; David S King; Michael K Rosen
Arp2/3 complex is bound and activated by two WASP proteins.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(33):E472-9.
2010: Shae B Padrick; Ranjit K Deka; Jacinta L Chuang; R Max Wynn; David T Chuang; Michael V Norgard; Michael K Rosen; Chad A Brautigam
Determination of protein complex stoichiometry through multisignal sedimentation velocity experiments.
Analytical biochemistry 2010;407(1):89-103.
2010: Zhucheng Chen; Dominika Borek; Shae B Padrick; Timothy Gomez; Zoltan Metlagel; Ayman M Ismail; Junko Umetani; Daniel D Billadeau; Zbyszek Otwinowski; Michael K Rosen
Structure and control of the actin regulatory WAVE complex.
Nature 2010;468(7323):533-8.
2010: Devin Strickland; Xiaolan Yao; Grzegorz Gawlak; Michael K Rosen; Kevin H Gardner; Tobin R Sosnick
Rationally improving LOV domain-based photoswitches.
Nature methods 2010;7(8):623-6.
2010: Da Jia; Timothy Gomez; Zoltan Metlagel; Junko Umetani; Zbyszek Otwinowski; Michael K Rosen; Daniel D Billadeau
WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(23):10442-7.
2010: Bingke Yu; Ilídio R S Martins; PiLong Li; Gaya K Amarasinghe; Junko Umetani; Martin E Fernandez Zapico; Daniel D Billadeau; Mischa Machius; Diana R Tomchick; Michael K Rosen
Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1.
Cell 2010;140(2):246-56.
2010: Takanori Otomo; Diana R Tomchick; Chinatsu Otomo; Mischa Machius; Michael K Rosen
Crystal structure of the Formin mDia1 in autoinhibited conformation.
PloS one 2010;5(9):.
2010: Shae B Padrick; Michael K Rosen
Physical mechanisms of signal integration by WASP family proteins.
Annual review of biochemistry 2010;79():707-35.
2009: Ayman M Ismail; Shae B Padrick; Baoyu Chen; Junko Umetani; Michael K Rosen
The WAVE regulatory complex is inhibited.
Nature structural & molecular biology 2009;16(5):561-3.
2008: Shae B Padrick; Hui-Chun Cheng; Ayman M Ismail; Sanjay C Panchal; Lynda K Doolittle; Soyeon Kim; Brian M Skehan; Junko Umetani; Chad A Brautigam; John M Leong; Michael K Rosen
Hierarchical regulation of WASP/WAVE proteins.
Molecular cell 2008;32(3):426-38.
2008: Daisy W Leung; Chinatsu Otomo; joanne chory; Michael K Rosen
Genetically encoded photoswitching of actin assembly through the Cdc42-WASP-Arp2/3 complex pathway.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(35):12797-802.
2008: Hui-Chun Cheng; Brian M Skehan; Kenneth G Campellone; John M Leong; Michael K Rosen
Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspF(U).
Nature 2008;454(7207):1009-13.
2008: Xiaolan Yao; Michael K Rosen; Kevin H Gardner
Estimation of the available free energy in a LOV2-J alpha photoswitch.
Nature chemical biology 2008;4(8):491-7.
2008: PiLong Li; Ilídio R S Martins; Gaya K Amarasinghe; Michael K Rosen
Internal dynamics control activation and activity of the autoinhibited Vav DH domain.
Nature structural & molecular biology 2008;15(6):613-8.
2007: Amy D B Liverman; Hui-Chun Cheng; Jennifer E Trosky; Daisy W Leung; Melanie L Yarbrough; Dara L Burdette; Michael K Rosen; Kim Orth
Arp2/3-independent assembly of actin by Vibrio type III effector VopL.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(43):17117-22.
2007: Andrew D Ferguson; Carlos A Amezcua; Najeeb Halabi; Yogarany Chelliah; Michael K Rosen; Rama Ranganathan; Johann Deisenhofer
Signal transduction pathway of TonB-dependent transporters.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(2):513-8.
2006: Abhinav Seth; Chinatsu Otomo; Michael K Rosen
Autoinhibition regulates cellular localization and actin assembly activity of the diaphanous-related formins FRLalpha and mDia1.
The Journal of cell biology 2006;174(5):701-13.
2006: Irina Tskvitaria-Fuller; Abhinav Seth; Neeta Mistry; Hua Gu; Michael K Rosen; Christoph Wülfing
Specific patterns of Cdc42 activity are related to distinct elements of T cell polarization.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(3):1708-20.
2006: Eduardo Torres; Michael K Rosen
Protein-tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich syndrome protein (WASP)/neuronal WASP.
The Journal of biological chemistry 2006;281(6):3513-20.
2006: Daisy W Leung; David M Morgan; Michael K Rosen
Biochemical properties and inhibitors of (N-)WASP.
Methods in enzymology 2006;406():281-96.
2005: Gaya K Amarasinghe; Michael K Rosen
Acidic region tyrosines provide access points for allosteric activation of the autoinhibited Vav1 Dbl homology domain.
Biochemistry 2005;44(46):15257-68.
2005: Mara Kreishman-Deitrick; Erin Goley; Lyle Burdine; Carilee Denison; Coumaran Egile; Rong Li; Nagarajan Murali; Thomas Kodadek; Matt D Welch; Michael K Rosen
NMR analyses of the activation of the Arp2/3 complex by neuronal Wiskott-Aldrich syndrome protein.
Biochemistry 2005;44(46):15247-56.
2005: Tom Shemesh; Takanori Otomo; Michael K Rosen; Alexander D Bershadsky; Michael M Kozlov
A novel mechanism of actin filament processive capping by formin: solution of the rotation paradox.
The Journal of cell biology 2005;170(6):889-93.
2005: Takanori Otomo; Michael K Rosen
[Structure and function of Formin homology 2 domain].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2005;50(9):1088-93.
2005: Takanori Otomo; Chinatsu Otomo; Diana R Tomchick; Mischa Machius; Michael K Rosen
Structural basis of Rho GTPase-mediated activation of the formin mDia1.
Molecular cell 2005;18(3):273-81.
2005: Daisy W Leung; Michael K Rosen
The nucleotide switch in Cdc42 modulates coupling between the GTPase-binding and allosteric equilibria of Wiskott-Aldrich syndrome protein.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(16):5685-90.
2005: Takanori Otomo; Diana R Tomchick; Chinatsu Otomo; Sanjay C Panchal; Mischa Machius; Michael K Rosen
Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain.
Nature 2005;433(7025):488-94.
2004: Jeffrey Peterson; Lincoln C Bickford; David Morgan; Annette S Kim; Ouathek Ouerfelli; Marc W Kirschner; Michael K Rosen
Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation.
Nature structural & molecular biology 2004;11(8):747-55.
2003: Christine M Labno; Carol M Lewis; Daoqi You; Daisy W Leung; Aya Takesono; Natalie Kamberos; Abhinav Seth; Lisa D Finkelstein; Michael K Rosen; Pamela L Schwartzberg; Janis Burkhardt
Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP.
Current biology : CB 2003;13(18):1619-24.
2003: Sanjay C Panchal; Don Kaiser; Eduardo Torres; Thomas D Pollard; Michael K Rosen
A conserved amphipathic helix in WASP/Scar proteins is essential for activation of Arp2/3 complex.
Nature structural biology 2003;10(8):591-8.
2003: Mara Kreishman-Deitrick; Coumaran Egile; David W Hoyt; Joseph J Ford; Rong Li; Michael K Rosen
NMR analysis of methyl groups at 100-500 kDa: model systems and Arp2/3 complex.
Biochemistry 2003;42(28):8579-86.
2003: Eduardo Torres; Michael K Rosen
Contingent phosphorylation/dephosphorylation provides a mechanism of molecular memory in WASP.
Molecular cell 2003;11(5):1215-27.
2003: Abhinav Seth; Takanori Otomo; Helen L Yin; Michael K Rosen
Rational design of genetically encoded fluorescence resonance energy transfer-based sensors of cellular Cdc42 signaling.
Biochemistry 2003;42(14):3997-4008.
2003: Sarah M Garrard; Christopher T Capaldo; Lin Gao; Michael K Rosen; Ian G Macara; Diana R Tomchick
Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6.
The EMBO journal 2003;22(5):1125-33.
2002: Mara Kreishman-Deitrick; Michael K Rosen; Mara Kreishman-Deltrick
Ignition of a cellular machine.
Nature cell biology 2002;4(2):E31-3.
2001: M Buck; Weijun Xu; Michael K Rosen
Global disruption of the WASP autoinhibited structure on Cdc42 binding. Ligand displacement as a novel method for monitoring amide hydrogen exchange.
Biochemistry 2001;40(47):14115-22.
2001: Judy L Cannon; Christine M Labno; G Bosco; A Seth; M H McGavin; K A Siminovitch; Michael K Rosen; Janis Burkhardt
Wasp recruitment to the T cell:APC contact site occurs independently of Cdc42 activation.
Immunity 2001;15(2):249-59.
2001: M Buck; Michael K Rosen
Structural biology. Flipping a switch.
Science (New York, N.Y.) 2001;291(5512):2329-30.
2001: koenraad devriendt; Annette S Kim; G Mathijs; Suzanna G M Frints; M Schwartz; J J Van Den Oord; G E Verhoef; M A Boogaerts; Jean-Pierre Fryns; Daoqi You; Michael K Rosen; Peter Vandenberghe
Constitutively activating mutation in WASP causes X-linked severe congenital neutropenia.
Nature genetics 2001;27(3):313-7.
2000: B Aghazadeh; William Lowry; X Y Huang; Michael K Rosen
Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation.
Cell 2000;102(5):625-33.
2000: A Liu; weidong hu; Ananya Majumdar; Michael K Rosen; Dinshaw J Patel
NMR detection of side chain-side chain hydrogen bonding interactions in 13C/15N-labeled proteins.
Journal of biomolecular NMR 2000;17(4):305-10.
2000: A Liu; weidong hu; Ananya Majumdar; Michael K Rosen; Dinshaw J Patel
Detection of very weak side chain-main chain hydrogen bonding interactions in medium-size 13C/15N-labeled proteins by sensitivity-enhanced NMR spectroscopy.
Journal of biomolecular NMR 2000;17(1):79-82.
2000: Annette S Kim; L T Kakalis; N Abdul-Manan; GA Liu; Michael K Rosen
Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein.
Nature 2000;404(6774):151-8.
1999: B Aghazadeh; Michael K Rosen
Ligand recognition by SH3 and WW domains: the role of N-alkylation in PPII helices.
Chemistry & biology 1999;6(9):R241-6.
1999: N Abdul-Manan; B Aghazadeh; GA Liu; A Majumdar; Ouathek Ouerfelli; K A Siminovitch; Michael K Rosen
Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein.
Nature 1999;399(6734):379-83.
1998: B Aghazadeh; K Zhu; T J Kubiseski; GA Liu; T Pawson; Y Zheng; Michael K Rosen
Structure and mutagenesis of the Dbl homology domain.
Nature structural biology 1998;5(12):1098-107.
1997: Yuying Gosser; TK Nomanbhoy; B Aghazadeh; D Manor; C Combs; Richard A Cerione; Michael K Rosen
C-terminal binding domain of Rho GDP-dissociation inhibitor directs N-terminal inhibitory peptide to GTPases.
Nature 1997;387(6635):814-9.