Michael Rosen

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Ismail Ayman M; Padrick Shae B; Chen Baoyu; Umetani Junko; Rosen Michael K
The WAVE regulatory complex is inhibited.
Padrick Shae B; Cheng Hui-Chun; Ismail Ayman M; Panchal Sanjay C; Doolittle Lynda K; Kim Soyeon; Skehan Brian M; Umetani Junko; Brautigam Chad A; Leong John M; Rosen Michael K
Hierarchical regulation of WASP/WAVE proteins.
Leung Daisy W; Otomo Chinatsu; Chory Joanne; Rosen Michael K
Genetically encoded photoswitching of actin assembly through the Cdc42-WASP-Arp2/3 complex pathway.

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All Publications

2009: Ismail Ayman M; Padrick Shae B; Chen Baoyu; Umetani Junko; Rosen Michael K
The WAVE regulatory complex is inhibited.
Nature structural & molecular biology 2009;16(5):561-3.
2008: Padrick Shae B; Cheng Hui-Chun; Ismail Ayman M; Panchal Sanjay C; Doolittle Lynda K; Kim Soyeon; Skehan Brian M; Umetani Junko; Brautigam Chad A; Leong John M; Rosen Michael K
Hierarchical regulation of WASP/WAVE proteins.
Molecular cell 2008;32(3):426-38.
2008: Leung Daisy W; Otomo Chinatsu; Chory Joanne; Rosen Michael K
Genetically encoded photoswitching of actin assembly through the Cdc42-WASP-Arp2/3 complex pathway.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(35):12797-802.
2008: Cheng Hui-Chun; Skehan Brian M; Campellone Kenneth G; Leong John M; Rosen Michael K
Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspF(U).
Nature 2008;454(7207):1009-13.
2008: Yao Xiaolan; Rosen Michael K; Gardner Kevin H
Estimation of the available free energy in a LOV2-J alpha photoswitch.
Nature chemical biology 2008;4(8):491-7.
2008: Li Pilong; Martins Ilídio R S; Amarasinghe Gaya K; Rosen Michael K
Internal dynamics control activation and activity of the autoinhibited Vav DH domain.
Nature structural & molecular biology 2008;15(6):613-8.
2007: Liverman Amy D B; Cheng Hui-Chun; Trosky Jennifer E; Leung Daisy W; Yarbrough Melanie L; Burdette Dara L; Rosen Michael K; Orth Kim
Arp2/3-independent assembly of actin by Vibrio type III effector VopL.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(43):17117-22.
2007: Ferguson Andrew D; Amezcua Carlos A; Halabi Najeeb M; Chelliah Yogarany; Rosen Michael K; Ranganathan Rama; Deisenhofer Johann
Signal transduction pathway of TonB-dependent transporters.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(2):513-8.
2006: Seth Abhinav; Otomo Chinatsu; Rosen Michael K
Autoinhibition regulates cellular localization and actin assembly activity of the diaphanous-related formins FRLalpha and mDia1.
The Journal of cell biology 2006;174(5):701-13.
2006: Tskvitaria-Fuller Irina; Seth Abhinav; Mistry Neeta; Gu Hua; Rosen Michael K; Wülfing Christoph
Specific patterns of Cdc42 activity are related to distinct elements of T cell polarization.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(3):1708-20.
2006: Torres Eduardo; Rosen Michael K
Protein-tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich syndrome protein (WASP)/neuronal WASP.
The Journal of biological chemistry 2006;281(6):3513-20.
2006: Leung Daisy W; Morgan David M; Rosen Michael K
Biochemical properties and inhibitors of (N-)WASP.
Methods in enzymology 2006;406():281-96.
2005: Amarasinghe Gaya K; Rosen Michael K
Acidic region tyrosines provide access points for allosteric activation of the autoinhibited Vav1 Dbl homology domain.
Biochemistry 2005;44(46):15257-68.
2005: Kreishman-Deitrick Mara; Goley Erin D; Burdine Lyle; Denison Carilee; Egile Coumaran; Li Rong; Murali Nagarajan; Kodadek Thomas J; Welch Matthew D; Rosen Michael K
NMR analyses of the activation of the Arp2/3 complex by neuronal Wiskott-Aldrich syndrome protein.
Biochemistry 2005;44(46):15247-56.
2005: Shemesh Tom; Otomo Takanori; Rosen Michael K; Bershadsky Alexander D; Kozlov Michael M
A novel mechanism of actin filament processive capping by formin: solution of the rotation paradox.
The Journal of cell biology 2005;170(6):889-93.
2005: Otomo Takanori; Rosen Michael K
[Structure and function of Formin homology 2 domain]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2005;50(9):1088-93.
2005: Otomo Takanori; Otomo Chinatsu; Tomchick Diana R; Machius Mischa; Rosen Michael K
Structural basis of Rho GTPase-mediated activation of the formin mDia1.
Molecular cell 2005;18(3):273-81.
2005: Leung Daisy W; Rosen Michael K
The nucleotide switch in Cdc42 modulates coupling between the GTPase-binding and allosteric equilibria of Wiskott-Aldrich syndrome protein.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(16):5685-90.
2005: Otomo Takanori; Tomchick Diana R; Otomo Chinatsu; Panchal Sanjay C; Machius Mischa; Rosen Michael K
Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain.
Nature 2005;433(7025):488-94.
2004: Peterson Jeffrey R; Bickford Lincoln C; Morgan David; Kim Annette S; Ouerfelli Ouathek; Kirschner Marc W; Rosen Michael K
Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation.
Nature structural & molecular biology 2004;11(8):747-55.
2003: Labno Christine M; Lewis Carol M; You Daoqi; Leung Daisy W; Takesono Ana; Kamberos Natalie; Seth Abhinav; Finkelstein Lisa D; Rosen Michael K; Schwartzberg Pamela L; Burkhardt Janis K
Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP.
Current biology : CB 2003;13(18):1619-24.
2003: Panchal Sanjay C; Kaiser Donald A; Torres Eduardo; Pollard Thomas D; Rosen Michael K
A conserved amphipathic helix in WASP/Scar proteins is essential for activation of Arp2/3 complex.
Nature structural biology 2003;10(8):591-8.
2003: Kreishman-Deitrick Mara; Egile Coumaran; Hoyt David W; Ford Joseph J; Li Rong; Rosen Michael K
NMR analysis of methyl groups at 100-500 kDa: model systems and Arp2/3 complex.
Biochemistry 2003;42(28):8579-86.
2003: Torres Eduardo; Rosen Michael K
Contingent phosphorylation/dephosphorylation provides a mechanism of molecular memory in WASP.
Molecular cell 2003;11(5):1215-27.
2003: Seth Abhinav; Otomo Takanori; Yin Helen L; Rosen Michael K
Rational design of genetically encoded fluorescence resonance energy transfer-based sensors of cellular Cdc42 signaling.
Biochemistry 2003;42(14):3997-4008.
2003: Garrard Sarah M; Capaldo Christopher T; Gao Lin; Rosen Michael K; Macara Ian G; Tomchick Diana R
Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6.
The EMBO journal 2003;22(5):1125-33.
2002: Kreishman-Deitrick Mara; Rosen Michael K;
Ignition of a cellular machine.
Nature cell biology 2002;4(2):E31-3.
2001: Buck M; Xu W; Rosen M K
Global disruption of the WASP autoinhibited structure on Cdc42 binding. Ligand displacement as a novel method for monitoring amide hydrogen exchange.
Biochemistry 2001;40(47):14115-22.
2001: Cannon J L; Labno C M; Bosco G; Seth A; McGavin M H; Siminovitch K A; Rosen M K; Burkhardt J K
Wasp recruitment to the T cell:APC contact site occurs independently of Cdc42 activation.
Immunity 2001;15(2):249-59.
2001: Buck M; Rosen M K
Structural biology. Flipping a switch.
Science (New York, N.Y.) 2001;291(5512):2329-30.
2001: Devriendt K; Kim A S; Mathijs G; Frints S G; Schwartz M; Van Den Oord J J; Verhoef G E; Boogaerts M A; Fryns J P; You D; Rosen M K; Vandenberghe P
Constitutively activating mutation in WASP causes X-linked severe congenital neutropenia.
Nature genetics 2001;27(3):313-7.
2000: Aghazadeh B; Lowry W E; Huang X Y; Rosen M K
Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation.
Cell 2000;102(5):625-33.
2000: Liu A; Hu W; Majumdar A; Rosen M K; Patel D J
NMR detection of side chain-side chain hydrogen bonding interactions in 13C/15N-labeled proteins.
Journal of biomolecular NMR 2000;17(4):305-10.
2000: Liu A; Hu W; Majumdar A; Rosen M K; Patel D J
Detection of very weak side chain-main chain hydrogen bonding interactions in medium-size 13C/15N-labeled proteins by sensitivity-enhanced NMR spectroscopy.
Journal of biomolecular NMR 2000;17(1):79-82.
2000: Kim A S; Kakalis L T; Abdul-Manan N; Liu G A; Rosen M K
Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein.
Nature 2000;404(6774):151-8.
1999: Aghazadeh B; Rosen M K
Ligand recognition by SH3 and WW domains: the role of N-alkylation in PPII helices.
Chemistry & biology 1999;6(9):R241-6.
1999: Abdul-Manan N; Aghazadeh B; Liu G A; Majumdar A; Ouerfelli O; Siminovitch K A; Rosen M K
Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein.
Nature 1999;399(6734):379-83.
1998: Aghazadeh B; Zhu K; Kubiseski T J; Liu G A; Pawson T; Zheng Y; Rosen M K
Structure and mutagenesis of the Dbl homology domain.
Nature structural biology 1998;5(12):1098-107.
1997: Gosser Y Q; Nomanbhoy T K; Aghazadeh B; Manor D; Combs C; Cerione R A; Rosen M K
C-terminal binding domain of Rho GDP-dissociation inhibitor directs N-terminal inhibitory peptide to GTPases.
Nature 1997;387(6635):814-9.

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Michael Rosen

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