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Herbert Rosenkranz

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Herbert S Rosenkranz; Suzanne L Cunningham; Robert Mermelstein; Albert R Cunningham
The challenge of testing chemicals for potential carcinogenicity using multiple short-term assays: an analysis of a proposed test battery for hair dyes.
Herbert S Rosenkranz; Albert R Cunningham
Lack of predictivity of the rat lethality (LD50) test for ecological and human health effects.
Herbert S Rosenkranz
SAR modeling of genotoxic phenomena: the consequence on predictive performance of deviation from a unity ratio of genotoxicants/non-genotoxicants.

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All Publications

2007: Herbert S Rosenkranz; Suzanne L Cunningham; Robert Mermelstein; Albert R Cunningham
The challenge of testing chemicals for potential carcinogenicity using multiple short-term assays: an analysis of a proposed test battery for hair dyes.
Mutation research 2007;633(1):55-66.
2005: Herbert S Rosenkranz; Albert R Cunningham
Lack of predictivity of the rat lethality (LD50) test for ecological and human health effects.
Alternatives to laboratory animals : ATLA 2005;33(1):9-19.
2004: Herbert S Rosenkranz
SAR modeling of genotoxic phenomena: the consequence on predictive performance of deviation from a unity ratio of genotoxicants/non-genotoxicants.
Mutation research 2004;559(1-2):67-71.
2004: Albert R Cunningham; Suzanne L Cunningham; Herbert S Rosenkranz
Structure-activity approach to the identification of environmental estrogens: the MCASE approach.
SAR and QSAR in environmental research 2004;15(1):55-67.
2003: Herbert S Rosenkranz
SAR modelling of complex phenomena: probing methodological limitations.
Alternatives to laboratory animals : ATLA 2003;31(4):393-9.
2003: Herbert S Rosenkranz; Albert R Cunningham
Environmental odors and health hazards.
The Science of the total environment 2003;313(1-3):15-24.
2003: Herbert S Rosenkranz
Synergy between systemic toxicity and genotoxicity: relevance to human cancer risk.
Mutation research 2003;529(1-2):117-27.
2003: Noam Pollack; Albert R Cunningham; Herbert S Rosenkranz
Environmental persistence of chemicals and their carcinogenic risks to humans.
Mutation research 2003;528(1-2):81-91.
2003: Herbert S Rosenkranz; Albert R Cunningham
A substructure-based SAR model for odor perception in humans relevant to health risk assessments.
SAR and QSAR in environmental research 2003;14(3):215-22.
2003: Herbert S Rosenkranz
A data mining approach for the elucidation of the action of putative etiological agents: application to the non-genotoxic carcinogenicity of genistein.
Mutation research 2003;526(1-2):85-92.
2003: Bhavani P Thampatty; Herbert S Rosenkranz
SAR modeling: effect of experimental ambiguity.
Combinatorial chemistry & high throughput screening 2003;6(2):161-6.
2003: Herbert S Rosenkranz; Bhavani P Thampatty
SAR: flavonoids and COX-2 inhibition.
Oncology research 2003;13(12):529-35.
2002: Herbert S Rosenkranz
A paradigm for determining the relevance of short-term assays: application to oxidative mutagenesis.
Mutation research 2002;508(1-2):21-7.
2002: Bhavani P Thampatty; Herbert S Rosenkranz
Structural concepts in cancer prevention.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 2002;11 Suppl 2():S76-85.
2001: Herbert S Rosenkranz; Albert R Cunningham
Prevalence of mutagens in the environment: experimental data versus simulations.
Mutation research 2001;484(1-2):49-51.
2001: Herbert S Rosenkranz
Allergic contact dermatitis and its relationship to carcinogenicity.
Mutation research 2001;483(1-2):51-5.
2001: Albert R Cunningham; Herbert S Rosenkranz
Estimating the extent of the health hazard posed by high-production volume chemicals.
Environmental health perspectives 2001;109(9):953-6.
2001: Herbert S Rosenkranz; Albert R Cunningham
Chemical categories for health hazard identification: a feasibility study.
Regulatory toxicology and pharmacology : RTP 2001;33(3):313-8.
2001: Herbert S Rosenkranz; Albert R Cunningham
SAR modeling of genotoxic phenomena: the effect of supplementation with physiological chemicals.
Mutation research 2001;476(1-2):133-7.
2001: Herbert S Rosenkranz
Computational toxicology and the generation of mechanistic hypotheses: gamma-butyrolactone.
SAR and QSAR in environmental research 2001;12(5):435-44.
2001: Herbert S Rosenkranz; Albert R Cunningham
SAR modeling of unbalanced data sets.
SAR and QSAR in environmental research 2001;12(3):267-74.
2000: Herbert S Rosenkranz; Albert R Cunningham
A new approach to evaluate mechanistic relationships among genotoxic phenomena: validation.
Mutagenesis 2000;15(4):325-8.
2000: Herbert S Rosenkranz; Noam Pollack; Albert R Cunningham
Exploring the relationship between the inhibition of gap junctional intercellular communication and other biological phenomena.
Carcinogenesis 2000;21(5):1007-11.
2000: Herbert S Rosenkranz; Albert R Cunningham
The high production volume chemical challenge program: the relevance of the in vivo micronucleus assay.
Regulatory toxicology and pharmacology : RTP 2000;31(2 Pt 1):182-9.
2000: Stephen G Grant; YP Zhang; G Klopman; Herbert S Rosenkranz
Modeling the mouse lymphoma forward mutational assay: the Gene-Tox program database.
Mutation research 2000;465(1-2):201-29.
1999: Herbert S Rosenkranz; Meryl H Karol
Chemical carcinogenicity: can it be predicted from knowledge of mutagenicity and allergic contact dermatitis?
Mutation research 1999;431(1):81-91.
1999: Herbert S Rosenkranz; V Mersch-Sundermann; G Klopman
SOS chromotest and mutagenicity in Salmonella: evidence for mechanistic differences.
Mutation research 1999;431(1):31-8.
1999: Noam Pollack; Albert R Cunningham; G Klopman; Herbert S Rosenkranz
Chemical diversity approach for evaluating mechanistic relatedness among toxicological phenomena.
SAR and QSAR in environmental research 1999;10(6):533-43.
1999: J Gómez; OT Macina; Donald R Mattison; YP Zhang; G Klopman; Herbert S Rosenkranz
Structural determinants of developmental toxicity in hamsters.
Teratology 1999;60(4):190-205.
1999: Herbert S Rosenkranz
From mutagen hunter to genome defender, a change in paradigm.
Mutation research 1999;437(2):113-9.
1999: Herbert S Rosenkranz; G Klopman
The mysterious Mauritian red nectar: a selective toxicant?
Die Naturwissenschaften 1999;86(8):404-5.
1999: X Zhu; YP Zhang; G Klopman; Herbert S Rosenkranz
Thalidomide and metabolites: indications of the absence of 'genotoxic' carcinogenic potentials.
Mutation research 1999;425(1):153-67.
1999: Herbert S Rosenkranz; G Klopman; Y P Zhang; C Graham; Meryl H Karol
Relationship between allergic contact dermatitis and electrophilicity.
Environmental health perspectives 1999;107(2):129-32.
1999: Herbert S Rosenkranz
Chlorothalonil: lack of genotoxic potential.
Mutation research 1999;423(1-2):183-6.
1999: Herbert S Rosenkranz; Albert R Cunningham; YP Zhang; HG Claycamp; OT Macina; Nancy Sussman; Stephen G Grant; G Klopman
Development, characterization and application of predictive-toxicology models.
SAR and QSAR in environmental research 1999;10(2-3):277-98.
1999: Herbert S Rosenkranz; Albert R Cunningham; YP Zhang; G Klopman
Applications of the case/multicase SAR method to environmental and public health situations.
SAR and QSAR in environmental research 1999;10(2-3):263-76.
1998: Herbert S Rosenkranz; YP Zhang; OT Macina; Donald R Mattison; G Klopman
Human developmental toxicity and mutagenesis.
Mutation research 1998;422(2):347-50.
1998: Albert R Cunningham; G Klopman; Herbert S Rosenkranz
Identification of structural features and associated mechanisms of action for carcinogens in rats.
Mutation research 1998;405(1):9-27.
1998: Herbert S Rosenkranz; Y P Zhang; G Klopman
Studies on the potential for genotoxic carcinogenicity of fragrances and other chemicals.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1998;36(8):687-96.
1998: Albert R Cunningham; Herbert S Rosenkranz; G Klopman
Structural analysis of a group of phytoestrogens for the presence of a 2-D geometric descriptor associated with non-genotoxic carcinogens and some estrogens.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1998;217(3):288-92.
1998: Albert R Cunningham; Herbert S Rosenkranz; YP Zhang; G Klopman
Identification of 'genotoxic' and 'non-genotoxic' alerts for cancer in mice: the carcinogenic potency database.
Mutation research 1998;398(1-2):1-17.
1998: B Henry; Stephen G Grant; G Klopman; Herbert S Rosenkranz
Induction of forward mutations at the thymidine kinase locus of mouse lymphoma cells: evidence for electrophilic and non-electrophilic mechanisms.
Mutation research 1998;397(2):313-35.
1997: C Graham; Herbert S Rosenkranz; Meryl H Karol
Structure-activity model of chemicals that cause human respiratory sensitization.
Regulatory toxicology and pharmacology : RTP 1997;26(3):296-306.
1997: M Rosenkranz; Herbert S Rosenkranz; G Klopman
Intercellular communication, tumor promotion and non-genotoxic carcinogenesis: relationships based upon structural considerations.
Mutation research 1997;381(2):171-88.
1997: R Johnson; OT Macina; C Graham; Herbert S Rosenkranz; Glen R Cass; Meryl H Karol
Prioritizing testing of organic compounds detected as gas phase air pollutants: structure-activity study for human contact allergens.
Environmental health perspectives 1997;105(9):986-92.
1997: A Labbauf; G Klopman; Herbert S Rosenkranz
Dichotomous relationship between DNA reactivity and the induction of sister chromatid exchanges in vivo and in vitro.
Mutation research 1997;377(1):37-52.
1997: Albert R Cunningham; G Klopman; Herbert S Rosenkranz
A dichotomy in the lipophilicity of natural estrogens, xenoestrogens, and phytoestrogens.
Environmental health perspectives 1997;105 Suppl 3():665-8.
1997: M Ghanooni; Donald R Mattison; YP Zhang; OT Macina; Herbert S Rosenkranz; G Klopman
Structural determinants associated with risk of human developmental toxicity.
American journal of obstetrics and gynecology 1997;176(4):799-805; discussion 805-6.
1997: M Liu; Stephen G Grant; OT Macina; G Klopman; Herbert S Rosenkranz
Structural and mechanistic bases for the induction of mitotic chromosomal loss and duplication ('malsegregation') in the yeast Saccharomyces cerevisiae: relevance to human carcinogenesis and developmental toxicology.
Mutation research 1997;374(2):209-31.
1996: M Liu; N Sussman; G Klopman; Herbert S Rosenkranz
Structure-activity and mechanistic relationships: the effect of chemical overlap on structural overlap in data bases of varying size and composition.
Mutation research 1996;372(1):79-85.
1996: M Liu; N Sussman; G Klopman; Herbert S Rosenkranz
Estimation of the optimal data base size for structure-activity analyses: the Salmonella mutagenicity data base.
Mutation research 1996;358(1):63-72.
1996: Y Lee; Bruce G Buchanan; G Klopman; M Dimayuga; Herbert S Rosenkranz
The potential of organ specific toxicity for predicting rodent carcinogenicity.
Mutation research 1996;358(1):37-62.
1996: Y Lee; Bruce G Buchanan; Herbert S Rosenkranz
Carcinogenicity predictions for a group of 30 chemicals undergoing rodent cancer bioassays based on rules derived from subchronic organ toxicities.
Environmental health perspectives 1996;104 Suppl 5():1059-63.
1996: YP Zhang; N Sussman; OT Macina; Herbert S Rosenkranz; G Klopman
Prediction of the carcinogenicity of a second group of organic chemicals undergoing carcinogenicity testing.
Environmental health perspectives 1996;104 Suppl 5():1045-50.
1996: E ter Haar; Herbert S Rosenkranz; E Hamel; Billy W Day
Computational and molecular modeling evaluation of the structural basis for tubulin polymerization inhibition by colchicine site agents.
Bioorganic & medicinal chemistry 1996;4(10):1659-71.
1996: Meryl H Karol; C Graham; R Gealy; OT Macina; N Sussman; Herbert S Rosenkranz
Structure-activity relationships and computer-assisted analysis of respiratory sensitization potential.
Toxicology letters 1996;86(2-3):187-91.
1996: Herbert S Rosenkranz; G Klopman
A study of the structural basis of the ability of chlorinated alkanes and alkenes to induce aneuploidy and toxicity in the mold Aspergillus nidulans.
Mutation research 1996;354(2):183-93.
1996: R Gealy; C Graham; N B Sussman; OT Macina; Herbert S Rosenkranz; Meryl H Karol
Evaluating clinical case report data for SAR modeling of allergic contact dermatitis.
Human & experimental toxicology 1996;15(6):489-93.
1996: E ter Haar; Billy W Day; Herbert S Rosenkranz
Direct tubulin polymerization perturbation contributes significantly to the induction of micronuclei in vivo.
Mutation research 1996;350(2):331-7.
1996: Herbert S Rosenkranz
Mutagenic nitroarenes, diesel emissions, particulate-induced mutations and cancer: an essay on cancer-causation by a moving target.
Mutation research 1996;367(2):65-72.
1996: A Cunningham; G Klopman; Herbert S Rosenkranz
A study of the structural basis of the carcinogenicity of tamoxifen, toremifene and their metabolites.
Mutation research 1996;349(1):85-94.
1996: E ter Haar; Richard Kowalski; E Hamel; C M Lin; Ross E Longley; Sarath P Gunasekera; Herbert S Rosenkranz; Billy W Day
Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol.
Biochemistry 1996;35(1):243-50.
1996: A Cunningham; G Klopman; Herbert S Rosenkranz
The carcinogenicity of diethylstilbestrol: structural evidence for a non-genotoxic mechanism.
Archives of toxicology 1996;70(6):356-61.
1996: Herbert S Rosenkranz; M Liu; A Cunningham; G Klopman
Application of structural concepts to evaluate the potential carcinogenicity of natural products.
SAR and QSAR in environmental research 1996;5(2):79-98.
1996: Herbert S Rosenkranz; A Cunningham; G Klopman
Identification of a 2-D geometric descriptor associated with non-genotoxic carcinogens and some estrogens and antiestrogens.
Mutagenesis 1996;11(1):95-100.
1996: Herbert S Rosenkranz
Health effects associated with global climate changes: a role for environmental mutagens?
Environmental and molecular mutagenesis 1996;27(2):81-3.
1995: Herbert S Rosenkranz; YP Zhang; G Klopman
Risk identification using structural concepts: the potential carcinogenicity of praziquantel.
Regulatory toxicology and pharmacology : RTP 1995;22(2):152-61.
1995: Herbert S Rosenkranz; G Klopman
Relationships between electronegativity and genotoxicity.
Mutation research 1995;328(2):215-27.
1995: Y Lee; Bruce G Buchanan; D M Mattison; G Klopman; Herbert S Rosenkranz
Learning rules to predict rodent carcinogenicity of non-genotoxic chemicals.
Mutation research 1995;328(2):127-49.
1995: Herbert S Rosenkranz; G Klopman
An examination of the potential "genotoxic" carcinogenicity of a biopesticide derived from the neem tree.
Environmental and molecular mutagenesis 1995;26(3):255-60.
1994: N Takihi; Herbert S Rosenkranz; G Klopman; Donald R Mattison
Structural determinants of developmental toxicity.
Risk analysis : an official publication of the Society for Risk Analysis 1994;14(4):649-57.
1994: Herbert S Rosenkranz; YP Zhang; G Klopman
Evidence that cell toxicity may contribute to the genotoxic response.
Regulatory toxicology and pharmacology : RTP 1994;19(2):176-82.
1994: YP Zhang; A Van Praagh; G Klopman; Herbert S Rosenkranz
Structural basis of the induction of unscheduled DNA synthesis in rat hepatocytes.
Mutagenesis 1994;9(2):141-9.
1994: Herbert S Rosenkranz; G Klopman
Structural implications of the ICPEMC method for quantifying genotoxicity data.
Mutation research 1994;305(1):99-116.
1993: Herbert S Rosenkranz
Revisiting the role of mutagenesis in the induction of lung cancers in rats by diesel emissions.
Mutation research 1993;303(2):91-5.
1993: Herbert S Rosenkranz; G Klopman
Structural evidence for a dichotomy in rodent carcinogenesis: involvement of genetic and cellular toxicity.
Mutation research 1993;303(2):83-9.
1993: N Takihi; YP Zhang; G Klopman; Herbert S Rosenkranz
Development of a method to assess the informational content of structure-activity data bases.
Quality assurance (San Diego, Calif.) 1993;2(3):255-64.
1993: Herbert S Rosenkranz; G Klopman
Predictions based upon the CASE structure-activity relational method are independent of the nature of the chemicals in the data base.
Quality assurance (San Diego, Calif.) 1993;2(3):251-4.
1993: N Takihi; Herbert S Rosenkranz; G Klopman
Identification of chemicals for testing in the rodent cancer bioassay.
Quality assurance (San Diego, Calif.) 1993;2(3):232-43.
1993: Herbert S Rosenkranz; E J Matthews; G Klopman
Commonalities in the structural determinants of toxicity in fish and mammals.
Ecotoxicology and environmental safety 1993;25(3):296-9.
1993: N Takihi; YP Zhang; G Klopman; Herbert S Rosenkranz
An approach for evaluating and increasing the informational content of mutagenicity and clastogenicity data bases.
Mutagenesis 1993;8(3):257-64.
1993: Herbert S Rosenkranz; G Klopman
A dichotomy between lipophilicity and in vivo and in vitro genotoxicity.
Mutation research 1993;291(2):135-9.
1993: Herbert S Rosenkranz; G Klopman
Structural relationships between mutagenicity, maximum tolerated dose, and carcinogenicity in rodents.
Environmental and molecular mutagenesis 1993;21(2):193-206.
1993: YP Zhang; G Klopman; Herbert S Rosenkranz
Structural basis of the mutagenicity of heterocyclic amines formed during the cooking processes.
Environmental and molecular mutagenesis 1993;21(1):100-15.
1992: W L Yang; G Klopman; Herbert S Rosenkranz
Structural basis of the in vivo induction of micronuclei.
Mutation research 1992;272(2):111-24.
1992: Herbert S Rosenkranz; G Klopman
1,4-Dioxane: prediction of in vivo clastogenicity.
Mutation research 1992;280(4):245-51.
1992: Herbert S Rosenkranz; G Klopman
Decreased electrophilicity of chemicals carcinogenic only at the maximum tolerated dose.
Mutation research 1992;282(4):241-6.
1992: Herbert S Rosenkranz
Past plagues and modern biotechnology.
Mutation research 1992;282(1):1-2.
1992: Herbert S Rosenkranz; G Klopman
A structural analysis of the genotoxic and carcinogenic potentials of cyclosporin A.
Mutagenesis 1992;7(2):115-8.
1991: Herbert S Rosenkranz; YP Zhang; G Klopman
Implications of newly recognized relationships between mutagenicity, genotoxicity and carcinogenicity of molecules.
Mutation research 1991;250(1-2):25-33.
1991: Herbert S Rosenkranz; N Takihi; G Klopman
Structure activity-based predictive toxicology: an efficient and economical method for generating non-congeneric data bases.
Mutagenesis 1991;6(5):391-4.
1991: Herbert S Rosenkranz; G Klopman
Omeprazole: an exploration of its reported genotoxicity.
Mutagenesis 1991;6(5):381-4.