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Philip Rosenthal

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Gloria Ikilezi; Abel Kakuru; Moses R Kamya; Philip J Rosenthal; Theodore Ruel; Jane Achan; Edwin Charlebois; Tamara D Clark; Diane Havlir; Grant Dorsey
Prevalence of asymptomatic parasitemia and gametocytemia among HIV-infected Ugandan children randomized to receive different antiretroviral therapies.
Kimberly A Baltzell; Anders Björkman; Kristina Elfving; Michelle Hsiang; Jordan Kemere; Andreas Mårtensson; Mwinyi Msellem; Rahila Omar; Philip J Rosenthal; Deler Shakely; Abdullah Suleiman Ali; Berit Aydin-Schmidt; Bryan Greenhouse
Prevalence of PCR detectable malaria infection among febrile patients with a negative Plasmodium falciparum specific rapid diagnostic test in Zanzibar.
Sumit S Mahajan; Jiri Gut; Philip J Rosenthal; Adam R Renslo
Ferrous iron-dependent delivery of therapeutic agents to the malaria parasite.

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2013: Gloria Ikilezi; Abel Kakuru; Moses R Kamya; Philip J Rosenthal; Theodore Ruel; Jane Achan; Edwin Charlebois; Tamara D Clark; Diane Havlir; Grant Dorsey
Prevalence of asymptomatic parasitemia and gametocytemia among HIV-infected Ugandan children randomized to receive different antiretroviral therapies.
The American journal of tropical medicine and hygiene 2013;88(4):744-6.
2013: Kimberly A Baltzell; Anders Björkman; Kristina Elfving; Michelle Hsiang; Jordan Kemere; Andreas Mårtensson; Mwinyi Msellem; Rahila Omar; Philip J Rosenthal; Deler Shakely; Abdullah Suleiman Ali; Berit Aydin-Schmidt; Bryan Greenhouse
Prevalence of PCR detectable malaria infection among febrile patients with a negative Plasmodium falciparum specific rapid diagnostic test in Zanzibar.
The American journal of tropical medicine and hygiene 2013;88(2):289-91.
2012: Sumit S Mahajan; Jiri Gut; Philip J Rosenthal; Adam R Renslo
Ferrous iron-dependent delivery of therapeutic agents to the malaria parasite.
Future medicinal chemistry 2012;4(18):2241-9.
2012: Jane Achan; Francesca Aweeka; Edwin D Charlebois; Tamara D Clark; Grant Dorsey; Diane V Havlir; Gloria Ikilezi; Abel Kakuru; Christian Nsanzabana; Philip J Rosenthal; Theodore Ruel; Moses R Kamya
Antiretroviral agents and prevention of malaria in HIV-infected Ugandan children.
The New England journal of medicine 2012;367(22):2110-8.
2012: Matshawandile Tukulula; Baojie Wan; Scott G Franzblau; Jiri Gut; Susan Little; Philip J Rosenthal; Kelly Chibale
The design, synthesis, in silico ADME profiling, antiplasmodial and antimycobacterial evaluation of new arylamino quinoline derivatives.
European journal of medicinal chemistry 2012;57():259-67.
2012: Liusheng Huang; Patricia S Lizak; Florence Marzan; Sunil Parikh; Philip J Rosenthal; Grant Dorsey; Diane Havlir; Francesca T Aweeka
Concomitant efavirenz reduces pharmacokinetic exposure to the antimalarial drug artemether-lumefantrine in healthy volunteers.
Journal of acquired immune deficiency syndromes (1999) 2012;61(3):310-6.
2012: Dennis S B Ongarora; Philip J Rosenthal; Jiri Gut; Collen M Masimirembwa; Kelly Chibale
Benzoheterocyclic amodiaquine analogues with potent antiplasmodial activity: synthesis and pharmacological evaluation.
Bioorganic & medicinal chemistry letters 2012;22(15):5046-50.
2012: Lauren Gong; Grant Dorsey; Chris J Drakeley; Alan E Hubbard; Catherine Maiteki-Sebuguzi; Philip J Rosenthal; Bryan Greenhouse
Evidence for both innate and acquired mechanisms of protection from Plasmodium falciparum in children with sickle cell trait.
Blood 2012;119(16):3808-14.
2012: Theodore D Ruel; Jane Achan; Carolyne Akello; Paul Bangirana; Hannah E Boal; Michael J Boivin; Edwin D Charlebois; Grant Dorsey; Diane V Havlir; Moses R Kamya; Philip J Rosenthal; Joseph Wong
Neurocognitive and motor deficits in HIV-infected Ugandan children with high CD4 cell counts.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2012;54(7):1001-9.
2012: Joel Tarning; N J White; Issaka Zongo; N P J Day; W Hanpithakpong; N Jongrak; F Nosten; Jean Bosco Ouedraogo; S Parikh; Philip J Rosenthal; Noel Rouamba; F A Somé; Niklas Lindegardh
Population pharmacokinetics and pharmacodynamics of piperaquine in children with uncomplicated falciparum malaria.
Clinical pharmacology and therapeutics 2012;91(3):497-505.
2012: Ambrose O Talisuna; Seraphine Adibaku; Grant Dorsey; Moses R Kamya; Philip J Rosenthal
Malaria in Uganda: challenges to control on the long road to elimination. II. The path forward.
Acta tropica 2012;121(3):196-201.
2012: Adoke Yeka; Sarah G Staedke; Ambrose O Talisuna; Fred Wabwire-Mangen; Jane Achan; Martin J Donnelly; Grant Dorsey; Anne F Gasasira; Moses R Kamya; Arthur Mpimbaza; Joaniter Nankabirwa; Samuel L Nsobya; Philip J Rosenthal
Malaria in Uganda: challenges to control on the long road to elimination: I. Epidemiology and current control efforts.
Acta tropica 2012;121(3):184-95.
2012: Philip J Rosenthal
How do we best diagnose malaria in Africa?
The American journal of tropical medicine and hygiene 2012;86(2):192-3.
2012: Chris E Keh; David E Lanar; Douglas F Nixon; Bridget Nzarubara; Philip J Rosenthal; Michael Theisen; Grant Dorsey; Sheetij Dutta; Aashish R Jha; Bryan Greenhouse
Associations between antibodies to a panel of Plasmodium falciparum specific antigens and response to sub-optimal antimalarial therapy in Kampala, Uganda.
PloS one 2012;7(12):e52571.
2012: Prasanna Jagannathan; Frank Kaharuza; Abel Kakuru; Moses R Kamya; Mary K Muhindo; Philip J Rosenthal; Jordan W Tappero; Emmanuel Arinaitwe; Bryan Greenhouse; Grant Dorsey
Increasing incidence of malaria in children despite insecticide-treated bed nets and prompt anti-malarial therapy in Tororo, Uganda.
Malaria journal 2012;11():435.
2012: Vinay Gupta; Guillermo I Perez-Perez; Philip J Rosenthal; Grant Dorsey; Martin J Blaser
The seroprevalence of Helicobacter pylori and its relationship to malaria in Ugandan children.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2012;106(1):35-42.
2011: Christian Nsanzabana; Philip J Rosenthal
In vitro activity of antiretroviral drugs against Plasmodium falciparum.
Antimicrobial agents and chemotherapy 2011;55(11):5073-7.
2011: Frederick N Baliraine; Philip J Rosenthal
Prolonged selection of pfmdr1 polymorphisms after treatment of falciparum malaria with artemether-lumefantrine in Uganda.
The Journal of infectious diseases 2011;204(7):1120-4.
2011: Bryan Greenhouse; Benjamin Ho; Alan Hubbard; Denise Njama-Meya; David L Narum; David E Lanar; Sheetij Dutta; Philip J Rosenthal; Grant Dorsey; Chandy C John
Antibodies to Plasmodium falciparum antigens predict a higher risk of malaria but protection from symptoms once parasitemic.
The Journal of infectious diseases 2011;204(1):19-26.
2011: Philip J Rosenthal
Lessons from sickle cell disease in the treatment and control of malaria.
The New England journal of medicine 2011;364(26):2549-51.
2011: Eric M Guantai; Kanyile Ncokazi; Timothy J Egan; Jiri Gut; Philip J Rosenthal; Ravi Bhampidipati; Anitha Kopinathan; Peter J Smith; Kelly Chibale
Enone- and chalcone-chloroquinoline hybrid analogues: in silico guided design, synthesis, antiplasmodial activity, in vitro metabolism, and mechanistic studies.
Journal of medicinal chemistry 2011;54(10):3637-49.
2011: Jiri Gut; Kenny K H Ang; Jennifer Legac; Michelle R Arkin; Philip J Rosenthal; James H McKerrow
An image-based assay for high throughput screening of Giardia lamblia.
Journal of microbiological methods 2011;84(3):398-405.
2011: Frederick N Baliraine; Samuel L Nsobya; Jane Achan; James K Tibenderana; Ambrose O Talisuna; Bryan Greenhouse; Philip J Rosenthal
Limited ability of Plasmodium falciparum pfcrt, pfmdr1, and pfnhe1 polymorphisms to predict quinine in vitro sensitivity or clinical effectiveness in Uganda.
Antimicrobial agents and chemotherapy 2011;55(2):615-22.
2011: Philip J Rosenthal
Falcipains and other cysteine proteases of malaria parasites.
Advances in experimental medicine and biology 2011;712():30-48.
2011: Jane Achan; Frederick N Baliraine; Annette Erhart; Philip J Rosenthal; Ambrose O Talisuna; James K Tibenderana; Adoke Yeka; Umberto D'Alessandro
Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria.
Malaria journal 2011;10():144.
2011: Kenny K H Ang; Joseline Ratnam; Jiri Gut; Jennifer Legac; Elizabeth Hansell; Zachary B Mackey; Katarzyna M Skrzypczynska; Anjan Debnath; Juan C Engel; Philip J Rosenthal; James H McKerrow; Michelle R Arkin; Adam R Renslo
Mining a cathepsin inhibitor library for new antiparasitic drug leads.
PLoS neglected tropical diseases 2011;5(5):e1023.
2011: Theodore D Ruel; Moses R Kamya; Pelin Li; William Pasutti; Edwin D Charlebois; Teri Liegler; Grant Dorsey; Philip J Rosenthal; Diane V Havlir; Joseph Wong; Jane Achan
Early virologic failure and the development of antiretroviral drug resistance mutations in HIV-infected Ugandan children.
Journal of acquired immune deficiency syndromes (1999) 2011;56(1):44-50.
2010: Eric M Guantai; Kanyile Ncokazi; Timothy J Egan; Jiri Gut; Philip J Rosenthal; Peter J Smith; Kelly Chibale
Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds.
Bioorganic & medicinal chemistry 2010;18(23):8243-56.
2010: Edwin D Charlebois; Theodore D Ruel; Anne F Gasasira; Jane Achan; Frederick Kateera; Caroline Akello; Huyen Cao; Grant Dorsey; Philip J Rosenthal; Isaac Ssewanyana; Moses R Kamya; Diane V Havlir
Short-term risk of HIV disease progression and death in Ugandan children not eligible for antiretroviral therapy.
Journal of acquired immune deficiency syndromes (1999) 2010;55(3):330-5.
2010: Setshaba D Khanye; Gregory S Smith; Carmen Lategan; Peter J Smith; Jiri Gut; Philip J Rosenthal; Kelly Chibale
Synthesis and in vitro evaluation of gold(I) thiosemicarbazone complexes for antimalarial activity.
Journal of inorganic biochemistry 2010;104(10):1079-83.
2010: Lisa M Bebell; Christopher D Pilcher; Grant Dorsey; Diane V Havlir; Moses R Kamya; Michael P Busch; Joan Dunn Williams; Charles T Nugent; Christopher Bentsen; Philip J Rosenthal; Edwin D Charlebois
Acute HIV-1 infection is highly prevalent in Ugandan adults with suspected malaria.
AIDS (London, England) 2010;24(12):1945-52.
2010: Anyirékun Fabrice Somé; Yves Y Séré; Christian Dokomajilar; Issaka Zongo; Noel Rouamba; Bryan Greenhouse; Jean Bosco Ouédraogo; Philip J Rosenthal
Selection of known Plasmodium falciparum resistance-mediating polymorphisms by artemether-lumefantrine and amodiaquine-sulfadoxine-pyrimethamine but not dihydroartemisinin-piperaquine in Burkina Faso.
Antimicrobial agents and chemotherapy 2010;54(5):1949-54.
2010: Renate H Hans; Jiri Gut; Philip J Rosenthal; Kelly Chibale
Comparison of the antiplasmodial and falcipain-2 inhibitory activity of beta-amino alcohol thiolactone-chalcone and isatin-chalcone hybrids.
Bioorganic & medicinal chemistry letters 2010;20(7):2234-7.
2010: Samuel L Nsobya; Moses Kiggundu; Sarah Nanyunja; Moses Joloba; Bryan Greenhouse; Philip J Rosenthal
In vitro sensitivities of Plasmodium falciparum to different antimalarial drugs in Uganda.
Antimicrobial agents and chemotherapy 2010;54(3):1200-6.
2010: Sunil Parikh; Philip J Rosenthal
Intermittent preventive therapy for malaria in pregnancy: is sulfadoxine-pyrimethamine the right drug?
Clinical pharmacology and therapeutics 2010;87(2):160-2.
2010: Renate H Hans; Eric M Guantai; Carmen Lategan; Peter J Smith; Baojie Wan; Scott Franzblau; Jiri Gut; Philip J Rosenthal; Kelly Chibale
Synthesis, antimalarial and antitubercular activity of acetylenic chalcones.
Bioorganic & medicinal chemistry letters 2010;20(3):942-4.
2010: Joaniter Nankabirwa; Bonnie Cundill; Sian Clarke; Narcis Kabatereine; Philip J Rosenthal; Grant Dorsey; Simon Brooker; Sarah G Staedke
Efficacy, safety, and tolerability of three regimens for prevention of malaria: a randomized, placebo-controlled trial in Ugandan schoolchildren.
PloS one 2010;5(10):e13438.
2010: Byoung-Kuk Na; Young-An Bae; Young-Gun Zo; Youngchool Choe; Seon-Hee Kim; Prashant V Desai; Mitchell A Avery; Charles S Craik; Tong-Soo Kim; Philip J Rosenthal; Yoon Kong
Biochemical properties of a novel cysteine protease of Plasmodium vivax, vivapain-4.
PLoS neglected tropical diseases 2010;4(10):e849.
2010: Tamara D Clark; Denise Njama-Meya; Bridget Nzarubara; Catherine Maiteki-Sebuguzi; Bryan Greenhouse; Sarah G Staedke; Moses R Kamya; Grant Dorsey; Philip J Rosenthal
Incidence of malaria and efficacy of combination antimalarial therapies over 4 years in an urban cohort of Ugandan children.
PloS one 2010;5(7):e11759.
2010: Anne F Gasasira; Moses R Kamya; Edwin O Ochong; Neil Vora; Jane Achan; Edwin D Charlebois; Theodore Ruel; Fredrick Kateera; Denise N Meya; Diane V Havlir; Philip J Rosenthal; Grant Dorsey
Effect of trimethoprim-sulphamethoxazole on the risk of malaria in HIV-infected Ugandan children living in an area of widespread antifolate resistance.
Malaria journal 2010;9():177.
2010: Vinay Gupta; Grant Dorsey; Alan E Hubbard; Philip J Rosenthal; Bryan Greenhouse
Gel versus capillary electrophoresis genotyping for categorizing treatment outcomes in two anti-malarial trials in Uganda.
Malaria journal 2010;9():19.
2010: Julia Mwesigwa; Sunil Parikh; Bryan McGee; Polina German; Troy Drysdale; Joan N Kalyango; Tamara D Clark; Grant Dorsey; Niklas Lindegardh; Anna Annerberg; Philip J Rosenthal; Moses R Kamya; Francesca T Aweeka
Pharmacokinetics of artemether-lumefantrine and artesunate-amodiaquine in children in Kampala, Uganda.
Antimicrobial agents and chemotherapy 2010;54(1):52-9.
2009: Fatima Nawaz; Samuel L Nsobya; Moses Kiggundu; Moses Joloba; Philip J Rosenthal
Selection of parasites with diminished drug susceptibility by amodiaquine-containing antimalarial regimens in Uganda.
The Journal of infectious diseases 2009;200(11):1650-7.
2009: Emmanuel Arinaitwe; Taylor G Sandison; Humphrey Wanzira; Abel Kakuru; Jaco Homsy; Julius Kalamya; Moses R Kamya; Neil Vora; Bryan Greenhouse; Philip J Rosenthal; Jordan W Tappero; Grant Dorsey
Artemether-lumefantrine versus dihydroartemisinin-piperaquine for falciparum malaria: a longitudinal, randomized trial in young Ugandan children.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2009;49(11):1629-37.
2009: Iain D Kerr; Ji H Lee; Christopher J Farady; Rachael Marion; Mathias Rickert; Mohammed Sajid; Kailash C Pandey; Conor R Caffrey; Jennifer Legac; Elizabeth Hansell; James H McKerrow; Charles S Craik; Philip J Rosenthal; Linda S Brinen
Vinyl sulfones as antiparasitic agents and a structural basis for drug design.
The Journal of biological chemistry 2009;284(38):25697-703.
2009: Lisa M Butler; Grant Dorsey; Wolfgang Hladik; Philip J Rosenthal; Christian Brander; Torsten B Neilands; Georgina Mbisa; Denise Whitby; Photini Kiepiela; Anisa Mosam; Similo Mzolo; Sheila C Dollard; Jeffrey N Martin
Kaposi sarcoma-associated herpesvirus (KSHV) seroprevalence in population-based samples of African children: evidence for at least 2 patterns of KSHV transmission.
The Journal of infectious diseases 2009;200(3):430-8.
2009: Polina German; Sunil Parikh; Jody Lawrence; Grant Dorsey; Philip J Rosenthal; Diane V Havlir; Edwin D Charlebois; Warunee Hanpithakpong; Niklas Lindegardh; Francesca T Aweeka
Lopinavir/ritonavir affects pharmacokinetic exposure of artemether/lumefantrine in HIV-uninfected healthy volunteers.
Journal of acquired immune deficiency syndromes (1999) 2009;51(4):424-9.
2009: Sarah G Staedke; Norah Mwebaza; Moses R Kamya; Tamara D Clark; Grant Dorsey; Philip J Rosenthal; Christopher J M Whitty
Home management of malaria with artemether-lumefantrine compared with standard care in urban Ugandan children: a randomised controlled trial.
Lancet 2009;373(9675):1623-31.
2009: Linda Mobula; Bruce Lilley; Antoinette K Tshefu; Philip J Rosenthal
Resistance-mediating polymorphisms in Plasmodium falciparum infections in Kinshasa, Democratic Republic of the Congo.
The American journal of tropical medicine and hygiene 2009;80(4):555-8.
2009: Bryan Greenhouse; Madeline Slater; Denise Njama-Meya; Bridget Nzarubara; Catherine Maiteki-Sebuguzi; Tamara D Clark; Sarah G Staedke; Moses R Kamya; Alan Hubbard; Philip J Rosenthal; Grant Dorsey
Decreasing efficacy of antimalarial combination therapy in Uganda is explained by decreasing host immunity rather than increasing drug resistance.
The Journal of infectious diseases 2009;199(5):758-65.
2009: Iain D Kerr; Ji H Lee; Kailash C Pandey; Amanda Harrison; Mohammed Sajid; Philip J Rosenthal; Linda S Brinen
Structures of falcipain-2 and falcipain-3 bound to small molecule inhibitors: implications for substrate specificity.
Journal of medicinal chemistry 2009;52(3):852-7.
2009: Marla K Johnson; Tamara D Clark; Denise Njama-Meya; Philip J Rosenthal; Sunil Parikh
Impact of the method of G6PD deficiency assessment on genetic association studies of malaria susceptibility.
PloS one 2009;4(9):e7246.
2009: Trevor P Jensen; Hasifa Bukirwa; Denise Njama-Meya; Damon Francis; Moses R Kamya; Philip J Rosenthal; Grant Dorsey
Use of the slide positivity rate to estimate changes in malaria incidence in a cohort of Ugandan children.
Malaria journal 2009;8():213.
2009: Jane Achan; James K Tibenderana; Daniel Kyabayinze; Fred Wabwire-Mangen; Moses R Kamya; Grant Dorsey; Umberto D'Alessandro; Philip J Rosenthal; Ambrose O Talisuna
Effectiveness of quinine versus artemether-lumefantrine for treating uncomplicated falciparum malaria in Ugandan children: randomised trial.
BMJ (Clinical research ed.) 2009;339():b2763.
2009: Arthur Mpimbaza; Sarah G Staedke; Grace Ndeezi; Justus S Byarugaba; Philip J Rosenthal
Predictors of anti-convulsant treatment failure in children presenting with malaria and prolonged seizures in Kampala, Uganda.
Malaria journal 2009;8():145.
2009: Kailash C Pandey; David T Barkan; Andrej Sali; Philip J Rosenthal
Regulatory elements within the prodomain of Falcipain-2, a cysteine protease of the malaria parasite Plasmodium falciparum.
PloS one 2009;4(5):e5694.
2009: Shoba Subramanian; Markus Hardt; Youngchool Choe; Richard K Niles; Eric B Johansen; Jennifer Legac; Jiri Gut; Iain D Kerr; Charles S Craik; Philip J Rosenthal
Hemoglobin cleavage site-specificity of the Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3.
PloS one 2009;4(4):e5156.
2008: James H McKerrow; Philip J Rosenthal; Ryan Swenerton; Patricia Doyle
Development of protease inhibitors for protozoan infections.
Current opinion in infectious diseases 2008;21(6):668-72.
2008: Charles C Kim; Sunil Parikh; Joseph Sun; Alissa Myrick; Lewis L Lanier; Philip J Rosenthal; Joseph L DeRisi
Experimental malaria infection triggers early expansion of natural killer cells.
Infection and immunity 2008;76(12):5873-82.
2008: Samuel L Nsobya; Moses Kiggundu; Moses L Joloba; Grant Dorsey; Philip J Rosenthal
Complexity of Plasmodium falciparum clinical samples from Uganda during short-term culture.
The Journal of infectious diseases 2008;198(10):1554-7.
2008: Sunil Parikh; Philip J Rosenthal
Human genetics and malaria: relevance for the design of clinical trials.
The Journal of infectious diseases 2008;198(9):1255-7.
2008: Tamara D Clark; Bryan Greenhouse; Denise Njama-Meya; Bridget Nzarubara; Catherine Maiteki-Sebuguzi; Sarah G Staedke; Edmund Seto; Moses R Kamya; Philip J Rosenthal; Grant Dorsey
Factors determining the heterogeneity of malaria incidence in children in Kampala, Uganda.
The Journal of infectious diseases 2008;198(3):393-400.
2008: Theodore D Ruel; Jane Achan; Anne F Gasasira; Edwin D Charlebois; Tsedal Mehbratu; Philip J Rosenthal; Grant Dorsey; Moses R Kamya; Adeodata Kekitiinwa; Joseph Wong; Diane V Havlir
HIV RNA suppression among HIV-infected Ugandan children with measles.
Journal of acquired immune deficiency syndromes (1999) 2008;48(2):225-7.
2008: Erica L Dahl; Philip J Rosenthal
Apicoplast translation, transcription and genome replication: targets for antimalarial antibiotics.
Trends in parasitology 2008;24(6):279-84.
2008: Philip J Rosenthal
Artesunate for the treatment of severe falciparum malaria.
The New England journal of medicine 2008;358(17):1829-36.
2008: Anne F Gasasira; Moses R Kamya; Jane Achan; Tsedal Mebrahtu; Joan N Kalyango; Theodore Ruel; Edwin D Charlebois; Sarah G Staedke; Addy Kekitiinwa; Philip J Rosenthal; Diane V Havlir; Grant Dorsey
High risk of neutropenia in HIV-infected children following treatment with artesunate plus amodiaquine for uncomplicated malaria in Uganda.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2008;46(7):985-91.
2008: Heidi Hopkins; Lisa Bebell; Wilson Kambale; Christian Dokomajilar; Philip J Rosenthal; Grant Dorsey
Rapid diagnostic tests for malaria at sites of varying transmission intensity in Uganda.
The Journal of infectious diseases 2008;197(4):510-8.
2008: Sarah G Staedke; Prasanna Jagannathan; Adoke Yeka; Hasifa Bukirwa; Kristin Banek; Catherine Maiteki-Sebuguzi; Tamara D Clark; Bridget Nzarubara; Denise Njama-Meya; Arthur Mpimbaza; Philip J Rosenthal; Moses R Kamya; Fred Wabwire-Mangen; Grant Dorsey; Ambrose O Talisuna
Monitoring antimalarial safety and tolerability in clinical trials: a case study from Uganda.
Malaria journal 2008;7():107.
2008: Catherine Maiteki-Sebuguzi; Prasanna Jagannathan; Vincent M Yau; Tamara D Clark; Denise Njama-Meya; Bridget Nzarubara; Ambrose O Talisuna; Moses R Kamya; Philip J Rosenthal; Grant Dorsey; Sarah G Staedke
Safety and tolerability of combination antimalarial therapies for uncomplicated falciparum malaria in Ugandan children.
Malaria journal 2008;7():106.
2008: Adoke Yeka; Grant Dorsey; Moses R Kamya; Ambrose O Talisuna; Myers Lugemwa; John Bosco Rwakimari; Sarah G Staedke; Philip J Rosenthal; Fred Wabwire-Mangen; Hasifa Bukirwa
Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treating uncomplicated malaria: a randomized trial to guide policy in Uganda.
PloS one 2008;3(6):e2390.
2008: Arthur Mpimbaza; Grace Ndeezi; Sarah G Staedke; Philip J Rosenthal; Justus S Byarugaba
Comparison of buccal midazolam with rectal diazepam in the treatment of prolonged seizures in Ugandan children: a randomized clinical trial.
Pediatrics 2008;121(1):e58-64.
2007: Lisa M Bebell; Anne F Gasasira; Moses Kiggundu; Christian Dokomajilar; R. Moses Kamya; Edwin D Charlebois; Diane V Havlir; Philip J Rosenthal; Grant Dorsey
HIV-1 infection in patients referred for malaria blood smears at government health clinics in Uganda.
Journal of acquired immune deficiency syndromes (1999) 2007;46(5):624-30.
2007: Issaka Zongo; Grant Dorsey; Noel Rouamba; Christian Dokomajilar; Yves Séré; Philip J Rosenthal; Jean Bosco Ouédraogo
Randomized comparison of amodiaquine plus sulfadoxine-pyrimethamine, artemether-lumefantrine, and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Burkina Faso.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2007;45(11):1453-61.
2007: christophe biot; Bruno Pradines; Marie-Hélène Sergeant; Jiri Gut; Philip J Rosenthal; Kelly Chibale
Design, synthesis, and antimalarial activity of structural chimeras of thiosemicarbazone and ferroquine analogues.
Bioorganic & medicinal chemistry letters 2007;17(23):6434-8.
2007: R. Moses Kamya; Anne F Gasasira; Jane Achan; Tsedal Mebrahtu; Theodore Ruel; Addy Kekitiinwa; Edwin D Charlebois; Philip J Rosenthal; Diane V Havlir; Grant Dorsey
Effects of trimethoprim-sulfamethoxazole and insecticide-treated bednets on malaria among HIV-infected Ugandan children.
AIDS (London, England) 2007;21(15):2059-66.
2007: Erica L Dahl; Philip J Rosenthal
Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplast.
Antimicrobial agents and chemotherapy 2007;51(10):3485-90.
2007: Bryan Greenhouse; Christian Dokomajilar; Alan Hubbard; Philip J Rosenthal; Grant Dorsey
Impact of transmission intensity on the accuracy of genotyping to distinguish recrudescence from new infection in antimalarial clinical trials.
Antimicrobial agents and chemotherapy 2007;51(9):3096-103.
2007: Shoba Subramanian; Puran S Sijwali; Philip J Rosenthal
Falcipain cysteine proteases require bipartite motifs for trafficking to the Plasmodium falciparum food vacuole.
The Journal of biological chemistry 2007;282(34):24961-9.
2007: Samuel L Nsobya; Christian Dokomajilar; Moses L Joloba; Grant Dorsey; Philip J Rosenthal
Resistance-mediating Plasmodium falciparum pfcrt and pfmdr1 alleles after treatment with artesunate-amodiaquine in Uganda.
Antimicrobial agents and chemotherapy 2007;51(8):3023-5.
2007: Sunil Parikh; Jean Bosco Ouedraogo; J A Goldstein; Philip J Rosenthal; Deanna L Kroetz
Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa.
Clinical pharmacology and therapeutics 2007;82(2):197-203.
2007: Heidi Hopkins; Wilson Kambale; R. Moses Kamya; Sarah G Staedke; Grant Dorsey; Philip J Rosenthal
Comparison of HRP2- and pLDH-based rapid diagnostic tests for malaria with longitudinal follow-up in Kampala, Uganda.
The American journal of tropical medicine and hygiene 2007;76(6):1092-7.
2007: Grant Dorsey; Sarah G Staedke; Tamara D Clark; Denise Njama-Meya; Bridget Nzarubara; Catherine Maiteki-Sebuguzi; Christian Dokomajilar; R. Moses Kamya; Philip J Rosenthal
Combination therapy for uncomplicated falciparum malaria in Ugandan children: a randomized trial.
JAMA : the journal of the American Medical Association 2007;297(20):2210-9.
2007: Stephanie X Wang; Kailash C Pandey; Julio Scharfstein; James C Whisstock; Rick K Huang; Jordan Jacobelli; Robert J Fletterick; Philip J Rosenthal; Magnus Abrahamson; Linda S Brinen; Andrea Rossi; Andrej Sali; James H McKerrow
The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family.
Structure (London, England : 1993) 2007;15(5):535-43.
2007: Ajay Singh; K Jordan Walker; Puran S Sijwali; Anthony L Lau; Philip J Rosenthal
A chimeric cysteine protease of Plasmodium berghei engineered to resemble the Plasmodium falciparum protease falcipain-2.
Protein engineering, design & selection : PEDS 2007;20(4):171-7.
2007: Polina German; Bryan Greenhouse; Carrie Coates; Grant Dorsey; Philip J Rosenthal; Edwin D Charlebois; Niklas Lindegardh; Diane V Havlir; Francesca T Aweeka
Hepatotoxicity due to a drug interaction between amodiaquine plus artesunate and efavirenz.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2007;44(6):889-91.
2007: Issaka Zongo; Grant Dorsey; Noel Rouamba; Halidou Tinto; Christian Dokomajilar; Robert T Guiguemde; Philip J Rosenthal; Jean Bosco Ouedraogo
Artemether-lumefantrine versus amodiaquine plus sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Burkina Faso: a randomised non-inferiority trial.
Lancet 2007;369(9560):491-8.
2007: R. Moses Kamya; Adoke Yeka; Hasifa Bukirwa; Myers Lugemwa; John Bosco Rwakimari; Sarah G Staedke; Ambrose O Talisuna; Bryan Greenhouse; François Nosten; Philip J Rosenthal; Fred Wabwire-Mangen; Grant Dorsey
Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment of malaria: a randomized trial.
PLoS clinical trials 2007;2(5):e20.
2007: Alex Chipeleme; Jiri Gut; Philip J Rosenthal; Kelly Chibale
Synthesis and biological evaluation of phenolic Mannich bases of benzaldehyde and (thio)semicarbazone derivatives against the cysteine protease falcipain-2 and a chloroquine resistant strain of Plasmodium falciparum.
Bioorganic & medicinal chemistry 2007;15(1):273-82.
2006: Bryan Greenhouse; Alissa Myrick; Christian Dokomajilar; Jonathan M Woo; Elaine J Carlson; Philip J Rosenthal; Grant Dorsey
Validation of microsatellite markers for use in genotyping polyclonal Plasmodium falciparum infections.
The American journal of tropical medicine and hygiene 2006;75(5):836-42.
2006: Kailash C Pandey; Naresh Singh; Shirin Arastu-Kapur; Matthew Bogyo; Philip J Rosenthal
Falstatin, a cysteine protease inhibitor of Plasmodium falciparum, facilitates erythrocyte invasion.
PLoS pathogens 2006;2(11):e117.
2006: Puran S Sijwali; Jamie Koo; Naresh Singh; Philip J Rosenthal
Gene disruptions demonstrate independent roles for the four falcipain cysteine proteases of Plasmodium falciparum.
Molecular and biochemical parasitology 2006;150(1):96-106.
2006: Erica L Dahl; Jennifer L Shock; Bhaskar R Shenai; Jiri Gut; Joe L DeRisi; Philip J Rosenthal
Tetracyclines specifically target the apicoplast of the malaria parasite Plasmodium falciparum.
Antimicrobial agents and chemotherapy 2006;50(9):3124-31.
2006: Chitalu C Musonda; Jiri Gut; Philip J Rosenthal; Vanessa Yardley; Renata C Carvalho de Souza; Kelly Chibale
Application of multicomponent reactions to antimalarial drug discovery. Part 2: New antiplasmodial and antitrypanosomal 4-aminoquinoline gamma- and delta-lactams via a 'catch and release' protocol.
Bioorganic & medicinal chemistry 2006;14(16):5605-15.
2006: Anne F Gasasira; Grant Dorsey; R. Moses Kamya; Diane V Havlir; Moses Kiggundu; Philip J Rosenthal; Edwin D Charlebois
False-positive results of enzyme immunoassays for human immunodeficiency virus in patients with uncomplicated malaria.
Journal of clinical microbiology 2006;44(8):3021-4.
2006: Stephanie X Wang; Kailash C Pandey; John R Somoza; Puran S Sijwali; Tanja Kortemme; Linda S Brinen; Robert J Fletterick; Philip J Rosenthal; James H McKerrow
Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(31):11503-8.
2006: Christian Dokomajilar; Zambende Moise Lankoande; Grant Dorsey; Issaka Zongo; Jean Bosco Ouedraogo; Philip J Rosenthal
Roles of specific Plasmodium falciparum mutations in resistance to amodiaquine and sulfadoxine-pyrimethamine in Burkina Faso.
The American journal of tropical medicine and hygiene 2006;75(1):162-5.
2006: Sunil Parikh; Jun Liu; Puran S Sijwali; Jiri Gut; Daniel E Goldberg; Philip J Rosenthal
Antimalarial effects of human immunodeficiency virus type 1 protease inhibitors differ from those of the aspartic protease inhibitor pepstatin.
Antimicrobial agents and chemotherapy 2006;50(6):2207-9.
2006: Hasifa Bukirwa; Adoke Yeka; R. Moses Kamya; Ambrose O Talisuna; Kristin Banek; Nathan Bakyaita; John Bosco Rwakimari; Philip J Rosenthal; Fred Wabwire-Mangen; Grant Dorsey; Sarah G Staedke
Artemisinin combination therapies for treatment of uncomplicated malaria in Uganda.
PLoS clinical trials 2006;1(1):e7.
2006: Alissa Myrick; Erika Leemann; Christian Dokomajilar; Heidi Hopkins; Grant Dorsey; R. Moses Kamya; Philip J Rosenthal
Short report: Dynamics of Plasmodium falciparum malaria after sub-optimal therapy in Uganda.
The American journal of tropical medicine and hygiene 2006;74(5):758-61.
2006: Christian Dokomajilar; Samuel L Nsobya; Bryan Greenhouse; Philip J Rosenthal; Grant Dorsey
Selection of Plasmodium falciparum pfmdr1 alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemic.
Antimicrobial agents and chemotherapy 2006;50(5):1893-5.
2006: Sulggi A Lee; Adoke Yeka; Samuel L Nsobya; Christian Dokomajilar; Philip J Rosenthal; Ambrose O Talisuna; Grant Dorsey
Complexity of Plasmodium falciparum infections and antimalarial drug efficacy at 7 sites in Uganda.
The Journal of infectious diseases 2006;193(8):1160-3.
2006: Damon Francis; Samuel L Nsobya; Ambrose O Talisuna; Adoke Yeka; R. Moses Kamya; Rhoderick Machekano; Christian Dokomajilar; Philip J Rosenthal; Grant Dorsey
Geographic differences in antimalarial drug efficacy in Uganda are explained by differences in endemicity and not by known molecular markers of drug resistance.
The Journal of infectious diseases 2006;193(7):978-86.
2006: Naresh Singh; Puran S Sijwali; Kailash C Pandey; Philip J Rosenthal
Plasmodium falciparum: biochemical characterization of the cysteine protease falcipain-2'.
Experimental parasitology 2006;112(3):187-92.
2006: William J Collins; Bryan Greenhouse; Philip J Rosenthal; Grant Dorsey
The use of genotyping in antimalarial clinical trials: a systematic review of published studies from 1995-2005.
Malaria journal 2006;5():122.
2006: Mark P Eggena; Heidi Hopkins; Banson Barugahare; Martin Okello; Francis Ssali; Peter Mugyenyi; Philip J Rosenthal; Huyen Cao; Grant Dorsey
CD4 T cell activation as a predictor for treatment failure in Ugandans with Plasmodium falciparum malaria.
The American journal of tropical medicine and hygiene 2006;74(1):41-3.
2006: R. Moses Kamya; Anne F Gasasira; Adoke Yeka; Nathan Bakyaita; Samuel L Nsobya; Damon Francis; Philip J Rosenthal; Grant Dorsey; Diane V Havlir
Effect of HIV-1 infection on antimalarial treatment outcomes in Uganda: a population-based study.
The Journal of infectious diseases 2006;193(1):9-15.
2005: Issaka Zongo; Grant Dorsey; Noel Rouamba; Christian Dokomajilar; Moise Lankoande; Jean Bosco Ouedraogo; Philip J Rosenthal
Amodiaquine, sulfadoxine-pyrimethamine, and combination therapy for uncomplicated falciparum malaria: a randomized controlled trial from Burkina Faso.
The American journal of tropical medicine and hygiene 2005;73(5):826-32.
2005: Madeline Slater; Moses Kiggundu; Christian Dokomajilar; R. Moses Kamya; Nathan Bakyaita; Ambrose O Talisuna; Philip J Rosenthal; Grant Dorsey
Distinguishing recrudescences from new infections in antimalarial clinical trials: major impact of interpretation of genotyping results on estimates of drug efficacy.
The American journal of tropical medicine and hygiene 2005;73(2):256-62.
2005: Adoke Yeka; Kristin Banek; Nathan Bakyaita; Sarah G Staedke; R. Moses Kamya; Ambrose O Talisuna; Fred Kironde; Samuel L Nsobya; Albert Kilian; Madeline Slater; Arthur Reingold; Philip J Rosenthal; Fred Wabwire-Mangen; Grant Dorsey
Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda.
PLoS medicine 2005;2(7):e190.
2005: Sunil Parikh; Jiri Gut; Eva Istvan; Daniel E Goldberg; Diane V Havlir; Philip J Rosenthal
Antimalarial activity of human immunodeficiency virus type 1 protease inhibitors.
Antimicrobial agents and chemotherapy 2005;49(7):2983-5.
2005: Kailash C Pandey; Stephanie X Wang; Puran S Sijwali; Anthony L Lau; James H McKerrow; Philip J Rosenthal
The Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin, via a unique motif.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(26):9138-43.
2005: Idan Chiyanzu; Cailean Clarkson; Peter J Smith; Julie Lehman; Jiri Gut; Philip J Rosenthal; Kelly Chibale
Design, synthesis and anti-plasmodial evaluation in vitro of new 4-aminoquinoline isatin derivatives.
Bioorganic & medicinal chemistry 2005;13(9):3249-61.
2005: Nathan Bakyaita; Grant Dorsey; Adoke Yeka; Kristin Banek; Sarah G Staedke; R. Moses Kamya; Ambrose O Talisuna; Fred Kironde; Samuel L Nsobya; Albert Kilian; Arthur Reingold; Philip J Rosenthal; Fred Wabwire-Mangen
Sulfadoxine-pyrimethamine plus chloroquine or amodiaquine for uncomplicated falciparum malaria: a randomized, multisite trial to guide national policy in Uganda.
The American journal of tropical medicine and hygiene 2005;72(5):573-80.
2005: Erica L Dahl; Philip J Rosenthal
Biosynthesis, localization, and processing of falcipain cysteine proteases of Plasmodium falciparum.
Molecular and biochemical parasitology 2005;139(2):205-12.
2005: Naoaki Fujii; Jeremy P Mallari; Elizabeth Hansell; Zachary B Mackey; Patricia Doyle; Y M Zhou; Jiri Gut; Philip J Rosenthal; James H McKerrow; R Kiplin Guy
Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain.
Bioorganic & medicinal chemistry letters 2005;15(1):121-3.
2004: Grant Dorsey; Christian Dokomajilar; Moses Kiggundu; Sarah G Staedke; R. Moses Kamya; Philip J Rosenthal
Principal role of dihydropteroate synthase mutations in mediating resistance to sulfadoxine-pyrimethamine in single-drug and combination therapy of uncomplicated malaria in Uganda.
The American journal of tropical medicine and hygiene 2004;71(6):758-63.
2004: Sunil Parikh; Grant Dorsey; Philip J Rosenthal
Host polymorphisms and the incidence of malaria in Ugandan children.
The American journal of tropical medicine and hygiene 2004;71(6):750-3.
2004: Philip J Rosenthal
Cysteine proteases of malaria parasites.
International journal for parasitology 2004;34(13-14):1489-99.
2004: Sarah G Staedke; Arthur Mpimbaza; R. Moses Kamya; Bridget Nzarubara; Grant Dorsey; Philip J Rosenthal
Combination treatments for uncomplicated falciparum malaria in Kampala, Uganda: randomised clinical trial.
Lancet 2004;364(9449):1950-7.
2004: Ajay Singh; Philip J Rosenthal
Selection of cysteine protease inhibitor-resistant malaria parasites is accompanied by amplification of falcipain genes and alteration in inhibitor transport.
The Journal of biological chemistry 2004;279(34):35236-41.
2004: Chitalu C Musonda; Dale Taylor; Julie Lehman; Jiri Gut; Philip J Rosenthal; Kelly Chibale
Application of multi-component reactions to antimalarial drug discovery. Part 1: Parallel synthesis and antiplasmodial activity of new 4-aminoquinoline Ugi adducts.
Bioorganic & medicinal chemistry letters 2004;14(15):3901-5.
2004: Samuel L Nsobya; Sunil Parikh; Fred Kironde; George W Lubega; R. Moses Kamya; Philip J Rosenthal; Grant Dorsey
Molecular evaluation of the natural history of asymptomatic parasitemia in Ugandan children.
The Journal of infectious diseases 2004;189(12):2220-6.
2004: Puran S Sijwali; Kentaro Kato; Karl Boynton Seydel; Jiri Gut; Julie Lehman; Michael Klemba; Daniel E Goldberg; Louis H Miller; Philip J Rosenthal
Plasmodium falciparum cysteine protease falcipain-1 is not essential in erythrocytic stage malaria parasites.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(23):8721-6.
2004: Doron C Greenbaum; Zachary B Mackey; Elizabeth Hansell; Patricia Doyle; Jiri Gut; Conor R Caffrey; Julia Lehrman; Philip J Rosenthal; James H McKerrow; Kelly Chibale
Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi.
Journal of medicinal chemistry 2004;47(12):3212-9.
2004: Sarah G Staedke; Hakim Sendagire; Steven Lamola; R. Moses Kamya; Grant Dorsey; Philip J Rosenthal
Relationship between age, molecular markers, and response to sulphadoxine-pyrimethamine treatment in Kampala, Uganda.
Tropical medicine & international health : TM & IH 2004;9(5):624-9.
2004: Puran S Sijwali; Philip J Rosenthal
Gene disruption confirms a critical role for the cysteine protease falcipain-2 in hemoglobin hydrolysis by Plasmodium falciparum.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(13):4384-9.
2004: Byoung-Kuk Na; Bhaskar R Shenai; Puran S Sijwali; Youngchool Choe; Kailash C Pandey; Ajay Singh; Charles S Craik; Philip J Rosenthal
Identification and biochemical characterization of vivapains, cysteine proteases of the malaria parasite Plasmodium vivax.
The Biochemical journal 2004;378(Pt 2):529-38.
2004: Kailash C Pandey; Puran S Sijwali; Ajay Singh; Byoung-Kuk Na; Philip J Rosenthal
Independent intramolecular mediators of folding, activity, and inhibition for the Plasmodium falciparum cysteine protease falcipain-2.
The Journal of biological chemistry 2004;279(5):3484-91.
2003: Belinda J Lee; Ajay Singh; Peggy Chiang; Scott J Kemp; Erick A Goldman; Michael I Weinhouse; George P Vlasuk; Philip J Rosenthal
Antimalarial activities of novel synthetic cysteine protease inhibitors.
Antimicrobial agents and chemotherapy 2003;47(12):3810-4.
2003: Philip J Rosenthal
Antimalarial drug discovery: old and new approaches.
The Journal of experimental biology 2003;206(Pt 21):3735-44.
2003: Idan Chiyanzu; Elizabeth Hansell; Jiri Gut; Philip J Rosenthal; James H McKerrow; Kelly Chibale
Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain.
Bioorganic & medicinal chemistry letters 2003;13(20):3527-30.
2003: Grant Dorsey; Jonathan Vlahos; R. Moses Kamya; Sarah G Staedke; Philip J Rosenthal
Prevention of increasing rates of treatment failure by combining sulfadoxine-pyrimethamine with artesunate or amodiaquine for the sequential treatment of malaria.
The Journal of infectious diseases 2003;188(8):1231-8.
2003: Daniel Kyabayinze; Adithya Cattamanchi; R. Moses Kamya; Philip J Rosenthal; Grant Dorsey
Validation of a simplified method for using molecular markers to predict sulfadoxine-pyrimethamine treatment failure in African children with falciparum malaria.
The American journal of tropical medicine and hygiene 2003;69(3):247-52.
2003: Sarah G Staedke; E Willis Nottingham; Jonathan Cox; R. Moses Kamya; Philip J Rosenthal; Grant Dorsey
Short report: proximity to mosquito breeding sites as a risk factor for clinical malaria episodes in an urban cohort of Ugandan children.
The American journal of tropical medicine and hygiene 2003;69(3):244-6.
2003: Adithya Cattamanchi; Daniel Kyabayinze; Alan Hubbard; Philip J Rosenthal; Grant Dorsey
Distinguishing recrudescence from reinfection in a longitudinal antimalarial drug efficacy study: comparison of results based on genotyping of msp-1, msp-2, and glurp.
The American journal of tropical medicine and hygiene 2003;68(2):133-9.
2003: Anne F Gasasira; Grant Dorsey; Bridget Nzarubara; Sarah G Staedke; Annette Nassali; Philip J Rosenthal; R. Moses Kamya
Comparative efficacy of aminoquinoline-antifolate combinations for the treatment of uncomplicated falciparum malaria in Kampala, Uganda.
The American journal of tropical medicine and hygiene 2003;68(2):127-32.
2003: Bhaskar R Shenai; Belinda J Lee; Alejandro Alvarez-Hernandez; Pek Y Chong; Cory D Emal; R Jeffrey Neitz; William R Roush; Philip J Rosenthal
Structure-activity relationships for inhibition of cysteine protease activity and development of Plasmodium falciparum by peptidyl vinyl sulfones.
Antimicrobial agents and chemotherapy 2003;47(1):154-60.
2002: Grant Dorsey; Denise Njama; R. Moses Kamya; Adithya Cattamanchi; Daniel Kyabayinze; Sarah G Staedke; Anne F Gasasira; Philip J Rosenthal
Sulfadoxine/pyrimethamine alone or with amodiaquine or artesunate for treatment of uncomplicated malaria: a longitudinal randomised trial.
Lancet 2002;360(9350):2031-8.
2002: Ajay Singh; Bhaskar R Shenai; Youngchool Choe; Jiri Gut; Puran S Sijwali; Charles S Craik; Philip J Rosenthal
Critical role of amino acid 23 in mediating activity and specificity of vinckepain-2, a papain-family cysteine protease of rodent malaria parasites.
The Biochemical journal 2002;368(Pt 1):273-81.
2002: Bhaskar R Shenai; Philip J Rosenthal
Reducing requirements for hemoglobin hydrolysis by Plasmodium falciparum cysteine proteases.
Molecular and biochemical parasitology 2002;122(1):99-104.
2002: Bhaskar R Shenai; Andrey V Semenov; Philip J Rosenthal
Stage-specific antimalarial activity of cysteine protease inhibitors.
Biological chemistry 2002;383(5):843-7.
2002: Puran S Sijwali; Bhaskar R Shenai; Philip J Rosenthal
Folding of the Plasmodium falciparum cysteine protease falcipain-2 is mediated by a chaperone-like peptide and not the prodomain.
The Journal of biological chemistry 2002;277(17):14910-5.
2002: Philip J Rosenthal
Hydrolysis of erythrocyte proteins by proteases of malaria parasites.
Current opinion in hematology 2002;9(2):140-5.
2002: Philip J Rosenthal; Puran S Sijwali; Ajay Singh; Bhaskar R Shenai
Cysteine proteases of malaria parasites: targets for chemotherapy.
Current pharmaceutical design 2002;8(18):1659-72.
2001: Puran S Sijwali; Bhaskar R Shenai; Jiri Gut; Ajay Singh; Philip J Rosenthal
Expression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3.
The Biochemical journal 2001;360(Pt 2):481-9.
2001: Sarah G Staedke; R. Moses Kamya; Grant Dorsey; Anne F Gasasira; Grace Ndeezi; Edwin D Charlebois; Philip J Rosenthal
Amodiaquine, sulfadoxine/pyrimethamine, and combination therapy for treatment of uncomplicated falciparum malaria in Kampala, Uganda: a randomised trial.
Lancet 2001;358(9279):368-74.
2001: Puran S Sijwali; Linda S Brinen; Philip J Rosenthal
Systematic optimization of expression and refolding of the Plasmodium falciparum cysteine protease falcipain-2.
Protein expression and purification 2001;22(1):128-34.
2001: Grant Dorsey; R. Moses Kamya; A Singh; Philip J Rosenthal
Polymorphisms in the Plasmodium falciparum pfcrt and pfmdr-1 genes and clinical response to chloroquine in Kampala, Uganda.
The Journal of infectious diseases 2001;183(9):1417-20.
2001: Ajay Singh; Philip J Rosenthal
Comparison of efficacies of cysteine protease inhibitors against five strains of Plasmodium falciparum.
Antimicrobial agents and chemotherapy 2001;45(3):949-51.
2001: R. Moses Kamya; Grant Dorsey; Anne F Gasasira; Grace Ndeezi; J N Babirye; Sarah G Staedke; Philip J Rosenthal
The comparative efficacy of chloroquine and sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in Kampala, Uganda.
Transactions of the Royal Society of Tropical Medicine and Hygiene 2001;95(1):50-5.
2000: Bhaskar R Shenai; Puran S Sijwali; Ajay Singh; Philip J Rosenthal
Characterization of native and recombinant falcipain-2, a principal trophozoite cysteine protease and essential hemoglobinase of Plasmodium falciparum.
The Journal of biological chemistry 2000;275(37):29000-10.
2000: Grant Dorsey; R. Moses Kamya; Grace Ndeezi; J N Babirye; C R Phares; J E Olson; Elly Katabira; Philip J Rosenthal
Predictors of chloroquine treatment failure in children and adults with falciparum malaria in Kampala, Uganda.
The American journal of tropical medicine and hygiene 2000;62(6):686-92.
1999: J E Olson; G K Lee; A Semenov; Philip J Rosenthal
Antimalarial effects in mice of orally administered peptidyl cysteine protease inhibitors.
Bioorganic & medicinal chemistry 1999;7(4):633-8.
1999: Philip J Rosenthal
Proteases of protozoan parasites.
Advances in parasitology 1999;43():105-59.
1998: Philip J Rosenthal; A Semenov; V A Ploplis; E F Plow
Plasminogen activators are not required in the erythrocytic life cycle of malaria parasites.
Molecular and biochemical parasitology 1998;97(1-2):253-7.
1998: DO Gor; A C Li; M F Wiser; Philip J Rosenthal
Plasmodial serine repeat antigen homologues with properties of schizont cysteine proteases.
Molecular and biochemical parasitology 1998;95(1):153-8.
1998: A Semenov; J E Olson; Philip J Rosenthal
Antimalarial synergy of cysteine and aspartic protease inhibitors.
Antimicrobial agents and chemotherapy 1998;42(9):2254-8.
1998: DO Gor; A C Li; Philip J Rosenthal
Protective immune responses against protease-like antigens of the murine malaria parasite Plasmodium vinckei.
Vaccine 1998;16(11-12):1193-202.
1998: DO Gor; Philip J Rosenthal
Humoral immune responses of Africans to cysteine protease-related antigens of Plasmodium falciparum.
The Journal of infectious diseases 1998;178(1):285-8.
1996: Philip J Rosenthal; Steven R Meshnick
Hemoglobin catabolism and iron utilization by malaria parasites.
Molecular and biochemical parasitology 1996;83(2):131-9.
1996: Philip J Rosenthal; J E Olson; G K Lee; James Palmer; J L Klaus; D Rasnick
Antimalarial effects of vinyl sulfone cysteine proteinase inhibitors.
Antimicrobial agents and chemotherapy 1996;40(7):1600-3.
1996: N D Gamboa de Domínguez; Philip J Rosenthal
Cysteine proteinase inhibitors block early steps in hemoglobin degradation by cultured malaria parasites.
Blood 1996;87(10):4448-54.
1996: Philip J Rosenthal
Conservation of key amino acids among the cysteine proteinases of multiple malarial species.
Molecular and biochemical parasitology 1996;75(2):255-60.
1995: F Salas; J Fichmann; G K Lee; M D Scott; Philip J Rosenthal
Functional expression of falcipain, a Plasmodium falciparum cysteine proteinase, supports its role as a malarial hemoglobinase.
Infection and immunity 1995;63(6):2120-5.
1995: Philip J Rosenthal
Plasmodium falciparum: effects of proteinase inhibitors on globin hydrolysis by cultured malaria parasites.
Experimental parasitology 1995;80(2):272-81.
1994: Z Li; X Chen; E Davidson; O Zwang; C Mendis; C S Ring; W R Roush; G Fegley; R Li; Philip J Rosenthal
Anti-malarial drug development using models of enzyme structure.
Chemistry & biology 1994;1(1):31-7.
1994: Philip J Rosenthal; C S Ring; X Chen; Fred Cohen
Characterization of a Plasmodium vivax cysteine proteinase gene identifies uniquely conserved amino acids that may mediate the substrate specificity of malarial hemoglobinases.
Journal of molecular biology 1994;241(2):312-6.
1993: Philip J Rosenthal
A Plasmodium vinckei cysteine proteinase shares unique features with its Plasmodium falciparum analogue.
Biochimica et biophysica acta 1993;1173(1):91-3.
1993: C S Ring; E Sun; James H McKerrow; G K Lee; Philip J Rosenthal; Irwin D Kuntz; Fred Cohen
Structure-based inhibitor design by using protein models for the development of antiparasitic agents.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(8):3583-7.
1993: Philip J Rosenthal; G K Lee; R E Smith
Inhibition of a Plasmodium vinckei cysteine proteinase cures murine malaria.
The Journal of clinical investigation 1993;91(3):1052-6.
1993: James H McKerrow; E Sun; Philip J Rosenthal; J Bouvier
The proteases and pathogenicity of parasitic protozoa.
Annual review of microbiology 1993;47():821-53.
1992: Philip J Rosenthal; RG Nelson
Isolation and characterization of a cysteine proteinase gene of Plasmodium falciparum.
Molecular and biochemical parasitology 1992;51(1):143-52.
1991: Philip J Rosenthal; W S Wollish; James Palmer; D Rasnick
Antimalarial effects of peptide inhibitors of a Plasmodium falciparum cysteine proteinase.
The Journal of clinical investigation 1991;88(5):1467-72.
1989: Philip J Rosenthal; James H McKerrow; D Rasnick; J H Leech
Plasmodium falciparum: inhibitors of lysosomal cysteine proteinases inhibit a trophozoite proteinase and block parasite development.
Molecular and biochemical parasitology 1989;35(2):177-83.
1988: Philip J Rosenthal; James H McKerrow; M Aikawa; H Nagasawa; J H Leech
A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum.
The Journal of clinical investigation 1988;82(5):1560-6.
1988: Philip J Rosenthal; Richard E Chaisson; W K Hadley; J H Leech
Rectal leishmaniasis in a patient with acquired immunodeficiency syndrome.
The American journal of medicine 1988;84(2):307-9.
1987: Philip J Rosenthal; Kami Kim; James H McKerrow; J H Leech
Identification of three stage-specific proteinases of Plasmodium falciparum.
The Journal of experimental medicine 1987;166(3):816-21.