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Hilde Rosing

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Jeroen J M A Hendrikx; Jurjen S Lagas; Hilde Rosing; Jan H M Schellens; Jos H Beijnen; Alfred H Schinkel
P-glycoprotein and cytochrome P450 3A act together in restricting the oral bioavailability of paclitaxel.
A Kort; Hilde Rosing; J H M Schellens; Alfred H Schinkel; E E Voest; G A Cirkel; M J X Hillebrand; Jos H Beijnen
Quantification of cabazitaxel, its metabolite docetaxel and the determination of the demethylated metabolites RPR112698 and RPR123142 as docetaxel equivalents in human plasma by liquid chromatography-tandem mass spectrometry.
N A G Lankheet; Hilde Rosing; J H M Schellens; Jos H Beijnen; M J X Hillebrand; A D R Huitema
Method development and validation for the quantification of dasatinib, erlotinib, gefitinib, imatinib, lapatinib, nilotinib, sorafenib and sunitinib in human plasma by liquid chromatography coupled with tandem mass spectrometry.

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2013: Jeroen J M A Hendrikx; Jurjen S Lagas; Hilde Rosing; Jan H M Schellens; Jos H Beijnen; Alfred H Schinkel
P-glycoprotein and cytochrome P450 3A act together in restricting the oral bioavailability of paclitaxel.
International journal of cancer. Journal international du cancer 2013;132(10):2439-47.
2013: A Kort; Hilde Rosing; J H M Schellens; Alfred H Schinkel; E E Voest; G A Cirkel; M J X Hillebrand; Jos H Beijnen
Quantification of cabazitaxel, its metabolite docetaxel and the determination of the demethylated metabolites RPR112698 and RPR123142 as docetaxel equivalents in human plasma by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2013;925():117-23.
2013: N A G Lankheet; Hilde Rosing; J H M Schellens; Jos H Beijnen; M J X Hillebrand; A D R Huitema
Method development and validation for the quantification of dasatinib, erlotinib, gefitinib, imatinib, lapatinib, nilotinib, sorafenib and sunitinib in human plasma by liquid chromatography coupled with tandem mass spectrometry.
Biomedical chromatography : BMC 2013;27(4):466-76.
2013: W Kromdijk; J W Mulder; S A Pereira; Hilde Rosing; Jos H Beijnen; A D R Huitema
Development and validation of an assay for the simultaneous determination of zidovudine, abacavir, emtricitabine, lamivudine, tenofovir and ribavirin in human plasma using liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2013;919-920():43-51.
2013: Anne-Charlotte Dubbelman; Edward Hellriegel; Philmore Robertson; Hilde Rosing; Jos H Beijnen; Mary Bond; Denise D'Andrea; Mona Darwish; Jan H M Schellens
Pharmacokinetics and excretion of (14)c-bendamustine in patients with relapsed or refractory malignancy.
Drugs in R&D 2013;13(1):17-28.
2013: Bojana Milojkovic Kerklaan; Jos H Beijnen; Veronique Diéras; Anne-Sophie Govaerts; Alwin D R Huitema; Bojana Milojkovic Kerklaan; Christophe Le Tourneau; Sandrine Marreaud; Marja Mergui-Roelvink; Martine J Piccart-Gebhart; Hilde Rosing; Jan H M Schellens; Ahmad Awada
Phase I study of lonafarnib (SCH66336) in combination with trastuzumab plus paclitaxel in Her2/neu overexpressing breast cancer: EORTC study 16023.
Cancer chemotherapy and pharmacology 2013;71(1):53-62.
2012: Andrew K L Goey; Irma Meijerman; Hilde Rosing; Jan H M Schellens; Rolf W Sparidans; Jos H Beijnen
The bioanalysis of the major Echinacea purpurea constituents dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides in human plasma using LC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2012;902():151-6.
2012: Anne-Charlotte Dubbelman; Edward Hellriegel; Robert S Jansen; Philmore Robertson; Hilde Rosing; Jan H M Schellens; Mona Darwish; Jos H Beijnen
Metabolite profiling of bendamustine in urine of cancer patients after administration of [14C]bendamustine.
Drug metabolism and disposition: the biological fate of chemicals 2012;40(7):1297-307.
2012: Robert S Jansen; Ron J Keizer; Hilde Rosing; Jan H M Schellens; Pierre W Wijermans; Jos H Beijnen
Decitabine triphosphate levels in peripheral blood mononuclear cells from patients receiving prolonged low-dose decitabine administration: a pilot study.
Cancer chemotherapy and pharmacology 2012;69(6):1457-66.
2012: A C Dubbelman; A Gebretensae; S H Gorman; L Nan; P Robertson; Hilde Rosing; J H M Schellens; M Tibben; Jos H Beijnen
Development and validation of LC-MS/MS assays for the quantification of bendamustine and its metabolites in human plasma and urine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2012;893-894():92-100.
2012: W Kromdijk; Hilde Rosing; M P H van den Broek; Jos H Beijnen; A D R Huitema
Quantitative determination of oseltamivir and oseltamivir carboxylate in human fluoride EDTA plasma including the ex vivo stability using high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2012;891-892():57-63.
2012: A C Dubbelman; A Gebretensae; L Lucas; Hilde Rosing; J H M Schellens; R Shumaker; Bas Thijssen; H Chen; Jos H Beijnen
Development and validation of LC-MS/MS assays for the quantification of E7080 and metabolites in various human biological matrices.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2012;887-888():25-34.
2012: Anne-Charlotte Dubbelman; Alwin D R Huitema; Robert S Jansen; Barbara Koetz; Arturo Lopez-Anaya; Margarita Lymboura; Marja Mergui-Roelvink; Larisa Reyderman; Hilde Rosing; Jan H M Schellens; Jos H Beijnen
Mass balance study of [¹⁴C]eribulin in patients with advanced solid tumors.
Drug metabolism and disposition: the biological fate of chemicals 2012;40(2):313-21.
2012: Seng Chuan Tang; Jos H Beijnen; Michel J X Hillebrand; Jurjen S Lagas; Nienke A G Lankheet; Birk Poller; Hilde Rosing; Alfred H Schinkel
Brain accumulation of sunitinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration.
International journal of cancer. Journal international du cancer 2012;130(1):223-33.
2011: Jeroen J M A Hendrikx; Michel J X Hillebrand; Hilde Rosing; Jan H M Schellens; Alfred H Schinkel; Bas Thijssen; Jos H Beijnen
A sensitive combined assay for the quantification of paclitaxel, docetaxel and ritonavir in human plasma using liquid chromatography coupled with tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2011;879(28):2984-90.
2011: Nienke A G Lankheet; Henk Mallo; Hilde Rosing; Jan H M Schellens; Sandra Adriaansz; Christian U Blank; Alwin D R Huitema; Jos H Beijnen
Determination of sunitinib and its active metabolite N-desethylsunitinib in sweat of a patient.
Journal of analytical toxicology 2011;35(8):558-65.
2011: S F Teunissen; N G L Jager; Hilde Rosing; Alfred H Schinkel; J H M Schellens; Jos H Beijnen
Development and validation of a quantitative assay for the determination of tamoxifen and its five main phase I metabolites in human serum using liquid chromatography coupled with tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2011;879(19):1677-85.
2011: Bas Teunissen; Hilde Rosing; M Dominguez Seoane; L Brunsveld; J H M Schellens; Alfred H Schinkel; Jos H Beijnen
Investigational study of tamoxifen phase I metabolites using chromatographic and spectroscopic analytical techniques.
Journal of pharmaceutical and biomedical analysis 2011;55(3):518-26.
2011: Dilek Iusuf; Sebastiaan F Teunissen; Els Wagenaar; Hilde Rosing; Jos H Beijnen; Alfred H Schinkel
P-glycoprotein (ABCB1) transports the primary active tamoxifen metabolites endoxifen and 4-hydroxytamoxifen and restricts their brain penetration.
The Journal of pharmacology and experimental therapeutics 2011;337(3):710-7.
2011: A C Dubbelman; Hilde Rosing; Bas Thijssen; L Lucas; William Copalu; J Wanders; J H M Schellens; Jos H Beijnen
Validation of high-performance liquid chromatography-tandem mass spectrometry assays for the quantification of eribulin (E7389) in various biological matrices.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2011;879(15-16):1149-55.
2011: Robert S Jansen; Hilde Rosing; Jan H M Schellens; Jos H Beijnen
Deoxyuridine analog nucleotides in deoxycytidine analog treatment: secondary active metabolites?
Fundamental & clinical pharmacology 2011;25(2):172-85.
2011: Robert S Jansen; Hilde Rosing; Jan H M Schellens; Jos H Beijnen
Mass spectrometry in the quantitative analysis of therapeutic intracellular nucleotide analogs.
Mass spectrometry reviews 2011;30(2):321-43.
2011: Andrew K L Goey; Rolf W Sparidans; Irma Meijerman; Hilde Rosing; Jan H M Schellens; Jos H Beijnen
A sensitive LC-MS/MS method for the quantitative analysis of the Echinacea purpurea constituent undeca-2-ene-8,10-diynoic acid isobutylamide in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2011;879(1):41-8.
2010: Bas Teunissen; Hilde Rosing; Alfred H Schinkel; J H M Schellens; Jos H Beijnen
Bioanalytical methods for determination of tamoxifen and its phase I metabolites: a review.
Analytica chimica acta 2010;683(1):21-37.
2010: Robert A B van Waterschoot; Jurjen S Lagas; Els Wagenaar; Hilde Rosing; Jos H Beijnen; Alfred H Schinkel
Individual and combined roles of CYP3A, P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) in the pharmacokinetics of docetaxel.
International journal of cancer. Journal international du cancer 2010;127(12):2959-64.
2010: Bas Teunissen; Hilde Rosing; Alfred H Schinkel; J H M Schellens; Jos H Beijnen
Review on the analysis of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and its phase I and phase II metabolites in biological matrices, foodstuff and beverages.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2010;878(31):3199-216.
2010: Bas Teunissen; Maria L H Vlaming; Hilde Rosing; J H M Schellens; Alfred H Schinkel; Jos H Beijnen
Development and validation of a liquid chromatography-tandem mass spectrometry assay for the analysis of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and its metabolite 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP) in plasma, urine, bile, intestinal contents, faeces and eight selected tissues from mice.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2010;878(25):2353-62.
2010: Rob ter Heine; Hilde Rosing; Jos H Beijnen; Alwin D R Huitema
A less sensitive detector does not necessarily result in a less sensitive method: fast quantification of 13 antiretroviral analytes in plasma with liquid chromatography coupled with tandem mass spectrometry.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2010;48(8):1153-5.
2010: Liia D Vainchtein; Hilde Rosing; Jan H M Schellens; Jos H Beijnen
A new, validated HPLC-MS/MS method for the simultaneous determination of the anti-cancer agent capecitabine and its metabolites: 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, 5-fluorouracil and 5-fluorodihydrouracil, in human plasma.
Biomedical chromatography : BMC 2010;24(4):374-86.
2010: Roos L Oostendorp; Petronella O Witteveen; B Schwartz; L D Vainchtein; Margaret Schot; A Nol; Hilde Rosing; Jos H Beijnen; Emile E Voest; J H M Schellens
Dose-finding and pharmacokinetic study of orally administered indibulin (D-24851) to patients with advanced solid tumors.
Investigational new drugs 2010;28(2):163-70.
2010: Jan-Hendrik Beumer; N E Franke; R Tolboom; Tessa Buckle; Hilde Rosing; Luis Lopez-Lazaro; J H M Schellens; Jos H Beijnen; Olaf van Tellingen
Disposition and toxicity of trabectedin (ET-743) in wild-type and mdr1 gene (P-gp) knock-out mice.
Investigational new drugs 2010;28(2):145-55.
2010: Robert S Jansen; Hilde Rosing; Wiete Kromdijk; Rob ter Heine; Jan Hm Schellens; Jos H Beijnen
Simultaneous quantification of emtricitabine and tenofovir nucleotides in peripheral blood mononuclear cells using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2010;878(7-8):621-7.
2010: Marlies H G Langenberg; Petronella O Witteveen; Nienke A G Lankheet; Jeanine Ml Roodhart; Hilde Rosing; Ingeborg J G M van den Heuvel; Jos H Beijnen; Emile E Voest
Phase 1 study of combination treatment with PTK 787/ZK 222584 and cetuximab for patients with advanced solid tumors: safety, pharmacokinetics, pharmacodynamics analysis.
Neoplasia (New York, N.Y.) 2010;12(2):206-13.
2010: Robert Jansen; Hilde Rosing; Jan H M Schellens; Jos H Beijnen
Facile small scale synthesis of nucleoside 5'-phosphate mixtures.
Nucleosides, nucleotides & nucleic acids 2010;29(1):14-26.
2010: Carola W N Damen; Hilde Rosing; Jan H M Schellens; Jos H Beijnen
High-performance liquid chromatography coupled with mass spectrometry for the quantitative analysis of vinca-alkaloids in biological matrices: a concise survey from the literature.
Biomedical chromatography : BMC 2010;24(1):83-90.
2009: Carola W N Damen; Ellen J B Derissen; Jan H M Schellens; Hilde Rosing; Jos H Beijnen
The bioanalysis of the monoclonal antibody trastuzumab by high-performance liquid chromatography with fluorescence detection after immuno-affinity purification from human serum.
Journal of pharmaceutical and biomedical analysis 2009;50(5):861-6.
2009: Robert A B van Waterschoot; Jurjen S Lagas; Els Wagenaar; Cornelia M M van der Kruijssen; Antonius E van Herwaarden; Ji-Ying Song; Rogier W Rooswinkel; Olaf van Tellingen; Hilde Rosing; Jos H Beijnen; Alfred H Schinkel
Absence of both cytochrome P450 3A and P-glycoprotein dramatically increases docetaxel oral bioavailability and risk of intestinal toxicity.
Cancer research 2009;69(23):8996-9002.
2009: Carola W N Damen; Jurjen S Lagas; Hilde Rosing; Jan H M Schellens; Jos H Beijnen
The bioanalysis of vinorelbine and 4-O-deacetylvinorelbine in human and mouse plasma using high-performance liquid chromatography coupled with heated electrospray ionization tandem mass-spectrometry.
Biomedical chromatography : BMC 2009;23(12):1316-25.
2009: A G Lankheet; Michel J X Hillebrand; M H G Langenberg; Hilde Rosing; A D R Huitema; E E Voest; J H M Schellens; Jos H Beijnen
A validated assay for the quantitative analysis of vatalanib in human EDTA plasma by liquid chromatography coupled with electrospray ionization tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(29):3625-30.
2009: Carola W N Damen; Weibin Chen; Asish B Chakraborty; Mike van Oosterhout; Jeffrey R Mazzeo; John C Gebler; Jan H M Schellens; Hilde Rosing; Jos H Beijnen
Electrospray ionization quadrupole ion-mobility time-of-flight mass spectrometry as a tool to distinguish the lot-to-lot heterogeneity in N-glycosylation profile of the therapeutic monoclonal antibody trastuzumab.
Journal of the American Society for Mass Spectrometry 2009;20(11):2021-33.
2009: Robert Jansen; Hilde Rosing; Jan H M Schellens; Jos H Beijnen
Simultaneous quantification of 2',2'-difluorodeoxycytidine and 2',2'-difluorodeoxyuridine nucleosides and nucleotides in white blood cells using porous graphitic carbon chromatography coupled with tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM 2009;23(19):3040-50.
2009: Robert S Jansen; Hilde Rosing; Jan H M Schellens; Jos H Beijnen
Protein versus DNA as a marker for peripheral blood mononuclear cell counting.
Analytical and bioanalytical chemistry 2009;395(3):863-7.
2009: Carola W N Damen; Han Speijer; Wim T Hermens; Jan H M Schellens; Hilde Rosing; Jos H Beijnen
The bioanalysis of trastuzumab in human serum using precipitate-enhanced ellipsometry.
Analytical biochemistry 2009;393(1):73-9.
2009: Bas Teunissen; Hilde Rosing; R H T Koornstra; Sabine C Linn; J H M Schellens; Alfred H Schinkel; Jos H Beijnen
Development and validation of a quantitative assay for the analysis of tamoxifen with its four main metabolites and the flavonoids daidzein, genistein and glycitein in human serum using liquid chromatography coupled with tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(24):2519-29.
2009: Carola W N Damen; Els R de Groot; Marianne Heij; David Boss; Jan H M Schellens; Hilde Rosing; Jos H Beijnen; Lucien A Aarden
Development and validation of an enzyme-linked immunosorbent assay for the quantification of trastuzumab in human serum and plasma.
Analytical biochemistry 2009;391(2):114-20.
2009: David Boss; Wandena S Siegel-Lakhai; Nadja E van Egmond-Schoemaker; Dick Pluim; Hilde Rosing; Wim W ten Bokkel Huinink; Jos H Beijnen; Jan H M Schellens
Phase I pharmacokinetic and pharmacodynamic study of Carboplatin and topotecan administered intravenously every 28 days to patients with malignant solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(13):4475-83.
2009: Roos L Oostendorp; Alwin D R Huitema; Hilde Rosing; Robert Jansen; Rob ter Heine; Marianne Keessen; Jos H Beijnen; Jan H M Schellens
Coadministration of ritonavir strongly enhances the apparent oral bioavailability of docetaxel in patients with solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(12):4228-33.
2009: Carola W N Damen; Hilde Rosing; Jan H M Schellens; Jos H Beijnen
Application of dried blood spots combined with high-performance liquid chromatography coupled with electrospray ionisation tandem mass spectrometry for simultaneous quantification of vincristine and actinomycin-D.
Analytical and bioanalytical chemistry 2009;394(4):1171-82.
2009: Robert S Jansen; Hilde Rosing; Jan H M Schellens; Jos H Beijnen
Retention studies of 2'-2'-difluorodeoxycytidine and 2'-2'-difluorodeoxyuridine nucleosides and nucleotides on porous graphitic carbon: development of a liquid chromatography-tandem mass spectrometry method.
Journal of chromatography. A 2009;1216(15):3168-74.
2009: Jurjen S Lagas; Robert A B van Waterschoot; Vicky A C J van Tilburg; Michel J X Hillebrand; Nienke Lankheet; Hilde Rosing; Jos H Beijnen; Alfred H Schinkel
Brain accumulation of dasatinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by elacridar treatment.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(7):2344-51.
2009: Roos L Oostendorp; J Loftiss; SANJAY GOEL; D A Smith; M M Dar; Petronella O Witteveen; R B Cohen; L D Lewis; S Kurian; A Patnaik; Hilde Rosing; Jos H Beijnen; Emile E Voest; H Burris
Bioequivalence study of a new oral topotecan formulation, relative to the current topotecan formulation, in patients with advanced solid tumors.
International journal of clinical pharmacology and therapeutics 2009;47(3):195-206.
2009: Carola W N Damen; Trijn Israëls; Huib N Caron; Jan H M Schellens; Hilde Rosing; Jos H Beijnen
Validated assay for the simultaneous quantification of total vincristine and actinomycin-D concentrations in human EDTA plasma and of vincristine concentrations in human plasma ultrafiltrate by high-performance liquid chromatography coupled with tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM 2009;23(6):763-74.
2009: R Ter Heine; Hilde Rosing; Eric C M van Gorp; Jan W Mulder; Jos H Beijnen; Alwin D R Huitema
Quantification of etravirine (TMC125) in plasma, dried blood spots and peripheral blood mononuclear cell lysate by liquid chromatography tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis 2009;49(2):393-400.
2009: R ter Heine; M Davids; Hilde Rosing; Eric C M van Gorp; Jan W Mulder; Y T van der Heide; Jos H Beijnen; Alwin D R Huitema
Quantification of HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors in peripheral blood mononuclear cell lysate using liquid chromatography coupled with tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(5-6):575-80.
2008: Stephan A Veltkamp; Robert Jansen; Sophie Callies; Dick Pluim; Carla M Visseren-Grul; Hilde Rosing; Susanne Kloeker-Rhoades; Valerie A M Andre; Jos H Beijnen; Christopher A Slapak; Jan H M Schellens
Oral administration of gemcitabine in patients with refractory tumors: a clinical and pharmacologic study.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(11):3477-86.
2008: Carola W N Damen; Hilde Rosing; Matthijs M Tibben; Maria J van Maanen; Jurjen S Lagas; Alfred H Schinkel; Jan H M Schellens; Jos H Beijnen
A sensitive assay for the quantitative analysis of vinorelbine in mouse and human EDTA plasma by high-performance liquid chromatography coupled with electrospray tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;868(1-2):102-9.
2008: Rob ter Heine; Hilde Rosing; Eric C M van Gorp; Jan W Mulder; W A van der Steeg; Jos H Beijnen; Alwin D R Huitema
Quantification of protease inhibitors and non-nucleoside reverse transcriptase inhibitors in dried blood spots by liquid chromatography-triple quadrupole mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;867(2):205-12.
2008: E E M Brouwers; Matthijs M Tibben; Dick Pluim; Hilde Rosing; H Boot; A Cats; J H M Schellens; Jos H Beijnen
Inductively coupled plasma mass spectrometric analysis of the total amount of platinum in DNA extracts from peripheral blood mononuclear cells and tissue from patients treated with cisplatin.
Analytical and bioanalytical chemistry 2008;391(2):577-85.
2008: Thomas Dorlo; Michel J X Hillebrand; Hilde Rosing; Teunis A Eggelte; Peter de Vries; Jos H Beijnen
Development and validation of a quantitative assay for the measurement of miltefosine in human plasma by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;865(1-2):55-62.
2008: Elke E M Brouwers; Matthijs Tibben; Hilde Rosing; Jan H M Schellens; Jos H Beijnen
The application of inductively coupled plasma mass spectrometry in clinical pharmacological oncology research.
Mass spectrometry reviews 2008;27(2):67-100.
2008: Carola W N Damen; Hilde Rosing; Jan H M Schellens; Jos H Beijnen
Quantitative aspects of the analysis of the monoclonal antibody trastuzumab using high-performance liquid chromatography coupled with electrospray mass spectrometry.
Journal of pharmaceutical and biomedical analysis 2008;46(3):449-55.
2008: Liia D Vainchtein; Hilde Rosing; Dorla Mirejovsky; Van Huynh; Luigi Lenaz; Jan H M Schellens; Jos H Beijnen
Enhanced resolution triple-quadrupole mass spectrometry for ultra-sensitive and quantitative analysis of the investigational anticancer agent EO9 (apaziquone) and its metabolite EO5a in human and dog plasma to support (pre)-clinical studies of EOquin given intravesically.
Rapid communications in mass spectrometry : RCM 2008;22(4):462-70.
2007: Antonius E van Herwaarden; Els Wagenaar; Cornelia M M van der Kruijssen; Robert A B van Waterschoot; Johan W Smit; Ji-Ying Song; Martin van der Valk; Olaf van Tellingen; José W A van der Hoorn; Hilde Rosing; Jos H Beijnen; Alfred H Schinkel
Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism.
The Journal of clinical investigation 2007;117(11):3583-92.
2007: Markus Joerger; Alwin D R Huitema; manon huizing; P H B Willemse; A de Graeff; Hilde Rosing; J H M Schellens; Jos H Beijnen; Jan B Vermorken
Safety and pharmacology of paclitaxel in patients with impaired liver function: a population pharmacokinetic-pharmacodynamic study.
British journal of clinical pharmacology 2007;64(5):622-33.
2007: Stephan A Veltkamp; Hilde Rosing; Alwin D R Huitema; M R Fetell; A Nol; Jos H Beijnen; J H M Schellens
Novel paclitaxel formulations for oral application: a phase I pharmacokinetic study in patients with solid tumours.
Cancer chemotherapy and pharmacology 2007;60(5):635-42.
2007: Liia D Vainchtein; Hilde Rosing; Armin Maier; Heinz-Herbert Fiebig; Jan H M Schellens; Jos H Beijnen
Quantitative and selective assay of 5-methylindirubine, an inhibitor of cyclin-dependent kinases, in murine plasma using coupled liquid chromatography and electrospray tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;856(1-2):261-6.
2007: Corine Ekhart; Abadi Gebretensae; Hilde Rosing; Sjoerd Rodenhuis; Jos H Beijnen; Alwin D R Huitema
Simultaneous quantification of cyclophosphamide and its active metabolite 4-hydroxycyclophosphamide in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (LC-MS/MS).
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;854(1-2):345-9.
2007: johan jonker; Sandra Musters; Maria L H Vlaming; Torsten Plösch; Karin E R Gooijert; Michel J X Hillebrand; Hilde Rosing; Jos H Beijnen; Henkjan J Verkade; Alfred H Schinkel
Breast cancer resistance protein (Bcrp1/Abcg2) is expressed in the harderian gland and mediates transport of conjugated protoporphyrin IX.
American journal of physiology. Cell physiology 2007;292(6):C2204-12.
2007: Jan-Hendrik Beumer; Jeany M Rademaker-Lakhai; Hilde Rosing; Michel J X Hillebrand; Tessa M Bosch; Luis Lopez-Lazaro; Jan H M Schellens; Jos H Beijnen
Metabolism of trabectedin (ET-743, Yondelis) in patients with advanced cancer.
Cancer chemotherapy and pharmacology 2007;59(6):825-37.
2007: Antonius E van Herwaarden; Els Wagenaar; Gracia Merino; johan jonker; Hilde Rosing; Jos H Beijnen; Alfred H Schinkel
Multidrug transporter ABCG2/breast cancer resistance protein secretes riboflavin (vitamin B2) into milk.
Molecular and cellular biology 2007;27(4):1247-53.
2007: Liia D Vainchtein; Hilde Rosing; Dorla Mirejovsky; Luigi Lenaz; Jan H M Schellens; Jos H Beijnen
Stability experiments in human urine with EO9 (apaziquone): a novel anticancer agent for the intravesical treatment of bladder cancer.
Journal of pharmaceutical and biomedical analysis 2007;43(1):285-92.
2007: Robert Jansen; Hilde Rosing; Cornelia J F De Wolf; Jos H Beijnen
Development and validation of an assay for the quantitative determination of cladribine nucleotides in MDCKII cells and culture medium using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM 2007;21(24):4049-59.
2007: Rob ter Heine; Carolien G Alderden-Los; Hilde Rosing; Michel J X Hillebrand; Eric C M van Gorp; Alwin D R Huitema; Jos H Beijnen
Fast and simultaneous determination of darunavir and eleven other antiretroviral drugs for therapeutic drug monitoring: method development and validation for the determination of all currently approved HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors in human plasma by liquid chromatography coupled with electrospray ionization tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM 2007;21(15):2505-14.
2007: Liia D Vainchtein; Hilde Rosing; Bas Thijssen; Jan H M Schellens; Jos H Beijnen
Validated assay for the simultaneous determination of the anti-cancer agent gemcitabine and its metabolite 2',2'-difluorodeoxyuridine in human plasma by high-performance liquid chromatography with tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM 2007;21(14):2312-22.
2007: E E M Brouwers; Matthijs M Tibben; Hilde Rosing; Jan H M Schellens; Jos H Beijnen
Determination of ruthenium originating from the investigational anti-cancer drug NAMI-A in human plasma ultrafiltrate, plasma, and urine by inductively coupled plasma mass spectrometry.
Rapid communications in mass spectrometry : RCM 2007;21(9):1521-30.
2007: Stephan A Veltkamp; C Alderden-Los; A Sharma; Hilde Rosing; Jos H Beijnen; J H M Schellens
A pharmacokinetic and safety study of a novel polymeric paclitaxel formulation for oral application.
Cancer chemotherapy and pharmacology 2007;59(1):43-50.
2006: Stephan A Veltkamp; Michel J X Hillebrand; Hilde Rosing; Robert Jansen; E R Wickremsinhe; E J Perkins; J H M Schellens; Jos H Beijnen
Quantitative analysis of gemcitabine triphosphate in human peripheral blood mononuclear cells using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry.
Journal of mass spectrometry : JMS 2006;41(12):1633-42.
2006: Jurjen S Lagas; Maria L H Vlaming; Olaf van Tellingen; Els Wagenaar; Robert Jansen; Hilde Rosing; Jos H Beijnen; Alfred H Schinkel
Multidrug resistance protein 2 is an important determinant of paclitaxel pharmacokinetics.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(20 Pt 1):6125-32.
2006: Liia D Vainchtein; Hilde Rosing; Dorla Mirejovsky; Van Huynh; Luigi Lenaz; Michel J X Hillebrand; Jan H M Schellens; Jos H Beijnen
Quantitative analysis of EO9 (apaziquone) and its metabolite EO5a in human plasma by high-performance liquid chromatography under basic conditions coupled to electrospray tandem mass spectrometry.
Journal of mass spectrometry : JMS 2006;41(10):1268-76.
2006: E E M Brouwers; Matthijs M Tibben; Hilde Rosing; Michel J X Hillebrand; Markus Joerger; J H M Schellens; Jos H Beijnen
Sensitive inductively coupled plasma mass spectrometry assay for the determination of platinum originating from cisplatin, carboplatin, and oxaliplatin in human plasma ultrafiltrate.
Journal of mass spectrometry : JMS 2006;41(9):1186-94.
2006: Maria L H Vlaming; K Mohrmann; Els Wagenaar; Dirk R de Waart; Ronald P J Oude Elferink; Jurjen S Lagas; Olaf van Tellingen; Liia D Vainchtein; Hilde Rosing; Jos H Beijnen; J H M Schellens; Alfred H Schinkel
Carcinogen and anticancer drug transport by Mrp2 in vivo: studies using Mrp2 (Abcc2) knockout mice.
The Journal of pharmacology and experimental therapeutics 2006;318(1):319-27.
2006: Natalie M G M Appels; Hilde Rosing; Trevor C Stephens; Andrew Hughes; Jan H M Schellens; Jos H Beijnen
Absolute quantification of farnesylated Ras levels in complex samples using liquid chromatography fractionation combined with tryptic digestion and electrospray tandem mass spectrometry.
Analytical biochemistry 2006;352(1):33-40.
2006: Natalie M G M Appels; Hilde Rosing; Trevor C Stephens; Jan H M Schellens; Jos H Beijnen
Quantification of farnesylmethylcysteine in lysates of peripheral blood mononuclear cells using liquid chromatography coupled with electrospray tandem mass spectrometry: pharmacodynamic assay for farnesyl transferase inhibitors.
Analytical chemistry 2006;78(8):2617-22.
2006: Natalie M G M Appels; Kien-On Tung; Hilde Rosing; Jan H M Schellens; Jos H Beijnen
A rapid and simple HPLC-UV method for the determination of inhibition characteristics of farnesyl transferase inhibitors.
Biomedical chromatography : BMC 2006;20(2):161-5.
2006: Liia D Vainchtein; Bas Thijssen; Ellen Stokvis; Hilde Rosing; Jan H M Schellens; Jos H Beijnen
A simple and sensitive assay for the quantitative analysis of paclitaxel and metabolites in human plasma using liquid chromatography/tandem mass spectrometry.
Biomedical chromatography : BMC 2006;20(1):139-48.
2005: Ellen Stokvis; Hilde Rosing; Jos H Beijnen
Liquid chromatography-mass spectrometry for the quantitative bioanalysis of anticancer drugs.
Mass spectrometry reviews 2005;24(6):887-917.
2005: Jan-Hendrik Beumer; Jeany M Rademaker-Lakhai; Hilde Rosing; Luis Lopez-Lazaro; Jos H Beijnen; J H M Schellens
Trabectedin (Yondelis, formerly ET-743), a mass balance study in patients with advanced cancer.
Investigational new drugs 2005;23(5):429-36.
2005: Elisabeth J Rook; Michel J X Hillebrand; Hilde Rosing; Jan M Van Ree; Jos H Beijnen
The quantitative analysis of heroin, methadone and their metabolites and the simultaneous detection of cocaine, acetylcodeine and their metabolites in human plasma by high-performance liquid chromatography coupled with tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;824(1-2):213-21.
2005: Jan-Hendrik Beumer; Michel J X Hillebrand; Dick Pluim; Hilde Rosing; Karen Foley; S Murray Yule; Jan H M Schellens; Jos H Beijnen
Human metabolism of [(14)C]indisulam following i.v. infusion in cancer patients.
Investigational new drugs 2005;23(4):317-30.
2005: E E M Brouwers; Matthijs M Tibben; Markus Joerger; Olaf van Tellingen; Hilde Rosing; J H M Schellens; Jos H Beijnen
Determination of oxaliplatin in human plasma and plasma ultrafiltrate by graphite-furnace atomic-absorption spectrometry.
Analytical and bioanalytical chemistry 2005;382(7):1484-90.
2005: Isa E L M Kuppens; Maria J van Maanen; Hilde Rosing; J H M Schellens; Jos H Beijnen
Quantitative analysis of docetaxel in human plasma using liquid chromatography coupled with tandem mass spectrometry.
Biomedical chromatography : BMC 2005;19(5):355-61.
2005: L H H Silvertand; F Vazvaei; P Weigl; Hilde Rosing; Michel J X Hillebrand; Maria J van Maanen; Jos H Beijnen
Simultaneous quantification of fludarabine and cyclophosphamide in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM 2005;19(24):3673-80.
2005: Natalie M G M Appels; Maria J van Maanen; Hilde Rosing; Jan H M Schellens; Jos H Beijnen
Quantitative analysis of the farnesyl transferase inhibitor lonafarnib (Sarasartrade mark, SCH66336) in human plasma using high-performance liquid chromatography coupled with tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM 2005;19(15):2187-92.
2005: Ellen Stokvis; Hilde Rosing; Jos H Beijnen
Stable isotopically labeled internal standards in quantitative bioanalysis using liquid chromatography/mass spectrometry: necessity or not?
Rapid communications in mass spectrometry : RCM 2005;19(3):401-7.
2005: Isa E L M Kuppens; Tessa M Bosch; Maria J van Maanen; Hilde Rosing; A Fitzpatrick; Jos H Beijnen; J H M Schellens
Oral bioavailability of docetaxel in combination with OC144-093 (ONT-093).
Cancer chemotherapy and pharmacology 2005;55(1):72-8.
2004: Ellen Stokvis; Mariët Ouwehand; L G A H Nan; E Marleen Kemper; Olaf van Tellingen; Hilde Rosing; Jos H Beijnen
A simple and sensitive assay for the quantitative analysis of paclitaxel in human and mouse plasma and brain tumor tissue using coupled liquid chromatography and tandem mass spectrometry.
Journal of mass spectrometry : JMS 2004;39(12):1506-12.
2004: Ellen Stokvis; Hilde Rosing; Roger C Causon; Jan H M Schellens; Jos H Beijnen
Quantitative analysis of the P-glycoprotein inhibitor Elacridar (GF120918) in human and dog plasma using liquid chromatography with tandem mass spectrometric detection.
Journal of mass spectrometry : JMS 2004;39(10):1122-30.
2004: Ellen Stokvis; Hilde Rosing; Luis López-Lázaro; Jan H M Schellens; Jos H Beijnen
A more sensitive MS detector does not obviously lead to a more sensitive assay: experiences with ES-285.
Biomedical chromatography : BMC 2004;18(6):403-7.
2004: Ellen Stokvis; Hilde Rosing; Luis López-Lázaro; J H M Schellens; Jos H Beijnen
Switching from an analogous to a stable isotopically labeled internal standard for the LC-MS/MS quantitation of the novel anticancer drug Kahalalide F significantly improves assay performance.
Biomedical chromatography : BMC 2004;18(6):400-2.
2004: Thomas Kerbusch; Gerard Groenewegen; Ron A A Mathôt; Virginie M M Herben; Wim W ten Bokkel Huinink; M Swart; B Ambaum; Hilde Rosing; Sindy Jansen; Emile E Voest; Jos H Beijnen; J H M Schellens
Phase I and pharmacokinetic study of the combination of topotecan and ifosfamide administered intravenously every 3 weeks.
British journal of cancer 2004;90(12):2268-77.
2004: Kristel M L Crommentuyn; Hilde Rosing; Michel J X Hillebrand; Alwin D R Huitema; Jos H Beijnen
Simultaneous quantification of the new HIV protease inhibitors atazanavir and tipranavir in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;804(2):359-67.
2004: Ellen Stokvis; Hilde Rosing; Luis López-Lázaro; Jos H Beijnen
Simple and sensitive liquid chromatographic quantitative analysis of the novel marine anticancer drug Yondelis (ET-743, trabectedin) in human plasma using column switching and tandem mass spectrometric detection.
Journal of mass spectrometry : JMS 2004;39(4):431-6.
2004: Milly E De Jonge; H J G Desirée van den Bongard; Alwin D R Huitema; Ron A A Mathôt; Hilde Rosing; Paul Baas; nico van zandwijk; Jos H Beijnen; Jan H M Schellens
Bayesian pharmacokinetically guided dosing of paclitaxel in patients with non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(7):2237-44.
2004: Ellen Stokvis; Hilde Rosing; Mirjam Crul; M J Rieser; albert heck; J H M Schellens; Jos H Beijnen
Quantitative analysis of the novel anticancer drug ABT-518, a matrix metalloproteinase inhibitor, plus the screening of six metabolites in human plasma using high-performance liquid chromatography coupled with electrospray tandem mass spectrometry.
Journal of mass spectrometry : JMS 2004;39(3):277-88.
2004: Milly E De Jonge; Selma M Van Dam; Michel J X Hillebrand; Hilde Rosing; Alwin D R Huitema; Sjoerd Rodenhuis; Jos H Beijnen
Simultaneous quantification of cyclophosphamide, 4-hydroxycyclophosphamide, N,N',N"-triethylenethiophosphoramide (thiotepa) and N,N',N"-triethylenephosphoramide (tepa) in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.
Journal of mass spectrometry : JMS 2004;39(3):262-71.
2004: Jan-Hendrik Beumer; Hilde Rosing; Michel J X Hillebrand; Lianda G A H Nan-Offeringa; Karen Foley; S Murray Yule; albert heck; Jan H M Schellens; Jos H Beijnen
Quantitative determination of the novel anticancer drug E7070 (indisulam) and its metabolite (1,4-benzenedisulphonamide) in human plasma, urine and faeces by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM 2004;18(23):2839-48.
2004: Ellen Stokvis; Lianda G A H Nan-Offeringa; Mariët Ouwehand; Matthijs M Tibben; Hilde Rosing; Yvonne Schnaars; Martina Grigat; Peter Romeis; Jan H M Schellens; Jos H Beijnen
Quantitative analysis of D-24851, a novel anticancer agent, in human plasma and urine by liquid chromatography coupled with tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM 2004;18(13):1465-71.
2004: H J G Desirée van den Bongard; E Marleen Kemper; Olaf van Tellingen; Hilde Rosing; Ron A A Mathôt; Jan H M Schellens; Jos H Beijnen
Development and validation of a method to determine the unbound paclitaxel fraction in human plasma.
Analytical biochemistry 2004;324(1):11-5.
2003: Bregt S Kappelhoff; Hilde Rosing; Alwin D R Huitema; Jos H Beijnen
Simple and rapid method for the simultaneous determination of the non-nucleoside reverse transcriptase inhibitors efavirenz and nevirapine in human plasma using liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;792(2):353-62.
2003: Ellen Stokvis; Lianda G A H Nan-Offeringa; Hilde Rosing; Luis López-Lázaro; J L Aceña; Elena Miranda; Aleksander V. Lyubimov; B S Levine; C D'Aleo; J H M Schellens; Jos H Beijnen
Quantitative analysis of ES-285, an investigational marine anticancer drug, in human, mouse, rat, and dog plasma using coupled liquid chromatography and tandem mass spectrometry.
Journal of mass spectrometry : JMS 2003;38(5):548-54.
2003: Kristel M L Crommentuyn; Hilde Rosing; Lianda G A H Nan-Offeringa; Michel J X Hillebrand; Alwin D R Huitema; Jos H Beijnen
Rapid quantification of HIV protease inhibitors in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.
Journal of mass spectrometry : JMS 2003;38(2):157-66.
2003: C M F Kruijtzer; Henk Boot; Jos H Beijnen; H L Lochs; F X Parnis; A S T Planting; J M G Pelgrims; R Williams; Ron A A Mathôt; Hilde Rosing; Margaret Schot; Harm van Tinteren; J H M Schellens
Weekly oral paclitaxel as first-line treatment in patients with advanced gastric cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2003;14(2):197-204.
2003: Nadja E Schoemaker; Hilde Rosing; Sindy Jansen; Jan H M Schellens; Jos H Beijnen
High-performance liquid chromatographic analysis of the anticancer drug irinotecan (CPT-11) and its active metabolite SN-38 in human plasma.
Therapeutic drug monitoring 2003;25(1):120-4.
2002: C M F Kruijtzer; J H M Schellens; J Mezger; M E Scheulen; U Keilholz; Jos H Beijnen; Hilde Rosing; Ron A A Mathôt; S Marcus; Harm van Tinteren; Paul Baas
Phase II and pharmacologic study of weekly oral paclitaxel plus cyclosporine in patients with advanced non-small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(23):4508-16.
2002: Nadja E Schoemaker; Ron A A Mathôt; Patrick Schöffski; Hilde Rosing; Jan H M Schellens; Jos H Beijnen
Development of an optimal pharmacokinetic sampling schedule for rubitecan administered orally in a daily times five schedule.
Cancer chemotherapy and pharmacology 2002;50(6):514-7.
2002: Mirjam Crul; Laurens V Beerepoot; Ellen Stokvis; Johannes S P Vermaat; Hilde Rosing; Jos H Beijnen; Emile E Voest; Jan H M Schellens
Clinical pharmacokinetics, pharmacodynamics and metabolism of the novel matrix metalloproteinase inhibitor ABT-518.
Cancer chemotherapy and pharmacology 2002;50(6):473-8.
2002: johan jonker; Marije Buitelaar; Els Wagenaar; Martin van der Valk; George L Scheffer; Rik J Scheper; Torsten Plosch; Folkert Kuipers; Ronald P J Oude Elferink; Hilde Rosing; Jos H Beijnen; Alfred H Schinkel
The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(24):15649-54.
2002: Nadja E Schoemaker; Charlotte van Kesteren; Hilde Rosing; Sindy Jansen; M Swart; J Lieverst; Daniela Fraier; Massimo Breda; Cinzia Pellizzoni; Riccardo Spinelli; M Grazia Porro; Jos H Beijnen; J H M Schellens; Wim W ten Bokkel Huinink
A phase I and pharmacokinetic study of MAG-CPT, a water-soluble polymer conjugate of camptothecin.
British journal of cancer 2002;87(6):608-14.
2002: H J G Desirée van sen Bongard; Dick Pluim; Hilde Rosing; Lianda G A H Nan-Offeringa; Margaret Schot; Miroslav Ravic; Jan H M Schellens; Jos H Beijnen
An excretion balance and pharmacokinetic study of the novel anticancer agent E7070 in cancer patients.
Anti-cancer drugs 2002;13(8):807-14.
2002: Ellen Stokvis; Hilde Rosing; Luis López-Lázaro; I Rodriguez; José Jimeno; J G Supko; J H M Schellens; Jos H Beijnen
Quantitative analysis of the novel depsipeptide anticancer drug Kahalalide F in human plasma by high-performance liquid chromatography under basic conditions coupled to electrospray ionization tandem mass spectrometry.
Journal of mass spectrometry : JMS 2002;37(9):992-1000.
2002: Nadja E Schoemaker; Hilde Rosing; Sindy Jansen; Patrick Schöffski; Jinee Rizzo; Jan H M Schellens; Jos H Beijnen
Determination of 9-nitrocamptothecin and its metabolite 9-aminocamptothecin in human plasma using high-performance liquid chromatography with ultraviolet and fluorescence detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2002;775(2):231-7.
2002: Mirjam Crul; Hilde Rosing; GJ de Klerk; Ria Dubbelman; M Traiser; S Reichert; N G Knebel; J H M Schellens; Jos H Beijnen; Wim W ten Bokkel Huinink
Phase I and pharmacological study of daily oral administration of perifosine (D-21266) in patients with advanced solid tumours.
European journal of cancer (Oxford, England : 1990) 2002;38(12):1615-21.
2002: Virginie M M Herben; nadja E Schoemaker; Hilde Rosing; Desiree M van Zomeren; Wim W ten Bokkel Huinink; Ria Dubbelman; Solange Hearn; Jan H M Schellens; Jos H Beijnen
Urinary and fecal excretion of topotecan in patients with malignant solid tumours.
Cancer chemotherapy and pharmacology 2002;50(1):59-64.
2002: C M F Kruijtzer; Jos H Beijnen; Hilde Rosing; Wim W ten Bokkel Huinink; Margaret Schot; Roxanne C Jewell; Elaine M Paul; J H M Schellens
Increased oral bioavailability of topotecan in combination with the breast cancer resistance protein and P-glycoprotein inhibitor GF120918.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(13):2943-50.
2002: Charlotte van Kesteren; Chris Twelves; Adrian Bowman; Klaas Hoekman; Luis López-Lázaro; José Jimeno; Cecilia Guzman; Ron A A Mathôt; Andrew Simpson; Jan B Vermorken; John Smyth; Jan H M Schellens; Michel J X Hillebrand; Hilde Rosing; Jos H Beijnen
Clinical pharmacology of the novel marine-derived anticancer agent Ecteinascidin 743 administered as a 1- and 3-h infusion in a phase I study.
Anti-cancer drugs 2002;13(4):381-93.
2002: Mirjam Crul; Ron A A Mathôt; Giuseppe Giaccone; Cornelis A Punt; Hilde Rosing; Michel X Hillebrand; Yoshitaka Ando; Nobosuke Nishi; Hideji Tanaka; Jan M Schellens; Jos H Beijnen
Population pharmacokinetics of the novel anticancer agent KRN7000.
Cancer chemotherapy and pharmacology 2002;49(4):287-93.
2002: Miguel A Villalona-Calero; S Gail Eckhardt; Geoffrey Weiss; Manuel Hidalgo; Jos H Beijnen; Charlotte van Kesteren; Hilde Rosing; Elizabeth Campbell; Maura Kraynak; Luis Lopez-Lazaro; Cecilia Guzman; Daniel Von Hoff; José Jimeno; Eric K Rowinsky
A phase I and pharmacokinetic study of ecteinascidin-743 on a daily x 5 schedule in patients with solid malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(1):75-85.
2001: Charlotte van Kesteren; R A Mathĵt; Luis López-Lázaro; Esteban Cvitkovic; Abdelkrim Taamma; José Jimeno; Cecilia Guzman; J H M Schellens; Jean-Louis Misset; Etienne Brain; Michel J X Hillebrand; Hilde Rosing; Jos H Beijnen
A comparison of limited sampling strategies for prediction of Ecteinascidin 743 clearance when administered as a 24-h infusion.
Cancer chemotherapy and pharmacology 2001;48(6):459-66.
2001: Mirte M Malingré; J H M Schellens; Olaf van Tellingen; Mariët Ouwehand; Heleen A Bardelmeijer; Hilde Rosing; FJ Koopman; Margaret Schot; Wim W ten Bokkel Huinink; Jos H Beijnen
The co-solvent Cremophor EL limits absorption of orally administered paclitaxel in cancer patients.
British journal of cancer 2001;85(10):1472-7.
2001: Nadja E Schoemaker; Enrico Frigerio; Daniela Fraier; J H M Schellens; Hilde Rosing; Sindy Jansen; Jos H Beijnen
High-performance liquid chromatographic analysis for the determination of a novel polymer-bound camptothecin derivative (MAG-camptothecin) and free camptothecin in human plasma.
Journal of chromatography. B, Biomedical sciences and applications 2001;763(1-2):173-83.
2001: Rolf W Sparidans; Hilde Rosing; Michel J X Hillebrand; Luis López-Lázaro; José Jimeno; Ignasio Manzanares; Charlotte van Kesteren; Esteban Cvitkovic; A T van Oosterom; J H M Schellens; Jos H Beijnen
Search for metabolites of ecteinascidin 743, a novel, marine-derived, anti-cancer agent, in man.
Anti-cancer drugs 2001;12(8):653-66.
2001: Mirte M Malingré; Jos H Beijnen; Hilde Rosing; FJ Koopman; Olaf van Tellingen; K Duchin; Wim W ten Bokkel Huinink; M Swart; J Lieverst; J H M Schellens
A phase I and pharmacokinetic study of bi-daily dosing of oral paclitaxel in combination with cyclosporin A.
Cancer chemotherapy and pharmacology 2001;47(4):347-54.
2001: Mirte M Malingré; Jos H Beijnen; Hilde Rosing; FJ Koopman; Olaf van Tellingen; K Duchin; Wim W ten Bokkel Huinink; M Swart; J Lieverst; J H M Schellens
The effect of different doses of cyclosporin A on the systemic exposure of orally administered paclitaxel.
Anti-cancer drugs 2001;12(4):351-8.
2001: Jetske M Meerum Terwogt; Wim W ten Bokkel Huinink; J H M Schellens; Margaret Schot; IA Mandjes; M G Zurlo; M Rocchetti; Hilde Rosing; FJ Koopman; Jos H Beijnen
Phase I clinical and pharmacokinetic study of PNU166945, a novel water-soluble polymer-conjugated prodrug of paclitaxel.
Anti-cancer drugs 2001;12(4):315-23.
2001: Abdelkrim Taamma; Jean-Louis Misset; M Riofrio; Cecilia Guzman; Etienne Brain; Luis Lopez-Lazaro; Hilde Rosing; José Jimeno; Esteban Cvitkovic
Phase I and pharmacokinetic study of ecteinascidin-743, a new marine compound, administered as a 24-hour continuous infusion in patients with solid tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2001;19(5):1256-65.
2001: Mirte M Malingré; Dick J Richel; Jos H Beijnen; Hilde Rosing; FJ Koopman; Wim W ten Bokkel Huinink; Margaret Schot; J H M Schellens
Coadministration of cyclosporine strongly enhances the oral bioavailability of docetaxel.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2001;19(4):1160-6.
2001: Mirte M Malingré; Jos H Beijnen; Hilde Rosing; FJ Koopman; Roxanne C Jewell; Elaine M Paul; Wim W ten Bokkel Huinink; J H M Schellens
Co-administration of GF120918 significantly increases the systemic exposure to oral paclitaxel in cancer patients.
British journal of cancer 2001;84(1):42-7.
2000: Charlotte van Kesteren; Esteban Cvitkovic; Abdelkrim Taamma; Luis López-Lázaro; José Jimeno; Cecilia Guzman; R A Math t; J H M Schellens; Jean-Louis Misset; Etienne Brain; Michel J X Hillebrand; Hilde Rosing; Jos H Beijnen
Pharmacokinetics and pharmacodynamics of the novel marine-derived anticancer agent ecteinascidin 743 in a phase I dose-finding study.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(12):4725-32.
2000: Mirte M Malingré; J H M Schellens; Olaf van Tellingen; Hilde Rosing; FJ Koopman; K Duchin; Wim W Ten Bokkel Huinink; M Swart; Jos H Beijnen
Metabolism and excretion of paclitaxel after oral administration in combination with cyclosporin A and after i.v. administration.
Anti-cancer drugs 2000;11(10):813-20.
2000: Heleen A Bardelmeijer; Jos H Beijnen; Kenneth Brouwer; Hilde Rosing; Willem Nooijen; J H M Schellens; Olaf van Tellingen
Increased oral bioavailability of paclitaxel by GF120918 in mice through selective modulation of P-glycoprotein.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(11):4416-21.
2000: Mirte M Malingré; JM Terwogt; Jos H Beijnen; Hilde Rosing; FJ Koopman; Olaf van Tellingen; K Duchin; Wim W Ten Bokkel Huinink; M Swart; J Lieverst; J H M Schellens
Phase I and pharmacokinetic study of oral paclitaxel.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(12):2468-75.
2000: Hilde Rosing; V Lustig; LJ van Warmerdam; manon huizing; Wim W ten Bokkel Huinink; J H M Schellens; Sjoerd Rodenhuis; A Bult; Jos H Beijnen
Pharmacokinetics and metabolism of docetaxel administered as a 1-h intravenous infusion.
Cancer chemotherapy and pharmacology 2000;45(3):213-8.
1999: Jetske M Meerum Terwogt; Mirte M Malingré; Jos H Beijnen; Wim W ten Bokkel Huinink; Hilde Rosing; FJ Koopman; Olaf van Tellingen; M Swart; J H M Schellens
Coadministration of oral cyclosporin A enables oral therapy with paclitaxel.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(11):3379-84.
1999: Virginie M M Herben; Hilde Rosing; Wim W ten Bokkel Huinink; Desiree M van Zomeren; Diane Batchelor; E Doyle; F D Beusenberg; Jos H Beijnen; J H M Schellens
Oral topotecan: bioavailablity and effect of food co-administration.
British journal of cancer 1999;80(9):1380-6.
1999: VR Panday; Wim W ten Bokkel Huinink; Jan B Vermorken; Hilde Rosing; FJ Koopman; M Swart; J H M Schellens; Jos H Beijnen
Pharmacokinetics of paclitaxel administered as a 3-hour or 96-hour infusion.
Pharmacological research : the official journal of the Italian Pharmacological Society 1999;40(1):67-74.
1999: Hilde Rosing; Desiree M van Zomeren; E Doyle; W W ten Bokkel; J H M Schellens; Auke Bult; Jos H Beijnen
Quantification of topotecan and its metabolite N-desmethyltopotecan in human plasma, urine and faeces by high-performance liquid chromatographic methods.
Journal of chromatography. B, Biomedical sciences and applications 1999;727(1-2):191-203.
1999: Virginie M M Herben; VR Panday; Dick J Richel; J H M Schellens; Nine van der Vange; Hilde Rosing; F D Beusenberg; Solange Hearn; E Doyle; Jos H Beijnen; Wim W ten Bokkel Huinink
Phase I and pharmacologic study of the combination of paclitaxel, cisplatin, and topotecan administered intravenously every 21 days as first-line therapy in patients with advanced ovarian cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1999;17(3):747-55.
1999: VR Nannan Panday; Ronald de Wit; Jan H Schornagel; Margaret Schot; Hilde Rosing; J Lieverst; Wim W ten Bokkel Huinink; J H M Schellens; Jos H Beijnen
Pharmacokinetics of paclitaxel administered in combination with cisplatin, etoposide and bleomycin in patients with advanced solid tumours.
Cancer chemotherapy and pharmacology 1999;44(4):349-53.
1999: Hilde Rosing; Wim W ten Bokkel Huinink; R van Gijn; R F Rombouts; Auke Bult; Jos H Beijnen
Comparative open, randomized, cross-over bioequivalence study of two intravenous dexrazoxane formulations (Cardioxane and ICRF-187) in patients with advanced breast cancer, treated with 5-fluorouracil-doxorubicin-cyclophosphamide (FDC).
European journal of drug metabolism and pharmacokinetics 1999;24(1):69-77.
1999: R van Gijn; Wim W ten Bokkel Huinink; Sjoerd Rodenhuis; Jan B Vermorken; Olaf van Tellingen; Hilde Rosing; LJ van Warmerdam; Jos H Beijnen
Topoisomerase I/II inhibitor intoplicine administered as a 24 h infusion: phase I and pharmacologic study.
Anti-cancer drugs 1999;10(1):17-23.
1998: Hilde Rosing; Michel J X Hillebrand; José Jimeno; A Gómez; Pablo Floriano; Glynn Faircloth; RE Henrar; Jan B Vermorken; Esteban Cvitkovic; Auke Bult; Jos H Beijnen
Quantitative determination of Ecteinascidin 743 in human plasma by miniaturized high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.
Journal of mass spectrometry : JMS 1998;33(11):1134-40.
1998: VR Panday; Wim W ten Bokkel Huinink; Hilde Rosing; FJ Koopman; Michel J X Hillebrand; Ria Dubbelman; Olaf van Tellingen; J H M Schellens; Jos H Beijnen
Phase I and pharmacologic study of weekly doxorubicin and 1 h infusional paclitaxel in patients with advanced breast cancer.
Anti-cancer drugs 1998;9(8):665-73.
1998: Hilde Rosing; Desiree M van Zomeren; E Doyle; Auke Bult; Jos H Beijnen
O-glucuronidation, a newly identified metabolic pathway for topotecan and N-desmethyl topotecan.
Anti-cancer drugs 1998;9(7):587-92.
1998: Hilde Rosing; Michel J X Hillebrand; José Jimeno; A Gómez; Pablo Floriano; Glynn Faircloth; L Cameron; RE Henrar; Jan B Vermorken; Auke Bult; Jos H Beijnen
Analysis of Ecteinascidin 743, a new potent marine-derived anticancer drug, in human plasma by high-performance liquid chromatography in combination with solid-phase extraction.
Journal of chromatography. B, Biomedical sciences and applications 1998;710(1-2):183-9.
1998: manon huizing; Hilde Rosing; F P Koopmans; Jos H Beijnen
Influence of Cremophor EL on the quantification of paclitaxel in plasma using high-performance liquid chromatography with solid-phase extraction as sample pretreatment.
Journal of chromatography. B, Biomedical sciences and applications 1998;709(1):161-5.
1998: J D Jonkman-de Vries; Hilde Rosing; Herre Talsma; RE Henrar; J Jantina Kettenes-van den Bosch; Auke Bult; Jos H Beijnen
Pharmaceutical development of a parenteral lyophilized formulation of the investigational antitumor neuropeptide antagonist [Arg6, D-Trp7,9, MePhe8]-Substance P [6-11].
Investigational new drugs 1998;16(2):99-111.
1997: brian e davies; E A Minthorn; M J Dennis; Hilde Rosing; Jos H Beijnen
The pharmacokinetics of topotecan and its carboxylate form following separate intravenous administration to the dog.
Pharmaceutical research 1997;14(10):1461-5.
1997: Hilde Rosing; V Lustig; F P Koopman; Wim W ten Bokkel Huinink; Jos H Beijnen
Bio-analysis of docetaxel and hydroxylated metabolites in human plasma by high-performance liquid chromatography and automated solid-phase extraction.
Journal of chromatography. B, Biomedical sciences and applications 1997;696(1):89-98.
1997: manon huizing; LJ van Warmerdam; Hilde Rosing; M C Schaefers; A Lai; TJ Helmerhorst; Cindy Veenhof; M J Birkhofer; Sjoerd Rodenhuis; Jos H Beijnen; Wim W ten Bokkel Huinink
Phase I and pharmacologic study of the combination paclitaxel and carboplatin as first-line chemotherapy in stage III and IV ovarian cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(5):1953-64.
1997: Hilde Rosing; Virginie M M Herben; D M van Gortel-van Zomeren; E Hop; J Jantina Kettenes-van den Bosch; Wim W ten Bokkel Huinink; Jos H Beijnen
Isolation and structural confirmation of N-desmethyl topotecan, a metabolite of topotecan.
Cancer chemotherapy and pharmacology 1997;39(6):498-504.
1997: manon huizing; G Giaccone; LJ van Warmerdam; Hilde Rosing; P J M Bakker; Jan B Vermorken; P E Postmus; nico van zandwijk; M G Koolen; Wim W ten Bokkel Huinink; W J van der Vijgh; F J Bierhorst; A Lai; Otilia Dalesio; HERBERT PINEDO; Cindy Veenhof; Jos H Beijnen
Pharmacokinetics of paclitaxel and carboplatin in a dose-escalating and dose-sequencing study in patients with non-small-cell lung cancer. The European Cancer Centre.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(1):317-29.
1996: Hilde Rosing; E Doyle; Jos H Beijnen
The impact of column temperature in the high performance liquid chromatographic analysis of topotecan in rat and dog plasma.
Journal of pharmaceutical and biomedical analysis 1996;15(2):279-86.
1996: J H M Schellens; Geert-Jan Creemers; Jos H Beijnen; Hilde Rosing; MM de Boer-Dennert; M McDonald; B Davies; Jaap Verweij
Bioavailability and pharmacokinetics of oral topotecan: a new topoisomerase I inhibitor.
British journal of cancer 1996;73(10):1268-71.
1996: LJ van Warmerdam; Geert-Jan Creemers; Sjoerd Rodenhuis; Hilde Rosing; MM de Boer-Dennert; J H M Schellens; Wim W ten Bokkel Huinink; brian e davies; R A Maes; Jaap Verweij; Jos H Beijnen
Pharmacokinetics and pharmacodynamics of topotecan given on a daily-times-five schedule in phase II clinical trials using a limited-sampling procedure.
Cancer chemotherapy and pharmacology 1996;38(3):254-60.
1995: manon huizing; Alex Sparreboom; Hilde Rosing; Olaf van Tellingen; HERBERT PINEDO; Jos H Beijnen
Quantification of paclitaxel metabolites in human plasma by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical applications 1995;674(2):261-8.
1995: J D Jonkman-De Vries; Hilde Rosing; RE Henrar; Auke Bult; Jos H Beijnen
The influence of formulation excipients on the stability of the novel antitumor agent carzelesin (U-80,244).
PDA journal of pharmaceutical science and technology / PDA 1995;49(6):283-8.
1995: manon huizing; Jan B Vermorken; Hilde Rosing; Wim W ten Bokkel Huinink; IA Mandjes; HERBERT PINEDO; Jos H Beijnen
Pharmacokinetics of paclitaxel and three major metabolites in patients with advanced breast carcinoma refractory to anthracycline therapy treated with a 3-hour paclitaxel infusion: a European Cancer Centre (ECC) trial.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1995;6(7):699-704.
1995: A R Wafelman; Y L Nortier; Hilde Rosing; H J Maessen; B G Taal; Cornelis A Hoefnagel; R A Maes; Jos H Beijnen
Renal excretion of meta-iodobenzylguanidine after therapeutic doses in cancer patients and its relation to dose and creatinine clearance.
Nuclear medicine communications 1995;16(9):767-72.
1995: LJ van Warmerdam; Wim W ten Bokkel Huinink; Sjoerd Rodenhuis; I Koier; brian e davies; Hilde Rosing; R A Maes; Jos H Beijnen
Phase I clinical and pharmacokinetic study of topotecan administered by a 24-hour continuous infusion.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1995;13(7):1768-76.
1995: Hilde Rosing; E Doyle; brian e davies; Jos H Beijnen
High-performance liquid chromatographic determination of the novel antitumour drug topotecan and topotecan as the total of the lactone plus carboxylate forms, in human plasma.
Journal of chromatography. B, Biomedical applications 1995;668(1):107-15.
1995: manon huizing; Hilde Rosing; FJ Koopman; A C Keung; HERBERT PINEDO; Jos H Beijnen
High-performance liquid chromatographic procedures for the quantitative determination of paclitaxel (Taxol) in human urine.
Journal of chromatography. B, Biomedical applications 1995;664(2):373-82.
1995: Cornelis H W Koks; Hilde Rosing; Pieter L Meenhorst; A Bult; Jos H Beijnen
High-performance liquid chromatographic determination of the antifungal drug fluconazole in plasma and saliva of human immunodeficiency virus-infected patients.
Journal of chromatography. B, Biomedical applications 1995;663(2):345-51.
1995: LJ van Warmerdam; Jaap Verweij; J H M Schellens; Hilde Rosing; brian e davies; MM de Boer-Dennert; R A Maes; Jos H Beijnen
Pharmacokinetics and pharmacodynamics of topotecan administered daily for 5 days every 3 weeks.
Cancer chemotherapy and pharmacology 1995;35(3):237-45.
1994: David Burger; Hilde Rosing; C H ten Napel; T Duyts; Pieter L Meenhorst; Jan W Mulder; Cornelis H W Koks; A Bult; Jos H Beijnen
Application of a radioimmunoassay for determination of levels of zalcitabine (ddC) in human plasma, urine, and cerebrospinal fluid.
Antimicrobial agents and chemotherapy 1994;38(12):2763-7.
1994: A R Wafelman; M C Konings; Hilde Rosing; Cornelis A Hoefnagel; B G Taal; R A Maes; Jos H Beijnen
High-performance liquid chromatographic determination of metaiodobenzylguanidine in whole blood and plasma of cancer patients.
Journal of pharmaceutical and biomedical analysis 1994;12(9):1173-9.
1994: LJ van Warmerdam; Jaap Verweij; Hilde Rosing; J H M Schellens; R A Maes; Jos H Beijnen
Limited sampling models for topotecan pharmacokinetics.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1994;5(3):259-64.
1993: David Burger; Hilde Rosing; FJ Koopman; P L Mennhorst; Jan W Mulder; A Bult; Jos H Beijnen
Determination of 3'-amino-3'-deoxythymidine, a cytotoxic metabolite of 3'-azido-3'-deoxythymidine, in human plasma by ion-pair high-performance liquid chromatography.
Journal of chromatography 1993;622(2):235-42.
1993: A R Wafelman; Y L Nortier; Hilde Rosing; Willy J M Underberg; R A Maes; Jos H Beijnen
High-performance liquid chromatographic determination of m-iodobenzylguanidine in urine of cancer patients.
Journal of chromatography 1993;622(1):71-7.
1993: R van Gijn; S Kuijs; Hilde Rosing; A C Dubbelman; Olaf van Tellingen; Wim W ten Bokkel Huinink; HERBERT PINEDO; Jos H Beijnen
Determination of intoplicine, a new antitumour drug, in human faeces by normal-phase high-performance liquid chromatography with fluorescence detection.
Journal of pharmaceutical and biomedical analysis 1993;11(11-12):1345-8.
1993: manon huizing; A C Keung; Hilde Rosing; V van der Kuij; Wim W ten Bokkel Huinink; IA Mandjes; A C Dubbelman; HERBERT PINEDO; Jos H Beijnen
Pharmacokinetics of paclitaxel and metabolites in a randomized comparative study in platinum-pretreated ovarian cancer patients.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1993;11(11):2127-35.
1993: Jaap Verweij; B Lund; Jos H Beijnen; A S T Planting; MM de Boer-Dennert; I Koier; Hilde Rosing; H Hansen
Phase I and pharmacokinetics study of topotecan, a new topoisomerase I inhibitor.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1993;4(8):673-8.
1993: Jos H Beijnen; Hilde Rosing; Wim W ten Bokkel Huinink; HERBERT PINEDO
High-performance liquid chromatographic analysis of the antitumour drug camptothecin and its lactone ring-opened form in rat plasma.
Journal of chromatography 1993;617(1):111-7.
1993: R van Gijn; Hilde Rosing; Wim W ten Bokkel Huinink; Olaf van Tellingen; Jan B Vermorken; A J Liefting; R Bruno; HERBERT PINEDO; Jos H Beijnen
Determination of intoplicine, a new antitumour drug, in human whole blood and plasma by normal-phase high-performance liquid chromatography with fluorescence detection.
Journal of chromatography 1993;614(2):299-306.
1992: David Burger; Hilde Rosing; R van Gijn; Pieter L Meenhorst; Olaf van Tellingen; Jos H Beijnen
Determination of stavudine, a new antiretroviral agent, in human plasma by reversed-phase high-performance liquid chromatography with ultraviolet detection.
Journal of chromatography 1992;584(2):239-47.
1991: Jos H Beijnen; Pieter L Meenhorst; R van Gijn; M Fromme; Hilde Rosing; Willy J M Underberg
HPLC determination of doxorubicin, doxorubicinol and four aglycone metabolites in plasma of AIDS patients.
Journal of pharmaceutical and biomedical analysis 1991;9(10-12):995-1002.