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Hilde Rosing

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Co-Publications
Name
147
Beijnen, Jos
47
Schellens, J H M
42
Schellens, Jan
32
ten Bokkel Huinink, Wim
23
Hillebrand, Michel
19
van Tellingen, Olaf
13
Stokvis, Ellen
13
Huitema, Alwin
13
Koopman, FJ
9
Jimeno, José
9
López-Lázaro, Luis
9
Schinkel, Alfred
9
Vermorken, Jan
8
PINEDO, HERBERT
8
Swart, M

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Publications

TOP 3
Damen Carola W N; Lagas Jurjen S; Rosing Hilde; Schellens Jan H M; Beijnen Jos H
The bioanalysis of vinorelbine and 4-O-deacetylvinorelbine in human and mouse plasma using high-performance liquid chromatography coupled with heated electrospray ionization tandem mass-spectrometry.
Damen Carola W N; Derissen Ellen J B; Schellens Jan H M; Rosing Hilde; Beijnen Jos H
The bioanalysis of the monoclonal antibody trastuzumab by high-performance liquid chromatography with fluorescence detection after immuno-affinity purification from human serum.
Lankheet A G; Hillebrand M J X; Langenberg M H G; Rosing H; Huitema A D R; Voest E E; Schellens J H M; Beijnen J H
A validated assay for the quantitative analysis of vatalanib in human EDTA plasma by liquid chromatography coupled with electrospray ionization tandem mass spectrometry.

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All Publications

2009: Damen Carola W N; Lagas Jurjen S; Rosing Hilde; Schellens Jan H M; Beijnen Jos H
The bioanalysis of vinorelbine and 4-O-deacetylvinorelbine in human and mouse plasma using high-performance liquid chromatography coupled with heated electrospray ionization tandem mass-spectrometry.
Biomedical chromatography : BMC 2009;23(12):1316-25.
2009: Damen Carola W N; Derissen Ellen J B; Schellens Jan H M; Rosing Hilde; Beijnen Jos H
The bioanalysis of the monoclonal antibody trastuzumab by high-performance liquid chromatography with fluorescence detection after immuno-affinity purification from human serum.
Journal of pharmaceutical and biomedical analysis 2009;50(5):861-6.
2009: Lankheet A G; Hillebrand M J X; Langenberg M H G; Rosing H; Huitema A D R; Voest E E; Schellens J H M; Beijnen J H
A validated assay for the quantitative analysis of vatalanib in human EDTA plasma by liquid chromatography coupled with electrospray ionization tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(29):3625-30.
2009: Damen Carola W N; Chen Weibin; Chakraborty Asish B; van Oosterhout Mike; Mazzeo Jeffrey R; Gebler John C; Schellens Jan H M; Rosing Hilde; Beijnen Jos H
Electrospray ionization quadrupole ion-mobility time-of-flight mass spectrometry as a tool to distinguish the lot-to-lot heterogeneity in N-glycosylation profile of the therapeutic monoclonal antibody trastuzumab.
Journal of the American Society for Mass Spectrometry 2009;20(11):2021-33.
2009: Jansen Robert S; Rosing Hilde; Schellens Jan H M; Beijnen Jos H
Simultaneous quantification of 2',2'-difluorodeoxycytidine and 2',2'-difluorodeoxyuridine nucleosides and nucleotides in white blood cells using porous graphitic carbon chromatography coupled with tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM 2009;23(19):3040-50.
2009: Jansen Robert S; Rosing Hilde; Schellens Jan H M; Beijnen Jos H
Protein versus DNA as a marker for peripheral blood mononuclear cell counting.
Analytical and bioanalytical chemistry 2009;395(3):863-7.
2009: Damen Carola W N; Speijer Han; Hermens Wim T; Schellens Jan H M; Rosing Hilde; Beijnen Jos H
The bioanalysis of trastuzumab in human serum using precipitate-enhanced ellipsometry.
Analytical biochemistry 2009;393(1):73-9.
2009: Teunissen S F; Rosing H; Koornstra R H T; Linn S C; Schellens J H M; Schinkel A H; Beijnen J H
Development and validation of a quantitative assay for the analysis of tamoxifen with its four main metabolites and the flavonoids daidzein, genistein and glycitein in human serum using liquid chromatography coupled with tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(24):2519-29.
2009: Damen Carola W N; de Groot Els R; Heij Marianne; Boss David S; Schellens Jan H M; Rosing Hilde; Beijnen Jos H; Aarden Lucien A
Development and validation of an enzyme-linked immunosorbent assay for the quantification of trastuzumab in human serum and plasma.
Analytical biochemistry 2009;391(2):114-20.
2009: Boss David S; Siegel-Lakhai Wandena S; van Egmond-Schoemaker Nadja E; Pluim Dick; Rosing Hilde; Ten Bokkel Huinink Wim W; Beijnen Jos H; Schellens Jan H M
Phase I pharmacokinetic and pharmacodynamic study of Carboplatin and topotecan administered intravenously every 28 days to patients with malignant solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(13):4475-83.
2009: Oostendorp Roos L; Huitema Alwin; Rosing Hilde; Jansen Robert S; Ter Heine Rob; Keessen Marianne; Beijnen Jos H; Schellens Jan H M
Coadministration of ritonavir strongly enhances the apparent oral bioavailability of docetaxel in patients with solid tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(12):4228-33.
2009: Damen Carola W N; Rosing Hilde; Schellens Jan H M; Beijnen Jos H
Application of dried blood spots combined with high-performance liquid chromatography coupled with electrospray ionisation tandem mass spectrometry for simultaneous quantification of vincristine and actinomycin-D.
Analytical and bioanalytical chemistry 2009;394(4):1171-82.
2009: Lagas Jurjen S; van Waterschoot Robert A B; van Tilburg Vicky A C J; Hillebrand Michel J; Lankheet Nienke; Rosing Hilde; Beijnen Jos H; Schinkel Alfred H
Brain accumulation of dasatinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by elacridar treatment.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(7):2344-51.
2009: Jansen Robert S; Rosing Hilde; Schellens Jan H M; Beijnen Jos H
Retention studies of 2'-2'-difluorodeoxycytidine and 2'-2'-difluorodeoxyuridine nucleosides and nucleotides on porous graphitic carbon: development of a liquid chromatography-tandem mass spectrometry method.
Journal of chromatography. A 2009;1216(15):3168-74.
2009: Oostendorp R L; Loftiss J; Goel S; Smith D A; Dar M M; Witteveen P O; Cohen R B; Lewis L D; Kurian S; Patnaik A; Rosing H; Beijnen J H; Voest E E; Burris H; J
Bioequivalence study of a new oral topotecan formulation, relative to the current topotecan formulation, in patients with advanced solid tumors.
International journal of clinical pharmacology and therapeutics 2009;47(3):195-206.
2009: Damen Carola W N; Israëls Trijn; Caron Huib N; Schellens Jan H M; Rosing Hilde; Beijnen Jos H
Validated assay for the simultaneous quantification of total vincristine and actinomycin-D concentrations in human EDTA plasma and of vincristine concentrations in human plasma ultrafiltrate by high-performance liquid chromatography coupled with tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM 2009;23(6):763-74.
2009: ter Heine R; Davids M; Rosing H; van Gorp E C M; Mulder J W; van der Heide Y T; Beijnen J H; Huitema A D R
Quantification of HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors in peripheral blood mononuclear cell lysate using liquid chromatography coupled with tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2009;877(5-6):575-80.
2009: Ter Heine R; Rosing H; van Gorp E C M; Mulder J W; Beijnen J H; Huitema A D R
Quantification of etravirine (TMC125) in plasma, dried blood spots and peripheral blood mononuclear cell lysate by liquid chromatography tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis 2009;49(2):393-400.
2008: Veltkamp Stephan A; Jansen Robert S; Callies Sophie; Pluim Dick; Visseren-Grul Carla M; Rosing Hilde; Kloeker-Rhoades Susanne; Andre Valerie A M; Beijnen Jos H; Slapak Christopher A; Schellens Jan H M
Oral administration of gemcitabine in patients with refractory tumors: a clinical and pharmacologic study.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(11):3477-86.
2008: Damen Carola W N; Rosing Hilde; Tibben Matthijs M; van Maanen Maria J; Lagas Jurjen S; Schinkel Alfred H; Schellens Jan H M; Beijnen Jos H
A sensitive assay for the quantitative analysis of vinorelbine in mouse and human EDTA plasma by high-performance liquid chromatography coupled with electrospray tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;868(1-2):102-9.
2008: ter Heine R; Rosing H; van Gorp E C M; Mulder J W; van der Steeg W A; Beijnen J H; Huitema A D R
Quantification of protease inhibitors and non-nucleoside reverse transcriptase inhibitors in dried blood spots by liquid chromatography-triple quadrupole mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;867(2):205-12.
2008: Dorlo Thomas P C; Hillebrand Michel J X; Rosing Hilde; Eggelte Teunis A; de Vries Peter J; Beijnen Jos H
Development and validation of a quantitative assay for the measurement of miltefosine in human plasma by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2008;865(1-2):55-62.
2008: Brouwers Elke E M; Tibben Matthijs; Rosing H; Schellens Jan H M; Beijnen Jos H
The application of inductively coupled plasma mass spectrometry in clinical pharmacological oncology research.
Mass spectrometry reviews 2008;27(2):67-100.
2008: Damen Carola W N; Rosing Hilde; Schellens Jan H M; Beijnen Jos H
Quantitative aspects of the analysis of the monoclonal antibody trastuzumab using high-performance liquid chromatography coupled with electrospray mass spectrometry.
Journal of pharmaceutical and biomedical analysis 2008;46(3):449-55.
2008: Vainchtein Liia D; Rosing Hilde; Mirejovsky Dorla; Huynh Van; Lenaz Luigi; Schellens Jan H M; Beijnen Jos H
Enhanced resolution triple-quadrupole mass spectrometry for ultra-sensitive and quantitative analysis of the investigational anticancer agent EO9 (apaziquone) and its metabolite EO5a in human and dog plasma to support (pre)-clinical studies of EOquin given intravesically.
Rapid communications in mass spectrometry : RCM 2008;22(4):462-70.
2007: van Herwaarden Antonius E; Wagenaar Els; van der Kruijssen Cornelia M M; van Waterschoot Robert A B; Smit Johan W; Song Ji-Ying; van der Valk Martin A; van Tellingen Olaf; van der Hoorn José W A; Rosing Hilde; Beijnen Jos H; Schinkel Alfred H
Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism.
The Journal of clinical investigation 2007;117(11):3583-92.
2007: Joerger M; Huitema A D R; Huizing M T; Willemse P H B; de Graeff A; Rosing H; Schellens J H M; Beijnen J H; Vermorken J B
Safety and pharmacology of paclitaxel in patients with impaired liver function: a population pharmacokinetic-pharmacodynamic study.
British journal of clinical pharmacology 2007;64(5):622-33.
2007: Veltkamp S A; Rosing H; Huitema A D R; Fetell M R; Nol A; Beijnen J H; Schellens J H M
Novel paclitaxel formulations for oral application: a phase I pharmacokinetic study in patients with solid tumours.
Cancer chemotherapy and pharmacology 2007;60(5):635-42.
2007: Vainchtein Liia D; Rosing Hilde; Maier Armin; Fiebig Heinz-Herbert; Schellens Jan H M; Beijnen Jos H
Quantitative and selective assay of 5-methylindirubine, an inhibitor of cyclin-dependent kinases, in murine plasma using coupled liquid chromatography and electrospray tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;856(1-2):261-6.
2007: Ekhart Corine; Gebretensae Abadi; Rosing Hilde; Rodenhuis Sjoerd; Beijnen Jos H; Huitema Alwin D R
Simultaneous quantification of cyclophosphamide and its active metabolite 4-hydroxycyclophosphamide in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (LC-MS/MS).
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2007;854(1-2):345-9.
2007: Jonker Johan W; Musters Sandra; Vlaming Maria L H; Plösch Torsten; Gooijert Karin E R; Hillebrand Michel J; Rosing Hilde; Beijnen Jos H; Verkade Henkjan J; Schinkel Alfred H
Breast cancer resistance protein (Bcrp1/Abcg2) is expressed in the harderian gland and mediates transport of conjugated protoporphyrin IX.
American journal of physiology. Cell physiology 2007;292(6):C2204-12.
2007: Beumer Jan H; Rademaker-Lakhai Jeany M; Rosing Hilde; Hillebrand Michel J X; Bosch Tessa M; Lopez-Lazaro Luis; Schellens Jan H M; Beijnen Jos H
Metabolism of trabectedin (ET-743, Yondelis) in patients with advanced cancer.
Cancer chemotherapy and pharmacology 2007;59(6):825-37.
2007: van Herwaarden Antonius E; Wagenaar Els; Merino Gracia; Jonker Johan W; Rosing Hilde; Beijnen Jos H; Schinkel Alfred H
Multidrug transporter ABCG2/breast cancer resistance protein secretes riboflavin (vitamin B2) into milk.
Molecular and cellular biology 2007;27(4):1247-53.
2007: Vainchtein Liia D; Rosing Hilde; Mirejovsky Dorla; Lenaz Luigi; Schellens Jan H M; Beijnen Jos H
Stability experiments in human urine with EO9 (apaziquone): a novel anticancer agent for the intravesical treatment of bladder cancer.
Journal of pharmaceutical and biomedical analysis 2007;43(1):285-92.
2007: Veltkamp S A; Alderden-Los C; Sharma A; Rosing H; Beijnen J H; Schellens J H M
A pharmacokinetic and safety study of a novel polymeric paclitaxel formulation for oral application.
Cancer chemotherapy and pharmacology 2007;59(1):43-50.
2007: Jansen Robert S; Rosing Hilde; de Wolf Cocky J F; Beijnen Jos H
Development and validation of an assay for the quantitative determination of cladribine nucleotides in MDCKII cells and culture medium using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM 2007;21(24):4049-59.
2007: ter Heine Rob; Alderden-Los Carolien G; Rosing Hilde; Hillebrand Michel J X; van Gorp Eric C M; Huitema Alwin D R; Beijnen Jos H
Fast and simultaneous determination of darunavir and eleven other antiretroviral drugs for therapeutic drug monitoring: method development and validation for the determination of all currently approved HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors in human plasma by liquid chromatography coupled with electrospray ionization tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM 2007;21(15):2505-14.
2007: Vainchtein Liia D; Rosing Hilde; Thijssen Bas; Schellens Jan H M; Beijnen Jos H
Validated assay for the simultaneous determination of the anti-cancer agent gemcitabine and its metabolite 2',2'-difluorodeoxyuridine in human plasma by high-performance liquid chromatography with tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM 2007;21(14):2312-22.
2007: Brouwers Elke E M; Tibben Matthijs M; Rosing Hilde; Schellens Jan H M; Beijnen Jos H
Determination of ruthenium originating from the investigational anti-cancer drug NAMI-A in human plasma ultrafiltrate, plasma, and urine by inductively coupled plasma mass spectrometry.
Rapid communications in mass spectrometry : RCM 2007;21(9):1521-30.
2006: Veltkamp S A; Hillebrand M J X; Rosing H; Jansen R S; Wickremsinhe E R; Perkins E J; Schellens J H M; Beijnen J H
Quantitative analysis of gemcitabine triphosphate in human peripheral blood mononuclear cells using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry.
Journal of mass spectrometry : JMS 2006;41(12):1633-42.
2006: Lagas Jurjen S; Vlaming Maria L; van Tellingen Olaf; Wagenaar Els; Jansen Robert S; Rosing Hilde; Beijnen Jos H; Schinkel Alfred H
Multidrug resistance protein 2 is an important determinant of paclitaxel pharmacokinetics.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(20 Pt 1):6125-32.
2006: Vainchtein Liia D; Rosing Hilde; Mirejovsky Dorla; Huynh Van; Lenaz Luigi; Hillebrand Michel J X; Schellens Jan H M; Beijnen Jos H
Quantitative analysis of EO9 (apaziquone) and its metabolite EO5a in human plasma by high-performance liquid chromatography under basic conditions coupled to electrospray tandem mass spectrometry.
Journal of mass spectrometry : JMS 2006;41(10):1268-76.
2006: Brouwers E E M; Tibben M M; Rosing H; Hillebrand M J X; Joerger M; Schellens J H M; Beijnen J H
Sensitive inductively coupled plasma mass spectrometry assay for the determination of platinum originating from cisplatin, carboplatin, and oxaliplatin in human plasma ultrafiltrate.
Journal of mass spectrometry : JMS 2006;41(9):1186-94.
2006: Vlaming M L H; Mohrmann K; Wagenaar E; de Waart D R; Elferink R P J Oude; Lagas J S; van Tellingen O; Vainchtein L D; Rosing H; Beijnen J H; Schellens J H M; Schinkel A H
Carcinogen and anticancer drug transport by Mrp2 in vivo: studies using Mrp2 (Abcc2) knockout mice.
The Journal of pharmacology and experimental therapeutics 2006;318(1):319-27.
2006: Appels Natalie M G M; Rosing Hilde; Stephens Trevor C; Hughes Andrew; Schellens Jan H M; Beijnen Jos H
Absolute quantification of farnesylated Ras levels in complex samples using liquid chromatography fractionation combined with tryptic digestion and electrospray tandem mass spectrometry.
Analytical biochemistry 2006;352(1):33-40.
2006: Appels Natalie M G M; Rosing Hilde; Stephens Trevor C; Schellens Jan H M; Beijnen Jos H
Quantification of farnesylmethylcysteine in lysates of peripheral blood mononuclear cells using liquid chromatography coupled with electrospray tandem mass spectrometry: pharmacodynamic assay for farnesyl transferase inhibitors.
Analytical chemistry 2006;78(8):2617-22.
2006: Appels Natalie M G M; Tung Kien-On; Rosing Hilde; Schellens Jan H M; Beijnen Jos H
A rapid and simple HPLC-UV method for the determination of inhibition characteristics of farnesyl transferase inhibitors.
Biomedical chromatography : BMC 2006;20(2):161-5.
2006: Vainchtein Liia D; Thijssen Bas; Stokvis Ellen; Rosing Hilde; Schellens Jan H M; Beijnen Jos H
A simple and sensitive assay for the quantitative analysis of paclitaxel and metabolites in human plasma using liquid chromatography/tandem mass spectrometry.
Biomedical chromatography : BMC 2006;20(1):139-48.
2005: Stokvis Ellen; Rosing Hilde; Beijnen Jos H
Liquid chromatography-mass spectrometry for the quantitative bioanalysis of anticancer drugs.
Mass spectrometry reviews 2005;24(6):887-917.
2005: Beumer J H; Rademaker-Lakhai J M; Rosing H; Lopez-Lazaro L; Beijnen J H; Schellens J H M
Trabectedin (Yondelis, formerly ET-743), a mass balance study in patients with advanced cancer.
Investigational new drugs 2005;23(5):429-36.
2005: Rook Elisabeth J; Hillebrand Michel J X; Rosing Hilde; van Ree Jan M; Beijnen Jos H
The quantitative analysis of heroin, methadone and their metabolites and the simultaneous detection of cocaine, acetylcodeine and their metabolites in human plasma by high-performance liquid chromatography coupled with tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2005;824(1-2):213-21.
2005: Beumer Jan-Hendrik; Hillebrand Michel J X; Pluim Dick; Rosing Hilde; Foley Karen; Yule S Murray; Schellens Jan H M; Beijnen Jos H
Human metabolism of [(14)C]indisulam following i.v. infusion in cancer patients.
Investigational new drugs 2005;23(4):317-30.
2005: Brouwers E E M; Tibben M M; Joerger M; van Tellingen O; Rosing H; Schellens J H M; Beijnen J H
Determination of oxaliplatin in human plasma and plasma ultrafiltrate by graphite-furnace atomic-absorption spectrometry.
Analytical and bioanalytical chemistry 2005;382(7):1484-90.
2005: Kuppens I E L M; van Maanen M J; Rosing H; Schellens J H M; Beijnen J H
Quantitative analysis of docetaxel in human plasma using liquid chromatography coupled with tandem mass spectrometry.
Biomedical chromatography : BMC 2005;19(5):355-61.
2005: Kuppens I E L M; Bosch T M; van Maanen M J; Rosing H; Fitzpatrick A; Beijnen J H; Schellens J H M
Oral bioavailability of docetaxel in combination with OC144-093 (ONT-093).
Cancer chemotherapy and pharmacology 2005;55(1):72-8.
2005: Silvertand L H H; Vazvaei F; Weigl P; Rosing H; Hillebrand M J X; van Maanen M J; Beijnen J H
Simultaneous quantification of fludarabine and cyclophosphamide in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM 2005;19(24):3673-80.
2005: Appels Natalie M G M; van Maanen Maria J; Rosing Hilde; Schellens Jan H M; Beijnen Jos H
Quantitative analysis of the farnesyl transferase inhibitor lonafarnib (Sarasartrade mark, SCH66336) in human plasma using high-performance liquid chromatography coupled with tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM 2005;19(15):2187-92.
2005: Stokvis Ellen; Rosing Hilde; Beijnen Jos H
Stable isotopically labeled internal standards in quantitative bioanalysis using liquid chromatography/mass spectrometry: necessity or not?
Rapid communications in mass spectrometry : RCM 2005;19(3):401-7.
2004: Stokvis E; Ouwehand M; Nan L G A H; Kemper E M; van Tellingen O; Rosing H; Beijnen J H
A simple and sensitive assay for the quantitative analysis of paclitaxel in human and mouse plasma and brain tumor tissue using coupled liquid chromatography and tandem mass spectrometry.
Journal of mass spectrometry : JMS 2004;39(12):1506-12.
2004: Stokvis Ellen; Rosing Hilde; Causon Roger C; Schellens Jan H M; Beijnen Jos H
Quantitative analysis of the P-glycoprotein inhibitor Elacridar (GF120918) in human and dog plasma using liquid chromatography with tandem mass spectrometric detection.
Journal of mass spectrometry : JMS 2004;39(10):1122-30.
2004: Stokvis Ellen; Rosing Hilde; López-Lázaro Luis; Schellens Jan H M; Beijnen Jos H
A more sensitive MS detector does not obviously lead to a more sensitive assay: experiences with ES-285.
Biomedical chromatography : BMC 2004;18(6):403-7.
2004: Stokvis E; Rosing H; López-Lázaro L; Schellens J H M; Beijnen J H
Switching from an analogous to a stable isotopically labeled internal standard for the LC-MS/MS quantitation of the novel anticancer drug Kahalalide F significantly improves assay performance.
Biomedical chromatography : BMC 2004;18(6):400-2.
2004: Kerbusch T; Groenewegen G; Mathôt R A A; Herben V M M; ten Bokkel Huinink W W; Swart M; Ambaum B; Rosing H; Jansen S; Voest E E; Beijnen J H; Schellens J H M
Phase I and pharmacokinetic study of the combination of topotecan and ifosfamide administered intravenously every 3 weeks.
British journal of cancer 2004;90(12):2268-77.
2004: Crommentuyn K M L; Rosing H; Hillebrand M J X; Huitema A D R; Beijnen J H
Simultaneous quantification of the new HIV protease inhibitors atazanavir and tipranavir in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2004;804(2):359-67.
2004: Stokvis E; Rosing H; López-Lázaro L; Beijnen J H
Simple and sensitive liquid chromatographic quantitative analysis of the novel marine anticancer drug Yondelis (ET-743, trabectedin) in human plasma using column switching and tandem mass spectrometric detection.
Journal of mass spectrometry : JMS 2004;39(4):431-6.
2004: de Jonge Milly E; van den Bongard H J G Desirée; Huitema Alwin D R; Mathôt Ron A A; Rosing Hilde; Baas Paul; van Zandwijk Nico; Beijnen Jos H; Schellens Jan H M
Bayesian pharmacokinetically guided dosing of paclitaxel in patients with non-small cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(7):2237-44.
2004: Stokvis E; Rosing H; Crul M; Rieser M J; Heck A J R; Schellens J H M; Beijnen J H
Quantitative analysis of the novel anticancer drug ABT-518, a matrix metalloproteinase inhibitor, plus the screening of six metabolites in human plasma using high-performance liquid chromatography coupled with electrospray tandem mass spectrometry.
Journal of mass spectrometry : JMS 2004;39(3):277-88.
2004: de Jonge Milly E; van Dam Selma M; Hillebrand Michel J X; Rosing Hilde; Huitema Alwin D R; Rodenhuis Sjoerd; Beijnen Jos H
Simultaneous quantification of cyclophosphamide, 4-hydroxycyclophosphamide, N,N',N"-triethylenethiophosphoramide (thiotepa) and N,N',N"-triethylenephosphoramide (tepa) in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.
Journal of mass spectrometry : JMS 2004;39(3):262-71.
2004: van den Bongard H J G Desirée; Kemper E Marleen; van Tellingen Olaf; Rosing Hilde; Mathôt Ron A A; Schellens Jan H M; Beijnen Jos H
Development and validation of a method to determine the unbound paclitaxel fraction in human plasma.
Analytical biochemistry 2004;324(1):11-5.
2004: Beumer Jan Hendrik; Rosing Hilde; Hillebrand Michel J X; Nan-Offeringa Lianda G A H; Foley Karen; Yule S Murray; Heck Albert J R; Schellens Jan H M; Beijnen Jos H
Quantitative determination of the novel anticancer drug E7070 (indisulam) and its metabolite (1,4-benzenedisulphonamide) in human plasma, urine and faeces by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM 2004;18(23):2839-48.
2004: Stokvis Ellen; Nan-Offeringa Lianda G A H; Ouwehand Mariët; Tibben Matthijs M; Rosing Hilde; Schnaars Yvonne; Grigat Martina; Romeis Peter; Schellens Jan H M; Beijnen Jos H
Quantitative analysis of D-24851, a novel anticancer agent, in human plasma and urine by liquid chromatography coupled with tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM 2004;18(13):1465-71.
2003: Kappelhoff Bregt S; Rosing Hilde; Huitema Alwin D R; Beijnen Jos H
Simple and rapid method for the simultaneous determination of the non-nucleoside reverse transcriptase inhibitors efavirenz and nevirapine in human plasma using liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;792(2):353-62.
2003: Stokvis E; Nan-Offeringa L; Rosing H; López-Lázaro L; Aceña J L; Miranda E; Lyubimov A; Levine B S; D'Aleo C; Schellens J H M; Beijnen J H
Quantitative analysis of ES-285, an investigational marine anticancer drug, in human, mouse, rat, and dog plasma using coupled liquid chromatography and tandem mass spectrometry.
Journal of mass spectrometry : JMS 2003;38(5):548-54.
2003: Crommentuyn K M L; Rosing H; Nan-Offeringa L G A H; Hillebrand M J X; Huitema A D R; Beijnen J H
Rapid quantification of HIV protease inhibitors in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.
Journal of mass spectrometry : JMS 2003;38(2):157-66.
2003: Kruijtzer C M F; Boot H; Beijnen J H; Lochs H L; Parnis F X; Planting A S T; Pelgrims J M G; Williams R; Mathôt R A A; Rosing H; Schot M E; Van Tinteren H; Schellens J H M
Weekly oral paclitaxel as first-line treatment in patients with advanced gastric cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2003;14(2):197-204.
2003: Schoemaker Nadja E; Rosing Hilde; Jansen Sindy; Schellens Jan H M; Beijnen Jos H
High-performance liquid chromatographic analysis of the anticancer drug irinotecan (CPT-11) and its active metabolite SN-38 in human plasma.
Therapeutic drug monitoring 2003;25(1):120-4.
2002: Kruijtzer C M F; Schellens J H M; Mezger J; Scheulen M E; Keilholz U; Beijnen J H; Rosing H; Mathôt R A A; Marcus S; van Tinteren H; Baas P
Phase II and pharmacologic study of weekly oral paclitaxel plus cyclosporine in patients with advanced non-small-cell lung cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(23):4508-16.
2002: Schoemaker Nadja E; Mathôt Ron A A; Schöffski Patrick; Rosing Hilde; Schellens Jan H M; Beijnen Jos H
Development of an optimal pharmacokinetic sampling schedule for rubitecan administered orally in a daily times five schedule.
Cancer chemotherapy and pharmacology 2002;50(6):514-7.
2002: Crul Mirjam; Beerepoot Laurens V; Stokvis Ellen; Vermaat Johannes S P; Rosing Hilde; Beijnen Jos H; Voest Emile E; Schellens Jan H M
Clinical pharmacokinetics, pharmacodynamics and metabolism of the novel matrix metalloproteinase inhibitor ABT-518.
Cancer chemotherapy and pharmacology 2002;50(6):473-8.
2002: Jonker Johan W; Buitelaar Marije; Wagenaar Els; Van Der Valk Martin A; Scheffer George L; Scheper Rik J; Plosch Torsten; Kuipers Folkert; Elferink Ronald P J Oude; Rosing Hilde; Beijnen Jos H; Schinkel Alfred H
The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(24):15649-54.
2002: van sen Bongard H J G Desirée; Pluim Dick; Rosing Hilde; Nan-Offeringa Lianda; Schot Margaret; Ravic Miroslav; Schellens Jan H M; Beijnen Jos H
An excretion balance and pharmacokinetic study of the novel anticancer agent E7070 in cancer patients.
Anti-cancer drugs 2002;13(8):807-14.
2002: Stokvis E; Rosing H; López-Lázaro L; Rodriguez I; Jimeno J M; Supko J G; Schellens J H M; Beijnen J H
Quantitative analysis of the novel depsipeptide anticancer drug Kahalalide F in human plasma by high-performance liquid chromatography under basic conditions coupled to electrospray ionization tandem mass spectrometry.
Journal of mass spectrometry : JMS 2002;37(9):992-1000.
2002: Schoemaker N E; van Kesteren C; Rosing H; Jansen S; Swart M; Lieverst J; Fraier D; Breda M; Pellizzoni C; Spinelli R; Grazia Porro M; Beijnen J H; Schellens J H M; ten Bokkel Huinink W W
A phase I and pharmacokinetic study of MAG-CPT, a water-soluble polymer conjugate of camptothecin.
British journal of cancer 2002;87(6):608-14.
2002: Crul M; Rosing H; de Klerk G J; Dubbelman R; Traiser M; Reichert S; Knebel N G; Schellens J H M; Beijnen J H; ten Bokkel Huinink W W
Phase I and pharmacological study of daily oral administration of perifosine (D-21266) in patients with advanced solid tumours.
European journal of cancer (Oxford, England : 1990) 2002;38(12):1615-21.
2002: Schoemaker Nadja E; Rosing Hilde; Jansen Sindy; Schöffski Patrick; Rizzo Jinee; Schellens Jan H M; Beijnen Jos H
Determination of 9-nitrocamptothecin and its metabolite 9-aminocamptothecin in human plasma using high-performance liquid chromatography with ultraviolet and fluorescence detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2002;775(2):231-7.
2002: Herben Virginie M M; Schoemaker nadja E; Rosing Hilde; van Zomeren Desiree M; ten Bokkel Huinink Wim W; Dubbelman Ria; Hearn Solange; Schellens Jan H M; Beijnen Jos H
Urinary and fecal excretion of topotecan in patients with malignant solid tumours.
Cancer chemotherapy and pharmacology 2002;50(1):59-64.
2002: Kruijtzer C M F; Beijnen J H; Rosing H; ten Bokkel Huinink W W; Schot M; Jewell R C; Paul E M; Schellens J H M
Increased oral bioavailability of topotecan in combination with the breast cancer resistance protein and P-glycoprotein inhibitor GF120918.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(13):2943-50.
2002: van Kesteren Charlotte; Twelves Chris; Bowman Angela; Hoekman Klaas; López-Lázaro Luis; Jimeno José; Guzman Cecilia; Mathôt Ron A A; Simpson Andrew; Vermorken Jan B; Smyth John; Schellens Jan H M; Hillebrand Michel J X; Rosing Hilde; Beijnen Jos H
Clinical pharmacology of the novel marine-derived anticancer agent Ecteinascidin 743 administered as a 1- and 3-h infusion in a phase I study.
Anti-cancer drugs 2002;13(4):381-93.
2002: Crul Mirjam; Mathôt Ron A; Giaccone Giuseppe; Punt Cornelis A; Rosing Hilde; Hillebrand Michel X; Ando Yoshitaka; Nishi Nobosuke; Tanaka Hideji; Schellens Jan M; Beijnen Jos H
Population pharmacokinetics of the novel anticancer agent KRN7000.
Cancer chemotherapy and pharmacology 2002;49(4):287-93.
2002: Villalona-Calero Miguel A; Eckhardt S Gail; Weiss Geoffrey; Hidalgo Manuel; Beijnen Jos H; van Kesteren Charlotte; Rosing Hilde; Campbell Elizabeth; Kraynak Maura; Lopez-Lazaro Luis; Guzman Cecilia; Von Hoff Daniel D; Jimeno Jose; Rowinsky Eric K
A phase I and pharmacokinetic study of ecteinascidin-743 on a daily x 5 schedule in patients with solid malignancies.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(1):75-85.
2001: van Kesteren C; Mathjt R A; López-Lázaro L; Cvitkovic E; Taamma A; Jimeno J M; Guzman C; Schellens J H; Misset J L; Brain E; Hillebrand M J; Rosing H; Beijnen J H
A comparison of limited sampling strategies for prediction of Ecteinascidin 743 clearance when administered as a 24-h infusion.
Cancer chemotherapy and pharmacology 2001;48(6):459-66.
2001: Malingré M M; Schellens J H; Van Tellingen O; Ouwehand M; Bardelmeijer H A; Rosing H; Koopman F J; Schot M E; Ten Bokkel Huinink W W; Beijnen J H
The co-solvent Cremophor EL limits absorption of orally administered paclitaxel in cancer patients.
British journal of cancer 2001;85(10):1472-7.
2001: Schoemaker N E; Frigerio E; Fraier D; Schellens J H; Rosing H; Jansen S; Beijnen J H
High-performance liquid chromatographic analysis for the determination of a novel polymer-bound camptothecin derivative (MAG-camptothecin) and free camptothecin in human plasma.
Journal of chromatography. B, Biomedical sciences and applications 2001;763(1-2):173-83.
2001: Sparidans R W; Rosing H; Hillebrand M J; López-Lázaro L; Jimeno J M; Manzanares I; van Kesteren C; Cvitkovic E; van Oosterom A T; Schellens J H; Beijnen J H
Search for metabolites of ecteinascidin 743, a novel, marine-derived, anti-cancer agent, in man.
Anti-cancer drugs 2001;12(8):653-66.
2001: Malingré M M; Beijnen J H; Rosing H; Koopman F J; van Tellingen O; Duchin K; Ten Bokkel Huinink W W; Swart M; Lieverst J; Schellens J H
A phase I and pharmacokinetic study of bi-daily dosing of oral paclitaxel in combination with cyclosporin A.
Cancer chemotherapy and pharmacology 2001;47(4):347-54.
2001: Malingré M M; Beijnen J H; Rosing H; Koopman F J; van Tellingen O; Duchin K; ten Bokkel Huinink W W; Swart M; Lieverst J; Schellens J H
The effect of different doses of cyclosporin A on the systemic exposure of orally administered paclitaxel.
Anti-cancer drugs 2001;12(4):351-8.
2001: Meerum Terwogt J M; ten Bokkel Huinink W W; Schellens J H; Schot M; Mandjes I A; Zurlo M G; Rocchetti M; Rosing H; Koopman F J; Beijnen J H
Phase I clinical and pharmacokinetic study of PNU166945, a novel water-soluble polymer-conjugated prodrug of paclitaxel.
Anti-cancer drugs 2001;12(4):315-23.
2001: Taamma A; Misset J L; Riofrio M; Guzman C; Brain E; Lopez Lazaro L; Rosing H; Jimeno J M; Cvitkovic E
Phase I and pharmacokinetic study of ecteinascidin-743, a new marine compound, administered as a 24-hour continuous infusion in patients with solid tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2001;19(5):1256-65.
2001: Malingré M M; Richel D J; Beijnen J H; Rosing H; Koopman F J; Ten Bokkel Huinink W W; Schot M E; Schellens J H
Coadministration of cyclosporine strongly enhances the oral bioavailability of docetaxel.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2001;19(4):1160-6.
2001: Malingré M M; Beijnen J H; Rosing H; Koopman F J; Jewell R C; Paul E M; Ten Bokkel Huinink W W; Schellens J H
Co-administration of GF120918 significantly increases the systemic exposure to oral paclitaxel in cancer patients.
British journal of cancer 2001;84(1):42-7.
2000: van Kesteren C; Cvitkovic E; Taamma A; López-Lázaro L; Jimeno J M; Guzman C; Math t R A; Schellens J H; Misset J L; Brain E; Hillebrand M J; Rosing H; Beijnen J H
Pharmacokinetics and pharmacodynamics of the novel marine-derived anticancer agent ecteinascidin 743 in a phase I dose-finding study.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(12):4725-32.
2000: Malingré M M; Schellens J H; van Tellingen O; Rosing H; Koopman F J; Duchin K; Huinink W W; Swart M; Beijnen J H
Metabolism and excretion of paclitaxel after oral administration in combination with cyclosporin A and after i.v. administration.
Anti-cancer drugs 2000;11(10):813-20.
2000: Bardelmeijer H A; Beijnen J H; Brouwer K R; Rosing H; Nooijen W J; Schellens J H; van Tellingen O
Increased oral bioavailability of paclitaxel by GF120918 in mice through selective modulation of P-glycoprotein.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(11):4416-21.
2000: Malingré M M; Terwogt J M; Beijnen J H; Rosing H; Koopman F J; van Tellingen O; Duchin K; Huinink W W; Swart M; Lieverst J; Schellens J H
Phase I and pharmacokinetic study of oral paclitaxel.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2000;18(12):2468-75.
2000: Rosing H; Lustig V; van Warmerdam L J; Huizing M T; ten Bokkel Huinink W W; Schellens J H; Rodenhuis S; Bult A; Beijnen J H
Pharmacokinetics and metabolism of docetaxel administered as a 1-h intravenous infusion.
Cancer chemotherapy and pharmacology 2000;45(3):213-8.
1999: Meerum Terwogt J M; Malingré M M; Beijnen J H; ten Bokkel Huinink W W; Rosing H; Koopman F J; van Tellingen O; Swart M; Schellens J H
Coadministration of oral cyclosporin A enables oral therapy with paclitaxel.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(11):3379-84.
1999: Herben V M; Rosing H; ten Bokkel Huinink W W; van Zomeren D M; Batchelor D; Doyle E; Beusenberg F D; Beijnen J H; Schellens J H
Oral topotecan: bioavailablity and effect of food co-administration.
British journal of cancer 1999;80(9):1380-6.
1999: Panday V R; ten Bokkel Huinink W W; Vermorken J B; Rosing H; Koopman F J; Swart M; Schellens J H; Beijnen J H
Pharmacokinetics of paclitaxel administered as a 3-hour or 96-hour infusion.
Pharmacological research : the official journal of the Italian Pharmacological Society 1999;40(1):67-74.
1999: Rosing H; van Zomeren D M; Doyle E; ten Bokkel W W; Schellens J H; Bult A; Beijnen J H
Quantification of topotecan and its metabolite N-desmethyltopotecan in human plasma, urine and faeces by high-performance liquid chromatographic methods.
Journal of chromatography. B, Biomedical sciences and applications 1999;727(1-2):191-203.
1999: Herben V M; Panday V R; Richel D J; Schellens J H; van der Vange N; Rosing H; Beusenberg F D; Hearn S; Doyle E; Beijnen J H; ten Bokkel Huinink W W
Phase I and pharmacologic study of the combination of paclitaxel, cisplatin, and topotecan administered intravenously every 21 days as first-line therapy in patients with advanced ovarian cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1999;17(3):747-55.
1999: Rosing H; ten Bokkel Huinink W W; van Gijn R; Rombouts R F; Bult A; Beijnen J H
Comparative open, randomized, cross-over bioequivalence study of two intravenous dexrazoxane formulations (Cardioxane and ICRF-187) in patients with advanced breast cancer, treated with 5-fluorouracil-doxorubicin-cyclophosphamide (FDC).
European journal of drug metabolism and pharmacokinetics 1999;24(1):69-77.
1999: van Gijn R; ten Bokkel Huinink W W; Rodenhuis S; Vermorken J B; van Tellingen O; Rosing H; van Warmerdam L J; Beijnen J H
Topoisomerase I/II inhibitor intoplicine administered as a 24 h infusion: phase I and pharmacologic study.
Anti-cancer drugs 1999;10(1):17-23.
1999: Nannan Panday V R; de Wit R; Schornagel J H; Schot M; Rosing H; Lieverst J; ten Bokkel Huinink W W; Schellens J H; Beijnen J H
Pharmacokinetics of paclitaxel administered in combination with cisplatin, etoposide and bleomycin in patients with advanced solid tumours.
Cancer chemotherapy and pharmacology 1999;44(4):349-53.
1998: Rosing H; Hillebrand M J; Jimeno J M; Gómez A; Floriano P; Faircloth G; Henrar R E; Vermorken J B; Cvitkovic E; Bult A; Beijnen J H
Quantitative determination of Ecteinascidin 743 in human plasma by miniaturized high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.
Journal of mass spectrometry : JMS 1998;33(11):1134-40.
1998: Panday V R; ten Bokkel Huinink W W; Rosing H; Koopman F J; Hillebrand M J; Dubbelman R C; van Tellingen O; Schellens J H; Beijnen J H
Phase I and pharmacologic study of weekly doxorubicin and 1 h infusional paclitaxel in patients with advanced breast cancer.
Anti-cancer drugs 1998;9(8):665-73.
1998: Rosing H; van Zomeren D M; Doyle E; Bult A; Beijnen J H
O-glucuronidation, a newly identified metabolic pathway for topotecan and N-desmethyl topotecan.
Anti-cancer drugs 1998;9(7):587-92.
1998: Rosing H; Hillebrand M J; Jimeno J M; Gómez A; Floriano P; Faircloth G; Cameron L; Henrar R E; Vermorken J B; Bult A; Beijnen J H
Analysis of Ecteinascidin 743, a new potent marine-derived anticancer drug, in human plasma by high-performance liquid chromatography in combination with solid-phase extraction.
Journal of chromatography. B, Biomedical sciences and applications 1998;710(1-2):183-9.
1998: Huizing M T; Rosing H; Koopmans F P; Beijnen J H
Influence of Cremophor EL on the quantification of paclitaxel in plasma using high-performance liquid chromatography with solid-phase extraction as sample pretreatment.
Journal of chromatography. B, Biomedical sciences and applications 1998;709(1):161-5.
1998: Jonkman-de Vries J D; Rosing H; Talsma H; Henrar R E; Kettenes-van den Bosch J J; Bult A; Beijnen J H
Pharmaceutical development of a parenteral lyophilized formulation of the investigational antitumor neuropeptide antagonist [Arg6, D-Trp7,9, MePhe8]-Substance P [6-11].
Investigational new drugs 1998;16(2):99-111.
1997: Davies B E; Minthorn E A; Dennis M J; Rosing H; Beijnen J H
The pharmacokinetics of topotecan and its carboxylate form following separate intravenous administration to the dog.
Pharmaceutical research 1997;14(10):1461-5.
1997: Rosing H; Lustig V; Koopman F P; ten Bokkel Huinink W W; Beijnen J H
Bio-analysis of docetaxel and hydroxylated metabolites in human plasma by high-performance liquid chromatography and automated solid-phase extraction.
Journal of chromatography. B, Biomedical sciences and applications 1997;696(1):89-98.
1997: Huizing M T; van Warmerdam L J; Rosing H; Schaefers M C; Lai A; Helmerhorst T J; Veenhof C H; Birkhofer M J; Rodenhuis S; Beijnen J H; ten Bokkel Huinink W W
Phase I and pharmacologic study of the combination paclitaxel and carboplatin as first-line chemotherapy in stage III and IV ovarian cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(5):1953-64.
1997: Huizing M T; Giaccone G; van Warmerdam L J; Rosing H; Bakker P J; Vermorken J B; Postmus P E; van Zandwijk N; Koolen M G; ten Bokkel Huinink W W; van der Vijgh W J; Bierhorst F J; Lai A; Dalesio O; Pinedo H M; Veenhof C H; Beijnen J H
Pharmacokinetics of paclitaxel and carboplatin in a dose-escalating and dose-sequencing study in patients with non-small-cell lung cancer. The European Cancer Centre.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1997;15(1):317-29.
1997: Rosing H; Herben V M; van Gortel-van Zomeren D M; Hop E; Kettenes-van den Bosch J J; ten Bokkel Huinink W W; Beijnen J H
Isolation and structural confirmation of N-desmethyl topotecan, a metabolite of topotecan.
Cancer chemotherapy and pharmacology 1997;39(6):498-504.
1996: Rosing H; Doyle E; Beijnen J H
The impact of column temperature in the high performance liquid chromatographic analysis of topotecan in rat and dog plasma.
Journal of pharmaceutical and biomedical analysis 1996;15(2):279-86.
1996: Schellens J H; Creemers G J; Beijnen J H; Rosing H; de Boer-Dennert M; McDonald M; Davies B; Verweij J
Bioavailability and pharmacokinetics of oral topotecan: a new topoisomerase I inhibitor.
British journal of cancer 1996;73(10):1268-71.
1996: van Warmerdam L J; Creemers G J; Rodenhuis S; Rosing H; de Boer-Dennert M; Schellens J H; ten Bokkel Huinink W W; Davies B E; Maes R A; Verweij J; Beijnen J H
Pharmacokinetics and pharmacodynamics of topotecan given on a daily-times-five schedule in phase II clinical trials using a limited-sampling procedure.
Cancer chemotherapy and pharmacology 1996;38(3):254-60.
1995: Huizing M T; Sparreboom A; Rosing H; van Tellingen O; Pinedo H M; Beijnen J H
Quantification of paclitaxel metabolites in human plasma by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical applications 1995;674(2):261-8.
1995: Jonkman-De Vries J D; Rosing H; Henrar R E; Bult A; Beijnen J H
The influence of formulation excipients on the stability of the novel antitumor agent carzelesin (U-80,244).
PDA journal of pharmaceutical science and technology / PDA 1995;49(6):283-8.
1995: Huizing M T; Vermorken J B; Rosing H; ten Bokkel Huinink W W; Mandjes I; Pinedo H M; Beijnen J H
Pharmacokinetics of paclitaxel and three major metabolites in patients with advanced breast carcinoma refractory to anthracycline therapy treated with a 3-hour paclitaxel infusion: a European Cancer Centre (ECC) trial.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1995;6(7):699-704.
1995: Wafelman A R; Nortier Y L; Rosing H; Maessen H J; Taal B G; Hoefnagel C A; Maes R A; Beijnen J H
Renal excretion of meta-iodobenzylguanidine after therapeutic doses in cancer patients and its relation to dose and creatinine clearance.
Nuclear medicine communications 1995;16(9):767-72.
1995: van Warmerdam L J; ten Bokkel Huinink W W; Rodenhuis S; Koier I; Davies B E; Rosing H; Maes R A; Beijnen J H
Phase I clinical and pharmacokinetic study of topotecan administered by a 24-hour continuous infusion.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1995;13(7):1768-76.
1995: Rosing H; Doyle E; Davies B E; Beijnen J H
High-performance liquid chromatographic determination of the novel antitumour drug topotecan and topotecan as the total of the lactone plus carboxylate forms, in human plasma.
Journal of chromatography. B, Biomedical applications 1995;668(1):107-15.
1995: Huizing M T; Rosing H; Koopman F; Keung A C; Pinedo H M; Beijnen J H
High-performance liquid chromatographic procedures for the quantitative determination of paclitaxel (Taxol) in human urine.
Journal of chromatography. B, Biomedical applications 1995;664(2):373-82.
1995: Koks C H; Rosing H; Meenhorst P L; Bult A; Beijnen J H
High-performance liquid chromatographic determination of the antifungal drug fluconazole in plasma and saliva of human immunodeficiency virus-infected patients.
Journal of chromatography. B, Biomedical applications 1995;663(2):345-51.
1995: van Warmerdam L J; Verweij J; Schellens J H; Rosing H; Davies B E; de Boer-Dennert M; Maes R A; Beijnen J H
Pharmacokinetics and pharmacodynamics of topotecan administered daily for 5 days every 3 weeks.
Cancer chemotherapy and pharmacology 1995;35(3):237-45.
1994: Burger D M; Rosing H; ten Napel C H; Duyts T; Meenhorst P L; Mulder J W; Koks C H; Bult A; Beijnen J H
Application of a radioimmunoassay for determination of levels of zalcitabine (ddC) in human plasma, urine, and cerebrospinal fluid.
Antimicrobial agents and chemotherapy 1994;38(12):2763-7.
1994: Wafelman A R; Konings M C; Rosing H; Hoefnagel C A; Taal B G; Maes R A; Beijnen J H
High-performance liquid chromatographic determination of metaiodobenzylguanidine in whole blood and plasma of cancer patients.
Journal of pharmaceutical and biomedical analysis 1994;12(9):1173-9.
1994: van Warmerdam L J; Verweij J; Rosing H; Schellens J H; Maes R A; Beijnen J H
Limited sampling models for topotecan pharmacokinetics.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1994;5(3):259-64.
1993: Burger D M; Rosing H; Koopman F J; Mennhorst P L; Mulder J W; Bult A; Beijnen J H
Determination of 3'-amino-3'-deoxythymidine, a cytotoxic metabolite of 3'-azido-3'-deoxythymidine, in human plasma by ion-pair high-performance liquid chromatography.
Journal of chromatography 1993;622(2):235-42.
1993: Wafelman A R; Nortier Y L; Rosing H; Underberg W J; Maes R A; Beijnen J H
High-performance liquid chromatographic determination of m-iodobenzylguanidine in urine of cancer patients.
Journal of chromatography 1993;622(1):71-7.
1993: van Gijn R; Kuijs S; Rosing H; Dubbelman A C; van Tellingen O; ten Bokkel Huinink W W; Pinedo H M; Beijnen J H
Determination of intoplicine, a new antitumour drug, in human faeces by normal-phase high-performance liquid chromatography with fluorescence detection.
Journal of pharmaceutical and biomedical analysis 1993;11(11-12):1345-8.
1993: Huizing M T; Keung A C; Rosing H; van der Kuij V; ten Bokkel Huinink W W; Mandjes I M; Dubbelman A C; Pinedo H M; Beijnen J H
Pharmacokinetics of paclitaxel and metabolites in a randomized comparative study in platinum-pretreated ovarian cancer patients.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1993;11(11):2127-35.
1993: Verweij J; Lund B; Beijnen J; Planting A; de Boer-Dennert M; Koier I; Rosing H; Hansen H
Phase I and pharmacokinetics study of topotecan, a new topoisomerase I inhibitor.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 1993;4(8):673-8.
1993: Beijnen J H; Rosing H; ten Bokkel Huinink W W; Pinedo H M
High-performance liquid chromatographic analysis of the antitumour drug camptothecin and its lactone ring-opened form in rat plasma.
Journal of chromatography 1993;617(1):111-7.
1993: van Gijn R; Rosing H; ten Bokkel Huinink W W; van Tellingen O; Vermorken J B; Liefting A J; Bruno R; Pinedo H M; Beijnen J H
Determination of intoplicine, a new antitumour drug, in human whole blood and plasma by normal-phase high-performance liquid chromatography with fluorescence detection.
Journal of chromatography 1993;614(2):299-306.
1992: Burger D M; Rosing H; van Gijn R; Meenhorst P L; van Tellingen O; Beijnen J H
Determination of stavudine, a new antiretroviral agent, in human plasma by reversed-phase high-performance liquid chromatography with ultraviolet detection.
Journal of chromatography 1992;584(2):239-47.
1991: Beijnen J H; Meenhorst P L; van Gijn R; Fromme M; Rosing H; Underberg W J
HPLC determination of doxorubicin, doxorubicinol and four aglycone metabolites in plasma of AIDS patients.
Journal of pharmaceutical and biomedical analysis 1991;9(10-12):995-1002.

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