FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Jan Rosing

Research Profile

Chemicals & Drugs

Disorders

Concepts & Ideas

Physiology

Procedures

Blood Coagulation Tests

Co-author Network

Publications

TOP 3
M Raps; Frits R Rosendaal; Jan Rosing; S Thomassen; B E P B Ballieux; Frans M Helmerhorst; H A A M Van Vliet
Resistance to APC and SHBG levels during use of a four-phasic oral contraceptive containing dienogest and estradiol valerate: a randomized controlled trial.
M Raps; Pieter H Reitsma; Frits R Rosendaal; Jan Rosing; Per Morten Sandset; Anders Dahm; K Fleischer; Frans M Helmerhorst; H A A M Van Vliet
The effect of different hormonal contraceptives on plasma levels of free protein S and free TFPI.
S Peraramelli; Jan Rosing; Friedrich Scheiflinger; S Thomassen; Tilman M Hackeng; R Hartmann; A Heinzmann; Michael Dockal
Direct inhibition of factor VIIa by TFPI and TFPI constructs.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Jan Rosing (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: M Raps; Frits R Rosendaal; Jan Rosing; S Thomassen; B E P B Ballieux; Frans M Helmerhorst; H A A M Van Vliet
Resistance to APC and SHBG levels during use of a four-phasic oral contraceptive containing dienogest and estradiol valerate: a randomized controlled trial.
Journal of thrombosis and haemostasis : JTH 2013;11(5):855-61.
2013: M Raps; Pieter H Reitsma; Frits R Rosendaal; Jan Rosing; Per Morten Sandset; Anders Dahm; K Fleischer; Frans M Helmerhorst; H A A M Van Vliet
The effect of different hormonal contraceptives on plasma levels of free protein S and free TFPI.
Thrombosis and haemostasis 2013;109(4):606-13.
2013: S Peraramelli; Jan Rosing; Friedrich Scheiflinger; S Thomassen; Tilman M Hackeng; R Hartmann; A Heinzmann; Michael Dockal
Direct inhibition of factor VIIa by TFPI and TFPI constructs.
Journal of thrombosis and haemostasis : JTH 2013;11(4):704-14.
2013: M Raps; F R Rosendaal; Jan Rosing; B H Stegeman; S Thomassen; V A Van Hylckama; B E P B Ballieux; K Fleischer; Frans M Helmerhorst; H A A M Van Vliet
Sex hormone-binding globulin as a marker for the thrombotic risk of hormonal contraceptives: reply to a rebuttal.
Journal of thrombosis and haemostasis : JTH 2013;11(2):396-7.
2012: Sameera Peraramelli; Jan Rosing; Dennis P L Suylen; Tilman M Hackeng
The Kunitz 1 and Kunitz 3 domains of tissue factor pathway inhibitor are required for efficient inhibition of factor Xa.
Thrombosis and haemostasis 2012;108(2):266-76.
2012: M Raps; Frits R Rosendaal; Jan Rosing; S Thomassen; B E P B Ballieux; K Fleischer; Frans M Helmerhorst; H A A M Van Vliet
Sex hormone-binding globulin as a marker for the thrombotic risk of hormonal contraceptives.
Journal of thrombosis and haemostasis : JTH 2012;10(6):992-7.
2012: O Segers; Paolo Simioni; Daniela Tormene; Cristiana Bulato; Sabrina Gavasso; Jan Rosing; Elisabetta Castoldi
Genetic modulation of the FV(Leiden)/normal FV ratio and risk of venous thrombosis in factor V Leiden heterozygotes.
Journal of thrombosis and haemostasis : JTH 2012;10(1):73-80.
2011: Heather K Kroh; Peter Panizzi; Jan Rosing; Guido Tans; Svetlana Tchaikovski; Nancy Wei; T Regan Baird; Bruce Furie; Barbara C Furie; Senthil Kumar Krishnaswamy; Paul E Bock
Active site-labeled prothrombin inhibits prothrombinase in vitro and thrombosis in vivo.
The Journal of biological chemistry 2011;286(26):23345-56.
2011: Elisabetta Castoldi; C Duckers; C Radu; Luca Spiezia; V Rossetto; G Tagariello; Jan Rosing; Paolo Simioni
Homozygous F5 deep-intronic splicing mutation resulting in severe factor V deficiency and undetectable thrombin generation in platelet-rich plasma.
Journal of thrombosis and haemostasis : JTH 2011;9(5):959-68.
2011: C Duckers; Paolo Simioni; Daniela Tormene; S Carraro; Jan Rosing; Elisabetta Castoldi
Factor V Leiden pseudo-homozygotes have a more pronounced hypercoagulable state than factor V Leiden homozygotes.
Journal of thrombosis and haemostasis : JTH 2011;9(4):864-7.
2011: M Smid; A W J H Dielis; M Winkens; Henri M H Spronk; René Van Oerle; Karly Hamulyák; Martin H Prins; Jan Rosing; J L Waltenberger; Hugo ten Cate
Thrombin generation in patients with a first acute myocardial infarction.
Journal of thrombosis and haemostasis : JTH 2011;9(3):450-6.
2011: Elisabetta Castoldi; Jan Rosing
Thrombin generation tests.
Thrombosis research 2011;127 Suppl 3():S21-5.
2010: Elisabetta Castoldi; Lisbeth F A Maurissen; Daniela Tormene; Luca Spiezia; Sabrina Gavasso; Claudia Radu; Tilman M Hackeng; Jan Rosing; Paolo Simioni
Similar hypercoagulable state and thrombosis risk in type I and type III protein S-deficient individuals from families with mixed type I/III protein S deficiency.
Haematologica 2010;95(9):1563-71.
2010: Svetlana N Tchaikovski; Jan Rosing
Mechanisms of estrogen-induced venous thromboembolism.
Thrombosis research 2010;126(1):5-11.
2010: Elisabetta Castoldi; Lisbeth F A Maurissen; Daniela Tormene; Luca Spiezia; Sabrina Gavasso; Claudia Radu; Tilman M Hackeng; Jan Rosing; Paolo Simioni
Similar hypercoagulable state and thrombosis risk in type I and type III protein S-deficient individuals from mixed type I/III families.
Haematologica 2010;():.
2010: L F A Maurissen; Elisabetta Castoldi; Paolo Simioni; Jan Rosing; Tilman M Hackeng
Thrombin generation-based assays to measure the activity of the TFPI-protein S pathway in plasma from normal and protein S-deficient individuals.
Journal of thrombosis and haemostasis : JTH 2010;8(4):750-8.
2010: Elisabetta Castoldi; Jan Rosing
APC resistance: biological basis and acquired influences.
Journal of thrombosis and haemostasis : JTH 2010;8(3):445-53.
2010: Elisabetta Castoldi; P Simioni; D Tormene; Jan Rosing; Tilman M Hackeng
Hereditary and acquired protein S deficiencies are associated with low TFPI levels in plasma.
Journal of thrombosis and haemostasis : JTH 2010;8(2):294-300.
2010: Connie Duckers; Paolo Simioni; Luca Spiezia; Claudia Radu; Paolo Dabrilli; Sabrina Gavasso; Jan Rosing; Elisabetta Castoldi
Residual platelet factor V ensures thrombin generation in patients with severe congenital factor V deficiency and mild bleeding symptoms.
Blood 2010;115(4):879-86.
2010: Olivier Segers; René Van Oerle; Hugo ten Cate; Jan Rosing; Elisabetta Castoldi
Thrombin generation as an intermediate phenotype for venous thrombosis.
Thrombosis and haemostasis 2010;103(1):114-22.
2009: Tilman M Hackeng; Jan Rosing
Protein S as cofactor for TFPI.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(12):2015-20.
2009: Tilman M Hackeng; L F A Maurissen; Elisabetta Castoldi; Jan Rosing
Regulation of TFPI function by protein S.
Journal of thrombosis and haemostasis : JTH 2009;7 Suppl 1():165-8.
2009: Connie Duckers; Paolo Simioni; Jan Rosing; Elisabetta Castoldi
Advances in understanding the bleeding diathesis in factor V deficiency.
British journal of haematology 2009;146(1):17-26.
2009: H A A M Van Vliet; Svetlana N Tchaikovski; Frits R Rosendaal; Jan Rosing; Frans M Helmerhorst
The effect of the levonorgestrel-releasing intrauterine system on the resistance to activated protein C (APC).
Thrombosis and haemostasis 2009;101(4):691-5.
2009: S N Tchaikovski; Bart J M van Vlijmen; A C A Cleuren; M Christella L G D Thomassen; V Tchaikovski; Guido Tans; Jan Rosing
Pregnancy-associated changes in the hemostatic system in wild-type and factor V Leiden mice.
Journal of thrombosis and haemostasis : JTH 2009;7(2):312-8.
2008: Marina Marchetti; Elisabetta Castoldi; Henri M H Spronk; René Van Oerle; Donatella Balducci; Tiziano Barbui; Jan Rosing; Hugo ten Cate; Anna Falanga
Thrombin generation and activated protein C resistance in patients with essential thrombocythemia and polycythemia vera.
Blood 2008;112(10):4061-8.
2008: Connie Duckers; Paolo Simioni; Luca Spiezia; Claudia Radu; Sabrina Gavasso; Jan Rosing; Elisabetta Castoldi
Low plasma levels of tissue factor pathway inhibitor in patients with congenital factor V deficiency.
Blood 2008;112(9):3615-23.
2008: Kenneth Segers; Björn Dahlbäck; Jan Rosing; Gerry A F Nicolaes
Identification of surface epitopes of human coagulation factor Va that are important for interaction with activated protein C and heparin.
The Journal of biological chemistry 2008;283(33):22573-81.
2008: Lisbeth F A Maurissen; M Christella L G D Thomassen; Gerry A F Nicolaes; Björn Dahlbäck; Guido Tans; Jan Rosing; Tilman M Hackeng
Re-evaluation of the role of the protein S-C4b binding protein complex in activated protein C-catalyzed factor Va-inactivation.
Blood 2008;111(6):3034-41.
2008: Julia V Johnson; Jane Lowell; Gary J Badger; Jan Rosing; Svetlana Tchaikovski; Mary Cushman
Effects of oral and transdermal hormonal contraception on vascular risk markers: a randomized controlled trial.
Obstetrics and gynecology 2008;111(2 Pt 1):278-84.
2008: H A A M Van Vliet; Rogier M Bertina; Anders Dahm; Frits R Rosendaal; Jan Rosing; Per Morten Sandset; Frans M Helmerhorst
Different effects of oral contraceptives containing different progestogens on protein S and tissue factor pathway inhibitor.
Journal of thrombosis and haemostasis : JTH 2008;6(2):346-51.
2008: Jan Rosing; L F A Maurissen; S N Tchaikovski; Guido Tans; Tilman M Hackeng
Protein S is a cofactor for tissue factor pathway inhibitor.
Thrombosis research 2008;122 Suppl 1():S60-3.
2008: Arne W J H Dielis; Elisabetta Castoldi; Henri M H Spronk; René Van Oerle; Karly Hamulyák; Hugo ten Cate; Jan Rosing
Coagulation factors and the protein C system as determinants of thrombin generation in a normal population.
Journal of thrombosis and haemostasis : JTH 2008;6(1):125-31.
2008: H A A M Van Vliet; Sharon P Rodrigues; Marieke N E Snieders; Felix J M van der Meer; Marijke Frolich; Frits R Rosendaal; Jan Rosing; Frans M Helmerhorst
Sensitivity to activated protein C during the menstrual cycle in women with and without factor VLeiden.
Thrombosis research 2008;121(6):757-61.
2007: Svetlana N Tchaikovski; H A A M Van Vliet; M C L G D Thomassen; Rogier M Bertina; Frits R Rosendaal; Per Morten Sandset; Frans M Helmerhorst; Guido Tans; Jan Rosing
Effect of oral contraceptives on thrombin generation measured via calibrated automated thrombography.
Thrombosis and haemostasis 2007;98(6):1350-6.
2007: Kenneth Segers; Björn Dahlbäck; Paul E Bock; Guido Tans; Jan Rosing; Gerry A F Nicolaes
The role of thrombin exosites I and II in the activation of human coagulation factor V.
The Journal of biological chemistry 2007;282(47):33915-24.
2007: Imke C A Munnix; Marijke J E Kuijpers; Jocelyn M Auger; Christella M L G D Thomassen; Peter Panizzi; Marc A M J van Zandvoort; Jan Rosing; Paul E Bock; Steve P Watson; Johan W M Heemskerk
Segregation of platelet aggregatory and procoagulant microdomains in thrombus formation: regulation by transient integrin activation.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(11):2484-90.
2007: S N Tchaikovski; Bart J M van Vlijmen; Jan Rosing; Guido Tans
Development of a calibrated automated thrombography based thrombin generation test in mouse plasma.
Journal of thrombosis and haemostasis : JTH 2007;5(10):2079-86.
2007: Kenneth Segers; olivier Sperandio; Markus Sack; Rainer Fischer; Maria A Miteva; Jan Rosing; Gerry A F Nicolaes; Bruno Villoutreix
Design of protein membrane interaction inhibitors by virtual ligand screening, proof of concept with the C2 domain of factor V.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(31):12697-702.
2007: Heather K Kroh; Guido Tans; Gerry A F Nicolaes; Jan Rosing; Paul E Bock
Expression of allosteric linkage between the sodium ion binding site and exosite I of thrombin during prothrombin activation.
The Journal of biological chemistry 2007;282(22):16095-104.
2007: Elisabetta Castoldi; Paolo Simioni; Daniela Tormene; M Christella L G D Thomassen; Luca Spiezia; Sabrina Gavasso; Jan Rosing
Differential effects of high prothrombin levels on thrombin generation depending on the cause of the hyperprothrombinemia.
Journal of thrombosis and haemostasis : JTH 2007;5(5):971-9.
2007: A Brandts; Astrid Van Hylckama Vlieg; Jan Rosing; T P Baglin; F R Rosendaal
The risk of venous thrombosis associated with a high endogenous thrombin potential in the absence and presence of activated protein C.
Journal of thrombosis and haemostasis : JTH 2007;5(2):416-8.
2007: Elisabetta Castoldi; Barbara Lunghi; Jan Rosing; francesco bernardi
Factor V Kuwait alias factor V R3: a rare polymorphism of uncertain functional significance.
Medical principles and practice : international journal of the Kuwait University, Health Science Centre 2007;16(3):244-5; author reply 246.
2007: Eelco W Meesters; Hjalmar Hansen; Henri M H Spronk; Karly Hamulyak; Jan Rosing; Ajda T Rowshani; Ineke J M ten Berge; Hugo ten Cate
The inflammation and coagulation cross-talk in patients with systemic lupus erythematosus.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2007;18(1):21-8.
2006: Gerry A F Nicolaes; Tilman M Hackeng; Kenneth Segers; Jan Rosing
A structural model of the SHBG domain of human variant protein S Heerlen.
Thrombosis and haemostasis 2006;96(4):538-40.
2006: Svetlana Tchaikovski; Guido Tans; Jan Rosing
Venous thrombosis and oral contraceptives: current status.
Women's health (London, England) 2006;2(5):761-72.
2006: Kenneth Segers; Jan Rosing; Gerry A F Nicolaes
Structural models of the snake venom factor V activators from Daboia russelli and Daboia lebetina.
Proteins 2006;64(4):968-84.
2006: Majoie Hemelaar; Jan Rosing; Peter Kenemans; M Christella L G D Thomassen; D D M Braat; Marius J van der Mooren
Less effect of intranasal than oral hormone therapy on factors associated with venous thrombosis risk in healthy postmenopausal women.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(7):1660-6.
2006: Tilman M Hackeng; Kristin M Seré; Guido Tans; Jan Rosing
Protein S stimulates inhibition of the tissue factor pathway by tissue factor pathway inhibitor.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3106-11.
2006: Jeroen M Brugge; Guido Tans; Jan Rosing; Elisabetta Castoldi
Protein S levels modulate the activated protein C resistance phenotype induced by elevated prothrombin levels.
Thrombosis and haemostasis 2006;95(2):236-42.
2006: Kristin M Seré; George M Willems; Jan Rosing; Tilman M Hackeng
Protein S multimers are generated in vitro and affect protein S structure-function analyses.
Seminars in hematology 2006;43(1 Suppl 1):S111-20.
2005: Jeroen M Brugge; Paolo Simioni; francesco bernardi; Daniela Tormene; Barbara Lunghi; Guido Tans; Antonio Pagnan; Jan Rosing; Elisabetta Castoldi
Expression of the normal factor V allele modulates the APC resistance phenotype in heterozygous carriers of the factor V Leiden mutation.
Journal of thrombosis and haemostasis : JTH 2005;3(12):2695-702.
2005: Paolo Simioni; Elisabetta Castoldi; Barbara Lunghi; Daniela Tormene; Jan Rosing; francesco bernardi
An underestimated combination of opposites resulting in enhanced thrombotic tendency.
Blood 2005;106(7):2363-5.
2005: Marieke C H de Visser; Astrid Van Hylckama Vlieg; Guido Tans; Jan Rosing; Anders Dahm; Per Morten Sandset; Frits R Rosendaal; Rogier M Bertina
Determinants of the APTT- and ETP-based APC sensitivity tests.
Journal of thrombosis and haemostasis : JTH 2005;3(7):1488-94.
2005: Rory R Koenen; M Christella; L G D Thomassen; Guido Tans; Jan Rosing; Tilman M Hackeng
Effect of oral contraceptives on the anticoagulant activity of protein S in plasma.
Thrombosis and haemostasis 2005;93(5):853-9.
2005: Monica Galli; George M Willems; Jan Rosing; Rita M Janssen; José W P Govers-Riemslag; Paul Comfurius; Tiziano Barbui; Robert F A Zwaal; Edouard M Bevers
Anti-prothrombin IgG from patients with anti-phospholipid antibodies inhibits the inactivation of factor Va by activated protein C.
British journal of haematology 2005;129(2):240-7.
2005: Jan Rosing
Mechanisms of OC related thrombosis.
Thrombosis research 2005;115 Suppl 1():81-3.
2005: H A A M Van Vliet; Marijke Frolich; M Christella; L G D Thomassen; C J M Doggen; Frits R Rosendaal; Jan Rosing; Frans M Helmerhorst
Association between sex hormone-binding globulin levels and activated protein C resistance in explaining the risk of thrombosis in users of oral contraceptives containing different progestogens.
Human reproduction (Oxford, England) 2005;20(2):563-8.
2004: Kristin M Seré; Jan Rosing; Tilman M Hackeng
Inhibition of thrombin generation by protein S at low procoagulant stimuli: implications for maintenance of the hemostatic balance.
Blood 2004;104(12):3624-30.
2004: H A A M Van Vliet; T A Winkel; I Noort; Jan Rosing; F R Rosendaal
Prothrombotic changes in users of combined oral contraceptives containing drospirenone and cyproterone acetate.
Journal of thrombosis and haemostasis : JTH 2004;2(11):2060-2.
2004: Erik J J Duschek; Simone J M Neele; M Christella L G D Thomassen; Jan Rosing; JAN COEN NETELENBOS
Effect of raloxifene on activated protein C (APC) resistance in postmenopausal women and on APC resistance and homocysteine levels in elderly men: two randomized placebo-controlled studies.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2004;15(8):649-55.
2004: Kristof Vanschoonbeek; Marion A H Feijge; Martine Paquay; Jan Rosing; Wim Saris; Cornelis Kluft; peter giesen; Moniek P M de Maat; Johan W M Heemskerk
Variable hypocoagulant effect of fish oil intake in humans: modulation of fibrinogen level and thrombin generation.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(9):1734-40.
2004: Gerry A F Nicolaes; Kristoffer W Sørensen; Ute Friedrich; Guido Tans; Jan Rosing; Ludovic Autin; Björn Dahlbäck; Bruno Villoutreix
Altered inactivation pathway of factor Va by activated protein C in the presence of heparin.
European journal of biochemistry / FEBS 2004;271(13):2724-36.
2004: Rory R Koenen; Lucio Gomes; Guido Tans; Jan Rosing; Tilman M Hackeng
The Ser460Pro mutation in recombinant protein S Heerlen does not affect its APC-cofactor and APC-independent anticoagulant activities.
Thrombosis and haemostasis 2004;91(6):1105-14.
2004: Elisabetta Castoldi; Jeroen M Brugge; Gerry A F Nicolaes; Domenico Girelli; Guido Tans; Jan Rosing
Impaired APC cofactor activity of factor V plays a major role in the APC resistance associated with the factor V Leiden (R506Q) and R2 (H1299R) mutations.
Blood 2004;103(11):4173-9.
2004: Kristoffer W Sørensen; Gerry A F Nicolaes; Bruno Villoutreix; Tomio Yamazaki; Guido Tans; Jan Rosing; Björn Dahlbäck
Functional properties of recombinant factor V mutated in a potential calcium-binding site.
Biochemistry 2004;43(19):5803-10.
2004: Elisabetta Castoldi; Jan Rosing
Factor V Leiden: a disorder of factor V anticoagulant function.
Current opinion in hematology 2004;11(3):176-81.
2004: Annemiek W Nap; Karly Hamulyak; René Van Oerle; Lizzy C M van Pampus; Marc E A Spaanderman; J G M C Damoiseaux; Jan Rosing; Louis L H Peeters
Performance of a novel test to quantify activated protein C resistance in women with a history of pre-eclampsia.
European journal of obstetrics, gynecology, and reproductive biology 2004;113(1):26-30.
2004: Marijn van der Neut Kolfschoten; Richard J Dirven; Hans L Vos; Guido Tans; Jan Rosing; Rogier M Bertina
Factor Va is inactivated by activated protein C in the absence of cleavage sites at Arg-306, Arg-506, and Arg-679.
The Journal of biological chemistry 2004;279(8):6567-75.
2004: Jeanet M Kemmeren; Ale Algra; Joost C M Meijers; Guido Tans; Bonno N Bouma; Joyce Curvers; Jan Rosing; Diederick Grobbee
Effect of second- and third-generation oral contraceptives on the protein C system in the absence or presence of the factor VLeiden mutation: a randomized trial.
Blood 2004;103(3):927-33.
2004: Maria A Miteva; Jeroen M Brugge; Jan Rosing; Gerry A F Nicolaes; Bruno Villoutreix
Theoretical and experimental study of the D2194G mutation in the C2 domain of coagulation factor V.
Biophysical journal 2004;86(1 Pt 1):488-98.
2003: A W F T Toorians; M Christella L G D Thomassen; Sonja Zweegman; Elke J P Magdeleyns; Guido Tans; Louis J G Gooren; Jan Rosing
Venous thrombosis and changes of hemostatic variables during cross-sex hormone treatment in transsexual people.
The Journal of clinical endocrinology and metabolism 2003;88(12):5723-9.
2003: Elisabetta Castoldi; José W P Govers-Riemslag; Mirko Pinotti; Debora Bindini; Guido Tans; Mauro Berrettini; Maria Gabriella Mazzucconi; francesco bernardi; Jan Rosing
Coinheritance of Factor V (FV) Leiden enhances thrombin formation and is associated with a mild bleeding phenotype in patients homozygous for the FVII 9726+5G>A (FVII Lazio) mutation.
Blood 2003;102(12):4014-20.
2003: M Christella L G D Thomassen; Elisabetta Castoldi; Guido Tans; Elke J P Magdeleyns; Christian Delaunoit; Louisette Debusscher; Kris J A J Van Assche; Jan Rosing
Endogenous factor V synthesis in megakaryocytes contributes negligibly to the platelet factor V pool.
Haematologica 2003;88(10):1150-6.
2003: Rory R Koenen; Guido Tans; René Van Oerle; Karly Hamulyák; Jan Rosing; Tilman M Hackeng
The APC-independent anticoagulant activity of protein S in plasma is decreased by elevated prothrombin levels due to the prothrombin G20210A mutation.
Blood 2003;102(5):1686-92.
2003: Guido Tans; Astrid Van Hylckama Vlieg; M Christella L G D Thomassen; Joyce Curvers; Rogier M Bertina; Jan Rosing; Frits R Rosendaal
Activated protein C resistance determined with a thrombin generation-based test predicts for venous thrombosis in men and women.
British journal of haematology 2003;122(3):465-70.
2003: Marinka S Post; M Christella; L G D Thomassen; Marius J van der Mooren; W Marchien van Baal; Jan Rosing; Peter Kenemans; Coen D A Stehouwer
Effect of oral and transdermal estrogen replacement therapy on hemostatic variables associated with venous thrombosis: a randomized, placebo-controlled study in postmenopausal women.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(6):1116-21.
2003: Guido Tans; Bonno N Bouma; Harry R Büller; Jan Rosing
Changes of hemostatic variables during oral contraceptive use.
Seminars in vascular medicine 2003;3(1):61-8.
2003: Marten Nijziel; René Van Oerle; M Christella; L G D Thomassen; Elisabeth C M van Pampus; Karly Hamulyák; Guido Tans; Jan Rosing
Acquired resistance to activated protein C in breast cancer patients.
British journal of haematology 2003;120(1):117-22.
2002: Marinka S Post; Jan Rosing; Marius J van der Mooren; Sonja Zweegman; W Marchien van Baal; Peter Kenemans; Coen D A Stehouwer
Increased resistance to activated protein C after short-term oral hormone replacement therapy in healthy post-menopausal women.
British journal of haematology 2002;119(4):1017-23.
2002: José W P Govers-Riemslag; Elisabetta Castoldi; Gerry A F Nicolaes; Guido Tans; Jan Rosing
Reduced factor V concentration and altered FV1/FV2 ratio do not fully explain R2-associated APC-resistance.
Thrombosis and haemostasis 2002;88(3):444-9.
2002: Joyce Curvers; M Christella L G D Thomassen; Janet Rimmer; Karly Hamulyak; Jan van der Meer; Guido Tans; F Eric Preston; Jan Rosing
Effects of hereditary and acquired risk factors of venous thrombosis on a thrombin generation-based APC resistance test.
Thrombosis and haemostasis 2002;88(1):5-11.
2002: Marijn van der Neut Kolfschoten; Richard J Dirven; Guido Tans; Jan Rosing; Hans L Vos; Rogier M Bertina
The activated protein C (APC)-resistant phenotype of APC cleavage site mutants of recombinant factor V in a reconstituted plasma model.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2002;13(3):207-15.
2002: Joyce Curvers; M Christella; L G D Thomassen; Hans de Ronde; Rogier M Bertina; Frits R Rosendaal; Guido Tans; Jan Rosing
Effects of (pre-)analytical variables on activated protein C resistance determined via a thrombin generation-based assay.
Thrombosis and haemostasis 2002;87(3):483-92.
2001: Joyce Curvers; Annemiek W Nap; M Christella L G D Thomassen; S J Nienhuis; Karly Hamulyák; Johannes Evers; Guido Tans; Jan Rosing
Effect of in vitro fertilization treatment and subsequent pregnancy on the protein C pathway.
British journal of haematology 2001;115(2):400-7.
2001: Kristin M Seré; Marie P Janssen; George M Willems; Guido Tans; Jan Rosing; Tilman M Hackeng
Purified protein S contains multimeric forms with increased APC-independent anticoagulant activity.
Biochemistry 2001;40(30):8852-60.
2001: Jan P Vandenbroucke; Jan Rosing; Kitty W M Bloemenkamp; Saskia Middeldorp; Frans M Helmerhorst; Bonno N Bouma; Frits R Rosendaal
Oral contraceptives and the risk of venous thrombosis.
The New England journal of medicine 2001;344(20):1527-35.
2001: Jan Rosing; José W P Govers-Riemslag; L Yukelson; Guido Tans
Factor V activation and inactivation by venom proteases.
Haemostasis 2001;31(3-6):241-6.
2001: Guido Tans; Jan Rosing
Snake venom activators of factor X: an overview.
Haemostasis 2001;31(3-6):225-33.
2001: Joyce Curvers; S J Nienhuis; Annemiek W Nap; Karly Hamulyák; Johannes Evers; Jan Rosing
Activated protein C resistance during in vitro fertilization treatment.
European journal of obstetrics, gynecology, and reproductive biology 2001;95(2):222-4.
2001: Jan Rosing; Joyce Curvers; Guido Tans
Oral contraceptives, thrombosis and haemostasis.
European journal of obstetrics, gynecology, and reproductive biology 2001;95(2):193-7.
2001: Tilman M Hackeng; Jan Rosing; Henri M H Spronk; Cees Vermeer
Total chemical synthesis of human matrix Gla protein.
Protein science : a publication of the Protein Society 2001;10(4):864-70.
2001: L Hoekema; Elisabetta Castoldi; Guido Tans; Domenico Girelli; Donato Gemmati; francesco bernardi; Jan Rosing
Functional properties of factor V and factor Va encoded by the R2-gene.
Thrombosis and haemostasis 2001;85(1):75-81.
2000: L Hoekema; Jan Rosing; Guido Tans
An assay to quantify the two plasma isoforms of factor V.
Thrombosis and haemostasis 2000;84(6):1066-71.
2000: Guido Tans; Joyce Curvers; S Middeldorp; M Christella L G D Thomassen; Joost C M Meijers; Martin H Prins; Bonno N Bouma; Harry R Büller; Jan Rosing
A randomized cross-over study on the effects of levonorgestrel- and desogestrel-containing oral contraceptives on the anticoagulant pathways.
Thrombosis and haemostasis 2000;84(1):15-21.
2000: Joost C M Meijers; Saskia Middeldorp; Winnie L Tekelenburg; Abraham E van den Ende; Guido Tans; Martin H Prins; Jan Rosing; Harry R Büller; Bonno N Bouma
Increased fibrinolytic activity during use of oral contraceptives is counteracted by an enhanced factor XI-independent down regulation of fibrinolysis: a randomized cross-over study of two low-dose oral contraceptives.
Thrombosis and haemostasis 2000;84(1):9-14.
2000: Saskia Middeldorp; Joost C M Meijers; Abraham E van den Ende; A van Enk; Bonno N Bouma; Guido Tans; Jan Rosing; Martin H Prins; Harry R Büller
Effects on coagulation of levonorgestrel- and desogestrel-containing low dose oral contraceptives: a cross-over study.
Thrombosis and haemostasis 2000;84(1):4-8.
2000: Elisabetta Castoldi; Jan Rosing; Domenico Girelli; L Hoekema; Barbara Lunghi; Federico Mingozzi; Paolo Ferraresi; Simonetta Friso; Roberto Corrocher; Guido Tans; francesco bernardi
Mutations in the R2 FV gene affect the ratio between the two FV isoforms in plasma.
Thrombosis and haemostasis 2000;83(3):362-5.
1999: Jan Rosing; S Middeldorp; Joyce Curvers; M Christella; L G D Thomassen; Gerry A F Nicolaes; Joost C M Meijers; Bonno N Bouma; Harry R Büller; Martin H Prins; Guido Tans
Low-dose oral contraceptives and acquired resistance to activated protein C: a randomised cross-over study.
Lancet 1999;354(9195):2036-40.
1999: Jan Rosing; Guido Tans
Effects of oral contraceptives on hemostasis and thrombosis.
American journal of obstetrics and gynecology 1999;180(6 Pt 2):S375-82.
1999: Joyce Curvers; M Christella L G D Thomassen; Gerry A F Nicolaes; René Van Oerle; Karly Hamulyak; Coenraad Hemker; Guido Tans; Jan Rosing
Acquired APC resistance and oral contraceptives: differences between two functional tests.
British journal of haematology 1999;105(1):88-94.
1998: José W P Govers-Riemslag; Lise Lyck; RJ Petrovan; Jan Rosing; Guido Tans
A kinetic assay to determine prothrombin binding to membranes.
Thrombosis research 1998;92(5):239-47.
1998: RJ Petrovan; José W P Govers-Riemslag; G Nowak; Coenraad Hemker; Guido Tans; Jan Rosing
Autocatalytic peptide bond cleavages in prothrombin and meizothrombin.
Biochemistry 1998;37(5):1185-91.
1998: Jan Rosing; Coenraad Hemker; Guido Tans
Molecular biology and pathophysiology of APC resistance: current insights and clinical implications.
Seminars in thrombosis and hemostasis 1998;24(4):329-35.
1997: RJ Petrovan; José W P Govers-Riemslag; G Nowak; Coenraad Hemker; Jan Rosing; Guido Tans
Purification and characterization of multisquamase, the prothrombin activator present in Echis multisquamatus venom.
Thrombosis research 1997;88(3):309-16.
1997: Johan W M Heemskerk; Marion A H Feijge; L Henneman; Jan Rosing; Coenraad Hemker
The Ca2+-mobilizing potency of alpha-thrombin and thrombin-receptor-activating peptide on human platelets -- concentration and time effects of thrombin-induced Ca2+ signaling.
European journal of biochemistry / FEBS 1997;249(2):547-55.
1997: Jan Rosing; Guido Tans
Factor V.
The international journal of biochemistry & cell biology 1997;29(10):1123-6.
1997: Guido Tans; Gerry A F Nicolaes; Jan Rosing
Regulation of thrombin formation by activated protein C: effect of the factor V Leiden mutation.
Seminars in hematology 1997;34(3):244-55.
1997: Jan Rosing; Guido Tans
Coagulation factor V: an old star shines again.
Thrombosis and haemostasis 1997;78(1):427-33.
1997: René Van Oerle; L van Pampus; Guido Tans; Jan Rosing; Karly Hamulyák
The clinical application of a new specific functional assay to detect the factor V(Leiden) mutation associated with activated protein C resistance.
American journal of clinical pathology 1997;107(5):521-6.
1997: Jan Rosing; Guido Tans; Gerry A F Nicolaes; M Christella L G D Thomassen; René Van Oerle; P M van der Ploeg; P Heijnen; Karly Hamulyak; Coenraad Hemker
Oral contraceptives and venous thrombosis: different sensitivities to activated protein C in women using second- and third-generation oral contraceptives.
British journal of haematology 1997;97(1):233-8.
1997: L Hoekema; Gerry A F Nicolaes; Coenraad Hemker; Guido Tans; Jan Rosing
Human factor Va1 and factor Va2: properties in the procoagulant and anticoagulant pathways.
Biochemistry 1997;36(11):3331-5.
1997: Gerry A F Nicolaes; M Christella L G D Thomassen; Guido Tans; Jan Rosing; Coenraad Hemker
Effect of activated protein C on thrombin generation and on the thrombin potential in plasma of normal and APC-resistant individuals.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1997;8(1):28-38.
1996: T M Hackeng; Guido Tans; S J Koppelman; Philip G de Groot; Jan Rosing; Bonno N Bouma
Protein C activation on endothelial cells by prothrombin activation products generated in situ: meizothrombin is a better protein C activator than alpha-thrombin.
The Biochemical journal 1996;319 ( Pt 2)():399-405.
1996: Gerry A F Nicolaes; M Christella L G D Thomassen; René Van Oerle; Karly Hamulyak; Coenraad Hemker; Guido Tans; Jan Rosing
A prothrombinase-based assay for detection of resistance to activated protein C.
Thrombosis and haemostasis 1996;76(3):404-10.
1995: Jan Rosing; L Hoekema; Gerry A F Nicolaes; M Christella L G D Thomassen; Coenraad Hemker; K Varadi; H P Schwarz; Guido Tans
Effects of protein S and factor Xa on peptide bond cleavages during inactivation of factor Va and factor VaR506Q by activated protein C.
The Journal of biological chemistry 1995;270(46):27852-8.
1995: Gerry A F Nicolaes; Guido Tans; M Christella L G D Thomassen; Coenraad Hemker; I Pabinger; K Varadi; H P Schwarz; Jan Rosing
Peptide bond cleavages and loss of functional activity during inactivation of factor Va and factor VaR506Q by activated protein C.
The Journal of biological chemistry 1995;270(36):21158-66.
1994: H M Bakker; Guido Tans; M Christella L G D Thomassen; L Y Yukelson; R Ebberink; Coenraad Hemker; Jan Rosing
Functional properties of human factor Va lacking the Asp683-Arg709 domain of the heavy chain.
The Journal of biological chemistry 1994;269(32):20662-7.
1994: Guido Tans; Gerry A F Nicolaes; M Christella L G D Thomassen; Coenraad Hemker; Anton-Jan van Zonneveld; Hans Pannekoek; Jan Rosing
Activation of human factor V by meizothrombin.
The Journal of biological chemistry 1994;269(23):15969-72.
1994: Mary J Heeb; Jan Rosing; H M Bakker; J A Fernandez; Guido Tans; J H Griffin
Protein S binds to and inhibits factor Xa.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(7):2728-32.
1994: José W P Govers-Riemslag; M P Janssen; Robert F A Zwaal; Jan Rosing
Prothrombin activation on dioleoylphosphatidylcholine membranes.
European journal of biochemistry / FEBS 1994;220(1):131-8.
1993: Jan Rosing; H M Bakker; M Christella L G D Thomassen; Coenraad Hemker; Guido Tans
Characterization of two forms of human factor Va with different cofactor activities.
The Journal of biological chemistry 1993;268(28):21130-6.
1993: H M Bakker; Guido Tans; L Y Yukelson; T W Janssen-Claessen; R M Bertina; Coenraad Hemker; Jan Rosing
Protein C activation by an activator purified from the venom of Agkistrodon halys halys.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 1993;4(4):605-14.
1993: Mary J Heeb; R M Mesters; Guido Tans; Jan Rosing; John H Griffin
Binding of protein S to factor Va associated with inhibition of prothrombinase that is independent of activated protein C.
The Journal of biological chemistry 1993;268(4):2872-7.
1992: Jan Rosing; Guido Tans
Structural and functional properties of snake venom prothrombin activators.
Toxicon : official journal of the International Society on Toxinology 1992;30(12):1515-27.
1992: José W P Govers-Riemslag; M P Janssen; Robert F A Zwaal; Jan Rosing
Effect of membrane fluidity and fatty acid composition on the prothrombin-converting activity of phospholipid vesicles.
Biochemistry 1992;31(41):10000-8.
1992: I Gerads; Guido Tans; Robert F A Zwaal; Jan Rosing
Activation of bovine factor V by an activator purified from the venom of Naja naja oxiana.
Toxicon : official journal of the International Society on Toxinology 1992;30(9):1065-79.
1992: H M Bakker; Guido Tans; T Janssen-Claessen; M Christella L G D Thomassen; Coenraad Hemker; J H Griffin; Jan Rosing
The effect of phospholipids, calcium ions and protein S on rate constants of human factor Va inactivation by activated human protein C.
European journal of biochemistry / FEBS 1992;208(1):171-8.
1991: Guido Tans; T Janssen-Claessen; Coenraad Hemker; Robert F A Zwaal; Jan Rosing
Meizothrombin formation during factor Xa-catalyzed prothrombin activation. Formation in a purified system and in plasma.
The Journal of biological chemistry 1991;266(32):21864-73.
1991: Guido Tans; Jan Rosing; M Christella L G D Thomassen; Mary J Heeb; Robert F A Zwaal; J H Griffin
Comparison of anticoagulant and procoagulant activities of stimulated platelets and platelet-derived microparticles.
Blood 1991;77(12):2641-8.
1991: Jan Rosing; Guido Tans
Inventory of exogenous prothrombin activators. For the Subcommittee on Nomenclature of Exogenous Hemostatic Factors of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis.
Thrombosis and haemostasis 1991;65(5):627-30.
1991: L Y Yukelson; Guido Tans; M Christella L G D Thomassen; Coenraad Hemker; Jan Rosing
Procoagulant activities in venoms from central Asian snakes.
Toxicon : official journal of the International Society on Toxinology 1991;29(4-5):491-502.
1990: I Gerads; José W P Govers-Riemslag; Guido Tans; Robert F A Zwaal; Jan Rosing
Prothrombin activation on membranes with anionic lipids containing phosphate, sulfate, and/or carboxyl groups.
Biochemistry 1990;29(34):7967-74.
1989: Guido Tans; T Janssen-Claessen; Jan Rosing
Amidolytic detection of prothrombin activation products after SDS-gel electrophoresis.
Thrombosis and haemostasis 1989;61(3):386-91.
1988: Jan Rosing; Guido Tans
Meizothrombin, a major product of factor Xa-catalyzed prothrombin activation.
Thrombosis and haemostasis 1988;60(3):355-60.
1988: Jan Rosing; Guido Tans; Han Speijer; Robert F A Zwaal
Calcium-independent activation of prothrombin on membranes with positively charged lipids.
Biochemistry 1988;27(25):9048-55.
1988: Jan Rosing; Han Speijer; Robert F A Zwaal
Prothrombin activation on phospholipid membranes with positive electrostatic potential.
Biochemistry 1988;27(1):8-11.
1987: José W P Govers-Riemslag; M J Knapen; Guido Tans; Robert F A Zwaal; Jan Rosing
Structural and functional characterization of a prothrombin activator from the venom of Bothrops neuwiedi.
Biochimica et biophysica acta 1987;916(3):388-401.
1987: Han Speijer; José W P Govers-Riemslag; Robert F A Zwaal; Jan Rosing
Platelet procoagulant properties studied with snake venom prothrombin activators.
Thrombosis and haemostasis 1987;57(3):349-55.
1987: Guido Tans; T Janssen-Claessen; Jan Rosing; J H Griffin
Studies on the effect of serine protease inhibitors on activated contact factors. Application in amidolytic assays for factor XIIa, plasma kallikrein and factor XIa.
European journal of biochemistry / FEBS 1987;164(3):637-42.
1986: Han Speijer; José W P Govers-Riemslag; Robert F A Zwaal; Jan Rosing
Prothrombin activation by an activator from the venom of Oxyuranus scutellatus (Taipan snake).
The Journal of biological chemistry 1986;261(28):13258-67.
1986: J L van Rijn; R F Zwaal; Coenraad Hemker; Jan Rosing
Role of accessory components in the activation of vitamin K-dependent coagulation factors.
Haemostasis 1986;16(3-4):216-26.
1985: Guido Tans; José W P Govers-Riemslag; J L van Rijn; Jan Rosing
Purification and properties of a prothrombin activator from the venom of Notechis scutatus scutatus.
The Journal of biological chemistry 1985;260(16):9366-72.
1985: G van Dieijen; J L van Rijn; José W P Govers-Riemslag; Coenraad Hemker; Jan Rosing
Assembly of the intrinsic factor X activating complex--interactions between factor IXa, factor VIIIa and phospholipid.
Thrombosis and haemostasis 1985;53(3):396-400.
1985: Jan Rosing; E M Bevers; P Comfurius; Coenraad Hemker; G van Dieijen; H J Weiss; Robert F A Zwaal
Impaired factor X and prothrombin activation associated with decreased phospholipid exposure in platelets from a patient with a bleeding disorder.
Blood 1985;65(6):1557-61.
1985: José W P Govers-Riemslag; Han Speijer; Robert F A Zwaal; Jan Rosing
The effects of bovine prothrombin fragment 1 and fragment 1.2 on prothrombin activation.
Thrombosis research 1985;38(4):375-88.
1985: Jan Rosing; J L van Rijn; E M Bevers; G van Dieijen; P Comfurius; Robert F A Zwaal
The role of activated human platelets in prothrombin and factor X activation.
Blood 1985;65(2):319-32.
1984: J L van Rijn; José W P Govers-Riemslag; Robert F A Zwaal; Jan Rosing
Kinetic studies of prothrombin activation: effect of factor Va and phospholipids on the formation of the enzyme-substrate complex.
Biochemistry 1984;23(20):4557-64.
1983: J van Rijn; Jan Rosing; G van Dieijen
Activity of human blood platelets in prothrombin and in factor X activation induced by ionophore A23187.
European journal of biochemistry / FEBS 1983;133(1):1-10.
1983: Coenraad Hemker; J L van Rijn; Jan Rosing; G van Dieijen; E M Bevers; Robert F A Zwaal
Platelet membrane involvement in blood coagulation.
Blood cells 1983;9(2):303-17.
1982: Guido Tans; T Janssen-Claessen; G van Dieijen; Coenraad Hemker; Jan Rosing
Activation of factor IX by factor XIa--a spectrophotometric assay for factor IX in human plasma.
Thrombosis and haemostasis 1982;48(2):127-32.
1982: T Lindhout; José W P Govers-Riemslag; P van de Waart; Coenraad Hemker; Jan Rosing
Factor Va-factor Xa interaction. Effects of phospholipid vesicles of varying composition.
Biochemistry 1982;21(22):5494-502.
1982: M P van Dieijen-Visser; J van Wersch; P J Brombacher; Jan Rosing; Coenraad Hemker; G van Dieijen
Use of chromogenic peptide substrates in the determination of clotting factors II, VII, IX and X in normal plasma and in plasma of patients treated with oral anticoagulants.
Haemostasis 1982;12(3):241-55.
1981: G van Dieijen; Guido Tans; J van Rijn; Robert F A Zwaal; Jan Rosing
Simple and rapid method to determine the binding of blood clotting factor X to phospholipid vesicles.
Biochemistry 1981;20(25):7096-101.
1981: G van Dieijen; Guido Tans; Jan Rosing; Coenraad Hemker
The role of phospholipid and factor VIIIa in the activation of bovine factor X.
The Journal of biological chemistry 1981;256(7):3433-42.
1980: Jan Rosing; Guido Tans; José W P Govers-Riemslag; Robert F A Zwaal; Coenraad Hemker
The role of phospholipids and factor Va in the prothrombinase complex.
The Journal of biological chemistry 1980;255(1):274-83.