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Christopher Ross

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Sandra M Holley; J David Jentsch; Mikhail V Pletnikov; Christopher A Ross; Elizabeth A Wang; Carlos Cepeda; Michael S Levine
Frontal cortical synaptic communication is abnormal in Disc1 genetic mouse models of schizophrenia.
Jing Jin; Qi Peng; Christopher A Ross; Gay Rudow; Juan C Troncoso; Jennifer Albertz; Zhihong Guo; Wenzhen Duan
Neuroprotective effects of PPAR-γ agonist rosiglitazone in N171-82Q mouse model of Huntington's disease.
Haiming Chen; K Sue O'Shea; Christopher A Ross; Nulang Wang; Xin Zhao; Melvin G McInnis
Gene expression alterations in bipolar disorder postmortem brains.

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2013: Sandra M Holley; J David Jentsch; Mikhail V Pletnikov; Christopher A Ross; Elizabeth A Wang; Carlos Cepeda; Michael S Levine
Frontal cortical synaptic communication is abnormal in Disc1 genetic mouse models of schizophrenia.
Schizophrenia research 2013;146(1-3):264-72.
2013: Jing Jin; Qi Peng; Christopher A Ross; Gay Rudow; Juan C Troncoso; Jennifer Albertz; Zhihong Guo; Wenzhen Duan
Neuroprotective effects of PPAR-γ agonist rosiglitazone in N171-82Q mouse model of Huntington's disease.
Journal of neurochemistry 2013;125(3):410-9.
2013: Haiming Chen; K Sue O'Shea; Christopher A Ross; Nulang Wang; Xin Zhao; Melvin G McInnis
Gene expression alterations in bipolar disorder postmortem brains.
Bipolar disorders 2013;15(2):177-87.
2012: Leslie J Cloud; Jody Corey-Bloom; Stewart A Factor; Sandra L Helmers; Donald S Higgins; Randi Jones; Russell L Margolis; Charles A Nichter; Peter K Panegyres; Jagan A Pillai; Adam Rosenblatt; Christopher A Ross; Thomas Bird; Hannah M Tully; Claudia M Testa
Seizures in juvenile Huntington's disease: frequency and characterization in a multicenter cohort.
Movement disorders : official journal of the Movement Disorder Society 2012;27(14):1797-800.
2012: Eliana Marisa Ramos; Herminia D Rosas; Christopher A Ross; Marie-Helene Saint-Hilaire; Jorge Sequeiros; Ferdinando Squitieri; Oksana Suchowersky; Ronald J Trent; Andrea Zanko; Karen Marder; Russell L Margolis; Elizabeth McCusker; Patrick J Morrison; Richard H Myers; Jayalakshmi S Mysore; Martha Nance; Andrea Novelletto; Isabel Alonso; Tetsuo Ashizawa; Carmen Ayuso; Stefano Di Donato; Alba Di Pardo; Samuel Frank; Marina Frontali; Tammy Gillis; Estrella Gomez-Tortosa; James F Gusella; Madaline B Harrison; Michael R Hayden; Steven M Hersch; Randi Jones; Jeanne C Latourelle; Ji-Hyun Lee; Jong-Min Lee; Diane Lucente; Marcy E Macdonald
Population stratification may bias analysis of PGC-1α as a modifier of age at Huntington disease motor onset.
Human genetics 2012;131(12):1833-40.
2012: Zhihong Guo; Russell L Margolis; Brent A Orr; Olga Pletnikova; Adam Rosenblatt; Christopher A Ross; Gay Rudow; Kari-Elise Codispoti; Barbara J Crain; WENZHEN DUAN; Juan C Troncoso
Striatal neuronal loss correlates with clinical motor impairment in Huntington's disease.
Movement disorders : official journal of the Movement Disorder Society 2012;27(11):1379-86.
2012: Dejun Yang; Jianqun Yan; nicolas arbez; Tianxia Li; Zhaohui Liu; Timothy H Moran; Christopher A Ross; Wanli Smith
LRRK2 kinase activity mediates toxic interactions between genetic mutation and oxidative stress in a Drosophila model: suppression by curcumin.
Neurobiology of disease 2012;47(3):385-92.
2012: X Li; Z Liu; Timothy H Moran; Christopher A Ross; Susan Aja; N T Bello; Sheng Bi; Ellen E Ladenheim; Kellie L K Tamashiro; X Wang; Wanli Smith
A novel obesity model: synphilin-1-induced hyperphagia and obesity in mice.
International journal of obesity (2005) 2012;36(9):1215-21.
2012: Ji-Hyun Lee; Jong-Min Lee; Diane Lucente; Marcy E MacDonald; Karen Marder; Russell L Margolis; Elizabeth McCusker; Patrick J Morrison; Richard H Myers; Jayalakshmi S Mysore; Martha Nance; Andrea Novelletto; Eliana Marisa Ramos; Herminia D Rosas; Christopher A Ross; Marie-Helene Saint-Hilaire; Jorge Sequeiros; Ira Shoulson; Ferdinando Squitieri; Oksana Suchowersky; Ronald J Trent; Andrea Zanko; Ruth K Abramson; Tetsuo Ashizawa; Carmen Ayuso; Samuel Frank; Marina Frontali; Cinzia Gellera; Tammy Gillis; Estrella Gomez-Tortosa; Tiffany Hadzi; Madaline B Harrison; Michael R Hayden; Audrey E Hendricks; Steven M Hersch; Randi Jones; Shotaro Kishikawa; G Bernhard Landwehrmeyer; James F Gusella
TAA repeat variation in the GRIK2 gene does not influence age at onset in Huntington's disease.
Biochemical and biophysical research communications 2012;424(3):404-8.
2012: Paul G Unschuld; Peter C M van Zijl; Adam Rosenblatt; Christopher A Ross; Megan Shanahan; Arnold Bakker; Susan S Bassett; Suresh E Joel; Russell L Margolis; Julie McEntee; Susumu Mori; KENICHI OISHI; James J Pekar; Sarah A J Reading; GRAHAM REDGRAVE
Depressive symptoms in prodromal Huntington's Disease correlate with Stroop-interference related functional connectivity in the ventromedial prefrontal cortex.
Psychiatry research 2012;203(2-3):166-74.
2012: Jinrong Fu; Serena A Hageman; Katelyn Hotaling; Mali Jiang; Jing Jin; Qi Peng; Christopher A Ross; Lan Xiang; nicolas arbez; Robert H Cichewicz; Trevor K Ellis; WENZHEN DUAN
trans-(-)-ε-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington Disease.
The Journal of biological chemistry 2012;287(29):24460-72.
2012: Paul G Unschuld; Peter C M van Zijl; Xin Wang; Megan Shanahan; Peter B Barker; Susan S Bassett; Jason Brandt; Aaron Carass; RIchard Edden; Xinyang Liu; Russell L Margolis; KENICHI OISHI; GRAHAM REDGRAVE; Christopher A Ross
Brain metabolite alterations and cognitive dysfunction in early Huntington's disease.
Movement disorders : official journal of the Movement Disorder Society 2012;27(7):895-902.
2012: TAMARA RATOVITSKI; nicolas arbez; Tatiana Boronina; Ekaterine Chighladze; Robert N Cole; Shelley Herbrich; Christopher A Ross
Huntingtin protein interactions altered by polyglutamine expansion as determined by quantitative proteomic analysis.
Cell cycle (Georgetown, Tex.) 2012;11(10):2006-21.
2012: Leslie G Nucifora; TAMARA RATOVITSKI; Christopher A Ross; Guocheng Yang; Shanshan Zhu; nicolas arbez; Kathleen A Burke; Michael Delannoy; Xia Feng; Steven Finkbeiner; Justin Legleiter; Jason Miller; Paul J Muchowski; Michelle A Poirier
Identification of novel potentially toxic oligomers formed in vitro from mammalian-derived expanded huntingtin exon-1 protein.
The Journal of biological chemistry 2012;287(19):16017-28.
2012: Manisha Aggarwal; WENZHEN DUAN; Zhipeng Hou; Michael I Miller; Susumu Mori; Qi Peng; Neal Rakesh; Christopher A Ross; Jiangyang Zhang
Spatiotemporal mapping of brain atrophy in mouse models of Huntington's disease using longitudinal in vivo magnetic resonance imaging.
NeuroImage 2012;60(4):2086-95.
2012: Elizabeth H Aylward; Dawei Liu; Jeffrey D Long; James A Mills; Peggy C Nopoulos; Jane S Paulsen; Ronald Pierson; Christopher A Ross
Striatal volume contributes to the prediction of onset of Huntington disease in incident cases.
Biological psychiatry 2012;71(9):822-8.
2012: Paul G Unschuld; Peter C M van Zijl; David J Schretlen; Megan Shanahan; Susan S Bassett; Kevin M Biglan; Suresh E Joel; Xinyang Liu; Russell L Margolis; James J Pekar; GRAHAM REDGRAVE; Christopher A Ross
Impaired cortico-striatal functional connectivity in prodromal Huntington's Disease.
Neuroscience letters 2012;514(2):204-9.
2012: Jong-Min Lee; Diane Lucente; Marcy E MacDonald; Karen Marder; Russell L Margolis; Elizabeth McCusker; Patrick J Morrison; Richard H Myers; Jayalakshmi Srinidhi Mysore; Martha Nance; Andrea Novelletto; Eliana Marisa Ramos; Herminia D Rosas; Christopher A Ross; Marie-Helene Saint-Hilaire; Jorge Sequeiros; Ferdinando Squitieri; Oksana Suchowersky; Ronald J Trent; Andrea Zanko; Ruth K Abramson; Tetsuo Ashizawa; Carmen Ayuso; Stefano Di Donato; Samuel Frank; Marina Frontali; Tammy Gillis; Estrella Gomez-Tortosa; Annamaria Griguoli; Madaline B Harrison; Michael R Hayden; Steven M Hersch; Randi Jones; James F Gusella
Common SNP-based haplotype analysis of the 4p16.3 Huntington disease gene region.
American journal of human genetics 2012;90(3):434-44.
2012: J-M Lee; D Lucente; Marcy E MacDonald; K Marder; Russell L Margolis; E McCusker; P Morrison; R H Myers; J S Mysore; M Nance; A Novelletto; S Orobello; Jane S Paulsen; E M Ramos; H D Rosas; Christopher A Ross; M H Saint-Hilaire; J Sequeiros; F Squitieri; O Suchowersky; R J A Trent; S C Warby; A Zanko; R K Abramson; T Ashizawa; C Ayuso; S Di Donato; S Frank; M Frontali; T Gillis; E Gomez-Tortosa; J F Gusella; M B Harrison; Michael R Hayden; Steven M Hersch; R Jones; G B Landwehrmeyer; J-H Lee
CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion.
Neurology 2012;78(10):690-5.
2012: Ana I Seixas; Isabel Silveira; Hiroshi Takeshima; Nancy Sachs; Susan E Holmes; Russell L Margolis; Amira Pavlovich; Jennifer L Pruitt; Christopher A Ross; Dobrila D Rudnicki
Loss of junctophilin-3 contributes to Huntington disease-like 2 pathogenesis.
Annals of neurology 2012;71(2):245-57.
2012: Adam Rosenblatt; Brahma V Kumar; Russell L Margolis; Alisa Mo; Claire S Welsh; Christopher A Ross
Age, CAG repeat length, and clinical progression in Huntington's disease.
Movement disorders : official journal of the Movement Disorder Society 2012;27(2):272-6.
2012: Elaine Waldron-Roby; XiaoFang Wang; Erin Watkin; Deborah Swing; Lino Tessarollo; nicolas arbez; WENZHEN DUAN; Graham Kyrenia Rona; Michael R Hayden; Zhipeng Hou; Mali Jiang; Susumu Mori; Mikhail V Pletnikov; TAMARA RATOVITSKI; Christopher A Ross
Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(1):183-93.
2012: Tarja A Juopperi; Woon Ryoung Kim; Russell L Margolis; Guo-Li Ming; Christopher A Ross; Cheng-Hsuan Chiang; Huimei Yu; Hongjun Song
Astrocytes generated from patient induced pluripotent stem cells recapitulate features of Huntington's disease patient cells.
Molecular brain 2012;5():17.
2012: Mali Jiang; Huan Cai; Ruth Luthi-Carter; Kellie L K Tamashiro; Jiangyang Zhang; Lin Du; Bronwen Martin; Susan Aja; Susumu Mori; Christopher A Ross; Timothy H Moran; Stuart Maudsley; Lan Xiang; David M Holtzman; Mark P Mattson; Jiawei Wang; Qi Peng; Tamara Seredenina; Katherine Sommers; Hyunkyung Jeong; Zhipeng Hou; X William Yang; nicolas arbez; Jennifer Qian; Tim West; Dimitri Krainc; Jinrong Fu; Robert H Cichewicz; Shanshan Zhu; WENZHEN DUAN
Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets.
Nature medicine 2012;18(1):153-8.
2011: Pavel Katsel; Mikhail V Pletnikov; Christopher A Ross; Weilun Tan; Bagrat Abazyan; Kenneth L Davis; Vahram Haroutunian
Expression of mutant human DISC1 in mice supports abnormalities in differentiation of oligodendrocytes.
Schizophrenia research 2011;130(1-3):238-49.
2011: Adam Rosenblatt; Brahma V Kumar; Russell L Margolis; Claire S Welsh; Christopher A Ross
Factors contributing to institutionalization in patients with Huntington's disease.
Movement disorders : official journal of the Movement Disorder Society 2011;26(9):1711-6.
2011: Yu Wang; Thomas T Egelhoff; Yixin Ren; Douglas Robinson; Christopher A Ross; Hiromi Sesaki; Paul A Steimle; Miho Iijima
Dictyostelium huntingtin controls chemotaxis and cytokinesis through the regulation of myosin II phosphorylation.
Molecular biology of the cell 2011;22(13):2270-81.
2011: Yong Cheng; Qi Peng; Zhipeng Hou; Manisha Aggarwal; Jiangyang Zhang; Susumu Mori; Christopher A Ross; WENZHEN DUAN
Structural MRI detects progressive regional brain atrophy and neuroprotective effects in N171-82Q Huntington's disease mouse model.
NeuroImage 2011;56(3):1027-34.
2011: Zhaohui Liu; Yihua Bruce Yu; Xueping Li; Christopher A Ross; Wanli Smith
Curcumin protects against A53T alpha-synuclein-induced toxicity in a PC12 inducible cell model for Parkinsonism.
Pharmacological research : the official journal of the Italian Pharmacological Society 2011;63(5):439-44.
2011: TAMARA RATOVITSKI; Ekaterine Chighladze; Elaine Waldron; RICKY HIRSCHHORN; Christopher A Ross
Cysteine proteases bleomycin hydrolase and cathepsin Z mediate N-terminal proteolysis and toxicity of mutant huntingtin.
The Journal of biological chemistry 2011;286(14):12578-89.
2011: C-H Chiang; Y Su; Z Wen; N Yoritomo; Christopher A Ross; Russell L Margolis; Hongjun Song; Guo-Li Ming
Integration-free induced pluripotent stem cells derived from schizophrenia patients with a DISC1 mutation.
Molecular psychiatry 2011;16(4):358-60.
2011: Elizabeth H Aylward; Peggy C Nopoulos; Christopher A Ross; Douglas R Langbehn; Ronald K Pierson; James A Mills; Hans J Johnson; Vincent A Magnotta; Andrew R Juhl; Jane S Paulsen
Longitudinal change in regional brain volumes in prodromal Huntington disease.
Journal of neurology, neurosurgery, and psychiatry 2011;82(4):405-10.
2011: Qi Charles Zhang; Tzu-lan Yeh; Alfonso Leyva; Leslie G Frank; Jason Miller; Yujin E Kim; Ralf Langen; Steven Finkbeiner; Mario Amzel; Christopher A Ross; Michelle A Poirier
A compact beta model of huntingtin toxicity.
The Journal of biological chemistry 2011;286(10):8188-96.
2011: Y Ayhan; B Abazyan; Jun Nomura; R Kim; Bruce Ladenheim; I N Krasnova; Akira Sawa; Russell L Margolis; Jean Lud Cadet; Susumu Mori; Michael W Vogel; Christopher A Ross; Jun Nomura
Differential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice: evidence for neurodevelopmental origin of major psychiatric disorders.
Molecular psychiatry 2011;16(3):293-306.
2011: Sarah A J Reading; GRAHAM REDGRAVE; Russell L Margolis; Julie McEntee; Michael I Miller; Susumu Mori; KENICHI OISHI; Megan Shanahan; Peter C M van Zijl; Nadine Yoritomo; Laurent Younes; Christopher A Ross
Diffuse abnormality of low to moderately organized white matter in schizophrenia.
Brain connectivity 2011;1(6):511-9.
2011: Elizabeth H Aylward; James Mills; Dawei Liu; Peggy Nopoulos; Christopher A Ross; Ronald Pierson; Jane S Paulsen
Association between Age and Striatal Volume Stratified by CAG Repeat Length in Prodromal Huntington Disease.
PLoS currents 2011;3():RRN1235.
2011: Christopher A Ross; Sarah J Tabrizi
Huntington's disease: from molecular pathogenesis to clinical treatment.
Lancet neurology 2011;10(1):83-98.
2011: Peggy C Nopoulos; Elizabeth H Aylward; Christopher A Ross; James A Mills; Douglas R Langbehn; Hans J Johnson; Vincent A Magnotta; Ronald K Pierson; Leigh J Beglinger; Martha A Nance; Roger A Barker; Jane S Paulsen
Smaller intracranial volume in prodromal Huntington's disease: evidence for abnormal neurodevelopment.
Brain : a journal of neurology 2011;134(Pt 1):137-42.
2010: Bagrat Abazyan; Jun Nomura; Geetha Kannan; Koko Ishizuka; Kellie L K Tamashiro; Frederick C Nucifora; Vladimir Pogorelov; Bruce Ladenheim; Chunxia Yang; Irina N Krasnova; Jean Lud Cadet; CARLOS PARDO-VILLAMIZAR; Susumu Mori; Atsushi Kamiya; Michael W Vogel; Akira Sawa; Christopher A Ross; Jun Nomura
Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology.
Biological psychiatry 2010;68(12):1172-81.
2010: Peg Nopoulos; Elizabeth H Aylward; Christopher A Ross; Hans J Johnson; Vincent A Magnotta; Andrew R Juhl; Ronald Pierson; James Mills; Douglas R Langbehn; Jane S Paulsen
Cerebral cortex structure in prodromal Huntington disease.
Neurobiology of disease 2010;40(3):544-54.
2010: R Sanz; D Navas; M Vazquez; M Hernández-Vélez; Christopher A Ross
Preparation and magnetic properties of cylindrical NiFe films and antidot arrays.
Journal of nanoscience and nanotechnology 2010;10(10):6775-8.
2010: WENZHEN DUAN; Christopher A Ross
Potential therapeutic targets for neurodegenerative diseases: lessons learned from calorie restriction.
Current drug targets 2010;11(10):1281-92.
2010: Mali Jiang; Yair Porat-Shliom; Zhong Pei; Yong Cheng; Lan Xiang; Katherine Sommers; Qing Li; Frank Gillardon; Bastian Hengerer; CYNTHIA BERLINICKE; Wanli Smith; Donald J Zack; Michelle A Poirier; Christopher A Ross; WENZHEN DUAN
Baicalein reduces E46K alpha-synuclein aggregation in vitro and protects cells against E46K alpha-synuclein toxicity in cell models of familiar Parkinsonism.
Journal of neurochemistry 2010;114(2):419-29.
2010: Wanli Smith; Zhaohui Liu; Yideng Liang; Naoki Masuda; Debbie A Swing; Nancy A Jenkins; Neal G Copeland; Juan C Troncoso; Mikhail V Pletnikov; Ted M Dawson; Lee J Martin; Timothy H Moran; Michael K Lee; David R Borchelt; Christopher A Ross
Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model.
Human molecular genetics 2010;19(11):2087-98.
2010: Jane S Paulsen; Peg Nopoulos; Elizabeth H Aylward; Christopher A Ross; Hans Johnson; Vincent A Magnotta; Andrew Juhl; Ronald Pierson; James Mills; Douglas R Langbehn; Martha Nance
Striatal and white matter predictors of estimated diagnosis for Huntington disease.
Brain research bulletin 2010;82(3-4):201-7.
2010: Jiangyang Zhang; Qi Peng; Q Li; Neda Jahanshad; Zhipeng Hou; Mali Jiang; Naoki Masuda; Douglas R Langbehn; Michael I Miller; Susumu Mori; Christopher A Ross; WENZHEN DUAN
Longitudinal characterization of brain atrophy of a Huntington's disease mouse model by automated morphological analyses of magnetic resonance images.
NeuroImage 2010;49(3):2340-51.
2010: X Li; Z Liu; Kellie L K Tamashiro; B Shi; Dobrila D Rudnicki; Christopher A Ross; Timothy H Moran; Wanli Smith
Synphilin-1 exhibits trophic and protective effects against Rotenone toxicity.
Neuroscience 2010;165(2):455-62.
2010: Kevin Duff; Jane S Paulsen; Leigh J Beglinger; Douglas R Langbehn; Chiachi Wang; Julie C Stout; Christopher A Ross; Elizabeth H Aylward; Noelle E Carlozzi; Sarah Queller
"Frontal" behaviors before the diagnosis of Huntington's disease and their relationship to markers of disease progression: evidence of early lack of awareness.
The Journal of neuropsychiatry and clinical neurosciences 2010;22(2):196-207.
2010: Russell L Margolis; Christopher A Ross
Neuronal signaling pathways: genetic insights into the pathophysiology of major mental illness.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2010;35(1):350-1.
2009: Yavuz Ayhan; Akira Sawa; Christopher A Ross; Mikhail V Pletnikov
Animal models of gene-environment interactions in schizophrenia.
Behavioural brain research 2009;204(2):274-81.
2009: Christopher A Ross; Ira Shoulson
Huntington disease: pathogenesis, biomarkers, and approaches to experimental therapeutics.
Parkinsonism & related disorders 2009;15 Suppl 3():S135-8.
2009: M M Rainka; H A Capote; Christopher A Ross; Fran M Gengo
Attenuation of risperidone-induced hyperprolactinemia with the addition of aripiprazole.
Journal of clinical pharmacy and therapeutics 2009;34(5):595-8.
2009: Kevin M Biglan; Christopher A Ross; Douglas R Langbehn; Elizabeth H Aylward; Julie C Stout; Sarah Queller; Noelle E Carlozzi; Kevin Duff; Leigh J Beglinger; Jane S Paulsen
Motor abnormalities in premanifest persons with Huntington's disease: the PREDICT-HD study.
Movement disorders : official journal of the Movement Disorder Society 2009;24(12):1763-72.
2009: Yideng Liang; Haibing Jiang; TAMARA RATOVITSKI; Chunfa Jie; Masayuki Nakamura; RICKY HIRSCHHORN; Xiaofang Wang; Wanli Smith; Tsonwin Hai; Michelle A Poirier; Christopher A Ross
ATF3 plays a protective role against toxicity by N-terminal fragment of mutant huntingtin in stable PC12 cell line.
Brain research 2009;1286():221-9.
2009: Christopher A Ross; Russell L Margolis
Schizophrenia: A point of disruption.
Nature 2009;458(7241):976-7.
2009: TAMARA RATOVITSKI; Marjan Gucek; Haibing Jiang; Ekaterine Chighladze; Elaine Waldron; James D'Ambola; Zhipeng Hou; Yideng Liang; Michelle A Poirier; RICKY HIRSCHHORN; Graham Kyrenia Rona; Michael R Hayden; Robert N Cole; Christopher A Ross
Mutant huntingtin N-terminal fragments of specific size mediate aggregation and toxicity in neuronal cells.
The Journal of biological chemistry 2009;284(16):10855-67.
2009: Heather A Bruce; Nancy Sachs; Dobrila D Rudnicki; Stephanie G Lin; Virginia L Willour; John Kenneth Cowell; Jeffrey Conroy; Devin E McQuaid; Michael Rossi; Daniel P Gaile; Norma J Nowak; Susan E Holmes; Pamela Sklar; Christopher A Ross; Lynn E DeLisi; Russell L Margolis
Long tandem repeats as a form of genomic copy number variation: structure and length polymorphism of a chromosome 5p repeat in control and schizophrenia populations.
Psychiatric genetics 2009;19(2):64-71.
2009: Yu Wang; L Sternfeld; F Yang; J A Rodriguez; Christopher A Ross; Michael R Hayden; F Carriere; Gang Liu; W Hofer; I Schulz
Enhanced susceptibility to pancreatitis in severe hypertriglyceridaemic lipoprotein lipase-deficient mice and agonist-like function of pancreatic lipase in pancreatic cells.
Gut 2009;58(3):422-30.
2009: Han Seok Ko; Rachel Bailey; Wanli Smith; Zhaohui Liu; Joo-Ho Shin; Yun-Il Lee; Yong-Jie Zhang; Haibing Jiang; Christopher A Ross; Darren J Moore; Winston Patterson; Leonard Petrucelli; Ted M Dawson; Valina Dawson
CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(8):2897-902.
2009: Toshiya Sato; Masami Miura; Mitsunori Yamada; Takayuki Yoshida; Jonathan D Wood; Ikuru Yazawa; Masao Masuda; Takeo Suzuki; Ryong-Moon Shin; Hau-Jie Yau; Fu-Chin Liu; Takayoshi Shimohata; Osamu Onodera; Christopher A Ross; Motoya Katsuki; Hitoshi Takahashi; Masanobu Kano; Toshihiko Aosaki; Shoji Tsuji
Severe neurological phenotypes of Q129 DRPLA transgenic mice serendipitously created by en masse expansion of CAG repeats in Q76 DRPLA mice.
Human molecular genetics 2009;18(4):723-36.
2009: Jonathan D Wood; Franziska Bonath; Shashvita Kumar; Christopher A Ross; Vincent T Cunliffe
Disrupted-in-schizophrenia 1 and neuregulin 1 are required for the specification of oligodendrocytes and neurones in the zebrafish brain.
Human molecular genetics 2009;18(3):391-404.
2009: F Yang; Y Wang; L Sternfeld; J A Rodriguez; Christopher A Ross; Michael R Hayden; F Carriere; G Liu; I Schulz
The role of free fatty acids, pancreatic lipase and Ca+ signalling in injury of isolated acinar cells and pancreatitis model in lipoprotein lipase-deficient mice.
Acta physiologica (Oxford, England) 2009;195(1):13-28.
2008: Jane S Paulsen; Douglas R Langbehn; Julie C Stout; Elizabeth H Aylward; Christopher A Ross; Martha Nance; Mark Guttman; S Johnson; Marcy E MacDonald; Leigh J Beglinger; Kevin Duff; Elise Kayson; K Biglan; Ira Shoulson; David Oakes; Michael R Hayden
Detection of Huntington's disease decades before diagnosis: the Predict-HD study.
Journal of neurology, neurosurgery, and psychiatry 2008;79(8):874-80.
2008: Manchang Liu; Yideng Liang; Srinivasulu Chigurupati; Justin D Lathia; Mikhail V Pletnikov; Zhaoli Sun; Michael T Crow; Christopher A Ross; Mark P Mattson; Hamid Rabb
Acute kidney injury leads to inflammation and functional changes in the brain.
Journal of the American Society of Nephrology : JASN 2008;19(7):1360-70.
2008: WENZHEN DUAN; Qi Peng; Naoki Masuda; ERIC FORD; ERIK TRYGGESTAD; Bruce Ladenheim; Ming Zhao; Jean Lud Cadet; John Wong; Christopher A Ross
Sertraline slows disease progression and increases neurogenesis in N171-82Q mouse model of Huntington's disease.
Neurobiology of disease 2008;30(3):312-22.
2008: Naoki Masuda; Qi Peng; Qing Li; Mali Jiang; Yideng Liang; Xiaofang Wang; Ming Zhao; Wenfei Wang; Christopher A Ross; WENZHEN DUAN
Tiagabine is neuroprotective in the N171-82Q and R6/2 mouse models of Huntington's disease.
Neurobiology of disease 2008;30(3):293-302.
2008: Marcus Kostka; Tobias Högen; Karin M Danzer; Johannes Levin; Matthias Habeck; Andreas Wirth; Richard Wagner; Charles G Glabe; Sabine Finger; Udo Heinzelmann; Patrick Garidel; WENZHEN DUAN; Christopher A Ross; Hans A Kretzschmar; Armin Giese
Single particle characterization of iron-induced pore-forming alpha-synuclein oligomers.
The Journal of biological chemistry 2008;283(16):10992-1003.
2008: John H Krystal; Cameron S Carter; Daniel Geschwind; Husseini K Manji; John March; Eric J Nestler; Jon K Zubieta; Dennis S Charney; David Goldman; Raquel E Gur; Jeffrey A Lieberman; Peter Roy-Byrne; David Rubinow; Stewart A Anderson; Samuel Barondes; Karen F Berman; James Blair; David L Braff; E Sherwood Brown; Joseph Calabrese; William A Carlezon; Edwin H Cook; Richard Davidson; Michael Davis; Robert Desimone; Wayne C Drevets; Ronald S Duman; Susan M Essock; Stephen Faraone; Robert Freedman; Karl J Friston; Joel Gelernter; Barbara Geller; Michael Gill; Elizabeth Gould; Anthony A Grace; Christian Grillon; Ralitza Gueorguieva; Ahmad R Hariri; Robert B Innis; Edward G Jones; Joel E Kleinman; George F Koob; Andrew D Krystal; Ellen Leibenluft; Douglas F Levinson; Pat Levitt; David A Lewis; Israel Liberzon; Barbara K Lipska; Stephen R Marder; Athina Markou; Graeme F Mason; Christopher J McDougle; Bruce McEwen; Francis McMajon; Michael J Meaney; Herbert Y Meltzer; Kathleen Ries Merikangas; Andreas Meyer-Lindenberg; Károly Mirnics; Lisa M Monteggia; Alexander Neumeister; Charles P O'Brien; Michael J Owen; Daniel S Pine; Judy Rapoport; Scott L Rauch; Trevor W Robbins; Jerrold F Rosenbaum; David R Rosenberg; Christopher A Ross; john rush; Harold A Sackeim; Gerard Sanacora; Alan F Schatzberg; Yavin Shaham; Larry J Siever; Trey Sunderland; Laurence H Tecott; Michael E Thase; Richard D Todd; Myrna M Weissman; Rachel Yehuda; Takeo Yoshikawa; Elizabeth A Young; R McCandless
It is time to take a stand for medical research and against terrorism targeting medical scientists.
Biological psychiatry 2008;63(8):725-7.
2008: Dobrila D Rudnicki; Olga Pletnikova; Jean-Paul Vonsattel; Christopher A Ross; Russell L Margolis
A comparison of huntington disease and huntington disease-like 2 neuropathology.
Journal of neuropathology and experimental neurology 2008;67(4):366-74.
2008: Qi Peng; Naoki Masuda; Mali Jiang; Qing Li; Ming Zhao; Christopher A Ross; WENZHEN DUAN
The antidepressant sertraline improves the phenotype, promotes neurogenesis and increases BDNF levels in the R6/2 Huntington's disease mouse model.
Experimental neurology 2008;210(1):154-63.
2008: Zhaohui Liu; Xiaoyue Wang; Yihua Bruce Yu; Xueping Li; Tao Wang; Haibing Jiang; Qiuting Ren; Yuchen Jiao; Akira Sawa; Timothy H Moran; Christopher A Ross; Craig Montell; Wanli Smith
A Drosophila model for LRRK2-linked parkinsonism.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(7):2693-8.
2008: Mikhail V Pletnikov; Y Ayhan; Yanqun Xu; Olga V Nikolskaia; M Ovanesov; Hao Huang; Susumu Mori; Timothy H Moran; Christopher A Ross
Enlargement of the lateral ventricles in mutant DISC1 transgenic mice.
Molecular psychiatry 2008;13(2):115.
2008: Mikhail V Pletnikov; Y Ayhan; Olga V Nikolskaia; Yanqun Xu; Mikhail V Ovanesov; Hao Huang; Susumu Mori; Timothy H Moran; Christopher A Ross
Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia.
Molecular psychiatry 2008;13(2):173-86, 115.
2008: Jason Brandt; Anjeli B Inscore; Julianna Ward; Barnett Shpritz; Adam Rosenblatt; Russell L Margolis; Christopher A Ross
Neuropsychological deficits in Huntington's disease gene carriers and correlates of early "conversion".
The Journal of neuropsychiatry and clinical neurosciences 2008;20(4):466-72.
2007: TAMARA RATOVITSKI; Masayuki Nakamura; James D'Ambola; Ekaterine Chighladze; Yideng Liang; Wenfei Wang; Graham Kyrenia Rona; Michael R Hayden; David R Borchelt; RICKY HIRSCHHORN; Christopher A Ross
N-terminal proteolysis of full-length mutant huntingtin in an inducible PC12 cell model of Huntington's disease.
Cell cycle (Georgetown, Tex.) 2007;6(23):2970-81.
2007: Russell B Williams; Will R Gutekunst; P Matthew Joyner; WENZHEN DUAN; Qing Li; Christopher A Ross; Todd D Williams; Robert H Cichewicz
Bioactivity profiling with parallel mass spectrometry reveals an assemblage of green tea metabolites affording protection against human huntingtin and alpha-synuclein toxicity.
Journal of agricultural and food chemistry 2007;55(23):9450-6.
2007: Haibing Jiang; Yen-Ching Wu; Masayuki Nakamura; Yideng Liang; Yuji Tanaka; Susan E Holmes; Valina Dawson; Ted M Dawson; Christopher A Ross; Wanli Smith
Parkinson's disease genetic mutations increase cell susceptibility to stress: mutant alpha-synuclein enhances H2O2- and Sin-1-induced cell death.
Neurobiology of aging 2007;28(11):1709-17.
2007: Veronica F Colomer Gould; Daniel Goti; Donna Pearce; Guillermo A Gonzalez; Hong Gao; Mario Bermudez de Leon; Nancy A Jenkins; Neal G Copeland; Christopher A Ross; Dale R Brown
A mutant ataxin-3 fragment results from processing at a site N-terminal to amino acid 190 in brain of Machado-Joseph disease-like transgenic mice.
Neurobiology of disease 2007;27(3):362-9.
2007: Shannon A Johnson; Julie C Stout; Andrea C Solomon; Douglas R Langbehn; Elizabeth H Aylward; Christina B Cruce; Christopher A Ross; Martha Nance; Elise Kayson; Elaine Julian-Baros; Michael R Hayden; Karl Kieburtz; Mark Guttman; David Oakes; Ira Shoulson; Leigh J Beglinger; Kevin Duff; Elizabeth Penziner; Jane S Paulsen
Beyond disgust: impaired recognition of negative emotions prior to diagnosis in Huntington's disease.
Brain : a journal of neurology 2007;130(Pt 7):1732-44.
2007: Mikhail V Pletnikov; Yanqun Xu; Mikhail V Ovanesov; Atsushi Kamiya; Akira Sawa; Christopher A Ross
PC12 cell model of inducible expression of mutant DISC1: new evidence for a dominant-negative mechanism of abnormal neuronal differentiation.
Neuroscience research 2007;58(3):234-44.
2007: Andrea C Solomon; Julie C Stout; Shannon A Johnson; Douglas R Langbehn; Elizabeth H Aylward; Jason Brandt; Christopher A Ross; Leigh J Beglinger; Michael R Hayden; Karl Kieburtz; Elise Kayson; Elaine Julian-Baros; Kevin Duff; Mark Guttman; Martha Nance; David Oakes; Ira Shoulson; Elizabeth Penziner; Jane S Paulsen
Verbal episodic memory declines prior to diagnosis in Huntington's disease.
Neuropsychologia 2007;45(8):1767-76.
2007: Gabriele Schilling; Alexandra Klevytska; Andrew T N Tebbenkamp; Katrin Juenemann; Jillian Cooper; Victoria Gonzales; Hilda H Slunt; Michelle Poirer; Christopher A Ross; David R Borchelt
Characterization of huntingtin pathologic fragments in human Huntington disease, transgenic mice, and cell models.
Journal of neuropathology and experimental neurology 2007;66(4):313-20.
2007: Dobrila D Rudnicki; Susan E Holmes; Mark W Lin; Charles A Thornton; Christopher A Ross; Russell L Margolis
Huntington's disease--like 2 is associated with CUG repeat-containing RNA foci.
Annals of neurology 2007;61(3):272-82.
2007: Christopher A Ross; Wanli Smith
Gene-environment interactions in Parkinson's disease.
Parkinsonism & related disorders 2007;13 Suppl 3():S309-15.
2006: Christopher A Ross; Leslie Michels Thompson
Transcription meets metabolism in neurodegeneration.
Nature medicine 2006;12(11):1239-41.
2006: Lyuda Bord; Jeff Wheeler; Matthew Paek; Masoumeh Saleh; Ariel Lyons-Warren; Christopher A Ross; Naoya Sawamura; Akira Sawa
Primate disrupted-in-schizophrenia-1 (DISC1): high divergence of a gene for major mental illnesses in recent evolutionary history.
Neuroscience research 2006;56(3):286-93.
2006: Christopher A Ross; Russell L Margolis; Sarah A J Reading; Mikhail V Pletnikov; Joseph T Coyle
Neurobiology of schizophrenia.
Neuron 2006;52(1):139-53.
2006: Christopher A Ross; Don W Cleveland
Intercellular miscommunication in polyglutamine pathogenesis.
Nature neuroscience 2006;9(10):1205-6.
2006: Wanli Smith; Zhong Pei; Haibing Jiang; Valina Dawson; Ted M Dawson; Christopher A Ross
Kinase activity of mutant LRRK2 mediates neuronal toxicity.
Nature neuroscience 2006;9(10):1231-3.
2006: Susan E Holmes; J S Wentzell; Ana I Seixas; Colleen Callahan; Isabel Silveira; Christopher A Ross; Russell L Margolis
A novel trinucleotide repeat expansion at chromosome 3q26.2 identified by a CAG/CTG repeat expansion detection array.
Human genetics 2006;120(2):193-200.
2006: Haibing Jiang; Michelle A Poirier; Yideng Liang; Zhong Pei; Charlotte E Weiskittel; Wanli Smith; Donald B DeFranco; Christopher A Ross
Depletion of CBP is directly linked with cellular toxicity caused by mutant huntingtin.
Neurobiology of disease 2006;23(3):543-51.
2006: Birgit Schilling; Juliette Gafni; Cameron Torcassi; Xin Cong; Richard H Row; Michelle A LaFevre-Bernt; Michael Cusack; TAMARA RATOVITSKI; RICKY HIRSCHHORN; Christopher A Ross; Bradford W Gibson; Lisa M Ellerby
Huntingtin phosphorylation sites mapped by mass spectrometry. Modulation of cleavage and toxicity.
The Journal of biological chemistry 2006;281(33):23686-97.
2006: Jane S Paulsen; Michael R Hayden; Julie C Stout; Douglas R Langbehn; Elizabeth H Aylward; Christopher A Ross; Mark Guttman; Martha Nance; Karl Kieburtz; David Oakes; Ira Shoulson; Elise Kayson; Shannon Johnson; Elizabeth Penziner
Preparing for preventive clinical trials: the Predict-HD study.
Archives of neurology 2006;63(6):883-90.
2006: Adam Rosenblatt; Kung-Yee Liang; Hong Zhou; Margaret H Abbott; Lisa M Gourley; Russell L Margolis; Jason Brandt; Christopher A Ross
The association of CAG repeat length with clinical progression in Huntington disease.
Neurology 2006;66(7):1016-20.
2006: Byoung-Il Bae; Makoto R Hara; Matthew Cascio; Cheryl L Wellington; Michael R Hayden; Christopher A Ross; Hyo Chol Ha; Xiao-Jiang Li; Solomon H Snyder; Akira Sawa
Mutant huntingtin: nuclear translocation and cytotoxicity mediated by GAPDH.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3405-9.
2006: Yuji Tanaka; Shuichi Igarashi; Masayuki Nakamura; Juliette Gafni; Cameron Torcassi; Gabriele Schilling; Danielle Crippen; Jonathan D Wood; Akira Sawa; Nancy A Jenkins; Neal G Copeland; David R Borchelt; Christopher A Ross; Lisa M Ellerby
Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin.
Neurobiology of disease 2006;21(2):381-91.
2006: Jian-Liang Li; Michael R Hayden; Simon Warby; Alexandra Durr; Patrick J Morrison; Martha Nance; Christopher A Ross; Russell L Margolis; Adam Rosenblatt; Ferdinando Squitieri; Luigi Frati; Estrella Gómez-Tortosa; Carmen Ayuso García; Oksana Suchowersky; Mary Lou Klimek; Ronald J A Trent; Elizabeth McCusker; Andrea Novelletto; Marina Frontali; Jane S Paulsen; Randi Jones; Tetsuo Ashizawa; Alice Lazzarini; Vanessa C Wheeler; Ranjana Prakash; Gang Xu; Luc Djoussé; Jayalakshmi Srinidhi Mysore; Tammy Gillis; Michael Hakky; L Adrienne Cupples; Marie H Saint-Hilaire; Jang-Ho Cha; Steven M Hersch; John B Penney; Madaline B Harrison; Susan L Perlman; Andrea Zanko; Ruth K Abramson; Anthony J Lechich; Ayana Duckett; Karen Marder; P Michael Conneally; James Gusella; Marcy E MacDonald; Richard H Myers
Genome-wide significance for a modifier of age at neurological onset in Huntington's disease at 6q23-24: the HD MAPS study.
BMC medical genetics 2006;7():71.
2005: Wanli Smith; Zhong Pei; Haibing Jiang; Darren J Moore; Yideng Liang; Andrew B West; Valina Dawson; Ted M Dawson; Christopher A Ross
Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(51):18676-81.
2005: Wanli Smith; Haibing Jiang; Zhong Pei; Yuji Tanaka; Hokuto Morita; Akira Sawa; Valina Dawson; Ted M Dawson; Christopher A Ross
Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity.
Human molecular genetics 2005;14(24):3801-11.
2005: Kunlin Jin; Michelle A LaFevre-Bernt; Yunjuan Sun; Sylvia Chen; Juliette Gafni; Danielle Crippen; Anna Logvinova; Christopher A Ross; David A Greenberg; Lisa M Ellerby
FGF-2 promotes neurogenesis and neuroprotection and prolongs survival in a transgenic mouse model of Huntington's disease.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(50):18189-94.
2005: Atsushi Kamiya; Ken-ichiro Kubo; Toshifumi Tomoda; Manabu Takaki; Richard Youn; Yuji Ozeki; Naoya Sawamura; Una Park; Chikako Kudo; Masako Okawa; Christopher A Ross; Mary E Hatten; Kazunori Nakajima; Akira Sawa
A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development.
Nature cell biology 2005;7(12):1167-78.
2005: Andrew B West; Darren J Moore; Saskia Biskup; Artem Bugayenko; Wanli Smith; Christopher A Ross; Valina Dawson; Ted M Dawson
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(46):16842-7.
2005: Christopher A Ross; Michelle A Poirier
Opinion: What is the role of protein aggregation in neurodegeneration?
Nature reviews. Molecular cell biology 2005;6(11):891-8.
2005: Wenfei Wang; WENZHEN DUAN; Shuichi Igarashi; Hokuto Morita; Masayuki Nakamura; Christopher A Ross
Compounds blocking mutant huntingtin toxicity identified using a Huntington's disease neuronal cell model.
Neurobiology of disease 2005;20(2):500-8.
2005: Akira Sawa; Eiichiro Nagata; Siobhan Sutcliffe; Pratima Dulloor; Matthew Cascio; Yuji Ozeki; Sophie Roy; Christopher A Ross; Solomon H Snyder
Huntingtin is cleaved by caspases in the cytoplasm and translocated to the nucleus via perinuclear sites in Huntington's disease patient lymphoblasts.
Neurobiology of disease 2005;20(2):267-74.
2005: Sarah A J Reading; Michael Yassa; Arnold Bakker; Adam C Dziorny; Lisa M Gourley; Venu Yallapragada; Adam Rosenblatt; Russell L Margolis; Elizabeth H Aylward; Jason Brandt; Susumu Mori; Peter C M van Zijl; Susan S Bassett; Christopher A Ross
Regional white matter change in pre-symptomatic Huntington's disease: a diffusion tensor imaging study.
Psychiatry research 2005;140(1):55-62.
2005: Bruce G Jenkins; Ole A Andreassen; Alpaslan Dedeoglu; Blair R Leavitt; Michael R Hayden; David R Borchelt; Christopher A Ross; Robert J Ferrante; M Flint Beal
Effects of CAG repeat length, HTT protein length and protein context on cerebral metabolism measured using magnetic resonance spectroscopy in transgenic mouse models of Huntington's disease.
Journal of neurochemistry 2005;95(2):553-62.
2005: N A Sachs; Akira Sawa; Susan E Holmes; Christopher A Ross; Lynn E DeLisi; Russell L Margolis
A frameshift mutation in Disrupted in Schizophrenia 1 in an American family with schizophrenia and schizoaffective disorder.
Molecular psychiatry 2005;10(8):758-64.
2005: Basant K Puri; Blair R Leavitt; Michael R Hayden; Christopher A Ross; Adam Rosenblatt; J Timothy Greenamyre; Steven M Hersch; Krishna S Vaddadi; A Sword; David F Horrobin; Mehar Manku; Harald Murck
Ethyl-EPA in Huntington disease: a double-blind, randomized, placebo-controlled trial.
Neurology 2005;65(2):286-92.
2005: Byoung-Il Bae; Hong Xu; Shuichi Igarashi; Masahiro Fujimuro; Nishant Agrawal; Yoichi Taya; S Diane Hayward; Timothy H Moran; Craig Montell; Christopher A Ross; Solomon H Snyder; Akira Sawa
p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease.
Neuron 2005;47(1):29-41.
2005: Ana I Seixas; Martin H Maurer; Mark Lin; Colleen Callahan; Alka Ahuja; Tohru Matsuura; Christopher A Ross; Fuki M Hisama; Isabel Silveira; Russell L Margolis
FXTAS, SCA10, and SCA17 in American patients with movement disorders.
American journal of medical genetics. Part A 2005;136(1):87-9.
2005: Wanli Smith; Russell L Margolis; Xiaojie Li; Juan C Troncoso; Michael K Lee; Valina Dawson; Ted M Dawson; Takeshi Iwatsubo; Christopher A Ross
Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(23):5544-52.
2005: Theresa Swift-Scanlan; Jennifer M Coughlin; Tsuo-Hung Lan; James B Potash; Roxann G Ingersoll; J. Raymond DePaulo; Christopher A Ross; Melvin G McInnis
Characterization of CTG/CAG repeats on chromosome 18: a study of bipolar disorder.
Psychiatric genetics 2005;15(2):91-9.
2005: Michelle A Poirier; Haibing Jiang; Christopher A Ross
A structure-based analysis of huntingtin mutant polyglutamine aggregation and toxicity: evidence for a compact beta-sheet structure.
Human molecular genetics 2005;14(6):765-74.
2005: Kah Leong Lim; Katherine C M Chew; Jeanne Tan; Cheng Wang; Kenny K K Chung; Yi Zhang; Yuji Tanaka; Wanli Smith; Simone Engelender; Christopher A Ross; Valina Dawson; Ted M Dawson
Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(8):2002-9.
2005: Jonathan Cornett; Fengli Cao; Chuan-En Wang; Christopher A Ross; Gillian P Bates; Shi-Hua Li; Xiao-Jiang Li
Polyglutamine expansion of huntingtin impairs its nuclear export.
Nature genetics 2005;37(2):198-204.
2005: Naoya Sawamura; Takako Sawamura-Yamamoto; Yuji Ozeki; Christopher A Ross; Akira Sawa
A form of DISC1 enriched in nucleus: altered subcellular distribution in orbitofrontal cortex in psychosis and substance/alcohol abuse.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(4):1187-92.
2005: Gina M Zainelli; Nichole L Dudek; Christopher A Ross; Soo-Youl Kim; Nancy A Muma
Mutant huntingtin protein: a substrate for transglutaminase 1, 2, and 3.
Journal of neuropathology and experimental neurology 2005;64(1):58-65.
2004: Christopher A Ross; Cecile M Pickart
The ubiquitin-proteasome pathway in Parkinson's disease and other neurodegenerative diseases.
Trends in cell biology 2004;14(12):703-11.
2004: Daniel Goti; Scott M Katzen; Jesse Mez; Noam Kurtis; Jennifer Kiluk; Lea Ben-Haïem; Nancy A Jenkins; Neal G Copeland; Akira Kakizuka; Alan H Sharp; Christopher A Ross; Peter R Mouton; Veronica F Colomer Gould
A mutant ataxin-3 putative-cleavage fragment in brains of Machado-Joseph disease patients and transgenic mice is cytotoxic above a critical concentration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(45):10266-79.
2004: Russell L Margolis; Susan E Holmes; Adam Rosenblatt; Lisa M Gourley; Elizabeth O'Hearn; Christopher A Ross; William K Seltzer; Ruth H Walker; Tetsuo Ashizawa; Astrid Rasmussen; Michael R Hayden; Elisabeth W Almqvist; Juliette Harris; Stanley Fahn; Marcy E MacDonald; Jayalakshmi Mysore; Takayoshi Shimohata; Shoji Tsuji; Nicholas T Potter; Kazuhiro Nakaso; Yoshiki Adachi; Kenji Nakashima; Thomas D Bird; Amanda Krause; Penny Greenstein
Huntington's Disease-like 2 (HDL2) in North America and Japan.
Annals of neurology 2004;56(5):670-4.
2004: Gabriele Schilling; Alena V Savonenko; Alexandra Klevytska; Johanna L Morton; Stina M Tucker; Michelle A Poirier; Alexa Gale; Ning Chan; Victoria Gonzales; Hilda H Slunt; Michael Coonfield; Nancy A Jenkins; Neal G Copeland; Christopher A Ross; David R Borchelt
Nuclear-targeting of mutant huntingtin fragments produces Huntington's disease-like phenotypes in transgenic mice.
Human molecular genetics 2004;13(15):1599-610.
2004: Elizabeth H Aylward; Bobbi Sparks; Katherine M Field; Venu Yallapragada; Barnett Shpritz; Adam Rosenblatt; Jason Brandt; Lisa M Gourley; Kung-Yee Liang; Hong Zhou; Russell L Margolis; Christopher A Ross
Onset and rate of striatal atrophy in preclinical Huntington disease.
Neurology 2004;63(1):66-72.
2004: Christopher A Ross
Huntington's disease: new paths to pathogenesis.
Cell 2004;118(1):4-7.
2004: Christopher A Ross; Michelle A Poirier
Protein aggregation and neurodegenerative disease.
Nature medicine 2004;10 Suppl():S10-7.
2004: Eiichiro Nagata; Akira Sawa; Christopher A Ross; Solomon H Snyder
Autophagosome-like vacuole formation in Huntington's disease lymphoblasts.
Neuroreport 2004;15(8):1325-8.
2004: Sarah A J Reading; Adam C Dziorny; Laura A Peroutka; Mathew Schreiber; Lisa M Gourley; Venu Yallapragada; Adam Rosenblatt; Russell L Margolis; James J Pekar; Godfrey D Pearlson; Elizabeth H Aylward; Jason Brandt; Susan S Bassett; Christopher A Ross
Functional brain changes in presymptomatic Huntington's disease.
Annals of neurology 2004;55(6):879-83.
2004: Luc Djoussé; Beth Knowlton; Michael R Hayden; Elisabeth W Almqvist; Ryan R Brinkman; Christopher A Ross; Russell L Margolis; Adam Rosenblatt; Alexandra Durr; Catherine Dode; Patrick J Morrison; Andrea Novelletto; Marina Frontali; Ronald J Trent; Elizabeth A McCusker; Estrella Gómez-Tortosa; David Mayo Cabrero; Randi Jones; Andrea Zanko; Martha Nance; Ruth K Abramson; Oksana Suchowersky; Jane S Paulsen; Madaline B Harrison; Qiong Yang; L Adrienne Cupples; Jayalakshmi Mysore; James Gusella; Marcy E MacDonald; Richard H Myers
Evidence for a modifier of onset age in Huntington disease linked to the HD gene in 4p16.
Neurogenetics 2004;5(2):109-14.
2004: Jin-Suh Kim; Sarah A J Reading; Thomas Brashers-Krug; Vince D Calhoun; Christopher A Ross; Godfrey D Pearlson
Functional MRI study of a serial reaction time task in Huntington's disease.
Psychiatry research 2004;131(1):23-30.
2004: Gabriele Schilling; Alena V Savonenko; Michael Coonfield; Johanna L Morton; Esther Vorovich; Alexa Gale; Christopher Neslon; Ning Chan; Michelle Eaton; David Fromholt; Christopher A Ross; David R Borchelt
Environmental, pharmacological, and genetic modulation of the HD phenotype in transgenic mice.
Experimental neurology 2004;187(1):137-49.
2004: Esti Liani; Allon Eyal; Eyal Avraham; Revital Shemer; Raymonde Szargel; Daniela Berg; Antje Bornemann; Olaf Riess; Christopher A Ross; Ruth Rott; Simone Engelender
Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(15):5500-5.
2004: Gina M Zainelli; Christopher A Ross; Juan C Troncoso; John K Fitzgerald; Nancy A Muma
Calmodulin regulates transglutaminase 2 cross-linking of huntingtin.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(8):1954-61.
2004: Christine M Liszewski; Elizabeth O'Hearn; Iracema Leroi; Lisa M Gourley; Christopher A Ross; Russell L Margolis
Cognitive impairment and psychiatric symptoms in 133 patients with diseases associated with cerebellar degeneration.
The Journal of neuropsychiatry and clinical neurosciences 2004;16(1):109-12.
2004: Hélène Rangone; Ghislaine Poizat; Juan C Troncoso; Christopher A Ross; Marcy E MacDonald; Frédéric Saudou; Sandrine Humbert
The serum- and glucocorticoid-induced kinase SGK inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin.
The European journal of neuroscience 2004;19(2):273-9.
2004: T Tsutsumi; Susan E Holmes; Melvin G McInnis; Akira Sawa; Colleen Callahan; J. Raymond DePaulo; Christopher A Ross; Lynn E DeLisi; Russell L Margolis
Novel CAG/CTG repeat expansion mutations do not contribute to the genetic risk for most cases of bipolar disorder or schizophrenia.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2004;124B(1):15-9.
2003: Elizabeth H Aylward; Adam Rosenblatt; Katherine M Field; Venu Yallapragada; Karl Kieburtz; M McDermott; Lynn A Raymond; Elisabeth W Almqvist; Michael R Hayden; Christopher A Ross
Caudate volume as an outcome measure in clinical trials for Huntington's disease: a pilot study.
Brain research bulletin 2003;62(2):137-41.
2003: Adam Rosenblatt; Margaret H Abbott; Lisa M Gourley; Juan C Troncoso; Russell L Margolis; Jason Brandt; Christopher A Ross
Predictors of neuropathological severity in 100 patients with Huntington's disease.
Annals of neurology 2003;54(4):488-93.
2003: Russell L Margolis; Christopher A Ross
Diagnosis of Huntington disease.
Clinical chemistry 2003;49(10):1726-32.
2003: Jian-Liang Li; Michael R Hayden; Elisabeth W Almqvist; Ryan R Brinkman; Alexandra Durr; Catherine Dodé; Patrick J Morrison; Oksana Suchowersky; Christopher A Ross; Russell L Margolis; Adam Rosenblatt; Estrella Gómez-Tortosa; David Mayo Cabrero; Andrea Novelletto; Marina Frontali; Martha Nance; Ronald J A Trent; Elizabeth McCusker; Randi Jones; Jane S Paulsen; Madeline Harrison; Andrea Zanko; Ruth K Abramson; Ana L Russ; Beth Knowlton; Luc Djoussé; Jayalakshmi S Mysore; Suzanne Tariot; Michael F Gusella; Vanessa C Wheeler; Larry D Atwood; L Adrienne Cupples; Marie Saint-Hilaire; Jang-Ho J Cha; Steven M Hersch; Walter J Koroshetz; James Gusella; Marcy E MacDonald; Richard H Myers
A genome scan for modifiers of age at onset in Huntington disease: The HD MAPS study.
American journal of human genetics 2003;73(3):682-7.
2003: Luc Djoussé; Beth Knowlton; Michael R Hayden; Elisabeth W Almqvist; Ryan R Brinkman; Christopher A Ross; Russell L Margolis; Adam Rosenblatt; Alexandra Durr; Catherine Dode; P J Morrison; Andrea Novelletto; Marina Frontali; Ronald J Trent; Elizabeth A McCusker; Estrella Gómez-Tortosa; D Mayo; R Jones; A Zanko; Martha Nance; Ruth K Abramson; Oksana Suchowersky; Jane S Paulsen; M Harrison; Qiong Yang; L Adrienne Cupples; James Gusella; Marcy E MacDonald; Richard H Myers
Interaction of normal and expanded CAG repeat sizes influences age at onset of Huntington disease.
American journal of medical genetics. Part A 2003;119A(3):279-82.
2003: H Chen; N Wang; Yuqing Huo; Pamela Sklar; Dean F MacKinnon; James B Potash; Francis McMajon; Stylianos E Antonarakis; J. Raymond DePaulo; Christopher A Ross; Melvin G McInnis
Trapping and sequence analysis of 1138 putative exons from human chromosome 18.
Molecular psychiatry 2003;8(6):619-23.
2003: Frank P Marx; Carsten Holzmann; Karsten M Strauss; Lei Li; Olaf Eberhardt; Ellen Gerhardt; Mark Cookson; Dena Hernandez; Matthew J Farrer; Jennifer Kachergus; Simone Engelender; Christopher A Ross; Klaus Berger; Ludger Schöls; Jörg B Schulz; Olaf Riess; Rejko Krüger
Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease.
Human molecular genetics 2003;12(11):1223-31.
2003: Frederick C Nucifora; Lisa M Ellerby; Cheryl L Wellington; Jonathan D Wood; William Joseph Herring; Akira Sawa; Michael R Hayden; Valina Dawson; Ted M Dawson; Christopher A Ross
Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicity.
The Journal of biological chemistry 2003;278(15):13047-55.
2003: Shuichi Igarashi; Hokuto Morita; Kyla M Bennett; Yuji Tanaka; Simone Engelender; Matthew F Peters; Jillian K Cooper; Jonathan D Wood; Akira Sawa; Christopher A Ross
Inducible PC12 cell model of Huntington's disease shows toxicity and decreased histone acetylation.
Neuroreport 2003;14(4):565-8.
2003: Christopher A Ross; Michelle A Poirier; Erich E Wanker; Mario Amzel
Polyglutamine fibrillogenesis: the pathway unfolds.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(1):1-3.
2003: Yuji Ozeki; Toshifumi Tomoda; John Kleiderlein; Atsushi Kamiya; Lyuda Bord; Kumiko Fujii; Masako Okawa; Naoto Yamada; Mary E Hatten; Solomon H Snyder; Christopher A Ross; Akira Sawa
Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(1):289-94.
2003: Gina M Zainelli; Christopher A Ross; Juan C Troncoso; Nancy A Muma
Transglutaminase cross-links in intranuclear inclusions in Huntington disease.
Journal of neuropathology and experimental neurology 2003;62(1):14-24.
2003: Haibing Jiang; Frederick C Nucifora; Christopher A Ross; Donald B DeFranco
Cell death triggered by polyglutamine-expanded huntingtin in a neuronal cell line is associated with degradation of CREB-binding protein.
Human molecular genetics 2003;12(1):1-12.
2002: Michelle A Poirier; Huilin Li; Jed C Macosko; Shuowei Cai; Mario Amzel; Christopher A Ross
Huntingtin spheroids and protofibrils as precursors in polyglutamine fibrilization.
The Journal of biological chemistry 2002;277(43):41032-7.
2002: Banghua Sun; Wei Fan; Aldona Balciunas; Jillian K Cooper; Huiyuan Li; Shirley Steavenson; Paul E Denis; Yunjen Young; Beverly Adler; Larry Daugherty; Raffi Manoukian; Gary Elliott; Wenyan Shen; Jane Talvenheimo; David B Teplow; Mitsuru Haniu; Raj Haldankar; Jette Wypych; Christopher A Ross; Martin Citron; William G Richards
Polyglutamine repeat length-dependent proteolysis of huntingtin.
Neurobiology of disease 2002;11(1):111-22.
2002: Christopher A Ross
Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders.
Neuron 2002;35(5):819-22.
2002: Ruth Luthi-Carter; Andrew D Strand; Sarah A Hanson; Charles Kooperberg; Gabriele Schilling; Albert R La Spada; Diane E Merry; Anne B Young; Christopher A Ross; David R Borchelt; James M Olson
Polyglutamine and transcription: gene expression changes shared by DRPLA and Huntington's disease mouse models reveal context-independent effects.
Human molecular genetics 2002;11(17):1927-37.
2002: Iracema Leroi; Elizabeth O'Hearn; Laura Marsh; Constantine G Lyketsos; Adam Rosenblatt; Christopher A Ross; Jason Brandt; Russell L Margolis
Psychopathology in patients with degenerative cerebellar diseases: a comparison to Huntington's disease.
The American journal of psychiatry 2002;159(8):1306-14.
2002: Cátia S Ribeiro; Katia Carneiro; Christopher A Ross; João R L Menezes; Simone Engelender
Synphilin-1 is developmentally localized to synaptic terminals, and its association with synaptic vesicles is modulated by alpha-synuclein.
The Journal of biological chemistry 2002;277(26):23927-33.
2002: Ingrid Bauer; Martin Gencik; Franco Laccone; Hartmut Peters; Bernhard H F Weber; Elke Holinski Feder; Helga Weirich; Deborah J Morris-Rosendahl; Arndt Rolfs; Alexandra Gencikova; Peter Bauer; Gregor Wenning; Jörg T Epplen; Susan E Holmes; Russell L Margolis; Christopher A Ross; Olaf Riess
Trinucleotide repeat expansions in the junctophilin-3 gene are not found in Caucasian patients with a Huntington's disease-like phenotype.
Annals of neurology 2002;51(5):662.
2002: Luis de Almeida; Christopher A Ross; Diana Zala; Patrick Aebischer; Nicole Deglon
Lentiviral-mediated delivery of mutant huntingtin in the striatum of rats induces a selective neuropathology modulated by polyglutamine repeat size, huntingtin expression levels, and protein length.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(9):3473-83.
2002: Edmond Y W Chan; Jamal Nasir; Claire-Anne Gutekunst; Sarah Coleman; Alan Maclean; Alex Maas; Martina Metzler; Marina Gertsenstein; Christopher A Ross; Andras Nagy; Michael R Hayden
Targeted disruption of Huntingtin-associated protein-1 (Hap1) results in postnatal death due to depressed feeding behavior.
Human molecular genetics 2002;11(8):945-59.
2002: Giovanni Stevanin; Agnès Camuzat; Susan E Holmes; C Julien; R Sahloul; Catherine Dodé; Valerie Hahn-Barma; Christopher A Ross; Russell L Margolis; Alexandra Durr; Alexis Brice
CAG/CTG repeat expansions at the Huntington's disease-like 2 locus are rare in Huntington's disease patients.
Neurology 2002;58(6):965-7.
2002: Koichi Wakabayashi; Simone Engelender; Yuji Tanaka; Makoto Yoshimoto; Fumiaki Mori; Shoji Tsuji; Christopher A Ross; Hitoshi Takahashi
Immunocytochemical localization of synphilin-1, an alpha-synuclein-associated protein, in neurodegenerative disorders.
Acta neuropathologica 2002;103(3):209-14.
2001: H Chen; Christopher A Ross; N Wang; Yuqing Huo; Dean F MacKinnon; James B Potash; Sylvia G Simpson; Francis McMajon; J R DePaulo Jr; Melvin G McInnis
NEDD4L on human chromosome 18q21 has multiple forms of transcripts and is a homologue of the mouse Nedd4-2 gene.
European journal of human genetics : EJHG 2001;9(12):922-30.
2001: Russell L Margolis; Elizabeth O'Hearn; Adam Rosenblatt; Virginia L Willour; Susan E Holmes; ML Franz; Colleen Callahan; HS Hwang; Juan C Troncoso; Christopher A Ross
A disorder similar to Huntington's disease is associated with a novel CAG repeat expansion.
Annals of neurology 2001;50(6):373-80.
2001: Susan E Holmes; Elizabeth O'Hearn; Adam Rosenblatt; Colleen Callahan; HS Hwang; R G Ingersoll-Ashworth; A Fleisher; Giovanni Stevanin; Alexis Brice; Nicholas T Potter; Christopher A Ross; Russell L Margolis
A repeat expansion in the gene encoding junctophilin-3 is associated with Huntington disease-like 2.
Nature genetics 2001;29(4):377-8.
2001: Gabriele Schilling; Michael Coonfield; Christopher A Ross; David R Borchelt
Coenzyme Q10 and remacemide hydrochloride ameliorate motor deficits in a Huntington's disease transgenic mouse model.
Neuroscience letters 2001;315(3):149-53.
2001: Jianguo Xu; Maryse Paquet; Anthony G Lau; J D Wood; Christopher A Ross; Randy A Hall
beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95.
The Journal of biological chemistry 2001;276(44):41310-7.
2001: Susan E Holmes; E O Hearn; Christopher A Ross; Russell L Margolis
SCA12: an unusual mutation leads to an unusual spinocerebellar ataxia.
Brain research bulletin 2001;56(3-4):397-403.
2001: Russell L Margolis; Christopher A Ross
Expansion explosion: new clues to the pathogenesis of repeat expansion neurodegenerative diseases.
Trends in molecular medicine 2001;7(11):479-82.
2001: Kenny K K Chung; Yuesheng Zhang; Kah Leong Lim; Yuji Tanaka; Hui Huang; Jianggang Gao; Christopher A Ross; Valina Dawson; Ted M Dawson
Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease.
Nature medicine 2001;7(10):1144-50.
2001: Russell L Margolis; Elizabeth O'Hearn; Adam Rosenblatt; Virginia L Willour; Susan E Holmes; ML Franz; Colleen Callahan; HS Hwang; Juan C Troncoso; Christopher A Ross
A disorder similar to Huntington's disease is associated with a novel CAG repeat expansion.
Annals of neurology 2001;50(3):373-80.
2001: Jane S Paulsen; H Zhao; Julie C Stout; Ryan R Brinkman; Mark Guttman; Christopher A Ross; Peter G Como; C Manning; Michael R Hayden; Ira Shoulson
Clinical markers of early disease in persons near onset of Huntington's disease.
Neurology 2001;57(4):658-62.
2001: Rina Bandopadhyay; Rohan de Silva; Naheed Khan; Elizabeth Graham; J Vaughan; Simone Engelender; Christopher A Ross; H Morris; C Morris; Nicholas W Wood; Susan E Daniel; Andrew J Lees
No pathogenic mutations in the synphilin-1 gene in Parkinson's disease.
Neuroscience letters 2001;307(2):125-7.
2001: Adam Rosenblatt; Ryan R Brinkman; Kung-Yee Liang; Elisabeth W Almqvist; Russell L Margolis; C Y Huang; M Sherr; ML Franz; Margaret H Abbott; Michael R Hayden; Christopher A Ross
Familial influence on age of onset among siblings with Huntington disease.
American journal of medical genetics 2001;105(5):399-403.
2001: Ole A Andreassen; Robert J Ferrante; H M Huang; Alpaslan Dedeoglu; Lily Park; Kimberly L Ferrante; J Kwon; David R Borchelt; Christopher A Ross; G E Gibson; M Flint Beal
Dichloroacetate exerts therapeutic effects in transgenic mouse models of Huntington's disease.
Annals of neurology 2001;50(1):112-7.
2001: Ole A Andreassen; Alpaslan Dedeoglu; Robert J Ferrante; Bruce G Jenkins; Kimberly L Ferrante; M Thomas; Avi Friedlich; Susan E Browne; Gabriele Schilling; David R Borchelt; Steven M Hersch; Christopher A Ross; M Flint Beal
Creatine increase survival and delays motor symptoms in a transgenic animal model of Huntington's disease.
Neurobiology of disease 2001;8(3):479-91.
2001: Gabriele Schilling; Hyder A Jinnah; Victoria Gonzales; Michael Coonfield; Y Kim; Jonathan D Wood; Donald L Price; Xiao-Jiang Li; Nancy Jenkins; Neal G Copeland; Timothy H Moran; Christopher A Ross; David R Borchelt
Distinct behavioral and neuropathological abnormalities in transgenic mouse models of HD and DRPLA.
Neurobiology of disease 2001;8(3):405-18.
2001: Wanjoo Chun; Mathieu Lesort; Janusz Tucholski; P W Faber; Marcy E MacDonald; Christopher A Ross; Gail Johnson
Tissue transglutaminase selectively modifies proteins associated with truncated mutant huntingtin in intact cells.
Neurobiology of disease 2001;8(3):391-404.
2001: Yuji Tanaka; Simone Engelender; S Igarashi; R K Rao; Tracy J Wanner; Rudolph E Tanzi; Akira Sawa; V L Dawson; Ted M Dawson; Christopher A Ross
Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis.
Human molecular genetics 2001;10(9):919-26.
2001: Wanjoo Chun; Mathieu Lesort; Janusz Tucholski; Christopher A Ross; Gail Johnson
Tissue transglutaminase does not contribute to the formation of mutant huntingtin aggregates.
The Journal of cell biology 2001;153(1):25-34.
2001: Matthew J Farrer; Alain Destée; Clotilde Levecque; Andrew Singleton; Simone Engelender; E Becquet; Vincent Mouroux; Florence Richard; Luc Defebvre; Richard Crook; D Hernandez; Christopher A Ross; John Hardy; Philippe Amouyel; Marie-Christine Chartier-Harlin
Genetic analysis of synphilin-1 in familial Parkinson's disease.
Neurobiology of disease 2001;8(2):317-23.
2001: Frederick C Nucifora; Masayuki Sasaki; Matthew F Peters; Hao Huang; Jillian K Cooper; M Yamada; H Takahashi; Shoji Tsuji; Juan C Troncoso; Valina Dawson; Ted M Dawson; Christopher A Ross
Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity.
Science (New York, N.Y.) 2001;291(5512):2423-8.
2001: Sébastien Holbert; I Denghien; T Kiechle; Adam Rosenblatt; Cheryl L Wellington; Michael R Hayden; Russell L Margolis; Christopher A Ross; Jean Dausset; Robert J Ferrante; Christian Néri
The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1811-6.
2001: Elizabeth O'Hearn; Susan E Holmes; Preston C. Calvert; Christopher A Ross; Russell L Margolis
SCA-12: Tremor with cerebellar and cortical atrophy is associated with a CAG repeat expansion.
Neurology 2001;56(3):299-303.
2001: Matthew F Peters; Christopher A Ross
Isolation of a 40-kDa Huntingtin-associated protein.
The Journal of biological chemistry 2001;276(5):3188-94.
2001: Mitsunori Yamada; J D Wood; T Shimohata; Shintaro Hayashi; Shoji Tsuji; Christopher A Ross; Hitoshi Takahashi
Widespread occurrence of intranuclear atrophin-1 accumulation in the central nervous system neurons of patients with dentatorubral-pallidoluysian atrophy.
Annals of neurology 2001;49(1):14-23.
2001: Hiroto Fujigasaki; I C Verma; Agnès Camuzat; Russell L Margolis; Cecilia Zander; Anne-Sophie Lebre; L Jamot; R Saxena; I Anand; Susan E Holmes; Christopher A Ross; Alexandra Dürr; Alexis Brice
SCA12 is a rare locus for autosomal dominant cerebellar ataxia: a study of an Indian family.
Annals of neurology 2001;49(1):117-21.
2000: Jonathan D Wood; Frederick C Nucifora; K Duan; C Zhang; J Wang; Y Kim; Gabriele Schilling; N Sacchi; Johnson Ming-Yu Liu; Christopher A Ross
Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene product, interacts with ETO/MTG8 in the nuclear matrix and represses transcription.
The Journal of cell biology 2000;150(5):939-48.
2000: H Chen; Yuqing Huo; S Patel; X Zhu; Theresa Swift-Scanlan; Roger H Reeves; J. Raymond DePaulo; Christopher A Ross; Melvin G McInnis
Gene identification using exon amplification on human chromosome 18q21: implications for bipolar disorder.
Molecular psychiatry 2000;5(5):502-9.
2000: Simone Engelender; Tracy J Wanner; John Kleiderlein; K Wakabayashi; S Tsuji; H Takahashi; Roxann Ashworth; Russell L Margolis; Christopher A Ross
Organization of the human synphilin-1 gene, a candidate for Parkinson's disease.
Mammalian genome : official journal of the International Mammalian Genome Society 2000;11(9):763-6.
2000: Jamal Nasir; M J Lafuente; K Duan; Veronica F Colomer Gould; Simone Engelender; R Ingersoll; Russell L Margolis; Christopher A Ross; Michael R Hayden
Human huntingtin-associated protein (HAP-1) gene: genomic organisation and an intragenic polymorphism.
Gene 2000;254(1-2):181-7.
2000: Melvin G McInnis; T Swift-Scanlanl; Amy Mahoney; J Vincent; Greta Verheyen; Tsuo-Hung Lan; Lilijana Oruc; Olaf Riess; Christine Van Broeckhoven; H Chen; James L Kennedy; Dean F MacKinnon; Russell L Margolis; Sylvia G Simpson; Francis McMajon; Elliot S Gershon; John Nurnberger; Theodore Reich; J. Raymond DePaulo; Christopher A Ross
Allelic distribution of CTG18.1 in Caucasian populations: association studies in bipolar disorder, schizophrenia, and ataxia.
Molecular psychiatry 2000;5(4):439-42.
2000: Seth Blackshaw; Akira Sawa; Alan H Sharp; Christopher A Ross; Solomon H Snyder; A A Khan
Type 3 inositol 1,4,5-trisphosphate receptor modulates cell death.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(10):1375-9.
2000: Ruth Luthi-Carter; Andrew D Strand; N L Peters; Steven M Solano; Zane R Hollingsworth; A S Menon; AS Frey; B S Spektor; E B Penney; Gabriele Schilling; Christopher A Ross; David R Borchelt; Stephen J Tapscott; Anne B Young; Jang-Ho Cha; James M Olson
Decreased expression of striatal signaling genes in a mouse model of Huntington's disease.
Human molecular genetics 2000;9(9):1259-71.
2000: Dorotea Rigamonti; Johannes Bauer; C De Fraja; Luciano Conti; Simonetta Sipione; Clara Sciorati; Emilio Clementi; Abigail S Hackam; Michael R Hayden; Yun Li; J K Cooper; Christopher A Ross; Stefano Govoni; Claudius Vincenz; Elena Cattaneo
Wild-type huntingtin protects from apoptosis upstream of caspase-3.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(10):3705-13.
2000: Elizabeth H Aylward; Ann-Marie Codori; Adam Rosenblatt; M Sherr; Jason Brandt; O Colin Stine; Patrick Barta; Godfrey D Pearlson; Christopher A Ross
Rate of caudate atrophy in presymptomatic and symptomatic stages of Huntington's disease.
Movement disorders : official journal of the Movement Disorder Society 2000;15(3):552-60.
2000: Koichi Wakabayashi; S Engelender; M Yoshimoto; Shoji Tsuji; Christopher A Ross; Hidenobu Takahashi
Synphilin-1 is present in Lewy bodies in Parkinson's disease.
Annals of neurology 2000;47(4):521-3.
1999: Melvin G McInnis; Francis McMajon; T Crow; Christopher A Ross; Lynn E DeLisi
Anticipation in schizophrenia: a review and reconsideration.
American journal of medical genetics 1999;88(6):686-93.
1999: Russell L Margolis; Christopher A Ross
Genetics of childhood disorders: IX. Triplet repeat disorders.
Journal of the American Academy of Child and Adolescent Psychiatry 1999;38(12):1598-600.
1999: Susan E Holmes; Elizabeth O'Hearn; Melvin G McInnis; D A Gorelick-Feldman; John Kleiderlein; Colleen Callahan; N G Kwak; R G Ingersoll-Ashworth; M Sherr; A J Sumner; Alan H Sharp; U Ananth; William K Seltzer; MA Boss; A M Vieria-Saecker; J T Epplen; Olaf Riess; Christopher A Ross; Russell L Margolis
Expansion of a novel CAG trinucleotide repeat in the 5' region of PPP2R2B is associated with SCA12.
Nature genetics 1999;23(4):391-2.
1999: Matthew F Peters; Christopher A Ross
Preparation of human cDNas encoding expanded polyglutamine repeats.
Neuroscience letters 1999;275(2):129-32.
1999: Russell L Margolis; Melvin G McInnis; Adam Rosenblatt; Christopher A Ross
Trinucleotide repeat expansion and neuropsychiatric disease.
Archives of general psychiatry 1999;56(11):1019-31.
1999: Akira Sawa; GW Wiegand; J Cooper; Russell L Margolis; Alan H Sharp; Joseph F Lawler; J Timothy Greenamyre; Solomon H Snyder; Christopher A Ross
Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization.
Nature medicine 1999;5(10):1194-8.
1999: Gabriele Schilling; Jonathan D Wood; K Duan; Hilda H Slunt; Victoria Gonzales; M Yamada; Jillian K Cooper; Russell L Margolis; Nancy A Jenkins; Neal G Copeland; H Takahashi; Shoji Tsuji; Donald L Price; David R Borchelt; Christopher A Ross
Nuclear accumulation of truncated atrophin-1 fragments in a transgenic mouse model of DRPLA.
Neuron 1999;24(1):275-86.
1999: Matthew F Peters; Frederick C Nucifora; J Kushi; H C Seaman; Jillian K Cooper; William Joseph Herring; Valina Dawson; Ted M Dawson; Christopher A Ross
Nuclear targeting of mutant Huntingtin increases toxicity.
Molecular and cellular neurosciences 1999;14(2):121-8.
1999: Christopher A Ross; Jonathan D Wood; Gabriele Schilling; Matthew F Peters; Frederick C Nucifora; Jillian K Cooper; Alan H Sharp; Russell L Margolis; David R Borchelt
Polyglutamine pathogenesis.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1999;354(1386):1005-11.
1999: Melvin G McInnis; TS Breschel; Russell L Margolis; Jennifer Chellis; Dean F MacKinnon; Francis McMajon; Sylvia G Simpson; Tsuo-Hung Lan; H Chen; Christopher A Ross; J. Raymond DePaulo
Family-based association analysis of the hSKCa3 potassium channel gene in bipolar disorder.
Molecular psychiatry 1999;4(3):217-9.
1999: Simone Engelender; Z Kaminsky; X Guo; Alan H Sharp; R K Amaravi; John Kleiderlein; Russell L Margolis; Juan C Troncoso; Anthony A Lanahan; Paul F Worley; Valina Dawson; Ted M Dawson; Christopher A Ross
Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions.
Nature genetics 1999;22(1):110-4.
1999: Alan H Sharp; Frederick C Nucifora; O Blondel; CA Sheppard; C Zhang; Solomon H Snyder; James T Russell; David Ryugo; Christopher A Ross
Differential cellular expression of isoforms of inositol 1,4,5-triphosphate receptors in neurons and glia in brain.
The Journal of comparative neurology 1999;406(2):207-20.
1999: Jamal Nasir; Alan Maclean; Simone Engelender; K Duan; Russell L Margolis; John Kleiderlein; Christopher A Ross; Michael R Hayden
Chromosomal localization of the Huntingtin associated protein (HAP-1) gene in mouse and humans with radiation hybrid and interspecific backcross mapping.
Mammalian genome : official journal of the International Mammalian Genome Society 1999;10(4):397-8.
1999: Lisa M Ellerby; RL Andrusiak; Cheryl L Wellington; Abigail S Hackam; Stephanie Propp; J D Wood; A H Sharp; Russell L Margolis; Christopher A Ross; Guy S Salvesen; Michael R Hayden; Dale E Bredesen
Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity.
The Journal of biological chemistry 1999;274(13):8730-6.
1999: Gabriele Schilling; Mark W Becher; Alan H Sharp; Hyder A Jinnah; K Duan; JA Kotzuk; Hilda H Slunt; TAMARA RATOVITSKI; Jillian K Cooper; Nancy A Jenkins; Neal G Copeland; Donald L Price; Christopher A Ross; David R Borchelt
Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin.
Human molecular genetics 1999;8(3):397-407.
1999: Christopher A Ross
Schizophrenia genetics: expansion of knowledge?
Molecular psychiatry 1999;4(1):4-5.
1999: Russell L Margolis; O Colin Stine; C M Ward; ML Franz; Adam Rosenblatt; Colleen Callahan; M Sherr; Christopher A Ross; Nicholas T Potter
Unstable expansion of the CAG trinucleotide repeat in MAB21L1: report of a second pedigree and effect on protein expression.
Journal of medical genetics 1999;36(1):62-4.
1999: Russell L Margolis; O Colin Stine; Colleen Callahan; Adam Rosenblatt; Margaret H Abbott; M Sherr; Christopher A Ross
Two novel single-base-pair substitutions adjacent to the CAG repeat in the huntington disease gene (IT15): implications for diagnostic testing.
American journal of human genetics 1999;64(1):323-6.
1998: John Kleiderlein; PE Nisson; J Jessee; W B Li; K G Becker; M L Derby; Christopher A Ross; Russell L Margolis
CCG repeats in cDNAs from human brain.
Human genetics 1998;103(6):666-73.
1998: Adam Rosenblatt; Russell L Margolis; Mark W Becher; Elizabeth H Aylward; ML Franz; M Sherr; Margaret H Abbott; K Y Lian; Christopher A Ross
Does CAG repeat number predict the rate of pathological changes in Huntington's disease?
Annals of neurology 1998;44(4):708-9.
1998: Kerstin Lindblad; Per-Olof Nylander; Cecilia Zander; Qiu-Ping Yuan; L Ståhle; Christer Engström; Jorune Balciuniene; Ulf Pettersson; TS Breschel; Melvin G McInnis; Christopher A Ross; Rolf Adolfsson; Martin Schalling
Two commonly expanded CAG/CTG repeat loci: involvement in affective disorders?
Molecular psychiatry 1998;3(5):405-10.
1998: M W Becher; Christopher A Ross
Intranuclear neuronal inclusions in DRPLA.
Movement disorders : official journal of the Movement Disorder Society 1998;13(5):852-3.
1998: Catherine E Burgess; Kerstin Lindblad; Ellen Sidransky; Qiu-Ping Yuan; Robert T Long; TS Breschel; Christopher A Ross; Melvin G McInnis; P Lee; Edward I Ginns; Marge Lenane; Sanjiv Kumra; Leslie Jacobsen; Judy Rapoport; Martin Schalling
Large CAG/CTG repeats are associated with childhood-onset schizophrenia.
Molecular psychiatry 1998;3(4):321-7.
1998: Adam Rosenblatt; NG Ranen; David C Rubinsztein; O Colin Stine; Russell L Margolis; MV Wagster; Mark W Becher; A E Rosser; J Leggo; John R Hodges; CK ffrench-Constant; M Sherr; ML Franz; Margaret H Abbott; Christopher A Ross
Patients with features similar to Huntington's disease, without CAG expansion in huntingtin.
Neurology 1998;51(1):215-20.
1998: Jamal Nasir; K Duan; K Nichol; Simone Engelender; Roxann Ashworth; Veronica F Colomer Gould; S Thomas; C M Disteche; Michael R Hayden; Christopher A Ross
Gene structure and map location of the murine homolog of the Huntington-associated protein, Hap1.
Mammalian genome : official journal of the International Mammalian Genome Society 1998;9(7):565-70.
1998: Jonathan D Wood; J Yuan; Russell L Margolis; Veronica F Colomer Gould; K Duan; J Kushi; Z Kaminsky; John Kleiderlein; Alan H Sharp; Christopher A Ross
Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins.
Molecular and cellular neurosciences 1998;11(3):149-60.
1998: Jillian K Cooper; Gabriele Schilling; Matthew F Peters; William Joseph Herring; Alan H Sharp; Z Kaminsky; J Masone; F A Khan; M Delanoy; David R Borchelt; Valina Dawson; Ted M Dawson; Christopher A Ross
Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture.
Human molecular genetics 1998;7(5):783-90.
1998: F Bertaux; A H Sharp; Christopher A Ross; Hans Lehrach; Gillian P Bates; Erich E Wanker
HAP1-huntingtin interactions do not contribute to the molecular pathology in Huntington's disease transgenic mice.
FEBS letters 1998;426(2):229-32.
1998: Cheryl L Wellington; Lisa M Ellerby; Abigail S Hackam; Russell L Margolis; Mark Trifiro; Roshni R Singaraja; Krista McCutcheon; Guy S Salvesen; Stephanie Propp; M Bromm; K J Rowland; T Zhang; Dita M Rasper; Sophie Roy; N Thornberry; Leonard Pinsky; A Kakizuka; Christopher A Ross; Donald W Nicholson; Dale E Bredesen; Michael R Hayden
Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract.
The Journal of biological chemistry 1998;273(15):9158-67.
1998: Mark W Becher; JA Kotzuk; Alan H Sharp; SW Davies; Gillian P Bates; Donald L Price; Christopher A Ross
Intranuclear neuronal inclusions in Huntington's disease and dentatorubral and pallidoluysian atrophy: correlation between the density of inclusions and IT15 CAG triplet repeat length.
Neurobiology of disease 1998;4(6):387-97.
1998: Christopher A Ross; Russell L Margolis; Mark W Becher; Jonathan D Wood; Simone Engelender; Jillian K Cooper; Alan H Sharp
Pathogenesis of neurodegenerative diseases associated with expanded glutamine repeats: new answers, new questions.
Progress in brain research 1998;117():397-419.
1998: Dominik Bengel; U Balling; Gerald Stöber; A Heils; S H Li; Christopher A Ross; G Jungkunz; E Franzek; Helmut Beckmann; Peter Riederer; Klaus-Peter Lesch
Distribution of the B33 CTG repeat polymorphism in a subtype of schizophrenia.
European archives of psychiatry and clinical neuroscience 1998;248(2):78-81.
1998: Elizabeth H Aylward; N B Anderson; FW Bylsma; MV Wagster; Patrick Barta; M Sherr; J Feeney; A Davis; Adam Rosenblatt; Godfrey D Pearlson; Christopher A Ross
Frontal lobe volume in patients with Huntington's disease.
Neurology 1998;50(1):252-8.
1997: Christopher A Ross
Intranuclear neuronal inclusions: a common pathogenic mechanism for glutamine-repeat neurodegenerative diseases?
Neuron 1997;19(6):1147-50.
1997: Simone Engelender; Alan H Sharp; Veronica F Colomer Gould; Mariko Tokito; Anthony A Lanahan; Paul F Worley; Erika L F Holzbaur; Christopher A Ross
Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin.
Human molecular genetics 1997;6(13):2205-12.
1997: ANDREW CAMERON; Frederick C Nucifora; Eric T Fung; D J Livingston; R A Aldape; Christopher A Ross; Solomon H Snyder
FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain.
The Journal of biological chemistry 1997;272(44):27582-8.
1997: Christopher A Ross; Russell L Margolis
Puzzles of psychiatric genetics--new candidate gene approaches.
Molecular psychiatry 1997;2(6):432-3.
1997: TS Breschel; Melvin G McInnis; Russell L Margolis; Giorgio Sirugo; B Corneliussen; Sylvia G Simpson; Francis McMajon; Dean F MacKinnon; Jianfeng Xu; N Pleasant; Yuqing Huo; Roxann Ashworth; C Grundstrom; T Grundstrom; Kenneth K Kidd; J. Raymond DePaulo; Christopher A Ross
A novel, heritable, expanding CTG repeat in an intron of the SEF2-1 gene on chromosome 18q21.1.
Human molecular genetics 1997;6(11):1855-63.
1997: Giorgio Sirugo; Andrew J Pakstis; Kenneth K Kidd; Steven Matthysse; Deborah L Levy; Philip S Holzman; J Párnas; Melvin G McInnis; TS Breschel; Christopher A Ross
Detection of a large CTG/CAG trinucleotide repeat expansion in a Danish schizophrenia kindred.
American journal of medical genetics 1997;74(5):546-8.
1997: Christopher A Ross; Russell L Margolis; Adam Rosenblatt; NG Ranen; Mark W Becher; Elizabeth H Aylward
Huntington disease and the related disorder, dentatorubral-pallidoluysian atrophy (DRPLA).
Medicine 1997;76(5):305-38.
1997: Veronica F Colomer Gould; Simone Engelender; Alan H Sharp; K Duan; Jillian K Cooper; Anthony A Lanahan; Gregory Lyford; Paul F Worley; Christopher A Ross
Huntingtin-associated protein 1 (HAP1) binds to a Trio-like polypeptide, with a rac1 guanine nucleotide exchange factor domain.
Human molecular genetics 1997;6(9):1519-25.
1997: SW Davies; Mark Turmaine; B A Cozens; Marian DiFiglia; Alan H Sharp; Christopher A Ross; Eberhard Scherzinger; Erich E Wanker; L Mangiarini; Gillian P Bates
Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation.
Cell 1997;90(3):537-48.
1997: Mark W Becher; David C Rubinsztein; J Leggo; MV Wagster; O Colin Stine; NG Ranen; ML Franz; Margaret H Abbott; M Sherr; J C MacMillan; L Barron; M E M Porteous; Peter S Harper; Christopher A Ross
Dentatorubral and pallidoluysian atrophy (DRPLA). Clinical and neuropathological findings in genetically confirmed North American and European pedigrees.
Movement disorders : official journal of the Movement Disorder Society 1997;12(4):519-30.
1997: Russell L Margolis; M Roselle Abraham; S B Gatchell; S H Li; A S Kidwai; TS Breschel; O Colin Stine; Colleen Callahan; Melvin G McInnis; Christopher A Ross
cDNAs with long CAG trinucleotide repeats from human brain.
Human genetics 1997;100(1):114-22.
1997: Christopher A Ross; Mark W Becher; Veronica F Colomer Gould; Simone Engelender; Jonathan D Wood; Alan H Sharp
Huntington's disease and dentatorubral-pallidoluysian atrophy: proteins, pathogenesis and pathology.
Brain pathology (Zurich, Switzerland) 1997;7(3):1003-16.
1997: CA Sheppard; PB Simpson; Alan H Sharp; Frederick C Nucifora; Christopher A Ross; G D Lange; James T Russell
Comparison of type 2 inositol 1,4,5-trisphosphate receptor distribution and subcellular Ca2+ release sites that support Ca2+ waves in cultured astrocytes.
Journal of neurochemistry 1997;68(6):2317-27.
1997: Raye L Alford; Russell L Margolis; Christopher A Ross; Carolyn S (Sue) Richards
Southern analysis for detection of CAG repeat expansions associated with dentatorubral pallidoluysian atrophy.
Human genetics 1997;99(3):354-6.
1997: Elizabeth H Aylward; Q Li; O Colin Stine; NG Ranen; M Sherr; Patrick Barta; FW Bylsma; Godfrey D Pearlson; Christopher A Ross
Longitudinal change in basal ganglia volume in patients with Huntington's disease.
Neurology 1997;48(2):394-9.
1996: NG Ranen; C E Peyser; Joseph T Coyle; FW Bylsma; M Sherr; L Day; MARSHAL FOLSTEIN; Jason Brandt; Christopher A Ross; Susan E Folstein
A controlled trial of idebenone in Huntington's disease.
Movement disorders : official journal of the Movement Disorder Society 1996;11(5):549-54.
1996: A A Khan; Mark J Soloski; Alan H Sharp; Gabriele Schilling; DM Sabatini; S H Li; Christopher A Ross; Solomon H Snyder
Lymphocyte apoptosis: mediation by increased type 3 inositol 1,4,5-trisphosphate receptor.
Science (New York, N.Y.) 1996;273(5274):503-7.
1996: Frederick C Nucifora; Alan H Sharp; Sharon L Milgram; Christopher A Ross
Inositol 1,4,5-trisphosphate receptors in endocrine cells: localization and association in hetero- and homotetramers.
Molecular biology of the cell 1996;7(6):949-60.
1996: J Bao; Alan H Sharp; M V Wagster; Mark W Becher; Gabriele Schilling; Christopher A Ross; Valina Dawson; Ted M Dawson
Expansion of polyglutamine repeat in huntingtin leads to abnormal protein interactions involving calmodulin.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(10):5037-42.
1996: Xiao-Jiang Li; Alan H Sharp; S H Li; Ted M Dawson; Solomon H Snyder; Christopher A Ross
Huntingtin-associated protein (HAP1): discrete neuronal localizations in the brain resemble those of neuronal nitric oxide synthase.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(10):4839-44.
1996: Russell L Margolis; O Colin Stine; Melvin G McInnis; NG Ranen; David C Rubinsztein; J Leggo; LORRAINE BRANDO; A S Kidwai; S J Loev; TS Breschel; Colleen Callahan; Sylvia G Simpson; J. Raymond DePaulo; Francis McMajon; S Jain; Eugene S Paykel; C Walsh; Lynn E DeLisi; T J Crow; E F Torrey; R G Ashworth; Jennifer P Macke; Jeremy Nathans; Christopher A Ross
cDNA cloning of a human homologue of the Caenorhabditis elegans cell fate-determining gene mab-21: expression, chromosomal localization and analysis of a highly polymorphic (CAG)n trinucleotide repeat.
Human molecular genetics 1996;5(5):607-16.
1996: Christopher A Ross; Godfrey D Pearlson
Schizophrenia, the heteromodal association neocortex and development: potential for a neurogenetic approach.
Trends in neurosciences 1996;19(5):171-6.
1996: S Jain; J Leggo; Lynn E DeLisi; T J Crow; Russell L Margolis; S H Li; S Goodburn; C Walsh; Eugene S Paykel; Malcolm A Ferguson-Smith; Christopher A Ross; David C Rubinsztein
Analysis of thirteen trinucleotide repeat loci as candidate genes for schizophrenia and bipolar affective disorder.
American journal of medical genetics 1996;67(2):139-46.
1996: F A Khan; Russell L Margolis; S L Loev; Alan H Sharp; S H Li; Christopher A Ross
cDNA cloning and characterization of an atrophin-1 (DRPLA disease gene)-related protein.
Neurobiology of disease 1996;3(2):121-8.
1996: Russell L Margolis; S H Li; W Scott Young; M V Wagster; O Colin Stine; A S Kidwai; R G Ashworth; Christopher A Ross
DRPLA gene (atrophin-1) sequence and mRNA expression in human brain.
Brain research. Molecular brain research 1996;36(2):219-26.
1996: Alan H Sharp; Christopher A Ross
Neurobiology of Huntington's disease.
Neurobiology of disease 1996;3(1):3-15.
1996: Y Paul Goldberg; M A Kalchman; Martina Metzler; Jamal Nasir; J Zeisler; Graham Kyrenia Rona; H B Koide; John R O'Kusky; A H Sharp; Christopher A Ross; Frank R Jirik; Michael R Hayden
Absence of disease phenotype and intergenerational stability of the CAG repeat in transgenic mice expressing the human Huntington disease transcript.
Human molecular genetics 1996;5(2):177-85.
1996: Jason Brandt; FW Bylsma; R Gross; O Colin Stine; NG Ranen; Christopher A Ross
Trinucleotide repeat length and clinical progression in Huntington's disease.
Neurology 1996;46(2):527-31.
1996: T Sasaki; E Billett; Arturas Petronis; D Ying; T Parsons; Fabio Macciardi; Herbert Y Meltzer; J Lieberman; R T Joffe; Christopher A Ross; Melvin G McInnis; S H Li; James L Kennedy
Psychosis and genes with trinucleotide repeat polymorphism.
Human genetics 1996;97(2):244-6.
1996: LORRAINE BRANDO; Robert H Yolken; M M Herman; J E Kleinman; Christopher A Ross; E F Torrey
Analysis of the DRPLA triplet repeat in brain tissue and leukocytes from schizophrenics.
Psychiatric genetics 1996;6(1):1-5.
1996: NG Ranen; JOHN LIPSEY; Glenn J Treisman; Christopher A Ross
Sertraline in the treatment of severe aggressiveness in Huntington's disease.
The Journal of neuropsychiatry and clinical neurosciences 1996;8(3):338-40.
1996: Godfrey D Pearlson; R G Petty; Christopher A Ross; Allen Tien
Schizophrenia: a disease of heteromodal association cortex?
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 1996;14(1):1-17.
1995: Xiao-Jiang Li; S H Li; Alan H Sharp; Frederick C Nucifora; Gabriele Schilling; Anthony A Lanahan; Paul F Worley; Solomon H Snyder; Christopher A Ross
A huntingtin-associated protein enriched in brain with implications for pathology.
Nature 1995;378(6555):398-402.
1995: Russell L Margolis; TS Breschel; S H Li; A S Kidwai; Melvin G McInnis; Christopher A Ross
Polymorphic (AAT) in trinucleotide repeats derived from a human brain cDNA library.
Human genetics 1995;96(4):495-6.
1995: Thomas Sander; Dieter Janz; C Ramel; Christopher A Ross; W Paschen; T Hildmann; Thomas F Wienker; A Bianchi; Gerhard Bauer; U Sailer
Refinement of map position of the human GluR6 kainate receptor gene (GRIK2) and lack of association and linkage with idiopathic generalized epilepsies.
Neurology 1995;45(9):1713-20.
1995: Christopher A Ross
When more is less: pathogenesis of glutamine repeat neurodegenerative diseases.
Neuron 1995;15(3):493-6.
1995: Frederick C Nucifora; S H Li; Sonye K Danoff; A Ullrich; Christopher A Ross
Molecular cloning of a cDNA for the human inositol 1,4,5-trisphosphate receptor type 1, and the identification of a third alternatively spliced variant.
Brain research. Molecular brain research 1995;32(2):291-6.
1995: Gabriele Schilling; Alan H Sharp; S J Loev; M V Wagster; S H Li; O Colin Stine; Christopher A Ross
Expression of the Huntington's disease (IT15) protein product in HD patients.
Human molecular genetics 1995;4(8):1365-71.
1995: Russell L Margolis; TS Breschel; S H Li; A S Kidwai; Stylianos Antonarakis; Melvin G McInnis; Christopher A Ross
Characterization of cDNA clones containing CCA trinucleotide repeats derived from human brain.
Somatic cell and molecular genetics 1995;21(4):279-84.
1995: David C Rubinsztein; W Amos; J Leggo; S Goodburn; S Jain; S H Li; Russell L Margolis; Christopher A Ross; Malcolm A Ferguson-Smith
Microsatellite evolution--evidence for directionality and variation in rate between species.
Nature genetics 1995;10(3):337-43.
1995: S J Loev; Russell L Margolis; W Scott Young; S H Li; Gabriele Schilling; R G Ashworth; Christopher A Ross
Cloning and expression of the rat atrophin-I (DRPLA disease gene) homologue.
Neurobiology of disease 1995;2(3):129-38.
1995: Godfrey D Pearlson; Dean F Wong; Larry E Tune; Christopher A Ross; G A Chase; Jonathan M Links; Robert F Dannals; Alan Wilson; Hayden T Ravert; Henry N Wagner
In vivo D2 dopamine receptor density in psychotic and nonpsychotic patients with bipolar disorder.
Archives of general psychiatry 1995;52(6):471-7.
1995: O Colin Stine; S H Li; N Pleasant; M V Wagster; J C Hedreen; Christopher A Ross
Expression of the mutant allele of IT-15 (the HD gene) in striatum and cortex of Huntington's disease patients.
Human molecular genetics 1995;4(1):15-8.
1994: W Paschen; J C Hedreen; Christopher A Ross
RNA editing of the glutamate receptor subunits GluR2 and GluR6 in human brain tissue.
Journal of neurochemistry 1994;63(5):1596-602.
1994: Kevin T Bush; Robert O Stuart; S H Li; L A Moura; A H Sharp; Christopher A Ross; Sanjay K Nigam
Epithelial inositol 1,4,5-trisphosphate receptors. Multiplicity of localization, solubility, and isoforms.
The Journal of biological chemistry 1994;269(38):23694-9.
1994: O Blondel; M M Moody; A M Depaoli; Alan H Sharp; Christopher A Ross; Hewson H Swift; Graeme I Bell
Localization of inositol trisphosphate receptor subtype 3 to insulin and somatostatin secretory granules and regulation of expression in islets and insulinoma cells.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(16):7777-81.
1994: David C Rubinsztein; J Leggo; S Goodburn; David Barton; Malcolm A Ferguson-Smith; Christopher A Ross; S H Li; R Lofthouse; T J Crow; Lynn E DeLisi
B37 repeats are normal in most schizophrenic patients.
The British journal of psychiatry : the journal of mental science 1994;164(6):851-2.
1994: M V Wagster; J C Hedreen; C E Peyser; Susan E Folstein; Christopher A Ross
Selective loss of [3H]kainic acid and [3H]AMPA binding in layer VI of frontal cortex in Huntington's disease.
Experimental neurology 1994;127(1):70-5.
1994: W Paschen; C D Blackstone; Richard Huganir; Christopher A Ross
Human GluR6 kainate receptor (GRIK2): molecular cloning, expression, polymorphism, and chromosomal assignment.
Genomics 1994;20(3):435-40.
1994: FW Bylsma; C E Peyser; Susan E Folstein; MARSHAL FOLSTEIN; Christopher A Ross; Jason Brandt
EEG power spectra in Huntington's disease: clinical and neuropsychological correlates.
Neuropsychologia 1994;32(2):137-50.
1994: Sonye K Danoff; Christopher A Ross
The inositol trisphosphate receptor gene family: implications for normal and abnormal brain function.
Progress in neuro-psychopharmacology & biological psychiatry 1994;18(1):1-16.
1994: Klaus-Peter Lesch; Gerald Stöber; U Balling; E Franzek; S H Li; Christopher A Ross; M Newman; Helmut Beckmann; Peter Riederer
Triplet repeats in clinical subtypes of schizophrenia: variation at the DRPLA (B 37 CAG repeat) locus is not associated with periodic catatonia.
Journal of neural transmission. General section 1994;98(2):153-7.
1993: Russell L Margolis; S H Li; Christopher A Ross
A rapid method for sequencing trinucleotide repeats.
Nucleic acids research 1993;21(21):4983-4.
1993: O Colin Stine; N Pleasant; ML Franz; Margaret H Abbott; Susan E Folstein; Christopher A Ross
Correlation between the onset age of Huntington's disease and length of the trinucleotide repeat in IT-15.
Human molecular genetics 1993;2(10):1547-9.
1993: Mabel P Duyao; C Ambrose; Richard H Myers; Andrea Novelletto; Francesca Persichetti; Marina Frontali; Susan E Folstein; Christopher A Ross; M Franz; M Abbott
Trinucleotide repeat length instability and age of onset in Huntington's disease.
Nature genetics 1993;4(4):387-92.
1993: Melvin G McInnis; Francis McMajon; G A Chase; Sylvia G Simpson; Christopher A Ross; J. Raymond DePaulo
Anticipation in bipolar affective disorder.
American journal of human genetics 1993;53(2):385-90.
1993: Christopher A Ross; Melvin G McInnis; Russell L Margolis; S H Li
Genes with triplet repeats: candidate mediators of neuropsychiatric disorders.
Trends in neurosciences 1993;16(7):254-60.
1993: S H Li; Melvin G McInnis; Russell L Margolis; Stylianos Antonarakis; Christopher A Ross
Novel triplet repeat containing genes in human brain: cloning, expression, and length polymorphisms.
Genomics 1993;16(3):572-9.
1993: Alan H Sharp; Ted M Dawson; Christopher A Ross; MAJID FOTUHI; R J Mourey; Solomon H Snyder
Inositol 1,4,5-trisphosphate receptors: immunohistochemical localization to discrete areas of rat central nervous system.
Neuroscience 1993;53(4):927-42.
1993: Godfrey D Pearlson; P J Jeffery; G J Harris; Christopher A Ross; M W Fischman; E E Camargo
Correlation of acute cocaine-induced changes in local cerebral blood flow with subjective effects.
The American journal of psychiatry 1993;150(3):495-7.
1993: M J Schell; Sonye K Danoff; Christopher A Ross
Inositol (1,4,5)-trisphosphate receptor: characterization of neuron-specific alternative splicing in rat brain and peripheral tissues.
Brain research. Molecular brain research 1993;17(3-4):212-6.
1992: Xiao-Jiang Li; Michael Forte; R A North; Christopher A Ross; Solomon H Snyder
Cloning and expression of a rat somatostatin receptor enriched in brain.
The Journal of biological chemistry 1992;267(30):21307-12.
1992: Christopher A Ross; Sonye K Danoff; M J Schell; Solomon H Snyder; A Ullrich
Three additional inositol 1,4,5-trisphosphate receptors: molecular cloning and differential localization in brain and peripheral tissues.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(10):4265-9.
1992: R M Zweig; Christopher A Ross; J C Hedreen; C Peyser; J E Cardillo; Susan E Folstein; Donald L Price
Locus coeruleus involvement in Huntington's disease.
Archives of neurology 1992;49(2):152-6.
1991: J C Hedreen; C E Peyser; Susan E Folstein; Christopher A Ross
Neuronal loss in layers V and VI of cerebral cortex in Huntington's disease.
Neuroscience letters 1991;133(2):257-61.
1991: Sonye K Danoff; Christopher D Ferris; C Donath; G A Fischer; S Munemitsu; A Ullrich; Solomon H Snyder; Christopher A Ross
Inositol 1,4,5-trisphosphate receptors: distinct neuronal and nonneuronal forms derived by alternative splicing differ in phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(7):2951-5.
1991: K K Miller; A Verma; Solomon H Snyder; Christopher A Ross
Localization of an endoplasmic reticulum calcium ATPase mRNA in rat brain by in situ hybridization.
Neuroscience 1991;43(1):1-9.
1991: Christopher A Ross; C E Peyser; I Shapiro; MARSHAL FOLSTEIN
Delirium: phenomenologic and etiologic subtypes.
International psychogeriatrics / IPA 1991;3(2):135-47.
1991: Christopher A Ross
CNS arousal systems: possible role in delirium.
International psychogeriatrics / IPA 1991;3(2):353-71.
1990: A Verma; Christopher A Ross; D Verma; S Supattapone; Solomon H Snyder
Rat brain endoplasmic reticulum calcium pools are anatomically and functionally segregated.
Cell regulation 1990;1(10):781-90.
1990: M W MacCumber; Solomon H Snyder; Christopher A Ross
Carboxypeptidase E (enkephalin convertase): mRNA distribution in rat brain by in situ hybridization.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1990;10(8):2850-60.
1990: T Satoh; Christopher A Ross; A Villa; S Supattapone; Tullio Pozzan; Solomon H Snyder; Jacopo Meldolesi
The inositol 1,4,5,-trisphosphate receptor in cerebellar Purkinje cells: quantitative immunogold labeling reveals concentration in an ER subcompartment.
The Journal of cell biology 1990;111(2):615-24.
1990: Christopher A Ross; D Bredt; Solomon H Snyder
Messenger molecules in the cerebellum.
Trends in neurosciences 1990;13(6):216-22.
1990: Godfrey D Pearlson; Christopher A Ross; W D Lohr; B W Rovner; G A Chase; MARSHAL FOLSTEIN
Association between family history of affective disorder and the depressive syndrome of Alzheimer's disease.
The American journal of psychiatry 1990;147(4):452-6.
1990: M W MacCumber; Christopher A Ross; Solomon H Snyder
Endothelin in brain: receptors, mitogenesis, and biosynthesis in glial cells.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(6):2359-63.
1989: M W MacCumber; Christopher A Ross; B M Glaser; Solomon H Snyder
Endothelin: visualization of mRNAs by in situ hybridization provides evidence for local action.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(18):7285-9.
1989: Christopher A Ross; J Meldolesi; T A Milner; T Satoh; S Supattapone; Solomon H Snyder
Inositol 1,4,5-trisphosphate receptor localized to endoplasmic reticulum in cerebellar Purkinje neurons.
Nature 1989;339(6224):468-70.
1989: Christopher A Ross; M W MacCumber; C E Glatt; Solomon H Snyder
Brain phospholipase C isozymes: differential mRNA localizations by in situ hybridization.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(8):2923-7.
1989: R M Zweig; Christopher A Ross; J C Hedreen; Cynthia Steele; J E Cardillo; Peter J Whitehouse; MARSHAL FOLSTEIN; Donald L Price
Neuropathology of aminergic nuclei in Alzheimer's disease.
Progress in clinical and biological research 1989;317():353-65.
1988: Christopher A Ross; G E Wright; Marilyn D Resh; R C Pearson; Solomon H Snyder
Brain-specific src oncogene mRNA mapped in rat brain by in situ hybridization.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(24):9831-5.
1988: R M Zweig; Christopher A Ross; J C Hedreen; Cynthia Steele; J E Cardillo; Peter J Whitehouse; MARSHAL FOLSTEIN; Donald L Price
The neuropathology of aminergic nuclei in Alzheimer's disease.
Annals of neurology 1988;24(2):233-42.
1987: AC Warren; Nikolaos K Robakis; Narayan Ramakrishna; Edward H Koo; Christopher A Ross; A S Robb; MARSHAL FOLSTEIN; Donald L Price; S E Antonarakis
beta-Amyloid gene is not present in three copies in autopsy-validated Alzheimer's disease.
Genomics 1987;1(4):307-12.
1987: Christopher A Ross; J T Curnes; Robert Greenwood
Recurrent vertebrobasilar embolism in an infant with Klippel-Feil anomaly.
Pediatric neurology 1987;3(3):181-3.
1985: Christopher A Ross; D A Ruggiero; D J Reis
Projections from the nucleus tractus solitarii to the rostral ventrolateral medulla.
The Journal of comparative neurology 1985;242(4):511-34.
1985: D A Ruggiero; Christopher A Ross; M Anwar; D H Park; T H Joh; D J Reis
Distribution of neurons containing phenylethanolamine N-methyltransferase in medulla and hypothalamus of rat.
The Journal of comparative neurology 1985;239(2):127-54.
1984: Christopher A Ross; D A Ruggiero; T H Joh; D H Park; D J Reis
Rostral ventrolateral medulla: selective projections to the thoracic autonomic cell column from the region containing C1 adrenaline neurons.
The Journal of comparative neurology 1984;228(2):168-85.
1984: D J Reis; A R Granata; T H Joh; Christopher A Ross; D A Ruggiero; D H Park
Brain stem catecholamine mechanisms in tonic and reflex control of blood pressure.
Hypertension 1984;6(5 Pt 2):II7-15.
1984: Christopher A Ross; D A Ruggiero; M P Meeley; D H Park; T H Joh; D J Reis
A new group of neurons in hypothalamus containing phenylethanolamine N-methyltransferase (PNMT) but not tyrosine hydroxylase.
Brain research 1984;306(1-2):349-53.
1984: Christopher A Ross; D A Ruggiero; D H Park; T H Joh; A F Sved; J Fernandez-Pardal; J M Saavedra; D J Reis
Tonic vasomotor control by the rostral ventrolateral medulla: effect of electrical or chemical stimulation of the area containing C1 adrenaline neurons on arterial pressure, heart rate, and plasma catecholamines and vasopressin.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1984;4(2):474-94.
1984: D J Reis; Christopher A Ross; D A Ruggiero; A R Granata; T H Joh
Role of adrenaline neurons of ventrolateral medulla (the C1 group) in the tonic and phasic control of arterial pressure.
Clinical and experimental hypertension. Part A, Theory and practice 1984;6(1-2):221-41.
1983: Christopher A Ross; D A Ruggiero; T H Joh; D H Park; D J Reis
Adrenaline synthesizing neurons in the rostral ventrolateral medulla: a possible role in tonic vasomotor control.
Brain research 1983;273(2):356-61.
1983: A Del Bo; Christopher A Ross; J F Pardal; J M Saavedra; D J Reis
Fastigial stimulation in rats releases adrenomedullary catecholamines.
The American journal of physiology 1983;244(6):R801-9.
1982: D M Armstrong; Christopher A Ross; V M Pickel; T H Joh; D J Reis
Distribution of dopamine-, noradrenaline-, and adrenaline-containing cell bodies in the rat medulla oblongata: demonstrated by the immunocytochemical localization of catecholamine biosynthetic enzymes.
The Journal of comparative neurology 1982;212(2):173-87.
1981: D A Ruggiero; Christopher A Ross; D J Reis
Projections from the spinal trigeminal nucleus to the entire length of the spinal cord in the rat.
Brain research 1981;225(2):225-33.
1981: Christopher A Ross; D A Ruggiero; D J Reis
Afferent projections to cardiovascular portions of the nucleus of the tractus solitarius in the rat.
Brain research 1981;223(2):402-8.
1981: Christopher A Ross; D M Armstrong; D A Ruggiero; V M Pickel; T H Joh; D J Reis
Adrenaline neurons in the rostral ventrolateral medulla innervate thoracic spinal cord: a combined immunocytochemical and retrograde transport demonstration.
Neuroscience letters 1981;25(3):257-62.
1981: Christopher A Ross; D A Ruggiero; D J Reis
Projections to the spinal cord from neurons close to the ventral surface of the hindbrain in the rat.
Neuroscience letters 1981;21(2):143-8.
1977: M E Trulson; Christopher A Ross; B L Jacobs
Lack of tolerance to the depression of raphe unit activity by lysergic acid diethylamide.
Neuropharmacology 1977;16(11):771-4.
1976: Christopher A Ross; M E Trulson; B L Jacobs
Depletion of brain serotonin following intraventricular 5,7-dihydroxytryptamine fails to disrupt sleep in the rat.
Brain research 1976;114(3):517-23.
1976: M E Trulson; Christopher A Ross; B L Jacobs
Behavioral evidence for the stimulation of CNS serotonin receptors by high doses of LSD.
Psychopharmacology communications 1976;2(2):149-64.