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David Ross

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Raffaele Pasceri; David Ross; David Siegel; Christopher J Moody
Aminophenoxazinones as Inhibitors of Indoleamine 2,3-Dioxygenase (IDO). Synthesis of Exfoliazone and Chandrananimycin A.
Russell R A Kitson; William Lewis; Chuan-Hsin Chang; Adrienne L Davis; Donna L Dehn; Chrisostomos Prodromou; S Mark Roe; David Ross; David Siegel; Huw E L Williams; Rui Xiong; Christopher J Moody
Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90.
David Siegel; Chao Yan; David Ross
NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones.

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2013: Raffaele Pasceri; David Ross; David Siegel; Christopher J Moody
Aminophenoxazinones as Inhibitors of Indoleamine 2,3-Dioxygenase (IDO). Synthesis of Exfoliazone and Chandrananimycin A.
Journal of medicinal chemistry 2013;56(8):3310-7.
2013: Russell R A Kitson; William Lewis; Chuan-Hsin Chang; Adrienne L Davis; Donna L Dehn; Chrisostomos Prodromou; S Mark Roe; David Ross; David Siegel; Huw E L Williams; Rui Xiong; Christopher J Moody
Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90.
Nature chemistry 2013;5(4):307-14.
2012: David Siegel; Chao Yan; David Ross
NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones.
Biochemical pharmacology 2012;83(8):1033-40.
2012: Chao Yan; David Siegel; Aurelie Chilloux; Christopher J Moody; Jeffery Newsome; David Ross
Antitumor indolequinones induced apoptosis in human pancreatic cancer cells via inhibition of thioredoxin reductase and activation of redox signaling.
Molecular pharmacology 2012;81(3):401-10.
2012: David Siegel; Jadwiga K Kepa; David Ross
NAD(P)H:quinone oxidoreductase 1 (NQO1) localizes to the mitotic spindle in human cells.
PloS one 2012;7(9):e44861.
2011: David Ross; Hongfei Zhou; David Siegel
Benzene toxicity: The role of the susceptibility factor NQO1 in bone marrow endothelial cell signaling and function.
Chemico-biological interactions 2011;192(1-2):145-9.
2011: Marine Dufour; Chao Yan; David Siegel; Marie A Colucci; Matthew Jenner; Neil J Oldham; Joe Gomez; Philip Reigan; Yazhuo Li; Cristina I De Matteis; David Ross; Christopher J Moody
Mechanism-based inhibition of quinone reductase 2 (NQO2): selectivity for NQO2 over NQO1 and structural basis for flavoprotein inhibition.
Chembiochem : a European journal of chemical biology 2011;12(8):1203-8.
2011: David Siegel; Biehuoy Shieh; Chao Yan; Jadwiga K Kepa; David Ross
Role for NAD(P)H:quinone oxidoreductase 1 and manganese-dependent superoxide dismutase in 17-(allylamino)-17-demethoxygeldanamycin-induced heat shock protein 90 inhibition in pancreatic cancer cells.
The Journal of pharmacology and experimental therapeutics 2011;336(3):874-80.
2010: Kok Meng Chan; NOR FADILAH RAJAB; David Siegel; Laily Bin Din; David Ross; Salmaan Hussain Inayat-Hussain
Goniothalamin induces coronary artery smooth muscle cells apoptosis: the p53-dependent caspase-2 activation pathway.
Toxicological sciences : an official journal of the Society of Toxicology 2010;116(2):533-48.
2010: Hongfei Zhou; Donna L Dehn; Jadwiga K Kepa; David Siegel; Devon E Scott; Wei Tan; David Ross
NAD(P)H:quinone oxidoreductase 1-compromised human bone marrow endothelial cells exhibit decreased adhesion molecule expression and CD34+ hematopoietic cell adhesion.
The Journal of pharmacology and experimental therapeutics 2010;334(1):260-8.
2010: Salmaan H Inayat-Hussain; H A Ibrahim; E L Siew; NOR FADILAH RAJAB; Kok Meng Chan; David Ross
Modulation of the benzene metabolite hydroquinone induced toxicity: evidence for an important role of fau.
Chemico-biological interactions 2010;184(1-2):310-2.
2010: David Ross; Hongfei Zhou
Relationships between metabolic and non-metabolic susceptibility factors in benzene toxicity.
Chemico-biological interactions 2010;184(1-2):222-8.
2009: Hongfei Zhou; Jadwiga K Kepa; David Siegel; Shigenori Miura; Yuji Hiraki; David Ross
Benzene metabolite hydroquinone up-regulates chondromodulin-I and inhibits tube formation in human bone marrow endothelial cells.
Molecular pharmacology 2009;76(3):579-87.
2009: Chao Yan; Biehuoy Shieh; Philip Reigan; Zhiyong Zhang; Marie A Colucci; Aurélie Chilloux; Jeffery J Newsome; David Siegel; Dan Chan; Christopher J Moody; David Ross
Potent activity of indolequinones against human pancreatic cancer: identification of thioredoxin reductase as a potential target.
Molecular pharmacology 2009;76(1):163-72.
2009: Dimitrios Stagos; Hongfei Zhou; David Ross; Vasilis Vasiliou
4-HNE inhibits tube formation and up-regulates chondromodulin-I in human endothelial cells.
Biochemical and biophysical research communications 2009;379(3):654-8.
2008: Chao Yan; Jadwiga K Kepa; David Siegel; Ian J Stratford; David Ross
Dissecting the role of multiple reductases in bioactivation and cytotoxicity of the antitumor agent 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone (RH1).
Molecular pharmacology 2008;74(6):1657-65.
2008: Wenchang Guo; David Siegel; David Ross
Stability of the Hsp90 inhibitor 17AAG hydroquinone and prevention of metal-catalyzed oxidation.
Journal of pharmaceutical sciences 2008;97(12):5147-57.
2008: Wenchang Guo; Philip Reigan; David Siegel; David Ross
Enzymatic reduction and glutathione conjugation of benzoquinone ansamycin heat shock protein 90 inhibitors: relevance for toxicity and mechanism of action.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(10):2050-7.
2008: Nida S Awadallah; Donna L Dehn; Raj J Shah; S Russell Nash; Yang K Chen; David Ross; Joel S Bentz; Kenneth R Shroyer
NQO1 expression in pancreatic cancer and its potential use as a biomarker.
Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry 2008;16(1):24-31.
2007: Marie A Colucci; Philip Reigan; David Siegel; Aurélie Chilloux; David Ross; Christopher J Moody
Synthesis and evaluation of 3-aryloxymethyl-1,2-dimethylindole-4,7-diones as mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1) activity.
Journal of medicinal chemistry 2007;50(23):5780-9.
2007: Khan Shoeb Zafar; Salmaan H Inayat-Hussain; David Ross
A comparative study of proteasomal inhibition and apoptosis induced in N27 mesencephalic cells by dopamine and MG132.
Journal of neurochemistry 2007;102(3):913-21.
2007: Philip Reigan; Marie A Colucci; David Siegel; Aurélie Chilloux; Christopher J Moody; David Ross
Development of indolequinone mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1): NQO1 inhibition and growth inhibitory activity in human pancreatic MIA PaCa-2 cancer cells.
Biochemistry 2007;46(20):5941-50.
2007: David Siegel; Jadwiga K Kepa; David Ross
Biochemical and genetic analysis of NAD(P)H:quinone oxidoreductase 1 (NQO1).
Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.] 2007;Chapter 4():Unit4.22.
2006: Khan Shoeb Zafar; Salmaan H Inayat-Hussain; David Siegel; A Bao; B Shieh; David Ross
Overexpression of NQO1 protects human SK-N-MC neuroblastoma cells against dopamine-induced cell death.
Toxicology letters 2006;166(3):261-7.
2006: Lanyan Fang; Robert F Battisti; Hao Cheng; Philip Reigan; Yan Xin; Jie Shen; David Ross; Kenneth K Chan; Edward W Martin; Peng George Wang; Duxin Sun
Enzyme specific activation of benzoquinone ansamycin prodrugs using HuCC49DeltaCH2-beta-galactosidase conjugates.
Journal of medicinal chemistry 2006;49(21):6290-7.
2006: Wenchang Guo; Philip Reigan; David Siegel; Joseph Zirrolli; Daniel Gustafson; David Ross
The bioreduction of a series of benzoquinone ansamycins by NAD(P)H:quinone oxidoreductase 1 to more potent heat shock protein 90 inhibitors, the hydroquinone ansamycins.
Molecular pharmacology 2006;70(4):1194-203.
2006: Khan Shoeb Zafar; David Siegel; David Ross
A potential role for cyclized quinones derived from dopamine, DOPA, and 3,4-dihydroxyphenylacetic acid in proteasomal inhibition.
Molecular pharmacology 2006;70(3):1079-86.
2006: Donna L Dehn; David Siegel; Khan Shoeb Zafar; Philip Reigan; Elizabeth Swann; Christopher J Moody; David Ross
5-Methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, exhibits activity against human pancreatic cancer in vitro and in vivo.
Molecular cancer therapeutics 2006;5(7):1702-9.
2006: Hong Zhu; Li Zhang; Ken Itoh; Masayuki Yamamoto; David Ross; Michael A Trush; Jay L Zweier; Yunbo Li
Nrf2 controls bone marrow stromal cell susceptibility to oxidative and electrophilic stress.
Free radical biology & medicine 2006;41(1):132-43.
2006: Vasilis Vasiliou; David Ross; Daniel W Nebert
Update of the NAD(P)H:quinone oxidoreductase (NQO) gene family.
Human genomics 2006;2(5):329-35.
2005: Wenchang Guo; Philip Reigan; David Siegel; Joseph Zirrolli; Daniel Gustafson; David Ross
Formation of 17-allylamino-demethoxygeldanamycin (17-AAG) hydroquinone by NAD(P)H:quinone oxidoreductase 1: role of 17-AAG hydroquinone in heat shock protein 90 inhibition.
Cancer research 2005;65(21):10006-15.
2005: David Ross
Functions and distribution of NQO1 in human bone marrow: potential clues to benzene toxicity.
Chemico-biological interactions 2005;153-154():137-46.
2005: Donna L Dehn; Salmaan H Inayat-Hussain; David Ross
RH1 induces cellular damage in an NAD(P)H:quinone oxidoreductase 1-dependent manner: relationship between DNA cross-linking, cell cycle perturbations, and apoptosis.
The Journal of pharmacology and experimental therapeutics 2005;313(2):771-9.
2005: Salmaan H Inayat-Hussain; David Ross
Intrinsic pathway of hydroquinone induced apoptosis occurs via both caspase-dependent and caspase-independent mechanisms.
Chemical research in toxicology 2005;18(3):420-7.
2004: Daiva Bironaite; David Siegel; Julie L Moran; Babette B Weksler; David Ross
Stimulation of endothelial IL-8 (eIL-8) production and apoptosis by phenolic metabolites of benzene in HL-60 cells and human bone marrow endothelial cells.
Chemico-biological interactions 2004;149(2-3):177-88.
2004: David Ross
Quinone reductases multitasking in the metabolic world.
Drug metabolism reviews 2004;36(3-4):639-54.
2004: Daiva Bironaite; David Siegel; Julie L Moran; Babette B Weksler; David Ross
Stimulation of endothelial IL-8 (eIL-8) production and apoptosis by phenolic metabolites of benzene in HL-60 cells and human bone marrow endothelial cells.
Chemico-biological interactions 2004;149(1):37-49.
2004: Donna L Dehn; Shannon L Winski; David Ross
Development of a new isogenic cell-xenograft system for evaluation of NAD(P)H:quinone oxidoreductase-directed antitumor quinones: evaluation of the activity of RH1.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(9):3147-55.
2004: David Siegel; Daniel L Gustafson; Donna L Dehn; Jin Yi Han; Preecha Boonchoong; Lawrence J Berliner; David Ross
NAD(P)H:quinone oxidoreductase 1: role as a superoxide scavenger.
Molecular pharmacology 2004;65(5):1238-47.
2004: David Ross; David Siegel
NAD(P)H:quinone oxidoreductase 1 (NQO1, DT-diaphorase), functions and pharmacogenetics.
Methods in enzymology 2004;382():115-44.
2003: Jadwiga K Kepa; David Ross
Differential expression of the antioxidant response element within the hNQO1 promoter in NSCLC versus SCLC.
Biochemical and biophysical research communications 2003;311(2):446-53.
2003: Donna L Dehn; David Siegel; Elizabeth Swann; Christopher J Moody; David Ross
Biochemical, cytotoxic, and genotoxic effects of ES936, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, in cellular systems.
Molecular pharmacology 2003;64(3):714-20.
2003: Salmaan H Inayat-Hussain; BO Annuar; Laily Bin Din; AM Ali; David Ross
Loss of mitochondrial transmembrane potential and caspase-9 activation during apoptosis induced by the novel styryl-lactone goniothalamin in HL-60 leukemia cells.
Toxicology in vitro : an international journal published in association with BIBRA 2003;17(4):433-9.
2003: Daniel L Gustafson; David Siegel; Jeffrey C Rastatter; Andrea L Merz; Jacqueline C Parpal; Jadwiga K Kepa; David Ross; Michael E Long
Kinetics of NAD(P)H:quinone oxidoreductase I (NQO1) inhibition by mitomycin C in vitro and in vivo.
The Journal of pharmacology and experimental therapeutics 2003;305(3):1079-86.
2003: Adil Anwar; Donna L Dehn; David Siegel; Jadwiga K Kepa; Luo Jia Tang; Jennifer A Pietenpol; David Ross
Interaction of human NAD(P)H:quinone oxidoreductase 1 (NQO1) with the tumor suppressor protein p53 in cells and cell-free systems.
The Journal of biological chemistry 2003;278(12):10368-73.
2002: Adil Anwar; David Siegel; Jadwiga K Kepa; David Ross
Interaction of the molecular chaperone Hsp70 with human NAD(P)H:quinone oxidoreductase 1.
The Journal of biological chemistry 2002;277(16):14060-7.
2002: Shannon L Winski; Yiannis Koutalos; David L Bentley; David Ross
Subcellular localization of NAD(P)H:quinone oxidoreductase 1 in human cancer cells.
Cancer research 2002;62(5):1420-4.
2001: Shannon L Winski; Margarita Faig; Mario Antonio Bianchet; David Siegel; Elizabeth Swann; K Fung; Mark W Duncan; Christopher J Moody; Mario Amzel; David Ross
Characterization of a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1 by biochemical, X-ray crystallographic, and mass spectrometric approaches.
Biochemistry 2001;40(50):15135-42.
2001: David Siegel; John Ryder; David Ross
NAD(P)H: quinone oxidoreductase 1 expression in human bone marrow endothelial cells.
Toxicology letters 2001;125(1-3):93-8.
2001: Salmaan H Inayat-Hussain; Shannon L Winski; David Ross
Differential involvement of caspases in hydroquinone-induced apoptosis in human leukemic hl-60 and jurkat cells.
Toxicology and applied pharmacology 2001;175(2):95-103.
2001: Margarita Faig; Mario Antonio Bianchet; Shannon L Winski; RH Hargreaves; Christopher J Moody; AR Hudnott; David Ross; Mario Amzel
Structure-based development of anticancer drugs: complexes of NAD(P)H:quinone oxidoreductase 1 with chemotherapeutic quinones.
Structure (London, England : 1993) 2001;9(8):659-67.
2001: Shannon L Winski; Elizabeth Swann; RH Hargreaves; Donna L Dehn; J Butler; Christopher J Moody; David Ross
Relationship between NAD(P)H:quinone oxidoreductase 1 (NQO1) levels in a series of stably transfected cell lines and susceptibility to antitumor quinones.
Biochemical pharmacology 2001;61(12):1509-16.
2001: David Siegel; Adil Anwar; Shannon L Winski; Jadwiga K Kepa; K L Zolman; David Ross
Rapid polyubiquitination and proteasomal degradation of a mutant form of NAD(P)H:quinone oxidoreductase 1.
Molecular pharmacology 2001;59(2):263-8.
2000: David Ross; Jadwiga K Kepa; Shannon L Winski; Howard D Beall; Adil Anwar; David Siegel
NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms.
Chemico-biological interactions 2000;129(1-2):77-97.
2000: David Ross
The role of metabolism and specific metabolites in benzene-induced toxicity: evidence and issues.
Journal of toxicology and environmental health. Part A 2000;61(5-6):357-72.
2000: Salmaan H Inayat-Hussain; SM McGuinness; R Johansson; J Lundstrom; David Ross
Caspase-dependent and -independent mechanisms in apoptosis induced by hydroquinone and catechol metabolites of remoxipride in HL-60 cells.
Chemico-biological interactions 2000;128(1):51-63.
2000: David Siegel; David Ross
Immunodetection of NAD(P)H:quinone oxidoreductase 1 (NQO1) in human tissues.
Free radical biology & medicine 2000;29(3-4):246-53.
2000: L P Schelonka; David Siegel; M W Wilson; A Meininger; David Ross
Immunohistochemical localization of NQO1 in epithelial dysplasia and neoplasia and in donor eyes.
Investigative ophthalmology & visual science 2000;41(7):1617-22.
2000: Margarita Faig; Mario Antonio Bianchet; Paul Talalay; S Chen; Shannon L Winski; David Ross; Mario Amzel
Structures of recombinant human and mouse NAD(P)H:quinone oxidoreductases: species comparison and structural changes with substrate binding and release.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(7):3177-82.
1999: SM McGuinness; R Johansson; J Lundstrom; David Ross
Induction of apoptosis by remoxipride metabolites in HL60 and CD34+/CD19- human bone marrow progenitor cells: potential relevance to remoxipride-induced aplastic anemia.
Chemico-biological interactions 1999;121(3):253-65.
1999: J L Moran; David Siegel; David Ross
A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):8150-5.
1999: Jadwiga K Kepa; David Ross
DT-diaphorase activity in NSCLC and SCLC cell lines: a role for fos/jun regulation.
British journal of cancer 1999;79(11-12):1679-84.
1999: David Siegel; SM McGuinness; Shannon L Winski; David Ross
Genotype-phenotype relationships in studies of a polymorphism in NAD(P)H:quinone oxidoreductase 1.
Pharmacogenetics 1999;9(1):113-21.
1998: Shannon L Winski; RH Hargreaves; J Butler; David Ross
A new screening system for NAD(P)H:quinone oxidoreductase (NQO1)-directed antitumor quinones: identification of a new aziridinylbenzoquinone, RH1, as a NQO1-directed antitumor agent.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(12):3083-8.
1998: Howard D Beall; Shannon L Winski; Elizabeth Swann; AR Hudnott; A S Cotterill; N O'Sullivan; Stephen J Green; R Bien; David Siegel; David Ross; Christopher J Moody
Indolequinone antitumor agents: correlation between quinone structure, rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase, and in vitro cytotoxicity.
Journal of medicinal chemistry 1998;41(24):4755-66.
1998: David Siegel; Wilbur A Franklin; David Ross
Immunohistochemical detection of NAD(P)H:quinone oxidoreductase in human lung and lung tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 1998;4(9):2065-70.
1998: JL Nieusma; David J Claffey; James A Ruth; David Ross
Stereochemical aspects of the conjugation of epoxide metabolites of butadiene with glutathione in rat liver cytosol and freshly isolated rat hepatocytes.
Toxicological sciences : an official journal of the Society of Toxicology 1998;43(2):102-9.
1998: JL Nieusma; David J Claffey; Dennis R Koop; W Chen; Raimund Peter; Sidney D Nelson; James A Ruth; David Ross
Oxidation of 1,3-butadiene to (R)- and (S)-butadiene monoxide by purified recombinant cytochrome P450 2E1 from rabbit, rat and human.
Toxicology letters 1998;95(2):123-9.
1998: Howard D Beall; AR Hudnott; Shannon L Winski; David Siegel; Elizabeth Swann; David Ross; Christopher J Moody
Indolequinone antitumor agents: relationship between quinone structure and rate of metabolism by recombinant human NQO1.
Bioorganic & medicinal chemistry letters 1998;8(5):545-8.
1997: David Siegel; E M Bolton; J A Burr; Daniel C Liebler; David Ross
The reduction of alpha-tocopherolquinone by human NAD(P)H: quinone oxidoreductase: the role of alpha-tocopherolhydroquinone as a cellular antioxidant.
Molecular pharmacology 1997;52(2):300-5.
1997: JL Nieusma; David J Claffey; C Maniglier-Poulet; T Imiolczyk; David Ross; James A Ruth
Stereochemical aspects of 1,3-butadiene metabolism and toxicity in rat and mouse liver microsomes and freshly isolated rat hepatocytes.
Chemical research in toxicology 1997;10(4):450-6.
1997: R D Traver; David Siegel; Howard D Beall; R M Phillips; N W Gibson; W A Franklin; David Ross
Characterization of a polymorphism in NAD(P)H: quinone oxidoreductase (DT-diaphorase).
British journal of cancer 1997;75(1):69-75.
1996: David Ross; David Siegel; D G Schattenberg; X M Sun; J L Moran
Cell-specific activation and detoxification of benzene metabolites in mouse and human bone marrow: identification of target cells and a potential role for modulation of apoptosis in benzene toxicity.
Environmental health perspectives 1996;104 Suppl 6():1177-82.
1996: Daniel L Gustafson; Howard D Beall; E M Bolton; David Ross; Charles A Waldren
Expression of human NAD(P)H: quinone oxidoreductase (DT-diaphorase) in Chinese hamster ovary cells: effect on the toxicity of antitumor quinones.
Molecular pharmacology 1996;50(4):728-35.
1996: J L Moran; David Siegel; X M Sun; David Ross
Induction of apoptosis by benzene metabolites in HL60 and CD34+ human bone marrow progenitor cells.
Molecular pharmacology 1996;50(3):610-5.
1996: David Ross; Howard D Beall; David Siegel; R D Traver; Daniel L Gustafson
Enzymology of bioreductive drug activation.
The British journal of cancer. Supplement 1996;27():S1-8.
1996: X Sun; David Ross
Quinone-induced apoptosis in human colon adenocarcinoma cells via DT-diaphorase mediated bioactivation.
Chemico-biological interactions 1996;100(3):267-76.
1996: Howard D Beall; Y Liu; David Siegel; E M Bolton; N W Gibson; David Ross
Role of NAD(P)H:quinone oxidoreductase (DT-diaphorase) in cytotoxicity and induction of DNA damage by streptonigrin.
Biochemical pharmacology 1996;51(5):645-52.
1996: David Ross
Metabolic basis of benzene toxicity.
European journal of haematology. Supplementum 1996;60():111-8.
1995: Howard D Beall; A M Murphy; David Siegel; R H Hargreaves; J Butler; David Ross
Nicotinamide adenine dinucleotide (phosphate): quinone oxidoreductase (DT-diaphorase) as a target for bioreductive antitumor quinones: quinone cytotoxicity and selectivity in human lung and breast cancer cell lines.
Molecular pharmacology 1995;48(3):499-504.
1995: C Maniglier-Poulet; X Cheng; James A Ruth; David Ross
Metabolism of 1,3-butadiene to butadiene monoxide in mouse and human bone marrow cells.
Chemico-biological interactions 1995;97(2):119-29.
1994: A C Miller; D G Schattenberg; Alvin M Malkinson; David Ross
Decreased content of the IL1 alpha processing enzyme calpain in murine bone marrow-derived macrophages after treatment with the benzene metabolite hydroquinone.
Toxicology letters 1994;74(2):177-84.
1994: D G Schattenberg; WS Stillman; J J Gruntmeir; K M Helm; Richard D Irons; David Ross
Peroxidase activity in murine and human hematopoietic progenitor cells: potential relevance to benzene-induced toxicity.
Molecular pharmacology 1994;46(2):346-51.
1994: Howard D Beall; R T Mulcahy; David Siegel; R D Traver; N W Gibson; David Ross
Metabolism of bioreductive antitumor compounds by purified rat and human DT-diaphorases.
Cancer research 1994;54(12):3196-201.
1994: X Cheng; C Maniglier-Poulet; David Ross; James A Ruth
Solvolytic formation of 1,2-dichloro-3,4-epoxybutane from butadiene monoxide under physiological conditions.
Drug metabolism and disposition: the biological fate of chemicals 1994;22(2):206-10.
1994: David Ross; Howard D Beall; R D Traver; David Siegel; R M Phillips; N W Gibson
Bioactivation of quinones by DT-diaphorase, molecular, biochemical, and chemical studies.
Oncology research 1994;6(10-11):493-500.
1993: David Siegel; Howard D Beall; M Kasai; H Arai; N W Gibson; David Ross
pH-dependent inactivation of DT-diaphorase by mitomycin C and porfiromycin.
Molecular pharmacology 1993;44(6):1128-34.
1993: D Goon; J Matsuura; David Ross
Metabolism and cytotoxicity of trans,trans-muconaldehyde and its derivatives: potential markers of benzene ring cleavage reactions.
Chemico-biological interactions 1993;88(1):37-53.
1993: arungundrum prakash; Howard D Beall; David Ross; N W Gibson
Sequence-selective alkylation and cross-linking induced by mitomycin C upon activation by DT-diaphorase.
Biochemistry 1993;32(21):5518-25.
1993: David Ross; David Siegel; Howard D Beall; arungundrum prakash; R T Mulcahy; N W Gibson
DT-diaphorase in activation and detoxification of quinones. Bioreductive activation of mitomycin C.
Cancer metastasis reviews 1993;12(2):83-101.
1993: D Goon; M Saxena; Y C Awasthi; David Ross
Activity of mouse liver glutathione S-transferases toward trans,trans-muconaldehyde and trans-4-hydroxy-2-nonenal.
Toxicology and applied pharmacology 1993;119(2):175-80.
1992: L G Ganousis; D Goon; T Zyglewska; K K Wu; David Ross
Cell-specific metabolism in mouse bone marrow stroma: studies of activation and detoxification of benzene metabolites.
Molecular pharmacology 1992;42(6):1118-25.
1992: David Siegel; Howard D Beall; C Senekowitsch; M Kasai; H Arai; N W Gibson; David Ross
Bioreductive activation of mitomycin C by DT-diaphorase.
Biochemistry 1992;31(34):7879-85.
1992: N W Gibson; John A Hartley; J Butler; David Siegel; David Ross
Relationship between DT-diaphorase-mediated metabolism of a series of aziridinylbenzoquinones and DNA damage and cytotoxicity.
Molecular pharmacology 1992;42(3):531-6.
1992: J E Smith; David Ross; A B Graham; Graham G Skellern
Isolation and characterization of the S-glucuronide of 4-nitrothiophenol formed by microsomal glucuronyl transferase.
Journal of pharmaceutical and biomedical analysis 1992;10(6):461-3.
1992: D Goon; X Cheng; J A Ruth; Dennis R Petersen; David Ross
Metabolism of trans,trans-muconaldehyde by aldehyde and alcohol dehydrogenases: identification of a novel metabolite.
Toxicology and applied pharmacology 1992;114(1):147-55.
1992: C S Lee; John A Hartley; M D Berardini; J Butler; David Siegel; David Ross; N W Gibson
Alteration in DNA cross-linking and sequence selectivity of a series of aziridinylbenzoquinones after enzymatic reduction by DT-diaphorase.
Biochemistry 1992;31(11):3019-25.
1992: R D Traver; T Horikoshi; Kathleen D Danenberg; T H Stadlbauer; Peter V Danenberg; David Ross; N W Gibson
NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity.
Cancer research 1992;52(4):797-802.
1991: Larry G Thaete; David Siegel; Alvin M Malkinson; G L Forrest; David Ross
NAD(P)H:quinone oxidoreductase (DT-diaphorase) activity and mRNA content in normal and neoplastic mouse lung epithelia.
International journal of cancer. Journal international du cancer 1991;49(1):145-9.
1991: P C Preusch; David Siegel; N W Gibson; David Ross
A note on the inhibition of DT-diaphorase by dicoumarol.
Free radical biology & medicine 1991;11(1):77-80.
1990: David Siegel; N W Gibson; P C Preusch; David Ross
Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells.
Cancer research 1990;50(23):7483-9.
1990: David Siegel; N W Gibson; P C Preusch; David Ross
Metabolism of diaziquone by NAD(P)H:(quinone acceptor) oxidoreductase (DT-diaphorase): role in diaziquone-induced DNA damage and cytotoxicity in human colon carcinoma cells.
Cancer research 1990;50(22):7293-300.
1990: D J Thomas; A Sadler; Subrahmanyam Vangala; D Siegel; Mark J Reasor; Daniel Wierda; David Ross
Bone marrow stromal cell bioactivation and detoxification of the benzene metabolite hydroquinone: comparison of macrophages and fibroblastoid cells.
Molecular pharmacology 1990;37(2):255-62.
1990: David Ross; David Siegel; N W Gibson; D Pacheco; D J Thomas; Mark J Reasor; Daniel Wierda
Activation and deactivation of quinones catalyzed by DT-diaphorase. Evidence for bioreductive activation of diaziquone (AZQ) in human tumor cells and detoxification of benzene metabolites in bone marrow stroma.
Free radical research communications 1990;8(4-6):373-81.
1989: Subrahmanyam Vangala; A Sadler; E Suba; David Ross
Stimulation of in vitro bioactivation of hydroquinone by phenol in bone marrow cells.
Drug metabolism and disposition: the biological fate of chemicals 1989;17(3):348-50.
1988: D Siegel; Alvin M Malkinson; David Ross
Butylated hydroxytoluene (BHT)-mediated increases in NAD(P)H-quinone oxidoreductase (QR) in mouse lung: evidence for the alveolar type II cell as a site of QR activity.
Toxicology and applied pharmacology 1988;96(1):68-74.
1988: R V Bhat; Subrahmanyam Vangala; A Sadler; David Ross
Bioactivation of catechol in rat and human bone marrow cells.
Toxicology and applied pharmacology 1988;94(2):297-304.
1988: A Sadler; Subrahmanyam Vangala; David Ross
Oxidation of catechol by horseradish peroxidase and human leukocyte peroxidase: reactions of o-benzoquinone and o-benzosemiquinone.
Toxicology and applied pharmacology 1988;93(1):62-71.
1988: C S Boyer; David Ross; Dennis R Petersen
Sex and strain differences in the hepatotoxic response to acute cocaine administration in the mouse.
Journal of biochemical toxicology 1988;3():295-307.
1988: D A Donnelly; C S Boyer; Dennis R Petersen; David Ross
Cocaine-induced biochemical changes and cytotoxicity in hepatocytes isolated from both mice and rats.
Chemico-biological interactions 1988;67(1-2):95-104.