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Margalida Rotger

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Chemicals & Drugs

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HIV Infections

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Pharmacogenetics

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Publications

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Maria Dobrinas; Eva Choong; Séverine Crettol; Chantal Csajka; Rachel Lahyani; Rubin Lubomirov; Beatrice Oneda; Margalida Rotger; Chin B Eap
Contribution of CYP2B6 alleles in explaining extreme (S)-methadone plasma levels: a CYP2B6 gene resequencing study.
Rubin Lubomirov; Raquel Martinez; Catia Marzolini; Margalida Rotger; Amalio Telenti; Mona Arab-Alameddine; Enos Bernasconi; Thierry Buclin; Alexandra Calmy; Matthias Cavassini; Chantal Csajka; Laurent A Decosterd; Julia di Iulio; Aurélie Fayet-Mello; Hansjakob Furrer; Monia Guidi; Huldrych F Günthard
Pharmacogenetics-based population pharmacokinetic analysis of etravirine in HIV-1 infected individuals.
Mona Arab-Alameddine; Marta Boffito; Thierry Buclin; Matthias Cavassini; Chantal Csajka; Laurent A Decosterd; Julia di Iulio; Aurélie Fayet-Mello; Huldrych Günthard; Rubin Lubomirov; Michael Neely; Andrew Owen; Katharina Rentsch; Margalida Rotger; Amalio Telenti; Manel Aouri
Population pharmacokinetic analysis and pharmacogenetics of raltegravir in HIV-positive and healthy individuals.

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All Publications

2013: Maria Dobrinas; Eva Choong; Séverine Crettol; Chantal Csajka; Rachel Lahyani; Rubin Lubomirov; Beatrice Oneda; Margalida Rotger; Chin B Eap
Contribution of CYP2B6 alleles in explaining extreme (S)-methadone plasma levels: a CYP2B6 gene resequencing study.
Pharmacogenetics and genomics 2013;23(2):84-93.
2013: Rubin Lubomirov; Raquel Martinez; Catia Marzolini; Margalida Rotger; Amalio Telenti; Mona Arab-Alameddine; Enos Bernasconi; Thierry Buclin; Alexandra Calmy; Matthias Cavassini; Chantal Csajka; Laurent A Decosterd; Julia di Iulio; Aurélie Fayet-Mello; Hansjakob Furrer; Monia Guidi; Huldrych F Günthard
Pharmacogenetics-based population pharmacokinetic analysis of etravirine in HIV-1 infected individuals.
Pharmacogenetics and genomics 2013;23(1):9-18.
2012: Mona Arab-Alameddine; Marta Boffito; Thierry Buclin; Matthias Cavassini; Chantal Csajka; Laurent A Decosterd; Julia di Iulio; Aurélie Fayet-Mello; Huldrych Günthard; Rubin Lubomirov; Michael Neely; Andrew Owen; Katharina Rentsch; Margalida Rotger; Amalio Telenti; Manel Aouri
Population pharmacokinetic analysis and pharmacogenetics of raltegravir in HIV-positive and healthy individuals.
Antimicrobial agents and chemotherapy 2012;56(6):2959-66.
2012: M Guidi; Margalida Rotger; Amalio Telenti; Manel Aouri; Mona Arab-Alameddine; Thierry Buclin; Chantal Csajka; Laurent A Decosterd
Dosage optimization of treatments using population pharmacokinetic modeling and simulation.
Chimia 2012;66(5):291-5.
2012: Tracy R Glass; Huldrych Günthard; Bernard Hirschel; Catia Marzolini; Dunja Nicca; Martin Rickenbach; Margalida Rotger; Amalio Telenti; Gilles Wandeler; Manuel Battegay; Enos Bernasconi; Heiner C Bucher; Chantal Csajka; Laurent A Decosterd
Determinants of sustained viral suppression in HIV-infected patients with self-reported poor adherence to antiretroviral therapy.
PloS one 2012;7(1):e29186.
2011: Margalida Rotger; Judith Dalmau; Andri Rauch; Paul McLaren; Steven E Bosinger; Raquel Martinez; Netanya G Sandler; Annelys Roque; Julia Liebner; Manuel Battegay; Enos Bernasconi; Patrick Descombes; Itziar Erkizia; Jacques Fellay; Bernard Hirschel; Jose M Miró; Eduard Palou; Matthias Hoffmann; Marta Massanella; Julià Blanco; Matthew Woods; Huldrych F Günthard; Paul de Bakker; Daniel C Douek; Guido Silvestri; Javier Martinez-Picado; Amalio Telenti
Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque.
The Journal of clinical investigation 2011;121(6):2391-400.
2011: Julia di Iulio; Angela Ciuffi; Karen Fitzmaurice; Dermot Kelleher; Margalida Rotger; Jacques Fellay; Raquel Martinez; Sara Pulit; Hansjakob Furrer; Huldrych Günthard; Manuel Battegay; Enos Bernasconi; Patrick Schmid; Bernard Hirschel; Eleanor Barnes; Paul Klenerman; Amalio Telenti; Andri Rauch
Estimating the net contribution of interleukin-28B variation to spontaneous hepatitis C virus clearance.
Hepatology (Baltimore, Md.) 2011;53(5):1446-54.
2011: Julia di Iulio; Margalida Rotger
Pharmacogenomics: what is next?
Frontiers in pharmacology 2011;2():86.
2010: Margalida Rotger; Thomas Gsponer; Raquel Martinez; Patrick Taffé; Luigia Elzi; Pietro Vernazza; Matthias Cavassini; Enos Bernasconi; Bernard Hirschel; Hansjakob Furrer; Rainer Weber; bruno ledergerber; Matthias Egger; Amalio Telenti; Philip E Tarr
Impact of single nucleotide polymorphisms and of clinical risk factors on new‐onset diabetes mellitus in HIV‐infected individuals.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2010;51(9):1090-8.
2010: Philip E Tarr; Margalida Rotger; Amalio Telenti
Dyslipidemia in HIV-infected individuals: from pharmacogenetics to pharmacogenomics.
Pharmacogenomics 2010;11(4):587-94.
2010: Margalida Rotger; Kristen K Dang; Jacques Fellay; Erin L Heinzen; Sheng Feng; Patrick Descombes; Kevin V Shianna; Dongliang Ge; Huldrych F Günthard; David B Goldstein; Amalio Telenti
Genome-wide mRNA expression correlates of viral control in CD4+ T-cells from HIV-1-infected individuals.
PLoS pathogens 2010;6(2):e1000781.
2009: Margalida Rotger; Cornelia Bayard; Patrick Taffé; Raquel Martinez; Matthias Cavassini; Enos Bernasconi; Manuel Battegay; Bernard Hirschel; Hansjakob Furrer; Andrea Witteck; Rainer Weber; bruno ledergerber; Amalio Telenti; Philip E Tarr
Contribution of genome-wide significant single-nucleotide polymorphisms and antiretroviral therapy to dyslipidemia in HIV-infected individuals: a longitudinal study.
Circulation. Cardiovascular genetics 2009;2(6):621-8.
2009: Thomas J Urban; Amy C Weintrob; Jacques Fellay; Sara Colombo; Kevin V Shianna; Curtis Gumbs; Margalida Rotger; Kimberly Pelak; Kristen K Dang; Roger Detels; Jeremy J Martinson; Stephen J O'Brien; Norman L Letvin; Andrew J McMichael; Barton F Haynes; Mary Carrington; Amalio Telenti; Nelson L Michael; David B Goldstein
CCL3L1 and HIV/AIDS susceptibility.
Nature medicine 2009;15(10):1110-2.
2009: M Arab-Alameddine; J Di Iulio; Thierry Buclin; Margalida Rotger; R Lubomirov; M Cavassini; A Fayet; Laurent A Décosterd; Chin B Eap; Jérôme Biollaz; Amalio Telenti; Chantal Csajka
Pharmacogenetics-based population pharmacokinetic analysis of efavirenz in HIV-1-infected individuals.
Clinical pharmacology and therapeutics 2009;85(5):485-94.
2009: Julia di Iulio; Aurélie Fayet; Mona Arab-Alameddine; Margalida Rotger; Rubin Lubomirov; Matthias Cavassini; Hansjakob Furrer; Huldrych F Günthard; Sara Colombo; Chantal Csajka; Chin B Eap; Laurent A Decosterd; Amalio Telenti
In vivo analysis of efavirenz metabolism in individuals with impaired CYP2A6 function.
Pharmacogenetics and genomics 2009;19(4):300-9.
2008: Sara Colombo; Andri Rauch; Margalida Rotger; Jacques Fellay; Raquel Martinez; Christoph Fux; Christine Thurnheer; Huldrych Günthard; David B Goldstein; Hansjakob Furrer; Amalio Telenti
The HCP5 single-nucleotide polymorphism: a simple screening tool for prediction of hypersensitivity reaction to abacavir.
The Journal of infectious diseases 2008;198(6):864-7.
2008: Rubin Lubomirov; Amalio Telenti; Margalida Rotger
[General concepts and study methods in pharmacogenetics].
Enfermedades infecciosas y microbiología clínica 2008;26 Suppl 6():4-9.
2008: Margalida Rotger; Amalio Telenti
Optimizing efavirenz treatment: CYP2B6 genotyping or therapeutic drug monitoring?
European journal of clinical pharmacology 2008;64(4):335-6.
2007: Corinne Loeuillet; Michael Weale; Samuel Deutsch; Margalida Rotger; Nicole Soranzo; Josiane Wyniger; Guillaume Lettre; Yann Dupré; Delphine Thuillard; Jacques Beckmann; Stylianos E Antonarakis; David B Goldstein; Amalio Telenti
Promoter polymorphisms and allelic imbalance in ABCB1 expression.
Pharmacogenetics and genomics 2007;17(11):951-9.
2007: Margalida Rotger; Maria Saumoy; Kunlin Zhang; Markus Flepp; Roland Sahli; Laurent A Decosterd; Amalio Telenti
Partial deletion of CYP2B6 owing to unequal crossover with CYP2B7.
Pharmacogenetics and genomics 2007;17(10):885-90.
2007: Margalida Rotger; Heike Tegude; Sara Colombo; M Cavassini; Hansjakob Furrer; Laurent A Décosterd; Julia Blievernicht; Tanja Saussele; Huldrych Günthard; Matthias Schwab; Michel Eichelbaum; Amalio Telenti; Uli Zanger
Predictive value of known and novel alleles of CYP2B6 for efavirenz plasma concentrations in HIV-infected individuals.
Clinical pharmacology and therapeutics 2007;81(4):557-66.
2007: Margalida Rotger; Sara Colombo; Hansjakob Furrer; Laurent A Décosterd; Thierry Buclin; Amalio Telenti
Does tenofovir influence efavirenz pharmacokinetics?
Antiviral therapy 2007;12(1):115-8.
2006: Margalida Rotger; Rubin Lubomirov; Sonia Rodríguez-Novoa; Pablo Barreiro
[Pharmacogenetics of antiretroviral therapy.].
Enfermedades infecciosas y microbiología clínica 2006;24 Suppl 2():13-8.
2006: Margalida Rotger; Chantal Csajka; Amalio Telenti
Genetic, ethnic, and gender differences in the pharmacokinetics of antiretroviral agents.
Current HIV/AIDS reports 2006;3(3):118-25.
2005: Margalida Rotger; Patrick Taffe; Gabriela Bleiber; Huldrych F Gunthard; Hansjakob Furrer; Pietro Vernazza; Henning Drechsler; Enos Bernasconi; Martin Rickenbach; Amalio Telenti
Gilbert syndrome and the development of antiretroviral therapy-associated hyperbilirubinemia.
The Journal of infectious diseases 2005;192(8):1381-6.
2005: Sara Colombo; Nicole Soranzo; Margalida Rotger; Raimund Sprenger; Gabriela Bleiber; Hansjakob Furrer; Thierry Buclin; David Goldstein; Laurent A Décosterd; Amalio Telenti
Influence of ABCB1, ABCC1, ABCC2, and ABCG2 haplotypes on the cellular exposure of nelfinavir in vivo.
Pharmacogenetics and genomics 2005;15(9):599-608.
2005: Margalida Rotger; Andrej Trampuz; Kerryl E Piper; James M Steckelberg; Robin Patel
Phenotypic and genotypic mupirocin resistance among Staphylococci causing prosthetic joint infection.
Journal of clinical microbiology 2005;43(8):4266-8.
2005: Mark S Rouse; Margalida Rotger; Kerryl E Piper; James M Steckelberg; Matthew Scholz; Jeffrey Andrews; Robin Patel
In vitro and in vivo evaluations of the activities of lauric acid monoester formulations against Staphylococcus aureus.
Antimicrobial agents and chemotherapy 2005;49(8):3187-91.
2005: Philip E Tarr; Patrick Taffé; Gabriela Bleiber; Hansjakob Furrer; Margalida Rotger; Raquel Martinez; Bernard Hirschel; Manuel Battegay; Rainer Weber; Pietro Vernazza; Enos Bernasconi; Roger Darioli; Martin Rickenbach; bruno ledergerber; Amalio Telenti
Modeling the influence of APOC3, APOE, and TNF polymorphisms on the risk of antiretroviral therapy-associated lipid disorders.
The Journal of infectious diseases 2005;191(9):1419-26.
2005: Margalida Rotger; Sara Colombo; Hansjakob Furrer; Gabriela Bleiber; Thierry Buclin; Belle L Lee; Olivia Keiser; Jérôme Biollaz; Laurent A Décosterd; Amalio Telenti
Influence of CYP2B6 polymorphism on plasma and intracellular concentrations and toxicity of efavirenz and nevirapine in HIV-infected patients.
Pharmacogenetics and genomics 2005;15(1):1-5.