Username

Password

Forgot Password?

Preview

Sign-in free and Explore the Exciting World of BiomedExperts:

Over 1.500.000 Profiles
More than 1.800 Organizations worldwide
State of the Art Network Visualizations

Manage your own Profile
Locate Experts in your Country/Region
Locate Experts in your 1. and 2. Level Network
Connect to Experts Worldwide

NetworkView

David Roth

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Physiology

Chemicals & Drugs

Living Beings

Anatomy

CHO Cells

Concepts & Ideas

Sign-in to see full Profile

Network (preview)

Co-Publications
Name
11
Brandt, Vicky
10
Bogue, MA
10
Zhu, Chengming
6
Landree, Mark
6
Han, JO
5
Huye, Leslie
5
Lee, Gregory
4
Neiditch, Matthew
4
Gellert, Martin
4
Kale, SB
4
Bosma, Melvin
4
Wang, C
4
Wilson, John
4
Purugganan, Mary
3
Steen, SB

Sign-in to see all Coauthors

Publications

TOP 3
Deriano Ludovic; Stracker Travis H; Baker Annalee; Petrini John H J; Roth David B
Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates.
Stracker Travis H; Williams Bret R; Deriano Ludovic; Theunissen Jan W; Adelman Carrie A; Roth David B; Petrini John H J
Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability.
Brandt Vicky L; Roth David B
Recent insights into the formation of RAG-induced chromosomal translocations.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of David Roth (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2009: Deriano Ludovic; Stracker Travis H; Baker Annalee; Petrini John H J; Roth David B
Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates.
Molecular cell 2009;34(1):13-25.
2009: Stracker Travis H; Williams Bret R; Deriano Ludovic; Theunissen Jan W; Adelman Carrie A; Roth David B; Petrini John H J
Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability.
Molecular and cellular biology 2009;29(2):503-14.
2009: Brandt Vicky L; Roth David B
Recent insights into the formation of RAG-induced chromosomal translocations.
Advances in experimental medicine and biology 2009;650():32-45.
2008: Wong Serre-Yu; Lu Catherine P; Roth David B
A RAG1 mutation found in Omenn syndrome causes coding flank hypersensitivity: a novel mechanism for antigen receptor repertoire restriction.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(6):4124-30.
2008: Lu Catherine P; Posey Jennifer E; Roth David B
Understanding how the V(D)J recombinase catalyzes transesterification: distinctions between DNA cleavage and transposition.
Nucleic acids research 2008;36(9):2864-73.
2008: Dynan William; Takeda Yoshihiko; Roth David; Bao Gang
Understanding and re-engineering nucleoprotein machines to cure human disease.
Nanomedicine (London, England) 2008;3(1):93-105.
2008: Brandt Vicky L; Roth David B
G.O.D.'s Holy Grail: discovery of the RAG proteins.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(1):3-4.
2007: Corneo Barbara; Wendland Rebecca L; Deriano Ludovic; Cui Xiaoping; Klein Isaac A; Wong Serre-Yu; Arnal Suzzette; Holub Abigail J; Weller Geoffrey R; Pancake Bette A; Shah Sundeep; Brandt Vicky L; Meek Katheryn; Roth David B
Rag mutations reveal robust alternative end joining.
Nature 2007;449(7161):483-6.
2007: Arnal Suzzette M; Roth David B
Excised V(D)J recombination byproducts threaten genomic integrity.
Trends in immunology 2007;28(7):289-92.
2007: Wong Serre-Yu; Roth David B
Murine models of Omenn syndrome.
The Journal of clinical investigation 2007;117(5):1213-6.
2006: Posey Jennifer E; Pytlos Malgorzata J; Sinden Richard R; Roth David B
Target DNA structure plays a critical role in RAG transposition.
PLoS biology 2006;4(11):e350.
2006: Lu Catherine P; Sandoval Hector; Brandt Vicky L; Rice Phoebe A; Roth David B
Amino acid residues in Rag1 crucial for DNA hairpin formation.
Nature structural & molecular biology 2006;13(11):1010-5.
2004: Weller Geoffrey R; Brandt Vicky L; Roth David B
Doing more with less in bacterial DNA repair.
Nature structural & molecular biology 2004;11(12):1158-9.
2004: Lee Gregory S; Brandt Vicky L; Roth David B
B cell development leads off with a base hit: dU:dG mismatches in class switching and hypermutation.
Molecular cell 2004;16(4):505-8.
2004: Brandt Vicky L; Roth David B
V(D)J recombination: how to tame a transposase.
Immunological reviews 2004;200():249-60.
2004: Posey Jennifer E; Brandt Vicky L; Roth David B
Paradigm switching in the germinal center.
Nature immunology 2004;5(5):476-7.
2004: Lee Gregory S; Neiditch Matthew B; Salus Sandra S; Roth David B
RAG proteins shepherd double-strand breaks to a specific pathway, suppressing error-prone repair, but RAG nicking initiates homologous recombination.
Cell 2004;117(2):171-84.
2004: Sandor Zoltan; Calicchio Monica L; Sargent R Geoffrey; Roth David B; Wilson John H
Distinct requirements for Ku in N nucleotide addition at V(D)J- and non-V(D)J-generated double-strand breaks.
Nucleic acids research 2004;32(6):1866-73.
2003: Roth David B
Restraining the V(D)J recombinase.
Nature reviews. Immunology 2003;3(8):656-66.
2003: Zhang Zhixin; Zemlin Michael; Wang Yui-Hsi; Munfus Delicia; Huye Leslie E; Findley Harry W; Bridges S Louis; Roth David B; Burrows Peter D; Cooper Max D
Contribution of Vh gene replacement to the primary B cell repertoire.
Immunity 2003;19(1):21-31.
2003: Brandt Vicky L; Roth David B
Artemis: guarding small children and, now, the genome.
The Journal of clinical investigation 2003;111(3):315-6.
2002: Bender Carla F; Sikes Michael L; Sullivan Ruth; Huye Leslie Erskine; Le Beau Michelle M; Roth David B; Mirzoeva Olga K; Oltz Eugene M; Petrini John H J
Cancer predisposition and hematopoietic failure in Rad50(S/S) mice.
Genes & development 2002;16(17):2237-51.
2002: Roth David B
Amplifying mechanisms of lymphomagenesis.
Molecular cell 2002;10(1):1-2.
2002: Huye Leslie E; Purugganan Mary M; Jiang Ming-Ming; Roth David B
Mutational analysis of all conserved basic amino acids in RAG-1 reveals catalytic, step arrest, and joining-deficient mutants in the V(D)J recombinase.
Molecular and cellular biology 2002;22(10):3460-73.
2002: Thai To-Ha; Purugganan Mary M; Roth David B; Kearney John F
Distinct and opposite diversifying activities of terminal transferase splice variants.
Nature immunology 2002;3(5):457-62.
2002: Neiditch Matthew B; Lee Gregory S; Huye Leslie E; Brandt Vicky L; Roth David B
The V(D)J recombinase efficiently cleaves and transposes signal joints.
Molecular cell 2002;9(4):871-8.
2002: Lee Gregory S; Neiditch Matthew B; Sinden Richard R; Roth David B
Targeted transposition by the V(D)J recombinase.
Molecular and cellular biology 2002;22(7):2068-77.
2002: Brandt Vicky L; Roth David B
A recombinase diversified: new functions of the RAG proteins.
Current opinion in immunology 2002;14(2):224-9.
2001: Neiditch M B; Lee G S; Landree M A; Roth D B
RAG transposase can capture and commit to target DNA before or after donor cleavage.
Molecular and cellular biology 2001;21(13):4302-10.
2001: Landree M A; Kale S B; Roth D B
Functional organization of single and paired V(D)J cleavage complexes.
Molecular and cellular biology 2001;21(13):4256-64.
2001: Purugganan M M; Shah S; Kearney J F; Roth D B
Ku80 is required for addition of N nucleotides to V(D)J recombination junctions by terminal deoxynucleotidyl transferase.
Nucleic acids research 2001;29(7):1638-46.
2001: Qiu J X; Kale S B; Yarnell Schultz H; Roth D B
Separation-of-function mutants reveal critical roles for RAG2 in both the cleavage and joining steps of V(D)J recombination.
Molecular cell 2001;7(1):77-87.
2001: Yarnell Schultz H; Landree M A; Qiu J X; Kale S B; Roth D B
Joining-deficient RAG1 mutants block V(D)J recombination in vivo and hairpin opening in vitro.
Molecular cell 2001;7(1):65-75.
2001: Kale S B; Landree M A; Roth D B
Conditional RAG-1 mutants block the hairpin formation step of V(D)J recombination.
Molecular and cellular biology 2001;21(2):459-66.
2000: Huye L E; Roth D B
Differential requirements for cis and trans V(D)J cleavage: effects of substrate length.
Nucleic acids research 2000;28(24):4903-11.
2000: Roth D B; Roth S Y
Unequal access: regulating V(D)J recombination through chromatin remodeling.
Cell 2000;103(5):699-702.
2000: Roth D B; Gellert M
New guardians of the genome.
Nature 2000;404(6780):823-5.
2000: Roth D B
From lymphocytes to sharks: V(D)J recombinase moves to the germline.
Genome biology 2000;1(2):REVIEWS1014.
1999: Lin J M; Landree M A; Roth D B
V(D)J recombination catalyzed by mutant RAG proteins lacking consensus DNA-PK phosphorylation sites.
Molecular immunology 1999;36(18):1263-9.
1999: Landree M A; Wibbenmeyer J A; Roth D B
Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination.
Genes & development 1999;13(23):3059-69.
1999: Wang C; Bogue M A; Nguyen A P; Roth D B
Irradiation-induced rescue of thymocyte differentiation and V(D)J recombination in mice lacking the catalytic subunit of DNA-dependent protein kinase.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(11):6065-71.
1999: Wang C; Bogue M A; Levitt J M; Roth D B
Irradiation-mediated rescue of T cell-specific V(D)J recombination and thymocyte differentiation in severe combined immunodeficient mice by bone marrow cells.
The Journal of experimental medicine 1999;190(9):1257-62.
1999: Mickelsen S; Snyder C; Trujillo K; Bogue M; Roth D B; Meek K
Modulation of terminal deoxynucleotidyltransferase activity by the DNA-dependent protein kinase.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(2):834-43.
1999: Steen S B; Han J O; Mundy C; Oettinger M A; Roth D B
Roles of the "dispensable" portions of RAG-1 and RAG-2 in V(D)J recombination.
Molecular and cellular biology 1999;19(4):3010-7.
1999: Han J O; Steen S B; Roth D B
Intermolecular V(D)J recombination is prohibited specifically at the joining step.
Molecular cell 1999;3(3):331-8.
1999: Huye L E; Han J O; Roth D B
What prevents intermolecular V(D)J recombination?
Cold Spring Harbor symposia on quantitative biology 1999;64():191-5.
1998: Bogue M A; Jhappan C; Roth D B
Analysis of variable (diversity) joining recombination in DNAdependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK-independent pathways for both signal and coding joint formation.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(26):15559-64.
1998: Kabotyanski E B; Gomelsky L; Han J O; Stamato T D; Roth D B
Double-strand break repair in Ku86- and XRCC4-deficient cells.
Nucleic acids research 1998;26(23):5333-42.
1998: Roth D B; Craig N L
VDJ recombination: a transposase goes to work.
Cell 1998;94(4):411-4.
1998: Han J O; Erskine L A; Purugganan M M; Stamato T D; Roth D B
V(D)J recombination intermediates and non-standard products in XRCC4-deficient cells.
Nucleic acids research 1998;26(16):3769-75.
1997: Gu Y; Seidl K J; Rathbun G A; Zhu C; Manis J P; van der Stoep N; Davidson L; Cheng H L; Sekiguchi J M; Frank K; Stanhope-Baker P; Schlissel M S; Roth D B; Alt F W
Growth retardation and leaky SCID phenotype of Ku70-deficient mice.
Immunity 1997;7(5):653-65.
1997: Bogue M A; Wang C; Zhu C; Roth D B
V(D)J recombination in Ku86-deficient mice: distinct effects on coding, signal, and hybrid joint formation.
Immunity 1997;7(1):37-47.
1997: Wang C; Bogue M A; Roth D B; Meek K
Normal junctional diversification of immune receptors in p53-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(2):757-62.
1997: Steen S B; Gomelsky L; Speidel S L; Roth D B
Initiation of V(D)J recombination in vivo: role of recombination signal sequences in formation of single and paired double-strand breaks.
The EMBO journal 1997;16(10):2656-64.
1997: Han J O; Steen S B; Roth D B
Ku86 is not required for protection of signal ends or for formation of nonstandard V(D)J recombination products.
Molecular and cellular biology 1997;17(4):2226-34.
1996: Zhu C; Bogue M A; Roth D B
Thymocyte differentiation in gamma-irradiated severe-combined immunodeficient mice: characterization of intermediates and products of V(D)J recombination at the T cell receptor alpha locus.
European journal of immunology 1996;26(12):2859-65.
1996: Zhu C; Bogue M A; Lim D S; Hasty P; Roth D B
Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates.
Cell 1996;86(3):379-89.
1996: Steen S B; Gomelsky L; Roth D B
The 12/23 rule is enforced at the cleavage step of V(D)J recombination in vivo.
Genes to cells : devoted to molecular & cellular mechanisms 1996;1(6):543-53.
1996: Bogue M; Roth D B
Mechanism of V(D)J recombination.
Current opinion in immunology 1996;8(2):175-80.
1996: Bogue M A; Zhu C; Aguilar-Cordova E; Donehower L A; Roth D B
p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes.
Genes & development 1996;10(5):553-65.
1996: Merrihew R V; Marburger K; Pennington S L; Roth D B; Wilson J H
High-frequency illegitimate integration of transfected DNA at preintegrated target sites in a mammalian genome.
Molecular and cellular biology 1996;16(1):10-8.
1996: Zhu C; Roth D B
Mechanism of V(D)J recombination.
Cancer surveys 1996;28():295-309.
1996: Steen S B; Zhu C; Roth D B
Double-strand breaks, DNA hairpins, and the mechanism of V(D)J recombination.
Current topics in microbiology and immunology 1996;217():61-77.
1995: Nakajima P B; Menetski J P; Roth D B; Gellert M; Bosma M J
V-D-J rearrangements at the T cell receptor delta locus in mouse thymocytes of the alpha beta lineage.
Immunity 1995;3(5):609-21.
1995: Kabotyanski E B; Zhu C; Kallick D A; Roth D B
Hairpin opening by single-strand-specific nucleases.
Nucleic acids research 1995;23(19):3872-81.
1995: Roth D B; Lindahl T; Gellert M
Repair and recombination. How to make ends meet.
Current biology : CB 1995;5(5):496-9.
1995: Zhu C; Roth D B
Characterization of coding ends in thymocytes of scid mice: implications for the mechanism of V(D)J recombination.
Immunity 1995;2(1):101-12.
1993: Roth D B; Zhu C; Gellert M
Characterization of broken DNA molecules associated with V(D)J recombination.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(22):10788-92.
1992: Roth D B; Menetski J P; Nakajima P B; Bosma M J; Gellert M
V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes.
Cell 1992;70(6):983-91.
1992: Roth D B; Nakajima P B; Menetski J P; Bosma M J; Gellert M
V(D)J recombination in mouse thymocytes: double-strand breaks near T cell receptor delta rearrangement signals.
Cell 1992;69(1):41-53.
1992: Roth D B; Nakajima P B; Menetski J P; Bosma M J; Gellert M
Double-strand breaks associated with V(D)J recombination at the TCR delta locus in murine thymocytes.
Current topics in microbiology and immunology 1992;182():115-24.
1991: Roth D B; Proctor G N; Stewart L K; Wilson J H
Oligonucleotide capture during end joining in mammalian cells.
Nucleic acids research 1991;19(25):7201-5.
1989: Roth D B; Chang X B; Wilson J H
Comparison of filler DNA at immune, nonimmune, and oncogenic rearrangements suggests multiple mechanisms of formation.
Molecular and cellular biology 1989;9(7):3049-57.
1986: Roth D B; Wilson J H
Nonhomologous recombination in mammalian cells: role for short sequence homologies in the joining reaction.
Molecular and cellular biology 1986;6(12):4295-304.
1985: Roth D B; Porter T N; Wilson J H
Mechanisms of nonhomologous recombination in mammalian cells.
Molecular and cellular biology 1985;5(10):2599-607.
1985: Yeung C Y; Ingolia D E; Roth D B; Shoemaker C; Al-Ubaidi M R; Yen J Y; Ching C; Bobonis C; Kaufman R J; Kellems R E
Identification of functional murine adenosine deaminase cDNA clones by complementation in Escherichia coli.
The Journal of biological chemistry 1985;260(18):10299-307.
1985: Roth D B; Wilson J H
Relative rates of homologous and nonhomologous recombination in transfected DNA.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(10):3355-9.

Sign-in to see more