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John Roth

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Semarhy Quiñones-Soto; Andrew B Reams; John R Roth
Pathways of genetic adaptation: multistep origin of mutants under selection without induced mutagenesis in Salmonella enterica.
Joakim Näsvall; John R Roth; Lei Sun; Dan I Andersson
Real-time evolution of new genes by innovation, amplification, and divergence.
Andrew B Reams; Eric Kofoid; Elisabeth Kugelberg; John R Roth
Multiple pathways of duplication formation with and without recombination (RecA) in Salmonella enterica.

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All Publications

2012: Semarhy Quiñones-Soto; Andrew B Reams; John R Roth
Pathways of genetic adaptation: multistep origin of mutants under selection without induced mutagenesis in Salmonella enterica.
Genetics 2012;192(3):987-99.
2012: Joakim Näsvall; John R Roth; Lei Sun; Dan I Andersson
Real-time evolution of new genes by innovation, amplification, and divergence.
Science (New York, N.Y.) 2012;338(6105):384-7.
2012: Andrew B Reams; Eric Kofoid; Elisabeth Kugelberg; John R Roth
Multiple pathways of duplication formation with and without recombination (RecA) in Salmonella enterica.
Genetics 2012;192(2):397-415.
2012: John R Roth; D I Andersson
Poxvirus use a "gene accordion" to tune out host defenses.
Cell 2012;150(4):671-2.
2011: Parameth Thiennimitr; Vladimir Tolstikov; Renée M Tsolis; Maria G Winter; Sebastian E Winter; Mariana N Xavier; Douglas L Huseby; John R Roth; Torsten Sterzenbach; Andreas J Baumler
Intestinal inflammation allows Salmonella to use ethanolamine to compete with the microbiota.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(42):17480-5.
2011: Semarhy Quiñones-Soto; John R Roth
Effect of growth under selection on appearance of chromosomal mutations in Salmonella enterica.
Genetics 2011;189(1):37-53.
2011: John R Roth
The joys and terrors of fast adaptation: new findings elucidate antibiotic resistance and natural selection.
Molecular microbiology 2011;79(2):279-82.
2010: Sebastian E Winter; Parameth Thiennimitr; Maria G Winter; Brian P Butler; Douglas L Huseby; Robert W Crawford; Joseph Russell; Charles L Bevins; Garry Adams; Renée M Tsolis; John R Roth; Andreas J Baumler
Gut inflammation provides a respiratory electron acceptor for Salmonella.
Nature 2010;467(7314):426-9.
2010: Andrew B Reams; Eric Kofoid; Michael Savageau; John R Roth
Duplication frequency in a population of Salmonella enterica rapidly approaches steady state with or without recombination.
Genetics 2010;184(4):1077-94.
2010: John R Roth
Genetic adaptation: a new piece for a very old puzzle.
Current biology : CB 2010;20(1):R15-7.
2009: Song Sun; Otto G Berg; John R Roth; Dan I Andersson
Contribution of gene amplification to evolution of increased antibiotic resistance in Salmonella typhimurium.
Genetics 2009;182(4):1183-95.
2008: Marie Wrande; John R Roth; Diarmaid Hughes
Accumulation of mutants in "aging" bacterial colonies is due to growth under selection, not stress-induced mutagenesis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(33):11863-8.
2008: Peter J Anderson; Jozsef Lango; Colleen Carkeet; Audrey Britten; Bernhard Kräutler; Bruce D Hammock; John R Roth
One pathway can incorporate either adenine or dimethylbenzimidazole as an alpha-axial ligand of B12 cofactors in Salmonella enterica.
Journal of bacteriology 2008;190(4):1160-71.
2007: Ulfar Bergthorsson; Dan I Andersson; John R Roth
Ohno's dilemma: evolution of new genes under continuous selection.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(43):17004-9.
2006: Elisabeth Kugelberg; Eric Kofoid; Andrew B Reams; Dan I Andersson; John R Roth
Multiple pathways of selected gene amplification during adaptive mutation.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(46):17319-24.
2006: Julianne H Grose; Lisa Joss; Sidney F Velick; John R Roth
Evidence that feedback inhibition of NAD kinase controls responses to oxidative stress.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(20):7601-6.
2006: Colleen Carkeet; Stephen R Dueker; Jozsef Lango; Bruce Buchholz; Joshua Miller; Ralph Green; Bruce D Hammock; John R Roth; Peter J Anderson
Human vitamin B12 absorption measurement by accelerator mass spectrometry using specifically labeled (14)C-cobalamin.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(15):5694-9.
2006: Joseph T Penrod; John R Roth
Conserving a volatile metabolite: a role for carboxysome-like organelles in Salmonella enterica.
Journal of bacteriology 2006;188(8):2865-74.
2006: Rita M Cornish; John R Roth; C Dale Poulter
Lethal mutations in the isoprenoid pathway of Salmonella enterica.
Journal of bacteriology 2006;188(4):1444-50.
2006: John R Roth; Elisabeth Kugelberg; Andrew B Reams; Eric Kofoid; Dan I Andersson
Origin of mutations under selection: the adaptive mutation controversy.
Annual review of microbiology 2006;60():477-501.
2005: Sophie Maisnier-Patin; John R Roth; Asa Fredriksson; Thomas Nyström; Otto G Berg; Dan I Andersson
Genomic buffering mitigates the effects of deleterious mutations in bacteria.
Nature genetics 2005;37(12):1376-9.
2005: Julianne H Grose; Ulfar Bergthorsson; Yaping Xu; Jared Sterneckert; Behzad Khodaverdian; John R Roth
Assimilation of nicotinamide mononucleotide requires periplasmic AphA phosphatase in Salmonella enterica.
Journal of bacteriology 2005;187(13):4521-30.
2005: Marian Price-Carter; Thomas G Fazzio; Ester Ibañez Vallbona; John R Roth
Polyphosphate kinase protects Salmonella enterica from weak organic acid stress.
Journal of bacteriology 2005;187(9):3088-99.
2005: Julianne H Grose; Ulfar Bergthorsson; John R Roth
Regulation of NAD synthesis by the trifunctional NadR protein of Salmonella enterica.
Journal of bacteriology 2005;187(8):2774-82.
2005: Mats E Pettersson; Dan I Andersson; John R Roth; Otto G Berg
The amplification model for adaptive mutation: simulations and analysis.
Genetics 2005;169(2):1105-15.
2005: Ulfar Bergthorsson; John R Roth
Natural isolates of Salmonella enterica serovar Dublin carry a single nadA missense mutation.
Journal of bacteriology 2005;187(1):400-3.
2004: David E Sheppard; Joseph T Penrod; Thomas A Bobik; Eric Kofoid; John R Roth
Evidence that a B12-adenosyl transferase is encoded within the ethanolamine operon of Salmonella enterica.
Journal of bacteriology 2004;186(22):7635-44.
2004: Joseph T Penrod; Christopher C Mace; John R Roth
A pH-sensitive function and phenotype: evidence that EutH facilitates diffusion of uncharged ethanolamine in Salmonella enterica.
Journal of bacteriology 2004;186(20):6885-90.
2004: John R Roth; Dan I Andersson
Adaptive mutation: how growth under selection stimulates Lac(+) reversion by increasing target copy number.
Journal of bacteriology 2004;186(15):4855-60.
2004: John R Roth; Dan I Andersson
Rebuttal: adaptive mutation in Escherichia coli (Foster).
Journal of bacteriology 2004;186(15):4854.
2004: John R Roth; Dan I Andersson
Rebuttal: adaptive point mutation (Rosenberg and Hastings).
Journal of bacteriology 2004;186(15):4844.
2004: John R Roth; Dan I Andersson
Amplification-mutagenesis--how growth under selection contributes to the origin of genetic diversity and explains the phenomenon of adaptive mutation.
Research in microbiology 2004;155(5):342-51.
2003: Susan Slechta; Kim L Bunny; Elisabeth Kugelberg; Eric Kofoid; Dan I Andersson; John R Roth
Adaptive mutation: general mutagenesis is not a programmed response to stress but results from rare coamplification of dinB with lac.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(22):12847-52.
2003: John R Roth; Eric Kofoid; Frederick P Roth; Otto G Berg; Jon Seger; Dan I Andersson
Regulating general mutation rates: examination of the hypermutable state model for Cairnsian adaptive mutation.
Genetics 2003;163(4):1483-96.
2003: Eric Kofoid; Ulfar Bergthorsson; Susan Slechta; John R Roth
Formation of an F' plasmid by recombination between imperfectly repeated chromosomal Rep sequences: a closer look at an old friend (F'(128) pro lac).
Journal of bacteriology 2003;185(2):660-3.
2002: Susan Slechta; Jing Liu; Dan I Andersson; John R Roth
Evidence that selected amplification of a bacterial lac frameshift allele stimulates Lac(+) reversion (adaptive mutation) with or without general hypermutability.
Genetics 2002;161(3):945-56.
2002: Susan Slechta; Jennifer Harold; Dan I Andersson; John R Roth
The effect of genomic position on reversion of a lac frameshift mutation (lacIZ33) during non-lethal selection (adaptive mutation).
Molecular microbiology 2002;44(4):1017-32.
2002: Heather Hendrickson; Susan Slechta; Ulfar Bergthorsson; Dan I Andersson; John R Roth
Amplification-mutagenesis: evidence that "directed" adaptive mutation and general hypermutability result from growth with a selected gene amplification.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(4):2164-9.
2002: Richard Ellis Hudson; Ulfar Bergthorsson; John R Roth; Howard Ochman
Effect of chromosome location on bacterial mutation rates.
Molecular biology and evolution 2002;19(1):85-92.
2001: Marian Price-Carter; J Tingey; Thomas A Bobik; John R Roth
The alternative electron acceptor tetrathionate supports B12-dependent anaerobic growth of Salmonella enterica serovar typhimurium on ethanolamine or 1,2-propanediol.
Journal of bacteriology 2001;183(8):2463-75.
1999: M Van Bibber; C Bradbeer; N Clark; John R Roth
A new class of cobalamin transport mutants (btuF) provides genetic evidence for a periplasmic binding protein in Salmonella typhimurium.
Journal of bacteriology 1999;181(17):5539-41.
1998: Dan I Andersson; Susan Slechta; John R Roth
Evidence that gene amplification underlies adaptive mutability of the bacterial lac operon.
Science (New York, N.Y.) 1998;282(5391):1133-5.
1997: Thomas A Bobik; Y Xu; R M Jeter; K E Otto; John R Roth
Propanediol utilization genes (pdu) of Salmonella typhimurium: three genes for the propanediol dehydratase.
Journal of bacteriology 1997;179(21):6633-9.
1997: Michael Ailion; John R Roth
Repression of the cob operon of Salmonella typhimurium by adenosylcobalamin is influenced by mutations in the pdu operon.
Journal of bacteriology 1997;179(19):6084-91.
1997: CA Rappleye; John R Roth
A Tn10 derivative (T-POP) for isolation of insertions with conditional (tetracycline-dependent) phenotypes.
Journal of bacteriology 1997;179(18):5827-34.
1997: T Galitski; John R Roth
Pathways for homologous recombination between chromosomal direct repeats in Salmonella typhimurium.
Genetics 1997;146(3):751-67.
1997: CA Rappleye; John R Roth
Transposition without transposase: a spontaneous mutation in bacteria.
Journal of bacteriology 1997;179(6):2047-52.
1996: T G Fazzio; John R Roth
Evidence that the CysG protein catalyzes the first reaction specific to B12 synthesis in Salmonella typhimurium, insertion of cobalt.
Journal of bacteriology 1996;178(23):6952-9.
1996: Jeffrey G Lawrence; John R Roth
Selfish operons: horizontal transfer may drive the evolution of gene clusters.
Genetics 1996;143(4):1843-60.
1996: T Galitski; John R Roth
A search for a general phenomenon of adaptive mutability.
Genetics 1996;143(2):645-59.
1996: L Miesel; John R Roth
Evidence that SbcB and RecF pathway functions contribute to RecBCD-dependent transductional recombination.
Journal of bacteriology 1996;178(11):3146-55.
1996: John R Roth; Jeffrey G Lawrence; Thomas A Bobik
Cobalamin (coenzyme B12): synthesis and biological significance.
Annual review of microbiology 1996;50():137-81.
1996: Jeffrey G Lawrence; John R Roth
Evolution of coenzyme B12 synthesis among enteric bacteria: evidence for loss and reacquisition of a multigene complex.
Genetics 1996;142(1):11-24.
1995: K R Haack; John R Roth
Recombination between chromosomal IS200 elements supports frequent duplication formation in Salmonella typhimurium.
Genetics 1995;141(4):1245-52.
1995: Jeffrey G Lawrence; John R Roth
The cobalamin (coenzyme B12) biosynthetic genes of Escherichia coli.
Journal of bacteriology 1995;177(22):6371-80.
1995: T Galitski; John R Roth
Evidence that F plasmid transfer replication underlies apparent adaptive mutation.
Science (New York, N.Y.) 1995;268(5209):421-3.
1994: P Chen; D I Andersson; John R Roth
The control region of the pdu/cob regulon in Salmonella typhimurium.
Journal of bacteriology 1994;176(17):5474-82.
1994: L Miesel; A Segall; John R Roth
Construction of chromosomal rearrangements in Salmonella by transduction: inversions of non-permissive segments are not lethal.
Genetics 1994;137(4):919-32.
1994: W Cheng; John R Roth
Evidence for two NAD kinases in Salmonella typhimurium.
Journal of bacteriology 1994;176(14):4260-8.
1994: L Miesel; John R Roth
Salmonella recD mutations increase recombination in a short sequence transduction assay.
Journal of bacteriology 1994;176(13):4092-103.
1994: A M Segall; John R Roth
Approaches to half-tetrad analysis in bacteria: recombination between repeated, inverse-order chromosomal sequences.
Genetics 1994;136(1):27-39.
1993: Michael Ailion; Thomas A Bobik; John R Roth
Two global regulatory systems (Crp and Arc) control the cobalamin/propanediol regulon of Salmonella typhimurium.
Journal of bacteriology 1993;175(22):7200-8.
1993: John R Roth; Jeffrey G Lawrence; M Rubenfield; S Kieffer-Higgins; G M Church
Characterization of the cobalamin (vitamin B12) biosynthetic genes of Salmonella typhimurium.
Journal of bacteriology 1993;175(11):3303-16.
1993: Barry Goldman; John R Roth
Genetic structure and regulation of the cysG gene in Salmonella typhimurium.
Journal of bacteriology 1993;175(5):1457-66.
1993: R V Sonti; D H Keating; John R Roth
Lethal transposition of Mud phages in Rec- strains of Salmonella typhimurium.
Genetics 1993;133(1):17-28.
1992: D M Roof; John R Roth
Autogenous regulation of ethanolamine utilization by a transcriptional activator of the eut operon in Salmonella typhimurium.
Journal of bacteriology 1992;174(20):6634-43.
1992: M J Mahan; J Casadesus; John R Roth
The Salmonella typhimurium RecJ function permits growth of P22 abc phage on recBCD+ hosts.
Molecular & general genetics : MGG 1992;232(3):470-8.
1992: C Grabau; John R Roth
A Salmonella typhimurium cobalamin-deficient mutant blocked in 1-amino-2-propanol synthesis.
Journal of bacteriology 1992;174(7):2138-44.
1992: Thomas A Bobik; Michael Ailion; John R Roth
A single regulatory gene integrates control of vitamin B12 synthesis and propanediol degradation.
Journal of bacteriology 1992;174(7):2253-66.
1991: M J Mahan; John R Roth
Ability of a bacterial chromosome segment to invert is dictated by included material rather than flanking sequence.
Genetics 1991;129(4):1021-32.
1991: Diana Marie Downs; John R Roth
Synthesis of thiamine in Salmonella typhimurium independent of the purF function.
Journal of bacteriology 1991;173(20):6597-604.
1991: N Zhu; Baldomero M Olivera; John R Roth
Activity of the nicotinamide mononucleotide transport system is regulated in Salmonella typhimurium.
Journal of bacteriology 1991;173(3):1311-20.
1991: N Zhu; John R Roth
The nadI region of Salmonella typhimurium encodes a bifunctional regulatory protein.
Journal of bacteriology 1991;173(3):1302-10.
1989: D I Andersson; John R Roth
Redox regulation of the genes for cobinamide biosynthesis in Salmonella typhimurium.
Journal of bacteriology 1989;171(12):6734-9.
1989: D I Andersson; John R Roth
Mutations affecting regulation of cobinamide biosynthesis in Salmonella typhimurium.
Journal of bacteriology 1989;171(12):6726-33.
1989: R V Sonti; John R Roth
Role of gene duplications in the adaptation of Salmonella typhimurium to growth on limiting carbon sources.
Genetics 1989;123(1):19-28.
1989: A M Segall; John R Roth
Recombination between homologies in direct and inverse orientation in the chromosome of Salmonella: intervals which are nonpermissive for inversion formation.
Genetics 1989;122(4):737-47.
1989: N Zhu; Baldomero M Olivera; John R Roth
Genetic characterization of the pnuC gene, which encodes a component of the nicotinamide mononucleotide transport system in Salmonella typhimurium.
Journal of bacteriology 1989;171(8):4402-9.
1989: D M Roof; John R Roth
Functions required for vitamin B12-dependent ethanolamine utilization in Salmonella typhimurium.
Journal of bacteriology 1989;171(6):3316-23.
1989: T Elliott; John R Roth
Heme-deficient mutants of Salmonella typhimurium: two genes required for ALA synthesis.
Molecular & general genetics : MGG 1989;216(2-3):303-14.
1989: U E Park; Baldomero M Olivera; K T Hughes; John R Roth; David R Hillyard
DNA ligase and the pyridine nucleotide cycle in Salmonella typhimurium.
Journal of bacteriology 1989;171(4):2173-80.
1989: J Casadesus; John R Roth
Absence of insertions among spontaneous mutants of Salmonella typhimurium.
Molecular & general genetics : MGG 1989;216(2-3):210-6.
1989: J Casadesus; John R Roth
Transcriptional occlusion of transposon targets.
Molecular & general genetics : MGG 1989;216(2-3):204-9.
1989: M J Mahan; John R Roth
Role of recBC function in formation of chromosomal rearrangements: a two-step model for recombination.
Genetics 1989;121(3):433-43.
1989: M J Mahan; John R Roth
recB and recC genes of Salmonella typhimurium.
Journal of bacteriology 1989;171(1):612-5.
1988: A Wang; John R Roth
Activation of silent genes by transposons Tn5 and Tn10.
Genetics 1988;120(4):875-85.
1988: A Segall; M J Mahan; John R Roth
Rearrangement of the bacterial chromosome: forbidden inversions.
Science (New York, N.Y.) 1988;241(4871):1314-8.
1988: M J Mahan; John R Roth
Reciprocality of recombination events that rearrange the chromosome.
Genetics 1988;120(1):23-35.
1988: D M Roof; John R Roth
Ethanolamine utilization in Salmonella typhimurium.
Journal of bacteriology 1988;170(9):3855-63.
1988: T Elliott; John R Roth
Characterization of Tn10d-Cam: a transposition-defective Tn10 specifying chloramphenicol resistance.
Molecular & general genetics : MGG 1988;213(2-3):332-8.
1988: U E Park; John R Roth; Baldomero M Olivera
Salmonella typhimurium mutants lacking NAD pyrophosphatase.
Journal of bacteriology 1988;170(8):3725-30.
1988: K T Hughes; John R Roth
Transitory cis complementation: a method for providing transposition functions to defective transposons.
Genetics 1988;119(1):9-12.
1988: K T Hughes; Baldomero M Olivera; John R Roth
Structural gene for NAD synthetase in Salmonella typhimurium.
Journal of bacteriology 1988;170(5):2113-20.
1988: M S Ciampi; John R Roth
Polarity effects in the hisG gene of salmonella require a site within the coding sequence.
Genetics 1988;118(2):193-202.
1988: N Zhu; Baldomero M Olivera; John R Roth
Identification of a repressor gene involved in the regulation of NAD de novo biosynthesis in Salmonella typhimurium.
Journal of bacteriology 1988;170(1):117-25.
1987: Diana Marie Downs; John R Roth
A novel P22 prophage in Salmonella typhimurium.
Genetics 1987;117(3):367-80.
1987: R M Jeter; John R Roth
Cobalamin (vitamin B12) biosynthetic genes of Salmonella typhimurium.
Journal of bacteriology 1987;169(7):3189-98.
1984: R M Jeter; B M Olivera; John R Roth
Salmonella typhimurium synthesizes cobalamin (vitamin B12) de novo under anaerobic growth conditions.
Journal of bacteriology 1984;159(1):206-13.
1980: M Schmid; John R Roth
Circularization of transduced fragments: a mechanism for adding segments to the bacterial chromosome.
Genetics 1980;94(1):15-29.
1979: F G Chumley; R Menzel; John R Roth
Hfr formation directed by tn10.
Genetics 1979;91(4):639-55.