Robert Roth

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Zou Wei; Beggs Kevin M; Sparkenbaugh Erica M; Jones A Daniel; Younis Husam S; Roth Robert A; Ganey Patricia E
Sulindac metabolism and synergy with tumor necrosis factor-alpha in a drug-inflammation interaction model of idiosyncratic liver injury.
Shaw Patrick J; Beggs Kevin M; Sparkenbaugh Erica M; Dugan Christine M; Ganey Patricia E; Roth Robert A
Trovafloxacin enhances TNF-induced inflammatory stress and cell death signaling and reduces TNF clearance in a murine model of idiosyncratic hepatotoxicity.
Deng Xiaomin; Luyendyk James P; Ganey Patricia E; Roth Robert A
Inflammatory stress and idiosyncratic hepatotoxicity: hints from animal models.

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All Publications

2009: Zou Wei; Beggs Kevin M; Sparkenbaugh Erica M; Jones A Daniel; Younis Husam S; Roth Robert A; Ganey Patricia E
Sulindac metabolism and synergy with tumor necrosis factor-alpha in a drug-inflammation interaction model of idiosyncratic liver injury.
The Journal of pharmacology and experimental therapeutics 2009;331(1):114-21.
2009: Shaw Patrick J; Beggs Kevin M; Sparkenbaugh Erica M; Dugan Christine M; Ganey Patricia E; Roth Robert A
Trovafloxacin enhances TNF-induced inflammatory stress and cell death signaling and reduces TNF clearance in a murine model of idiosyncratic hepatotoxicity.
Toxicological sciences : an official journal of the Society of Toxicology 2009;111(2):288-301.
2009: Deng Xiaomin; Luyendyk James P; Ganey Patricia E; Roth Robert A
Inflammatory stress and idiosyncratic hepatotoxicity: hints from animal models.
Pharmacological reviews 2009;61(3):262-82.
2009: Shaw Patrick J; Ganey Patricia E; Roth Robert A
Trovafloxacin enhances the inflammatory response to a Gram-negative or a Gram-positive bacterial stimulus, resulting in neutrophil-dependent liver injury in mice.
The Journal of pharmacology and experimental therapeutics 2009;330(1):72-8.
2009: Zou Wei; Devi Sachin S; Sparkenbaugh Erica; Younis Husam S; Roth Robert A; Ganey Patricia E
Hepatotoxic interaction of sulindac with lipopolysaccharide: role of the hemostatic system.
Toxicological sciences : an official journal of the Society of Toxicology 2009;108(1):184-93.
2008: Deng Xiaomin; Liguori Michael J; Sparkenbaugh Erica M; Waring Jeffrey F; Blomme Eric A G; Ganey Patricia E; Roth Robert A
Gene expression profiles in livers from diclofenac-treated rats reveal intestinal bacteria-dependent and -independent pathways associated with liver injury.
The Journal of pharmacology and experimental therapeutics 2008;327(3):634-44.
2008: Deng Xiaomin; Lu Jingtao; Lehman-McKeeman Lois D; Malle Ernst; Crandall David L; Ganey Patricia E; Roth Robert A
p38 mitogen-activated protein kinase-dependent tumor necrosis factor-alpha-converting enzyme is important for liver injury in hepatotoxic interaction between lipopolysaccharide and ranitidine.
The Journal of pharmacology and experimental therapeutics 2008;326(1):144-52.
2007: Shaw Patrick J; Hopfensperger Marie J; Ganey Patricia E; Roth Robert A
Lipopolysaccharide and trovafloxacin coexposure in mice causes idiosyncrasy-like liver injury dependent on tumor necrosis factor-alpha.
Toxicological sciences : an official journal of the Society of Toxicology 2007;100(1):259-66.
2007: Tukov Francis F; Luyendyk James P; Ganey Patricia E; Roth Robert A
The role of tumor necrosis factor alpha in lipopolysaccharide/ranitidine-induced inflammatory liver injury.
Toxicological sciences : an official journal of the Society of Toxicology 2007;100(1):267-80.
2007: Ganey Patricia E; Luyendyk James P; Newport Sandra W; Eagle Theresa M; Maddox Jane F; Mackman Nigel; Roth Robert A
Role of the coagulation system in acetaminophen-induced hepatotoxicity in mice.
Hepatology (Baltimore, Md.) 2007;46(4):1177-86.
2007: Deng Xiaomin; Luyendyk James P; Zou Wei; Lu Jingtao; Malle Ernst; Ganey Patricia E; Roth Robert A
Neutrophil interaction with the hemostatic system contributes to liver injury in rats cotreated with lipopolysaccharide and ranitidine.
The Journal of pharmacology and experimental therapeutics 2007;322(2):852-61.
2007: Bezdecny Steven A; Karmaus Peer; Roth Robert A; Ganey Patricia E
2,2',4,4'-Tetrachlorobiphenyl upregulates cyclooxygenase-2 in HL-60 cells via p38 mitogen-activated protein kinase and NF-kappaB.
Toxicology and applied pharmacology 2007;221(3):285-94.
2007: Lee KangAe; Roth Robert A; LaPres John J
Hypoxia, drug therapy and toxicity.
Pharmacology & therapeutics 2007;113(2):229-46.
2006: Deng Xiaomin; Stachlewitz Robert F; Liguori Michael J; Blomme Eric A G; Waring Jeffrey F; Luyendyk James P; Maddox Jane F; Ganey Patricia E; Roth Robert A
Modest inflammation enhances diclofenac hepatotoxicity in rats: role of neutrophils and bacterial translocation.
The Journal of pharmacology and experimental therapeutics 2006;319(3):1191-9.
2006: Tukov Francis F; Maddox Jane F; Amacher David E; Bobrowski Walter F; Roth Robert A; Ganey Patricia E
Modeling inflammation-drug interactions in vitro: a rat Kupffer cell-hepatocyte coculture system.
Toxicology in vitro : an international journal published in association with BIBRA 2006;20(8):1488-99.
2006: Copple Bryan L; Roth Robert A; Ganey Patricia E
Anticoagulation and inhibition of nitric oxide synthase influence hepatic hypoxia after monocrotaline exposure.
Toxicology 2006;225(2-3):128-37.
2006: Bergheim Ina; Guo Luping; Davis Molly Anne; Lambert Jason C; Beier Juliane I; Duveau Ilinca; Luyendyk James P; Roth Robert A; Arteel Gavin E
Metformin prevents alcohol-induced liver injury in the mouse: Critical role of plasminogen activator inhibitor-1.
Gastroenterology 2006;130(7):2099-112.
2006: Luyendyk James P; Lehman-McKeeman Lois D; Nelson David M; Bhaskaran Vasanthi M; Reilly Timothy P; Car Bruce D; Cantor Glenn H; Deng Xiaomin; Maddox Jane F; Ganey Patricia E; Roth Robert A
Coagulation-dependent gene expression and liver injury in rats given lipopolysaccharide with ranitidine but not with famotidine.
The Journal of pharmacology and experimental therapeutics 2006;317(2):635-43.
2006: Luyendyk James P; Lehman-McKeeman Lois D; Nelson David M; Bhaskaran Vasanthi M; Reilly Timothy P; Car Bruce D; Cantor Glenn H; Maddox Jane F; Ganey Patricia E; Roth Robert A
Unique gene expression and hepatocellular injury in the lipopolysaccharide-ranitidine drug idiosyncrasy rat model: comparison with famotidine.
Toxicological sciences : an official journal of the Society of Toxicology 2006;90(2):569-85.
2006: Maddox Jane F; Luyendyk James P; Cosma Gregory N; Breau Alan P; Bible Roy H; Harrigan George G; Goodacre Royston; Ganey Patricia E; Cantor Glenn H; Cockerell Gary L; Roth Robert A
Metabonomic evaluation of idiosyncrasy-like liver injury in rats cotreated with ranitidine and lipopolysaccharide.
Toxicology and applied pharmacology 2006;212(1):35-44.
2006: Bergheim Ina; Luyendyk James P; Steele Chad; Russell Gilandra K; Guo Luping; Roth Robert A; Arteel Gavin E
Metformin prevents endotoxin-induced liver injury after partial hepatectomy.
The Journal of pharmacology and experimental therapeutics 2006;316(3):1053-61.
2006: Waring Jeffrey F; Liguori Michael J; Luyendyk James P; Maddox Jane F; Ganey Patricia E; Stachlewitz Robert F; North Colin; Blomme Eric A G; Roth Robert A
Microarray analysis of lipopolysaccharide potentiation of trovafloxacin-induced liver injury in rats suggests a role for proinflammatory chemokines and neutrophils.
The Journal of pharmacology and experimental therapeutics 2006;316(3):1080-7.
2005: Luyendyk James P; Shaw Patrick J; Green Christopher D; Maddox Jane F; Ganey Patricia E; Roth Robert A
Coagulation-mediated hypoxia and neutrophil-dependent hepatic injury in rats given lipopolysaccharide and ranitidine.
The Journal of pharmacology and experimental therapeutics 2005;314(3):1023-31.
2005: Bezdecny Steven A; Roth Robert A; Ganey Patricia E
Effects of 2,2',4,4'-tetrachlorobiphenyl on granulocytic HL-60 cell function and expression of cyclooxygenase-2.
Toxicological sciences : an official journal of the Society of Toxicology 2005;84(2):328-34.
2004: Luyendyk James P; Maddox Jane F; Green Christopher D; Ganey Patricia E; Roth Robert A
Role of hepatic fibrin in idiosyncrasy-like liver injury from lipopolysaccharide-ranitidine coexposure in rats.
Hepatology (Baltimore, Md.) 2004;40(6):1342-51.
2004: Ganey Patricia E; Luyendyk James P; Maddox Jane F; Roth Robert A
Adverse hepatic drug reactions: inflammatory episodes as consequence and contributor.
Chemico-biological interactions 2004;150(1):35-51.
2004: Luyendyk James P; Mattes William B; Burgoon Lyle D; Zacharewski Timothy R; Maddox Jane F; Cosma Gregory N; Ganey Patricia E; Roth Robert A
Gene expression analysis points to hemostasis in livers of rats cotreated with lipopolysaccharide and ranitidine.
Toxicological sciences : an official journal of the Society of Toxicology 2004;80(1):203-13.
2004: Harrigan George G; LaPlante Roxanne H; Cosma Greg N; Cockerell Gary; Goodacre Royston; Maddox Jane F; Luyendyk James P; Ganey Patricia E; Roth Robert A
Application of high-throughput Fourier-transform infrared spectroscopy in toxicology studies: contribution to a study on the development of an animal model for idiosyncratic toxicity.
Toxicology letters 2004;146(3):197-205.
2004: Maddox Jane F; Domzalski Alison C; Roth Robert A; Ganey Patricia E
15-deoxy prostaglandin J2 enhances allyl alcohol-induced toxicity in rat hepatocytes.
Toxicological sciences : an official journal of the Society of Toxicology 2004;77(2):290-8.
2004: Copple Bryan L; Rondelli Catherine M; Maddox Jane F; Hoglen Niel C; Ganey Patricia E; Roth Robert A
Modes of cell death in rat liver after monocrotaline exposure.
Toxicological sciences : an official journal of the Society of Toxicology 2004;77(1):172-82.
2003: Hanumegowda Umesh M; Copple Bryan L; Shibuya Masabumi; Malle Ernst; Ganey Patricia E; Roth Robert A
Basement membrane and matrix metalloproteinases in monocrotaline-induced liver injury.
Toxicological sciences : an official journal of the Society of Toxicology 2003;76(1):237-46.
2003: Roth Robert A; Luyendyk James P; Maddox Jane F; Ganey Patricia E
Inflammation and drug idiosyncrasy--is there a connection?
The Journal of pharmacology and experimental therapeutics 2003;307(1):1-8.
2003: Luyendyk James P; Maddox Jane F; Cosma Gregory N; Ganey Patricia E; Cockerell Gary L; Roth Robert A
Ranitidine treatment during a modest inflammatory response precipitates idiosyncrasy-like liver injury in rats.
The Journal of pharmacology and experimental therapeutics 2003;307(1):9-16.
2003: Copple Bryan L; Ganey Patricia E; Roth Robert A
Liver inflammation during monocrotaline hepatotoxicity.
Toxicology 2003;190(3):155-69.
2003: Yee Steven B; Harkema Jack R; Ganey Patricia E; Roth Robert A
The coagulation system contributes to synergistic liver injury from exposure to monocrotaline and bacterial lipopolysaccharide.
Toxicological sciences : an official journal of the Society of Toxicology 2003;74(2):457-69.
2003: Yee Steven B; Hanumegowda Umesh M; Copple Bryan L; Shibuya Masabumi; Ganey Patricia E; Roth Robert A
Endothelial cell injury and coagulation system activation during synergistic hepatotoxicity from monocrotaline and bacterial lipopolysaccharide coexposure.
Toxicological sciences : an official journal of the Society of Toxicology 2003;74(1):203-14.
2003: Maddox Jane F; Roth Robert A; Ganey Patricia E
Allyl alcohol activation of protein kinase C delta leads to cytotoxicity of rat hepatocytes.
Chemical research in toxicology 2003;16(5):609-15.
2003: Copple Bryan L; Moulin Frederic; Hanumegowda Umesh M; Ganey Patricia E; Roth Robert A
Thrombin and protease-activated receptor-1 agonists promote lipopolysaccharide-induced hepatocellular injury in perfused livers.
The Journal of pharmacology and experimental therapeutics 2003;305(2):417-25.
2003: Luyendyk James P; Copple Bryan L; Barton Charles C; Ganey Patricia E; Roth Robert A
Augmentation of aflatoxin B1 hepatotoxicity by endotoxin: involvement of endothelium and the coagulation system.
Toxicological sciences : an official journal of the Society of Toxicology 2003;72(1):171-81.
2003: Yee Steven B; Hanumegowda Umesh M; Hotchkiss Jon A; Ganey Patricia E; Roth Robert A
Role of neutrophils in the synergistic liver injury from monocrotaline and bacterial lipopolysaccharide exposure.
Toxicological sciences : an official journal of the Society of Toxicology 2003;72(1):43-56.
2003: Yee Steven B; Ganey Patricia E; Roth Robert A
The role of Kupffer cells and TNF-alpha in monocrotaline and bacterial lipopolysaccharide-induced liver injury.
Toxicological sciences : an official journal of the Society of Toxicology 2003;71(1):124-32.
2002: Kinser Shawn; Copple Bryan L; Roth Robert A; Ganey Patricia E
Enhancement of allyl alcohol hepatotoxicity by endotoxin requires extrahepatic factors.
Toxicological sciences : an official journal of the Society of Toxicology 2002;69(2):470-81.
2002: Yee Steven B; Copple Bryan L; Ganey Patricia E; Roth Robert A
The temporal relationship between bacterial lipopolysaccharide and monocrotaline exposures influences toxicity: shift in response from hepatotoxicity to nitric oxide-dependent lethality.
Journal of toxicology and environmental health. Part A 2002;65(14):961-76.
2002: Luyendyk James P; Shores Kate C; Ganey Patricia E; Roth Robert A
Bacterial lipopolysaccharide exposure alters aflatoxin B(1) hepatotoxicity: benchmark dose analysis for markers of liver injury.
Toxicological sciences : an official journal of the Society of Toxicology 2002;68(1):220-5.
2002: Copple Bryan L; Woolley Brook; Banes Amy; Ganey Patricia E; Roth Robert A
Anticoagulants prevent monocrotaline-induced hepatic parenchymal cell injury but not endothelial cell injury in the rat.
Toxicology and applied pharmacology 2002;180(3):186-96.
2002: Wagner James G; Harkema Jack R; Roth Robert A
Pulmonary leukostasis and the inhibition of airway neutrophil recruitment are early events in the endotoxemic rat.
Shock (Augusta, Ga.) 2002;17(2):151-8.
2002: Copple Bryan L; Banes Amy; Ganey Patricia E; Roth Robert A
Endothelial cell injury and fibrin deposition in rat liver after monocrotaline exposure.
Toxicological sciences : an official journal of the Society of Toxicology 2002;65(2):309-18.
2002: Buchweitz John P; Ganey Patricia E; Bursian Steven J; Roth Robert A
Underlying endotoxemia augments toxic responses to chlorpromazine: is there a relationship to drug idiosyncrasy?
The Journal of pharmacology and experimental therapeutics 2002;300(2):460-7.
2001: Ganey P E; Roth R A
Concurrent inflammation as a determinant of susceptibility to toxicity from xenobiotic agents.
Toxicology 2001;169(3):195-208.
2001: Moulin F; Copple B L; Ganey P E; Roth R A
Hepatic and extrahepatic factors critical for liver injury during lipopolysaccharide exposure.
American journal of physiology. Gastrointestinal and liver physiology 2001;281(6):G1423-31.
2001: Ganey P E; Barton Y W; Kinser S; Sneed R A; Barton C C; Roth R A
Involvement of cyclooxygenase-2 in the potentiation of allyl alcohol-induced liver injury by bacterial lipopolysaccharide.
Toxicology and applied pharmacology 2001;174(2):113-21.
2001: Barton C C; Barton E X; Ganey P E; Kunkel S L; Roth R A
Bacterial lipopolysaccharide enhances aflatoxin B1 hepatotoxicity in rats by a mechanism that depends on tumor necrosis factor alpha.
Hepatology (Baltimore, Md.) 2001;33(1):66-73.
2000: Barton C C; Ganey P E; Roth R A
Lipopolysaccharide augments aflatoxin B(1)-induced liver injury through neutrophil-dependent and -independent mechanisms.
Toxicological sciences : an official journal of the Society of Toxicology 2000;58(1):208-15.
2000: Rumbeiha W K; Fitzgerald S D; Braselton W E; Roth R A; Pestka J J; Kaneene J B
Augmentation of mercury-induced nephrotoxicity by endotoxin in the mouse.
Toxicology 2000;151(1-3):103-16.
2000: Wagner J G; Roth R A
Neutrophil migration mechanisms, with an emphasis on the pulmonary vasculature.
Pharmacological reviews 2000;52(3):349-74.
2000: Rumbeiha W K; Fitzgerald S D; Braselton W E; Roth R A; Kaneene J B
Potentiation of mercury-induced nephrotoxicity by endotoxin in the Sprague-Dawley rat.
Toxicology 2000;149(2-3):75-87.
2000: Yee S B; Kinser S; Hill D A; Barton C C; Hotchkiss J A; Harkema J R; Ganey P E; Roth R A
Synergistic hepatotoxicity from coexposure to bacterial endotoxin and the pyrrolizidine alkaloid monocrotaline.
Toxicology and applied pharmacology 2000;166(3):173-85.
2000: Barton C C; Hill D A; Yee S B; Barton E X; Ganey P E; Roth R A
Bacterial lipopolysaccharide exposure augments aflatoxin B(1)-induced liver injury.
Toxicological sciences : an official journal of the Society of Toxicology 2000;55(2):444-52.
2000: Zhou H R; Harkema J R; Hotchkiss J A; Yan D; Roth R A; Pestka J J
Lipopolysaccharide and the trichothecene vomitoxin (deoxynivalenol) synergistically induce apoptosis in murine lymphoid organs.
Toxicological sciences : an official journal of the Society of Toxicology 2000;53(2):253-63.
1999: Wagner J G; Roth R A
Neutrophil migration during endotoxemia.
Journal of leukocyte biology 1999;66(1):10-24.
1999: Wagner J G; Driscoll K E; Roth R A
Inhibition of pulmonary neutrophil trafficking during endotoxemia is dependent on the stimulus for migration.
American journal of respiratory cell and molecular biology 1999;20(4):769-76.
1999: Hill D A; Jean P A; Roth R A
Bile duct epithelial cells exposed to alpha-naphthylisothiocyanate produce a factor that causes neutrophil-dependent hepatocellular injury in vitro.
Toxicological sciences : an official journal of the Society of Toxicology 1999;47(1):118-25.
1998: Jean P A; Kessel S L; Hill D A; Roth R A
Cytotoxicity of naphthylisothiocyanates in rat hepatocyte-neutrophil cocultures.
Toxicology letters 1998;95(3):155-63.
1998: Lappin P B; Ross K L; King L E; Fraker P J; Roth R A
The response of pulmonary vascular endothelial cells to monocrotaline pyrrole: cell proliferation and DNA synthesis in vitro and in vivo.
Toxicology and applied pharmacology 1998;150(1):37-48.
1998: Hill D A; Roth R A
Alpha-naphthylisothiocyanate causes neutrophils to release factors that are cytotoxic to hepatocytes.
Toxicology and applied pharmacology 1998;148(1):169-75.
1997: Roth R A; Harkema J R; Pestka J P; Ganey P E
Is exposure to bacterial endotoxin a determinant of susceptibility to intoxication from xenobiotic agents?
Toxicology and applied pharmacology 1997;147(2):300-11.
1997: Pearson J M; Bailie M B; Fink G D; Roth R A
Neither platelet activating factor nor leukotrienes are critical mediators of liver injury after lipopolysaccharide administration.
Toxicology 1997;121(3):181-9.
1997: Lappin P B; Roth R A
Hypertrophy and prolonged DNA synthesis in smooth muscle cells characterize pulmonary arterial wall thickening after monocrotaline pyrrole administration to rats.
Toxicologic pathology 1997;25(4):372-80.
1997: Brown A P; Harkema J R; Schultze A E; Roth R A; Ganey P E
Gadolinium chloride pretreatment protects against hepatic injury but predisposes the lungs to alveolitis after lipopolysaccharide administration.
Shock (Augusta, Ga.) 1997;7(3):186-92.
1997: Roth R A; Dahm L J
Neutrophil- and glutathione-mediated hepatotoxicity of alpha-naphthylisothiocyanate.
Drug metabolism reviews 1997;29(1-2):153-65.
1996: Moulin F; Pearson J M; Schultze A E; Scott M A; Schwartz K A; Davis J M; Ganey P E; Roth R A
Thrombin is a distal mediator of lipopolysaccharide-induced liver injury in the rat.
The Journal of surgical research 1996;65(2):149-58.
1996: Pearson J M; Schultze A E; Schwartz K A; Scott M A; Davis J M; Roth R A
The thrombin inhibitor, hirudin, attenuates lipopolysaccharide-induced liver injury in the rat.
The Journal of pharmacology and experimental therapeutics 1996;278(1):378-83.
1996: Pearson J M; Brown A P; Schultze A E; Ganey P E; Roth R A
Gadolinium chloride treatment attenuates hepatic platelet accumulation after lipopolysaccharide administration.
Shock (Augusta, Ga.) 1996;5(6):408-15.
1996: Brown A P; Schultze A E; Holdan W L; Buchweitz J P; Roth R A; Ganey P E
Lipopolysaccharide-induced hepatic injury is enhanced by polychlorinated biphenyls.
Environmental health perspectives 1996;104(6):634-40.
1996: Ho J S; Buchweitz J P; Roth R A; Ganey P E
Identification of factors from rat neutrophils responsible for cytotoxicity to isolated hepatocytes.
Journal of leukocyte biology 1996;59(5):716-24.
1996: Wagner J G; Ganey P E; Roth R A
Nitric oxide is not involved in hepatocyte killing by neutrophils activated by N-formyl-methionyl-leucylphenylalanine or phorbol myristate acetate in vitro.
Hepatology (Baltimore, Md.) 1996;23(4):803-10.
1996: Bailie M B; Pearson J M; Fink G D; Roth R A
Platelet activating factor receptor blockade alone or in combination with leukotriene synthesis inhibition does not ameliorate alpha-naphthylisothiocyanate-induced hepatotoxicity.
Toxicology letters 1996;84(2):89-95.
1996: Schultze A E; Emeis J J; Roth R A
Cellular fibronectin and von Willebrand factor concentrations in plasma of rats treated with monocrotaline pyrrole.
Biochemical pharmacology 1996;51(2):187-91.
1995: Jean P A; Roth R A
Naphthylisothiocyanate disposition in bile and its relationship to liver glutathione and toxicity.
Biochemical pharmacology 1995;50(9):1469-74.
1995: Pearson J M; Schultze A E; Jean P A; Roth R A
Platelet participation in liver injury from gram-negative bacterial lipopolysaccharide in the rat.
Shock (Augusta, Ga.) 1995;4(3):178-86.
1995: Bailie M B; Jean P A; Lappin P B; Scozzaro M J; Schmidt T M; Moulin F J; Roth R A
Vitamin A or zymosan pretreatment attenuates alpha-naphthylisothiocyanate-induced liver injury.
Toxicology and applied pharmacology 1995;134(1):63-70.
1995: Bailie M B; Dahm L J; Peters-Golden M; Harris R R; Carter G W; Roth R A
Leukotrienes and alpha-naphthylisothiocyanate-induced liver injury.
Toxicology 1995;100(1-3):139-49.
1995: Jean P A; Bailie M B; Roth R A
1-naphthylisothiocyanate-induced elevation of biliary glutathione.
Biochemical pharmacology 1995;49(2):197-202.
1995: Hoorn C M; Wagner J G; Petry T W; Roth R A
Toxicity of mitomycin C toward cultured pulmonary artery endothelium.
Toxicology and applied pharmacology 1995;130(1):87-94.
1995: Hewett J A; Roth R A
The coagulation system, but not circulating fibrinogen, contributes to liver injury in rats exposed to lipopolysaccharide from gram-negative bacteria.
The Journal of pharmacology and experimental therapeutics 1995;272(1):53-62.
1994: Bailie M B; Pearson J M; Lappin P B; Killam A L; Roth R A
Platelets and alpha-naphthylisothiocyanate-induced liver injury.
Toxicology and applied pharmacology 1994;129(2):207-13.
1994: Schultze A E; Gunaga K P; Wagner J G; Hoorn C M; Moorehead W R; Roth R A
Lactate dehydrogenase activity and isozyme patterns in tissues and bronchoalveolar lavage fluid from rats treated with monocrotaline pyrrole.
Toxicology and applied pharmacology 1994;126(2):301-10.
1994: Ganey P E; Bailie M B; VanCise S; Colligan M E; Madhukar B V; Robinson J P; Roth R A
Activated neutrophils from rat injured isolated hepatocytes.
Laboratory investigation; a journal of technical methods and pathology 1994;70(1):53-60.
1994: Bailie M B; Hewett J A; Schultze A E; Roth R A
Methylene dianiline hepatotoxicity is not leukocyte-dependent.
Toxicology and applied pharmacology 1994;124(1):25-30.
1993: Hewett J A; Jean P A; Kunkel S L; Roth R A
Relationship between tumor necrosis factor-alpha and neutrophils in endotoxin-induced liver injury.
The American journal of physiology 1993;265(6 Pt 1):G1011-5.
1993: Hewett J A; Roth R A
Hepatic and extrahepatic pathobiology of bacterial lipopolysaccharides.
Pharmacological reviews 1993;45(4):382-411.
1993: Hoorn C M; Roth R A
Monocrotaline pyrrole-induced changes in angiotensin-converting enzyme activity of cultured pulmonary artery endothelial cells.
British journal of pharmacology 1993;110(2):597-602.
1993: Ganey P E; Sirois J E; Denison M; Robinson J P; Roth R A
Neutrophil function after exposure to polychlorinated biphenyls in vitro.
Environmental health perspectives 1993;101(5):430-4.
1993: Schultze A E; Roth R A
Procoagulant and fibrinolytic properties of bovine endothelial cells treated with monocrotaline pyrrole.
Toxicology and applied pharmacology 1993;122(1):7-15.
1993: Schultze A E; Roth R A
Fibrinolytic activity in blood and lungs of rats treated with monocrotaline pyrrole.
Toxicology and applied pharmacology 1993;121(1):129-37.
1993: Hoorn C M; Wagner J G; Roth R A
Effects of monocrotaline pyrrole on cultured rat pulmonary endothelium.
Toxicology and applied pharmacology 1993;120(2):281-7.
1993: Bailie M B; Mullaney T P; Roth R A
Characterization of acute 4,4'-methylene dianiline hepatotoxicity in the rat.
Environmental health perspectives 1993;101(2):130-3.
1993: Wagner J G; Petry T W; Roth R A
Characterization of monocrotaline pyrrole-induced DNA cross-linking in pulmonary artery endothelium.
The American journal of physiology 1993;264(5 Pt 1):L517-22.
1992: Bailie M B; Roth R A; Contreras M L
Nerve growth factor binding sites on hepatic parenchymal cells.
In vitro cellular & developmental biology : journal of the Tissue Culture Association 1992;28A(9-10):621-4.
1992: Hoorn C M; Roth R A
Monocrotaline pyrrole alters DNA, RNA and protein synthesis in pulmonary artery endothelial cells.
The American journal of physiology 1992;262(6 Pt 1):L740-7.
1992: Stick J A; Arden W A; Robinson R A; Shobe E M; Roth R A
Thromboxane and prostacyclin production in ponies with colonic volvulus.
American journal of veterinary research 1992;53(4):563-8.
1992: Hewett J A; Schultze A E; VanCise S; Roth R A
Neutrophil depletion protects against liver injury from bacterial endotoxin.
Laboratory investigation; a journal of technical methods and pathology 1992;66(3):347-61.
1991: Reindel J F; Hoorn C M; Wagner J G; Roth R A
Comparison of response of bovine and porcine pulmonary arterial endothelial cells to monocrotaline pyrrole.
The American journal of physiology 1991;261(6 Pt 1):L406-14.
1991: Dahm L J; Schultze A E; Roth R A
Activated neutrophils injure the isolated, perfused rat liver by an oxygen radical-dependent mechanism.
The American journal of pathology 1991;139(5):1009-20.
1991: Dahm L J; Bailie M B; Roth R A
Relationship between alpha-naphthylisothiocyanate-induced liver injury and elevations in hepatic non-protein sulfhydryl content.
Biochemical pharmacology 1991;42(6):1189-94.
1991: Dahm L J; Roth R A
Protection against alpha-naphthylisothiocyanate-induced liver injury by decreased hepatic non-protein sulfhydryl content.
Biochemical pharmacology 1991;42(6):1181-8.
1991: Schultze A E; Wagner J G; Roth R A
An evaluation of procoagulant activity in the peripheral blood of rats treated with monocrotaline pyrrole.
Toxicology and applied pharmacology 1991;109(3):421-31.
1991: Schultze A E; Wagner J G; White S M; Roth R A
Early indications of monocrotaline pyrrole-induced lung injury in rats.
Toxicology and applied pharmacology 1991;109(1):41-50.
1991: Reindel J F; Roth R A
The effects of monocrotaline pyrrole on cultured bovine pulmonary artery endothelial and smooth muscle cells.
The American journal of pathology 1991;138(3):707-19.
1991: Dahm L J; Schultze A E; Roth R A
An antibody to neutrophils attenuates alpha-naphthylisothiocyanate-induced liver injury.
The Journal of pharmacology and experimental therapeutics 1991;256(1):412-20.
1991: Roth R A; Reindel J F
Lung vascular injury from monocrotaline pyrrole, a putative hepatic metabolite.
Advances in experimental medicine and biology 1991;283():477-87.
1991: Durack G; Lawler G; Kelley S; Ragheb K; Roth R A; Ganey P; Robinson J P
Time interval gating for analysis of cell function using flow cytometry.
Cytometry 1991;12(8):701-6.
1990: Reindel J F; Ganey P E; Wagner J G; Slocombe R F; Roth R A
Development of morphologic, hemodynamic, and biochemical changes in lungs of rats given monocrotaline pyrrole.
Toxicology and applied pharmacology 1990;106(2):179-200.
1990: Ahmadizadeh M; Echt R; Heusner W W; Ross L M; Roth R A
Effect of carbon tetrachloride on hamster tracheal epithelial cells.
Journal of toxicology and environmental health 1990;30(4):273-85.
1990: Roth R A; Hewett J A
The cholestatic agent, alpha-naphthylisothiocyanate, stimulates superoxide release by rat neutrophils in vitro.
Laboratory investigation; a journal of technical methods and pathology 1990;62(6):736-41.
1990: Dahm L J; Roth R A
Differential effects of lithocholate on rat neutrophil activation.
Journal of leukocyte biology 1990;47(6):551-60.
1990: Roth R A; Vinegar A
Action by the lungs on circulating xenobiotic agents, with a case study of physiologically based pharmacokinetic modeling of benzo(a)pyrene disposition.
Pharmacology & therapeutics 1990;48(2):143-55.
1989: Carpenter-Deyo L; Roth R A
Cyclooxygenase inhibition in lungs or in neutrophils attenuates neutrophil-dependent edema in rat lungs perfused with phorbol myristate acetate.
The Journal of pharmacology and experimental therapeutics 1989;251(3):983-91.
1989: Gray P R; Derksen F J; Robinson N E; Carpenter-Deyo L J; Johnson H G; Roth R A
The role of cyclooxygenase products in the acute airway obstruction and airway hyperreactivity of ponies with heaves.
The American review of respiratory disease 1989;140(1):154-60.
1989: White S M; Wagner J G; Roth R A
Effects of altered platelet number on pulmonary hypertension and platelet sequestration in monocrotaline pyrrole-treated rats.
Toxicology and applied pharmacology 1989;99(2):302-13.
1988: White S M; Roth R A
Pulmonary platelet sequestration is increased following monocrotaline pyrrole treatment of rats.
Toxicology and applied pharmacology 1988;96(3):465-75.
1988: Ganey P E; Sprugel K H; White S M; Wagner J G; Roth R A
Pulmonary hypertension due to monocrotaline pyrrole is reduced by moderate thrombocytopenia.
The American journal of physiology 1988;255(5 Pt 2):H1165-72.
1988: Hewett J A; Roth R A
Dieldrin activates rat neutrophils in vitro.
Toxicology and applied pharmacology 1988;96(2):269-78.
1988: Dahm L J; Hewett J A; Roth R A
Bile and bile salts potentiate superoxide anion release from activated, rat peritoneal neutrophils.
Toxicology and applied pharmacology 1988;95(1):82-92.
1988: Roth R A; Ganey P E
Platelets and the puzzles of pulmonary pyrrolizidine poisoning.
Toxicology and applied pharmacology 1988;93(3):463-71.
1988: Bruner L H; Johnson K J; Till G O; Roth R A
Complement is not involved in monocrotaline pyrrole-induced pulmonary injury.
The American journal of physiology 1988;254(2 Pt 2):H258-64.
1988: Carpenter L J; Roth R A
Potentiation by piperonyl butoxide of alpha-naphthylthiourea toxicity in the isolated, perfused rat lung.
Biochemical pharmacology 1988;37(4):771-2.
1988: Ganey P E; Roth R A
6-Ketoprostaglandin F1 alpha and thromboxane B2 in isolated, blood-perfused lungs from monocrotaline pyrrole-treated rats.
Journal of toxicology and environmental health 1988;23(1):127-37.
1987: Ganey P E; Roth R A
Elevated serum copper concentration in monocrotaline pyrrole treated rats with pulmonary hypertension.
Biochemical pharmacology 1987;36(20):3535-7.
1987: Carpenter L J; Roth R A
Involvement of thromboxane in injury to isolated rat lungs perfused with phorbol myristate acetate in the presence and absence of neutrophils.
Toxicology and applied pharmacology 1987;91(1):33-45.
1987: Bruner L H; Bull R W; Roth R A
The effect of immunosuppressants and adoptive transfer in monocrotaline pyrrole pneumotoxicity.
Toxicology and applied pharmacology 1987;91(1):1-12.
1987: Carpenter L J; Johnson K J; Kunkel R G; Roth R A
Phorbol myristate acetate produces injury to isolated rat lungs in the presence and absence of perfused neutrophils.
Toxicology and applied pharmacology 1987;91(1):22-32.

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