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Robert Roth

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Aaron M Fullerton; Robert A Roth; Patricia E Ganey
2,3,7,8-TCDD enhances the sensitivity of mice to concanavalin A immune-mediated liver injury.
Jingtao Lu; Kazuhisa Miyakawa; Robert A Roth; Patricia E Ganey
Tumor necrosis factor-alpha potentiates the cytotoxicity of amiodarone in Hepa1c1c7 cells: roles of caspase activation and oxidative stress.
Rohit Singhal; Patricia E Ganey; Robert A Roth
Complement activation in acetaminophen-induced liver injury in mice.

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2013: Aaron M Fullerton; Robert A Roth; Patricia E Ganey
2,3,7,8-TCDD enhances the sensitivity of mice to concanavalin A immune-mediated liver injury.
Toxicology and applied pharmacology 2013;266(2):317-27.
2013: Jingtao Lu; Kazuhisa Miyakawa; Robert A Roth; Patricia E Ganey
Tumor necrosis factor-alpha potentiates the cytotoxicity of amiodarone in Hepa1c1c7 cells: roles of caspase activation and oxidative stress.
Toxicological sciences : an official journal of the Society of Toxicology 2013;131(1):164-78.
2012: Rohit Singhal; Patricia E Ganey; Robert A Roth
Complement activation in acetaminophen-induced liver injury in mice.
The Journal of pharmacology and experimental therapeutics 2012;341(2):377-85.
2012: Erica M Sparkenbaugh; Patricia E Ganey; Robert A Roth
Hypoxia sensitization of hepatocytes to neutrophil elastase-mediated cell death depends on MAPKs and HIF-1α.
American journal of physiology. Gastrointestinal and liver physiology 2012;302(7):G748-57.
2012: Jingtao Lu; Jack R Harkema; Robert A Roth; A Daniel Jones; Patricia E Ganey
Amiodarone exposure during modest inflammation induces idiosyncrasy-like liver injury in rats: role of tumor necrosis factor-alpha.
Toxicological sciences : an official journal of the Society of Toxicology 2012;125(1):126-33.
2011: Wei Zou; Ernst Malle; Robert A Roth; Husam S Younis; Patricia E Ganey
Neutrophil-cytokine interactions in a rat model of sulindac-induced idiosyncratic liver injury.
Toxicology 2011;290(2-3):278-85.
2011: Robert A Roth; Patricia E Ganey
Animal models of idiosyncratic drug-induced liver injury--current status.
Critical reviews in toxicology 2011;41(9):723-39.
2011: Erica M Sparkenbaugh; Yogesh Saini; Bryan L Copple; Patricia E Ganey; Krista K Greenwood; John J LaPres; James P Luyendyk; Jane F Maddox; Robert A Roth
The role of hypoxia-inducible factor-1α in acetaminophen hepatotoxicity.
The Journal of pharmacology and experimental therapeutics 2011;338(2):492-502.
2011: Christine M Dugan; Aaron M Fullerton; Robert A Roth; Patricia E Ganey
Natural killer cells mediate severe liver injury in a murine model of halothane hepatitis.
Toxicological sciences : an official journal of the Society of Toxicology 2011;120(2):507-18.
2010: Patrick J Shaw; Patricia E Ganey; Robert A Roth
Idiosyncratic drug-induced liver injury and the role of inflammatory stress with an emphasis on an animal model of trovafloxacin hepatotoxicity.
Toxicological sciences : an official journal of the Society of Toxicology 2010;118(1):7-18.
2010: Wei Zou; Robert A Roth; Husam S Younis; Lyle Burgoon; Patricia E Ganey
Oxidative stress is important in the pathogenesis of liver injury induced by sulindac and lipopolysaccharide cotreatment.
Toxicology 2010;272(1-3):32-8.
2010: Christine M Dugan; Allen E MacDonald; Robert A Roth; Patricia E Ganey
A mouse model of severe halothane hepatitis based on human risk factors.
The Journal of pharmacology and experimental therapeutics 2010;333(2):364-72.
2010: Daher Ibrahim Aibo; Neil P Birmingham; Ryan Lewandowski; Jane F Maddox; Robert A Roth; Patricia E Ganey; James G Wagner; Jack R Harkema
Acute exposure to ozone exacerbates acetaminophen-induced liver injury in mice.
Toxicological sciences : an official journal of the Society of Toxicology 2010;115(1):267-85.
2010: Robert A Roth; Patricia E Ganey
Intrinsic versus idiosyncratic drug-induced hepatotoxicity--two villains or one?
The Journal of pharmacology and experimental therapeutics 2010;332(3):692-7.
2010: Michael J Liguori; Amy C Ditewig; Jane F Maddox; James P Luyendyk; Lois D Lehman-McKeeman; David M Nelson; Vasanthi M Bhaskaran; Jeffrey F Waring; Patricia E Ganey; Robert A Roth; Eric A G Blomme
Comparison of TNFα to Lipopolysaccharide as an Inflammagen to Characterize the Idiosyncratic Hepatotoxicity Potential of Drugs: Trovafloxacin as an Example.
International journal of molecular sciences 2010;11(11):4697-714.
2010: Jane F Maddox; Chidozie J Amuzie; Maoxiang Li; Sandra W Newport; Erica Sparkenbaugh; Christopher Cuff; James J Pestka; Glenn H Cantor; Robert A Roth; Patricia E Ganey
Bacterial- and viral-induced inflammation increases sensitivity to acetaminophen hepatotoxicity.
Journal of toxicology and environmental health. Part A 2010;73(1):58-73.
2009: Wei Zou; Kevin M Beggs; Erica M Sparkenbaugh; A Daniel Jones; Husam S Younis; Robert A Roth; Patricia E Ganey
Sulindac metabolism and synergy with tumor necrosis factor-alpha in a drug-inflammation interaction model of idiosyncratic liver injury.
The Journal of pharmacology and experimental therapeutics 2009;331(1):114-21.
2009: Patrick J Shaw; Kevin M Beggs; Erica M Sparkenbaugh; Christine M Dugan; Patricia E Ganey; Robert A Roth
Trovafloxacin enhances TNF-induced inflammatory stress and cell death signaling and reduces TNF clearance in a murine model of idiosyncratic hepatotoxicity.
Toxicological sciences : an official journal of the Society of Toxicology 2009;111(2):288-301.
2009: Xiaomin Deng; James P Luyendyk; Patricia E Ganey; Robert A Roth
Inflammatory stress and idiosyncratic hepatotoxicity: hints from animal models.
Pharmacological reviews 2009;61(3):262-82.
2009: Patrick J Shaw; Patricia E Ganey; Robert A Roth
Trovafloxacin enhances the inflammatory response to a Gram-negative or a Gram-positive bacterial stimulus, resulting in neutrophil-dependent liver injury in mice.
The Journal of pharmacology and experimental therapeutics 2009;330(1):72-8.
2009: Patrick J Shaw; Aaron M Fullerton; Michael A Scott; Patricia E Ganey; Robert A Roth
The role of the hemostatic system in murine liver injury induced by coexposure to lipopolysaccharide and trovafloxacin, a drug with idiosyncratic liability.
Toxicology and applied pharmacology 2009;236(3):293-300.
2009: Wei Zou; Sachin S Devi; Erica Sparkenbaugh; Husam S Younis; Robert A Roth; Patricia E Ganey
Hepatotoxic interaction of sulindac with lipopolysaccharide: role of the hemostatic system.
Toxicological sciences : an official journal of the Society of Toxicology 2009;108(1):184-93.
2009: Patrick J Shaw; Amy C Ditewig; Jeffrey F Waring; Michael J Liguori; Eric A Blomme; Patricia E Ganey; Robert A Roth
Coexposure of mice to trovafloxacin and lipopolysaccharide, a model of idiosyncratic hepatotoxicity, results in a unique gene expression profile and interferon gamma-dependent liver injury.
Toxicological sciences : an official journal of the Society of Toxicology 2009;107(1):270-80.
2009: Patrick J Shaw; Patricia E Ganey; Robert A Roth
Tumor necrosis factor alpha is a proximal mediator of synergistic hepatotoxicity from trovafloxacin/lipopolysaccharide coexposure.
The Journal of pharmacology and experimental therapeutics 2009;328(1):62-8.
2008: Xiaomin Deng; Michael J Liguori; Erica M Sparkenbaugh; Jeffrey F Waring; Eric A G Blomme; Patricia E Ganey; Robert A Roth
Gene expression profiles in livers from diclofenac-treated rats reveal intestinal bacteria-dependent and -independent pathways associated with liver injury.
The Journal of pharmacology and experimental therapeutics 2008;327(3):634-44.
2008: Xiaomin Deng; Jingtao Lu; Lois D Lehman-McKeeman; Ernst Malle; David L Crandall; Patricia E Ganey; Robert A Roth
p38 mitogen-activated protein kinase-dependent tumor necrosis factor-alpha-converting enzyme is important for liver injury in hepatotoxic interaction between lipopolysaccharide and ranitidine.
The Journal of pharmacology and experimental therapeutics 2008;326(1):144-52.
2007: Patrick J Shaw; Marie J Hopfensperger; Patricia E Ganey; Robert A Roth
Lipopolysaccharide and trovafloxacin coexposure in mice causes idiosyncrasy-like liver injury dependent on tumor necrosis factor-alpha.
Toxicological sciences : an official journal of the Society of Toxicology 2007;100(1):259-66.
2007: Francis F Tukov; James P Luyendyk; Patricia E Ganey; Robert A Roth
The role of tumor necrosis factor alpha in lipopolysaccharide/ranitidine-induced inflammatory liver injury.
Toxicological sciences : an official journal of the Society of Toxicology 2007;100(1):267-80.
2007: Patricia E Ganey; James P Luyendyk; Sandra W Newport; Theresa M Eagle; Jane F Maddox; Nigel Mackman; Robert A Roth
Role of the coagulation system in acetaminophen-induced hepatotoxicity in mice.
Hepatology (Baltimore, Md.) 2007;46(4):1177-86.
2007: Xiaomin Deng; James P Luyendyk; Wei Zou; Jingtao Lu; Ernst Malle; Patricia E Ganey; Robert A Roth
Neutrophil interaction with the hemostatic system contributes to liver injury in rats cotreated with lipopolysaccharide and ranitidine.
The Journal of pharmacology and experimental therapeutics 2007;322(2):852-61.
2007: Steven A Bezdecny; Peer Karmaus; Robert A Roth; Patricia E Ganey
2,2',4,4'-Tetrachlorobiphenyl upregulates cyclooxygenase-2 in HL-60 cells via p38 mitogen-activated protein kinase and NF-kappaB.
Toxicology and applied pharmacology 2007;221(3):285-94.
2007: KangAe Lee; Robert A Roth; John J LaPres
Hypoxia, drug therapy and toxicity.
Pharmacology & therapeutics 2007;113(2):229-46.
2006: Xiaomin Deng; Robert F Stachlewitz; Michael J Liguori; Eric A G Blomme; Jeffrey F Waring; James P Luyendyk; Jane F Maddox; Patricia E Ganey; Robert A Roth
Modest inflammation enhances diclofenac hepatotoxicity in rats: role of neutrophils and bacterial translocation.
The Journal of pharmacology and experimental therapeutics 2006;319(3):1191-9.
2006: Francis F Tukov; Jane F Maddox; David E Amacher; Walter F Bobrowski; Robert A Roth; Patricia E Ganey
Modeling inflammation-drug interactions in vitro: a rat Kupffer cell-hepatocyte coculture system.
Toxicology in vitro : an international journal published in association with BIBRA 2006;20(8):1488-99.
2006: Bryan L Copple; Robert A Roth; Patricia E Ganey
Anticoagulation and inhibition of nitric oxide synthase influence hepatic hypoxia after monocrotaline exposure.
Toxicology 2006;225(2-3):128-37.
2006: Ina Bergheim; Luping Guo; Molly Anne Davis; Jason C Lambert; Juliane I Beier; Ilinca Duveau; James P Luyendyk; Robert A Roth; Gavin E Arteel
Metformin prevents alcohol-induced liver injury in the mouse: Critical role of plasminogen activator inhibitor-1.
Gastroenterology 2006;130(7):2099-112.
2006: James P Luyendyk; Lois D Lehman-McKeeman; David M Nelson; Vasanthi M Bhaskaran; Timothy P Reilly; Bruce D Car; Glenn H Cantor; Xiaomin Deng; Jane F Maddox; Patricia E Ganey; Robert A Roth
Coagulation-dependent gene expression and liver injury in rats given lipopolysaccharide with ranitidine but not with famotidine.
The Journal of pharmacology and experimental therapeutics 2006;317(2):635-43.
2006: James P Luyendyk; Lois D Lehman-McKeeman; David M Nelson; Vasanthi M Bhaskaran; Timothy P Reilly; Bruce D Car; Glenn H Cantor; Jane F Maddox; Patricia E Ganey; Robert A Roth
Unique gene expression and hepatocellular injury in the lipopolysaccharide-ranitidine drug idiosyncrasy rat model: comparison with famotidine.
Toxicological sciences : an official journal of the Society of Toxicology 2006;90(2):569-85.
2006: Jane F Maddox; James P Luyendyk; Gregory N Cosma; Alan P Breau; Roy H Bible; George G Harrigan; Royston Goodacre; Patricia E Ganey; Glenn H Cantor; Gary L Cockerell; Robert A Roth
Metabonomic evaluation of idiosyncrasy-like liver injury in rats cotreated with ranitidine and lipopolysaccharide.
Toxicology and applied pharmacology 2006;212(1):35-44.
2006: Ina Bergheim; James P Luyendyk; Chad Steele; Gilandra K Russell; Luping Guo; Robert A Roth; Gavin E Arteel
Metformin prevents endotoxin-induced liver injury after partial hepatectomy.
The Journal of pharmacology and experimental therapeutics 2006;316(3):1053-61.
2006: Jeffrey F Waring; Michael J Liguori; James P Luyendyk; Jane F Maddox; Patricia E Ganey; Robert F Stachlewitz; Colin North; Eric A G Blomme; Robert A Roth
Microarray analysis of lipopolysaccharide potentiation of trovafloxacin-induced liver injury in rats suggests a role for proinflammatory chemokines and neutrophils.
The Journal of pharmacology and experimental therapeutics 2006;316(3):1080-7.
2006: Elahé T Crockett; James J Galligan; Bruce D Uhal; Jack Harkema; Robert A Roth; Kinnari Pandya
Protection of early phase hepatic ischemia-reperfusion injury by cholinergic agonists.
BMC clinical pathology 2006;6():3.
2005: James P Luyendyk; Patrick J Shaw; Christopher D Green; Jane F Maddox; Patricia E Ganey; Robert A Roth
Coagulation-mediated hypoxia and neutrophil-dependent hepatic injury in rats given lipopolysaccharide and ranitidine.
The Journal of pharmacology and experimental therapeutics 2005;314(3):1023-31.
2005: Robert A Roth; Patricia E Ganey
Successes and frustrations in developing animal models of idiosyncratic drug reactions.
Chemico-biological interactions 2005;152(2-3):165; author reply 167-8.
2005: Steven A Bezdecny; Robert A Roth; Patricia E Ganey
Effects of 2,2',4,4'-tetrachlorobiphenyl on granulocytic HL-60 cell function and expression of cyclooxygenase-2.
Toxicological sciences : an official journal of the Society of Toxicology 2005;84(2):328-34.
2004: James P Luyendyk; Jane F Maddox; Christopher D Green; Patricia E Ganey; Robert A Roth
Role of hepatic fibrin in idiosyncrasy-like liver injury from lipopolysaccharide-ranitidine coexposure in rats.
Hepatology (Baltimore, Md.) 2004;40(6):1342-51.
2004: Patricia E Ganey; James P Luyendyk; Jane F Maddox; Robert A Roth
Adverse hepatic drug reactions: inflammatory episodes as consequence and contributor.
Chemico-biological interactions 2004;150(1):35-51.
2004: James P Luyendyk; William Mattes; Lyle Burgoon; Timothy R Zacharewski; Jane F Maddox; Gregory N Cosma; Patricia E Ganey; Robert A Roth
Gene expression analysis points to hemostasis in livers of rats cotreated with lipopolysaccharide and ranitidine.
Toxicological sciences : an official journal of the Society of Toxicology 2004;80(1):203-13.
2004: Shawn Kinser; Rosie Sneed; Robert A Roth; Patricia E Ganey
Neutrophils contribute to endotoxin enhancement of allyl alcohol hepatotoxicity.
Journal of toxicology and environmental health. Part A 2004;67(12):911-28.
2004: Kristine L Willett; Robert A Roth; Larry Walker
Workshop overview: Hepatotoxicity assessment for botanical dietary supplements.
Toxicological sciences : an official journal of the Society of Toxicology 2004;79(1):4-9.
2004: George G Harrigan; Roxanne H LaPlante; Gregory N Cosma; Gary L Cockerell; Royston Goodacre; Jane F Maddox; James P Luyendyk; Patricia E Ganey; Robert A Roth
Application of high-throughput Fourier-transform infrared spectroscopy in toxicology studies: contribution to a study on the development of an animal model for idiosyncratic toxicity.
Toxicology letters 2004;146(3):197-205.
2004: Jane F Maddox; Alison C Domzalski; Robert A Roth; Patricia E Ganey
15-deoxy prostaglandin J2 enhances allyl alcohol-induced toxicity in rat hepatocytes.
Toxicological sciences : an official journal of the Society of Toxicology 2004;77(2):290-8.
2004: Bryan L Copple; Catherine M Rondelli; Jane F Maddox; Niel C Hoglen; Patricia E Ganey; Robert A Roth
Modes of cell death in rat liver after monocrotaline exposure.
Toxicological sciences : an official journal of the Society of Toxicology 2004;77(1):172-82.
2003: Umesh M Hanumegowda; Bryan L Copple; Masabumi Shibuya; Ernst Malle; Patricia E Ganey; Robert A Roth
Basement membrane and matrix metalloproteinases in monocrotaline-induced liver injury.
Toxicological sciences : an official journal of the Society of Toxicology 2003;76(1):237-46.
2003: Robert A Roth; James P Luyendyk; Jane F Maddox; Patricia E Ganey
Inflammation and drug idiosyncrasy--is there a connection?
The Journal of pharmacology and experimental therapeutics 2003;307(1):1-8.
2003: James P Luyendyk; Jane F Maddox; Gregory N Cosma; Patricia E Ganey; Gary L Cockerell; Robert A Roth
Ranitidine treatment during a modest inflammatory response precipitates idiosyncrasy-like liver injury in rats.
The Journal of pharmacology and experimental therapeutics 2003;307(1):9-16.
2003: Bryan L Copple; Patricia E Ganey; Robert A Roth
Liver inflammation during monocrotaline hepatotoxicity.
Toxicology 2003;190(3):155-69.
2003: Steven Yee; Jack R Harkema; Patricia E Ganey; Robert A Roth
The coagulation system contributes to synergistic liver injury from exposure to monocrotaline and bacterial lipopolysaccharide.
Toxicological sciences : an official journal of the Society of Toxicology 2003;74(2):457-69.
2003: Steven Yee; Umesh M Hanumegowda; Bryan L Copple; Masabumi Shibuya; Patricia E Ganey; Robert A Roth
Endothelial cell injury and coagulation system activation during synergistic hepatotoxicity from monocrotaline and bacterial lipopolysaccharide coexposure.
Toxicological sciences : an official journal of the Society of Toxicology 2003;74(1):203-14.
2003: Jane F Maddox; Robert A Roth; Patricia E Ganey
Allyl alcohol activation of protein kinase C delta leads to cytotoxicity of rat hepatocytes.
Chemical research in toxicology 2003;16(5):609-15.
2003: Bryan L Copple; Frederic Moulin; Umesh M Hanumegowda; Patricia E Ganey; Robert A Roth
Thrombin and protease-activated receptor-1 agonists promote lipopolysaccharide-induced hepatocellular injury in perfused livers.
The Journal of pharmacology and experimental therapeutics 2003;305(2):417-25.
2003: James P Luyendyk; Bryan L Copple; Charles C Barton; Patricia E Ganey; Robert A Roth
Augmentation of aflatoxin B1 hepatotoxicity by endotoxin: involvement of endothelium and the coagulation system.
Toxicological sciences : an official journal of the Society of Toxicology 2003;72(1):171-81.
2003: Steven Yee; Umesh M Hanumegowda; Jon A Hotchkiss; Patricia E Ganey; Robert A Roth
Role of neutrophils in the synergistic liver injury from monocrotaline and bacterial lipopolysaccharide exposure.
Toxicological sciences : an official journal of the Society of Toxicology 2003;72(1):43-56.
2003: Steven Yee; Patricia E Ganey; Robert A Roth
The role of Kupffer cells and TNF-alpha in monocrotaline and bacterial lipopolysaccharide-induced liver injury.
Toxicological sciences : an official journal of the Society of Toxicology 2003;71(1):124-32.
2002: Shawn Kinser; Bryan L Copple; Robert A Roth; Patricia E Ganey
Enhancement of allyl alcohol hepatotoxicity by endotoxin requires extrahepatic factors.
Toxicological sciences : an official journal of the Society of Toxicology 2002;69(2):470-81.
2002: Steven Yee; Bryan L Copple; Patricia E Ganey; Robert A Roth
The temporal relationship between bacterial lipopolysaccharide and monocrotaline exposures influences toxicity: shift in response from hepatotoxicity to nitric oxide-dependent lethality.
Journal of toxicology and environmental health. Part A 2002;65(14):961-76.
2002: James P Luyendyk; Kate C Shores; Patricia E Ganey; Robert A Roth
Bacterial lipopolysaccharide exposure alters aflatoxin B(1) hepatotoxicity: benchmark dose analysis for markers of liver injury.
Toxicological sciences : an official journal of the Society of Toxicology 2002;68(1):220-5.
2002: Bryan L Copple; Brook Woolley; Amy Kissiah Banes-Berceli; Patricia E Ganey; Robert A Roth
Anticoagulants prevent monocrotaline-induced hepatic parenchymal cell injury but not endothelial cell injury in the rat.
Toxicology and applied pharmacology 2002;180(3):186-96.
2002: James G Wagner; Jack R Harkema; Robert A Roth
Pulmonary leukostasis and the inhibition of airway neutrophil recruitment are early events in the endotoxemic rat.
Shock (Augusta, Ga.) 2002;17(2):151-8.
2002: Bryan L Copple; Amy Kissiah Banes-Berceli; Patricia E Ganey; Robert A Roth
Endothelial cell injury and fibrin deposition in rat liver after monocrotaline exposure.
Toxicological sciences : an official journal of the Society of Toxicology 2002;65(2):309-18.
2002: John P Buchweitz; Patricia E Ganey; Steven J Bursian; Robert A Roth
Underlying endotoxemia augments toxic responses to chlorpromazine: is there a relationship to drug idiosyncrasy?
The Journal of pharmacology and experimental therapeutics 2002;300(2):460-7.
2001: Patricia E Ganey; Robert A Roth
Concurrent inflammation as a determinant of susceptibility to toxicity from xenobiotic agents.
Toxicology 2001;169(3):195-208.
2001: F Moulin; Bryan L Copple; Patricia E Ganey; Robert A Roth
Hepatic and extrahepatic factors critical for liver injury during lipopolysaccharide exposure.
American journal of physiology. Gastrointestinal and liver physiology 2001;281(6):G1423-31.
2001: Patricia E Ganey; Y W Barton; Shawn Kinser; Rosie Sneed; Charles C Barton; Robert A Roth
Involvement of cyclooxygenase-2 in the potentiation of allyl alcohol-induced liver injury by bacterial lipopolysaccharide.
Toxicology and applied pharmacology 2001;174(2):113-21.
2001: J Saito; Aimee D Kohn; Robert A Roth; Y Noguchi; I Tatsumo; A Hirai; K Suzuki; Leonard D Kohn; Motoyasu Saji; Matthew D Ringel
Regulation of FRTL-5 thyroid cell growth by phosphatidylinositol (OH) 3 kinase-dependent Akt-mediated signaling.
Thyroid : official journal of the American Thyroid Association 2001;11(4):339-51.
2001: Charles C Barton; E X Barton; Patricia E Ganey; Steven Kunkel; Robert A Roth
Bacterial lipopolysaccharide enhances aflatoxin B1 hepatotoxicity in rats by a mechanism that depends on tumor necrosis factor alpha.
Hepatology (Baltimore, Md.) 2001;33(1):66-73.
2000: Charles C Barton; Patricia E Ganey; Robert A Roth
Lipopolysaccharide augments aflatoxin B(1)-induced liver injury through neutrophil-dependent and -independent mechanisms.
Toxicological sciences : an official journal of the Society of Toxicology 2000;58(1):208-15.
2000: Wilson K Rumbeiha; Scott D Fitzgerald; W Emmett Braselton; Robert A Roth; James J Pestka; John B Kaneene
Augmentation of mercury-induced nephrotoxicity by endotoxin in the mouse.
Toxicology 2000;151(1-3):103-16.
2000: James G Wagner; Robert A Roth
Neutrophil migration mechanisms, with an emphasis on the pulmonary vasculature.
Pharmacological reviews 2000;52(3):349-74.
2000: Wilson K Rumbeiha; Scott D Fitzgerald; W Emmett Braselton; Robert A Roth; John B Kaneene
Potentiation of mercury-induced nephrotoxicity by endotoxin in the Sprague-Dawley rat.
Toxicology 2000;149(2-3):75-87.
2000: Steven Yee; Shawn Kinser; DA Hill; Charles C Barton; Jon A Hotchkiss; Jack R Harkema; Patricia E Ganey; Robert A Roth
Synergistic hepatotoxicity from coexposure to bacterial endotoxin and the pyrrolizidine alkaloid monocrotaline.
Toxicology and applied pharmacology 2000;166(3):173-85.
2000: Charles C Barton; DA Hill; Steven Yee; E X Barton; Patricia E Ganey; Robert A Roth
Bacterial lipopolysaccharide exposure augments aflatoxin B(1)-induced liver injury.
Toxicological sciences : an official journal of the Society of Toxicology 2000;55(2):444-52.
2000: Hui-Ren Zhou; Jack R Harkema; Jon A Hotchkiss; D Yan; Robert A Roth; James J Pestka
Lipopolysaccharide and the trichothecene vomitoxin (deoxynivalenol) synergistically induce apoptosis in murine lymphoid organs.
Toxicological sciences : an official journal of the Society of Toxicology 2000;53(2):253-63.
1999: James G Wagner; Robert A Roth
Neutrophil migration during endotoxemia.
Journal of leukocyte biology 1999;66(1):10-24.
1999: James G Wagner; K E Driscoll; Robert A Roth
Inhibition of pulmonary neutrophil trafficking during endotoxemia is dependent on the stimulus for migration.
American journal of respiratory cell and molecular biology 1999;20(4):769-76.
1999: DA Hill; PA Jean; Robert A Roth
Bile duct epithelial cells exposed to alpha-naphthylisothiocyanate produce a factor that causes neutrophil-dependent hepatocellular injury in vitro.
Toxicological sciences : an official journal of the Society of Toxicology 1999;47(1):118-25.
1998: AE Schultze; Robert A Roth
Chronic pulmonary hypertension--the monocrotaline model and involvement of the hemostatic system.
Journal of toxicology and environmental health. Part B, Critical reviews 1998;1(4):271-346.
1998: PA Jean; S L Kessel; DA Hill; Robert A Roth
Cytotoxicity of naphthylisothiocyanates in rat hepatocyte-neutrophil cocultures.
Toxicology letters 1998;95(3):155-63.
1998: P B Lappin; K L Ross; Louis E King; Pamela J Fraker; Robert A Roth
The response of pulmonary vascular endothelial cells to monocrotaline pyrrole: cell proliferation and DNA synthesis in vitro and in vivo.
Toxicology and applied pharmacology 1998;150(1):37-48.
1998: P K Narayanan; W O Carter; Patricia E Ganey; Robert A Roth; Sherry L Voytik-Harbin; J Robinson
Impairment of human neutrophil oxidative burst by polychlorinated biphenyls: inhibition of superoxide dismutase activity.
Journal of leukocyte biology 1998;63(2):216-24.
1998: DA Hill; Robert A Roth
Alpha-naphthylisothiocyanate causes neutrophils to release factors that are cytotoxic to hepatocytes.
Toxicology and applied pharmacology 1998;148(1):169-75.
1997: R G Molnar; Ping Wang; Alfred Ayala; Patricia E Ganey; Robert A Roth; Irshad H Chaudry
The role of neutrophils in producing hepatocellular dysfunction during the hyperdynamic stage of sepsis in rats.
The Journal of surgical research 1997;73(2):117-22.
1997: Robert A Roth; Jack R Harkema; James J Pestka; Patricia E Ganey
Is exposure to bacterial endotoxin a determinant of susceptibility to intoxication from xenobiotic agents?
Toxicology and applied pharmacology 1997;147(2):300-11.
1997: J M Pearson; Marc Bailie; Gregory D Fink; Robert A Roth
Neither platelet activating factor nor leukotrienes are critical mediators of liver injury after lipopolysaccharide administration.
Toxicology 1997;121(3):181-9.
1997: P B Lappin; Robert A Roth
Hypertrophy and prolonged DNA synthesis in smooth muscle cells characterize pulmonary arterial wall thickening after monocrotaline pyrrole administration to rats.
Toxicologic pathology 1997;25(4):372-80.
1997: AP Brown; Jack R Harkema; A E Schultze; Robert A Roth; Patricia E Ganey
Gadolinium chloride pretreatment protects against hepatic injury but predisposes the lungs to alveolitis after lipopolysaccharide administration.
Shock (Augusta, Ga.) 1997;7(3):186-92.
1997: Michael S Mulligan; E Schmid; Gerd O Till; TE Hugli; HP Friedl; Robert A Roth; Peter A Ward
C5a-dependent up-regulation in vivo of lung vascular P-selectin.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(4):1857-61.
1997: Robert A Roth; L J Dahm
Neutrophil- and glutathione-mediated hepatotoxicity of alpha-naphthylisothiocyanate.
Drug metabolism reviews 1997;29(1-2):153-65.
1996: F Moulin; J M Pearson; A E Schultze; M A Scott; K A Schwartz; J M Davis; Patricia E Ganey; Robert A Roth
Thrombin is a distal mediator of lipopolysaccharide-induced liver injury in the rat.
The Journal of surgical research 1996;65(2):149-58.
1996: Hartmut Jaeschke; C W Smith; M G Clemens; Patricia E Ganey; Robert A Roth
Mechanisms of inflammatory liver injury: adhesion molecules and cytotoxicity of neutrophils.
Toxicology and applied pharmacology 1996;139(2):213-26.
1996: J M Pearson; A E Schultze; K A Schwartz; M A Scott; J M Davis; Robert A Roth
The thrombin inhibitor, hirudin, attenuates lipopolysaccharide-induced liver injury in the rat.
The Journal of pharmacology and experimental therapeutics 1996;278(1):378-83.
1996: J M Pearson; A P Brown; A E Schultze; Patricia E Ganey; Robert A Roth
Gadolinium chloride treatment attenuates hepatic platelet accumulation after lipopolysaccharide administration.
Shock (Augusta, Ga.) 1996;5(6):408-15.
1996: A P Brown; A E Schultze; W L Holdan; J P Buchweitz; Robert A Roth; Patricia E Ganey
Lipopolysaccharide-induced hepatic injury is enhanced by polychlorinated biphenyls.
Environmental health perspectives 1996;104(6):634-40.
1996: J S Ho; J P Buchweitz; Robert A Roth; Patricia E Ganey
Identification of factors from rat neutrophils responsible for cytotoxicity to isolated hepatocytes.
Journal of leukocyte biology 1996;59(5):716-24.
1996: J G Wagner; Patricia E Ganey; Robert A Roth
Nitric oxide is not involved in hepatocyte killing by neutrophils activated by N-formyl-methionyl-leucylphenylalanine or phorbol myristate acetate in vitro.
Hepatology (Baltimore, Md.) 1996;23(4):803-10.
1996: M B Bailie; J M Pearson; Gregory D Fink; Robert A Roth
Platelet activating factor receptor blockade alone or in combination with leukotriene synthesis inhibition does not ameliorate alpha-naphthylisothiocyanate-induced hepatotoxicity.
Toxicology letters 1996;84(2):89-95.
1996: A E Schultze; J J Emeis; Robert A Roth
Cellular fibronectin and von Willebrand factor concentrations in plasma of rats treated with monocrotaline pyrrole.
Biochemical pharmacology 1996;51(2):187-91.
1995: P A Jean; Robert A Roth
Naphthylisothiocyanate disposition in bile and its relationship to liver glutathione and toxicity.
Biochemical pharmacology 1995;50(9):1469-74.
1995: J M Pearson; A E Schultze; P A Jean; Robert A Roth
Platelet participation in liver injury from gram-negative bacterial lipopolysaccharide in the rat.
Shock (Augusta, Ga.) 1995;4(3):178-86.
1995: M B Bailie; P A Jean; P B Lappin; M J Scozzaro; Thomas M Schmidt; F J Moulin; Robert A Roth
Vitamin A or zymosan pretreatment attenuates alpha-naphthylisothiocyanate-induced liver injury.
Toxicology and applied pharmacology 1995;134(1):63-70.
1995: M B Bailie; L J Dahm; Marc Peters-Golden; Richard R Harris; George W Carter; Robert A Roth
Leukotrienes and alpha-naphthylisothiocyanate-induced liver injury.
Toxicology 1995;100(1-3):139-49.
1995: P A Jean; M B Bailie; Robert A Roth
1-naphthylisothiocyanate-induced elevation of biliary glutathione.
Biochemical pharmacology 1995;49(2):197-202.
1995: C M Hoorn; J G Wagner; T W Petry; Robert A Roth
Toxicity of mitomycin C toward cultured pulmonary artery endothelium.
Toxicology and applied pharmacology 1995;130(1):87-94.
1995: James Hewett; Robert A Roth
The coagulation system, but not circulating fibrinogen, contributes to liver injury in rats exposed to lipopolysaccharide from gram-negative bacteria.
The Journal of pharmacology and experimental therapeutics 1995;272(1):53-62.
1994: H M Mehendale; Robert A Roth; A Gandolfi; J E Klaunig; John J Lemasters; L R Curtis
Novel mechanisms in chemically induced hepatotoxicity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1994;8(15):1285-95.
1994: M B Bailie; J M Pearson; P B Lappin; A L Killam; Robert A Roth
Platelets and alpha-naphthylisothiocyanate-induced liver injury.
Toxicology and applied pharmacology 1994;129(2):207-13.
1994: A E Schultze; K P Gunaga; J G Wagner; C M Hoorn; W R Moorehead; Robert A Roth
Lactate dehydrogenase activity and isozyme patterns in tissues and bronchoalveolar lavage fluid from rats treated with monocrotaline pyrrole.
Toxicology and applied pharmacology 1994;126(2):301-10.
1994: Patricia E Ganey; M B Bailie; S VanCise; M E Colligan; Burra V Madhukar; J Robinson; Robert A Roth
Activated neutrophils from rat injured isolated hepatocytes.
Laboratory investigation; a journal of technical methods and pathology 1994;70(1):53-60.
1994: M B Bailie; James Hewett; A E Schultze; Robert A Roth
Methylene dianiline hepatotoxicity is not leukocyte-dependent.
Toxicology and applied pharmacology 1994;124(1):25-30.
1993: James Hewett; P A Jean; Steven Kunkel; Robert A Roth
Relationship between tumor necrosis factor-alpha and neutrophils in endotoxin-induced liver injury.
The American journal of physiology 1993;265(6 Pt 1):G1011-5.
1993: James Hewett; Robert A Roth
Hepatic and extrahepatic pathobiology of bacterial lipopolysaccharides.
Pharmacological reviews 1993;45(4):382-411.
1993: C M Hoorn; Robert A Roth
Monocrotaline pyrrole-induced changes in angiotensin-converting enzyme activity of cultured pulmonary artery endothelial cells.
British journal of pharmacology 1993;110(2):597-602.
1993: Patricia E Ganey; J E Sirois; Michael S Denison; J Robinson; Robert A Roth
Neutrophil function after exposure to polychlorinated biphenyls in vitro.
Environmental health perspectives 1993;101(5):430-4.
1993: A E Schultze; Robert A Roth
Procoagulant and fibrinolytic properties of bovine endothelial cells treated with monocrotaline pyrrole.
Toxicology and applied pharmacology 1993;122(1):7-15.
1993: A E Schultze; Robert A Roth
Fibrinolytic activity in blood and lungs of rats treated with monocrotaline pyrrole.
Toxicology and applied pharmacology 1993;121(1):129-37.
1993: C M Hoorn; J G Wagner; Robert A Roth
Effects of monocrotaline pyrrole on cultured rat pulmonary endothelium.
Toxicology and applied pharmacology 1993;120(2):281-7.
1993: M B Bailie; Thomas P Mullaney; Robert A Roth
Characterization of acute 4,4'-methylene dianiline hepatotoxicity in the rat.
Environmental health perspectives 1993;101(2):130-3.
1993: J G Wagner; T W Petry; Robert A Roth
Characterization of monocrotaline pyrrole-induced DNA cross-linking in pulmonary artery endothelium.
The American journal of physiology 1993;264(5 Pt 1):L517-22.
1992: M B Bailie; Robert A Roth; M L Contreras
Nerve growth factor binding sites on hepatic parenchymal cells.
In vitro cellular & developmental biology : journal of the Tissue Culture Association 1992;28A(9-10):621-4.
1992: C M Hoorn; Robert A Roth
Monocrotaline pyrrole alters DNA, RNA and protein synthesis in pulmonary artery endothelial cells.
The American journal of physiology 1992;262(6 Pt 1):L740-7.
1992: John A Stick; Warwick A Arden; R A Robinson; E M Shobe; Robert A Roth
Thromboxane and prostacyclin production in ponies with colonic volvulus.
American journal of veterinary research 1992;53(4):563-8.
1992: James Hewett; A E Schultze; S VanCise; Robert A Roth
Neutrophil depletion protects against liver injury from bacterial endotoxin.
Laboratory investigation; a journal of technical methods and pathology 1992;66(3):347-61.
1991: J F Reindel; C M Hoorn; J G Wagner; Robert A Roth
Comparison of response of bovine and porcine pulmonary arterial endothelial cells to monocrotaline pyrrole.
The American journal of physiology 1991;261(6 Pt 1):L406-14.
1991: L Carpenter-Deyo; D H Marchand; P A Jean; Robert A Roth; D J Reed
Involvement of glutathione in 1-naphthylisothiocyanate (ANIT) metabolism and toxicity to isolated hepatocytes.
Biochemical pharmacology 1991;42(11):2171-80.
1991: L J Dahm; A E Schultze; Robert A Roth
Activated neutrophils injure the isolated, perfused rat liver by an oxygen radical-dependent mechanism.
The American journal of pathology 1991;139(5):1009-20.
1991: L J Dahm; M B Bailie; Robert A Roth
Relationship between alpha-naphthylisothiocyanate-induced liver injury and elevations in hepatic non-protein sulfhydryl content.
Biochemical pharmacology 1991;42(6):1189-94.
1991: L J Dahm; Robert A Roth
Protection against alpha-naphthylisothiocyanate-induced liver injury by decreased hepatic non-protein sulfhydryl content.
Biochemical pharmacology 1991;42(6):1181-8.
1991: A E Schultze; J G Wagner; Robert A Roth
An evaluation of procoagulant activity in the peripheral blood of rats treated with monocrotaline pyrrole.
Toxicology and applied pharmacology 1991;109(3):421-31.
1991: A E Schultze; J G Wagner; S M White; Robert A Roth
Early indications of monocrotaline pyrrole-induced lung injury in rats.
Toxicology and applied pharmacology 1991;109(1):41-50.
1991: J F Reindel; Robert A Roth
The effects of monocrotaline pyrrole on cultured bovine pulmonary artery endothelial and smooth muscle cells.
The American journal of pathology 1991;138(3):707-19.
1991: P J Provost; John A Stick; Jon S Patterson; Joe G Hauptman; N Edward Robinson; Robert A Roth
Effects of heparin treatment on colonic torsion-associated hemodynamic and plasma eicosanoid changes in anesthetized ponies.
American journal of veterinary research 1991;52(2):289-97.
1991: Robert A Roth; J F Reindel
Lung vascular injury from monocrotaline pyrrole, a putative hepatic metabolite.
Advances in experimental medicine and biology 1991;283():477-87.
1991: L J Dahm; A E Schultze; Robert A Roth
An antibody to neutrophils attenuates alpha-naphthylisothiocyanate-induced liver injury.
The Journal of pharmacology and experimental therapeutics 1991;256(1):412-20.
1991: G Durack; G Lawler; S Kelley; K Ragheb; Robert A Roth; Patricia E Ganey; J Robinson
Time interval gating for analysis of cell function using flow cytometry.
Cytometry 1991;12(8):701-6.
1990: J F Reindel; Patricia E Ganey; J G Wagner; R F Slocombe; Robert A Roth
Development of morphologic, hemodynamic, and biochemical changes in lungs of rats given monocrotaline pyrrole.
Toxicology and applied pharmacology 1990;106(2):179-200.
1990: M Ahmadizadeh; R Echt; W W Heusner; L M Ross; Robert A Roth
Effect of carbon tetrachloride on hamster tracheal epithelial cells.
Journal of toxicology and environmental health 1990;30(4):273-85.
1990: Robert A Roth; James Hewett
The cholestatic agent, alpha-naphthylisothiocyanate, stimulates superoxide release by rat neutrophils in vitro.
Laboratory investigation; a journal of technical methods and pathology 1990;62(6):736-41.
1990: L J Dahm; Robert A Roth
Differential effects of lithocholate on rat neutrophil activation.
Journal of leukocyte biology 1990;47(6):551-60.
1990: Robert A Roth; A Vinegar
Action by the lungs on circulating xenobiotic agents, with a case study of physiologically based pharmacokinetic modeling of benzo(a)pyrene disposition.
Pharmacology & therapeutics 1990;48(2):143-55.
1989: L Carpenter-Deyo; Robert A Roth
Cyclooxygenase inhibition in lungs or in neutrophils attenuates neutrophil-dependent edema in rat lungs perfused with phorbol myristate acetate.
The Journal of pharmacology and experimental therapeutics 1989;251(3):983-91.
1989: P R Gray; Frederik J Derksen; N Edward Robinson; L J Carpenter-Deyo; H G Johnson; Robert A Roth
The role of cyclooxygenase products in the acute airway obstruction and airway hyperreactivity of ponies with heaves.
The American review of respiratory disease 1989;140(1):154-60.
1989: S M White; J G Wagner; Robert A Roth
Effects of altered platelet number on pulmonary hypertension and platelet sequestration in monocrotaline pyrrole-treated rats.
Toxicology and applied pharmacology 1989;99(2):302-13.
1988: S M White; Robert A Roth
Pulmonary platelet sequestration is increased following monocrotaline pyrrole treatment of rats.
Toxicology and applied pharmacology 1988;96(3):465-75.
1988: Patricia E Ganey; K H Sprugel; S M White; J G Wagner; Robert A Roth
Pulmonary hypertension due to monocrotaline pyrrole is reduced by moderate thrombocytopenia.
The American journal of physiology 1988;255(5 Pt 2):H1165-72.
1988: James Hewett; Robert A Roth
Dieldrin activates rat neutrophils in vitro.
Toxicology and applied pharmacology 1988;96(2):269-78.
1988: L J Dahm; James Hewett; Robert A Roth
Bile and bile salts potentiate superoxide anion release from activated, rat peritoneal neutrophils.
Toxicology and applied pharmacology 1988;95(1):82-92.
1988: Robert A Roth; Patricia E Ganey
Platelets and the puzzles of pulmonary pyrrolizidine poisoning.
Toxicology and applied pharmacology 1988;93(3):463-71.
1988: L J Carpenter; Robert A Roth
Potentiation by piperonyl butoxide of alpha-naphthylthiourea toxicity in the isolated, perfused rat lung.
Biochemical pharmacology 1988;37(4):771-2.
1988: L H Bruner; Kent J Johnson; G O Till; Robert A Roth
Complement is not involved in monocrotaline pyrrole-induced pulmonary injury.
The American journal of physiology 1988;254(2 Pt 2):H258-64.
1988: Patricia E Ganey; Robert A Roth
6-Ketoprostaglandin F1 alpha and thromboxane B2 in isolated, blood-perfused lungs from monocrotaline pyrrole-treated rats.
Journal of toxicology and environmental health 1988;23(1):127-37.
1987: Patricia E Ganey; Robert A Roth
Elevated serum copper concentration in monocrotaline pyrrole treated rats with pulmonary hypertension.
Biochemical pharmacology 1987;36(20):3535-7.
1987: L J Carpenter; Robert A Roth
Involvement of thromboxane in injury to isolated rat lungs perfused with phorbol myristate acetate in the presence and absence of neutrophils.
Toxicology and applied pharmacology 1987;91(1):33-45.
1987: L H Bruner; R W Bull; Robert A Roth
The effect of immunosuppressants and adoptive transfer in monocrotaline pyrrole pneumotoxicity.
Toxicology and applied pharmacology 1987;91(1):1-12.
1987: L J Carpenter; Kent J Johnson; R G Kunkel; Robert A Roth
Phorbol myristate acetate produces injury to isolated rat lungs in the presence and absence of perfused neutrophils.
Toxicology and applied pharmacology 1987;91(1):22-32.
1987: Robert A Roth; Patricia E Ganey
Arachidonic acid metabolites and the mechanisms of monocrotaline pneumotoxicity.
The American review of respiratory disease 1987;136(3):762-5.
1987: Patricia E Ganey; Robert A Roth
5-Hydroxytryptamine and thromboxane in platelets from rats treated with monocrotaline pyrrole.
Toxicology and applied pharmacology 1987;88(2):157-64.
1987: Patricia E Ganey; Robert A Roth
Thromboxane does not mediate pulmonary vascular response to monocrotaline pyrrole.
The American journal of physiology 1987;252(4 Pt 2):H743-8.
1987: L H Bruner; Kent J Johnson; L J Carpenter; Robert A Roth
Lack of effect of deferoxamine, dimethyl sulfoxide, and catalase on monocrotaline pyrrole pulmonary injury.
Journal of toxicology and environmental health 1987;21(1-2):205-17.
1987: Patricia E Ganey; Robert A Roth
6-keto prostaglandin F1 alpha and thromboxane B2 in isolated, buffer-perfused lungs from monocrotaline pyrrole-treated rats.
Experimental lung research 1987;12(3):195-206.
1986: L H Bruner; L J Carpenter; P Hamlow; Robert A Roth
Effect of a mixed function oxidase inducer and inhibitor on monocrotaline pyrrole pneumotoxicity.
Toxicology and applied pharmacology 1986;85(3):416-27.
1986: Robert A Roth; T M Ball
Technical grade but not recrystallized alpha-naphthylthiourea potentiates superoxide release by rat neutrophils stimulated in vitro by phorbol myristate acetate.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1986;7(2):324-8.
1986: Patricia E Ganey; K H Sprugel; K B Hadley; Robert A Roth
Monocrotaline pyrrole-induced cardiopulmonary toxicity is not altered by metergoline or ketanserin.
The Journal of pharmacology and experimental therapeutics 1986;237(1):226-31.
1985: Patricia E Ganey; Gregory D Fink; Robert A Roth
The effect of dietary restriction and altered sodium intake on the cardiopulmonary toxicity of monocrotaline pyrrole.
Toxicology and applied pharmacology 1985;78(1):55-62.
1985: K S Hilliker; Robert A Roth
Injury to the isolated, perfused lung by exposure in vitro to monocrotaline pyrrole.
Experimental lung research 1985;8(4):201-12.
1985: K S Hilliker; Robert A Roth
Increased vascular responsiveness in lungs of rats with pulmonary hypertension induced by monocrotaline pyrrole.
The American review of respiratory disease 1985;131(1):46-50.
1984: K S Hilliker; M Imlay; Robert A Roth
Effects of monocrotaline treatment on norepinephrine removal by isolated, perfused rat lungs.
Biochemical pharmacology 1984;33(16):2690-2.
1984: K S Hilliker; T G Bell; D Lorimer; Robert A Roth
Effects of thrombocytopenia on monocrotaline pyrrole-induced pulmonary hypertension.
The American journal of physiology 1984;246(6 Pt 2):H747-53.
1984: K S Hilliker; Robert A Roth
Alteration of monocrotaline pyrrole-induced cardiopulmonary effects in rats by hydrallazine, dexamethasone or sulphinpyrazone.
British journal of pharmacology 1984;82(2):375-80.
1983: K S Hilliker; T G Bell; Robert A Roth
Monocrotaline pyrrole-induced pulmonary hypertension in fawn-hooded rats with platelet storage pool deficiency: 5-hydroxytryptamine uptake by isolated, perfused lungs.
Thrombosis and haemostasis 1983;50(4):844-7.
1983: K S Hilliker; J A Deyo; T G Bell; Robert A Roth
Aggregation of platelets from monocrotaline pyrrole-treated rats.
Thrombosis research 1983;32(3):325-33.
1983: D A Wiersma; Robert A Roth
The prediction of benzo[a]pyrene clearance by rat liver and lung from enzyme kinetic data.
Molecular pharmacology 1983;24(2):300-8.
1983: D A Wiersma; Robert A Roth
Total body clearance of circulating benzo(a)pyrene in conscious rats: effect of pretreatment with 3-methylcholanthrene and the role of liver and lung.
The Journal of pharmacology and experimental therapeutics 1983;226(3):661-7.
1983: L H Bruner; K S Hilliker; Robert A Roth
Pulmonary hypertension and ECG changes from monocrotaline pyrrole in the rat.
The American journal of physiology 1983;245(2):H300-6.
1983: K S Hilliker; C M Garcia; Robert A Roth
Effects of monocrotaline and monocrotaline pyrrole on 5-hydroxytryptamine and paraquat uptake by lung slices.
Research communications in chemical pathology and pharmacology 1983;40(2):179-97.
1983: D A Wiersma; Robert A Roth
Clearance of benzo(a)pyrene by isolated rat liver and lung: alterations in perfusion and metabolic capacity.
The Journal of pharmacology and experimental therapeutics 1983;225(1):121-5.
1983: D A Wiersma; W E Braselton; Robert A Roth
The influence of flow on the metabolism of perfused benzo[a]pyrene by isolated rat lung.
Chemico-biological interactions 1983;43(1):1-15.
1982: K S Hilliker; T G Bell; Robert A Roth
Pneumotoxicity and thrombocytopenia after single injection of monocrotaline.
The American journal of physiology 1982;242(4):H573-9.
1982: K M McCormack; Robert A Roth; K B Wallace; L M Ross; J B Hook
Nonrespiratory metabolic function and morphology of lung following exposure to polybrominated biphenyls in rats.
Journal of toxicology and environmental health 1982;9(1):27-39.
1981: Robert A Roth; L A Dotzlaf; B Baranyi; C H Kuo; J B Hook
Effect of monocrotaline ingestion on liver, kidney, and lung of rats.
Toxicology and applied pharmacology 1981;60(2):193-203.
1981: Robert A Roth; L A Dotzlaf
Lack of protection by ascorbic acid from lethality resulting from exposure to 1 atm O2.
Fundamental and applied toxicology : official journal of the Society of Toxicology 1981;1(5):386-8.
1981: Robert A Roth
Effect of pneumotoxicants on lactate dehydrogenase activity in airways of rats.
Toxicology and applied pharmacology 1981;57(1):69-78.
1980: Robert A Roth; K B Wallace
Disposition of biogenic amines and angiotensin I by lungs of spontaneously hypertensive rats.
The American journal of physiology 1980;239(6):H736-41.
1980: K B Wallace; M D Bailie; J B Hook; Robert A Roth
Disposition of 5-hydroxytryptamine in lungs of developing rats.
The American journal of physiology 1980;239(5):R401-6.
1980: K B Wallace; Robert A Roth; J B Hook; M D Bailie
Age-related differences in angiotensin I metabolism by isolated perfused rat lungs.
The American journal of physiology 1980;238(5):R395-9.
1980: K S Hilliker; Robert A Roth
Prediction of mescaline clearance by rabbit lung and liver from enzyme kinetic data.
Biochemical pharmacology 1980;29(2):253-5.
1980: D A Wiersma; Robert A Roth
Clearance of 5-hydroxytryptamine by rat lung and liver: the importance of relative perfusion and intrinsic clearance.
The Journal of pharmacology and experimental therapeutics 1980;212(1):97-102.
1979: Robert A Roth; D A Wiersma
Role of the lung in total body clearance of circulating drugs.
Clinical pharmacokinetics 1979;4(5):355-67.
1979: Robert A Roth; K B Wallace; Richard Alper; M D Bailie
Effect of paraquat treatment of rats on disposition of 5-hydroxytryptamine and angiotensin I by perfused lung.
Biochemical pharmacology 1979;28(15):2349-55.
1978: C N Gillis; R J Huxtable; Robert A Roth
Effects of monocrotaline pretreatment of rats on removal of 5-hydroxytryptamine and noradrenaline by perfused lung.
British journal of pharmacology 1978;63(3):435-43.
1978: Robert A Roth; C N Gillis
Effect of ventilation and pH on removal of mescaline and biogenic amines by rabbit lung.
Journal of applied physiology: respiratory, environmental and exercise physiology 1978;44(4):553-8.
1977: Robert A Roth; C N Gillis
Effect of ventilation on removal of [14C]mescaline by perfused rabbit lung.
Biochemical pharmacology 1977;26(15):1446-8.