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George Rothblat

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Sandhya Sankaranarayanan; Margarita de la Llera-Moya; Denise Drazul-Schrader; Ginny Kellner-Weibel; Michael C Phillips; George H Rothblat
Serum albumin acts as a shuttle to enhance cholesterol efflux from cells.
Robert S Rosenson; George H Rothblat; Alan R Tall; H Bryan Brewer; W Sean Davidson; Zahi A Fayad; Valentin Fuster; James Goldstein; Marc Hellerstein; Xian-Cheng Jiang; Michael C Phillips; Daniel J Rader; Alan T Remaley; Laurent Yvan-Charvet
Cholesterol efflux and atheroprotection: advancing the concept of reverse cholesterol transport.
Ginny L Weibel; Kevin J Yu; Sandra R Bates; W Gray Jerome; Michelle R Joshi; Michael C Phillips; George H Rothblat
Cytoskeleton disruption in J774 macrophages: consequences for lipid droplet formation and cholesterol flux.

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2013: Sandhya Sankaranarayanan; Margarita de la Llera-Moya; Denise Drazul-Schrader; Ginny Kellner-Weibel; Michael C Phillips; George H Rothblat
Serum albumin acts as a shuttle to enhance cholesterol efflux from cells.
Journal of lipid research 2013;54(3):671-6.
2012: Robert S Rosenson; George H Rothblat; Alan R Tall; H Bryan Brewer; W Sean Davidson; Zahi A Fayad; Valentin Fuster; James Goldstein; Marc Hellerstein; Xian-Cheng Jiang; Michael C Phillips; Daniel J Rader; Alan T Remaley; Laurent Yvan-Charvet
Cholesterol efflux and atheroprotection: advancing the concept of reverse cholesterol transport.
Circulation 2012;125(15):1905-19.
2012: Ginny L Weibel; Kevin J Yu; Sandra R Bates; W Gray Jerome; Michelle R Joshi; Michael C Phillips; George H Rothblat
Cytoskeleton disruption in J774 macrophages: consequences for lipid droplet formation and cholesterol flux.
Biochimica et biophysica acta 2012;1821(3):464-72.
2012: William R Lagor; Wen Lin; George H Rothblat; Nathaniel Weintraub; Kaijin Wu; Margarita de la Llera-Moya; Denise Drazul-Schrader; David W Fields; Sarah F Hamm-Alvarez; Sumeet A Khetarpal; Arthi Kumaravel; Daniel J Rader
The effects of apolipoprotein F deficiency on high density lipoprotein cholesterol metabolism in mice.
PloS one 2012;7(2):e31616.
2011: Sandhya Sankaranarayanan; Bela F Asztalos; Robert Bittman; Margarita de la Llera-Moya; Ginny Kellner-Weibel; Michael C Phillips; George H Rothblat
A sensitive assay for ABCA1-mediated cholesterol efflux using BODIPY-cholesterol.
Journal of lipid research 2011;52(12):2332-40.
2011: Ginny L Weibel; Aisha Wilson; Jeffrey Billheimer; Sara Hayes; Michael C Phillips; Daniel J Rader; George H Rothblat
Novel in vivo method for measuring cholesterol mass flux in peripheral macrophages.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(12):2865-71.
2011: Saj Parathath; George H Rothblat; Ginny L Weibel; Snjezana Dogan; Snigdha Ghosh; Liang Guo; Earl H Harrison; Victor A Joaquin; Edward A Fisher
Rat carboxylesterase ES-4 enzyme functions as a major hepatic neutral cholesteryl ester hydrolase.
The Journal of biological chemistry 2011;286(46):39683-92.
2011: Omar L Francone; Christiane Happe; Brian Y Ishida; John P Kane; Al Burlingame; Robert J Chalkey; Cheryl Cox; Margarita de la Llera-Moya; Lori Royer; Peter Schaefer; Jian Zhu; George H Rothblat
Disruption of the murine procollagen C-proteinase enhancer 2 gene causes accumulation of pro-apoA-I and increased HDL levels.
Journal of lipid research 2011;52(11):1974-83.
2011: Lindsey R Boone; William R Lagor; Melissa I Niesen; George H Rothblat; Margarita de la Llera-Moya; Gene C Ness
Thyroid hormone enhances the ability of serum to accept cellular cholesterol via the ABCA1 transporter.
Atherosclerosis 2011;218(1):77-82.
2011: Eric T Alexander; Charulatha Vedhachalam; Sandhya Sankaranarayanan; Margarita de la Llera-Moya; George H Rothblat; Daniel J Rader; Michael C Phillips
Influence of apolipoprotein A-I domain structure on macrophage reverse cholesterol transport in mice.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(2):320-7.
2011: Amit V Khera; Marina Cuchel; Margarita de la Llera-Moya; Amrith Rodrigues; Megan F Burke; Kashif Jafri; Benjamin C French; Julie A Phillips; Megan L Mucksavage; Robert L Wilensky; Emile R Mohler; George H Rothblat; Daniel J Rader
Cholesterol efflux capacity, high-density lipoprotein function, and atherosclerosis.
The New England journal of medicine 2011;364(2):127-35.
2010: Sandhya Sankaranarayanan; Margarita de la Llera-Moya; Denise Drazul-Schrader; Bela F Asztalos; Ginny L Weibel; George H Rothblat
Importance of macrophage cholesterol content on the flux of cholesterol mass.
Journal of lipid research 2010;51(11):3243-9.
2010: Charulatha Vedhachalam; Palaniappan Sevugan Chetty; Margaret Nickel; Padmaja Dhanasekaran; Sissel Lund-Katz; George H Rothblat; Michael C Phillips
Influence of apolipoprotein (Apo) A-I structure on nascent high density lipoprotein (HDL) particle size distribution.
The Journal of biological chemistry 2010;285(42):31965-73.
2010: Robert J Brown; William R Lagor; Sandhya Sankaranaravanan; Tomoyuki Yasuda; Thomas Quertermous; George H Rothblat; Daniel J Rader
Impact of combined deficiency of hepatic lipase and endothelial lipase on the metabolism of both high-density lipoproteins and apolipoprotein B-containing lipoproteins.
Circulation research 2010;107(3):357-64.
2010: George H Rothblat; Michael C Phillips
High-density lipoprotein heterogeneity and function in reverse cholesterol transport.
Current opinion in lipidology 2010;21(3):229-38.
2010: Margarita de la Llera-Moya; Denise Drazul-Schrader; Bela F Asztalos; Marina Cuchel; Daniel J Rader; George H Rothblat
The ability to promote efflux via ABCA1 determines the capacity of serum specimens with similar high-density lipoprotein cholesterol to remove cholesterol from macrophages.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(4):796-801.
2010: Yuzhen Zhang; Fiona C McGillicuddy; Christine C Hinkle; Sean O'Neill; Jane M Glick; George H Rothblat; Muredach P Reilly
Adipocyte modulation of high-density lipoprotein cholesterol.
Circulation 2010;121(11):1347-55.
2010: Marina Cuchel; Sissel Lund-Katz; Margarita de la Llera-Moya; John S Millar; David Chang; Ilia V Fuki; George H Rothblat; Michael C Phillips; Daniel J Rader
Pathways by which reconstituted high-density lipoprotein mobilizes free cholesterol from whole body and from macrophages.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(3):526-32.
2009: Ginny L Weibel; Michelle R Joshi; Cong Wei; Sandra R Bates; Ian A Blair; George H Rothblat
15(S)-Lipoxygenase-1 associates with neutral lipid droplets in macrophage foam cells: evidence of lipid droplet metabolism.
Journal of lipid research 2009;50(12):2371-6.
2009: Eric T Alexander; Ginny L Weibel; Michelle R Joshi; Charulatha Vedhachalam; Margarita de la Llera-Moya; George H Rothblat; Michael C Phillips; Daniel J Rader
Macrophage reverse cholesterol transport in mice expressing ApoA-I Milano.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(10):1496-501.
2009: Tomoyuki Nishimoto; Michael Pellizzon; Masakazu Aihara; Ioannis M Stylianou; Jeffery T Billheimer; George H Rothblat; Daniel J Rader
Fish oil promotes macrophage reverse cholesterol transport in mice.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(10):1502-8.
2009: Hiroyuki Tanigawa; Jeffrey T Billheimer; Jun-ichiro Tohyama; Ilia V Fuki; Dominic S Ng; George H Rothblat; Daniel J Rader
Lecithin: cholesterol acyltransferase expression has minimal effects on macrophage reverse cholesterol transport in vivo.
Circulation 2009;120(2):160-9.
2009: Ginny L Weibel; Michelle R Joshi; Eric T Alexander; Peijuan Zhu; Ian A Blair; George H Rothblat
Overexpression of human 15(S)-lipoxygenase-1 in RAW macrophages leads to increased cholesterol mobilization and reverse cholesterol transport.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(6):837-42.
2009: Junichiro Tohyama; Jeffrey T Billheimer; Ilia V Fuki; George H Rothblat; Daniel J Rader; John S Millar
Effects of nevirapine and efavirenz on HDL cholesterol levels and reverse cholesterol transport in mice.
Atherosclerosis 2009;204(2):418-23.
2009: Daniel J Rader; Eric T Alexander; Ginny L Weibel; Jeffrey T Billheimer; George H Rothblat
The role of reverse cholesterol transport in animals and humans and relationship to atherosclerosis.
Journal of lipid research 2009;50 Suppl():S189-94.
2009: Fiona C McGillicuddy; Margarita de la Llera-Moya; Christine C Hinkle; Michelle R Joshi; Elise H Chiquoine; Jeffrey T Billheimer; George H Rothblat; Muredach P Reilly
Inflammation impairs reverse cholesterol transport in vivo.
Circulation 2009;119(8):1135-45.
2009: Sandhya Sankaranarayanan; John F Oram; Bela F Asztalos; Ashley M Vaughan; Sissel Lund-Katz; Maria Pia Adorni; Michael C Phillips; George H Rothblat
Effects of acceptor composition and mechanism of ABCG1-mediated cellular free cholesterol efflux.
Journal of lipid research 2009;50(2):275-84.
2008: Phu T Duong; Ginny L Weibel; Sissel Lund-Katz; George H Rothblat; Michael C Phillips
Characterization and properties of pre beta-HDL particles formed by ABCA1-mediated cellular lipid efflux to apoA-I.
Journal of lipid research 2008;49(5):1006-14.
2008: Sandra R Bates; Jian-Qin Tao; Kevin J Yu; Zea Borok; Edward D Crandall; Heidi L Collins; George H Rothblat
Expression and biological activity of ABCA1 in alveolar epithelial cells.
American journal of respiratory cell and molecular biology 2008;38(3):283-92.
2007: Maria Pia Adorni; Francesca Zimetti; Jeffrey T Billheimer; Nan Wang; Daniel J Rader; Michael C Phillips; George H Rothblat
The roles of different pathways in the release of cholesterol from macrophages.
Journal of lipid research 2007;48(11):2453-62.
2007: Hiroyuki Tanigawa; Jeffrey T Billheimer; Jun-ichiro Tohyama; YuZhen Zhang; George H Rothblat; Daniel J Rader
Expression of cholesteryl ester transfer protein in mice promotes macrophage reverse cholesterol transport.
Circulation 2007;116(11):1267-73.
2007: Ginny L Weibel; Eric T Alexander; Michelle R Joshi; Daniel J Rader; Sissel Lund-Katz; Michael C Phillips; George H Rothblat
Wild-type ApoA-I and the Milano variant have similar abilities to stimulate cellular lipid mobilization and efflux.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(9):2022-9.
2007: Charulatha Vedhachalam; Phu T Duong; Margaret Nickel; David Nguyen; Padmaja Dhanasekaran; Hiroyuki Saito; George H Rothblat; Sissel Lund-Katz; Michael C Phillips
Mechanism of ATP-binding cassette transporter A1-mediated cellular lipid efflux to apolipoprotein A-I and formation of high density lipoprotein particles.
The Journal of biological chemistry 2007;282(34):25123-30.
2007: Weijun Jin; Xun Wang; John S Millar; Thomas Quertermous; George H Rothblat; Jane M Glick; Daniel J Rader
Hepatic proprotein convertases modulate HDL metabolism.
Cell metabolism 2007;6(2):129-36.
2007: Xun Wang; Heidi L Collins; Mollie Ranalletta; Ilia V Fuki; Jeffrey T Billheimer; George H Rothblat; Alan R Tall; Daniel J Rader
Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo.
The Journal of clinical investigation 2007;117(8):2216-24.
2007: Charulatha Vedhachalam; Amy B Ghering; W Sean Davidson; Sissel Lund-Katz; George H Rothblat; Michael C Phillips
ABCA1-induced cell surface binding sites for ApoA-I.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(7):1603-9.
2007: Saloni Tikku; Yulia Epshtein; Heidi Collins; Alexander J Travis; George H Rothblat; Irena Levitan
Relationship between Kir2.1/Kir2.3 activity and their distributions between cholesterol-rich and cholesterol-poor membrane domains.
American journal of physiology. Cell physiology 2007;293(1):C440-50.
2007: Saj Parathath; Yolanda F Darlington; Margarita de la Llera-Moya; Denise Drazul-Schrader; David L Williams; Michael C Phillips; George H Rothblat; Margery A Connelly
Effects of amino acid substitutions at glycine 420 on SR-BI cholesterol transport function.
Journal of lipid research 2007;48(6):1386-95.
2007: Lee A Morehouse; Eliot D Sugarman; Patricia-Ann Bourassa; Thomas M Sand; Francesca Zimetti; Feng Gao; George H Rothblat; Anthony J Milici
Inhibition of CETP activity by torcetrapib reduces susceptibility to diet-induced atherosclerosis in New Zealand White rabbits.
Journal of lipid research 2007;48(6):1263-72.
2006: Roshni R Singaraja; Miranda van Eck; Nagat Bissada; Francesca Zimetti; Heidi L Collins; Reeni B Hildebrand; Anna Hayden; Liam R Brunham; Martin H Kang; Jean-Charles Fruchart; Theo Van berkel; John S Parks; Bart Staels; George H Rothblat; Catherine Fiévet; Michael R Hayden
Both hepatic and extrahepatic ABCA1 have discrete and essential functions in the maintenance of plasma high-density lipoprotein cholesterol levels in vivo.
Circulation 2006;114(12):1301-9.
2006: Yun Fang; Emile R Mohler; Esther Hsieh; Hashim Osman; Seyed M Hashemi; Peter F Davies; George H Rothblat; Robert L Wilensky; Irena Levitan
Hypercholesterolemia suppresses inwardly rectifying K+ channels in aortic endothelium in vitro and in vivo.
Circulation research 2006;98(8):1064-71.
2006: Fitzroy J Byfield; Saloni Tikku; George H Rothblat; Keith J Gooch; Irena Levitan
OxLDL increases endothelial stiffness, force generation, and network formation.
Journal of lipid research 2006;47(4):715-23.
2006: Phu T Duong; Heidi L Collins; Margaret Nickel; Sissel Lund-Katz; George H Rothblat; Michael C Phillips
Characterization of nascent HDL particles and microparticles formed by ABCA1-mediated efflux of cellular lipids to apoA-I.
Journal of lipid research 2006;47(4):832-43.
2006: Eugene Trogan; Jonathan E Feig; Snjezana Dogan; George H Rothblat; Véronique Angeli; Frank Tacke; Gwendalyn J Randolph; Edward A Fisher
Gene expression changes in foam cells and the role of chemokine receptor CCR7 during atherosclerosis regression in ApoE-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(10):3781-6.
2006: MyNgan Duong; Heidi L Collins; Weijun Jin; Ilaria Zanotti; Elda Favari; George H Rothblat
Relative contributions of ABCA1 and SR-BI to cholesterol efflux to serum from fibroblasts and macrophages.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(3):541-7.
2006: Francesca Zimetti; Ginny K Weibel; MyNgan Duong; George H Rothblat
Measurement of cholesterol bidirectional flux between cells and lipoproteins.
Journal of lipid research 2006;47(3):605-13.
2006: Vimal Selvaraj; Atsushi Asano; Danielle E Buttke; John L McElwee; Jacquelyn L Nelson; Collin A Wolff; Tanya Merdiushev; Miguel Walter Fornés; Alex W Cohen; Michael P Lisanti; George H Rothblat; Gregory S Kopf; Alexander J Travis
Segregation of micron-scale membrane sub-domains in live murine sperm.
Journal of cellular physiology 2006;206(3):636-46.
2006: Snehal U Naik; Xun Wang; Jaqueline S Da Silva; Michael Jaye; Colin H Macphee; Muredach P Reilly; Jeffrey T Billheimer; George H Rothblat; Daniel J Rader
Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo.
Circulation 2006;113(1):90-7.
2005: Sandra R Bates; Jian-Qin Tao; Heidi L Collins; Omar L Francone; George H Rothblat
Pulmonary abnormalities due to ABCA1 deficiency in mice.
American journal of physiology. Lung cellular and molecular physiology 2005;289(6):L980-9.
2005: Ryan E Moore; Mohamad Navab; John S Millar; Francesca Zimetti; Susan Hama; George H Rothblat; Daniel J Rader
Increased atherosclerosis in mice lacking apolipoprotein A-I attributable to both impaired reverse cholesterol transport and increased inflammation.
Circulation research 2005;97(8):763-71.
2005: YuZhen Zhang; Jaqueline R Da Silva; Muredach Reilly; Jeffrey T Billheimer; George H Rothblat; Daniel J Rader
Hepatic expression of scavenger receptor class B type I (SR-BI) is a positive regulator of macrophage reverse cholesterol transport in vivo.
The Journal of clinical investigation 2005;115(10):2870-4.
2005: Bela F Asztalos; Margarita de la Llera-Moya; Gerard Dallal; Katalin V Horvath; Ernst Schaefer; George H Rothblat
Differential effects of HDL subpopulations on cellular ABCA1- and SR-BI-mediated cholesterol efflux.
Journal of lipid research 2005;46(10):2246-53.
2004: Elda Favari; Ilaria Zanotti; Francesca Zimetti; Nicoletta Ronda; Franco Bernini; George H Rothblat
Probucol inhibits ABCA1-mediated cellular lipid efflux.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(12):2345-50.
2004: Victor G Romanenko; Yun Fang; Fitzroy J Byfield; Alexander J Travis; Carol A Vandenberg; George H Rothblat; Irena Levitan
Cholesterol sensitivity and lipid raft targeting of Kir2.1 channels.
Biophysical journal 2004;87(6):3850-61.
2004: Charulatha Vedhachalam; Lijuan Liu; Margaret Nickel; Padmaja Dhanasekaran; G M Anantharamaiah; Sissel Lund-Katz; George H Rothblat; Michael C Phillips
Influence of ApoA-I structure on the ABCA1-mediated efflux of cellular lipids.
The Journal of biological chemistry 2004;279(48):49931-9.
2004: Fitzroy J Byfield; Helim Aranda-Espinoza; Victor G Romanenko; George H Rothblat; Irena Levitan
Cholesterol depletion increases membrane stiffness of aortic endothelial cells.
Biophysical journal 2004;87(5):3336-43.
2004: Saj Parathath; Margery A Connelly; Robert A Rieger; Seth M Klein; Nada A Abumrad; Margarita de la Llera-Moya; Charles R Iden; George H Rothblat; David L Williams
Changes in plasma membrane properties and phosphatidylcholine subspecies of insect Sf9 cells due to expression of scavenger receptor class B, type I, and CD36.
The Journal of biological chemistry 2004;279(40):41310-8.
2004: Patricia G Yancey; Bela F Asztalos; Nicolas Stettler; David A Piccoli; David L Williams; Margery A Connelly; George H Rothblat
SR-BI- and ABCA1-mediated cholesterol efflux to serum from patients with Alagille syndrome.
Journal of lipid research 2004;45(9):1724-32.
2004: Ilaria Zanotti; Elda Favari; Andrei Sposito; George H Rothblat; Franco Bernini
Pitavastatin increases ABCA1-mediated lipid efflux from Fu5AH rat hepatoma cells.
Biochemical and biophysical research communications 2004;321(3):670-4.
2004: Saj Parathath; Daisy Sahoo; Yolanda F Darlington; Yinan Peng; Heidi L Collins; George H Rothblat; David L Williams; Margery A Connelly
Glycine 420 near the C-terminal transmembrane domain of SR-BI is critical for proper delivery and metabolism of high density lipoprotein cholesteryl ester.
The Journal of biological chemistry 2004;279(24):24976-85.
2004: Stephen T Thuahnai; Sissel Lund-Katz; Padmaja Dhanasekaran; Margarita de la Llera-Moya; Margery A Connelly; David L Williams; George H Rothblat; Michael C Phillips
Scavenger receptor class B type I-mediated cholesteryl ester-selective uptake and efflux of unesterified cholesterol. Influence of high density lipoprotein size and structure.
The Journal of biological chemistry 2004;279(13):12448-55.
2004: Patricia G Yancey; Masa-aki Kawashiri; Ryan Moore; Jane M Glick; David L Williams; Margery A Connelly; Daniel J Rader; George H Rothblat
In vivo modulation of HDL phospholipid has opposing effects on SR-BI- and ABCA1-mediated cholesterol efflux.
Journal of lipid research 2004;45(2):337-46.
2004: Victor G Romanenko; George H Rothblat; Irena Levitan
Sensitivity of volume-regulated anion current to cholesterol structural analogues.
The Journal of general physiology 2004;123(1):77-87.
2003: Natalie Fournier; Omar L Francone; George H Rothblat; Dominique Goudouneche; Michèle Cambillau; Ginny Kellner-Weibel; Peggy Robinet; Lori Royer; Nicole Moatti; Alain Simon; Jean-Louis Paul
Enhanced efflux of cholesterol from ABCA1-expressing macrophages to serum from type IV hypertriglyceridemic subjects.
Atherosclerosis 2003;171(2):287-93.
2003: Ginny Kellner-Weibel; Steven J Luke; George H Rothblat
Cytotoxic cellular cholesterol is selectively removed by apoA-I via ABCA1.
Atherosclerosis 2003;171(2):235-43.
2003: Fayanne E Thorngate; Patricia G Yancey; Ginny Kellner-Weibel; Lawrence L Rudel; George H Rothblat; David L Williams
Testing the role of apoA-I, HDL, and cholesterol efflux in the atheroprotective action of low-level apoE expression.
Journal of lipid research 2003;44(12):2331-8.
2003: Lijuan Liu; Anna E Bortnick; Margaret Nickel; Padmaja Dhanasekaran; Papasani V Subbaiah; Sissel Lund-Katz; George H Rothblat; Michael C Phillips
Effects of apolipoprotein A-I on ATP-binding cassette transporter A1-mediated efflux of macrophage phospholipid and cholesterol: formation of nascent high density lipoprotein particles.
The Journal of biological chemistry 2003;278(44):42976-84.
2003: Anna E Bortnick; Elda Favari; Jian-Qin Tao; Omar L Francone; Muredach Reilly; Yuzhen Zhang; George H Rothblat; Sandra R Bates
Identification and characterization of rodent ABCA1 in isolated type II pneumocytes.
American journal of physiology. Lung cellular and molecular physiology 2003;285(4):L869-78.
2003: YuZhen Zhang; Ilaria Zanotti; Muredach P Reilly; Jane M Glick; George H Rothblat; Daniel J Rader
Overexpression of apolipoprotein A-I promotes reverse transport of cholesterol from macrophages to feces in vivo.
Circulation 2003;108(6):661-3.
2003: Margery A Connelly; Margarita de la Llera-Moya; Yinan Peng; Denise Drazul-Schrader; George H Rothblat; David L Williams
Separation of lipid transport functions by mutations in the extracellular domain of scavenger receptor class B, type I.
The Journal of biological chemistry 2003;278(28):25773-82.
2003: Patricia G Yancey; Anna E Bortnick; Ginny Kellner-Weibel; Margarita de la Llera-Moya; Michael C Phillips; George H Rothblat
Importance of different pathways of cellular cholesterol efflux.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(5):712-9.
2003: Margery A Connelly; Ginny Kellner-Weibel; George H Rothblat; David L Williams
SR-BI-directed HDL-cholesteryl ester hydrolysis.
Journal of lipid research 2003;44(2):331-41.
2002: Victor G Romanenko; George H Rothblat; Irena Levitan
Modulation of endothelial inward-rectifier K+ current by optical isomers of cholesterol.
Biophysical journal 2002;83(6):3211-22.
2002: George H Rothblat; Margarita de la Llera-Moya; Elda Favari; Patricia G Yancey; Ginny Kellner-Weibel
Cellular cholesterol flux studies: methodological considerations.
Atherosclerosis 2002;163(1):1-8.
2002: Kristin Gillotte-Taylor; Margaret Nickel; William J Johnson; Omar L Francone; Paul Holvoet; Sissel Lund-Katz; George H Rothblat; Michael C Phillips
Effects of enrichment of fibroblasts with unesterified cholesterol on the efflux of cellular lipids to apolipoprotein A-I.
The Journal of biological chemistry 2002;277(14):11811-20.
2001: Margarita de la Llera-Moya; Margery A Connelly; D Drazul; Seth M Klein; Elda Favari; Patricia G Yancey; David L Williams; George H Rothblat
Scavenger receptor class B type I affects cholesterol homeostasis by magnifying cholesterol flux between cells and HDL.
Journal of lipid research 2001;42(12):1969-78.
2001: Margery A Connelly; Margarita de la Llera-Moya; P Monzo; Patricia G Yancey; D Drazul; GW Stoudt; Natalie Fournier; Seth M Klein; George H Rothblat; David L Williams
Analysis of chimeric receptors shows that multiple distinct functional activities of scavenger receptor, class B, type I (SR-BI), are localized to the extracellular receptor domain.
Biochemistry 2001;40(17):5249-59.
2000: Patricia G Yancey; Margarita de la Llera-Moya; S Swarnakar; P Monzo; Seth M Klein; Margery A Connelly; William J Johnson; David L Williams; George H Rothblat
High density lipoprotein phospholipid composition is a major determinant of the bi-directional flux and net movement of cellular free cholesterol mediated by scavenger receptor BI.
The Journal of biological chemistry 2000;275(47):36596-604.
2000: Anna E Bortnick; George H Rothblat; GW Stoudt; Kenneth Hoppe; Lori Royer; John McNeish; Omar L Francone
The correlation of ATP-binding cassette 1 mRNA levels with cholesterol efflux from various cell lines.
The Journal of biological chemistry 2000;275(37):28634-40.
2000: Natalie Fournier; Véronique Atger; Jean-Louis Paul; M Sturm; N Duverger; George H Rothblat; Nicole Moatti
Human ApoA-IV overexpression in transgenic mice induces cAMP-stimulated cholesterol efflux from J774 macrophages to whole serum.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(5):1283-92.
2000: M P Haynes; Michael C Phillips; George H Rothblat
Efflux of cholesterol from different cellular pools.
Biochemistry 2000;39(15):4508-17.
2000: I Levitan; A E Christian; T N Tulenko; George H Rothblat
Membrane cholesterol content modulates activation of volume-regulated anion current in bovine endothelial cells.
The Journal of general physiology 2000;115(4):405-16.
2000: Ginny Kellner-Weibel; Margarita de la Llera-Moya; Margery A Connelly; GW Stoudt; AE Christian; MP Haynes; David L Williams; George H Rothblat
Expression of scavenger receptor BI in COS-7 cells alters cholesterol content and distribution.
Biochemistry 2000;39(1):221-9.
1999: Natalie Fournier; Véronique Atger; J P Paul; Margarita de la Llera-Moya; George H Rothblat; Nicole Moatti
Fractional efflux and net change in cellular cholesterol content mediated by sera from mice expressing both human apolipoprotein AI and human lecithin:cholesterol acyltransferase genes.
Atherosclerosis 1999;147(2):227-35.
1999: Ginny Kellner-Weibel; Y J Geng; George H Rothblat
Cytotoxic cholesterol is generated by the hydrolysis of cytoplasmic cholesteryl ester and transported to the plasma membrane.
Atherosclerosis 1999;146(2):309-19.
1999: David L Williams; Margery A Connelly; Ryan E Temel; S Swarnakar; Michael C Phillips; Margarita de la Llera-Moya; George H Rothblat
Scavenger receptor BI and cholesterol trafficking.
Current opinion in lipidology 1999;10(4):329-39.
1999: Ginny Kellner-Weibel; Patricia G Yancey; W Gray Jerome; T Walser; R P Mason; Michael C Phillips; George H Rothblat
Crystallization of free cholesterol in model macrophage foam cells.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(8):1891-8.
1999: AE Christian; H S Byun; N Zhong; Meni Wanunu; T Marti; A Fürer; F Diederich; R Bittman; George H Rothblat
Comparison of the capacity of beta-cyclodextrin derivatives and cyclophanes to shuttle cholesterol between cells and serum lipoproteins.
Journal of lipid research 1999;40(8):1475-82.
1999: George H Rothblat; Margarita de la Llera-Moya; Véronique Atger; Ginny Kellner-Weibel; David L Williams; Michael C Phillips
Cell cholesterol efflux: integration of old and new observations provides new insights.
Journal of lipid research 1999;40(5):781-96.
1999: S W Sakr; David L Williams; GW Stoudt; Michael C Phillips; George H Rothblat
Induction of cellular cholesterol efflux to lipid-free apolipoprotein A-I by cAMP.
Biochimica et biophysica acta 1999;1438(1):85-98.
1999: Margarita de la Llera-Moya; George H Rothblat; Margery A Connelly; Ginny Kellner-Weibel; S W Sakr; Michael C Phillips; David L Williams
Scavenger receptor BI (SR-BI) mediates free cholesterol flux independently of HDL tethering to the cell surface.
Journal of lipid research 1999;40(3):575-80.
1999: KL Gillotte; Mohamed Zaiou; Sissel Lund-Katz; Gm Anantharamaiah; Paul Holvoet; A Dhoest; Mayakonda N Palgunachari; Jere P Segrest; Karl H Weisgraber; George H Rothblat; Michael C Phillips
Apolipoprotein-mediated plasma membrane microsolubilization. Role of lipid affinity and membrane penetration in the efflux of cellular cholesterol and phospholipid.
The Journal of biological chemistry 1999;274(4):2021-8.
1998: KL Gillotte; Sissel Lund-Katz; Margarita de la Llera-Moya; J S Parks; L L Rudel; George H Rothblat; Michael C Phillips
Dietary modification of high density lipoprotein phospholipid and influence on cellular cholesterol efflux.
Journal of lipid research 1998;39(10):2065-75.
1998: KL Gillotte; W S Davidson; Sissel Lund-Katz; George H Rothblat; Michael C Phillips
Removal of cellular cholesterol by pre-beta-HDL involves plasma membrane microsolubilization.
Journal of lipid research 1998;39(10):1918-28.
1998: L Kritharides; AE Christian; GW Stoudt; D Morel; George H Rothblat
Cholesterol metabolism and efflux in human THP-1 macrophages.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(10):1589-99.
1998: Michael C Phillips; KL Gillotte; M P Haynes; William J Johnson; Sissel Lund-Katz; George H Rothblat
Mechanisms of high density lipoprotein-mediated efflux of cholesterol from cell plasma membranes.
Atherosclerosis 1998;137 Suppl():S13-7.
1998: B Jian; Margarita de la Llera-Moya; Y Ji; Nan Wang; Michael C Phillips; JB Swaney; Alan R Tall; George H Rothblat
Scavenger receptor class B type I as a mediator of cellular cholesterol efflux to lipoproteins and phospholipid acceptors.
The Journal of biological chemistry 1998;273(10):5599-606.
1998: Ginny Kellner-Weibel; W Gray Jerome; D M Small; G J Warner; janet Stoltenborg; M A Kearney; MH Corjay; Michael C Phillips; George H Rothblat
Effects of intracellular free cholesterol accumulation on macrophage viability: a model for foam cell death.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(3):423-31.
1997: Natalie Fournier; Jean-Louis Paul; Véronique Atger; Anne Cogny; T Soni; Margarita de la Llera-Moya; George H Rothblat; Nicole Moatti
HDL phospholipid content and composition as a major factor determining cholesterol efflux capacity from Fu5AH cells to human serum.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(11):2685-91.
1997: AE Christian; MP Haynes; Michael C Phillips; George H Rothblat
Use of cyclodextrins for manipulating cellular cholesterol content.
Journal of lipid research 1997;38(11):2264-72.
1997: Y Ji; B Jian; Nan Wang; Yu Sun; M L Moya; Michael C Phillips; George H Rothblat; JB Swaney; Alan R Tall
Scavenger receptor BI promotes high density lipoprotein-mediated cellular cholesterol efflux.
The Journal of biological chemistry 1997;272(34):20982-5.
1997: B Jian; Margarita de la Llera-Moya; Lori Royer; George H Rothblat; Omar L Francone; JB Swaney
Modification of the cholesterol efflux properties of human serum by enrichment with phospholipid.
Journal of lipid research 1997;38(4):734-44.
1997: Véronique Atger; Margarita de la Llera-Moya; GW Stoudt; WV Rodrigueza; Michael C Phillips; George H Rothblat
Cyclodextrins as catalysts for the removal of cholesterol from macrophage foam cells.
The Journal of clinical investigation 1997;99(4):773-80.
1997: WV Rodrigueza; K J Williams; George H Rothblat; Michael C Phillips
Remodeling and shuttling. Mechanisms for the synergistic effects between different acceptor particles in the mobilization of cellular cholesterol.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(2):383-93.
1997: William J Johnson; Michael C Phillips; George H Rothblat
Lipoproteins and cellular cholesterol homeostasis.
Sub-cellular biochemistry 1997;28():235-76.
1996: KL Gillotte; W S Davidson; Sissel Lund-Katz; George H Rothblat; Michael C Phillips
Apolipoprotein A-I structural modification and the functionality of reconstituted high density lipoprotein particles in cellular cholesterol efflux.
The Journal of biological chemistry 1996;271(39):23792-8.
1996: Diane W Morel; M E Edgerton; G E Warner; William J Johnson; Michael C Phillips; George H Rothblat
Comparison of the intracellular metabolism and trafficking of 25-hydroxycholesterol and cholesterol in macrophages.
Journal of lipid research 1996;37(9):2041-51.
1996: Natalie Fournier; Margarita de la Llera-Moya; B F Burkey; J B Swaney; J Paterniti; Nicole Moatti; Véronique Atger; George H Rothblat
Role of HDL phospholipid in efflux of cell cholesterol to whole serum: studies with human apoA-I transgenic rats.
Journal of lipid research 1996;37(8):1704-11.
1996: Patricia G Yancey; WV Rodrigueza; E P Kilsdonk; GW Stoudt; William J Johnson; Michael C Phillips; George H Rothblat
Cellular cholesterol efflux mediated by cyclodextrins. Demonstration Of kinetic pools and mechanism of efflux.
The Journal of biological chemistry 1996;271(27):16026-34.
1996: William J Johnson; G J Warner; Patricia G Yancey; George H Rothblat
Lysosomal metabolism of lipids.
Sub-cellular biochemistry 1996;27():239-93.
1995: Véronique Atger; Margarita de la Llera-Moya; M Bamberger; Omar L Francone; P Cosgrove; A Tall; A Walsh; Nicole Moatti; George H Rothblat
Cholesterol efflux potential of sera from mice expressing human cholesteryl ester transfer protein and/or human apolipoprotein AI.
The Journal of clinical investigation 1995;96(6):2613-22.
1995: William J Johnson; R T Fischer; Michael C Phillips; George H Rothblat
Efflux of newly synthesized cholesterol and biosynthetic sterol intermediates from cells. Dependence on acceptor type and on enrichment of cells with cholesterol.
The Journal of biological chemistry 1995;270(42):25037-46.
1995: E P Kilsdonk; Patricia G Yancey; GW Stoudt; F W Bangerter; William J Johnson; Michael C Phillips; George H Rothblat
Cellular cholesterol efflux mediated by cyclodextrins.
The Journal of biological chemistry 1995;270(29):17250-6.
1995: W S Davidson; WV Rodrigueza; Sissel Lund-Katz; William J Johnson; George H Rothblat; Michael C Phillips
Effects of acceptor particle size on the efflux of cellular free cholesterol.
The Journal of biological chemistry 1995;270(29):17106-113.
1995: Patricia G Yancey; J K Bielicki; William J Johnson; Sissel Lund-Katz; Mayakonda N Palgunachari; Gm Anantharamaiah; Jere P Segrest; Michael C Phillips; George H Rothblat
Efflux of cellular cholesterol and phospholipid to lipid-free apolipoproteins and class A amphipathic peptides.
Biochemistry 1995;34(24):7955-65.
1995: W S Davidson; KL Gillotte; Sissel Lund-Katz; William J Johnson; George H Rothblat; Michael C Phillips
The effect of high density lipoprotein phospholipid acyl chain composition on the efflux of cellular free cholesterol.
The Journal of biological chemistry 1995;270(11):5882-90.
1995: G J Warner; GW Stoudt; M Bamberger; William J Johnson; George H Rothblat
Cell toxicity induced by inhibition of acyl coenzyme A:cholesterol acyltransferase and accumulation of unesterified cholesterol.
The Journal of biological chemistry 1995;270(11):5772-8.
1995: E P Kilsdonk; Diane W Morel; William J Johnson; George H Rothblat
Inhibition of cellular cholesterol efflux by 25-hydroxycholesterol.
Journal of lipid research 1995;36(3):505-16.
1994: W S Davidson; Sissel Lund-Katz; William J Johnson; Gm Anantharamaiah; Mayakonda N Palgunachari; Jere P Segrest; George H Rothblat; Michael C Phillips
The influence of apolipoprotein structure on the efflux of cellular free cholesterol to high density lipoprotein.
The Journal of biological chemistry 1994;269(37):22975-82.
1994: Margarita de la Llera-Moya; Véronique Atger; Jean-Louis Paul; Natalie Fournier; Nicole Moatti; P Giral; K E Friday; George H Rothblat
A cell culture system for screening human serum for ability to promote cellular cholesterol efflux. Relations between serum components and efflux, esterification, and transfer.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(7):1056-65.
1994: R K Tangirala; W Gray Jerome; N L Jones; D M Small; William J Johnson; Jane M Glick; F H Mahlberg; George H Rothblat
Formation of cholesterol monohydrate crystals in macrophage-derived foam cells.
Journal of lipid research 1994;35(1):93-104.
1993: R K Tangirala; F H Mahlberg; Jane M Glick; W Gray Jerome; George H Rothblat
Lysosomal accumulation of unesterified cholesterol in model macrophage foam cells.
The Journal of biological chemistry 1993;268(13):9653-60.
1992: J K Bielicki; William J Johnson; R B Weinberg; Jane M Glick; George H Rothblat
Efflux of lipid from fibroblasts to apolipoproteins: dependence on elevated levels of cellular unesterified cholesterol.
Journal of lipid research 1992;33(11):1699-709.
1992: Margarita de la Llera-Moya; George H Rothblat; Jane M Glick; J M England
Etoposide treatment suppresses atherosclerotic plaque development in cholesterol-fed rabbits.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1992;12(11):1363-70.
1992: George H Rothblat; F H Mahlberg; William J Johnson; Michael C Phillips
Apolipoproteins, membrane cholesterol domains, and the regulation of cholesterol efflux.
Journal of lipid research 1992;33(8):1091-7.
1992: F H Mahlberg; George H Rothblat
Cellular cholesterol efflux. Role of cell membrane kinetic pools and interaction with apolipoproteins AI, AII, and Cs.
The Journal of biological chemistry 1992;267(7):4541-50.
1991: William J Johnson; E P Kilsdonk; Arie Van Tol; Michael C Phillips; George H Rothblat
Cholesterol efflux from cells to immunopurified subfractions of human high density lipoprotein: LP-AI and LP-AI/AII.
Journal of lipid research 1991;32(12):1993-2000.
1991: F H Mahlberg; Jane M Glick; S Lund-Katz; George H Rothblat
Influence of apolipoproteins AI, AII, and Cs on the metabolism of membrane and lysosomal cholesterol in macrophages.
The Journal of biological chemistry 1991;266(30):19930-7.
1991: William J Johnson; F H Mahlberg; George H Rothblat; Michael C Phillips
Cholesterol transport between cells and high-density lipoproteins.
Biochimica et biophysica acta 1991;1085(3):273-98.
1991: J K Bielicki; William J Johnson; Jane M Glick; George H Rothblat
Efflux of phospholipid from fibroblasts with normal and elevated levels of cholesterol.
Biochimica et biophysica acta 1991;1085(1):7-14.
1991: L K Minor; F H Mahlberg; W Gray Jerome; J C Lewis; George H Rothblat; Jane M Glick
Lysosomal hydrolysis of lipids in a cell culture model of smooth muscle foam cells.
Experimental and molecular pathology 1991;54(2):159-71.
1991: W Gray Jerome; L K Minor; Jane M Glick; George H Rothblat; J C Lewis
Lysosomal lipid accumulation in vascular smooth muscle cells.
Experimental and molecular pathology 1991;54(2):144-58.
1991: D W Bernard; A Rodriguez; George H Rothblat; Jane M Glick
cAMP stimulates cholesteryl ester clearance to high density lipoproteins in J7774 macrophages.
The Journal of biological chemistry 1991;266(2):710-6.
1990: Earl H Harrison; D W Bernard; P Scholm; Daniel M Quinn; George H Rothblat; Jane M Glick
Inhibitors of neutral cholesteryl ester hydrolase.
Journal of lipid research 1990;31(12):2187-93.
1990: F H Mahlberg; A Rodriguez-Oquendo; D W Bernard; Jane M Glick; George H Rothblat
Potential problems in the use of commercial preparations of radiolabeled cholesterol.
Atherosclerosis 1990;84(2-3):95-100.
1990: F H Mahlberg; Jane M Glick; W Gray Jerome; George H Rothblat
Metabolism of cholesteryl ester lipid droplets in a J774 macrophage foam cell model.
Biochimica et biophysica acta 1990;1045(3):291-8.
1990: William J Johnson; G K Chacko; Michael C Phillips; George H Rothblat
The efflux of lysosomal cholesterol from cells.
The Journal of biological chemistry 1990;265(10):5546-53.
1990: D W Bernard; A Rodriguez; George H Rothblat; Jane M Glick
Influence of high density lipoprotein on esterified cholesterol stores in macrophages and hepatoma cells.
Arteriosclerosis (Dallas, Tex.) 1990;10(1):135-44.
1989: L K Minor; George H Rothblat; Jane M Glick
Triglyceride and cholesteryl ester hydrolysis in a cell culture model of smooth muscle foam cells.
Journal of lipid research 1989;30(2):189-97.
1988: H M McCloskey; Jane M Glick; A Catharine Ross; George H Rothblat
Effect of fatty acid supplementation on cholesterol and retinol esterification in J774 macrophages.
Biochimica et biophysica acta 1988;963(3):456-67.
1988: William J Johnson; F H Mahlberg; G K Chacko; Michael C Phillips; George H Rothblat
The influence of cellular and lipoprotein cholesterol contents on the flux of cholesterol between fibroblasts and high density lipoprotein.
The Journal of biological chemistry 1988;263(28):14099-106.
1988: J W Snow; H M McCloskey; Jane M Glick; George H Rothblat; Michael C Phillips
Physical state of cholesteryl esters deposited in cultured macrophages.
Biochemistry 1988;27(10):3640-6.
1987: H M McCloskey; George H Rothblat; Jane M Glick
Incubation of acetylated low-density lipoprotein with cholesterol-rich dispersions enhances cholesterol uptake by macrophages.
Biochimica et biophysica acta 1987;921(2):320-32.
1987: J B Karlin; William J Johnson; C R Benedict; G K Chacko; Michael C Phillips; George H Rothblat
Cholesterol flux between cells and high density lipoprotein. Lack of relationship to specific binding of the lipoprotein to the cell surface.
The Journal of biological chemistry 1987;262(26):12557-64.
1986: G Wolfbauer; Jane M Glick; L K Minor; George H Rothblat
Development of the smooth muscle foam cell: uptake of macrophage lipid inclusions.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(20):7760-4.
1986: William J Johnson; M J Bamberger; R A Latta; P E Rapp; M C Phillips; George H Rothblat
The bidirectional flux of cholesterol between cells and lipoproteins. Effects of phospholipid depletion of high density lipoprotein.
The Journal of biological chemistry 1986;261(13):5766-76.
1986: George H Rothblat; M Bamberger; M C Phillips
Reverse cholesterol transport.
Methods in enzymology 1986;129():628-44.
1985: J E Nestler; M Bamberger; George H Rothblat; Jerome F Strauss
Metabolism of high density lipoproteins reconstituted with [3H]cholesteryl ester and [14C]cholesterol in the rat, with special reference to the ovary.
Endocrinology 1985;117(2):502-10.
1985: M Bamberger; S Lund-Katz; M C Phillips; George H Rothblat
Mechanism of the hepatic lipase induced accumulation of high-density lipoprotein cholesterol by cells in culture.
Biochemistry 1985;24(14):3693-701.
1983: M Bamberger; J M Glick; George H Rothblat
Hepatic lipase stimulates the uptake of high density lipoprotein cholesterol by hepatoma cells.
Journal of lipid research 1983;24(7):869-76.
1982: F P Bell; George H Rothblat; M Bamberger
The effect of lidocaine on cholesterol influx, esterification, and accumulation in cultured cells.
Canadian journal of biochemistry 1982;60(10):967-72.