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Paul Rothman

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Ping Lu; Paul B Rothman; Bruce S Hostager; John D Colgan
Sedimentation and immunoprecipitation assays for analyzing complexes that repress transcription.
Xiaoxue Qiu; Paul B Rothman; Ke Chen; Brian J Druker; Guijie Guo; Masaki Kashiwada; Ji-Long Chen
A requirement for SOCS-1 and SOCS-3 phosphorylation in Bcr-Abl-induced tumorigenesis.
Miranda L Curtiss; Jacob V Gorman; Joel N Kline; David K Meyerholz; Andrew J Murphy; Paul B Rothman; Melody Singh; Geri Traver; David M Valenzuela; Thomas R Businga; John D Colgan; Suzanne L Cassel
Tim-1 regulates Th2 responses in an airway hypersensitivity model.

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2013: Ping Lu; Paul B Rothman; Bruce S Hostager; John D Colgan
Sedimentation and immunoprecipitation assays for analyzing complexes that repress transcription.
Methods in molecular biology (Clifton, N.J.) 2013;977():365-83.
2012: Xiaoxue Qiu; Paul B Rothman; Ke Chen; Brian J Druker; Guijie Guo; Masaki Kashiwada; Ji-Long Chen
A requirement for SOCS-1 and SOCS-3 phosphorylation in Bcr-Abl-induced tumorigenesis.
Neoplasia (New York, N.Y.) 2012;14(6):547-58.
2012: Miranda L Curtiss; Jacob V Gorman; Joel N Kline; David K Meyerholz; Andrew J Murphy; Paul B Rothman; Melody Singh; Geri Traver; David M Valenzuela; Thomas R Businga; John D Colgan; Suzanne L Cassel
Tim-1 regulates Th2 responses in an airway hypersensitivity model.
European journal of immunology 2012;42(3):651-61.
2011: Justin Mostecki; Debra A Stern; Maartje van Peer; Donata Vercelli; Suzanne L Cassel; Penelope Graves; Marilyn Halonen; Sachiyo Iwashita; Walter T Klimecki; Judit Knisz; Fernando D Martinez; Rachel L Miller; Paul B Rothman
A SOCS-1 promoter variant is associated with total serum IgE levels.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(5):2794-802.
2011: Miranda L Curtiss; Bruce S Hostager; Elizabeth Stepniak; Melody Singh; Natalie Manhica; Judit Knisz; Geri Traver; Paul D Rennert; John D Colgan; Paul B Rothman
Fyn binds to and phosphorylates T cell immunoglobulin and mucin domain-1 (Tim-1).
Molecular immunology 2011;48(12-13):1424-31.
2011: Masaki Kashiwada; Suzanne L Cassel; John D Colgan; Paul B Rothman
NFIL3/E4BP4 controls type 2 T helper cell cytokine expression.
The EMBO journal 2011;30(10):2071-82.
2011: Bruce S Hostager; Masaki Kashiwada; John D Colgan; Paul B Rothman
HOIL-1L interacting protein (HOIP) is essential for CD40 signaling.
PloS one 2011;6(8):e23061.
2010: Ping Lu; Isaiah L Hankel; Judit Knisz; Andreas Marquardt; Ming-Yi Chiang; Johannes Grosse; Rainer Constien; Thomas Meyer; Andreas Schroeder; Lutz Zeitlmann; Umaima Al-Alem; Ann D Friedman; Eric I Elliott; David K Meyerholz; Thomas J Waldschmidt; Paul B Rothman; John D Colgan
The Justy mutation identifies Gon4-like as a gene that is essential for B lymphopoiesis.
The Journal of experimental medicine 2010;207(7):1359-67.
2010: Michaela Collins; Mikaela Tremblay; Nicole Chapman; Miranda Curtiss; Paul B Rothman; Jon C D Houtman
The T cell receptor-mediated phosphorylation of Pyk2 tyrosines 402 and 580 occurs via a distinct mechanism than other receptor systems.
Journal of leukocyte biology 2010;87(4):691-701.
2010: Masaki Kashiwada; Deborah M Levy; Lisa McKeag; Keri Murray; Andreas J Schröder; Stephen M Canfield; Geri Traver; Paul B Rothman
IL-4-induced transcription factor NFIL3/E4BP4 controls IgE class switching.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(2):821-6.
2010: Bruce S Hostager; Daniel K Fox; Douglas Whitten; Curtis G Wilkerson; Betty A Eipper; Victor P Francone; Paul B Rothman; John D Colgan
HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex.
PloS one 2010;5(6):e11380.
2009: Jared M Brown; Alex Banks; Lisa McKeag; Dean D Metcalfe; Paul B Rothman; Jared M Brown
Loss of SOCS7 in mice results in severe cutaneous disease and increased mast cell activation.
Clinical immunology (Orlando, Fla.) 2009;132(2):277-84.
2009: Paul B Rothman
Key areas of health care reform of special interest to Iowa.
Iowa medicine : journal of the Iowa Medical Society 2009;99(3):27.
2009: Suzanne L Cassel; Paul B Rothman
Chapter 3: Role of SOCS in allergic and innate immune responses.
Advances in immunology 2009;103():49-76.
2008: Paul B Rothman
A full agenda for all of us.
Iowa medicine : journal of the Iowa Medical Society 2008;98(5):27.
2008: Suzanne L Cassel; Stephanie C Eisenbarth; Shankar S Iyer; Jeffrey J Sadler; Oscar R Colegio; Linda Tephly; A Brent Carter; Paul B Rothman; Richard A Flavell; Fayyaz S Sutterwala
The Nalp3 inflammasome is essential for the development of silicosis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(26):9035-40.
2008: Ji-Long Chen; André Limnander; Paul B Rothman
Pim-1 and Pim-2 kinases are required for efficient pre-B-cell transformation by v-Abl oncogene.
Blood 2008;111(3):1677-85.
2007: Deepa Rastogi; Chaodong Wang; Xia Mao; Cynthia Lendor; Paul B Rothman; Rachel L Miller
Antigen-specific immune responses to influenza vaccine in utero.
The Journal of clinical investigation 2007;117(6):1637-46.
2007: Judit Knisz; Paul B Rothman
Suppressor of cytokine signaling in allergic inflammation.
The Journal of allergy and clinical immunology 2007;119(3):739-45.
2007: John Colgan; Paul B Rothman
Manipulation of signaling to control allergic inflammation.
Current opinion in allergy and clinical immunology 2007;7(1):51-6.
2007: Masaki Kashiwada; Ping Lu; Paul B Rothman
PIP3 pathway in regulatory T cells and autoimmunity.
Immunologic research 2007;39(1-3):194-224.
2006: John Colgan; Paul B Rothman
All in the family: IL-27 suppression of T(H)-17 cells.
Nature immunology 2006;7(9):899-901.
2006: Deepa Rastogi; C Wang; Cynthia Lendor; Paul B Rothman; Rachel L Miller
T-helper type 2 polarization among asthmatics during and following pregnancy.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2006;36(7):892-8.
2006: Masaki Kashiwada; Giorgio Cattoretti; Lisa McKeag; Todd Rouse; Brian M Showalter; Umaima Al-Alem; Masaru Niki; Pier Paolo Pandolfi; Elizabeth H Field; Paul B Rothman
Downstream of tyrosine kinases-1 and Src homology 2-containing inositol 5'-phosphatase are required for regulation of CD4+CD25+ T cell development.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(7):3958-65.
2005: Alexander S Banks; Jianze Li; Lisa McKeag; Marta Letizia Hribal; Masaki Kashiwada; Domenico Accili; Paul B Rothman
Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans.
The Journal of clinical investigation 2005;115(9):2462-71.
2005: Miera B Harris; Justin Mostecki; Paul B Rothman
Repression of an interleukin-4-responsive promoter requires cooperative BCL-6 function.
The Journal of biological chemistry 2005;280(13):13114-21.
2005: Stephen Canfield; Youngnam Lee; Andreas Schröder; Paul B Rothman
Cutting edge: IL-4 induces suppressor of cytokine signaling-3 expression in B cells by a mechanism dependent on activation of p38 MAPK.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(5):2494-8.
2005: Shinji Oki; André Limnander; Pin Mei Yao; Masaru Niki; Pier Paolo Pandolfi; Paul B Rothman
Dok1 and SHIP act as negative regulators of v-Abl-induced pre-B cell transformation, proliferation and Ras/Erk activation.
Cell cycle (Georgetown, Tex.) 2005;4(2):310-4.
2005: Justin Mostecki; Brian M Showalter; Paul B Rothman
Early growth response-1 regulates lipopolysaccharide-induced suppressor of cytokine signaling-1 transcription.
The Journal of biological chemistry 2005;280(4):2596-605.
2004: André Limnander; Paul B Rothman
Abl oncogene bypasses normal regulation of Jak/STAT activation.
Cell cycle (Georgetown, Tex.) 2004;3(12):1486-8.
2004: Nicola M Heller; Satoshi Matsukura; Steve N Georas; Mark R Boothby; Paul B Rothman; Cristiana Stellato; Robert P Schleimer
Interferon-gamma inhibits STAT6 signal transduction and gene expression in human airway epithelial cells.
American journal of respiratory cell and molecular biology 2004;31(5):573-82.
2004: Bao Q Vuong; Teresita L Arenzana; Brian M Showalter; Julie A Losman; X Peter Chen; Justin Mostecki; Alexander S Banks; André Limnander; Neil Fernandez; Paul B Rothman
SOCS-1 localizes to the microtubule organizing complex-associated 20S proteasome.
Molecular and cellular biology 2004;24(20):9092-101.
2004: André Limnander; Nika N Danial; Paul B Rothman
v-Abl signaling disrupts SOCS-1 function in transformed pre-B cells.
Molecular cell 2004;15(3):329-41.
2004: Akinori Arimura; Maartje vn Peer; Andreas J Schröder; Paul B Rothman
The transcriptional co-activator p/CIP (NCoA-3) is up-regulated by STAT6 and serves as a positive regulator of transcriptional activation by STAT6.
The Journal of biological chemistry 2004;279(30):31105-12.
2004: Daphne C Tsitoura; Paul B Rothman
Enhancement of MEK/ERK signaling promotes glucocorticoid resistance in CD4+ T cells.
The Journal of clinical investigation 2004;113(4):619-27.
2003: Han Kim; Guo-Liang Xu; Alain C Borczuk; Steve Busch; Jorge Filmus; Mariana Capurro; Jerome S Brody; Jennifer Lange; Jeanine D'Armiento; Paul B Rothman; Charles A Powell
The heparan sulfate proteoglycan GPC3 is a potential lung tumor suppressor.
American journal of respiratory cell and molecular biology 2003;29(6):694-701.
2003: Rachel L Miller; Matthew Cheng; Emily DiMango; Kimberly Geromanos; Paul B Rothman
T-cell responses and hypersensitivity to influenza and egg antigens among adults with asthma immunized with the influenza vaccine.
The Journal of allergy and clinical immunology 2003;112(3):606-8.
2003: David V Serreze; Melissa A Pierce; Cristina M Post; Harold D Chapman; Holly Savage; Roderick T Bronson; Paul B Rothman; Gregory A Cox
Paralytic autoimmune myositis develops in nonobese diabetic mice made Th1 cytokine-deficient by expression of an IFN-gamma receptor beta-chain transgene.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(5):2742-9.
2003: Julie A Losman; X Peter Chen; Bao Q Vuong; Scott Fay; Paul B Rothman
Protein phosphatase 2A regulates the stability of Pim protein kinases.
The Journal of biological chemistry 2003;278(7):4800-5.
2002: Elena Toniato; X Peter Chen; Julie A Losman; Vincenzo Flati; Liz Donahue; Paul B Rothman
TRIM8/GERP RING finger protein interacts with SOCS-1.
The Journal of biological chemistry 2002;277(40):37315-22.
2002: Shinji Oki; André Limnander; Nika N Danial; Paul B Rothman
Functional involvement of Akt signaling downstream of Jak1 in v-Abl-induced activation of hematopoietic cells.
Blood 2002;100(3):966-73.
2002: Alessandra B Pernis; Paul B Rothman
JAK-STAT signaling in asthma.
The Journal of clinical investigation 2002;109(10):1279-83.
2002: Arnob Banerjee; Alexander S Banks; Martijn C Nawijn; X Peter Chen; Paul B Rothman
Cutting edge: Suppressor of cytokine signaling 3 inhibits activation of NFATp.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(9):4277-81.
2002: Charles A Powell; Guoliang Xu; Jorge Filmus; Steve Busch; Jerome S Brody; Paul B Rothman
Oligonucleotide microarray analysis of lung adenocarcinoma in smokers and nonsmokers identifies GPC3 as a potential lung tumor suppressor.
Chest 2002;121(3 Suppl):6S-7S.
2002: X Peter Chen; Julie A Losman; Simone Cowan; Elizabeth Donahue; Scott Fay; Bao Q Vuong; Martijn C Nawijn; Danielle Capece; Victoria L Cohan; Paul B Rothman
Pim serine/threonine kinases regulate the stability of Socs-1 protein.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(4):2175-80.
2002: Andreas J Schroder; Paul Pavlidis; Akinori Arimura; Danielle Capece; Paul B Rothman
Cutting edge: STAT6 serves as a positive and negative regulator of gene expression in IL-4-stimulated B lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(3):996-1000.
2001: Masaki Kashiwada; CC Giallourakis; PY Pan; Paul B Rothman
Immunoreceptor tyrosine-based inhibitory motif of the IL-4 receptor associates with SH2-containing phosphatases and regulates IL-4-induced proliferation.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(11):6382-7.
2001: GZ Tau; S N Cowan; J Weisburg; Ned S Braunstein; Paul B Rothman
Regulation of IFN-gamma signaling is essential for the cytotoxic activity of CD8(+) T cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(10):5574-82.
2001: Hong Jiang; K Foltenyi; Masaki Kashiwada; L Donahue; Bao Q Vuong; B Hehn; Paul B Rothman
Fes mediates the IL-4 activation of insulin receptor substrate-2 and cellular proliferation.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(4):2627-34.
2000: David V Serreze; Cristina M Post; Harold D Chapman; Ellis A Johnson; B Lu; Paul B Rothman
Interferon-gamma receptor signaling is dispensable in the development of autoimmune type 1 diabetes in NOD mice.
Diabetes 2000;49(12):2007-11.
2000: GZ Tau; T von der Weid; B Lu; S Cowan; M Kvatyuk; Alessandra B Pernis; Giorgio Cattoretti; Ned S Braunstein; Robert L Coffman; Paul B Rothman
Interferon gamma signaling alters the function of T helper type 1 cells.
The Journal of experimental medicine 2000;192(7):977-86.
2000: CC Giallourakis; Masaki Kashiwada; PY Pan; Nika N Danial; Hong Jiang; J Cambier; K Mark Coggeshall; Paul B Rothman
Positive regulation of interleukin-4-mediated proliferation by the SH2-containing inositol-5'-phosphatase.
The Journal of biological chemistry 2000;275(38):29275-82.
2000: X Peter Chen; Julie A Losman; Paul B Rothman
SOCS proteins, regulators of intracellular signaling.
Immunity 2000;13(3):287-90.
2000: Stephen Canfield; Paul B Rothman
TH2 inflammation repressed by chemokines.
Nature immunology 2000;1(3):189-90.
2000: Hong Jiang; Miera B Harris; Paul B Rothman
IL-4/IL-13 signaling beyond JAK/STAT.
The Journal of allergy and clinical immunology 2000;105(6 Pt 1):1063-70.
2000: Nika N Danial; Paul B Rothman
JAK-STAT signaling activated by Abl oncogenes.
Oncogene 2000;19(21):2523-31.
1999: GZ Tau; Paul B Rothman
Biologic functions of the IFN-gamma receptors.
Allergy 1999;54(12):1233-51.
1999: PY Pan; Paul B Rothman
IL-4 receptor mutations.
Current opinion in immunology 1999;11(6):615-20.
1999: M Dorsch; Nika N Danial; Paul B Rothman; Stephen P Goff
A thrombopoietin receptor mutant deficient in Jak-STAT activation mediates proliferation but not differentiation in UT-7 cells.
Blood 1999;94(8):2676-85.
1999: Miera B Harris; Chung-Che Chang; Michael Berton; Nika N Danial; J Zhang; D Kuehner; B H Ye; M Kvatyuk; Pier Paolo Pandolfi; Giorgio Cattoretti; Riccardo Dalla-Favera; Paul B Rothman
Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching.
Molecular and cellular biology 1999;19(10):7264-75.
1999: Julie A Losman; X Peter Chen; D Hilton; Paul B Rothman
Cutting edge: SOCS-1 is a potent inhibitor of IL-4 signal transduction.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(7):3770-4.
1999: Julie A Losman; X Peter Chen; Hong Jiang; PY Pan; Masaki Kashiwada; CC Giallourakis; Simone Cowan; K Foltenyi; Paul B Rothman
IL-4 signaling is regulated through the recruitment of phosphatases, kinases, and SOCS proteins to the receptor complex.
Cold Spring Harbor symposia on quantitative biology 1999;64():405-16.
1998: Arnob Banerjee; Paul B Rothman
IL-7 reconstitutes multiple aspects of v-Abl-mediated signaling.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(9):4611-7.
1998: Nika N Danial; Julie A Losman; T Lu; N Yip; K Krishnan; John Krolewski; Stephen P Goff; J Y Wang; Paul B Rothman
Direct interaction of Jak1 and v-Abl is required for v-Abl-induced activation of STATs and proliferation.
Molecular and cellular biology 1998;18(11):6795-804.
1998: Rachel L Miller; TM Eppinger; D McConnell; Charlotte Cunningham-Rundles; Paul B Rothman
Analysis of cytokine signaling in patients with extrinsic asthma and hyperimmunoglobulin E.
The Journal of allergy and clinical immunology 1998;102(3):503-11.
1998: B Lu; C Ebensperger; Z Dembic; Y Wang; M Kvatyuk; T Lu; Robert L Coffman; S Pestka; Paul B Rothman
Targeted disruption of the interferon-gamma receptor 2 gene results in severe immune defects in mice.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(14):8233-8.
1997: M Dorsch; Pang-Dian Fan; Nika N Danial; Paul B Rothman; Stephen P Goff
The thrombopoietin receptor can mediate proliferation without activation of the Jak-STAT pathway.
The Journal of experimental medicine 1997;186(12):1947-55.
1997: S K Chai; Gwen L Nichols; Paul B Rothman
Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(10):4720-8.
1997: V P Pham; Paul B Rothman; K M Gottesdiener
Binding of trans-acting factors to the double-stranded variant surface glycoprotein (VSG) expression site promoter of Trypanosoma brucei.
Molecular and biochemical parasitology 1997;89(1):11-23.
1997: B Lu; M Reichel; D A Fisher; J F Smith; Paul B Rothman
Identification of a STAT6 domain required for IL-4-induced activation of transcription.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(3):1255-64.
1997: M Reichel; Brad H Nelson; Philip D Greenberg; Paul B Rothman
The IL-4 receptor alpha-chain cytoplasmic domain is sufficient for activation of JAK-1 and STAT6 and the induction of IL-4-specific gene expression.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(12):5860-7.
1997: B H Ye; Giorgio Cattoretti; Qiong Shen; J Zhang; N Hawe; R de Waard; Conrad Leung; M Nouri-Shirazi; Attilio Orazi; Raju S K Chaganti; Paul B Rothman; A M Stall; Pier Paolo Pandolfi; Riccardo Dalla-Favera
The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation.
Nature genetics 1997;16(2):161-70.
1996: John J Ryan; L J McReynolds; Achsah D Keegan; L H Wang; Evan Garfein; Paul B Rothman; Keats Nelms; William Paul
Growth and gene expression are predominantly controlled by distinct regions of the human IL-4 receptor.
Immunity 1996;4(2):123-32.
1995: Nika N Danial; Alessandra B Pernis; Paul B Rothman
Jak-STAT signaling induced by the v-abl oncogene.
Science (New York, N.Y.) 1995;269(5232):1875-7.
1995: Alessandra B Pernis; B Witthuhn; Achsah D Keegan; Keats Nelms; Evan Garfein; J N Ihle; William Paul; JH Pierce; Paul B Rothman
Interleukin 4 signals through two related pathways.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(17):7971-5.
1995: Alessandra B Pernis; Sanjay Gupta; Kenneth Gollob; Evan Garfein; R L Coffman; Christian Schindler; Paul B Rothman
Lack of interferon gamma receptor beta chain and the prevention of interferon gamma signaling in TH1 cells.
Science (New York, N.Y.) 1995;269(5221):245-7.
1995: Alessandra B Pernis; Sanjay Gupta; J Yopp; Evan Garfein; H Kashleva; Christian Schindler; Paul B Rothman
Gamma chain-associated cytokine receptors signal through distinct transducing factors.
The Journal of biological chemistry 1995;270(24):14517-22.
1995: J Kim; R Reeves; Paul B Rothman; Mark Boothby
The non-histone chromosomal protein HMG-I(Y) contributes to repression of the immunoglobulin heavy chain germ-line epsilon RNA promoter.
European journal of immunology 1995;25(3):798-808.
1994: Paul B Rothman; B Kreider; M Azam; D Levy; U Wegenka; A Eilers; Thomas Decker; F Horn; H Kashleva; J Ihle
Cytokines and growth factors signal through tyrosine phosphorylation of a family of related transcription factors.
Immunity 1994;1(6):457-68.
1994: L Xu; Paul B Rothman
IFN-gamma represses epsilon germline transcription and subsequently down-regulates switch recombination to epsilon.
International immunology 1994;6(4):515-21.
1994: S C Li; Paul B Rothman; J Zhang; C Chan; D Hirsh; F W Alt
Expression of I mu-C gamma hybrid germline transcripts subsequent to immunoglobulin heavy chain class switching.
International immunology 1994;6(4):491-7.
1994: L R Covey; A M Cleary; Michael Yellin; R Ware; G Sullivan; J Belko; M Parker; Paul B Rothman; Leonard Chess; S Lederman
Isolation of cDNAs encoding T-BAM, a surface glycoprotein on CD4+ T cells mediating contact-dependent helper function for B cells: identity with the CD40-ligand.
Molecular immunology 1994;31(6):471-84.
1994: Christian Schindler; H Kashleva; Alessandra B Pernis; R Pine; Paul B Rothman
STF-IL-4: a novel IL-4-induced signal transducing factor.
The EMBO journal 1994;13(6):1350-6.
1994: S Lederman; Michael Yellin; A M Cleary; Alessandra B Pernis; Giorgio Inghirami; L E Cohn; L R Covey; J J Lee; Paul B Rothman; Leonard Chess
T-BAM/CD40-L on helper T lymphocytes augments lymphokine-induced B cell Ig isotype switch recombination and rescues B cells from programmed cell death.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(5):2163-71.
1994: Andrea Bottaro; R Lansford; L Xu; J Zhang; Paul B Rothman; F W Alt
S region transcription per se promotes basal IgE class switch recombination but additional factors regulate the efficiency of the process.
The EMBO journal 1994;13(3):665-74.
1993: Paul B Rothman
Interleukin 4 targeting of immunoglobulin heavy chain class-switch recombination.
Research in immunology 1993;144(8):579-83.
1993: L Xu; B Gorham; S C Li; Andrea Bottaro; F W Alt; Paul B Rothman
Replacement of germ-line epsilon promoter by gene targeting alters control of immunoglobulin heavy chain class switching.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(8):3705-9.
1993: T M McIntyre; D R Klinman; Paul B Rothman; M Lugo; J R Dasch; James J Mond; Clifford M Snapper
Transforming growth factor beta 1 selectivity stimulates immunoglobulin G2b secretion by lipopolysaccharide-activated murine B cells.
The Journal of experimental medicine 1993;177(4):1031-7.
1993: Robert L Coffman; D A Lebman; Paul B Rothman
Mechanism and regulation of immunoglobulin isotype switching.
Advances in immunology 1993;54():229-70.
1992: C L Schultz; Paul B Rothman; R Kühn; Marilyn R Kehry; Werner Muller; K Rajewsky; F Alt; Robert L Coffman
T helper cell membranes promote IL-4-independent expression of germ-line C gamma 1 transcripts in B cells.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(1):60-4.
1991: Paul B Rothman; S C Li; B Gorham; L Glimcher; F Alt; Mark Boothby
Identification of a conserved lipopolysaccharide-plus-interleukin-4-responsive element located at the promoter of germ line epsilon transcripts.
Molecular and cellular biology 1991;11(11):5551-61.
1991: S C Li; Paul B Rothman; Mark Boothby; P Ferrier; L Glimcher; F W Alt
Control of immunoglobulin heavy chain constant region gene expression.
Advances in experimental medicine and biology 1991;292():245-51.
1990: G D Yancopoulos; E M Oltz; GA Rathbun; J E Berman; R K Smith; R D Lansford; Paul B Rothman; A Okada; G Lee; M Morrow
Isolation of coordinately regulated genes that are expressed in discrete stages of B-cell development.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(15):5759-63.
1990: Paul B Rothman; Y Y Chen; S Lutzker; S C Li; V Stewart; R Coffman; F W Alt
Structure and expression of germ line immunoglobulin heavy-chain epsilon transcripts: interleukin-4 plus lipopolysaccharide-directed switching to C epsilon.
Molecular and cellular biology 1990;10(4):1672-9.
1990: Paul B Rothman; S Lutzker; B Gorham; V Stewart; R Coffman; F W Alt
Structure and expression of germline immunoglobulin gamma 3 heavy chain gene transcripts: implications for mitogen and lymphokine directed class-switching.
International immunology 1990;2(7):621-7.
1988: Paul B Rothman; S Lutzker; W Cook; R Coffman; F W Alt
Mitogen plus interleukin 4 induction of C epsilon transcripts in B lymphoid cells.
The Journal of experimental medicine 1988;168(6):2385-9.
1988: S Lutzker; Paul B Rothman; R Pollock; R Coffman; F W Alt
Mitogen- and IL-4-regulated expression of germ-line Ig gamma 2b transcripts: evidence for directed heavy chain class switching.
Cell 1988;53(2):177-84.
1988: F W Alt; P Ferrier; Barbara A Malynn; S Lutzker; Paul B Rothman; J Berman; K Blackwell; S Mellis; R Pollock; A Furley
Control of recombination events during lymphocyte differentiation. Heavy chain variable region gene assembly and heavy chain class switching.
Annals of the New York Academy of Sciences 1988;546():9-24.
1982: Y Thomas; L Rogozinski; Paul B Rothman; LeRoy E Rabbani; S Andrews; O H Irigoyen; Leonard Chess
Further dissection of the functional heterogeneity within the OKT4+ and OKT8+ human T cell subsets.
Journal of clinical immunology 1982;2(3 Suppl):8S-14S.