FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Richard Rothman

Research Profile

Living Beings

Chemicals & Drugs

Co-author Network

Publications

TOP 3
Malliga R Iyer; Arthur E Jacobson; Christina M Dersch; Richard B Rothman; Kenner C Rice
Probes for narcotic receptor mediated phenomena. 47.(1) Novel C4a- and N-substituted-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols.
Michael H Baumann; Simon D Brandt; Nicholas Cozzi; Steven R Goldberg; Alexander F Hoffman; Marion Holy; Kurt R Lehner; Carl R Lupica; John S Partilla; Richard B Rothman; Harald H Sitte; Srihari R Tella; Eric B Thorndike; Charles W Schindler
Powerful cocaine-like actions of 3,4-Methylenedioxypyrovalerone (MDPV), a principal constituent of psychoactive 'bath salts' products.
Nicholas Cozzi; Paul Freeman Daley; John S Partilla; Richard B Rothman; Harald H Sitte; Andreas Tulzer; Simon D Brandt; Michael H Baumann
Pharmacological examination of trifluoromethyl ring-substituted methcathinone analogs.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Richard Rothman (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Malliga R Iyer; Arthur E Jacobson; Christina M Dersch; Richard B Rothman; Kenner C Rice
Probes for narcotic receptor mediated phenomena. 47.(1) Novel C4a- and N-substituted-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols.
Bioorganic & medicinal chemistry 2013;21(11):3298-309.
2013: Michael H Baumann; Simon D Brandt; Nicholas Cozzi; Steven R Goldberg; Alexander F Hoffman; Marion Holy; Kurt R Lehner; Carl R Lupica; John S Partilla; Richard B Rothman; Harald H Sitte; Srihari R Tella; Eric B Thorndike; Charles W Schindler
Powerful cocaine-like actions of 3,4-Methylenedioxypyrovalerone (MDPV), a principal constituent of psychoactive 'bath salts' products.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2013;38(4):552-62.
2013: Nicholas Cozzi; Paul Freeman Daley; John S Partilla; Richard B Rothman; Harald H Sitte; Andreas Tulzer; Simon D Brandt; Michael H Baumann
Pharmacological examination of trifluoromethyl ring-substituted methcathinone analogs.
European journal of pharmacology 2013;699(1-3):180-7.
2012: Fuying Li; Richard B Rothman; Jason A Deck; Christina M Dersch; Jeffrey R Deschamps; Arthur E Jacobson; Kenner C Rice
Probes for narcotic receptor mediated phenomena. 46. N-substituted-2,3,4,9,10,10a-hexahydro-1H-1,4a-(epiminoethano)phenanthren-6- and 8-ols - carbocyclic relatives of f-oxide-bridged phenylmorphans.
European journal of medicinal chemistry 2012;58():557-67.
2012: Subramaniam Ananthan; Edward J Bilsky; Christina M Dersch; Denise Giuvelis; Nicholas McGlinchey; Surendra K Saini; Heng Xu; Richard B Rothman
14-Alkoxy- and 14-acyloxypyridomorphinans: μ agonist/δ antagonist opioid analgesics with diminished tolerance and dependence side effects.
Journal of medicinal chemistry 2012;55(19):8350-63.
2012: Kasper Severinsen; Katrine A Vinberg; Ove Wiborg; Bruce E Blough; Heidi Koldsø; Johan F Kraft; John S Partilla; Richard B Rothman; Birgit Schiøtt; Steffen Sinning
Binding of the amphetamine-like 1-phenyl-piperazine to monoamine transporters.
ACS chemical neuroscience 2012;3(9):693-705.
2012: Malliga R Iyer; Arthur E Jacobson; Yong-Sok Lee; Christina M Dersch; Jeffrey R Deschamps; Richard B Rothman; Kenner C Rice
Probes for narcotic receptor mediated phenomena. 44. Synthesis of an N-substituted 4-hydroxy-5-(3-hydroxyphenyl)morphan with high affinity and selective μ-antagonist activity.
European journal of medicinal chemistry 2012;50():44-54.
2012: Richard B Rothman; Michael H Baumann; Catrissa Lightfoot-Siordia; John S Partilla; Bruce E Blough
Studies of the biogenic amine transporters. 14. Identification of low-efficacy "partial" substrates for the biogenic amine transporters.
The Journal of pharmacology and experimental therapeutics 2012;341(1):251-62.
2012: Michael H Baumann; Simon D Brandt; Mario A Ayestas; Paul Freeman Daley; John S Partilla; Richard B Rothman; Arnold E Ruoho; Alexander T Shulgin; Jacqueline R Sink; Nicholas Cozzi
The designer methcathinone analogs, mephedrone and methylone, are substrates for monoamine transporters in brain tissue.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2012;37(5):1192-203.
2011: Feng Li; Richard B Rothman; Kejun Cheng; Jason A Deck; Christina M Dersch; Jeffrey Deschamps; John E Folk; Arthur E Jacobson; Muneaki Kurimura; Kenner C Rice
Probes for narcotic receptor mediated phenomena. 43. Synthesis of the ortho-a and para-a, and improved synthesis and optical resolution of the ortho-b and para-b oxide-bridged phenylmorphans: compounds with moderate to low opioid-receptor affinity.
Bioorganic & medicinal chemistry 2011;19(14):4330-7.
2011: Jin-Hee Kim; Jeffrey Deschamps; Richard B Rothman; Christina M Dersch; John E Folk; Kejun Cheng; Arthur E Jacobson; Kenner C Rice
Probes for narcotic receptor mediated phenomena. Part 42: synthesis and in vitro pharmacological characterization of the N-methyl and N-phenethyl analogues of the racemic ortho-c and para-c oxide-bridged phenylmorphans.
Bioorganic & medicinal chemistry 2011;19(11):3434-43.
2011: Anthony Lozama; Christopher W Cunningham; Michael J Caspers; Justin T Douglas; Christina M Dersch; Richard B Rothman; Thomas E Prisinzano
Opioid receptor probes derived from cycloaddition of the hallucinogen natural product salvinorin A.
Journal of natural products 2011;74(4):718-26.
2011: Michael H Baumann; Robert D Clark; William L Woolverton; Sunmee Wee; Bruce E Blough; Richard B Rothman
In vivo effects of amphetamine analogs reveal evidence for serotonergic inhibition of mesolimbic dopamine transmission in the rat.
The Journal of pharmacology and experimental therapeutics 2011;337(1):218-25.
2011: Michael H Baumann; Zakia Williams; Dorota Zolkowska; Richard B Rothman
Serotonin (5-HT) precursor loading with 5-hydroxy-l-tryptophan (5-HTP) reduces locomotor activation produced by (+)-amphetamine in the rat.
Drug and alcohol dependence 2011;114(2-3):147-52.
2011: Kejun Cheng; Yong-Sok Lee; Richard B Rothman; Christina M Dersch; Ross W Bittman; Arthur E Jacobson; Kenner C Rice
Probes for narcotic receptor mediated phenomena. 41. Unusual inverse μ-agonists and potent μ-opioid antagonists by modification of the N-substituent in enantiomeric 5-(3-hydroxyphenyl)morphans.
Journal of medicinal chemistry 2011;54(4):957-69.
2011: Richard B Rothman; Jean Lud Cadet; Christina M Dersch; Michael T McCoy; Elin Lehrmann; Kevin G Becker; Michael Bader; Natalia Alenina; Michael H Baumann
Altered gene expression in pulmonary tissue of tryptophan hydroxylase-1 knockout mice: implications for pulmonary arterial hypertension.
PloS one 2011;6(3):e17735.
2010: Richard B Rothman; Michael H Baumann; Bruce E Blough; Arthur E Jacobson; Kenner C Rice; John S Partilla
Evidence for noncompetitive modulation of substrate-induced serotonin release.
Synapse (New York, N.Y.) 2010;64(11):862-9.
2010: Elliott J Sally; Heng Xu; Christina M Dersch; Ling-Wei Hsin; Li-Te Chang; Thomas E Prisinzano; Denise S Simpson; Denise Giuvelis; Kenner C Rice; Arthur E Jacobson; Kejun Cheng; Edward J Bilsky; Richard B Rothman
Identification of a novel "almost neutral" micro-opioid receptor antagonist in CHO cells expressing the cloned human mu-opioid receptor.
Synapse (New York, N.Y.) 2010;64(4):280-8.
2010: Malliga R Iyer; Yong-Sok Lee; Jeffrey Deschamps; Richard B Rothman; Christina M Dersch; Arthur E Jacobson; Kenner C Rice
Probes for narcotic receptor mediated phenomena. 40. N-substituted cis-4a-ethyl-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-8-ols.
Bioorganic & medicinal chemistry 2010;18(1):91-9.
2009: Yi Zhang; Yong-Sok Lee; Richard B Rothman; Christina M Dersch; Jeffrey Deschamps; Arthur E Jacobson; Kenner C Rice
Probes for narcotic receptor mediated phenomena. 39. Enantiomeric N-substituted benzofuro[2,3-c]pyridin-6-ols: synthesis and topological relationship to oxide-bridged phenylmorphans.
Journal of medicinal chemistry 2009;52(23):7570-9.
2009: Michael H Baumann; Dorota Zolkowska; Insook Kim; Karl B Scheidweiler; Richard B Rothman; Marilyn A Huestis
Effects of dose and route of administration on pharmacokinetics of (+ or -)-3,4-methylenedioxymethamphetamine in the rat.
Drug metabolism and disposition: the biological fate of chemicals 2009;37(11):2163-70.
2009: Richard B Rothman; Michael H Baumann
Appetite suppressants, cardiac valve disease and combination pharmacotherapy.
American journal of therapeutics 2009;16(4):354-64.
2009: Richard B Rothman; Michael H Baumann
Serotonergic drugs and valvular heart disease.
Expert opinion on drug safety 2009;8(3):317-29.
2009: Richard B Rothman; Christina M Dersch; Subramaniam Ananthan; John S Partilla
Studies of the biogenic amine transporters. 13. Identification of "agonist" and "antagonist" allosteric modulators of amphetamine-induced dopamine release.
The Journal of pharmacology and experimental therapeutics 2009;329(2):718-28.
2009: Dorota Zolkowska; Raka Jain; Richard B Rothman; John S Partilla; Bryan L Roth; Vincent Setola; Thomas E Prisinzano; Michael H Baumann
Evidence for the involvement of dopamine transporters in behavioral stimulant effects of modafinil.
The Journal of pharmacology and experimental therapeutics 2009;329(2):738-46.
2009: Michael H Baumann; Richard B Rothman
Neural and cardiac toxicities associated with 3,4-methylenedioxymethamphetamine (MDMA).
International review of neurobiology 2009;88():257-96.
2008: Richard B Rothman; Dorota Zolkowska; Michael H Baumann
Serotonin (5-HT) transporter ligands affect plasma 5-HT in rats.
Annals of the New York Academy of Sciences 2008;1139():268-84.
2008: Heng Xu; Xiaoying Wang; John S Partilla; Kristen Bishop-Mathis; tova benaderet; Christina M Dersch; Denise S Simpson; Thomas E Prisinzano; Richard B Rothman
Differential effects of opioid agonists on G protein expression in CHO cells expressing cloned human opioid receptors.
Brain research bulletin 2008;77(1):49-54.
2008: Josef Zezula; Lisa Singer; Anna K Przybył; Akihiro Hashimoto; Christina M Dersch; Richard B Rothman; Jeffrey Deschamps; Yong-Sok Lee; Arthur E Jacobson; Kenner C Rice
Synthesis and pharmacological effects of the enantiomers of the N-phenethyl analogues of the ortho and para e- and f-oxide-bridged phenylmorphans.
Organic & biomolecular chemistry 2008;6(16):2868-83.
2008: John M Rutherford; Jia Bei Wang; Heng Xu; Christina M Dersch; John S Partilla; Kenner C Rice; Richard B Rothman
Evidence for a mu-delta opioid receptor complex in CHO cells co-expressing mu and delta opioid peptide receptors.
Peptides 2008;29(8):1424-31.
2008: Michael H Baumann; Robert D Clark; Richard B Rothman
Locomotor stimulation produced by 3,4-methylenedioxymethamphetamine (MDMA) is correlated with dialysate levels of serotonin and dopamine in rat brain.
Pharmacology, biochemistry, and behavior 2008;90(2):208-17.
2008: Joseph J Pariser; John S Partilla; Christina M Dersch; Subramaniam Ananthan; Richard B Rothman
Studies of the biogenic amine transporters. 12. Identification of novel partial inhibitors of amphetamine-induced dopamine release.
The Journal of pharmacology and experimental therapeutics 2008;326(1):286-95.
2008: Kevin Tidgewell; Chad E Groer; Wayne W Harding; Anthony Lozama; Matthew Schmidt; Alfred Marquam; Jessica Hiemstra; John S Partilla; Christina M Dersch; Richard B Rothman; Laura M Bohn; Thomas E Prisinzano
Herkinorin analogues with differential beta-arrestin-2 interactions.
Journal of medicinal chemistry 2008;51(8):2421-31.
2008: Michael H Baumann; Robert D Clark; Frederick H Franken; J J Rutter; Richard B Rothman
Tolerance to 3,4-methylenedioxymethamphetamine in rats exposed to single high-dose binges.
Neuroscience 2008;152(3):773-84.
2008: Dorota Zolkowska; Michael H Baumann; Richard B Rothman
Chronic fenfluramine administration increases plasma serotonin (5-hydroxytryptamine) to nontoxic levels.
The Journal of pharmacology and experimental therapeutics 2008;324(2):791-7.
2008: Richard B Rothman; Bruce E Blough; Michael H Baumann
Dopamine/serotonin releasers as medications for stimulant addictions.
Progress in brain research 2008;172():385-406.
2008: Richard B Rothman; Michael H Baumann; Thomas E Prisinzano; Amy Hauck Newman
Dopamine transport inhibitors based on GBR12909 and benztropine as potential medications to treat cocaine addiction.
Biochemical pharmacology 2008;75(1):2-16.
2007: Kenneth G Holden; Kevin Tidgewell; Alfred Marquam; Richard B Rothman; Hernán Navarro; Thomas E Prisinzano
Synthetic studies of neoclerodane diterpenes from Salvia divinorum: exploration of the 1-position.
Bioorganic & medicinal chemistry letters 2007;17(22):6111-5.
2007: Xiaoying Wang; Michael H Baumann; Christina M Dersch; Richard B Rothman
Restoration of 3,4-methylenedioxymethamphetamine-induced 5-HT depletion by the administration of L-5-hydroxytryptophan.
Neuroscience 2007;148(1):212-20.
2007: Anne-Cécile Hiebel; Yong-Sok Lee; Edward J Bilsky; Denise Giuvelis; Jeffrey Deschamps; Damon Parrish; Mario D Aceto; Everette L May; Louis S Harris; Andrew Coop; Christina M Dersch; John S Partilla; Richard B Rothman; Kejun Cheng; Arthur E Jacobson; Kenner C Rice
Probes for narcotic receptor mediated phenomena. 34. Synthesis and structure-activity relationships of a potent mu-agonist delta-antagonist and an exceedingly potent antinociceptive in the enantiomeric C9-substituted 5-(3-hydroxyphenyl)-N-phenylethylmorphan series.
Journal of medicinal chemistry 2007;50(16):3765-76.
2007: Denise S Simpson; Peter L Katavic; Anthony Lozama; Wayne W Harding; Damon Parrish; Jeffrey Deschamps; Christina M Dersch; John S Partilla; Richard B Rothman; Hernan Navarro; Thomas E Prisinzano
Synthetic studies of neoclerodane diterpenes from Salvia divinorum: preparation and opioid receptor activity of salvinicin analogues.
Journal of medicinal chemistry 2007;50(15):3596-603.
2007: Kejun Cheng; In Jong Kim; Mei-Jing Lee; Steven A Adah; Tyler J Raymond; Edward J Bilsky; Mario D Aceto; Everette L May; Louis S Harris; Andrew Coop; Christina M Dersch; Richard B Rothman; Arthur E Jacobson; Kenner C Rice
Opioid ligands with mixed properties from substituted enantiomeric N-phenethyl-5-phenylmorphans. Synthesis of a micro-agonist delta-antagonist and delta-inverse agonists.
Organic & biomolecular chemistry 2007;5(8):1177-90.
2007: Heng Xu; John S Partilla; Xiaoying Wang; John M Rutherford; Kevin Tidgewell; Thomas E Prisinzano; Laura M Bohn; Richard B Rothman
A comparison of noninternalizing (herkinorin) and internalizing (DAMGO) mu-opioid agonists on cellular markers related to opioid tolerance and dependence.
Synapse (New York, N.Y.) 2007;61(3):166-75.
2007: C E Groer; Kevin Tidgewell; R A Moyer; Wayne W Harding; Richard B Rothman; Thomas E Prisinzano; Laura M Bohn
An opioid agonist that does not induce mu-opioid receptor--arrestin interactions or receptor internalization.
Molecular pharmacology 2007;71(2):549-57.
2007: S Stevens Negus; Nancy K Mello; Bruce E Blough; Michael H Baumann; Richard B Rothman
Monoamine releasers with varying selectivity for dopamine/norepinephrine versus serotonin release as candidate "agonist" medications for cocaine dependence: studies in assays of cocaine discrimination and cocaine self-administration in rhesus monkeys.
The Journal of pharmacology and experimental therapeutics 2007;320(2):627-36.
2007: Richard B Rothman; Daniel L Murphy; Heng Xu; Jonathan A Godin; Christina M Dersch; John S Partilla; Kevin Tidgewell; Matthew Schmidt; Thomas E Prisinzano
Salvinorin A: allosteric interactions at the mu-opioid receptor.
The Journal of pharmacology and experimental therapeutics 2007;320(2):801-10.
2007: Kathleen M Gilbert; Terrence L Boos; Christina M Dersch; Elisabeth Greiner; Arthur E Jacobson; David Lewis; Dorota Matecka; Thomas E Prisinzano; Ying Zhang; Richard B Rothman; Kenner C Rice; Carol A Venanzi
DAT/SERT selectivity of flexible GBR 12909 analogs modeled using 3D-QSAR methods.
Bioorganic & medicinal chemistry 2007;15(2):1146-59.
2007: Udi E Ghitza; Richard B Rothman; David A Gorelick; Jack E Henningfield; Michael H Baumann
Serotonergic responsiveness in human cocaine users.
Drug and alcohol dependence 2007;86(2-3):207-13.
2007: Richard B Rothman; Bruce E Blough; Michael H Baumann
Dual dopamine/serotonin releasers as potential medications for stimulant and alcohol addictions.
The AAPS journal 2007;9(1):E1-10.
2007: Michael H Baumann; Xiaoying Wang; Richard B Rothman
3,4-Methylenedioxymethamphetamine (MDMA) neurotoxicity in rats: a reappraisal of past and present findings.
Psychopharmacology 2007;189(4):407-24.
2006: Richard B Rothman; Bruce E Blough; Michael H Baumann
Dual dopamine-5-HT releasers: potential treatment agents for cocaine addiction.
Trends in pharmacological sciences 2006;27(12):612-8.
2006: John S Partilla; Allison G Dempsey; Ameet S Nagpal; Bruce E Blough; Michael H Baumann; Richard B Rothman
Interaction of amphetamines and related compounds at the vesicular monoamine transporter.
The Journal of pharmacology and experimental therapeutics 2006;319(1):237-46.
2006: Richard B Rothman; Michael H Baumann
Balance between dopamine and serotonin release modulates behavioral effects of amphetamine-type drugs.
Annals of the New York Academy of Sciences 2006;1074():245-60.
2006: Dorota Zolkowska; Richard B Rothman; Michael H Baumann
Amphetamine analogs increase plasma serotonin: implications for cardiac and pulmonary disease.
The Journal of pharmacology and experimental therapeutics 2006;318(2):604-10.
2006: Santosh S Kulkarni; Barbara Nightingale; Christina M Dersch; Richard B Rothman; Amy Hauck Newman
Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists.
Bioorganic & medicinal chemistry letters 2006;16(13):3371-5.
2006: Wayne W Harding; Matthew Schmidt; Kevin Tidgewell; Pavitra Kannan; Kenneth G Holden; Christina M Dersch; Richard B Rothman; Thomas E Prisinzano
Synthetic studies of neoclerodane diterpenes from Salvia divinorum: selective modification of the furan ring.
Bioorganic & medicinal chemistry letters 2006;16(12):3170-4.
2006: Kevin Tidgewell; Wayne W Harding; Anthony Lozama; Howard Cobb; Kushal Shah; Pavitra Kannan; Christina M Dersch; Damon Parrish; Jeffrey Deschamps; Richard B Rothman; Thomas E Prisinzano
Synthesis of salvinorin A analogues as opioid receptor probes.
Journal of natural products 2006;69(6):914-8.
2006: Terrence L Boos; Elisabeth Greiner; W Jason Calhoun; Thomas E Prisinzano; Barbara Nightingale; Christina M Dersch; Richard B Rothman; Arthur E Jacobson; Kenner C Rice
Structure-activity relationships of substituted N-benzyl piperidines in the GBR series: Synthesis of 4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(2-trifluoromethylbenzyl)piperidine, an allosteric modulator of the serotonin transporter.
Bioorganic & medicinal chemistry 2006;14(11):3967-73.
2006: Xiaoying Wang; Heng Xu; Richard B Rothman
Regulation of the rat brain endothelin system by endogenous beta-endorphin.
Peptides 2006;27(4):769-74.
2006: Elisabeth Greiner; Terrence L Boos; Thomas E Prisinzano; Maria G De Martino; Brian Zeglis; Christina M Dersch; Jamila Marcus; John S Partilla; Richard B Rothman; Arthur E Jacobson; Kenner C Rice
Design and synthesis of promiscuous high-affinity monoamine transporter ligands: unraveling transporter selectivity.
Journal of medicinal chemistry 2006;49(5):1766-72.
2006: Richard B Rothman; Michael H Baumann
Therapeutic potential of monoamine transporter substrates.
Current topics in medicinal chemistry 2006;6(17):1845-59.
2006: Wayne W Harding; Matthew Schmidt; Kevin Tidgewell; Pavitra Kannan; Kenneth G Holden; Brian Gilmour; Hernan Navarro; Richard B Rothman; Thomas E Prisinzano
Synthetic studies of neoclerodane diterpenes from Salvia divinorum: semisynthesis of salvinicins A and B and other chemical transformations of salvinorin A.
Journal of natural products 2006;69(1):107-12.
2005: Richard B Rothman; Michael H Baumann
Targeted screening for biogenic amine transporters: potential applications for natural products.
Life sciences 2005;78(5):512-8.
2005: Heng Xu; Xiaoying Wang; Darin Zimmerman; Emily Boja; Jia Bei Wang; Edward J Bilsky; Richard B Rothman
Chronic morphine up-regulates G alpha12 and cytoskeletal proteins in Chinese hamster ovary cells expressing the cloned mu opioid receptor.
The Journal of pharmacology and experimental therapeutics 2005;315(1):248-55.
2005: Xiaoying Wang; Michael H Baumann; Heng Xu; Marisela Morales; Richard B Rothman
(+/-)-3,4-Methylenedioxymethamphetamine administration to rats does not decrease levels of the serotonin transporter protein or alter its distribution between endosomes and the plasma membrane.
The Journal of pharmacology and experimental therapeutics 2005;314(3):1002-12.
2005: Barbara Nightingale; Christina M Dersch; Terrence L Boos; Elisabeth Greiner; William J Calhoun; Arthur E Jacobson; Kenner C Rice; Richard B Rothman
Studies of the biogenic amine transporters. XI. Identification of a 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR12909) analog that allosterically modulates the serotonin transporter.
The Journal of pharmacology and experimental therapeutics 2005;314(2):906-15.
2005: Wayne W Harding; Kevin Tidgewell; Nathan Byrd; Howard Cobb; Christina M Dersch; Eduardo R Butelman; Richard B Rothman; Thomas E Prisinzano
Neoclerodane diterpenes as a novel scaffold for mu opioid receptor ligands.
Journal of medicinal chemistry 2005;48(15):4765-71.
2005: Wayne W Harding; Kevin Tidgewell; Matthew Schmidt; Kushal Shah; Christina M Dersch; John Snyder; Damon Parrish; Jeffrey Deschamps; Richard B Rothman; Thomas E Prisinzano
Salvinicins A and B, new neoclerodane diterpenes from Salvia divinorum.
Organic letters 2005;7(14):3017-20.
2005: Richard B Rothman; Bruce E Blough; William L Woolverton; Karen G Anderson; S Stevens Negus; Nancy K Mello; Bryan L Roth; Michael H Baumann
Development of a rationally designed, low abuse potential, biogenic amine releaser that suppresses cocaine self-administration.
The Journal of pharmacology and experimental therapeutics 2005;313(3):1361-9.
2005: Sunmee Wee; Karen G Anderson; Michael H Baumann; Richard B Rothman; Bruce E Blough; William L Woolverton
Relationship between the serotonergic activity and reinforcing effects of a series of amphetamine analogs.
The Journal of pharmacology and experimental therapeutics 2005;313(2):848-54.
2005: Michael H Baumann; Robert D Clark; Allison G Budzynski; John S Partilla; Bruce E Blough; Richard B Rothman
N-substituted piperazines abused by humans mimic the molecular mechanism of 3,4-methylenedioxymethamphetamine (MDMA, or 'Ecstasy').
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2005;30(3):550-60.
2004: Michael H Baumann; Robert D Clark; Allison G Budzynski; John S Partilla; Bruce E Blough; Richard B Rothman
Effects of "Legal X" piperazine analogs on dopamine and serotonin release in rat brain.
Annals of the New York Academy of Sciences 2004;1025():189-97.
2004: Richard B Rothman; Subramaniam Jayanthi; Jean Lud Cadet; Xiaoying Wang; Christina M Dersch; Michael H Baumann
Substituted amphetamines that produce long-term serotonin depletion in rat brain ("neurotoxicity") do not decrease serotonin transporter protein expression.
Annals of the New York Academy of Sciences 2004;1025():151-61.
2004: Xiaoying Wang; Michael H Baumann; Heng Xu; Richard B Rothman
3,4-methylenedioxymethamphetamine (MDMA) administration to rats decreases brain tissue serotonin but not serotonin transporter protein and glial fibrillary acidic protein.
Synapse (New York, N.Y.) 2004;53(4):240-8.
2004: Ayon Nandi; Christina M Dersch; Manish Kulshrestha; Subramaniam Ananthan; Richard B Rothman
Identification and characterization of a novel allosteric modulator (SoRI-6238) of the serotonin transporter.
Synapse (New York, N.Y.) 2004;53(3):176-83.
2004: In Jong Kim; Christina M Dersch; Richard B Rothman; Arthur E Jacobson; Kenner C Rice
A critical structural determinant of opioid receptor interaction with phenolic 5-phenylmorphans.
Bioorganic & medicinal chemistry 2004;12(16):4543-50.
2004: Heng Xu; Xiaoying Wang; Jun Wang; Richard B Rothman
Opioid peptide receptor studies. 17. Attenuation of chronic morphine effects after antisense oligodeoxynucleotide knock-down of RGS9 protein in cells expressing the cloned Mu opioid receptor.
Synapse (New York, N.Y.) 2004;52(3):209-17.
2004: Han Yu; In Jong Kim; John E Folk; Xinrong Tian; Richard B Rothman; Michael H Baumann; Christina M Dersch; Judith L Flippen-Anderson; Damon Parrish; Arthur E Jacobson; Kenner C Rice
Synthesis and pharmacological evaluation of 3-(3,4-dichlorophenyl)-1-indanamine derivatives as nonselective ligands for biogenic amine transporters.
Journal of medicinal chemistry 2004;47(10):2624-34.
2004: Subramaniam Ananthan; Naveen K Khare; Surendra K Saini; Lainne E Seitz; Jeffrey L Bartlett; Peg Davis; Christina M Dersch; Frank Porreca; Richard B Rothman; Edward J Bilsky
Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone].
Journal of medicinal chemistry 2004;47(6):1400-12.
2004: James B Thomas; Scott E Fix; Richard B Rothman; Wayne Mascarella; Christina M Dersch; Buddy E Cantrell; Dennis M Zimmerman; Frank carroll
Importance of phenolic address groups in opioid kappa receptor selective antagonists.
Journal of medicinal chemistry 2004;47(4):1070-3.
2004: Frank carroll; Li Zhang; Wayne Mascarella; Hernán A Navarro; Richard B Rothman; Buddy E Cantrell; Dennis M Zimmerman; James B Thomas
Discovery of the first N-substituted 4beta-methyl-5-(3-hydroxyphenyl)morphan to possess highly potent and selective opioid delta receptor antagonist activity.
Journal of medicinal chemistry 2004;47(2):281-4.
2004: Xiaoying Wang; Heng Xu; Richard B Rothman
Intracerebroventricular administration of anti-endothelin-1 IgG selectively upregulates endothelin-A and kappa opioid receptors.
Neuroscience 2004;129(3):751-6.
2004: Michael H Baumann; A B Milchanowski; Richard B Rothman
Evidence for alterations in alpha2-adrenergic receptor sensitivity in rats exposed to repeated cocaine administration.
Neuroscience 2004;125(3):683-90.
2003: Richard B Rothman; Subramaniam Jayanthi; Xiaoying Wang; Christina M Dersch; Jean Lud Cadet; Thomas E Prisinzano; Kenner C Rice; Michael H Baumann
High-dose fenfluramine administration decreases serotonin transporter binding, but not serotonin transporter protein levels, in rat forebrain.
Synapse (New York, N.Y.) 2003;50(3):233-9.
2003: In Jong Kim; Thomas Ullrich; James Janetka; M Scott Furness; Arthur E Jacobson; Richard B Rothman; Christina M Dersch; Judith L Flippen-Anderson; Clifford George; Kenner C Rice
Diaryldimethylpiperazine ligands with mu- and delta-opioid receptor affinity: Synthesis of (+)-4-[(alphaR)-alpha-(4-allyl-(2S,5S)-dimethylpiperazin-1-yl)-(3-hydroxyphenyl)methyl]-N-ethyl-N-phenylbenzamide and (-)-4-[(alphaR)-alpha-(2S,5S)-dimethylpiperazin-1-yl)-(3-hydroxyphenyl)methyl]-N-ethyl-N-phenylbenzamide.
Bioorganic & medicinal chemistry 2003;11(22):4761-8.
2003: Richard B Rothman; Michael H Baumann
Monoamine transporters and psychostimulant drugs.
European journal of pharmacology 2003;479(1-3):23-40.
2003: Richard B Rothman; Nga Vu; John S Partilla; Bryan L Roth; Sandra J Hufeisen; Beth A Compton-Toth; Jon Birkes; Richard Young; Richard A Glennon
In vitro characterization of ephedrine-related stereoisomers at biogenic amine transporters and the receptorome reveals selective actions as norepinephrine transporter substrates.
The Journal of pharmacology and experimental therapeutics 2003;307(1):138-45.
2003: Subramaniam Ananthan; Naveen K Khare; Surendra K Saini; Peg Davis; Christina M Dersch; Frank Porreca; Richard B Rothman
Novel ligands for the opioid receptors: synthesis and structure-activity relationships among 5'-aryl and 5'-heteroaryl 17-cyclopropylmethyl-4,5 alpha-epoxypyrido[2',3':6,7]morphinans.
Bioorganic & medicinal chemistry 2003;11(18):4143-54.
2003: James B Thomas; Robert N Atkinson; N Ariane Vinson; Jennifer L Catanzaro; Carin L Perretta; Scott E Fix; Wayne Mascarella; Richard B Rothman; Heng Xu; Christina M Dersch; Buddy E Cantrell; Dennis M Zimmerman; Frank carroll
Identification of (3R)-7-hydroxy-N-((1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)- 3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl)-1,2,3,4-tetrahydro- 3-isoquinolinecarboxamide as a novel potent and selective opioid kappa receptor antagonist.
Journal of medicinal chemistry 2003;46(14):3127-37.
2003: Vincent Setola; Sandra J Hufeisen; K Jane Grande-Allen; Ivan Vesely; Richard A Glennon; Bruce Blough; Richard B Rothman; Bryan L Roth
3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro.
Molecular pharmacology 2003;63(6):1223-9.
2003: Richard B Rothman; Robert D Clark; John S Partilla; Michael H Baumann
(+)-Fenfluramine and its major metabolite, (+)-norfenfluramine, are potent substrates for norepinephrine transporters.
The Journal of pharmacology and experimental therapeutics 2003;305(3):1191-9.
2003: Elisabeth Greiner; Thomas E Prisinzano; Edward M Johnson; Christina M Dersch; Jamila Marcus; John S Partilla; Richard B Rothman; Arthur E Jacobson; Kenner C Rice
Structure-activity relationship studies of highly selective inhibitors of the dopamine transporter: N-benzylpiperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine.
Journal of medicinal chemistry 2003;46(8):1465-9.
2003: David Lewis; Ying Zhang; Thomas E Prisinzano; Christina M Dersch; Richard B Rothman; Arthur E Jacobson; Kenner C Rice
Further exploration of 1-[2-[Bis-(4-fluorophenyl)methoxy]ethyl]piperazine (GBR 12909): role of N-aromatic, N-heteroaromatic, and 3-oxygenated N-phenylpropyl substituents on affinity for the dopamine and serotonin transporter.
Bioorganic & medicinal chemistry letters 2003;13(7):1385-9.
2003: Richard B Rothman; Nga Vu; Xiaoying Wang; Heng Xu
Endogenous CART peptide regulates mu opioid and serotonin 5-HT(2A) receptors.
Peptides 2003;24(3):413-7.
2003: Ling-Wei Hsin; Thomas E Prisinzano; Chavon R Wilkerson; Christina M Dersch; Robert Horel; Arthur E Jacobson; Richard B Rothman; Kenner C Rice
Synthesis and dopamine transporter affinity of chiral 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(2-hydroxypropyl)piperazines as potential cocaine abuse therapeutic agents.
Bioorganic & medicinal chemistry letters 2003;13(3):553-6.
2003: Subramaniam Ananthan; Hollis S Kezar; Surendra K Saini; Naveen K Khare; Peg Davis; Christina M Dersch; Frank Porreca; Richard B Rothman
Synthesis, opioid receptor binding, and functional activity of 5'-substituted 17-cyclopropylmethylpyrido[2',3':6,7]morphinans.
Bioorganic & medicinal chemistry letters 2003;13(3):529-32.
2003: Heng Xu; Yi-Feng Lu; Richard B Rothman
Opioid peptide receptor studies. 16. Chronic morphine alters G-protein function in cells expressing the cloned mu opioid receptor.
Synapse (New York, N.Y.) 2003;47(1):1-9.
2002: Richard B Rothman; Nga Vu; Heng Xu; Michael H Baumann; Yi-Feng Lu
Endogenous corticotropin releasing factor regulates adrenergic and opioid receptors.
Peptides 2002;23(12):2177-80.
2002: Johannes Schütz; Christina M Dersch; Robert Horel; Mariana Spetea; Martin Koch; Ruth Meditz; Elisabeth Greiner; Richard B Rothman; Helmut Schmidhammer
Synthesis and biological evaluation of 14-alkoxymorphinans. 17. Highly delta opioid receptor selective 14-alkoxy-substituted indolo- and benzofuromorphinans.
Journal of medicinal chemistry 2002;45(24):5378-83.
2002: Akihiro Hashimoto; Arthur E Jacobson; Richard B Rothman; Christina M Dersch; Clifford George; Judith L Flippen-Anderson; Kenner C Rice
Probes for narcotic receptor mediated phenomena. Part 28: new opioid antagonists from enantiomeric analogues of 5-(3-hydroxyphenyl)-N-phenylethylmorphan.
Bioorganic & medicinal chemistry 2002;10(10):3319-29.
2002: Thomas E Prisinzano; Elisabeth Greiner; Edward M Johnson; Christina M Dersch; Jamila Marcus; John S Partilla; Richard B Rothman; Arthur E Jacobson; Kenner C Rice
Piperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909): high affinity ligands for the dopamine transporter.
Journal of medicinal chemistry 2002;45(19):4371-4.
2002: Bryan L Roth; Karen Baner; Richard B Westkaemper; Daniel Siebert; Kenner C Rice; SeAnna Steinberg; Paul Ernsberger; Richard B Rothman
Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(18):11934-9.
2002: Subramaniam Ananthan; Surendra K Saini; Rashmi Khare; Sarah D Clayton; Christina M Dersch; Richard B Rothman
Identification of a novel partial inhibitor of dopamine transporter among 4-substituted 2-phenylquinazolines.
Bioorganic & medicinal chemistry letters 2002;12(16):2225-8.
2002: James B Thomas; Robert N Atkinson; Nivedita Namdev; Richard B Rothman; Kenneth M Gigstad; Scott E Fix; Wayne Mascarella; Jason P Burgess; N Ariane Vinson; Heng Xu; Christina M Dersch; Buddy E Cantrell; Dennis M Zimmerman; Frank carroll
Discovery of an opioid kappa receptor selective pure antagonist from a library of N-substituted 4beta-methyl-5-(3-hydroxyphenyl)morphans.
Journal of medicinal chemistry 2002;45(16):3524-30.
2002: Richard B Rothman; Michael H Baumann
Therapeutic and adverse actions of serotonin transporter substrates.
Pharmacology & therapeutics 2002;95(1):73-88.
2002: Richard B Rothman; Marina Katsnelson; Nga Vu; John S Partilla; Christina M Dersch; Bruce E Blough; Michael H Baumann
Interaction of the anorectic medication, phendimetrazine, and its metabolites with monoamine transporters in rat brain.
European journal of pharmacology 2002;447(1):51-7.
2002: Richard B Rothman; Bruce E Blough; Michael H Baumann
Appetite suppressants as agonist substitution therapies for stimulant dependence.
Annals of the New York Academy of Sciences 2002;965():109-26.
2002: Michael H Baumann; Jennifer M Phillips; Mario A Ayestas; Syed F Ali; Kenner C Rice; Richard B Rothman
Preclinical evaluation of GBR12909 decanoate as a long-acting medication for methamphetamine dependence.
Annals of the New York Academy of Sciences 2002;965():92-108.
2002: Michael H Baumann; Mario A Ayestas; Lawrence G Sharpe; David B Lewis; Kenner C Rice; Richard B Rothman
Persistent antagonism of methamphetamine-induced dopamine release in rats pretreated with GBR12909 decanoate.
The Journal of pharmacology and experimental therapeutics 2002;301(3):1190-7.
2002: Richard B Rothman; Frank carroll; Marisela Morales; Daniel L Rowley; Kenner C Rice; Christina M Dersch; David M Donovan
Studies of the biogenic amine transporters. 10. Characterization of a novel cocaine binding site in brain membranes prepared from dopamine transporter knockout mice.
Synapse (New York, N.Y.) 2002;44(2):94-105.
2002: Richard B Rothman; Michael H Baumann
Serotonin releasing agents. Neurochemical, therapeutic and adverse effects.
Pharmacology, biochemistry, and behavior 2002;71(4):825-36.
2002: Richard B Rothman; Christina M Dersch; Frank carroll; Subramaniam Ananthan
Studies of the biogenic amine transporters. VIII: identification of a novel partial inhibitor of dopamine uptake and dopamine transporter binding.
Synapse (New York, N.Y.) 2002;43(4):268-74.
2002: Ling-Wei Hsin; Christina M Dersch; Michael H Baumann; David Stafford; John R Glowa; Richard B Rothman; Arthur E Jacobson; Kenner C Rice
Development of long-acting dopamine transporter ligands as potential cocaine-abuse therapeutic agents: chiral hydroxyl-containing derivatives of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine.
Journal of medicinal chemistry 2002;45(6):1321-9.
2002: Han Yu; Thomas E Prisinzano; Christina M Dersch; Jamila Marcus; Richard B Rothman; Arthur E Jacobson; Kenner C Rice
Synthesis and biological activity of 8beta-substituted hydrocodone indole and hydromorphone indole derivatives.
Bioorganic & medicinal chemistry letters 2002;12(2):165-8.
2001: Ying Zhang; D B Joseph; Wayne D Bowen; Judith L Flippen-Anderson; Christina M Dersch; Richard B Rothman; Arthur E Jacobson; Kenner C Rice
Synthesis and biological evaluation of tropane-like 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909) analogues.
Journal of medicinal chemistry 2001;44(23):3937-45.
2001: Thomas Ullrich; Christina M Dersch; Richard B Rothman; Arthur E Jacobson; Kenner C Rice
Derivatives of 17-(2-methylallyl)-substituted noroxymorphone: variation of the delta address and its effects on affinity and selectivity for the delta opioid receptor.
Bioorganic & medicinal chemistry letters 2001;11(21):2883-5.
2001: James B Thomas; Robert N Atkinson; Richard B Rothman; Scott E Fix; Wayne Mascarella; N Ariane Vinson; Heng Xu; Christina M Dersch; Y Lu; Buddy E Cantrell; Dennis M Zimmerman; Frank carroll
Identification of the first trans-(3R,4R)- dimethyl-4-(3-hydroxyphenyl)piperidine derivative to possess highly potent and selective opioid kappa receptor antagonist activity.
Journal of medicinal chemistry 2001;44(17):2687-90.
2001: Heng Xu; Yi-Feng Lu; Kenner C Rice; Subramaniam Ananthan; Richard B Rothman
SoRI 9409, a non-peptide opioid mu receptor agonist/delta receptor antagonist, fails to stimulate [35S]-GTP-gamma-S binding at cloned opioid receptors.
Brain research bulletin 2001;55(4):507-11.
2001: Heng Xu; Yi-Feng Lu; J B Thomas; Frank carroll; Kenner C Rice; Richard B Rothman
Opioid peptide receptor studies. 15. Relative efficacy of 4-[(N-allyl-3-methyl-4-piperidinyl)phenylamino]-N,N-diethylbenzamide and related compounds at the cloned human delta-opioid receptor.
Synapse (New York, N.Y.) 2001;40(4):269-74.
2001: Michael H Baumann; Richard B Rothman; John Pablo; Deborah C Mash
In vivo neurobiological effects of ibogaine and its O-desmethyl metabolite, 12-hydroxyibogamine (noribogaine), in rats.
The Journal of pharmacology and experimental therapeutics 2001;297(2):531-9.
2001: Michael H Baumann; Mario A Ayestas; Christina M Dersch; Richard B Rothman
1-(m-chlorophenyl)piperazine (mCPP) dissociates in vivo serotonin release from long-term serotonin depletion in rat brain.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2001;24(5):492-501.
2001: S McLamore; Thomas Ullrich; Richard B Rothman; HAN XU; Christina M Dersch; Andrew Coop; P Davis; F Porreca; Arthur E Jacobson; Kenner C Rice
Effect of N-alkyl and N-alkenyl substituents in noroxymorphindole, 17-substituted-6,7-dehydro-4,5alpha-epoxy-3,14-dihydroxy-6,7:2',3'-indolomorphinans, on opioid receptor affinity, selectivity, and efficacy.
Journal of medicinal chemistry 2001;44(9):1471-4.
2001: James B Thomas; XM Herault; Richard B Rothman; Robert N Atkinson; Jason P Burgess; Wayne Mascarella; Christina M Dersch; Heng Xu; Judith L Flippen-Anderson; CF George; Frank carroll
Factors influencing agonist potency and selectivity for the opioid delta receptor are revealed in structure-activity relationship studies of the 4-[(N-substituted-4-piperidinyl)arylamino]-N,N-diethylbenzamides.
Journal of medicinal chemistry 2001;44(6):972-87.
2001: J P Pepper; Michael H Baumann; Mario A Ayestas; Richard B Rothman
Inhibition of MAO-A fails to alter cocaine-induced increases in extracellular dopamine and norepinephrine in rat nucleus accumbens.
Brain research. Molecular brain research 2001;87(2):184-9.
2001: Michael H Baumann; John Pablo; Syed F Ali; Richard B Rothman; Deborah C Mash
Comparative neuropharmacology of ibogaine and its O-desmethyl metabolite, noribogaine.
The Alkaloids. Chemistry and biology 2001;56():79-113.
2001: Heng Xu; A Hashimoto; Kenner C Rice; Arthur E Jacobson; J B Thomas; Frank carroll; J Lai; Richard B Rothman
Opioid peptide receptor studies. 14. Stereochemistry determines agonist efficacy and intrinsic efficacy in the [(35)S]GTP-gamma-S functional binding assay.
Synapse (New York, N.Y.) 2001;39(1):64-9.
2001: Richard B Rothman; Michael H Baumann; Christina M Dersch; D V Romero; Kenner C Rice; Frank carroll; John S Partilla
Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin.
Synapse (New York, N.Y.) 2001;39(1):32-41.
2000: Xiao-Hui Gu; Han Yu; Arthur E Jacobson; Richard B Rothman; Christina M Dersch; C George; Judith L Flippen-Anderson; Kenner C Rice
Design, synthesis, and monoamine transporter binding site affinities of methoxy derivatives of indatraline.
Journal of medicinal chemistry 2000;43(25):4868-76.
2000: Ying Zhang; Richard B Rothman; Christina M Dersch; B R de Costa; Arthur E Jacobson; Kenner C Rice
Synthesis and transporter binding properties of bridged piperazine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909).
Journal of medicinal chemistry 2000;43(25):4840-9.
2000: Richard B Rothman; Michael H Baumann; Jason E Savage; Laura Rauser; A McBride; Sandra J Hufeisen; Bryan L Roth
Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications.
Circulation 2000;102(23):2836-41.
2000: John S Partilla; Christina M Dersch; H Yu; Kenner C Rice; Richard B Rothman
Neurochemical neutralization of amphetamine-type stimulants in rat brain by the indatraline analog (-)-HY038.
Brain research bulletin 2000;53(6):821-6.
2000: Han Yu; Richard B Rothman; Christina M Dersch; John S Partilla; Kenner C Rice
Uptake and release effects of diethylpropion and its metabolites with biogenic amine transporters.
Bioorganic & medicinal chemistry 2000;8(12):2689-92.
2000: Michael H Baumann; John Pablo; Syed F Ali; Richard B Rothman; Deborah C Mash
Noribogaine (12-hydroxyibogamine): a biologically active metabolite of the antiaddictive drug ibogaine.
Annals of the New York Academy of Sciences 2000;914():354-68.
2000: Michael H Baumann; Mario A Ayestas; Christina M Dersch; John S Partilla; Richard B Rothman
Serotonin transporters, serotonin release, and the mechanism of fenfluramine neurotoxicity.
Annals of the New York Academy of Sciences 2000;914():172-86.
2000: Richard B Rothman; John S Partilla; Christina M Dersch; Frank carroll; Kenner C Rice; Michael H Baumann
Methamphetamine dependence: medication development efforts based on the dual deficit model of stimulant addiction.
Annals of the New York Academy of Sciences 2000;914():71-81.
2000: M Scott Furness; Xiaoyan Zhang; Andrew Coop; Arthur E Jacobson; Richard B Rothman; Christina M Dersch; HAN XU; F Porreca; Kenner C Rice
Probes for narcotic receptor-mediated phenomena. 27. Synthesis and pharmacological evaluation of selective delta-opioid receptor agonists from 4-[(alphaR)-alpha-(2S,5R)-4-substituted-2, 5-dimethyl-1-piperazinyl-3-methoxybenzyl]-N,N-diethylbenzamides and their enantiomers.
Journal of medicinal chemistry 2000;43(16):3193-6.
2000: James B Thomas; Robert N Atkinson; Richard B Rothman; Jason P Burgess; Wayne Mascarella; Christina M Dersch; Heng Xu; Frank carroll
4-[(8-Alkyl-8-azabicyclo[3.2.1]octyl-3-yl)-3-arylanilino]-N,N-diethylbenzamides: high affinity, selective ligands for the delta opioid receptor illustrate factors important to antagonist activity.
Bioorganic & medicinal chemistry letters 2000;10(11):1281-4.
2000: Michael H Baumann; Richard B Rothman; Syed F Ali
Comparative neurobiological effects of ibogaine and MK-801 in rats.
Drug and alcohol dependence 2000;59(2):143-51.
2000: Michael H Baumann; Mario A Ayestas; Christina M Dersch; A Brockington; Kenner C Rice; Richard B Rothman
Effects of phentermine and fenfluramine on extracellular dopamine and serotonin in rat nucleus accumbens: therapeutic implications.
Synapse (New York, N.Y.) 2000;36(2):102-13.
2000: Richard B Rothman; David A Gorelick; STEPHEN HEISHMAN; P R Eichmiller; B H Hill; J Norbeck; Joseph G Liberto
An open-label study of a functional opioid kappa antagonist in the treatment of opioid dependence.
Journal of substance abuse treatment 2000;18(3):277-81.
2000: SO Heyliger; Q Ni; Richard B Rothman
Resolution of two [(35)S]GTP-gamma-S binding sites and their response to chronic morphine treatment: a binding surface analysis.
Brain research bulletin 2000;51(4):357-62.
2000: Richard B Rothman; John S Partilla; Michael H Baumann; Christina M Dersch; Frank carroll; Kenner C Rice
Neurochemical neutralization of methamphetamine with high-affinity nonselective inhibitors of biogenic amine transporters: a pharmacological strategy for treating stimulant abuse.
Synapse (New York, N.Y.) 2000;35(3):222-7.
1999: Xiaoyan Zhang; Kenner C Rice; SN Calderon; H Kayakiri; L Smith; Andrew Coop; Arthur E Jacobson; Richard B Rothman; P Davis; Christina M Dersch; F Porreca
Probes for narcotic receptor mediated phenomena. 26. Synthesis and biological evaluation of diarylmethylpiperazines and diarylmethylpiperidines as novel, nonpeptidic delta opioid receptor ligands.
Journal of medicinal chemistry 1999;42(26):5455-63.
1999: Andrew Coop; J Pinto; L Wang; K McCullough; Richard B Rothman; Christina M Dersch; Arthur E Jacobson; Kenner C Rice
Delta opioid binding selectivity of 3-ether analogs of naltrindole.
Bioorganic & medicinal chemistry letters 1999;9(24):3435-8.
1999: SO Heyliger; C Jackson; Kenner C Rice; Richard B Rothman
Opioid peptide receptor studies. 10. Nor-BNI differentially inhibits kappa receptor agonist-induced G-protein activation in the guinea pig caudate: further evidence of kappa receptor heterogeneity.
Synapse (New York, N.Y.) 1999;34(4):256-65.
1999: James B Thomas; Robert N Atkinson; XM Herault; Richard B Rothman; Wayne Mascarella; Christina M Dersch; Heng Xu; Robert Horel; Frank carroll
Optically pure (-)-4-[(N-allyl-3-methyl-4-piperidinyl)phenyl-amino]-N,N-diethylbenzami de displays selective binding and full agonist activity for the delta opioid receptor.
Bioorganic & medicinal chemistry letters 1999;9(23):3347-50.
1999: D B Lewis; Dorota Matecka; Ying Zhang; Ling-Wei Hsin; Christina M Dersch; David Stafford; John R Glowa; Richard B Rothman; Kenner C Rice
Oxygenated analogues of 1-[2-(Diphenylmethoxy)ethyl]- and 1-[2-[Bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as potential extended-action cocaine-abuse therapeutic agents.
Journal of medicinal chemistry 1999;42(24):5029-42.
1999: Carl B Goodman; SO Heyliger; B Emilien; J S Partilla; H Y Yang; C H Lee; J L Cadet; Richard B Rothman
Chronic exposure to antibodies directed against anti-opiate peptides alter delta-opioid receptor levels.
Peptides 1999;20(12):1419-24.
1999: David M Donovan; LL Miner; M P Perry; RS Revay; Lawrence G Sharpe; Serge Przedborski; V Kostic; Rex Philpot; Cheryl L Kirstein; Richard B Rothman; Charles W Schindler; George R. Uhl
Cocaine reward and MPTP toxicity: alteration by regional variant dopamine transporter overexpression.
Brain research. Molecular brain research 1999;73(1-2):37-49.
1999: D V Romero; John S Partilla; Q X Zheng; SO Heyliger; Q Ni; Kenner C Rice; J Lai; Richard B Rothman
Opioid peptide receptor studies. 12. Buprenorphine is a potent and selective mu/kappa antagonist in the [35S]-GTP-gamma-S functional binding assay.
Synapse (New York, N.Y.) 1999;34(2):83-94.
1999: James B Thomas; XM Herault; Richard B Rothman; Jason P Burgess; Wayne Mascarella; Heng Xu; Robert Horel; Christina M Dersch; Frank carroll
(+/-)-4-[(N-allyl-cis-3-methyl-4-piperidinyl)phenylamino]-N,N-diethylbenzamide displays selective binding for the delta opioid receptor.
Bioorganic & medicinal chemistry letters 1999;9(20):3053-6.
1999: Subramaniam Ananthan; Hollis S Kezar; R L Carter; Surendra K Saini; Kenner C Rice; J L Wells; Peg Davis; Heng Xu; Christina M Dersch; Edward J Bilsky; Frank Porreca; Richard B Rothman
Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans.
Journal of medicinal chemistry 1999;42(18):3527-38.
1999: Richard B Rothman; Michael H Baumann; Christina M Dersch; J Appel; R A Houghten
Discovery of novel peptidic dopamine transporter ligands by screening a positional scanning combinatorial hexapeptide library.
Synapse (New York, N.Y.) 1999;33(3):239-46.
1999: Richard B Rothman; Mario A Ayestas; Christina M Dersch; Michael H Baumann
Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates. Implications for primary pulmonary hypertension.
Circulation 1999;100(8):869-75.
1999: Andrew Coop; Richard B Rothman; Christina M Dersch; John S Partilla; F Porreca; P Davis; Arthur E Jacobson; Kenner C Rice
delta Opioid affinity and selectivity of 4-hydroxy-3-methoxyindolomorphinan analogues related to naltrindole.
Journal of medicinal chemistry 1999;42(9):1673-9.
1999: Heng Xu; Yi-Feng Lu; John S Partilla; Q X Zheng; Jia Bei Wang; G A Brine; Frank carroll; Kenner C Rice; Kai-Xian Chen; Zhi-Qiang Chi; Richard B Rothman
Opioid peptide receptor studies, 11: involvement of Tyr148, Trp318 and His319 of the rat mu-opioid receptor in binding of mu-selective ligands.
Synapse (New York, N.Y.) 1999;32(1):23-8.
1999: F H Wojnicki; Richard B Rothman; Kenner C Rice; John R Glowa
Effects of phentermine on responding maintained under multiple fixed-ratio schedules of food and cocaine presentation in the rhesus monkey.
The Journal of pharmacology and experimental therapeutics 1999;288(2):550-60.
1998: James B Thomas; M J Fall; J B Cooper; Richard B Rothman; Wayne Mascarella; Heng Xu; John S Partilla; Christina M Dersch; KB McCullough; Buddy E Cantrell; Dennis M Zimmerman; Frank carroll
Identification of an opioid kappa receptor subtype-selective N-substituent for (+)-(3R,4R)-dimethyl-4-(3-hydroxyphenyl)piperidine.
Journal of medicinal chemistry 1998;41(26):5188-97.
1998: James B Thomas; Wayne Mascarella; Jason P Burgess; Heng Xu; KB McCullough; Richard B Rothman; Judith L Flippen-Anderson; CF George; Buddy E Cantrell; Dennis M Zimmerman; Frank carroll
N-substituted octahydro-4a-(3-hydroxyphenyl)-10a-methyl-benzo[g]isoquinolines are opioid receptor pure antagonists.
Bioorganic & medicinal chemistry letters 1998;8(22):3149-52.
1998: Michael H Baumann; Mario A Ayestas; Richard B Rothman
Functional consequences of central serotonin depletion produced by repeated fenfluramine administration in rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(21):9069-77.
1998: James B Thomas; X Zheng; Wayne Mascarella; Richard B Rothman; Christina M Dersch; John S Partilla; Judith L Flippen-Anderson; CF George; Buddy E Cantrell; Dennis M Zimmerman; Frank carroll
N-Substituted 9beta-methyl-5-(3-hydroxyphenyl)morphans are opioid receptor pure antagonists.
Journal of medicinal chemistry 1998;41(21):4143-9.
1998: Michael H Baumann; Richard B Rothman
Alterations in serotonergic responsiveness during cocaine withdrawal in rats: similarities to major depression in humans.
Biological psychiatry 1998;44(7):578-91.
1998: William Rea; Richard B Rothman; Toni S Shippenberg
Evaluation of the conditioned reinforcing effects of phentermine and fenfluramine in the rat: concordance with clinical studies.
Synapse (New York, N.Y.) 1998;30(1):107-11.
1998: Subramaniam Ananthan; Cheryl A Johnson; R L Carter; S D Clayton; Kenner C Rice; Heng Xu; Peg Davis; Frank Porreca; Richard B Rothman
Synthesis, opioid receptor binding, and bioassay of naltrindole analogues substituted in the indolic benzene moiety.
Journal of medicinal chemistry 1998;41(15):2872-81.
1998: Michael H Baumann; Richard B Rothman; Syed F Ali
Neurochemical and neuroendocrine effects of ibogaine in rats: comparison to MK-801.
Annals of the New York Academy of Sciences 1998;844():252-64.
1998: Michael H Baumann; Mario A Ayestas; Richard B Rothman
In vivo correlates of central serotonin function after high-dose fenfluramine administration.
Annals of the New York Academy of Sciences 1998;844():138-52.
1998: Richard B Rothman; Gregory I Elmer; Toni S Shippenberg; William Rea; Michael H Baumann
Phentermine and fenfluramine. Preclinical studies in animal models of cocaine addiction.
Annals of the New York Academy of Sciences 1998;844():59-74.
1998: James B Thomas; Wayne Mascarella; Richard B Rothman; John S Partilla; Heng Xu; KB McCullough; Christina M Dersch; Buddy E Cantrell; Dennis M Zimmerman; Frank carroll
Investigation of the N-substituent conformation governing potency and mu receptor subtype-selectivity in (+)-(3R, 4R)-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonists.
Journal of medicinal chemistry 1998;41(11):1980-90.
1998: H Kubota; Richard B Rothman; Christina M Dersch; K McCullough; J Pinto; Kenner C Rice
Synthesis and biological activity of 3-substituted 3-desoxynaltrindole derivatives.
Bioorganic & medicinal chemistry letters 1998;8(7):799-804.
1998: Richard B Rothman; M L Silverthorn; John R Glowa; Dorota Matecka; Kenner C Rice; Frank carroll; John S Partilla; George R. Uhl; David J Vandenbergh; Christina M Dersch
Studies of the biogenic amine transporters. VII. Characterization of a novel cocaine binding site identified with [125I]RTI-55 in membranes prepared from human, monkey and guinea pig caudate.
Synapse (New York, N.Y.) 1998;28(4):322-38.
1998: Yi-Feng Lu; Heng Xu; L Y Liu-Chen; C Chen; John S Partilla; G A Brine; Frank carroll; Kenner C Rice; J Lai; Frank Porreca; W Sadee; Richard B Rothman
Opioid peptide receptor studies. 7. The methylfentanyl congener RTI-4614-4 and its four enantiomers bind to different domains of the rat mu opioid receptor.
Synapse (New York, N.Y.) 1998;28(2):117-24.
1998: Carl B Goodman; SO Heyliger; B Emilien; J S Partilla; H Y Yang; C H Lee; J L Cadet; Richard B Rothman
Regulation of mu binding sites after chronic administration of antibodies directed against specific anti-opiate peptides.
Peptides 1998;19(10):1703-9.
1998: D C Ohuoha; Charles W Schindler; Richard B Rothman
Serotonin-4 receptor antagonists reverse cocaine-induced cardiac arrhythmia.
Life sciences 1998;63(19):1673-8.
1998: Q Ni; Heng Xu; John S Partilla; Kenner C Rice; Dorota Matecka; S N Calderon; Frank Porreca; J Lai; Helmut Schmidhammer; Roland Krassnig; Richard B Rothman
Opioid peptide receptor studies. 9. Identification of a novel non-mu- non-delta-like opioid peptide binding site in rat brain.
Peptides 1998;19(6):1079-90.
1998: SO Heyliger; K Payza; Richard B Rothman
The effect of FMRFamide analogs on [35S]GTP-gamma-S stimulation in squid optic lobes.
Peptides 1998;19(4):739-47.
1998: Heng Xu; Yi-Feng Lu; John S Partilla; J Pinto; S N Calderon; Dorota Matecka; Kenner C Rice; J Lai; Frank Porreca; Subramaniam Ananthan; Richard B Rothman
Opioid peptide receptor studies. 8. One of the mouse brain deltaNCX binding sites is similar to the cloned mouse opioid delta receptor: further evidence for heterogeneity of delta opioid receptors.
Peptides 1998;19(2):343-50.
1997: Y Katsura; Xiaoyan Zhang; K Homma; Kenner C Rice; SN Calderon; Richard B Rothman; Henry I Yamamura; P Davis; Judith L Flippen-Anderson; HAN XU; K Becketts; E J Foltz; F Porreca
Probes for narcotic receptor-mediated phenomena. 25. Synthesis and evaluation of N-alkyl-substituted (alpha-piperazinylbenzyl)benzamides as novel, highly selective delta opioid receptor agonists.
Journal of medicinal chemistry 1997;40(18):2936-47.
1997: M Shoaib; Michael H Baumann; Richard B Rothman; Steven R Goldberg; Charles W Schindler
Behavioural and neurochemical characteristics of phentermine and fenfluramine administered separately and as a mixture in rats.
Psychopharmacology 1997;131(3):296-306.
1997: D C Ohuoha; J A Maxwell; L E Thomson; J L Cadet; Richard B Rothman
Effect of dopamine receptor antagonists on cocaine subjective effects: a naturalistic case study.
Journal of substance abuse treatment 1997;14(3):249-58.
1997: John R Glowa; Kenner C Rice; Dorota Matecka; Richard B Rothman
Phentermine/fenfluramine decreases cocaine self-administration in rhesus monkeys.
Neuroreport 1997;8(6):1347-51.
1997: Dorota Matecka; David Lewis; Richard B Rothman; Christina M Dersch; F H Wojnicki; John R Glowa; AC DeVries; A Pert; Kenner C Rice
Heteroaromatic analogs of 1-[2-(diphenylmethoxy)ethyl]- and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as high-affinity dopamine reuptake inhibitors.
Journal of medicinal chemistry 1997;40(5):705-16.
1997: SN Calderon; Kenner C Rice; Richard B Rothman; F Porreca; Judith L Flippen-Anderson; H Kayakiri; HAN XU; K Becketts; L E Smith; E J Bilsky; P Davis; R Horvath
Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective delta agonist (+)-4-[(alpha R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- N,N-diethylbenzamide (SNC 80) and related novel nonpeptide delta opioid receptor ligands.
Journal of medicinal chemistry 1997;40(5):695-704.
1996: Richard B Rothman; Mario A Ayestas; Michael H Baumann
Phentermine pretreatment antagonizes the cocaine-induced rise in mesolimbic dopamine.
Neuroreport 1996;8(1):7-9.
1996: Dorota Matecka; Richard B Rothman; L Radesca; B R de Costa; Christina M Dersch; John S Partilla; A Pert; John R Glowa; F H Wojnicki; Kenner C Rice
Development of novel, potent, and selective dopamine reuptake inhibitors through alteration of the piperazine ring of 1-[2-(diphenylmethoxy)ethyl]-and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909).
Journal of medicinal chemistry 1996;39(24):4704-16.
1996: John R Glowa; W E Fantegrossi; D B Lewis; Dorota Matecka; Kenner C Rice; Richard B Rothman
Sustained decrease in cocaine-maintained responding in rhesus monkeys with 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-hydroxy-3-phenylpropyl) piperazinyl decanoate, a long-acting ester derivative of GBR 12909.
Journal of medicinal chemistry 1996;39(24):4689-91.
1996: Wallace B Pickworth; Michael H Baumann; Reginald V Fant; Richard B Rothman; Jack E Henningfield
Endocrine responses during acute nicotine withdrawal.
Pharmacology, biochemistry, and behavior 1996;55(3):433-7.
1996: Richard J Knapp; G Santoro; I A De Leon; K B Lee; S A Edsall; Sue Waite; Ewa Malatynska; E Varga; SN Calderon; Kenner C Rice; Richard B Rothman; F Porreca; William R Roeske; Henry I Yamamura
Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors.
The Journal of pharmacology and experimental therapeutics 1996;277(3):1284-91.
1996: C M Bertha; M Ellis; Judith L Flippen-Anderson; F Porreca; Richard B Rothman; P Davis; HAN XU; K Becketts; Kenner C Rice
Probes for narcotic receptor-mediated phenomena. 21. Novel derivatives of 3-(1,2,3,4,5,11-hexahydro-3-methyl-2,6-methano-6H-azocino[4,5-b]indol- 6-yl)-phenols with improved delta opioid receptor selectivity.
Journal of medicinal chemistry 1996;39(10):2081-6.
1996: Michael H Baumann; Charles R Schuster; Richard B Rothman
Effects of phentermine and cocaine on fenfluramine-induced depletion of serotonin in mouse brain.
Drug and alcohol dependence 1996;41(1):71-4.
1996: Gregory I Elmer; A Brockington; David A Gorelick; F I Carrol; Kenner C Rice; Dorota Matecka; Steven R Goldberg; Richard B Rothman
Cocaine cross-sensitization to dopamine uptake inhibitors: unique effects of GBR12909.
Pharmacology, biochemistry, and behavior 1996;53(4):911-8.
1996: E J Bilsky; R N Bernstein; Victor J Hruby; Richard B Rothman; Josephine Lai; F Porreca
Characterization of antinociception to opioid receptor selective agonists after antisense oligodeoxynucleotide-mediated "knock-down" of opioid receptor in vivo.
The Journal of pharmacology and experimental therapeutics 1996;277(1):491-501.
1996: Gregory I Elmer; David A Gorelick; Steven R Goldberg; Richard B Rothman
Acute sensitivity vs. context-specific sensitization to cocaine as a function of genotype.
Pharmacology, biochemistry, and behavior 1996;53(3):623-8.
1996: Michael H Baumann; Richard B Rothman
Chronic cocaine exposure potentiates prolactin and head shake responses to 5-HT2 receptor stimulation in rats.
Neuropharmacology 1996;35(3):295-301.
1996: Carl B Goodman; B Emilien; K Becketts; Jean Lud Cadet; Richard B Rothman
Downregulation of mu-opioid binding sites following chronic administration of neuropeptide FF (NPFF) and morphine.
Peptides 1996;17(3):389-97.
1995: Michael H Baumann; T M Gendron; K M Becketts; Jack E Henningfield; David A Gorelick; Richard B Rothman
Effects of intravenous cocaine on plasma cortisol and prolactin in human cocaine abusers.
Biological psychiatry 1995;38(11):751-5.
1995: C M Bertha; BJ Vilner; M V Mattson; Wayne D Bowen; K Becketts; HAN XU; Richard B Rothman; Judith L Flippen-Anderson; Kenner C Rice
(E)-8-benzylidene derivatives of 2-methyl-5-(3-hydroxyphenyl)morphans: highly selective ligands for the sigma 2 receptor subtype.
Journal of medicinal chemistry 1995;38(24):4776-85.
1995: X Y Cha; Heng Xu; Q Ni; John S Partilla; Kenner C Rice; Dorota Matecka; S N Calderon; F Porreca; J Lai; Richard B Rothman
Opioid peptide receptor studies. 4. Antisense oligodeoxynucleotide to the delta opioid receptor delineates opioid receptor subtypes.
Regulatory peptides 1995;59(2):247-53.
1995: Jean Lud Cadet; Bruce Ladenheim; H Hirata; Richard B Rothman; S Ali; E Carlson; C Epstein; Timothy H Moran
Superoxide radicals mediate the biochemical effects of methylenedioxymethamphetamine (MDMA): evidence from using CuZn-superoxide dismutase transgenic mice.
Synapse (New York, N.Y.) 1995;21(2):169-76.
1995: Richard B Rothman; Heng Xu; Jia Bei Wang; John S Partilla; H Kayakiri; Kenner C Rice; George R. Uhl
Ligand selectivity of cloned human and rat opioid mu receptors.
Synapse (New York, N.Y.) 1995;21(1):60-4.
1995: Michael H Baumann; K M Becketts; Richard B Rothman
Evidence for alterations in presynaptic serotonergic function during withdrawal from chronic cocaine in rats.
European journal of pharmacology 1995;282(1-3):87-93.
1995: Jean Lud Cadet; S F Ali; Richard B Rothman; C J Epstein
Neurotoxicity, drugs and abuse, and the CuZn-superoxide dismutase transgenic mice.
Molecular neurobiology 1995;11(1-3):155-63.
1995: Richard B Rothman; John R Glowa
A review of the effects of dopaminergic agents on humans, animals, and drug-seeking behavior, and its implications for medication development. Focus on GBR 12909.
Molecular neurobiology 1995;11(1-3):1-19.
1995: Richard B Rothman; M L Silverthorn; Michael H Baumann; Carl B Goodman; Jean Lud Cadet; Dorota Matecka; Kenner C Rice; Frank carroll; Jia Bei Wang; George R. Uhl
Studies of the biogenic amine transporters. VI. Characterization of a novel cocaine binding site, identified with [125I]RTI-55, in membranes prepared from whole rat brain minus caudate.
The Journal of pharmacology and experimental therapeutics 1995;274(1):385-95.
1995: Michael H Baumann; Richard B Rothman
Repeated cocaine administration reduces 5-HT1A-mediated prolactin secretion in rats.
Neuroscience letters 1995;193(1):9-12.
1995: John S Partilla; J You; Richard B Rothman
High-performance liquid chromatographic resolution of synthetic opiate and "anti-opiate" peptides from human plasma.
Journal of chromatography. B, Biomedical applications 1995;667(1):49-56.
1995: G A Brine; P A Stark; Y Liu; Frank carroll; P Singh; H Xu; Richard B Rothman
Enantiomers of diastereomeric cis-N-[1-(2-hydroxy-2-phenylethyl)- 3-methyl-4-piperidyl]-N-phenylpropanamides: synthesis, X-ray analysis, and biological activities.
Journal of medicinal chemistry 1995;38(9):1547-57.
1995: C M Bertha; Judith L Flippen-Anderson; Richard B Rothman; F Porreca; P Davis; HAN XU; K Becketts; X Y Cha; Kenner C Rice
Probes for narcotic receptor-mediated phenomena. 20. Alteration of opioid receptor subtype selectivity of the 5-(3-hydroxyphenyl)morphans by application of the message-address concept: preparation of delta-opioid receptor ligands.
Journal of medicinal chemistry 1995;38(9):1523-37.
1995: H Hirata; Bruce Ladenheim; Richard B Rothman; C Epstein; Jean Lud Cadet
Methamphetamine-induced serotonin neurotoxicity is mediated by superoxide radicals.
Brain research 1995;677(2):345-7.
1995: E J Bilsky; SN Calderon; T Wang; R N Bernstein; P Davis; Victor J Hruby; R W McNutt; Richard B Rothman; Kenner C Rice; F Porreca
SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist.
The Journal of pharmacology and experimental therapeutics 1995;273(1):359-66.
1995: M L Silverthorn; Christina M Dersch; Michael H Baumann; Jean Lud Cadet; John S Partilla; Kenner C Rice; Frank carroll; K M Becketts; A Brockington; Richard B Rothman
Studies of the biogenic amine transporters. V. Demonstration of two binding sites for the cocaine analog [125I]RTI-55 associated with the 5-HT transporter in rat brain membranes.
The Journal of pharmacology and experimental therapeutics 1995;273(1):213-22.
1995: Heng Xu; Carl B Goodman; John S Partilla; Q Ni; H Kayakiri; Kenner C Rice; Richard B Rothman
6 beta-[125iodo]-3, 14-dihydroxy-17-methyl-4, 5 alpha-epoxymorphinan ([125I]IOXY-AGO): a potent and selective radioligand for opioid mu receptors.
Synapse (New York, N.Y.) 1995;19(2):105-11.
1995: Q Ni; Heng Xu; John S Partilla; B R de Costa; Kenner C Rice; H Kayakiri; Richard B Rothman
Opioid peptide receptor studies. 3. Interaction of opioid peptides and other drugs with four subtypes of the kappa 2 receptor in guinea pig brain.
Peptides 1995;16(6):1083-95.
1995: X Y Cha; Heng Xu; Kenner C Rice; F Porreca; J Lai; S Ananthan; Richard B Rothman
Opioid peptide receptor studies. 1. Identification of a novel delta-opioid receptor binding site in rat brain membranes.
Peptides 1995;16(2):191-8.
1994: Michael H Baumann; G U Char; B R De Costa; Kenner C Rice; Richard B Rothman
GBR12909 attenuates cocaine-induced activation of mesolimbic dopamine neurons in the rat.
The Journal of pharmacology and experimental therapeutics 1994;271(3):1216-22.
1994: Richard B Rothman; David A Gorelick; Michael H Baumann; X Y Guo; Ronald I Herning; Wallace B Pickworth; T M Gendron; B Koeppl; L E Thomson; Jack E Henningfield
Lack of evidence for context-dependent cocaine-induced sensitization in humans: preliminary studies.
Pharmacology, biochemistry, and behavior 1994;49(3):583-8.
1994: Josephine Lai; S W Ma; R H Zhu; Richard B Rothman; K U Lentes; F Porreca
Pharmacological characterization of the cloned kappa opioid receptor as a kappa 1b subtype.
Neuroreport 1994;5(16):2161-4.
1994: Richard B Rothman; A Pert
Effects of electroconvulsive shock on the retention of cocaine-induced conditioning.
Pharmacology, biochemistry, and behavior 1994;49(2):399-404.
1994: C M Bertha; M V Mattson; Judith L Flippen-Anderson; Richard B Rothman; HAN XU; X Y Cha; K Becketts; Kenner C Rice
A marked change of receptor affinity of the 2-methyl-5-(3-hydroxyphenyl)morphans upon attachment of an (E)-8-benzylidene moiety: synthesis and evaluation of a new class of sigma receptor ligands.
Journal of medicinal chemistry 1994;37(19):3163-70.
1994: Q Ni; Heng Xu; John S Partilla; B R de Costa; Kenner C Rice; Anna Borsodi; S Hosztafi; Richard B Rothman
Dihydrocodeinone-hydrazone, dihydrocodeinone-oxime, naloxone-3-OMe-oxime, and clocinnamox fail to irreversibly inhibit opioid kappa receptor binding.
Neurochemical research 1994;19(9):1159-63.
1994: SN Calderon; Richard B Rothman; F Porreca; Judith L Flippen-Anderson; R W McNutt; HAN XU; L E Smith; E J Bilsky; P Davis; Kenner C Rice
Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): a highly selective, nonpeptide delta opioid receptor agonist.
Journal of medicinal chemistry 1994;37(14):2125-8.
1994: Richard B Rothman; Jean Lud Cadet; H C Akunne; M L Silverthorn; Michael H Baumann; Frank carroll; Kenner C Rice; B R de Costa; John S Partilla; Jia Bei Wang
Studies of the biogenic amine transporters. IV. Demonstration of a multiplicity of binding sites in rat caudate membranes for the cocaine analog [125I]RTI-55.
The Journal of pharmacology and experimental therapeutics 1994;270(1):296-309.
1994: Richard B Rothman
PCP site 2: a high affinity MK-801-insensitive phencyclidine binding site.
Neurotoxicology and teratology 1994;16(4):343-53.
1994: Josephine Lai; E J Bilsky; Richard B Rothman; F Porreca
Treatment with antisense oligodeoxynucleotide to the opioid delta receptor selectively inhibits delta 2-agonist antinociception.
Neuroreport 1994;5(9):1049-52.
1994: H C Akunne; J A Monn; A Thurkauf; Arthur E Jacobson; Kenner C Rice; J T Linders; Q Jiang; F Porreca; Richard B Rothman
An electrophilic affinity ligand based on (+)-MK801 distinguishes PCP site 1 from PCP site 2.
Neurochemical research 1994;19(4):385-9.
1994: H C Akunne; Christina M Dersch; Jean Lud Cadet; Michael H Baumann; G U Char; John S Partilla; B R de Costa; Kenner C Rice; Frank carroll; Richard B Rothman
Studies of the biogenic amine transporters. III. Demonstration of two binding sites for [3H]GBR12935 and [3H]BTCP in rat caudate membranes.
The Journal of pharmacology and experimental therapeutics 1994;268(3):1462-75.
1994: Christina M Dersch; H C Akunne; John S Partilla; G U Char; B R de Costa; Kenner C Rice; Frank carroll; Richard B Rothman
Studies of the biogenic amine transporters. 1. Dopamine reuptake blockers inhibit [3H]mazindol binding to the dopamine transporter by a competitive mechanism: preliminary evidence for different binding domains.
Neurochemical research 1994;19(2):201-8.
1994: Richard B Rothman
A review of the effects of dopaminergic agents in humans: implications for medication development.
NIDA research monograph 1994;145():67-87.
1993: Q Ni; Heng Xu; John S Partilla; P A Stark; Frank carroll; G A Brine; Richard B Rothman
Stereochemical requirements for pseudoirreversible inhibition of opioid mu receptor binding by the 3-methylfentanyl congeners, RTI-46144 and its enantiomers: evidence for different binding domains.
Synapse (New York, N.Y.) 1993;15(4):296-306.
1993: Q Ni; Heng Xu; John S Partilla; B R de Costa; Kenner C Rice; Richard B Rothman
Selective labeling of kappa 2 opioid receptors in rat brain by [125I]IOXY: interaction of opioid peptides and other drugs with multiple kappa 2a binding sites.
Peptides 1993;14(6):1279-93.
1993: Richard B Rothman; L S Brady; Heng Xu; J B Long
Chronic intracerebroventricular infusion of the antiopioid peptide, Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2 (NPFF), downregulates mu opioid binding sites in rat brain.
Peptides 1993;14(6):1271-7.
1993: Michael H Baumann; A M Brockington; Richard B Rothman
Withdrawal from chronic cocaine enhances behavioral sensitivity to the 5-HT2/1C agonist DOI.
Biological psychiatry 1993;34(8):576-7.
1993: Heng Xu; John S Partilla; B R de Costa; Kenner C Rice; Richard B Rothman
Differential binding of opioid peptides and other drugs to two subtypes of opioid delta ncx binding sites in mouse brain: further evidence for delta receptor heterogeneity.
Peptides 1993;14(5):893-907.
1993: Michael H Baumann; T J Raley; John S Partilla; Richard B Rothman
Biosynthesis of dopamine and serotonin in the rat brain after repeated cocaine injections: a microdissection mapping study.
Synapse (New York, N.Y.) 1993;14(1):40-50.
1993: Richard B Rothman; B Lewis; Christina M Dersch; Heng Xu; L Radesca; B R de Costa; Kenner C Rice; R B Kilburn; H C Akunne; A Pert
Identification of a GBR12935 homolog, LR1111, which is over 4,000-fold selective for the dopamine transporter, relative to serotonin and norepinephrine transporters.
Synapse (New York, N.Y.) 1993;14(1):34-9.
1993: Michael H Baumann; Richard B Rothman
Effects of acute and chronic cocaine on the activity of tuberoinfundibular dopamine neurons in the rat.
Brain research 1993;608(1):175-9.
1993: Richard B Rothman; K M Becketts; L R Radesca; B R de Costa; Kenner C Rice; Frank carroll; Christina M Dersch
Studies of the biogenic amine transporters. II. A brief study on the use of [3H]DA-uptake-inhibition to transporter-binding-inhibition ratios for the in vitro evaluation of putative cocaine antagonists.
Life sciences 1993;53(17):PL267-72.
1993: Richard B Rothman; Heng Xu; G U Char; A Kim; B R De Costa; Kenner C Rice; D M Zimmerman
Phenylpiperidine opioid antagonists that promote weight loss in rats have high affinity for the kappa 2B (enkephalin-sensitive) binding site.
Peptides 1993;14(1):17-20.
1992: Richard B Rothman; N Grieg; A Kim; B R De Costa; Kenner C Rice; Frank carroll; A Pert
Cocaine and GBR12909 produce equivalent motoric responses at different occupancy of the dopamine transporter.
Pharmacology, biochemistry, and behavior 1992;43(4):1135-42.
1992: H C Akunne; B R de Costa; Arthur E Jacobson; Kenner C Rice; Richard B Rothman
[3H] cocaine labels a binding site associated with the serotonin transporter in guinea pig brain: allosteric modulation by paroxetine.
Neurochemical research 1992;17(12):1275-83.
1992: Heng Xu; John S Partilla; B R de Costa; Kenner C Rice; Richard B Rothman
Interaction of opioid peptides and other drugs with multiple delta ncx binding sites in rat brain: further evidence for heterogeneity.
Peptides 1992;13(6):1207-13.
1992: Richard B Rothman; A Mahboubi; V Bykov; C H Kim; B R de Costa; Arthur E Jacobson; Kenner C Rice
Probing the opioid receptor complex with (+)-trans-SUPERFIT. II. Evidence that mu ligands are noncompetitive inhibitors of the delta cx opioid peptide binding site.
Peptides 1992;13(6):1137-43.
1992: Richard B Rothman
A review of the role of anti-opioid peptides in morphine tolerance and dependence.
Synapse (New York, N.Y.) 1992;12(2):129-38.
1992: Richard B Rothman; V Bykov; B G Xue; Heng Xu; B R De Costa; Arthur E Jacobson; Kenner C Rice; J E Kleinman; L S Brady
Interaction of opioid peptides and other drugs with multiple kappa receptors in rat and human brain. Evidence for species differences.
Peptides 1992;13(5):977-87.
1992: Mark G Swain; Richard B Rothman; HAN XU; John Vergalla; Nora V Bergasa; E Anthony Jones
Endogenous opioids accumulate in plasma in a rat model of acute cholestasis.
Gastroenterology 1992;103(2):630-5.
1992: B R de Costa; Michael Iadarola; Richard B Rothman; K F Berman; C George; Amy Hauck Newman; A Mahboubi; Arthur E Jacobson; Kenner C Rice
Probes for narcotic receptor mediated phenomena. 18. Epimeric 6 alpha- and 6 beta-iodo-3,14-dihydroxy-17-(cyclopropylmethyl)-4,5 alpha-epoxymorphinans as potential ligands for opioid receptor single photon emission computed tomography: synthesis, evaluation, and radiochemistry of [125I]-6 beta-iodo-3,14-dihydroxy-17-(cyclopropylmethyl)-4,5 alpha-epoxymorphinan.
Journal of medicinal chemistry 1992;35(15):2826-35.
1992: Richard B Rothman; V Bykov; Arthur E Jacobson; Kenner C Rice; J E Long; W D Bowen
A study of the effect of the irreversible delta receptor antagonist [D-Ala2,Leu5,Cys6]-enkephalin on delta cx and delta ncx opioid binding sites in vitro and in vivo.
Peptides 1992;13(4):691-4.
1992: Nora V Bergasa; Richard B Rothman; John Vergalla; HAN XU; Mark G Swain; E Anthony Jones
Central mu-opioid receptors are down-regulated in a rat model of cholestasis.
Journal of hepatology 1992;15(1-2):220-4.
1992: H C Akunne; J N Johannessen; B R de Costa; Kenner C Rice; Richard B Rothman
MPTP lesions of the nigrostriatal dopaminergic projection decrease [3H]1-[1-(2-thienyl)cyclohexyl]piperidine binding to PCP site 2: further evidence that PCP site 2 is associated with the biogenic amine reuptake complex.
Neurochemical research 1992;17(3):261-4.
1992: B de Costa; Richard B Rothman; Wayne D Bowen; L Radesca; L Band; A Reid; L D Paolo; J M Walker; Arthur E Jacobson; Kenner C Rice
Novel kappa opioid receptor and sigma ligands.
NIDA research monograph 1992;119():76-80.
1991: Richard B Rothman; A Mele; A A Reid; H C Akunne; N Greig; A Thurkauf; B R de Costa; Kenner C Rice; A Pert
GBR12909 antagonizes the ability of cocaine to elevate extracellular levels of dopamine.
Pharmacology, biochemistry, and behavior 1991;40(2):387-97.
1991: H C Akunne; A A Reid; A Thurkauf; Arthur E Jacobson; B R de Costa; Kenner C Rice; M P Heyes; Richard B Rothman
[3H]1-[2-(2-thienyl)cyclohexyl]piperidine labels two high-affinity binding sites in human cortex: further evidence for phencyclidine binding sites associated with the biogenic amine reuptake complex.
Synapse (New York, N.Y.) 1991;8(4):289-300.
1991: Richard B Rothman; V Bykov; A Mahboubi; J B Long; Q Jiang; F Porreca; B R de Costa; Arthur E Jacobson; Kenner C Rice; John Holaday
Interaction of beta-funaltrexamine with [3H]cycloFOXY binding in rat brain: further evidence that beta-FNA alkylates the opioid receptor complex.
Synapse (New York, N.Y.) 1991;8(2):86-99.
1991: HAN XU; C H Kim; Y C Zhu; Richard J. Weber; Arthur E Jacobson; Kenner C Rice; Richard B Rothman
(+)-cis-3-methylfentanyl and its analogs bind pseudoirreversibly to the mu opioid binding site: evidence for pseudoallosteric modulation.
Neuropharmacology 1991;30(5):455-62.
1991: Richard B Rothman; A Mahboubi; V Bykov; C H Kim; Arthur E Jacobson; Kenner C Rice
Probing the opioid receptor complex with (+)-trans-superfit. I. Evidence that [D-Pen2,D-Pen5]enkephalin interacts with high affinity at the delta cx binding site.
Peptides 1991;12(2):359-64.
1991: Richard B Rothman; A Reid; A Mahboubi; C H Kim; B R De Costa; Arthur E Jacobson; Kenner C Rice
Labeling by [3H]1,3-di(2-tolyl)guanidine of two high affinity binding sites in guinea pig brain: evidence for allosteric regulation by calcium channel antagonists and pseudoallosteric modulation by sigma ligands.
Molecular pharmacology 1991;39(2):222-32.
1991: HAN XU; Q Ni; Arthur E Jacobson; Kenner C Rice; Richard B Rothman
Preliminary ligand binding data for subtypes of the delta opioid receptor in rat brain membranes.
Life sciences 1991;49(18):PL141-6.
1991: Richard B Rothman; J B Long; V Bykov; H Xu; Arthur E Jacobson; Kenner C Rice; John Holaday
Upregulation of the opioid receptor complex by the chronic administration of morphine: a biochemical marker related to the development of tolerance and dependence.
Peptides 1991;12(1):151-60.
1991: Richard B Rothman; HAN XU; M Seggel; Arthur E Jacobson; Kenner C Rice; G A Brine; F I Carroll
RTI-4614-4: an analog of (+)-cis-3-methylfentanyl with a 27,000-fold binding selectivity for mu versus delta opioid binding sites.
Life sciences 1991;48(23):PL111-6.
1990: J A Qi; W D Bowen; Henry I Mosberg; Richard B Rothman; F Porreca
Opioid agonist and antagonist antinociceptive properties of [D-Ala2,Leu5,Cys6]enkephalin: selective actions at the deltanoncomplexed site.
The Journal of pharmacology and experimental therapeutics 1990;255(2):636-41.
1990: B R de Costa; Kenner C Rice; Wayne D Bowen; A Thurkauf; Richard B Rothman; L Band; Arthur E Jacobson; L Radesca; P C Contreras; N M Gray
Synthesis and evaluation of N-substituted cis-N-methyl-2-(1-pyrrolidinyl)cyclohexylamines as high affinity sigma receptor ligands. Identification of a new class of highly potent and selective sigma receptor probes.
Journal of medicinal chemistry 1990;33(11):3100-10.
1990: A A Reid; C H Kim; A Thurkauf; J A Monn; B de Costa; Arthur E Jacobson; Kenner C Rice; Wayne D Bowen; Richard B Rothman
Wash-resistant inhibition of phencyclidine- and haloperidol-sensitive sigma receptor sites in guinea pig brain by putative affinity ligands: determination of selectivity.
Neuropharmacology 1990;29(11):1047-53.
1990: A A Reid; M V Mattson; B R de Costa; A Thurkauf; Arthur E Jacobson; J A Monn; Kenner C Rice; Richard B Rothman
Specificity of phencyclidine-like drugs and benzomorphan opiates for two high affinity phencyclidine binding sites in guinea pig brain.
Neuropharmacology 1990;29(9):811-7.
1990: Richard B Rothman; J B Long; V Bykov; Arthur E Jacobson; Kenner C Rice; John Holaday
Pretreatment of rats with the irreversible mu-receptor antagonist, beta-FNA, fails to prevent naltrexone-induced upregulation of mu-opioid receptors.
Neuropharmacology 1990;29(9):805-10.
1990: B R de Costa; Richard B Rothman; V Bykov; L Band; A Pert; Arthur E Jacobson; Kenner C Rice
Probes for narcotic receptor mediated phenomena. 17. Synthesis and evaluation of a series of trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacet amide (U50,488) related isothiocyanate derivatives as opioid receptor affinity ligands.
Journal of medicinal chemistry 1990;33(4):1171-6.
1990: Richard B Rothman; V Bykov; B R de Costa; Arthur E Jacobson; Kenner C Rice; L S Brady
Interaction of endogenous opioid peptides and other drugs with four kappa opioid binding sites in guinea pig brain.
Peptides 1990;11(2):311-31.
1990: L Band; HAN XU; V Bykov; N Greig; C H Kim; A Newman; Arthur E Jacobson; Kenner C Rice; Richard B Rothman
The potent opioid agonist, (+)-cis-3-methylfentanyl binds pseudoirreversibly to the opioid receptor complex in vitro and in vivo: evidence for a novel mechanism of action.
Life sciences 1990;47(24):2231-40.
1990: A A Reid; J A Monn; Arthur E Jacobson; Kenner C Rice; Richard B Rothman
Pseudoallosteric modulation by (+)-MK801 of NMDA-coupled phencyclidine binding sites.
Life sciences 1990;47(16):PL77-82.
1990: Richard B Rothman; V Bykov; B R de Costa; Arthur E Jacobson; Kenner C Rice; L S Brady
Evidence for four opioid kappa binding sites in guinea pig brain.
Progress in clinical and biological research 1990;328():9-12.
1990: L Band; B R de Costa; V Bykov; A Pert; Kenner C Rice; Richard B Rothman
The affinity ligand "UPHIT" acylates kappa opioid binding sites in vivo.
Progress in clinical and biological research 1990;328():77-80.
1990: Richard B Rothman
High affinity dopamine reuptake inhibitors as potential cocaine antagonists: a strategy for drug development.
Life sciences 1990;46(20):PL17-21.
1990: H Akunne; B R deCosta; Kenner C Rice; Arthur E Jacobson; Richard B Rothman
Evidence for high and low affinity [3H]cocaine binding sites associated with the serotonin reuptake complex in guinea pig brain: allosteric modulation by paroxetine.
NIDA research monograph 1990;105():547-8.
1990: Richard B Rothman; A Mele; A A Reid; H Akunne; N Grieg; A Thurkauf; B R deCosta; Kenner C Rice; A Pert
Preliminary evidence that the high affinity dopamine reuptake inhibitor, GBR12909, antagonizes the ability of cocaine to elevate extracellular levels of dopamine.
NIDA research monograph 1990;105():359-60.
1990: A A Reid; Wayne D Bowen; C Setterlund; Richard B Rothman
The competitive NMDA receptor antagonist, CPP, allosterically modulates NMDA receptor associated PCP binding sites in the absence of steric hinderance.
NIDA research monograph 1990;105():339-40.
1990: HAN XU; C H Kim; Y C Zhu; Richard J. Weber; Kenner C Rice; Richard B Rothman
Pseudoirreversible binding of opiates to opioid receptor subtypes in rat brain: a quantitative study.
NIDA research monograph 1990;105():410-1.
1990: N A Grayson; Richard B Rothman; HAN XU; Kenner C Rice
Pharmacological properties of (+)-buprenorphine and (+)-diprenorphine.
NIDA research monograph 1990;105():380-1.
1990: Richard B Rothman; A Mahboubi; A A Reid; C H Kim; B R deCosta; Arthur E Jacobson; Kenner C Rice
[3H]1,3-Di(2-tolyl)guanidine labels two high affinity binding sites in guinea pig brain: evidence for allosteric regulation by calcium channel blockers and sigma ligands.
NIDA research monograph 1990;105():335-6.
1990: Richard B Rothman; H Y Yang; J B Long
Upregulation of rat brain opioid receptors by the chronic administration of morphine: possible evidence for an anti-opiate model of tolerance and dependence.
NIDA research monograph 1990;105():264-70.
1989: C Benkelfat; C S Aulakh; V Bykov; Kenner C Rice; B R De Costa; Richard B Rothman
Apparent down-regulation of rat brain mu- and kappa-opioid binding sites labelled with [3H]cycloFOXY following chronic administration of the potent 5-hydroxytryptamine reuptake blocker, clomipramine.
The Journal of pharmacy and pharmacology 1989;41(12):865-7.
1989: Richard B Rothman; J B Long; John Holaday; V Bykov; B R de Costa; C H Kim; Arthur E Jacobson; Kenner C Rice
A study of the interaction of the alkylating agent, NIH10236, with opioid receptors in vitro and in vivo.
Neuropharmacology 1989;28(12):1349-56.
1989: Richard B Rothman; A A Reid; J A Monn; Arthur E Jacobson; Kenner C Rice
The psychotomimetic drug phencyclidine labels two high affinity binding sites in guinea pig brain: evidence for N-methyl-D-aspartate-coupled and dopamine reuptake carrier-associated phencyclidine binding sites.
Molecular pharmacology 1989;36(6):887-96.
1989: Richard B Rothman; A Mele; A A Reid; H Akunne; N Greig; A Thurkauf; Kenner C Rice; A Pert
Tight binding dopamine reuptake inhibitors as cocaine antagonists. A strategy for drug development.
FEBS letters 1989;257(2):341-4.
1989: J S Heyman; Q Jiang; Richard B Rothman; Henry I Mosberg; F Porreca
Modulation of mu-mediated antinociception by delta agonists: characterization with antagonists.
European journal of pharmacology 1989;169(1):43-52.
1989: Richard B Rothman; Charles France; V Bykov; B R De Costa; Arthur E Jacobson; James H Woods; Kenner C Rice
Pharmacological activities of optically pure enantiomers of the kappa opioid agonist, U50,488, and its cis diastereomer: evidence for three kappa receptor subtypes.
European journal of pharmacology 1989;167(3):345-53.
1989: B R de Costa; Wayne D Bowen; S B Hellewell; C George; Richard B Rothman; A A Reid; J Michael Walker; Arthur E Jacobson; Kenner C Rice
Alterations in the stereochemistry of the kappa-selective opioid agonist U50,488 result in high-affinity sigma ligands.
Journal of medicinal chemistry 1989;32(8):1996-2002.
1989: B R de Costa; L Band; Richard B Rothman; Arthur E Jacobson; V Bykov; A Pert; Kenner C Rice
Synthesis of an affinity ligand ('UPHIT') for in vivo acylation of the kappa-opioid receptor.
FEBS letters 1989;249(2):178-82.
1989: C H Kim; Richard B Rothman; Arthur E Jacobson; M V Mattson; V Bykov; R A Streaty; W A Klee; C George; J B Long; Kenner C Rice
Probes for narcotic receptor mediated phenomena. 15. (3S,4S)-(+)-trans-3-methylfentanyl isothiocyanate, a potent site-directed acylating agent for the delta opioid receptors in vitro.
Journal of medicinal chemistry 1989;32(6):1392-8.
1989: Richard B Rothman; V Bykov; J B Long; L S Brady; Arthur E Jacobson; Kenner C Rice; John Holaday
Chronic administration of morphine and naltrexone up-regulate mu-opioid binding sites labeled by [3H][D-Ala2,MePhe4,Gly-ol5]enkephalin: further evidence for two mu-binding sites.
European journal of pharmacology 1989;160(1):71-82.
1989: L Band; V Bykov; N Greig; C H Kim; A Hauck-Newman; Arthur E Jacobson; Kenner C Rice; Richard B Rothman
In vivo binding of (+)-cis methylfentanyl at the opiate receptor complex and behavioral correlates: evidence for a novel mechanism of action.
NIDA research monograph 1989;95():554-5.
1989: A A Reid; J A Monn; Arthur E Jacobson; Kenner C Rice; Richard B Rothman
Characterization of NMDA-coupled and dopamine reuptake carrier coupled [3H]-TCP binding sites in guinea pig brain.
NIDA research monograph 1989;95():530-1.
1988: Richard B Rothman; V Bykov; A Reid; B R De Costa; A H Newman; Arthur E Jacobson; Kenner C Rice
A brief study of the selectivity of norbinaltorphimine, (-)-cyclofoxy, and (+)-cyclofoxy among opioid receptor subtypes in vitro.
Neuropeptides 1988;12(3):181-7.
1988: Richard B Rothman; V Bykov; A H Newman; Arthur E Jacobson; Kenner C Rice
Interaction of enantiomeric pairs of opiates with phencyclidine binding sites in rat brain: identification of (+) pentazocine as a ligand potentially suitable for imaging sigma binding sites using positron emission tomography.
Neuropeptides 1988;12(1):1-5.
1988: Richard B Rothman; S McLean
An examination of the opiate receptor subtypes labeled by [3H]cycloFOXY: an opiate antagonist suitable for positron emission tomography.
Biological psychiatry 1988;23(5):435-58.
1988: Richard B Rothman; V Bykov; D Ofri; Kenner C Rice
LY164929: a highly selective ligand for the lower affinity [3H]D-Ala2-D-Leu-5-enkephalin binding site.
Neuropeptides 1988;11(1):13-6.
1988: Richard B Rothman; V Bykov; Kenner C Rice; Arthur E Jacobson; G N Kooper; W D Bowen
Tritiated-6-beta-fluoro-6-desoxy-oxymorphone ([3H]FOXY): a new ligand and photoaffinity probe for the mu opioid receptors.
Neuropeptides 1988;11(1):1-6.
1987: Richard B Rothman; V Bykov; J L Cadet; J E Kleinman
A postmortem study of the effect of chronic opiate abuse on psychotomimetic binding sites of human frontal cortex.
Neuropeptides 1987;10(3):261-4.