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Nancy Rothwell

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
28
Luheshi, Giamal
21
Pinteaux, Emmanuel
20
Allan, Stuart
18
Hopkins, Stephen
13
Little, Roderick
12
Loddick, Sarah
12
Brough, David
11
Horan, Michael
11
Kimber, Ian
9
Gibson, Rosemary
8
Dascombe, Michael
8
Tyrrell, Pippa
7
Boutin, Herve
7
Le Feuvre, Rosalind
6
Lawrence, Catherine

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Publications

TOP 3
Chapman Katie Z; Dale Verity Q; Dénes Adám; Bennett Gavin; Rothwell Nancy J; Allan Stuart M; McColl Barry W
A rapid and transient peripheral inflammatory response precedes brain inflammation after experimental stroke.
Luheshi N M; Rothwell N J; Brough D
Dual functionality of interleukin-1 family cytokines: implications for anti-interleukin-1 therapy.
Skinner R A; Gibson R M; Rothwell N J; Pinteaux E; Penny J I
Transport of interleukin-1 across cerebromicrovascular endothelial cells.

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All Publications

2009: Chapman Katie Z; Dale Verity Q; Dénes Adám; Bennett Gavin; Rothwell Nancy J; Allan Stuart M; McColl Barry W
A rapid and transient peripheral inflammatory response precedes brain inflammation after experimental stroke.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2009;29(11):1764-8.
2009: Luheshi N M; Rothwell N J; Brough D
Dual functionality of interleukin-1 family cytokines: implications for anti-interleukin-1 therapy.
British journal of pharmacology 2009;157(8):1318-29.
2009: Skinner R A; Gibson R M; Rothwell N J; Pinteaux E; Penny J I
Transport of interleukin-1 across cerebromicrovascular endothelial cells.
British journal of pharmacology 2009;156(7):1115-23.
2009: Brough David; Pelegrin Pablo; Rothwell Nancy J
Pannexin-1-dependent caspase-1 activation and secretion of IL-1beta is regulated by zinc.
European journal of immunology 2009;39(2):352-8.
2009: McColl B W; Allan S M; Rothwell N J
Systemic infection, inflammation and acute ischemic stroke.
Neuroscience 2009;158(3):1049-61.
2009: Luheshi Nadia M; Rothwell Nancy J; Brough David
The dynamics and mechanisms of interleukin-1alpha and beta nuclear import.
Traffic (Copenhagen, Denmark) 2009;10(1):16-25.
2008: Wang Penglian; Rothwell Nancy J; Pinteaux Emmanuel; Brough David
Neuronal injury induces the release of pro-interleukin-1beta from activated microglia in vitro.
Brain research 2008;1236():1-7.
2008: McColl Barry W; Rothwell Nancy J; Allan Stuart M
Systemic inflammation alters the kinetics of cerebrovascular tight junction disruption after experimental stroke in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(38):9451-62.
2008: Tsakiri Niki; Kimber Ian; Rothwell Nancy J; Pinteaux Emmanuel
Differential effects of interleukin-1 alpha and beta on interleukin-6 and chemokine synthesis in neurones.
Molecular and cellular neurosciences 2008;38(2):259-65.
2008: Parry-Jones Adrian R; Liimatainen Timo; Kauppinen Risto A; Gröhn Olli H J; Rothwell Nancy J
Interleukin-1 exacerbates focal cerebral ischemia and reduces ischemic brain temperature in the rat.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2008;59(6):1239-49.
2008: Gueorguieva Ivelina; Clark Simon R; McMahon Catherine J; Scarth Sylvia; Rothwell Nancy J; Tyrrell Pippa J; Hopkins Stephen J; Rowland Malcolm
Pharmacokinetic modelling of interleukin-1 receptor antagonist in plasma and cerebrospinal fluid of patients following subarachnoid haemorrhage.
British journal of clinical pharmacology 2008;65(3):317-25.
2008: Tsakiri N; Kimber I; Rothwell N J; Pinteaux E
Interleukin-1-induced interleukin-6 synthesis is mediated by the neutral sphingomyelinase/Src kinase pathway in neurones.
British journal of pharmacology 2008;153(4):775-83.
2008: Clark Simon R; McMahon Catherine J; Gueorguieva Iva; Rowland Malcolm; Scarth Sylvia; Georgiou Rachel; Tyrrell Pippa J; Hopkins Stephen J; Rothwell Nancy J
Interleukin-1 receptor antagonist penetrates human brain at experimentally therapeutic concentrations.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(2):387-94.
2008: Thornton Peter; Pinteaux Emmanuel; Allan Stuart M; Rothwell Nancy J
Matrix metalloproteinase-9 and urokinase plasminogen activator mediate interleukin-1-induced neurotoxicity.
Molecular and cellular neurosciences 2008;37(1):135-42.
2008: Tsakiri Niki; Kimber Ian; Rothwell Nancy J; Pinteaux Emmanuel
Mechanisms of interleukin-6 synthesis and release induced by interleukin-1 and cell depolarisation in neurones.
Molecular and cellular neurosciences 2008;37(1):110-8.
2007: McColl B W; Allan S M; Rothwell N J
Systemic inflammation and stroke: aetiology, pathology and targets for therapy.
Biochemical Society transactions 2007;35(Pt 5):1163-5.
2007: Ross Jerard; Brough David; Gibson Rosemary M; Loddick Sarah A; Rothwell Nancy J
A selective, non-peptide caspase-1 inhibitor, VRT-018858, markedly reduces brain damage induced by transient ischemia in the rat.
Neuropharmacology 2007;53(5):638-42.
2007: Pinteaux Emmanuel; Inoue Wataru; Schmidt Lorraine; Molina-Holgado Francisco; Rothwell Nancy J; Luheshi Giamal N
Leptin induces interleukin-1beta release from rat microglial cells through a caspase 1 independent mechanism.
Journal of neurochemistry 2007;102(3):826-33.
2007: McColl Barry W; Rothwell Nancy J; Allan Stuart M
Systemic inflammatory stimulus potentiates the acute phase and CXC chemokine responses to experimental stroke and exacerbates brain damage via interleukin-1- and neutrophil-dependent mechanisms.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(16):4403-12.
2007: Brough David; Rothwell Nancy J
Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death.
Journal of cell science 2007;120(Pt 5):772-81.
2007: Miggin Sinead M; Pålsson-McDermott Eva; Dunne Aisling; Jefferies Caroline; Pinteaux Emmanuel; Banahan Kathy; Murphy Caroline; Moynagh Paul; Yamamoto Masahiro; Akira Shizuo; Rothwell Nancy; Golenbock Douglas; Fitzgerald Katherine A; O'Neill Luke A J
NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3372-7.
2007: Watson P Marc D; Humphries Martin J; Relton Jane; Rothwell Nancy J; Verkhratsky Alex; Gibson Rosemary M
Integrin-binding RGD peptides induce rapid intracellular calcium increases and MAPK signaling in cortical neurons.
Molecular and cellular neurosciences 2007;34(2):147-54.
2007: Emsley Hedley C A; Smith Craig J; Gavin Carole M; Georgiou Rachel F; Vail Andy; Barberan Elisa M; Illingworth Karen; Scarth Sylvia; Wickramasinghe Vijitha; Hoadley Margaret E; Rothwell Nancy J; Tyrrell Pippa J; Hopkins Stephen J
Clinical outcome following acute ischaemic stroke relates to both activation and autoregulatory inhibition of cytokine production.
BMC neurology 2007;7():5.
2006: Smith Craig J; Emsley Hedley C A; Vail Andy; Georgiou Rachel F; Rothwell Nancy J; Tyrrell Pippa J; Hopkins Stephen J
Variability of the systemic acute phase response after ischemic stroke.
Journal of the neurological sciences 2006;251(1-2):77-81.
2006: Skinner Robert; Georgiou Rachel; Thornton Peter; Rothwell Nancy
Psychoneuroimmunology of stroke.
Neurologic clinics 2006;24(3):561-83.
2006: Thornton Peter; Pinteaux Emmanuel; Gibson Rosemary M; Allan Stuart M; Rothwell Nancy J
Interleukin-1-induced neurotoxicity is mediated by glia and requires caspase activation and free radical release.
Journal of neurochemistry 2006;98(1):258-66.
2006: Pinteaux Emmanuel; Rothwell Nancy J; Boutin Herve
Neuroprotective actions of endogenous interleukin-1 receptor antagonist (IL-1ra) are mediated by glia.
Glia 2006;53(5):551-6.
2006: Andre Ralph; Moggs Jonathan G; Kimber Ian; Rothwell Nancy J; Pinteaux Emmanuel
Gene regulation by IL-1beta independent of IL-1R1 in the mouse brain.
Glia 2006;53(5):477-83.
2006: Patel H C; Ross F M; Heenan L E; Davies R E; Rothwell N J; Allan S M
Neurodegenerative actions of interleukin-1 in the rat brain are mediated through increases in seizure activity.
Journal of neuroscience research 2006;83(3):385-91.
2006: Lucas Sian-Marie; Rothwell Nancy J; Gibson Rosemary M
The role of inflammation in CNS injury and disease.
British journal of pharmacology 2006;147 Suppl 1():S232-40.
2005: Emsley H C A; Smith C J; Georgiou R F; Vail A; Hopkins S J; Rothwell N J; Tyrrell P J;
A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients.
Journal of neurology, neurosurgery, and psychiatry 2005;76(10):1366-72.
2005: Andre Ralph; Lerouet Dominique; Kimber Ian; Pinteaux Emmanuel; Rothwell Nancy J
Regulation of expression of the novel IL-1 receptor family members in the mouse brain.
Journal of neurochemistry 2005;95(2):324-30.
2005: Allan Stuart M; Tyrrell Pippa J; Rothwell Nancy J
Interleukin-1 and neuronal injury.
Nature reviews. Immunology 2005;5(8):629-40.
2005: Wang Penglian; Meinhardt Brenda; Andre Ralph; Renshaw Blair R; Kimber Ian; Rothwell Nancy J; Pinteaux Emmanuel
The interleukin-1-related cytokine IL-1F8 is expressed in glial cells, but fails to induce IL-1beta signalling responses.
Cytokine 2005;29(6):245-50.
2005: Andre Ralph; Pinteaux Emmanuel; Kimber Ian; Rothwell Nancy J
Differential actions of IL-1 alpha and IL-1 beta in glial cells share common IL-1 signalling pathways.
Neuroreport 2005;16(2):153-7.
2005: Emsley Hedley C A; Smith Craig J; Georgiou Rachel F; Vail Andy; Tyrrell Pippa J; Barberan Elisa M; Rothwell Nancy J; Hopkins Stephen J
Correlation of systemic inflammatory response with infarct volume in acute ischemic stroke patients.
Stroke; a journal of cerebral circulation 2005;36(2):228-9; author reply 228-9.
2005: Molina-Holgado Francisco; Pinteaux Emmanuel; Heenan Laura; Moore Jonathan D; Rothwell Nancy J; Gibson Rosemary M
Neuroprotective effects of the synthetic cannabinoid HU-210 in primary cortical neurons are mediated by phosphatidylinositol 3-kinase/AKT signaling.
Molecular and cellular neurosciences 2005;28(1):189-94.
2004: Gibson Rosemary M; Rothwell Nancy J; Le Feuvre Ros A
CNS injury: the role of the cytokine IL-1.
Veterinary journal (London, England : 1997) 2004;168(3):230-7.
2004: Rothwell Nancy
One more thing...
Nature 2004;427(6976):683.
2004: Smith Craig J; Emsley Hedley C A; Gavin Carole M; Georgiou Rachel F; Vail Andy; Barberan Elisa M; del Zoppo Gregory J; Hallenbeck John M; Rothwell Nancy J; Hopkins Stephen J; Tyrrell Pippa J
Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome.
BMC neurology 2004;4():2.
2003: Andre Ralph; Wheeler Rachel D; Collins Peter D; Luheshi Giamal N; Pickering-Brown Stuart; Kimber Ian; Rothwell Nancy J; Pinteaux Emmanuel
Identification of a truncated IL-18R beta mRNA: a putative regulator of IL-18 expressed in rat brain.
Journal of neuroimmunology 2003;145(1-2):40-5.
2003: Ross Fiona M; Allan Stuart M; Rothwell Nancy J; Verkhratsky Alexej
A dual role for interleukin-1 in LTP in mouse hippocampal slices.
Journal of neuroimmunology 2003;144(1-2):61-7.
2003: Allan Stuart M; Rothwell Nancy J
Inflammation in central nervous system injury.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2003;358(1438):1669-77.
2003: Mulcahy Nicholas J; Ross Jerard; Rothwell Nancy J; Loddick Sarah A
Delayed administration of interleukin-1 receptor antagonist protects against transient cerebral ischaemia in the rat.
British journal of pharmacology 2003;140(3):471-6.
2003: Molina-Holgado Francisco; Pinteaux Emmanuel; Moore Jonathan D; Molina-Holgado Eduardo; Guaza Carmen; Gibson Rosemary M; Rothwell Nancy J
Endogenous interleukin-1 receptor antagonist mediates anti-inflammatory and neuroprotective actions of cannabinoids in neurons and glia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(16):6470-4.
2003: Boutin Herve; Kimber Ian; Rothwell Nancy J; Pinteaux Emmanuel
The expanding interleukin-1 family and its receptors: do alternative IL-1 receptor/signaling pathways exist in the brain?
Molecular neurobiology 2003;27(3):239-48.
2003: Emsley Hedley C A; Smith Craig J; Gavin Carole M; Georgiou Rachel F; Vail Andy; Barberan Elisa M; Hallenbeck John M; del Zoppo Gregory J; Rothwell Nancy J; Tyrrell Pippa J; Hopkins Stephen J
An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosis.
Journal of neuroimmunology 2003;139(1-2):93-101.
2003: Berglöf Elisabet; Andre Ralph; Renshaw Blair R; Allan Stuart M; Lawrence Catherine B; Rothwell Nancy J; Pinteaux Emmanuel
IL-1Rrp2 expression and IL-1F9 (IL-1H1) actions in brain cells.
Journal of neuroimmunology 2003;139(1-2):36-43.
2003: Wheeler Rachel D; Brough David; Le Feuvre Rosalind A; Takeda Kiyoshi; Iwakura Yoichiro; Luheshi Giamal N; Rothwell Nancy J
Interleukin-18 induces expression and release of cytokines from murine glial cells: interactions with interleukin-1 beta.
Journal of neurochemistry 2003;85(6):1412-20.
2003: Rothwell Nancy
Interleukin-1 and neuronal injury: mechanisms, modification, and therapeutic potential.
Brain, behavior, and immunity 2003;17(3):152-7.
2003: Wheeler Rachel D; Boutin Herve; Touzani Omar; Luheshi Giamal N; Takeda Kiyoshi; Rothwell Nancy J
No role for interleukin-18 in acute murine stroke-induced brain injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2003;23(5):531-5.
2003: Brough David; Le Feuvre Rosalind A; Wheeler Rachel D; Solovyova Natasha; Hilfiker Sabine; Rothwell Nancy J; Verkhratsky Alex
Ca2+ stores and Ca2+ entry differentially contribute to the release of IL-1 beta and IL-1 alpha from murine macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(6):3029-36.
2003: Le Feuvre Rosalind A; Brough David; Touzani Omar; Rothwell Nancy J
Role of P2X7 receptors in ischemic and excitotoxic brain injury in vivo.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2003;23(3):381-4.
2003: Wheeler Rachel D; Young Elizabeth A; Rothwell Nancy J; Hall Matthew D; Luheshi Giamal N
Up-regulation of IL-18BP, but not IL-18 mRNA in rat liver by LPS.
Cytokine 2003;21(4):161-6.
2002: Pinteaux Emmanuel; Parker Lisa C; Rothwell Nancy J; Luheshi Giamal N
Expression of interleukin-1 receptors and their role in interleukin-1 actions in murine microglial cells.
Journal of neurochemistry 2002;83(4):754-63.
2002: Oakden Elizabeth; Chiswick Malcolm; Rothwell Nancy; Loddick Sarah
The influence of litter size on brain damage caused by hypoxic-ischemic injury in the neonatal rat.
Pediatric research 2002;52(5):692-6.
2002: Le Feuvre Rosalind; Brough David; Rothwell Nancy
Extracellular ATP and P2X7 receptors in neurodegeneration.
European journal of pharmacology 2002;447(2-3):261-9.
2002: Parker Lisa C; Luheshi Giamal N; Rothwell Nancy J; Pinteaux Emmanuel
IL-1 beta signalling in glial cells in wildtype and IL-1RI deficient mice.
British journal of pharmacology 2002;136(2):312-20.
2002: Molina-Holgado Francisco; Molina-Holgado Eduardo; Guaza Carmen; Rothwell Nancy J
Role of CB1 and CB2 receptors in the inhibitory effects of cannabinoids on lipopolysaccharide-induced nitric oxide release in astrocyte cultures.
Journal of neuroscience research 2002;67(6):829-36.
2002: Moore Jonathan D; Rothwell Nancy J; Gibson Rosemary M
Involvement of caspases and calpains in cerebrocortical neuronal cell death is stimulus-dependent.
British journal of pharmacology 2002;135(4):1069-77.
2002: Brough David; Le Feuvre Rosalind A; Iwakura Yoichiro; Rothwell Nancy J
Purinergic (P2X7) receptor activation of microglia induces cell death via an interleukin-1-independent mechanism.
Molecular and cellular neurosciences 2002;19(2):272-80.
2002: Grundy Robert I; Rothwell Nancy J; Allan Stuart M
Site-specific actions of interleukin-1 on excitotoxic cell death in the rat striatum.
Brain research 2002;926(1-2):142-8.
2002: Ellacott Kate L J; Lawrence Catherine B; Rothwell Nancy J; Luckman Simon M
PRL-releasing peptide interacts with leptin to reduce food intake and body weight.
Endocrinology 2002;143(2):368-74.
2002: Le Feuvre Rosalind A; Brough David; Iwakura Yoichiro; Takeda Kiyoshi; Rothwell Nancy J
Priming of macrophages with lipopolysaccharide potentiates P2X7-mediated cell death via a caspase-1-dependent mechanism, independently of cytokine production.
The Journal of biological chemistry 2002;277(5):3210-8.
2002: Touzani Omar; Boutin Herve; LeFeuvre Rosalind; Parker Lisa; Miller Andy; Luheshi Giamal; Rothwell Nancy
Interleukin-1 influences ischemic brain damage in the mouse independently of the interleukin-1 type I receptor.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(1):38-43.
2001: Allan S M; Rothwell N J
Cytokines and acute neurodegeneration.
Nature reviews. Neuroscience 2001;2(10):734-44.
2001: Allan S M; Harrison D C; Read S; Collins B; Parsons A A; Philpott K; Rothwell N J
Selective increases in cytokine expression in the rat brain in response to striatal injection of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate and interleukin-1.
Brain research. Molecular brain research 2001;93(2):180-9.
2001: Rothwell N
Thermogenesis: where are we and where are we going? Report of a workshop held in London 21st April 2001, convened by Professor Mike Stock.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2001;25(9):1272-4.
2001: Craighead M W; Middlehurst K M; LeFeuvre R; Kimber I; Rothwell N J
Oxidised adenosine 5'-triphosphate, a P2X(7) antagonist, is toxic to rat cerebellar granule neurones in vitro.
Neuroscience letters 2001;311(2):77-80.
2001: Boutin H; LeFeuvre R A; Horai R; Asano M; Iwakura Y; Rothwell N J
Role of IL-1alpha and IL-1beta in ischemic brain damage.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(15):5528-34.
2001: Lawrence C B; Rothwell N J
Anorexic but not pyrogenic actions of interleukin-1 are modulated by central melanocortin-3/4 receptors in the rat.
Journal of neuroendocrinology 2001;13(6):490-5.
2001: Molina-Holgado F; Grencis R; Rothwell N J
Actions of exogenous and endogenous IL-10 on glial responses to bacterial LPS/cytokines.
Glia 2001;33(2):97-106.
2001: Cartmell T; Luheshi G N; Hopkins S J; Rothwell N J; Poole S
Role of endogenous interleukin-1 receptor antagonist in regulating fever induced by localised inflammation in the rat.
The Journal of physiology 2001;531(Pt 1):171-80.
2000: Rothwell N J; Luheshi G N
Interleukin 1 in the brain: biology, pathology and therapeutic target.
Trends in neurosciences 2000;23(12):618-25.
2000: Zampronio A R; Hoadley M E; Luheshi G; Rothwell N J; de Souza G E; Hopkins S J
Interleukin (IL)-6 release and fever induced by a pre-formed pyrogenic factor (PFPF) derived from LPS-stimulated macrophages.
European cytokine network 2000;11(4):589-96.
2000: Molina-Holgado F; Toulmond S; Rothwell N J
Involvement of interleukin-1 in glial responses to lipopolysaccharide: endogenous versus exogenous interleukin-1 actions.
Journal of neuroimmunology 2000;111(1-2):1-9.
2000: Allan S M; Rothwell N J
Cortical death caused by striatal administration of AMPA and interleukin-1 is mediated by activation of cortical NMDA receptors.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2000;20(10):1409-13.
2000: Craighead M W; Boutin H; Middlehurst K M; Allan S M; Brooks N; Kimber I; Rothwell N J
Influence of corticotrophin releasing factor on neuronal cell death in vitro and in vivo.
Brain research 2000;881(2):139-43.
2000: Cartmell T; Poole S; Turnbull A V; Rothwell N J; Luheshi G N
Circulating interleukin-6 mediates the febrile response to localised inflammation in rats.
The Journal of physiology 2000;526 Pt 3():653-61.
2000: Parker L C; Rushforth D A; Rothwell N J; Luheshi G N
IL-1beta induced changes in hypothalamic IL-1R1 and IL-1R2 mRNA expression in the rat.
Brain research. Molecular brain research 2000;79(1-2):156-8.
2000: Rothwell N J
Show them how it's really done.
Nature 2000;405(6787):621.
2000: Wheeler R D; Culhane A C; Hall M D; Pickering-Brown S; Rothwell N J; Luheshi G N
Detection of the interleukin 18 family in rat brain by RT-PCR.
Brain research. Molecular brain research 2000;77(2):290-3.
2000: Allan S M; Parker L C; Collins B; Davies R; Luheshi G N; Rothwell N J
Cortical cell death induced by IL-1 is mediated via actions in the hypothalamus of the rat.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5580-5.
1999: Touzani O; Boutin H; Chuquet J; Rothwell N
Potential mechanisms of interleukin-1 involvement in cerebral ischaemia.
Journal of neuroimmunology 1999;100(1-2):203-15.
1999: Lawrence C B; Turnbull A V; Rothwell N J
Hypothalamic control of feeding.
Current opinion in neurobiology 1999;9(6):778-83.
1999: Artis D; Humphreys N E; Bancroft A J; Rothwell N J; Potten C S; Grencis R K
Tumor necrosis factor alpha is a critical component of interleukin 13-mediated protective T helper cell type 2 responses during helminth infection.
The Journal of experimental medicine 1999;190(7):953-62.
1999: Loddick S A; Rothwell N J
Mechanisms of tumor necrosis factor alpha action on neurodegeneration: interaction with insulin-like growth factor-1.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(17):9449-51.
1999: Cartmell T; Luheshi G N; Rothwell N J
Brain sites of action of endogenous interleukin-1 in the febrile response to localized inflammation in the rat.
The Journal of physiology 1999;518 ( Pt 2)():585-94.
1999: Luheshi G N; Gardner J D; Rushforth D A; Loudon A S; Rothwell N J
Leptin actions on food intake and body temperature are mediated by IL-1.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(12):7047-52.
1999: Grundy R I; Rothwell N J; Allan S M
Dissociation between the effects of interleukin-1 on excitotoxic brain damage and body temperature in the rat.
Brain research 1999;830(1):32-7.
1999: Pearson V L; Rothwell N J; Toulmond S
Excitotoxic brain damage in the rat induces interleukin-1beta protein in microglia and astrocytes: correlation with the progression of cell death.
Glia 1999;25(4):311-23.
1999: Davies C A; Loddick S A; Toulmond S; Stroemer R P; Hunt J; Rothwell N J
The progression and topographic distribution of interleukin-1beta expression after permanent middle cerebral artery occlusion in the rat.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1999;19(1):87-98.
1999: Rothwell N J
Annual review prize lecture cytokines - killers in the brain?
The Journal of physiology 1999;514 ( Pt 1)():3-17.
1998: Davies C A; Loddick S A; Stroemer R P; Hunt J; Rothwell N J
An integrated analysis of the progression of cell responses induced by permanent focal middle cerebral artery occlusion in the rat.
Experimental neurology 1998;154(1):199-212.
1998: Cartmell T; Poole S; Rothwell N J; Luheshi G N
Relationship between interleukin-1 and interleukin-1 receptor antagonist during the development of fever in the rat.
Annals of the New York Academy of Sciences 1998;856():252-5.
1998: Anforth H R; Bluthe R M; Bristow A; Hopkins S; Lenczowski M J; Luheshi G; Lundkvist J; Michaud B; Mistry Y; Van Dam A M; Zhen C; Dantzer R; Poole S; Rothwell N J; Tilders F J; Wollman E E
Biological activity and brain actions of recombinant rat interleukin-1alpha and interleukin-1beta.
European cytokine network 1998;9(3):279-88.
1998: Stroemer R P; Rothwell N J
Exacerbation of ischemic brain damage by localized striatal injection of interleukin-1beta in the rat.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1998;18(8):833-9.
1998: Culhane A C; Hall M D; Rothwell N J; Luheshi G N
Cloning of rat brain interleukin-18 cDNA.
Molecular psychiatry 1998;3(4):362-6.
1998: Ochu E E; Rothwell N J; Waters C M
Caspases mediate 6-hydroxydopamine-induced apoptosis but not necrosis in PC12 cells.
Journal of neurochemistry 1998;70(6):2637-40.
1998: Lawrence C B; Allan S M; Rothwell N J
Interleukin-1beta and the interleukin-1 receptor antagonist act in the striatum to modify excitotoxic brain damage in the rat.
The European journal of neuroscience 1998;10(3):1188-95.
1998: Allan S M; Lawrence C B; Rothwell N J
Interleukin-1 beta and interleukin-1 receptor antagonist do not affect glutamate release or calcium entry in rat striatal synaptosomes.
Molecular psychiatry 1998;3(2):178-82.
1998: Roe S Y; McGowan E M; Rothwell N J
Evidence for the involvement of corticotrophin-releasing hormone in the pathogenesis of traumatic brain injury.
The European journal of neuroscience 1998;10(2):553-9.
1998: Loddick S A; Turnbull A V; Rothwell N J
Cerebral interleukin-6 is neuroprotective during permanent focal cerebral ischemia in the rat.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1998;18(2):176-9.
1997: Rothwell N; Allan S; Toulmond S
The role of interleukin 1 in acute neurodegeneration and stroke: pathophysiological and therapeutic implications.
The Journal of clinical investigation 1997;100(11):2648-52.
1997: Rothwell N J
Sixteenth Gaddum Memorial Lecture December 1996. Neuroimmune interactions: the role of cytokines.
British journal of pharmacology 1997;121(5):841-7.
1997: Stroemer R P; Rothwell N J
Cortical protection by localized striatal injection of IL-1ra following cerebral ischemia in the rat.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1997;17(6):597-604.
1997: Roe S Y; Rothwell N J
Whole body metabolic responses to brain trauma in the rat.
Journal of neurotrauma 1997;14(6):399-408.
1997: Loddick S A; Wong M L; Bongiorno P B; Gold P W; Licinio J; Rothwell N J
Endogenous interleukin-1 receptor antagonist is neuroprotective.
Biochemical and biophysical research communications 1997;234(1):211-5.
1997: Roe S Y; Cooper A L; Morris I D; Rothwell N J
Involvement of prostaglandins in cachexia induced by T-cell leukemia in the rat.
Metabolism: clinical and experimental 1997;46(4):359-65.
1997: Roe S Y; Cooper A L; Morris I D; Hopkins S J; Rothwell N J
Involvement of cytokines in cachexia induced by T-cell leukaemia in the rat.
European cytokine network 1997;8(1):45-9.
1997: Rothwell N J
Cytokines and acute neurodegeneration.
Molecular psychiatry 1997;2(2):120-1.
1997: Rothwell N J; Loddick S A; Stroemer P
Interleukins and cerebral ischaemia.
International review of neurobiology 1997;40():281-98.
1996: Loddick S A; Rothwell N J
Neuroprotective effects of human recombinant interleukin-1 receptor antagonist in focal cerebral ischaemia in the rat.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1996;16(5):932-40.
1996: Stefferl A; Hopkins S J; Rothwell N J; Luheshi G N
The role of TNF-alpha in fever: opposing actions of human and murine TNF-alpha and interactions with IL-beta in the rat.
British journal of pharmacology 1996;118(8):1919-24.
1996: Loddick S A; MacKenzie A; Rothwell N J
An ICE inhibitor, z-VAD-DCB attenuates ischaemic brain damage in the rat.
Neuroreport 1996;7(9):1465-8.
1996: Roe S; Cooper A L; Morris I D; Rothwell N J
Mechanisms of cachexia induced by T-cell leukemia in the rat.
Metabolism: clinical and experimental 1996;45(5):645-51.
1996: Sudlow A W; Carey F; Forder R; Rothwell N J
The role of lipocortin-1 in dexamethasone-induced suppression of PGE2 and TNF alpha release from human peripheral blood mononuclear cells.
British journal of pharmacology 1996;117(7):1449-56.
1996: Luheshi G; Rothwell N
Cytokines and fever.
International archives of allergy and immunology 1996;109(4):301-7.
1996: Luheshi G; Miller A J; Brouwer S; Dascombe M J; Rothwell N J; Hopkins S J
Interleukin-1 receptor antagonist inhibits endotoxin fever and systemic interleukin-6 induction in the rat.
The American journal of physiology 1996;270(1 Pt 1):E91-5.
1996: Sudlow A W; Carey F; Forder R; Rothwell N J
Lipocortin-1 inhibits CRH stimulation of plasma ACTH and IL-1 beta-stimulated hypothalamic CRH release in rats.
The American journal of physiology 1996;270(1 Pt 2):R54-60.
1996: Rothwell N J; Luheshi G; Toulmond S
Cytokines and their receptors in the central nervous system: physiology, pharmacology, and pathology.
Pharmacology & therapeutics 1996;69(2):85-95.
1995: Wong M L; Loddick S A; Bongiorno P B; Gold P W; Rothwell N J; Licinio J
Focal cerebral ischemia induces CRH mRNA in rat cerebral cortex and amygdala.
Neuroreport 1995;6(13):1785-8.
1995: Coelho M M; Luheshi G; Hopkins S J; Pelá I R; Rothwell N J
Multiple mechanisms mediate antipyretic action of glucocorticoids.
The American journal of physiology 1995;269(3 Pt 2):R527-35.
1995: Rothwell N J; Strijbos P J
Cytokines in neurodegeneration and repair.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1995;13(3-4):179-85.
1995: Strijbos P J; Rothwell N J
Interleukin-1 beta attenuates excitatory amino acid-induced neurodegeneration in vitro: involvement of nerve growth factor.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(5 Pt 1):3468-74.
1995: Rothwell N J; Hopkins S J
Cytokines and the nervous system II: Actions and mechanisms of action.
Trends in neurosciences 1995;18(3):130-6.
1995: Toulmond S; Rothwell N J
Interleukin-1 receptor antagonist inhibits neuronal damage caused by fluid percussion injury in the rat.
Brain research 1995;671(2):261-6.
1995: Hopkins S J; Rothwell N J
Cytokines and the nervous system. I: Expression and recognition.
Trends in neurosciences 1995;18(2):83-8.
1994: Cooper A L; Brouwer S; Turnbull A V; Luheshi G N; Hopkins S J; Kunkel S L; Rothwell N J
Tumor necrosis factor-alpha and fever after peripheral inflammation in the rat.
The American journal of physiology 1994;267(6 Pt 2):R1431-6.
1994: Strijbos P J; Relton J K; Rothwell N J
Corticotrophin-releasing factor antagonist inhibits neuronal damage induced by focal cerebral ischaemia or activation of NMDA receptors in the rat brain.
Brain research 1994;656(2):405-8.
1994: Rothwell N J; Luheshi G
Pharmacology of interleukin-1 actions in the brain.
Advances in pharmacology (San Diego, Calif.) 1994;25():1-20.
1994: Turnbull A V; Dow R C; Hopkins S J; White A; Fink G; Rothwell N J
Mechanisms of activation of the pituitary-adrenal axis by tissue injury in the rat.
Psychoneuroendocrinology 1994;19(2):165-78.
1993: Rothwell N J
Cytokines and thermogenesis.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1993;17 Suppl 3():S98-101; discussion 115.
1993: Derijk R H; Strijbos P J; van Rooijen N; Rothwell N J; Berkenbosch F
Fever and thermogenesis in response to bacterial endotoxin involve macrophage-dependent mechanisms in rats.
The American journal of physiology 1993;265(5 Pt 2):R1179-83.
1993: Luheshi G; Hopkins S J; Lefeuvre R A; Dascombe M J; Ghiara P; Rothwell N J
Importance of brain IL-1 type II receptors in fever and thermogenesis in the rat.
The American journal of physiology 1993;265(4 Pt 1):E585-91.
1993: Cooper A L; Rothwell N J
Inhibition of the thermogenic and pyrogenic responses to interleukin-1 beta in the rat by dietary N-3 fatty acid supplementation.
Prostaglandins, leukotrienes, and essential fatty acids 1993;49(2):615-26.
1993: Strijbos P J; Horan M A; Carey F; Rothwell N J
Impaired febrile responses of aging mice are mediated by endogenous lipocortin-1 (annexin-1).
The American journal of physiology 1993;265(2 Pt 1):E289-97.
1993: Turnbull A V; Kirkman E; Rothwell N J; Little R A
The neuropeptide CRF is involved in the modulation of the baroreflex during hindlimb ischaemia in the anaesthetized rat.
The Journal of physiology 1993;468():529-41.
1993: Coelho M M; Pelá I R; Rothwell N J
Dexamethasone inhibits the pyrogenic activity of prostaglandin F2 alpha, but not prostaglandin E2.
European journal of pharmacology 1993;238(2-3):391-4.
1993: Busbridge N J; Dascombe M J; Rothwell N J
Chronic effects of interleukin-1 beta on fever, oxygen consumption and food intake in the rat.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1993;25(4):222-7.
1993: Martineau L; Little R A; Rothwell N J; Fisher M I
Clenbuterol, a beta 2-adrenergic agonist, reverses muscle wasting due to scald injury in the rat.
Burns : journal of the International Society for Burn Injuries 1993;19(1):26-34.
1993: Rothwell N J; Relton J K
Involvement of cytokines in acute neurodegeneration in the CNS.
Neuroscience and biobehavioral reviews 1993;17(2):217-27.
1993: Relton J K; Strijbos P J; Cooper A L; Rothwell N J
Dietary N-3 fatty acids inhibit ischaemic and excitotoxic brain damage in the rat.
Brain research bulletin 1993;32(3):223-6.
1993: Rothwell N J; Relton J K
Involvement of interleukin-1 and lipocortin-1 in ischaemic brain damage.
Cerebrovascular and brain metabolism reviews 1993;5(3):178-98.
1992: Rothwell N J; Le Feuvre R A
Thermogenesis, brown adipose tissue and dexfenfluramine in animal studies.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1992;16 Suppl 3():S67-71.
1992: Martineau L; Horan M A; Rothwell N J; Little R A
Salbutamol, a beta 2-adrenoceptor agonist, increases skeletal muscle strength in young men.
Clinical science (London, England : 1979) 1992;83(5):615-21.
1992: Strijbos P J; Hardwick A J; Relton J K; Carey F; Rothwell N J
Inhibition of central actions of cytokines on fever and thermogenesis by lipocortin-1 involves CRF.
The American journal of physiology 1992;263(4 Pt 1):E632-6.
1992: Martineau L; Horan M A; Rothwell N J; Little R A
Muscling in on salbutamol.
Lancet 1992;340(8827):1094.
1992: Relton J K; Rothwell N J
Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat.
Brain research bulletin 1992;29(2):243-6.
1992: Black M D; Carey F; Crossman A R; Relton J K; Rothwell N J
Lipocortin-1 inhibits NMDA receptor-mediated neuronal damage in the striatum of the rat.
Brain research 1992;585(1-2):135-40.
1992: Choo J J; Horan M A; Little R A; Rothwell N J
Anabolic effects of clenbuterol on skeletal muscle are mediated by beta 2-adrenoceptor activation.
The American journal of physiology 1992;263(1 Pt 1):E50-6.
1992: Cooper A L; Horan M A; Little R A; Rothwell N J
Metabolic and febrile responses to typhoid vaccine in humans: effect of beta-adrenergic blockade.
Journal of applied physiology (Bethesda, Md. : 1985) 1992;72(6):2322-8.
1992: Rothwell N J
Eicosanoids, thermogenesis and thermoregulation.
Prostaglandins, leukotrienes, and essential fatty acids 1992;46(1):1-7.
1992: Rothwell N J; Flower R
Lipocortin-1 exhibits novel actions, providing clinical opportunities.
Trends in pharmacological sciences 1992;13(2):45-6.
1991: Cooper A L; Rothwell N J
Mechanisms of early and late hypermetabolism and fever after localized tissue injury in rats.
The American journal of physiology 1991;261(6 Pt 1):E698-705.
1991: Rothwell N J
Functions and mechanisms of interleukin 1 in the brain.
Trends in pharmacological sciences 1991;12(11):430-6.
1991: Rothwell N J; Busbridge N J; Lefeuvre R A; Hardwick A J; Gauldie J; Hopkins S J
Interleukin-6 is a centrally acting endogenous pyrogen in the rat.
Canadian journal of physiology and pharmacology 1991;69(10):1465-9.
1991: Le Feuvre R A; Aisenthal L; Rothwell N J
Involvement of corticotrophin releasing factor (CRF) in the thermogenic and anorexic actions of serotonin (5-HT) and related compounds.
Brain research 1991;555(2):245-50.
1991: Relton J K; Strijbos P J; O'Shaughnessy C T; Carey F; Forder R A; Tilders F J; Rothwell N J
Lipocortin-1 is an endogenous inhibitor of ischemic damage in the rat brain.
The Journal of experimental medicine 1991;174(2):305-10.
1991: Strijbos P J; Tilders F J; Carey F; Forder R; Rothwell N J
Localization of immunoreactive lipocortin-1 in the brain and pituitary gland of the rat. Effects of adrenalectomy, dexamethasone and colchicine treatment.
Brain research 1991;553(2):249-60.
1991: Le Feuvre R A; Woods A J; Stock M J; Rothwell N J
Effects of central injection of glucose on thermogenesis in normal, VMH-lesioned and genetically obese rats.
Brain research 1991;547(1):110-4.
1991: Rothwell N J; Hardwick A; LeFeuvre R A; Crosby S R; White A
Central actions of CRF on thermogenesis are mediated by pro-opiomelanocortin products.
Brain research 1991;541(1):89-92.
1991: Rothwell N J
The endocrine significance of cytokines.
The Journal of endocrinology 1991;128(2):171-3.
1991: Rothwell N J; Little R A; Rose J G
Brown adipose tissue activity and oxygen consumption after scald injury in the rat.
Circulatory shock 1991;33(1):33-6.
1990: Strijbos P; Tilders F; Carey F; Forder R; Rothwell N
Localization of lipocortin-1 in normal rat brain.
Biochemical Society transactions 1990;18(6):1234-5.
1990: Rothwell N J
Central activation of thermogenesis by prostaglandins: dependence on CRF.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1990;22(12):616-8.
1990: Rothwell N J; Hardwick A J; Lindley I
Central actions of interleukin-8 in the rat are independent of prostaglandins.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1990;22(11):595-6.
1990: Rothwell N J
Mechanisms of the pyrogenic actions of cytokines.
European cytokine network 1990;1(4):211-3.
1990: O'Shaughnessy C T; Rothwell N J; Shrewsbury-Gee J
Sympathetically mediated hypermetabolic response to cerebral ischemia in the rat.
Canadian journal of physiology and pharmacology 1990;68(10):1334-7.
1990: Choo J J; Horan M A; Little R A; Rothwell N J; Wareham A
Anabolic beta-2-agonist clenbuterol fails to modify muscle atrophy due to femur fracture.
Circulatory shock 1990;32(2):165-71.
1990: Busbridge N J; Carnie J A; Dascombe M J; Johnston J A; Rothwell N J
Adrenalectomy reverses the impaired pyrogenic responses to interleukin-beta in obese Zucker rats.
International journal of obesity 1990;14(9):809-14.
1990: Arnold J; Choo J J; Little R A; Rothwell N J
Dopamine beta-hydroxylase inhibition reveals a selective influence of endotoxin on catecholamine content of rat tissues.
Circulatory shock 1990;31(4):387-94.
1990: Carey F; Forder R; Edge M D; Greene A R; Horan M A; Strijbos P J; Rothwell N J
Lipocortin 1 fragment modifies pyrogenic actions of cytokines in rats.
The American journal of physiology 1990;259(2 Pt 2):R266-9.
1990: Choo J J; Horan M A; Little R A; Rothwell N J
Effects of the beta 2-adrenoceptor agonist, clenbuterol, on muscle atrophy due to food deprivation in the rat.
Metabolism: clinical and experimental 1990;39(6):647-50.
1990: Rothwell N J
Central effects of CRF on metabolism and energy balance.
Neuroscience and biobehavioral reviews 1990;14(3):263-71.
1989: McCarthy H D; O'Shaughnessy C T; Rothwell N J
Endogenous mediators of cerebral ischaemia-induced hypermetabolism in the rat.
British journal of pharmacology 1989;98 Suppl():838P.
1989: Bianchi A; Bruce J; Cooper A L; Childs C; Kohli M; Morris I D; Morris-Jones P; Rothwell N J
Increased brown adipose tissue activity in children with malignant disease.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1989;21(11):640-1.
1989: Choo J J; Horan M A; Little R A; Rothwell N J
Muscle wasting associated with endotoxemia in the rat: modification by the beta 2-adrenoceptor agonist clenbuterol.
Bioscience reports 1989;9(5):615-21.
1989: O'Shaughnessy C T; Rothwell N J; Shrewsbury-Gee J
Effects of an analogue of thyrotrophin-releasing hormone, RX77368, on infarct size and cerebral blood flow in focal cerebral ischaemia in the rat.
Canadian journal of physiology and pharmacology 1989;67(10):1345-50.
1989: Cooper A L; Dascombe M J; Rothwell N J; Vale M J
Effects of malaria on O2 consumption and brown adipose tissue activity in mice.
Journal of applied physiology (Bethesda, Md. : 1985) 1989;67(3):1020-3.
1989: Horan M A; Little R A; Rothwell N J; Strijbos P J
Comparison of the effects of several endotoxin preparations on body temperature and metabolic rate in the rat.
Canadian journal of physiology and pharmacology 1989;67(9):1011-4.
1989: Le Feuvre R A; Rothwell N J; White A
A comparison of the thermogenic effects of CRF, sauvagine and urotensin I in the rat.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1989;21(9):525-6.
1989: Busbridge N J; Dascombe M J; Tilders F J; van Oers J W; Linton E A; Rothwell N J
Central activation of thermogenesis and fever by interleukin-1 beta and interleukin-1 alpha involves different mechanisms.
Biochemical and biophysical research communications 1989;162(2):591-6.
1989: Rothwell N J
Central control of brown adipose tissue.
The Proceedings of the Nutrition Society 1989;48(2):197-206.
1989: Hardwick A J; Linton E A; Rothwell N J
Thermogenic effects of the antiglucocorticoid RU-486 in the rat: involvement of corticotropin-releasing factor and sympathetic activation of brown adipose tissue.
Endocrinology 1989;124(4):1684-8.
1989: Dascombe M J; Rothwell N J; Sagay B O; Stock M J
Pyrogenic and thermogenic effects of interleukin 1 beta in the rat.
The American journal of physiology 1989;256(1 Pt 1):E7-11.
1989: Rothwell N J
CRF is involved in the pyrogenic and thermogenic effects of interleukin 1 beta in the rat.
The American journal of physiology 1989;256(1 Pt 1):E111-5.
1989: Dascombe M J; Hardwick A; Lefeuvre R A; Rothwell N J
Impaired effects of interleukin-1 beta on fever and thermogenesis in genetically obese rats.
International journal of obesity 1989;13(3):367-73.
1989: Cooper A L; Fitzgeorge R B; Baskerville A; Little R A; Rothwell N J
Bacterial infection (Legionella pneumophila) stimulates fever, metabolic rate and brown adipose tissue activity in the guinea pig.
Life sciences 1989;45(9):843-7.
1988: Rothwell N J; Stock M J
Brown adipose tissue: does it play a role in the development of obesity?
Diabetes/metabolism reviews 1988;4(6):595-601.
1988: Rothwell N J
Central effects of TNF alpha on thermogenesis and fever in the rat.
Bioscience reports 1988;8(4):345-52.
1988: Griffiths E C; Rothwell N J; Stock M J
Thermogenic effects of thyrotrophin-releasing hormone and its analogues in the rat.
Experientia 1988;44(1):40-2.
1988: Rothwell N J; Stock M J
Insulin and thermogenesis.
International journal of obesity 1988;12(2):93-102.
1988: Horan M A; Little R A; Rothwell N J; Stock M J
Changes in body composition, brown adipose tissue activity and thermogenic capacity in BN/BiRij rats undergoing senescence.
Experimental gerontology 1988;23(6):455-61.

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