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Nancy Rothwell

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Sylvie Girard; Gloria Lopez-Castejon; Nancy J Rothwell; David Brough; James Giles; Stuart M Allan
Microglia and macrophages differentially modulate cell death after brain injury caused by oxygen-glucose deprivation in organotypic brain slices.
Herve Boutin; Gavin Brown; Christopher Cawthorne; James Galea; Andrew D Greenhalgh; Karl Herholz; Peter Julyan; Michael Kassiou; Renaud Maroy; Christian Prenant; Alison Smigova; Shane M Wilkinson; Samuel D Banister; Nancy J Rothwell
[18F]DPA-714: direct comparison with [11C]PK11195 in a model of cerebral ischemia in rats.
Andrew D Greenhalgh; Emily M Robinson; Nancy J Rothwell; David Brough; Sylvie Girard; Stuart M Allan
Interleukin-1 receptor antagonist is beneficial after subarachnoid haemorrhage in rat by blocking haem-driven inflammatory pathology.

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All Publications

2013: Sylvie Girard; Gloria Lopez-Castejon; Nancy J Rothwell; David Brough; James Giles; Stuart M Allan
Microglia and macrophages differentially modulate cell death after brain injury caused by oxygen-glucose deprivation in organotypic brain slices.
Glia 2013;61(5):813-24.
2013: Herve Boutin; Gavin Brown; Christopher Cawthorne; James Galea; Andrew D Greenhalgh; Karl Herholz; Peter Julyan; Michael Kassiou; Renaud Maroy; Christian Prenant; Alison Smigova; Shane M Wilkinson; Samuel D Banister; Nancy J Rothwell
[18F]DPA-714: direct comparison with [11C]PK11195 in a model of cerebral ischemia in rats.
PloS one 2013;8(2):e56441.
2012: Andrew D Greenhalgh; Emily M Robinson; Nancy J Rothwell; David Brough; Sylvie Girard; Stuart M Allan
Interleukin-1 receptor antagonist is beneficial after subarachnoid haemorrhage in rat by blocking haem-driven inflammatory pathology.
Disease models & mechanisms 2012;5(6):823-33.
2012: Carina A Cantrill; Nancy J Rothwell; Robert A Skinner; Jeffrey I Penny
An immortalised astrocyte cell line maintains the in vivo phenotype of a primary porcine in vitro blood-brain barrier model.
Brain research 2012;1479():17-30.
2012: Jesus M Pradillo; Spencer D Proctor; Nancy J Rothwell; James C Russell; Eleanor Barton; Herve Boutin; Adam Denes; Caroline Drake; Andrew D Greenhalgh; Barry W McColl; Stuart M Allan
Delayed administration of interleukin-1 receptor antagonist reduces ischemic brain damage and inflammation in comorbid rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2012;32(9):1810-9.
2012: Charlotte Allen; Adam Denes; Barry W McColl; Marc Monestier; Adam Pierozynski; Emmanuel Pinteaux; Nancy J Rothwell; Peter Thornton; Stuart M Allan
Neutrophil cerebrovascular transmigration triggers rapid neurotoxicity through release of proteases associated with decondensed DNA.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(1):381-92.
2012: Adam Denes; Caroline Drake; Sheila Francis; Hermann Gram; Barry W McColl; Stuart M Allan; Janet Chamberlain; David Crossman; Jing Stordy; Nancy J Rothwell
Interleukin-1 mediates neuroinflammatory changes associated with diet-induced atherosclerosis.
Journal of the American Heart Association 2012;1(3):e002006.
2012: Craig J Smith; Pippa J Tyrrell; Chinedu T Udeh; Andy Vail; Hedley C A Emsley; Margaret E Hoadley; Nancy J Rothwell; Stephen J Hopkins
Interleukin-1 receptor antagonist reverses stroke-associated peripheral immune suppression.
Cytokine 2012;58(3):384-9.
2012: Stephen J Hopkins; Sharon Hulme; Andrew T King; Catherine J McMahon; Hiren Patel; Nancy J Rothwell; Sylvia Scarth; Navneet Singh; James Galea; Margaret E Hoadley; Andy Vail; Pippa J Tyrrell
Cerebrospinal fluid and plasma cytokines after subarachnoid haemorrhage: CSF interleukin-6 may be an early marker of infection.
Journal of neuroinflammation 2012;9():255.
2012: Sophie Leow-Dyke; Samaneh Maysami; Olov Nilsson; Charlotte Allen; Andrew G Bowie; Adam Denes; Nancy J Rothwell; Emmanuel Pinteaux
Neuronal toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro.
Journal of neuroinflammation 2012;9():230.
2011: Ben G Small; Richard Allmendinger; David Brough; Joshua Knowles; Gloria López-Castejón; Barry W McColl; Pedro Mendes; Jürgen Pahle; Nancy J Rothwell; Douglas B Kell
Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing.
Nature chemical biology 2011;7(12):902-8.
2011: Caroline Drake; Sheila Francis; Rachel F Georgiou; Alexander Gerhard; Karl Herholz; Rainer Hinz; Stephen J Hopkins; Sharon Hulme; Matthew S Jones; Peter Julyan; Michael Kassiou; Renaud Maroy; Barry W McColl; Christian Prenant; Spencer D Proctor; Nancy J Rothwell; James C Russell; Johann R Selvarajah; Alison Smigova; Pippa J Tyrrell; Andy Vail; Herve Boutin; Gavin Brown; David Crossman; Adam Denes; Stuart M Allan
Brain inflammation is induced by co-morbidities and risk factors for stroke.
Brain, behavior, and immunity 2011;25(6):1113-22.
2011: Johann R Selvarajah; Craig J Smith; Sharon Hulme; Rachel Georgiou; Charles Sherrington; John Staniland; Karen J Illingworth; Francine Jury; Antony Payton; William E Ollier; Andy Vail; Nancy J Rothwell; Stephen J Hopkins; Philippa J Tyrrell
Does inflammation predispose to recurrent vascular events after recent transient ischaemic attack and minor stroke? The North West of England transient ischaemic attack and minor stroke (NORTHSTAR) study.
International journal of stroke : official journal of the International Stroke Society 2011;6(3):187-94.
2011: Adam Denes; Barry W McColl; Sophie F Leow-Dyke; Katie Z Chapman; Neil E Humphreys; Richard K Grencis; Stuart M Allan; Nancy J Rothwell
Experimental stroke-induced changes in the bone marrow reveal complex regulation of leukocyte responses.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2011;31(4):1036-50.
2011: Christopher Cawthorne; C Prenant; A Smigova; Peter Julyan; R Maroy; K Herholz; Nancy J Rothwell; Herve Boutin
Biodistribution, pharmacokinetics and metabolism of interleukin-1 receptor antagonist (IL-1RA) using [¹⁸F]-IL1RA and PET imaging in rats.
British journal of pharmacology 2011;162(3):659-72.
2010: Peter Thornton; Barry W McColl; Laura Cooper; Nancy J Rothwell; Stuart M Allan
Interleukin-1 drives cerebrovascular inflammation via MAP kinase-independent pathways.
Current neurovascular research 2010;7(4):330-40.
2010: C Prenant; Christopher Cawthorne; M Fairclough; Nancy J Rothwell; Herve Boutin
Radiolabeling with fluorine-18 of a protein, interleukin-1 receptor antagonist.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2010;68(9):1721-7.
2010: A Denes; P Thornton; Nancy J Rothwell; S M Allan
Inflammation and brain injury: acute cerebral ischaemia, peripheral and central inflammation.
Brain, behavior, and immunity 2010;24(5):708-23.
2010: Peter Thornton; Barry W McColl; Andrew Greenhalgh; Adam Denes; Stuart M Allan; Nancy J Rothwell
Platelet interleukin-1alpha drives cerebrovascular inflammation.
Blood 2010;115(17):3632-9.
2010: Barry W McColl; Nicola Rose; Fiona H Robson; Nancy J Rothwell; Catherine B Lawrence
Increased brain microvascular MMP-9 and incidence of haemorrhagic transformation in obese mice after experimental stroke.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2010;30(2):267-72.
2009: Katie Z Chapman; Verity Q Dale; Adám Dénes; Gavin Bennett; Nancy J Rothwell; Stuart M Allan; Barry W McColl
A rapid and transient peripheral inflammatory response precedes brain inflammation after experimental stroke.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2009;29(11):1764-8.
2009: N M Luheshi; Nancy J Rothwell; David Brough
Dual functionality of interleukin-1 family cytokines: implications for anti-interleukin-1 therapy.
British journal of pharmacology 2009;157(8):1318-29.
2009: R A Skinner; Rosemary M Gibson; Nancy J Rothwell; Emmanuel Pinteaux; J I Penny
Transport of interleukin-1 across cerebromicrovascular endothelial cells.
British journal of pharmacology 2009;156(7):1115-23.
2009: Barry W McColl; S M Allan; Nancy J Rothwell
Systemic infection, inflammation and acute ischemic stroke.
Neuroscience 2009;158(3):1049-61.
2009: David Brough; Pablo Pelegrin; Nancy J Rothwell
Pannexin-1-dependent caspase-1 activation and secretion of IL-1beta is regulated by zinc.
European journal of immunology 2009;39(2):352-8.
2009: Nadia M Luheshi; Nancy J Rothwell; David Brough
The dynamics and mechanisms of interleukin-1alpha and beta nuclear import.
Traffic (Copenhagen, Denmark) 2009;10(1):16-25.
2008: Penglian Wang; Nancy J Rothwell; Emmanuel Pinteaux; David Brough
Neuronal injury induces the release of pro-interleukin-1beta from activated microglia in vitro.
Brain research 2008;1236():1-7.
2008: Barry W McColl; Nancy J Rothwell; Stuart M Allan
Systemic inflammation alters the kinetics of cerebrovascular tight junction disruption after experimental stroke in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(38):9451-62.
2008: Niki Tsakiri; Ian Kimber; Nancy J Rothwell; Emmanuel Pinteaux
Differential effects of interleukin-1 alpha and beta on interleukin-6 and chemokine synthesis in neurones.
Molecular and cellular neurosciences 2008;38(2):259-65.
2008: Adrian R Parry-Jones; Timo Liimatainen; Risto A Kauppinen; Olli H J Gröhn; Nancy J Rothwell
Interleukin-1 exacerbates focal cerebral ischemia and reduces ischemic brain temperature in the rat.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2008;59(6):1239-49.
2008: Ivelina Gueorguieva; Simon R Clark; Catherine J McMahon; Sylvia Scarth; Nancy J Rothwell; Pippa J Tyrrell; Pippa J Tyrell; Stephen J Hopkins; Malcolm Rowland
Pharmacokinetic modelling of interleukin-1 receptor antagonist in plasma and cerebrospinal fluid of patients following subarachnoid haemorrhage.
British journal of clinical pharmacology 2008;65(3):317-25.
2008: N Tsakiri; Ian Kimber; Nancy J Rothwell; Emmanuel Pinteaux
Interleukin-1-induced interleukin-6 synthesis is mediated by the neutral sphingomyelinase/Src kinase pathway in neurones.
British journal of pharmacology 2008;153(4):775-83.
2008: Simon R Clark; Catherine J McMahon; Iva Gueorguieva; Malcolm Rowland; Sylvia Scarth; Rachel Georgiou; Pippa J Tyrrell; Stephen J Hopkins; Nancy J Rothwell
Interleukin-1 receptor antagonist penetrates human brain at experimentally therapeutic concentrations.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2008;28(2):387-94.
2008: Peter Thornton; Emmanuel Pinteaux; Stuart M Allan; Nancy J Rothwell
Matrix metalloproteinase-9 and urokinase plasminogen activator mediate interleukin-1-induced neurotoxicity.
Molecular and cellular neurosciences 2008;37(1):135-42.
2008: Niki Tsakiri; Ian Kimber; Nancy J Rothwell; Emmanuel Pinteaux
Mechanisms of interleukin-6 synthesis and release induced by interleukin-1 and cell depolarisation in neurones.
Molecular and cellular neurosciences 2008;37(1):110-8.
2007: Barry W McColl; Stuart M Allan; Nancy J Rothwell
Systemic inflammation and stroke: aetiology, pathology and targets for therapy.
Biochemical Society transactions 2007;35(Pt 5):1163-5.
2007: Jerard Ross; David Brough; Rosemary M Gibson; Sarah A Loddick; Nancy J Rothwell
A selective, non-peptide caspase-1 inhibitor, VRT-018858, markedly reduces brain damage induced by transient ischemia in the rat.
Neuropharmacology 2007;53(5):638-42.
2007: Emmanuel Pinteaux; Wataru Inoue; Lorraine Schmidt; Francisco Molina-Holgado; Nancy J Rothwell; Giamal N Luheshi
Leptin induces interleukin-1beta release from rat microglial cells through a caspase 1 independent mechanism.
Journal of neurochemistry 2007;102(3):826-33.
2007: Barry W McColl; Nancy J Rothwell; Stuart M Allan
Systemic inflammatory stimulus potentiates the acute phase and CXC chemokine responses to experimental stroke and exacerbates brain damage via interleukin-1- and neutrophil-dependent mechanisms.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(16):4403-12.
2007: David Brough; Nancy J Rothwell
Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death.
Journal of cell science 2007;120(Pt 5):772-81.
2007: Sinead M Miggin; Eva M Pålsson-McDermott; Aisling Dunne; Caroline Jefferies; Emmanuel Pinteaux; Kathy Banahan; Caroline Murphy; Paul N Moynagh; Masahiro Yamamoto; Shizuo Akira; Nancy J Rothwell; Douglas T Golenbock; Katherine A Fitzgerald; Luke A J O'Neill
NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3372-7.
2007: P Marc D Watson; Martin J Humphries; Jane Relton; Nancy J Rothwell; Alexei Verkhratsky; Rosemary M Gibson
Integrin-binding RGD peptides induce rapid intracellular calcium increases and MAPK signaling in cortical neurons.
Molecular and cellular neurosciences 2007;34(2):147-54.
2007: Hedley C A Emsley; Craig J Smith; Carole M Gavin; Rachel F Georgiou; Andy Vail; Elisa M Barberan; Karen Illingworth; Sylvia Scarth; Vijitha Wickramasinghe; Margaret E Hoadley; Nancy J Rothwell; Pippa J Tyrrell; Stephen J Hopkins
Clinical outcome following acute ischaemic stroke relates to both activation and autoregulatory inhibition of cytokine production.
BMC neurology 2007;7():5.
2006: Craig J Smith; Hedley C A Emsley; Andy Vail; Rachel F Georgiou; Nancy J Rothwell; Pippa J Tyrrell; Stephen J Hopkins
Variability of the systemic acute phase response after ischemic stroke.
Journal of the neurological sciences 2006;251(1-2):77-81.
2006: Robert Skinner; Rachel Georgiou; Peter Thornton; Nancy J Rothwell
Psychoneuroimmunology of stroke.
Neurologic clinics 2006;24(3):561-83.
2006: Peter Thornton; Emmanuel Pinteaux; Rosemary M Gibson; Stuart M Allan; Nancy J Rothwell
Interleukin-1-induced neurotoxicity is mediated by glia and requires caspase activation and free radical release.
Journal of neurochemistry 2006;98(1):258-66.
2006: Emmanuel Pinteaux; Nancy J Rothwell; Herve Boutin
Neuroprotective actions of endogenous interleukin-1 receptor antagonist (IL-1ra) are mediated by glia.
Glia 2006;53(5):551-6.
2006: Ralph Andre; Jonathan G Moggs; Ian Kimber; Nancy J Rothwell; Emmanuel Pinteaux
Gene regulation by IL-1beta independent of IL-1R1 in the mouse brain.
Glia 2006;53(5):477-83.
2006: H C Patel; F M Ross; Laura Heenan; R E Davies; Nancy J Rothwell; Stuart M Allan
Neurodegenerative actions of interleukin-1 in the rat brain are mediated through increases in seizure activity.
Journal of neuroscience research 2006;83(3):385-91.
2006: Sian-Marie Lucas; Nancy J Rothwell; Rosemary M Gibson
The role of inflammation in CNS injury and disease.
British journal of pharmacology 2006;147 Suppl 1():S232-40.
2005: Hedley C A Emsley; Craig J Smith; Rachel F Georgiou; Andy Vail; Stephen J Hopkins; Nancy J Rothwell; Pippa J Tyrrell
A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients.
Journal of neurology, neurosurgery, and psychiatry 2005;76(10):1366-72.
2005: Ralph Andre; Dominique Lerouet; Ian Kimber; Emmanuel Pinteaux; Nancy J Rothwell
Regulation of expression of the novel IL-1 receptor family members in the mouse brain.
Journal of neurochemistry 2005;95(2):324-30.
2005: Stuart M Allan; Pippa J Tyrrell; Nancy J Rothwell
Interleukin-1 and neuronal injury.
Nature reviews. Immunology 2005;5(8):629-40.
2005: Penglian Wang; Brenda Meinhardt; Ralph Andre; Blair R Renshaw; Ian Kimber; Nancy J Rothwell; Emmanuel Pinteaux
The interleukin-1-related cytokine IL-1F8 is expressed in glial cells, but fails to induce IL-1beta signalling responses.
Cytokine 2005;29(6):245-50.
2005: Ralph Andre; Emmanuel Pinteaux; Ian Kimber; Nancy J Rothwell
Differential actions of IL-1 alpha and IL-1 beta in glial cells share common IL-1 signalling pathways.
Neuroreport 2005;16(2):153-7.
2005: Hedley C A Emsley; Craig J Smith; Rachel F Georgiou; Andy Vail; Pippa J Tyrrell; Elisa M Barberan; Nancy J Rothwell; Stephen J Hopkins
Correlation of systemic inflammatory response with infarct volume in acute ischemic stroke patients.
Stroke; a journal of cerebral circulation 2005;36(2):228-9; author reply 228-9.
2005: Francisco Molina-Holgado; Emmanuel Pinteaux; Laura Heenan; Jonathan D Moore; Nancy J Rothwell; Rosemary M Gibson
Neuroprotective effects of the synthetic cannabinoid HU-210 in primary cortical neurons are mediated by phosphatidylinositol 3-kinase/AKT signaling.
Molecular and cellular neurosciences 2005;28(1):189-94.
2004: Rosemary M Gibson; Nancy J Rothwell; Rosalind A Le Feuvre
CNS injury: the role of the cytokine IL-1.
Veterinary journal (London, England : 1997) 2004;168(3):230-7.
2004: Nancy J Rothwell
One more thing...
Nature 2004;427(6976):683.
2004: Craig J Smith; Hedley C A Emsley; Carole M Gavin; Rachel F Georgiou; Andy Vail; Elisa M Barberan; Gregory J del Zoppo; John M Hallenbeck; Nancy J Rothwell; Stephen J Hopkins; Pippa J Tyrrell
Peak plasma interleukin-6 and other peripheral markers of inflammation in the first week of ischaemic stroke correlate with brain infarct volume, stroke severity and long-term outcome.
BMC neurology 2004;4():2.
2003: Ralph Andre; Rachel D Wheeler; Peter D Collins; Giamal N Luheshi; Stuart Pickering-Brown; Ian Kimber; Nancy J Rothwell; Emmanuel Pinteaux
Identification of a truncated IL-18R beta mRNA: a putative regulator of IL-18 expressed in rat brain.
Journal of neuroimmunology 2003;145(1-2):40-5.
2003: Fiona M Ross; Stuart M Allan; Nancy J Rothwell; Alexei Verkhratsky
A dual role for interleukin-1 in LTP in mouse hippocampal slices.
Journal of neuroimmunology 2003;144(1-2):61-7.
2003: Stuart M Allan; Nancy J Rothwell
Inflammation in central nervous system injury.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2003;358(1438):1669-77.
2003: Nicholas J Mulcahy; Jerard Ross; Nancy J Rothwell; Sarah A Loddick
Delayed administration of interleukin-1 receptor antagonist protects against transient cerebral ischaemia in the rat.
British journal of pharmacology 2003;140(3):471-6.
2003: Francisco Molina-Holgado; Emmanuel Pinteaux; Jonathan D Moore; Eduardo Molina-Holgado; Carmen Guaza; Rosemary M Gibson; Nancy J Rothwell
Endogenous interleukin-1 receptor antagonist mediates anti-inflammatory and neuroprotective actions of cannabinoids in neurons and glia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(16):6470-4.
2003: Herve Boutin; Ian Kimber; Nancy J Rothwell; Emmanuel Pinteaux
The expanding interleukin-1 family and its receptors: do alternative IL-1 receptor/signaling pathways exist in the brain?
Molecular neurobiology 2003;27(3):239-48.
2003: Hedley C A Emsley; Craig J Smith; Carole M Gavin; Rachel F Georgiou; Andy Vail; Elisa M Barberan; John M Hallenbeck; Gregory J del Zoppo; Nancy J Rothwell; Pippa J Tyrrell; Stephen J Hopkins
An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosis.
Journal of neuroimmunology 2003;139(1-2):93-101.
2003: Elisabet Berglöf; Ralph Andre; Blair R Renshaw; Stuart M Allan; Catherine B Lawrence; Nancy J Rothwell; Emmanuel Pinteaux
IL-1Rrp2 expression and IL-1F9 (IL-1H1) actions in brain cells.
Journal of neuroimmunology 2003;139(1-2):36-43.
2003: Rachel D Wheeler; David Brough; Rosalind A Le Feuvre; Kiyoshi Takeda; Yoichiro Iwakura; Giamal N Luheshi; Nancy J Rothwell
Interleukin-18 induces expression and release of cytokines from murine glial cells: interactions with interleukin-1 beta.
Journal of neurochemistry 2003;85(6):1412-20.
2003: Nancy J Rothwell
Interleukin-1 and neuronal injury: mechanisms, modification, and therapeutic potential.
Brain, behavior, and immunity 2003;17(3):152-7.
2003: Rachel D Wheeler; Herve Boutin; Omar Touzani; Giamal N Luheshi; Kiyoshi Takeda; Nancy J Rothwell
No role for interleukin-18 in acute murine stroke-induced brain injury.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2003;23(5):531-5.
2003: David Brough; Rosalind A Le Feuvre; Rachel D Wheeler; Natasha Solovyova; Sabine Hilfiker; Nancy J Rothwell; Alexei Verkhratsky
Ca2+ stores and Ca2+ entry differentially contribute to the release of IL-1 beta and IL-1 alpha from murine macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(6):3029-36.
2003: Rosalind A Le Feuvre; David Brough; Omar Touzani; Nancy J Rothwell
Role of P2X7 receptors in ischemic and excitotoxic brain injury in vivo.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2003;23(3):381-4.
2003: Rachel D Wheeler; Elizabeth A Young; Nancy J Rothwell; Matthew D Hall; Giamal N Luheshi
Up-regulation of IL-18BP, but not IL-18 mRNA in rat liver by LPS.
Cytokine 2003;21(4):161-6.
2002: Emmanuel Pinteaux; Lisa C Parker; Nancy J Rothwell; Giamal N Luheshi
Expression of interleukin-1 receptors and their role in interleukin-1 actions in murine microglial cells.
Journal of neurochemistry 2002;83(4):754-63.
2002: Elizabeth Oakden; Malcolm Chiswick; Nancy J Rothwell; Sarah A Loddick
The influence of litter size on brain damage caused by hypoxic-ischemic injury in the neonatal rat.
Pediatric research 2002;52(5):692-6.
2002: Rosalind A Le Feuvre; David Brough; Nancy J Rothwell
Extracellular ATP and P2X7 receptors in neurodegeneration.
European journal of pharmacology 2002;447(2-3):261-9.
2002: Lisa C Parker; Giamal N Luheshi; Nancy J Rothwell; Emmanuel Pinteaux
IL-1 beta signalling in glial cells in wildtype and IL-1RI deficient mice.
British journal of pharmacology 2002;136(2):312-20.
2002: Francisco Molina-Holgado; Eduardo Molina-Holgado; Carmen Guaza; Nancy J Rothwell
Role of CB1 and CB2 receptors in the inhibitory effects of cannabinoids on lipopolysaccharide-induced nitric oxide release in astrocyte cultures.
Journal of neuroscience research 2002;67(6):829-36.
2002: Jonathan D Moore; Nancy J Rothwell; Rosemary M Gibson
Involvement of caspases and calpains in cerebrocortical neuronal cell death is stimulus-dependent.
British journal of pharmacology 2002;135(4):1069-77.
2002: David Brough; Rosalind A Le Feuvre; Yoichiro Iwakura; Nancy J Rothwell
Purinergic (P2X7) receptor activation of microglia induces cell death via an interleukin-1-independent mechanism.
Molecular and cellular neurosciences 2002;19(2):272-80.
2002: Robert Grundy; Nancy J Rothwell; Stuart M Allan
Site-specific actions of interleukin-1 on excitotoxic cell death in the rat striatum.
Brain research 2002;926(1-2):142-8.
2002: Kate L J Ellacott; Catherine B Lawrence; Nancy J Rothwell; Simon M Luckman
PRL-releasing peptide interacts with leptin to reduce food intake and body weight.
Endocrinology 2002;143(2):368-74.
2002: Rosalind A Le Feuvre; David Brough; Yoichiro Iwakura; Kiyoshi Takeda; Nancy J Rothwell
Priming of macrophages with lipopolysaccharide potentiates P2X7-mediated cell death via a caspase-1-dependent mechanism, independently of cytokine production.
The Journal of biological chemistry 2002;277(5):3210-8.
2002: Omar Touzani; Herve Boutin; Rosalind LeFeuvre; Lisa Parker; Andy Miller; Giamal N Luheshi; Nancy J Rothwell
Interleukin-1 influences ischemic brain damage in the mouse independently of the interleukin-1 type I receptor.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(1):38-43.
2001: Stuart M Allan; Nancy J Rothwell
Cytokines and acute neurodegeneration.
Nature reviews. Neuroscience 2001;2(10):734-44.
2001: Stuart M Allan; David C Harrison; S Read; B Collins; Andrew A Parsons; KL Philpott; Nancy J Rothwell
Selective increases in cytokine expression in the rat brain in response to striatal injection of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate and interleukin-1.
Brain research. Molecular brain research 2001;93(2):180-9.
2001: MW Craighead; K M Middlehurst; Rosalind LeFeuvre; Ian Kimber; Nancy J Rothwell
Oxidised adenosine 5'-triphosphate, a P2X(7) antagonist, is toxic to rat cerebellar granule neurones in vitro.
Neuroscience letters 2001;311(2):77-80.
2001: Nancy J Rothwell
Thermogenesis: where are we and where are we going? Report of a workshop held in London 21st April 2001, convened by Professor Mike Stock.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2001;25(9):1272-4.
2001: Herve Boutin; Rosalind LeFeuvre; R Horai; M Asano; Y Iwakura; Nancy J Rothwell
Role of IL-1alpha and IL-1beta in ischemic brain damage.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(15):5528-34.
2001: Catherine B Lawrence; Nancy J Rothwell
Anorexic but not pyrogenic actions of interleukin-1 are modulated by central melanocortin-3/4 receptors in the rat.
Journal of neuroendocrinology 2001;13(6):490-5.
2001: T Cartmell; Giamal N Luheshi; Stephen J Hopkins; Nancy J Rothwell; Stephen Poole
Role of endogenous interleukin-1 receptor antagonist in regulating fever induced by localised inflammation in the rat.
The Journal of physiology 2001;531(Pt 1):171-80.
2001: Francisco Molina-Holgado; Richard K Grencis; Nancy J Rothwell
Actions of exogenous and endogenous IL-10 on glial responses to bacterial LPS/cytokines.
Glia 2001;33(2):97-106.
2000: Nancy J Rothwell; Giamal N Luheshi
Interleukin 1 in the brain: biology, pathology and therapeutic target.
Trends in neurosciences 2000;23(12):618-25.
2000: Aleksander Roberto Zampronio; Margaret E Hoadley; Giamal N Luheshi; Nancy J Rothwell; G E de Souza; Stephen J Hopkins
Interleukin (IL)-6 release and fever induced by a pre-formed pyrogenic factor (PFPF) derived from LPS-stimulated macrophages.
European cytokine network 2000;11(4):589-96.
2000: Francisco Molina-Holgado; S Toulmond; Nancy J Rothwell
Involvement of interleukin-1 in glial responses to lipopolysaccharide: endogenous versus exogenous interleukin-1 actions.
Journal of neuroimmunology 2000;111(1-2):1-9.
2000: MW Craighead; Herve Boutin; K M Middlehurst; Stuart M Allan; N Brooks; Ian Kimber; Nancy J Rothwell
Influence of corticotrophin releasing factor on neuronal cell death in vitro and in vivo.
Brain research 2000;881(2):139-43.
2000: Stuart M Allan; Nancy J Rothwell
Cortical death caused by striatal administration of AMPA and interleukin-1 is mediated by activation of cortical NMDA receptors.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2000;20(10):1409-13.
2000: T Cartmell; Stephen Poole; Andrew Turnbull; Nancy J Rothwell; Giamal N Luheshi
Circulating interleukin-6 mediates the febrile response to localised inflammation in rats.
The Journal of physiology 2000;526 Pt 3():653-61.
2000: Lisa C Parker; DA Rushforth; Nancy J Rothwell; Giamal N Luheshi
IL-1beta induced changes in hypothalamic IL-1R1 and IL-1R2 mRNA expression in the rat.
Brain research. Molecular brain research 2000;79(1-2):156-8.
2000: Nancy J Rothwell
Show them how it's really done.
Nature 2000;405(6787):621.
2000: Stuart M Allan; Lisa C Parker; B Collins; R Davies; Giamal N Luheshi; Nancy J Rothwell
Cortical cell death induced by IL-1 is mediated via actions in the hypothalamus of the rat.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5580-5.
2000: Rachel D Wheeler; A C Culhane; Matthew D Hall; Stuart Pickering-Brown; Nancy J Rothwell; Giamal N Luheshi
Detection of the interleukin 18 family in rat brain by RT-PCR.
Brain research. Molecular brain research 2000;77(2):290-3.
1999: Omar Touzani; Herve Boutin; Julien Chuquet; Nancy J Rothwell
Potential mechanisms of interleukin-1 involvement in cerebral ischaemia.
Journal of neuroimmunology 1999;100(1-2):203-15.
1999: Catherine B Lawrence; Andrew Turnbull; Nancy J Rothwell
Hypothalamic control of feeding.
Current opinion in neurobiology 1999;9(6):778-83.
1999: David Artis; Neil E Humphreys; Allison J Bancroft; Nancy J Rothwell; Christopher S Potten; Richard K Grencis
Tumor necrosis factor alpha is a critical component of interleukin 13-mediated protective T helper cell type 2 responses during helminth infection.
The Journal of experimental medicine 1999;190(7):953-62.
1999: Sarah A Loddick; Nancy J Rothwell
Mechanisms of tumor necrosis factor alpha action on neurodegeneration: interaction with insulin-like growth factor-1.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(17):9449-51.
1999: T Cartmell; Giamal N Luheshi; Nancy J Rothwell
Brain sites of action of endogenous interleukin-1 in the febrile response to localized inflammation in the rat.
The Journal of physiology 1999;518 ( Pt 2)():585-94.
1999: Giamal N Luheshi; J D Gardner; DA Rushforth; Andrew S I Loudon; Nancy J Rothwell
Leptin actions on food intake and body temperature are mediated by IL-1.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(12):7047-52.
1999: Robert Grundy; Nancy J Rothwell; Stuart M Allan
Dissociation between the effects of interleukin-1 on excitotoxic brain damage and body temperature in the rat.
Brain research 1999;830(1):32-7.
1999: V L Pearson; Nancy J Rothwell; S Toulmond
Excitotoxic brain damage in the rat induces interleukin-1beta protein in microglia and astrocytes: correlation with the progression of cell death.
Glia 1999;25(4):311-23.
1999: Christine Ann Davies; Sarah A Loddick; S Toulmond; RP Stroemer; J Hunt; Nancy J Rothwell
The progression and topographic distribution of interleukin-1beta expression after permanent middle cerebral artery occlusion in the rat.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1999;19(1):87-98.
1999: Nancy J Rothwell
Annual review prize lecture cytokines - killers in the brain?
The Journal of physiology 1999;514 ( Pt 1)():3-17.
1998: Christine Ann Davies; Sarah A Loddick; RP Stroemer; J Hunt; Nancy J Rothwell
An integrated analysis of the progression of cell responses induced by permanent focal middle cerebral artery occlusion in the rat.
Experimental neurology 1998;154(1):199-212.
1998: T Cartmell; Stephen Poole; Nancy J Rothwell; Giamal N Luheshi
Relationship between interleukin-1 and interleukin-1 receptor antagonist during the development of fever in the rat.
Annals of the New York Academy of Sciences 1998;856():252-5.
1998: H R Anforth; R M Bluthe; Adrian Bristow; S Hopkins; MJ Lenczowski; Giamal N Luheshi; Johan Lundkvist; B Michaud; Yogesh Mistry; Anne-Marie Van Dam; C Zhen; Robert Dantzer; Stephen Poole; Nancy J Rothwell; Fred J H Tilders; E E Wollman
Biological activity and brain actions of recombinant rat interleukin-1alpha and interleukin-1beta.
European cytokine network 1998;9(3):279-88.
1998: RP Stroemer; Nancy J Rothwell
Exacerbation of ischemic brain damage by localized striatal injection of interleukin-1beta in the rat.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1998;18(8):833-9.
1998: A C Culhane; Matthew D Hall; Nancy J Rothwell; Giamal N Luheshi
Cloning of rat brain interleukin-18 cDNA.
Molecular psychiatry 1998;3(4):362-6.
1998: E E Ochu; Nancy J Rothwell; CM Waters
Caspases mediate 6-hydroxydopamine-induced apoptosis but not necrosis in PC12 cells.
Journal of neurochemistry 1998;70(6):2637-40.
1998: Catherine B Lawrence; Stuart M Allan; Nancy J Rothwell
Interleukin-1beta and the interleukin-1 receptor antagonist act in the striatum to modify excitotoxic brain damage in the rat.
The European journal of neuroscience 1998;10(3):1188-95.
1998: Stuart M Allan; Catherine B Lawrence; Nancy J Rothwell
Interleukin-1 beta and interleukin-1 receptor antagonist do not affect glutamate release or calcium entry in rat striatal synaptosomes.
Molecular psychiatry 1998;3(2):178-82.
1998: SY Roe; E M McGowan; Nancy J Rothwell
Evidence for the involvement of corticotrophin-releasing hormone in the pathogenesis of traumatic brain injury.
The European journal of neuroscience 1998;10(2):553-9.
1998: Sarah A Loddick; Andrew Turnbull; Nancy J Rothwell
Cerebral interleukin-6 is neuroprotective during permanent focal cerebral ischemia in the rat.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1998;18(2):176-9.
1997: Nancy J Rothwell; Stuart Allan; S Toulmond
The role of interleukin 1 in acute neurodegeneration and stroke: pathophysiological and therapeutic implications.
The Journal of clinical investigation 1997;100(11):2648-52.
1997: Nancy J Rothwell
Sixteenth Gaddum Memorial Lecture December 1996. Neuroimmune interactions: the role of cytokines.
British journal of pharmacology 1997;121(5):841-7.
1997: RP Stroemer; Nancy J Rothwell
Cortical protection by localized striatal injection of IL-1ra following cerebral ischemia in the rat.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1997;17(6):597-604.
1997: SY Roe; Nancy J Rothwell
Whole body metabolic responses to brain trauma in the rat.
Journal of neurotrauma 1997;14(6):399-408.
1997: Sarah A Loddick; Ma-Li Wong; PB Bongiorno; P W Gold; Julio Licinio; Nancy J Rothwell
Endogenous interleukin-1 receptor antagonist is neuroprotective.
Biochemical and biophysical research communications 1997;234(1):211-5.
1997: SY Roe; A L Cooper; Ian morris; Nancy J Rothwell
Involvement of prostaglandins in cachexia induced by T-cell leukemia in the rat.
Metabolism: clinical and experimental 1997;46(4):359-65.
1997: SY Roe; A L Cooper; Ian morris; Stephen J Hopkins; Nancy J Rothwell
Involvement of cytokines in cachexia induced by T-cell leukaemia in the rat.
European cytokine network 1997;8(1):45-9.
1997: Nancy J Rothwell
Cytokines and acute neurodegeneration.
Molecular psychiatry 1997;2(2):120-1.
1997: Nancy J Rothwell; Sarah A Loddick; P Stroemer
Interleukins and cerebral ischaemia.
International review of neurobiology 1997;40():281-98.
1996: Sarah A Loddick; Nancy J Rothwell
Neuroprotective effects of human recombinant interleukin-1 receptor antagonist in focal cerebral ischaemia in the rat.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1996;16(5):932-40.
1996: A Stefferl; Stephen J Hopkins; Nancy J Rothwell; Giamal N Luheshi
The role of TNF-alpha in fever: opposing actions of human and murine TNF-alpha and interactions with IL-beta in the rat.
British journal of pharmacology 1996;118(8):1919-24.
1996: Sarah A Loddick; A MacKenzie; Nancy J Rothwell
An ICE inhibitor, z-VAD-DCB attenuates ischaemic brain damage in the rat.
Neuroreport 1996;7(9):1465-8.
1996: SY Roe; A L Cooper; Ian morris; Nancy J Rothwell
Mechanisms of cachexia induced by T-cell leukemia in the rat.
Metabolism: clinical and experimental 1996;45(5):645-51.
1996: A W Sudlow; F Carey; R Forder; Nancy J Rothwell
The role of lipocortin-1 in dexamethasone-induced suppression of PGE2 and TNF alpha release from human peripheral blood mononuclear cells.
British journal of pharmacology 1996;117(7):1449-56.
1996: Giamal N Luheshi; Nancy J Rothwell
Cytokines and fever.
International archives of allergy and immunology 1996;109(4):301-7.
1996: Nancy J Rothwell; Giamal N Luheshi; S Toulmond
Cytokines and their receptors in the central nervous system: physiology, pharmacology, and pathology.
Pharmacology & therapeutics 1996;69(2):85-95.
1996: Giamal N Luheshi; A J Miller; S Brouwer; Michael J Dascombe; Nancy J Rothwell; Stephen J Hopkins
Interleukin-1 receptor antagonist inhibits endotoxin fever and systemic interleukin-6 induction in the rat.
The American journal of physiology 1996;270(1 Pt 1):E91-5.
1996: A W Sudlow; F Carey; R Forder; Nancy J Rothwell
Lipocortin-1 inhibits CRH stimulation of plasma ACTH and IL-1 beta-stimulated hypothalamic CRH release in rats.
The American journal of physiology 1996;270(1 Pt 2):R54-60.
1995: Ma-Li Wong; Sarah A Loddick; PB Bongiorno; Philip W Gold; Nancy J Rothwell; Julio Licinio
Focal cerebral ischemia induces CRH mRNA in rat cerebral cortex and amygdala.
Neuroreport 1995;6(13):1785-8.
1995: Márcio M Coelho; Giamal N Luheshi; Stephen J Hopkins; Irene Rosemir Pelá; Nancy J Rothwell
Multiple mechanisms mediate antipyretic action of glucocorticoids.
The American journal of physiology 1995;269(3 Pt 2):R527-35.
1995: Nancy J Rothwell; P J Strijbos
Cytokines in neurodegeneration and repair.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 1995;13(3-4):179-85.
1995: P J Strijbos; Nancy J Rothwell
Interleukin-1 beta attenuates excitatory amino acid-induced neurodegeneration in vitro: involvement of nerve growth factor.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(5 Pt 1):3468-74.
1995: Nancy J Rothwell; S J Hopkins
Cytokines and the nervous system II: Actions and mechanisms of action.
Trends in neurosciences 1995;18(3):130-6.
1995: S Toulmond; Nancy J Rothwell
Interleukin-1 receptor antagonist inhibits neuronal damage caused by fluid percussion injury in the rat.
Brain research 1995;671(2):261-6.
1995: S J Hopkins; Nancy J Rothwell
Cytokines and the nervous system. I: Expression and recognition.
Trends in neurosciences 1995;18(2):83-8.
1994: A L Cooper; S Brouwer; Andrew Turnbull; Giamal N Luheshi; Stephen J Hopkins; Steven Kunkel; Nancy J Rothwell
Tumor necrosis factor-alpha and fever after peripheral inflammation in the rat.
The American journal of physiology 1994;267(6 Pt 2):R1431-6.
1994: P J Strijbos; J K Relton; Nancy J Rothwell
Corticotrophin-releasing factor antagonist inhibits neuronal damage induced by focal cerebral ischaemia or activation of NMDA receptors in the rat brain.
Brain research 1994;656(2):405-8.
1994: Nancy J Rothwell; Giamal N Luheshi
Pharmacology of interleukin-1 actions in the brain.
Advances in pharmacology (San Diego, Calif.) 1994;25():1-20.
1994: Andrew Turnbull; R C Dow; Stephen J Hopkins; A White; George Fink; Nancy J Rothwell
Mechanisms of activation of the pituitary-adrenal axis by tissue injury in the rat.
Psychoneuroendocrinology 1994;19(2):165-78.
1993: Nancy J Rothwell
Cytokines and thermogenesis.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1993;17 Suppl 3():S98-101; discussion 115.
1993: R H Derijk; P J Strijbos; Nico van Rooijen; Nancy J Rothwell; F Berkenbosch
Fever and thermogenesis in response to bacterial endotoxin involve macrophage-dependent mechanisms in rats.
The American journal of physiology 1993;265(5 Pt 2):R1179-83.
1993: Giamal N Luheshi; Stephen J Hopkins; R A Lefeuvre; Michael J Dascombe; P Ghiara; Nancy J Rothwell
Importance of brain IL-1 type II receptors in fever and thermogenesis in the rat.
The American journal of physiology 1993;265(4 Pt 1):E585-91.
1993: A L Cooper; Nancy J Rothwell
Inhibition of the thermogenic and pyrogenic responses to interleukin-1 beta in the rat by dietary N-3 fatty acid supplementation.
Prostaglandins, leukotrienes, and essential fatty acids 1993;49(2):615-26.
1993: P J Strijbos; Michael A Horan; F Carey; Nancy J Rothwell
Impaired febrile responses of aging mice are mediated by endogenous lipocortin-1 (annexin-1).
The American journal of physiology 1993;265(2 Pt 1):E289-97.
1993: Andrew Turnbull; Emrys Kirkman; Nancy J Rothwell; Roderick A Little
The neuropeptide CRF is involved in the modulation of the baroreflex during hindlimb ischaemia in the anaesthetized rat.
The Journal of physiology 1993;468():529-41.
1993: Márcio M Coelho; Irene Rosemir Pelá; Nancy J Rothwell
Dexamethasone inhibits the pyrogenic activity of prostaglandin F2 alpha, but not prostaglandin E2.
European journal of pharmacology 1993;238(2-3):391-4.
1993: N J Busbridge; Michael J Dascombe; Nancy J Rothwell
Chronic effects of interleukin-1 beta on fever, oxygen consumption and food intake in the rat.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1993;25(4):222-7.
1993: L Martineau; Roderick A Little; Nancy J Rothwell; M I Fisher
Clenbuterol, a beta 2-adrenergic agonist, reverses muscle wasting due to scald injury in the rat.
Burns : journal of the International Society for Burn Injuries 1993;19(1):26-34.
1993: Nancy J Rothwell; J K Relton
Involvement of cytokines in acute neurodegeneration in the CNS.
Neuroscience and biobehavioral reviews 1993;17(2):217-27.
1993: J K Relton; P J Strijbos; A L Cooper; Nancy J Rothwell
Dietary N-3 fatty acids inhibit ischaemic and excitotoxic brain damage in the rat.
Brain research bulletin 1993;32(3):223-6.
1993: Nancy J Rothwell; J K Relton
Involvement of interleukin-1 and lipocortin-1 in ischaemic brain damage.
Cerebrovascular and brain metabolism reviews 1993;5(3):178-98.
1992: Nancy J Rothwell; R A Le Feuvre
Thermogenesis, brown adipose tissue and dexfenfluramine in animal studies.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 1992;16 Suppl 3():S67-71.
1992: L Martineau; Michael A Horan; Nancy J Rothwell; Roderick A Little
Salbutamol, a beta 2-adrenoceptor agonist, increases skeletal muscle strength in young men.
Clinical science (London, England : 1979) 1992;83(5):615-21.
1992: L Martineau; Michael A Horan; Nancy J Rothwell; Roderick A Little
Muscling in on salbutamol.
Lancet 1992;340(8827):1094.
1992: P J Strijbos; A J Hardwick; J K Relton; F Carey; Nancy J Rothwell
Inhibition of central actions of cytokines on fever and thermogenesis by lipocortin-1 involves CRF.
The American journal of physiology 1992;263(4 Pt 1):E632-6.
1992: J K Relton; Nancy J Rothwell
Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat.
Brain research bulletin 1992;29(2):243-6.
1992: M D Black; F Carey; Alan R Crossman; J K Relton; Nancy J Rothwell
Lipocortin-1 inhibits NMDA receptor-mediated neuronal damage in the striatum of the rat.
Brain research 1992;585(1-2):135-40.
1992: J J Choo; Michael A Horan; Roderick A Little; Nancy J Rothwell
Anabolic effects of clenbuterol on skeletal muscle are mediated by beta 2-adrenoceptor activation.
The American journal of physiology 1992;263(1 Pt 1):E50-6.
1992: A L Cooper; Michael A Horan; Roderick A Little; Nancy J Rothwell
Metabolic and febrile responses to typhoid vaccine in humans: effect of beta-adrenergic blockade.
Journal of applied physiology (Bethesda, Md. : 1985) 1992;72(6):2322-8.
1992: Nancy J Rothwell
Eicosanoids, thermogenesis and thermoregulation.
Prostaglandins, leukotrienes, and essential fatty acids 1992;46(1):1-7.
1992: Nancy J Rothwell; R Flower
Lipocortin-1 exhibits novel actions, providing clinical opportunities.
Trends in pharmacological sciences 1992;13(2):45-6.
1991: A L Cooper; Nancy J Rothwell
Mechanisms of early and late hypermetabolism and fever after localized tissue injury in rats.
The American journal of physiology 1991;261(6 Pt 1):E698-705.
1991: Nancy J Rothwell
Functions and mechanisms of interleukin 1 in the brain.
Trends in pharmacological sciences 1991;12(11):430-6.
1991: Nancy J Rothwell; N J Busbridge; R A Lefeuvre; A J Hardwick; J Gauldie; Stephen J Hopkins
Interleukin-6 is a centrally acting endogenous pyrogen in the rat.
Canadian journal of physiology and pharmacology 1991;69(10):1465-9.
1991: R A Le Feuvre; L Aisenthal; Nancy J Rothwell
Involvement of corticotrophin releasing factor (CRF) in the thermogenic and anorexic actions of serotonin (5-HT) and related compounds.
Brain research 1991;555(2):245-50.
1991: J K Relton; P J Strijbos; C T O'Shaughnessy; F Carey; R A Forder; Fred J H Tilders; Nancy J Rothwell
Lipocortin-1 is an endogenous inhibitor of ischemic damage in the rat brain.
The Journal of experimental medicine 1991;174(2):305-10.
1991: P J Strijbos; Fred J H Tilders; F Carey; R Forder; Nancy J Rothwell
Localization of immunoreactive lipocortin-1 in the brain and pituitary gland of the rat. Effects of adrenalectomy, dexamethasone and colchicine treatment.
Brain research 1991;553(2):249-60.
1991: R A Le Feuvre; A J Woods; M J Stock; Nancy J Rothwell
Effects of central injection of glucose on thermogenesis in normal, VMH-lesioned and genetically obese rats.
Brain research 1991;547(1):110-4.
1991: Nancy J Rothwell; A Hardwick; R A LeFeuvre; S R Crosby; Anne White
Central actions of CRF on thermogenesis are mediated by pro-opiomelanocortin products.
Brain research 1991;541(1):89-92.
1991: Nancy J Rothwell
The endocrine significance of cytokines.
The Journal of endocrinology 1991;128(2):171-3.
1991: Nancy J Rothwell; Roderick A Little; J G Rose
Brown adipose tissue activity and oxygen consumption after scald injury in the rat.
Circulatory shock 1991;33(1):33-6.
1990: P Strijbos; Fred J H Tilders; F Carey; R Forder; Nancy J Rothwell
Localization of lipocortin-1 in normal rat brain.
Biochemical Society transactions 1990;18(6):1234-5.
1990: Nancy J Rothwell
Central activation of thermogenesis by prostaglandins: dependence on CRF.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1990;22(12):616-8.
1990: Nancy J Rothwell; A J Hardwick; I Lindley
Central actions of interleukin-8 in the rat are independent of prostaglandins.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1990;22(11):595-6.
1990: Nancy J Rothwell
Mechanisms of the pyrogenic actions of cytokines.
European cytokine network 1990;1(4):211-3.
1990: C T O'Shaughnessy; Nancy J Rothwell; J Shrewsbury-Gee
Sympathetically mediated hypermetabolic response to cerebral ischemia in the rat.
Canadian journal of physiology and pharmacology 1990;68(10):1334-7.
1990: J J Choo; Michael A Horan; Roderick A Little; Nancy J Rothwell; A Wareham
Anabolic beta-2-agonist clenbuterol fails to modify muscle atrophy due to femur fracture.
Circulatory shock 1990;32(2):165-71.
1990: N J Busbridge; J A Carnie; Michael J Dascombe; J A Johnston; Nancy J Rothwell
Adrenalectomy reverses the impaired pyrogenic responses to interleukin-beta in obese Zucker rats.
International journal of obesity 1990;14(9):809-14.
1990: J Arnold; J J Choo; Roderick A Little; Nancy J Rothwell
Dopamine beta-hydroxylase inhibition reveals a selective influence of endotoxin on catecholamine content of rat tissues.
Circulatory shock 1990;31(4):387-94.
1990: F Carey; R Forder; M D Edge; A R Greene; Michael A Horan; P J Strijbos; Nancy J Rothwell
Lipocortin 1 fragment modifies pyrogenic actions of cytokines in rats.
The American journal of physiology 1990;259(2 Pt 2):R266-9.
1990: J J Choo; Michael A Horan; Roderick A Little; Nancy J Rothwell
Effects of the beta 2-adrenoceptor agonist, clenbuterol, on muscle atrophy due to food deprivation in the rat.
Metabolism: clinical and experimental 1990;39(6):647-50.
1990: Nancy J Rothwell
Central effects of CRF on metabolism and energy balance.
Neuroscience and biobehavioral reviews 1990;14(3):263-71.
1989: H D McCarthy; C T O'Shaughnessy; Nancy J Rothwell
Endogenous mediators of cerebral ischaemia-induced hypermetabolism in the rat.
British journal of pharmacology 1989;98 Suppl():838P.
1989: A Bianchi; J Bruce; A L Cooper; C Childs; M Kohli; Ian morris; P Morris-Jones; Nancy J Rothwell
Increased brown adipose tissue activity in children with malignant disease.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1989;21(11):640-1.
1989: J J Choo; Michael A Horan; Roderick A Little; Nancy J Rothwell
Muscle wasting associated with endotoxemia in the rat: modification by the beta 2-adrenoceptor agonist clenbuterol.
Bioscience reports 1989;9(5):615-21.
1989: C T O'Shaughnessy; Nancy J Rothwell; J Shrewsbury-Gee
Effects of an analogue of thyrotrophin-releasing hormone, RX77368, on infarct size and cerebral blood flow in focal cerebral ischaemia in the rat.
Canadian journal of physiology and pharmacology 1989;67(10):1345-50.
1989: A L Cooper; Michael J Dascombe; Nancy J Rothwell; M J Vale
Effects of malaria on O2 consumption and brown adipose tissue activity in mice.
Journal of applied physiology (Bethesda, Md. : 1985) 1989;67(3):1020-3.
1989: Michael A Horan; R A Little; Nancy J Rothwell; P J Strijbos
Comparison of the effects of several endotoxin preparations on body temperature and metabolic rate in the rat.
Canadian journal of physiology and pharmacology 1989;67(9):1011-4.
1989: R A Le Feuvre; Nancy J Rothwell; A White
A comparison of the thermogenic effects of CRF, sauvagine and urotensin I in the rat.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1989;21(9):525-6.
1989: N J Busbridge; Michael J Dascombe; Fred J H Tilders; J W van Oers; E A Linton; Nancy J Rothwell
Central activation of thermogenesis and fever by interleukin-1 beta and interleukin-1 alpha involves different mechanisms.
Biochemical and biophysical research communications 1989;162(2):591-6.
1989: Nancy J Rothwell
Central control of brown adipose tissue.
The Proceedings of the Nutrition Society 1989;48(2):197-206.
1989: A J Hardwick; E A Linton; Nancy J Rothwell
Thermogenic effects of the antiglucocorticoid RU-486 in the rat: involvement of corticotropin-releasing factor and sympathetic activation of brown adipose tissue.
Endocrinology 1989;124(4):1684-8.
1989: Michael J Dascombe; A Hardwick; R A Lefeuvre; Nancy J Rothwell
Impaired effects of interleukin-1 beta on fever and thermogenesis in genetically obese rats.
International journal of obesity 1989;13(3):367-73.
1989: Michael J Dascombe; Nancy J Rothwell; B O Sagay; M J Stock
Pyrogenic and thermogenic effects of interleukin 1 beta in the rat.
The American journal of physiology 1989;256(1 Pt 1):E7-11.
1989: Nancy J Rothwell
CRF is involved in the pyrogenic and thermogenic effects of interleukin 1 beta in the rat.
The American journal of physiology 1989;256(1 Pt 1):E111-5.
1989: A L Cooper; R B Fitzgeorge; A Baskerville; Roderick A Little; Nancy J Rothwell
Bacterial infection (Legionella pneumophila) stimulates fever, metabolic rate and brown adipose tissue activity in the guinea pig.
Life sciences 1989;45(9):843-7.
1988: Nancy J Rothwell; M J Stock
Brown adipose tissue: does it play a role in the development of obesity?
Diabetes/metabolism reviews 1988;4(6):595-601.
1988: Nancy J Rothwell
Central effects of TNF alpha on thermogenesis and fever in the rat.
Bioscience reports 1988;8(4):345-52.
1988: E C Griffiths; Nancy J Rothwell; M J Stock
Thermogenic effects of thyrotrophin-releasing hormone and its analogues in the rat.
Experientia 1988;44(1):40-2.
1988: Nancy J Rothwell; M J Stock
Insulin and thermogenesis.
International journal of obesity 1988;12(2):93-102.
1988: Michael A Horan; Roderick A Little; Nancy J Rothwell; M J Stock
Changes in body composition, brown adipose tissue activity and thermogenic capacity in BN/BiRij rats undergoing senescence.
Experimental gerontology 1988;23(6):455-61.