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Robert Rottapel

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Grace Chen; Ioannis Dimitriou; Noah Fine; Paul Kubes; Karl S Lang; Philipp A Lang; Laura Milne; Pamela S Ohashi; Robert Rottapel
The 3BP2 adapter protein is required for chemoattractant-mediated neutrophil activation.
Christopher B Marshall; Mohammad T Mazhab-Jafari; David Meiri; Robert Rottapel; Matthew J Smith; Vuk Stambolic; Geneviève M C Gasmi-Seabrook; Mitsuhiko Ikura
Probing the GTPase cycle with real-time NMR: GAP and GEF activities in cell extracts.
David Meiri; Fernando Suarez; Chuanjin Wu; Chris Bakal; Marc Balan; Noah Fine; Melissa A Greeve; Mitsuhiko Ikura; Bryan Kim; Jose Larose; Christopher B Marshall; Robert Rottapel
Mechanistic insight into the microtubule and actin cytoskeleton coupling through dynein-dependent RhoGEF inhibition.

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All Publications

2012: Grace Chen; Ioannis Dimitriou; Noah Fine; Paul Kubes; Karl S Lang; Philipp A Lang; Laura Milne; Pamela S Ohashi; Robert Rottapel
The 3BP2 adapter protein is required for chemoattractant-mediated neutrophil activation.
Journal of immunology (Baltimore, Md. : 1950) 2012;189(5):2138-50.
2012: Christopher B Marshall; Mohammad T Mazhab-Jafari; David Meiri; Robert Rottapel; Matthew J Smith; Vuk Stambolic; Geneviève M C Gasmi-Seabrook; Mitsuhiko Ikura
Probing the GTPase cycle with real-time NMR: GAP and GEF activities in cell extracts.
Methods (San Diego, Calif.) 2012;57(4):473-85.
2012: David Meiri; Fernando Suarez; Chuanjin Wu; Chris Bakal; Marc Balan; Noah Fine; Melissa A Greeve; Mitsuhiko Ikura; Bryan Kim; Jose Larose; Christopher B Marshall; Robert Rottapel
Mechanistic insight into the microtubule and actin cytoskeleton coupling through dynein-dependent RhoGEF inhibition.
Molecular cell 2012;45(5):642-55.
2012: Richard Marcotte; Mauricio Medrano; Patricia Mero; Christine Misquitta; Glauber C Brito; Kevin R Brown; Alla Buzina; Alessandro Datti; Bohdana Fedyshyn; Yaroslav Fedyshyn; Maliha Haider; Konstantina Karamboulas; Dahlia Kasimer; Troy Ketela; Judice L Y Koh; Paul M Krzyzanowski; Marianna Luhova; Benjamin G Neel; Josee Normand; Robert Rottapel; Azin Sayad; Fabrice Sircoulomb; Fernando Suarez; Dewald van Dyk; Franco J Vizeacoumar; Frederick S Vizeacoumar; Jeffrey L Wrana; Jason Moffat
Essential gene profiles in breast, pancreatic, and ovarian cancer cells.
Cancer discovery 2012;2(2):172-89.
2012: Ivan Borozan; Philip E Branton; Paola Blanchette; Paul M Krzyzanowski; Philippe Laflamme; Robert Rottapel; Fabrice Sircoulomb; Stuart N Watt; Shane Wilson; Vincent Ferretti
CaPSID: a bioinformatics platform for computational pathogen sequence identification in human genomes and transcriptomes.
BMC bioinformatics 2012;13():206.
2012: Fiona M Guerra; Christopher J Paige; Steven A Corfe; Jennifer L Gommerman; Robert Rottapel
Homeodomain-interacting protein kinase (HIPK)-1 is required for splenic B cell homeostasis and optimal T-independent type 2 humoral response.
PloS one 2012;7(4):e35533.
2011: Steven A Corfe; Robert Rottapel; Christopher J Paige
Modulation of IL-7 thresholds by SOCS proteins in developing B lineage cells.
Journal of immunology (Baltimore, Md. : 1950) 2011;187(7):3499-510.
2010: Amel GuezGuez; Virginie Prod'homme; Xavier Mouska; Alice Baudot; Claudine Blin-Wakkach; Robert Rottapel; Marcel Deckert
3BP2 adapter protein is required for receptor activator of NFκB ligand (RANKL)-induced osteoclast differentiation of RAW264.7 cells.
The Journal of biological chemistry 2010;285(27):20952-63.
2010: Sheela Ramanathan; Stephanie Dubois; Julien Gagnon; Chantal Leblanc; Sanjeev Mariathasan; Gerardo Ferbeyre; Robert Rottapel; Pamela S Ohashi; Subburaj Ilangumaran
Regulation of cytokine-driven functional differentiation of CD8 T cells by suppressor of cytokine signaling 1 controls autoimmunity and preserves their proliferative capacity toward foreign antigens.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(1):357-66.
2010: Pooja Jain; Caroline Coisne; Gaby Enzmann; Robert Rottapel; Britta Engelhardt
Alpha4beta1 integrin mediates the recruitment of immature dendritic cells across the blood-brain barrier during experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(12):7196-206.
2010: Paul A Spagnuolo; Jiayi Hu; Rose Hurren; Xiaoming Wang; Marcela Gronda; Mahadeo A Sukhai; Ashley Di Meo; Jonathan Boss; Iman Ashali; Reza Beheshti Zavareh; Noah Fine; Craig D Simpson; Sumaiya Sharmeen; Robert Rottapel; Aaron D Schimmer
The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma.
Blood 2010;115(23):4824-33.
2010: Laia Gómez-Baldó; Stephan Schmidt; Christopher A Maxwell; Núria Bonifaci; Toni Gabaldón; Pierre-Olivier Vidalain; William Senapedis; Anja Kletke; Mechthild Rosing; Angelika Barnekow; Robert Rottapel; Gabriel Capellá; Marc Vidal; Aristotelis Astrinidis; Roland P Piekorz; Miguel Angel Pujana
TACC3-TSC2 maintains nuclear envelope structure and controls cell division.
Cell cycle (Georgetown, Tex.) 2010;9(6):1143-55.
2010: Mohammad T Mazhab-Jafari; Christopher B Marshall; Matthew Smith; Geneviève M C Gasmi-Seabrook; Vuk Stambolic; Robert Rottapel; Benjamin G Neel; Mitsuhiko Ikura
Real-time NMR study of three small GTPases reveals that fluorescent 2'(3')-O-(N-methylanthraniloyl)-tagged nucleotides alter hydrolysis and exchange kinetics.
The Journal of biological chemistry 2010;285(8):5132-6.
2009: David Meiri; Melissa A Greeve; Andrea Brunet; Dina Finan; Clark D Wells; Jose LaRose; Robert Rottapel
Modulation of Rho guanine exchange factor Lfc activity by protein kinase A-mediated phosphorylation.
Molecular and cellular biology 2009;29(21):5963-73.
2009: Andrée Gauthier-Fisher; Dan C Lin; Melissa Greeve; David R Kaplan; Robert Rottapel; Freda D Miller
Lfc and Tctex-1 regulate the genesis of neurons from cortical precursor cells.
Nature neuroscience 2009;12(6):735-44.
2008: Ioannis D Dimitriou; Liliana Clemenza; Andrew J Scotter; Grace Chen; Fiona M Guerra; Robert Rottapel
Putting out the fire: coordinated suppression of the innate and adaptive immune systems by SOCS1 and SOCS3 proteins.
Immunological reviews 2008;224():265-83.
2008: Fabien Garçon; Daniel Patton; Juliet L Emery; Emilio Hirsch; Robert Rottapel; Takehiko Sasaki; Klaus Okkenhaug
CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer.
Blood 2008;111(3):1464-71.
2008: Mats Dehlin; Maria Bokarewa; Robert Rottapel; Simon J Foster; Mattias Magnusson; Leif Dahlberg; Andrej Tarkowski
Intra-articular fms-like tyrosine kinase 3 ligand expression is a driving force in induction and progression of arthritis.
PloS one 2008;3(11):e3633.
2007: Grace Chen; Ioannis D Dimitriou; Jose La Rose; Subburaj Ilangumaran; Wen-Chen Yeh; Gina Doody; Martin Turner; Jennifer L Gommerman; Robert Rottapel
The 3BP2 adapter protein is required for optimal B-cell activation and thymus-independent type 2 humoral response.
Molecular and cellular biology 2007;27(8):3109-22.
2007: Queenie Lai Kwan Lam; Cherry Kam Chun Lo; Bo-Jian Zheng; King-Hung Ko; Dennis G Osmond; Gillian E Wu; Robert Rottapel; Liwei Lu
Impaired V(D)J recombination and increased apoptosis among B cell precursors in the bone marrow of c-Abl-deficient mice.
International immunology 2007;19(3):267-76.
2006: Sheela Ramanathan; Julien Gagnon; Chantal Leblanc; Robert Rottapel; Subburaj Ilangumaran
Suppressor of cytokine signaling 1 stringently regulates distinct functions of IL-7 and IL-15 in vivo during T lymphocyte development and homeostasis.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(7):4029-41.
2006: Marcel Deckert; Robert Rottapel
The adapter 3BP2: how it plugs into leukocyte signaling.
Advances in experimental medicine and biology 2006;584():107-14.
2005: Katsuya Tsuchihara; Valentina Lapin; Christopher Bakal; Hitoshi Okada; Lauren Brown; Masami Hirota-Tsuchihara; Kathrin Zaugg; Alexandra Ho; Annick Itie-Youten; Marees Harris-Brandts; Robert Rottapel; Christopher D Richardson; Samuel Benchimol; Tak Wah Mak
Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner.
Cancer research 2005;65(15):6685-91.
2005: Christopher Bakal; Dina Finan; José LaRose; Clark D Wells; Gerald Gish; Sarang Kulkarni; Paulo DeSepulveda; Andrew Wilde; Robert Rottapel
The Rho GTP exchange factor Lfc promotes spindle assembly in early mitosis.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(27):9529-34.
2005: Linda X Wu; Jose La Rose; Liane Chen; Chris Neale; Tak Mak; Klaus Okkenhaug; Ronald Wange; Robert Rottapel
CD28 regulates the translation of Bcl-xL via the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway.
Journal of immunology (Baltimore, Md. : 1950) 2005;174(1):180-94.
2004: Subburaj Ilangumaran; Sheela Ramanathan; Robert Rottapel
Regulation of the immune system by SOCS family adaptor proteins.
Seminars in immunology 2004;16(6):351-65.
2004: Hiromitsu Hara; Christopher Bakal; Teiji Wada; Denis Bouchard; Robert Rottapel; Takashi Saito; Josef M Penninger
The molecular adapter Carma1 controls entry of IkappaB kinase into the central immune synapse.
The Journal of experimental medicine 2004;200(9):1167-77.
2004: Oliver Utting; Bradley J Sedgmen; Tania H Watts; Xiaoshu Shi; Robert Rottapel; Angelo Iulianella; David Lohnes; André Veillette
Immune functions in mice lacking Clnk, an SLP-76-related adaptor expressed in a subset of immune cells.
Molecular and cellular biology 2004;24(13):6067-75.
2004: Parham Minoo; Maryam Mohsen Zadeh; Robert Rottapel; Jean-Jacques Lebrun; Suhad Ali
A novel SHP-1/Grb2-dependent mechanism of negative regulation of cytokine-receptor signaling: contribution of SHP-1 C-terminal tyrosines in cytokine signaling.
Blood 2004;103(4):1398-407.
2004: Hitoshi Okada; Christopher Bakal; Arda Shahinian; Andrew Elia; Andrew Wakeham; Woong-Kyung Suh; Gordon S Duncan; Maria Ciofani; Robert Rottapel; Juan Carlos Zúñiga-Pflücker; Tak W Mak
Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death.
The Journal of experimental medicine 2004;199(3):399-410.
2003: Akihide Ryo; Futoshi Suizu; Yasuhiro Yoshida; Kilian Perrem; Yih-Cherng Liou; Gerburg Wulf; Robert Rottapel; Shoji Yamaoka; Kun Ping Lu
Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA.
Molecular cell 2003;12(6):1413-26.
2003: Subburaj Ilangumaran; Sheela Ramanathan; Terri Ning; Jose La Rose; Brandon Reinhart; Philippe Poussier; Robert Rottapel
Suppressor of cytokine signaling 1 attenuates IL-15 receptor signaling in CD8+ thymocytes.
Blood 2003;102(12):4115-22.
2003: Subburaj Ilangumaran; Dina Finan; Jason Raine; Robert Rottapel
Suppressor of cytokine signaling 1 regulates an endogenous inhibitor of a mast cell protease.
The Journal of biological chemistry 2003;278(43):41871-80.
2003: Subburaj Ilangumaran; Sheela Ramanathan; Jose La Rose; Philippe Poussier; Robert Rottapel
Suppressor of cytokine signaling 1 regulates IL-15 receptor signaling in CD8+CD44high memory T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(5):2435-45.
2003: Nathalie Casteran; Paulo de Sepulveda; Nathalie Beslu; Mustapha Aoubala; Sébastien Letard; Eric Lecocq; Robert Rottapel; Patrice Dubreuil
Signal transduction by several KIT juxtamembrane domain mutations.
Oncogene 2003;22(30):4710-22.
2003: Subburaj Ilangumaran; Dina Finan; Robert Rottapel
Flow cytometric analysis of cytokine receptor signal transduction.
Journal of immunological methods 2003;278(1-2):221-34.
2003: Hiromitsu Hara; Teiji Wada; Christopher Bakal; Ivona Kozieradzki; Shinobu Suzuki; Nobutaka Suzuki; Mai Nghiem; Emily K Griffiths; Connie M Krawczyk; Birgit Bauer; Fulvio D'Acquisto; Sankar Ghosh; Wen-Chen Yeh; Gottfried Baier; Robert Rottapel; Josef M Penninger
The MAGUK family protein CARD11 is essential for lymphocyte activation.
Immunity 2003;18(6):763-75.
2003: Perry M Chan; Subburaj Ilangumaran; Jose La Rose; Avijit Chakrabartty; Robert Rottapel
Autoinhibition of the kit receptor tyrosine kinase by the cytosolic juxtamembrane region.
Molecular and cellular biology 2003;23(9):3067-78.
2003: Subburaj Ilangumaran; Robert Rottapel
Regulation of cytokine receptor signaling by SOCS1.
Immunological reviews 2003;192():196-211.
2002: Subburaj Ilangumaran; Dina Finan; Jose La Rose; Jason Raine; Anna Silverstein; Paulo de Sepulveda; Robert Rottapel
A positive regulatory role for suppressor of cytokine signaling 1 in IFN-gamma-induced MHC class II expression in fibroblasts.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(9):5010-20.
2002: Rizwan Haq; James D Brenton; Mark Takahashi; Dina Finan; Ariel Finkielsztein; Sambasivarao Damaraju; Robert Rottapel; Brent Zanke
Constitutive p38HOG mitogen-activated protein kinase activation induces permanent cell cycle arrest and senescence.
Cancer research 2002;62(17):5076-82.
2002: Russell G Jones; Alisha R Elford; Michael J Parsons; Linda Wu; Connie M Krawczyk; Wen-Chen Yeh; Raza Hakem; Robert Rottapel; James R Woodgett; Pamela S Ohashi
CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly.
The Journal of experimental medicine 2002;196(3):335-48.
2002: Robert Rottapel; Subburaj Ilangumaran; Chris Neale; Jose La Rose; Jenny M-Y Ho; Melody H-H Nguyen; Dwayne Barber; Patrice Dubreuil; Paulo de Sepulveda
The tumor suppressor activity of SOCS-1.
Oncogene 2002;21(28):4351-62.
2001: Roland P Bourette; Paulo de Sepulveda; Sylvie Arnaud; Patrice Dubreuil; Robert Rottapel; Guy Mouchiroud
Suppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates its proliferation signal.
The Journal of biological chemistry 2001;276(25):22133-9.
2001: Sebastién Trop; Paulo de Sepulveda; Juan Carlos Zúñiga-Pflücker; Robert Rottapel
Overexpression of suppressor of cytokine signaling-1 impairs pre-T-cell receptor-induced proliferation but not differentiation of immature thymocytes.
Blood 2001;97(8):2269-77.
2001: Klaus Okkenhaug; Linda Wu; K M Garza; Jose La Rose; W Khoo; Bernhard Odermatt; Tak W Mak; Pamela S Ohashi; Robert Rottapel
A point mutation in CD28 distinguishes proliferative signals from survival signals.
Nature immunology 2001;2(4):325-32.
2000: Paulo de Sepulveda; Subburaj Ilangumaran; Robert Rottapel
Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation.
The Journal of biological chemistry 2000;275(19):14005-8.
1999: Bernadine L Leung; Loralee Haughn; André Veillette; Robert G Hawley; Robert Rottapel; Michael Julius
TCR alpha beta-independent CD28 signaling and costimulation require non-CD4-associated Lck.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(3):1334-41.
1999: Paulo de Sepulveda; Klaus Okkenhaug; J L Rose; R G Hawley; Patrice Dubreuil; Robert Rottapel
Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation.
The EMBO journal 1999;18(4):904-15.
1998: Klaus Okkenhaug; Robert Rottapel
Grb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interaction.
The Journal of biological chemistry 1998;273(33):21194-202.
1997: Jennifer L Gommerman; Robert Rottapel; Stuart A Berger
Phosphatidylinositol 3-kinase and Ca2+ influx dependence for ligand-stimulated internalization of the c-Kit receptor.
The Journal of biological chemistry 1997;272(48):30519-25.
1997: LE Marengère; Klaus Okkenhaug; A Clavreul; Dominique Couez; S Gibson; Gordon B Mills; Tak W Mak; Robert Rottapel
The SH3 domain of Itk/Emt binds to proline-rich sequences in the cytoplasmic domain of the T cell costimulatory receptor CD28.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(7):3220-9.