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Peter Roughley

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Wuertz Karin; Godburn Karolyn; MacLean Jeffrey J; Barbir Ana; Donnelly Justin Stinnett; Roughley Peter J; Alini Mauro; Iatridis James C
In vivo remodeling of intervertebral discs in response to short- and long-term dynamic compression.
Durigova M; Soucy P; Fushimi K; Nagase H; Mort J S; Roughley P J
Characterization of an ADAMTS-5-mediated cleavage site in aggrecan in OSM-stimulated bovine cartilage.
Kafienah Wael; Cheung Frank L; Sims Trevor; Martin Ivan; Miot Sylvie; Von Ruhland Chris; Roughley Peter J; Hollander Anthony P
Lumican inhibits collagen deposition in tissue engineered cartilage.

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All Publications

2009: Wuertz Karin; Godburn Karolyn; MacLean Jeffrey J; Barbir Ana; Donnelly Justin Stinnett; Roughley Peter J; Alini Mauro; Iatridis James C
In vivo remodeling of intervertebral discs in response to short- and long-term dynamic compression.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2009;27(9):1235-42.
2008: Durigova M; Soucy P; Fushimi K; Nagase H; Mort J S; Roughley P J
Characterization of an ADAMTS-5-mediated cleavage site in aggrecan in OSM-stimulated bovine cartilage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2008;16(10):1245-52.
2008: Kafienah Wael; Cheung Frank L; Sims Trevor; Martin Ivan; Miot Sylvie; Von Ruhland Chris; Roughley Peter J; Hollander Anthony P
Lumican inhibits collagen deposition in tissue engineered cartilage.
Matrix biology : journal of the International Society for Matrix Biology 2008;27(6):526-34.
2008: MacLean Jeffrey J; Roughley Peter J; Monsey Robert D; Alini Mauro; Iatridis James C
In vivo intervertebral disc remodeling: kinetics of mRNA expression in response to a single loading event.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2008;26(5):579-88.
2008: Martel-Pelletier Johanne; Boileau Christelle; Pelletier Jean-Pierre; Roughley Peter J
Cartilage in normal and osteoarthritis conditions.
Best practice & research. Clinical rheumatology 2008;22(2):351-84.
2008: D'Onofrio Marie-France; Brézillon Stéphane; Baranek Thomas; Perreau Corinne; Roughley Peter J; Maquart François-Xavier; Wegrowski Yanusz
Identification of beta1 integrin as mediator of melanoma cell adhesion to lumican.
Biochemical and biophysical research communications 2008;365(2):266-72.
2008: Durigova M; Roughley P J; Mort J S
Mechanism of proteoglycan aggregate degradation in cartilage stimulated with oncostatin M.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2008;16(1):98-104.
2008: Melrose James; Fuller Emily S; Roughley Peter J; Smith Margaret M; Kerr Briedgeen; Hughes Clare E; Caterson Bruce; Little Christopher B
Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues.
Arthritis research & therapy 2008;10(4):R79.
2007: Melrose James; Smith Susan M; Fuller Emily S; Young Allan A; Roughley Peter J; Dart Andrew; Little Christopher B
Biglycan and fibromodulin fragmentation correlates with temporal and spatial annular remodelling in experimentally injured ovine intervertebral discs.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2007;16(12):2193-205.
2007: Grover J; Lee E R; Mounkes L C; Stewart C L; Roughley P J
The consequence of PRELP overexpression on skin.
Matrix biology : journal of the International Society for Matrix Biology 2007;26(2):140-3.
2007: Marini Joan C; Forlino Antonella; Cabral Wayne A; Barnes Aileen M; San Antonio James D; Milgrom Sarah; Hyland James C; Körkkö Jarmo; Prockop Darwin J; De Paepe Anne; Coucke Paul; Symoens Sofie; Glorieux Francis H; Roughley Peter J; Lund Alan M; Kuurila-Svahn Kaija; Hartikka Heini; Cohn Daniel H; Krakow Deborah; Mottes Monica; Schwarze Ulrike; Chen Diana; Yang Kathleen; Kuslich Christine; Troendle James; Dalgleish Raymond; Byers Peter H
Consortium for osteogenesis imperfecta mutations in the helical domain of type I collagen: regions rich in lethal mutations align with collagen binding sites for integrins and proteoglycans.
Human mutation 2007;28(3):209-21.
2007: Mort John S; Roughley Peter J
Measurement of glycosaminoglycan release from cartilage explants.
Methods in molecular medicine 2007;135():201-9.
2006: Melrose James; Roughley Peter; Knox Sarah; Smith Susan; Lord Megan; Whitelock John
The structure, location, and function of perlecan, a prominent pericellular proteoglycan of fetal, postnatal, and mature hyaline cartilages.
The Journal of biological chemistry 2006;281(48):36905-14.
2006: Melching L I; Fisher W D; Lee E R; Mort J S; Roughley P J
The cleavage of biglycan by aggrecanases.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2006;14(11):1147-54.
2006: Geng Yeqing; McQuillan David; Roughley Peter J
SLRP interaction can protect collagen fibrils from cleavage by collagenases.
Matrix biology : journal of the International Society for Matrix Biology 2006;25(8):484-91.
2006: Sivan Sarit Sara; Tsitron Eve; Wachtel Ellen; Roughley Peter; Sakkee Nico; van der Ham Frits; Degroot Jeroen; Maroudas Alice
Age-related accumulation of pentosidine in aggrecan and collagen from normal and degenerate human intervertebral discs.
The Biochemical journal 2006;399(1):29-35.
2006: Séguin Cheryle A; Bojarski Marla; Pilliar Robert M; Roughley Peter J; Kandel Rita A
Differential regulation of matrix degrading enzymes in a TNFalpha-induced model of nucleus pulposus tissue degeneration.
Matrix biology : journal of the International Society for Matrix Biology 2006;25(7):409-18.
2006: Yasuda Tadashi; Tchetina Elena; Ohsawa Kunitaka; Roughley Peter J; Wu William; Mousa Aisha; Ionescu Mirela; Pidoux Isabelle; Poole A Robin
Peptides of type II collagen can induce the cleavage of type II collagen and aggrecan in articular cartilage.
Matrix biology : journal of the International Society for Matrix Biology 2006;25(7):419-29.
2006: Adams Michael A; Roughley Peter J
What is intervertebral disc degeneration, and what causes it?
Spine 2006;31(18):2151-61.
2006: Mwale Fackson; Stachura Dorothy; Roughley Peter; Antoniou John
Limitations of using aggrecan and type X collagen as markers of chondrogenesis in mesenchymal stem cell differentiation.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2006;24(8):1791-8.
2006: Roughley Peter J; Melching Lee I; Heathfield Terrence F; Pearce Richard H; Mort John S
The structure and degradation of aggrecan in human intervertebral disc.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2006;15 Suppl 3():S326-32.
2006: Rodriguez E; Roughley P
Link protein can retard the degradation of hyaluronan in proteoglycan aggregates.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2006;14(8):823-9.
2006: Rodriguez Elida; Roland Samantha Kim; Plaas Anna; Roughley Peter J
The glycosaminoglycan attachment regions of human aggrecan.
The Journal of biological chemistry 2006;281(27):18444-50.
2006: Sivan Sarit S; Tsitron Eve; Wachtel Ellen; Roughley Peter J; Sakkee Nico; van der Ham Frits; DeGroot Jeroen; Roberts Sally; Maroudas Alice
Aggrecan turnover in human intervertebral disc as determined by the racemization of aspartic acid.
The Journal of biological chemistry 2006;281(19):13009-14.
2006: Iatridis James C; MacLean Jeffrey J; Roughley Peter J; Alini Mauro
Effects of mechanical loading on intervertebral disc metabolism in vivo.
The Journal of bone and joint surgery. American volume 2006;88 Suppl 2():41-6.
2006: Grover Judy; Roughley Peter J
Generation of a transgenic mouse in which Cre recombinase is expressed under control of the type II collagen promoter and doxycycline administration.
Matrix biology : journal of the International Society for Matrix Biology 2006;25(3):158-65.
2006: Roughley Peter; Hoemann Caroline; DesRosiers Eric; Mwale Fackson; Antoniou John; Alini Mauro
The potential of chitosan-based gels containing intervertebral disc cells for nucleus pulposus supplementation.
Biomaterials 2006;27(3):388-96.
2006: Roughley P J
The structure and function of cartilage proteoglycans.
European cells & materials 2006;12():92-101.
2006: Monfort Jordi; Tardif Ginette; Reboul Pascal; Mineau François; Roughley Peter; Pelletier Jean-Pierre; Martel-Pelletier Johanne
Degradation of small leucine-rich repeat proteoglycans by matrix metalloprotease-13: identification of a new biglycan cleavage site.
Arthritis research & therapy 2006;8(1):R26.
2006: Roughley P; Martens D; Rantakokko J; Alini M; Mwale F; Antoniou J
The involvement of aggrecan polymorphism in degeneration of human intervertebral disc and articular cartilage.
European cells & materials 2006;11():1-7; discussion 7.
2005: Séguin Cheryle A; Pilliar Robert M; Roughley Peter J; Kandel Rita A
Tumor necrosis factor-alpha modulates matrix production and catabolism in nucleus pulposus tissue.
Spine 2005;30(17):1940-8.
2005: de Medeiros Matsushita Marcus; da Silva Luiz Fernando Ferraz; dos Santos Mario Adriano; Fernezlian Sandra; Schrumpf Jasmijn A; Roughley Peter; Hiemstra Pieter S; Saldiva Paulo Hilário Nascimento; Mauad Thais; Dolhnikoff Marisa
Airway proteoglycans are differentially altered in fatal asthma.
The Journal of pathology 2005;207(1):102-10.
2005: Talusan Paul; Bedri Shahinaz; Yang Suping; Kattapuram Taj; Silva Nilsa; Roughley Peter J; Stone James R
Analysis of intimal proteoglycans in atherosclerosis-prone and atherosclerosis-resistant human arteries by mass spectrometry.
Molecular & cellular proteomics : MCP 2005;4(9):1350-7.
2005: Roughley Peter J; Melching Lee I; Mort John S
Insect cell conditioned medium contains an endoglycosidase able to liberate chondroitin sulfate chains from aggrecan.
Matrix biology : journal of the International Society for Matrix Biology 2005;24(5):371-5.
2005: Yu Vionnie W C; Ambartsoumian Gourgen; Verlinden Lieve; Moir Janet M; Prud'homme Josée; Gauthier Claude; Roughley Peter J; St-Arnaud René
FIAT represses ATF4-mediated transcription to regulate bone mass in transgenic mice.
The Journal of cell biology 2005;169(4):591-601.
2005: Mwale Fackson; Iordanova Mihaela; Demers Caroline N; Steffen Thomas; Roughley Peter; Antoniou John
Biological evaluation of chitosan salts cross-linked to genipin as a cell scaffold for disk tissue engineering.
Tissue engineering 2005;11(1-2):130-40.
2005: Hayashi Yasuhito; Liu Chia-Yang; Jester James J; Hayashi Miyuki; Wang I-Jong; Funderburgh James L; Saika Shizuya; Roughley Peter J; Kao Candace Whei-Cheng; Kao Winston Whei-Yang
Excess biglycan causes eyelid malformation by perturbing muscle development and TGF-alpha signaling.
Developmental biology 2005;277(1):222-34.
2005: Fust Anita; LeBellego Frederique; Iozzo Renato V; Roughley Peter J; Ludwig Mara S
Alterations in lung mechanics in decorin-deficient mice.
American journal of physiology. Lung cellular and molecular physiology 2005;288(1):L159-66.
2005: Young Allan A; Smith Margaret M; Smith Susan M; Cake Martin A; Ghosh Peter; Read Richard A; Melrose James; Sonnabend David H; Roughley Peter J; Little Christopher B
Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis.
Arthritis research & therapy 2005;7(4):R852-61.
2004: Roughley Peter J
Biology of intervertebral disc aging and degeneration: involvement of the extracellular matrix.
Spine 2004;29(23):2691-9.
2004: An Howard S; Anderson Paul A; Haughton Victor M; Iatridis James C; Kang James D; Lotz Jeffrey C; Natarajan Raghu N; Oegema Theodore R; Roughley Peter; Setton Lori A; Urban Jill P; Videman Tapio; Andersson Gunnar B J; Weinstein James N
Introduction: disc degeneration: summary.
Spine 2004;29(23):2677-8.
2004: Shi Shuiliang; Grothe Suzanne; Zhang Yiping; O'Connor-McCourt Maureen D; Poole A Robin; Roughley Peter J; Mort John S
Link protein has greater affinity for versican than aggrecan.
The Journal of biological chemistry 2004;279(13):12060-6.
2004: Botella Luisa M; Sanz-Rodriguez Francisco; Sanchez-Elsner Tilman; Langa Carmen; Ramirez Jose R; Vary Calvin; Roughley Peter J; Bernabeu Carmelo
Lumican is down-regulated in cells expressing endoglin. Evidence for an inverse correlationship between Endoglin and Lumican expression.
Matrix biology : journal of the International Society for Matrix Biology 2004;22(7):561-72.
2004: Mwale F; Roughley P; Antoniou J
Distinction between the extracellular matrix of the nucleus pulposus and hyaline cartilage: a requisite for tissue engineering of intervertebral disc.
European cells & materials 2004;8():58-63; discussion 63-4.
2004: Mort John S; Roughley Peter J
Production of antibodies against degradative neoepitopes in aggrecan.
Methods in molecular medicine 2004;100():237-50.
2003: Roughley Peter J; Barnett James; Zuo Fengrong; Mort John S
Variations in aggrecan structure modulate its susceptibility to aggrecanases.
The Biochemical journal 2003;375(Pt 1):183-9.
2003: Czipri Mátyás; Otto Jeffrey M; Cs-Szabó Gabriella; Kamath Rajesh V; Vermes Csaba; Firneisz Gábor; Kolman Kevin J; Watanabe Hideto; Li Yefu; Roughley Peter J; Yamada Yoshihiko; Olsen Björn R; Glant Tibor T
Genetic rescue of chondrodysplasia and the perinatal lethal effect of cartilage link protein deficiency.
The Journal of biological chemistry 2003;278(40):39214-23.
2003: Roughley P J; Rauch F; Glorieux F H
Osteogenesis imperfecta--clinical and molecular diversity.
European cells & materials 2003;5():41-7; discussion 47.
2003: Roughley Peter J; El-Maadawy Sherif
The use of biochemical markers of bone and cartilage metabolism to monitor osteoarthritis--dreams and reality.
The Journal of rheumatology 2003;30(5):910-2.
2003: Mwale Fackson; Demers Caroline N; Petit Alain; Roughley Peter; Poole A Robin; Steffen Thomas; Aebi Max; Antoniou John
A synthetic peptide of link protein stimulates the biosynthesis of collagens II, IX and proteoglycan by cells of the intervertebral disc.
Journal of cellular biochemistry 2003;88(6):1202-13.
2003: Burton-Wurster N; Liu W; Matthews G L; Lust G; Roughley P J; Glant T T; Cs-Szabó G
TGF beta 1 and biglycan, decorin, and fibromodulin metabolism in canine cartilage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2003;11(3):167-76.
2003: Alini Mauro; Li Wei; Markovic Paul; Aebi Max; Spiro Robert C; Roughley Peter J
The potential and limitations of a cell-seeded collagen/hyaluronan scaffold to engineer an intervertebral disc-like matrix.
Spine 2003;28(5):446-54; discussion 453.
2003: Troup Sandra; Njue Catherine; Kliewer Erich V; Parisien Michelle; Roskelley Cal; Chakravarti Shukti; Roughley Peter J; Murphy Leigh C; Watson Peter H
Reduced expression of the small leucine-rich proteoglycans, lumican, and decorin is associated with poor outcome in node-negative invasive breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(1):207-14.
2002: Roughley P J; Alini M; Antoniou J
The role of proteoglycans in aging, degeneration and repair of the intervertebral disc.
Biochemical Society transactions 2002;30(Pt 6):869-74.
2002: Alini M; Roughley P J; Antoniou J; Stoll T; Aebi M
A biological approach to treating disc degeneration: not for today, but maybe for tomorrow.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2002;11 Suppl 2():S215-20.
2002: Venkatesan Narayanan; Roughley Peter J; Ludwig Mara S
Proteoglycan expression in bleomycin lung fibroblasts: role of transforming growth factor-beta(1) and interferon-gamma.
American journal of physiology. Lung cellular and molecular physiology 2002;283(4):L806-14.
2002: Glant Tibor T; Kamath Rajesh V; Bárdos Tamás; Gál István; Szántó Sándor; Murad Yanal M; Sandy John D; Mort John S; Roughley Peter J; Mikecz Katalin
Cartilage-specific constitutive expression of TSG-6 protein (product of tumor necrosis factor alpha-stimulated gene 6) provides a chondroprotective, but not antiinflammatory, effect in antigen-induced arthritis.
Arthritis and rheumatism 2002;46(8):2207-18.
2002: Labuda M; Morissette J; Ward L M; Rauch F; Lalic L; Roughley P J; Glorieux F H
Osteogenesis imperfecta type VII maps to the short arm of chromosome 3.
Bone 2002;31(1):19-25.
2002: Ward L M; Rauch F; Travers R; Chabot G; Azouz E M; Lalic L; Roughley P J; Glorieux F H
Osteogenesis imperfecta type VII: an autosomal recessive form of brittle bone disease.
Bone 2002;31(1):12-8.
2002: Raouf Afshin; Ganss Bernhard; McMahon Chris; Vary Calvin; Roughley Peter J; Seth Arun
Lumican is a major proteoglycan component of the bone matrix.
Matrix biology : journal of the International Society for Matrix Biology 2002;21(4):361-7.
2002: Sztrolovics Robert; Grover Judy; Cs-Szabo Gabriella; Shi Shui-Liang; Zhang Yiping; Mort John S; Roughley Peter J
The characterization of versican and its message in human articular cartilage and intervertebral disc.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2002;20(2):257-66.
2002: Sztrolovics Robert; Recklies Anneliese D; Roughley Peter J; Mort John S
Hyaluronate degradation as an alternative mechanism for proteoglycan release from cartilage during interleukin-1beta-stimulated catabolism.
The Biochemical journal 2002;362(Pt 2):473-9.
2002: Sztrolovics Robert; White Robert J; Roughley Peter J; Mort John S
The mechanism of aggrecan release from cartilage differs with tissue origin and the agent used to stimulate catabolism.
The Biochemical journal 2002;362(Pt 2):465-72.
2002: Glorieux Francis H; Ward Leanne M; Rauch Frank; Lalic Ljiljana; Roughley Peter J; Travers Rose
Osteogenesis imperfecta type VI: a form of brittle bone disease with a mineralization defect.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002;17(1):30-8.
2001: Grover J; Roughley P J
Characterization and expression of murine PRELP.
Matrix biology : journal of the International Society for Matrix Biology 2001;20(8):555-64.
2001: Ward L M; Lalic L; Roughley P J; Glorieux F H
Thirty-three novel COL1A1 and COL1A2 mutations in patients with osteogenesis imperfecta types I-IV.
Human mutation 2001;17(5):434.
2001: Recklies A D; White C; Melching L; Roughley P J
Differential regulation and expression of hyaluronan synthases in human articular chondrocytes, synovial cells and osteosarcoma cells.
The Biochemical journal 2001;354(Pt 1):17-24.
2001: Al Jamal R; Roughley P J; Ludwig M S
Effect of glycosaminoglycan degradation on lung tissue viscoelasticity.
American journal of physiology. Lung cellular and molecular physiology 2001;280(2):L306-15.
2001: Alini M; Roughley P J
Changes in leucine-rich repeat proteoglycans during maturation of the bovine growth plate.
Matrix biology : journal of the International Society for Matrix Biology 2001;19(8):805-13.
2000: Grover J; Liu C Y; Kao W W; Roughley P J
Analysis of the human lumican gene promoter.
The Journal of biological chemistry 2000;275(52):40967-73.
2000: Leygue E; Snell L; Dotzlaw H; Troup S; Hiller-Hitchcock T; Murphy L C; Roughley P J; Watson P H
Lumican and decorin are differentially expressed in human breast carcinoma.
The Journal of pathology 2000;192(3):313-20.
2000: Glorieux F H; Rauch F; Plotkin H; Ward L; Travers R; Roughley P; Lalic L; Glorieux D F; Fassier F; Bishop N J
Type V osteogenesis imperfecta: a new form of brittle bone disease.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2000;15(9):1650-8.
2000: Scott I C; Imamura Y; Pappano W N; Troedel J M; Recklies A D; Roughley P J; Greenspan D S
Bone morphogenetic protein-1 processes probiglycan.
The Journal of biological chemistry 2000;275(39):30504-11.
2000: Venkatesan N; Ebihara T; Roughley P J; Ludwig M S
Alterations in large and small proteoglycans in bleomycin-induced pulmonary fibrosis in rats.
American journal of respiratory and critical care medicine 2000;161(6):2066-73.
1999: Little C B; Flannery C R; Hughes C E; Mort J S; Roughley P J; Dent C; Caterson B
Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro.
The Biochemical journal 1999;344 Pt 1():61-8.
1999: Sztrolovics R; Alini M; Mort J S; Roughley P J
Age-related changes in fibromodulin and lumican in human intervertebral discs.
Spine 1999;24(17):1765-71.
1999: Melching L I; Roughley P J
Modulation of keratan sulfate synthesis on lumican by the action of cytokines on human articular chondrocytes.
Matrix biology : journal of the International Society for Matrix Biology 1999;18(4):381-90.
1999: West L A; Roughley P; Nelson F R; Plaas A H
Sulphation heterogeneity in the trisaccharide (GalNAcSbeta1, 4GlcAbeta1,3GalNAcS) isolated from the non-reducing terminal of human aggrecan chondroitin sulphate.
The Biochemical journal 1999;342 ( Pt 1)():223-9.
1999: Sztrolovics R; White R J; Poole A R; Mort J S; Roughley P J
Resistance of small leucine-rich repeat proteoglycans to proteolytic degradation during interleukin-1-stimulated cartilage catabolism.
The Biochemical journal 1999;339 ( Pt 3)():571-7.
1998: Grover J; Roughley P J
Characterization of the human proline/arginine-rich end leucine-rich repeat protein (PRELP) gene promoter and identification of a repressor element.
The Biochemical journal 1998;336 ( Pt 1)():77-82.
1998: Dolhnikoff M; Morin J; Roughley P J; Ludwig M S
Expression of lumican in human lungs.
American journal of respiratory cell and molecular biology 1998;19(4):582-7.
1998: Leygue E; Snell L; Dotzlaw H; Hole K; Hiller-Hitchcock T; Roughley P J; Watson P H; Murphy L C
Expression of lumican in human breast carcinoma.
Cancer research 1998;58(7):1348-52.
1997: Sztrolovics R; Alini M; Roughley P J; Mort J S
Aggrecan degradation in human intervertebral disc and articular cartilage.
The Biochemical journal 1997;326 ( Pt 1)():235-41.
1997: Candeliere G A; Roughley P J; Glorieux F H
Polymerase chain reaction-based technique for the selective enrichment and analysis of mosaic arg201 mutations in G alpha s from patients with fibrous dysplasia of bone.
Bone 1997;21(2):201-6.
1997: Plaas A H; Wong-Palms S; Roughley P J; Midura R J; Hascall V C
Chemical and immunological assay of the nonreducing terminal residues of chondroitin sulfate from human aggrecan.
The Journal of biological chemistry 1997;272(33):20603-10.
1997: Cs-Szabó G; Melching L I; Roughley P J; Glant T T
Changes in messenger RNA and protein levels of proteoglycans and link protein in human osteoarthritic cartilage samples.
Arthritis and rheumatism 1997;40(6):1037-45.
1997: Melching L I; Cs-Szabo G; Roughley P J
Analysis of proteoglycan messages in human articular cartilage by a competitive PCR technique.
Matrix biology : journal of the International Society for Matrix Biology 1997;16(1):1-11.
1996: Grover J; Chen X N; Korenberg J R; Recklies A D; Roughley P J
The gene organization, chromosome location, and expression of a 55-kDa matrix protein (PRELP) of human articular cartilage.
Genomics 1996;38(2):109-17.
1996: Roughley P J; White R J; Cs-Szabó G; Mort J S
Changes with age in the structure of fibromodulin in human articular cartilage.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1996;4(3):153-61.
1996: Poole A R; Rosenberg L C; Reiner A; Ionescu M; Bogoch E; Roughley P J
Contents and distributions of the proteoglycans decorin and biglycan in normal and osteoarthritic human articular cartilage.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1996;14(5):681-9.
1996: Roughley P J; White R J; Mort J S
Presence of pro-forms of decorin and biglycan in human articular cartilage.
The Biochemical journal 1996;318 ( Pt 3)():779-84.
1996: Hollander A P; Heathfield T F; Liu J J; Pidoux I; Roughley P J; Mort J S; Poole A R
Enhanced denaturation of the alpha (II) chains of type-II collagen in normal adult human intervertebral discs compared with femoral articular cartilage.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1996;14(1):61-6.
1995: Roughley P J; Rodriguez E; Lee E R
The interactions of 'non-aggregating' proteoglycans.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1995;3(4):239-48.
1995: Grover J; Chen X N; Korenberg J R; Roughley P J
The human lumican gene. Organization, chromosomal location, and expression in articular cartilage.
The Journal of biological chemistry 1995;270(37):21942-9.
1995: Grover J; Roughley P J
Expression of cell-surface proteoglycan mRNA by human articular chondrocytes.
The Biochemical journal 1995;309 ( Pt 3)():963-8.
1995: Cs-Szabó G; Roughley P J; Plaas A H; Glant T T
Large and small proteoglycans of osteoarthritic and rheumatoid articular cartilage.
Arthritis and rheumatism 1995;38(5):660-8.
1994: Sztrolovics R; Chen X N; Grover J; Roughley P J; Korenberg J R
Localization of the human fibromodulin gene (FMOD) to chromosome 1q32 and completion of the cDNA sequence.
Genomics 1994;23(3):715-7.
1994: Grover J; Roughley P J
The expression of functional link protein in a baculovirus system: analysis of mutants lacking the A, B and B' domains.
The Biochemical journal 1994;300 ( Pt 2)():317-24.
1994: Sztrolovics R; Glorieux F H; Travers R; van der Rest M; Roughley P J
Osteogenesis imperfecta: comparison of molecular defects with bone histological changes.
Bone 1994;15(3):321-8.
1994: Sztrolovics R; van der Rest M; Roughley P J
Identification of type I collagen gene polymorphisms: tolerance of sequence variation at an alpha 2(I) helix Y position.
Matrix biology : journal of the International Society for Matrix Biology 1994;14(1):9-19.
1994: Roughley P J; Melching L I; Recklies A D
Changes in the expression of decorin and biglycan in human articular cartilage with age and regulation by TGF-beta.
Matrix biology : journal of the International Society for Matrix Biology 1994;14(1):51-9.
1993: Roughley P J; White R J; Magny M C; Liu J; Pearce R H; Mort J S
Non-proteoglycan forms of biglycan increase with age in human articular cartilage.
The Biochemical journal 1993;295 ( Pt 2)():421-6.
1993: Sztrolovics R; Glorieux F H; van der Rest M; Roughley P J
Identification of type I collagen gene (COL1A2) mutations in nonlethal osteogenesis imperfecta.
Human molecular genetics 1993;2(8):1319-21.
1993: Korenberg J R; Chen X N; Doege K; Grover J; Roughley P J
Assignment of the human aggrecan gene (AGC1) to 15q26 using fluorescence in situ hybridization analysis.
Genomics 1993;16(2):546-8.
1993: Grover J; Roughley P J
Versican gene expression in human articular cartilage and comparison of mRNA splicing variation with aggrecan.
The Biochemical journal 1993;291 ( Pt 2)():361-7.
1992: Roughley P J; White R J
The dermatan sulfate proteoglycans of the adult human meniscus.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1992;10(5):631-7.
1992: Nguyen Q; Mort J S; Roughley P J
Preferential mRNA expression of prostromelysin relative to procollagenase and in situ localization in human articular cartilage.
The Journal of clinical investigation 1992;89(4):1189-97.
1991: Nguyen Q; Liu J; Roughley P J; Mort J S
Link protein as a monitor in situ of endogenous proteolysis in adult human articular cartilage.
The Biochemical journal 1991;278 ( Pt 1)():143-7.
1991: Liu J; Roughley P J; Mort J S
Identification of human intervertebral disc stromelysin and its involvement in matrix degradation.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1991;9(4):568-75.
1990: Melching L I; Roughley P J
A matrix protein of Mr 55,000 that accumulates in human articular cartilage with age.
Biochimica et biophysica acta 1990;1036(3):213-20.
1990: Melching L I; Roughley P J
Studies on the interaction of newly secreted proteoglycan subunits with hyaluronate in human articular cartilage.
Biochimica et biophysica acta 1990;1035(1):20-8.
1990: Nguyen Q; Mort J S; Roughley P J
Cartilage proteoglycan aggregate is degraded more extensively by cathepsin L than by cathepsin B.
The Biochemical journal 1990;266(2):569-73.
1989: Campbell I K; Guttman A; Golds E E; Roughley P J; Mort J S
Variation in the effects of mononuclear cell products from different individuals on metalloproteinase secretion from human articular cartilage.
The Journal of rheumatology 1989;16(12):1552-8.
1989: Roughley P J; White R J
Dermatan sulphate proteoglycans of human articular cartilage. The properties of dermatan sulphate proteoglycans I and II.
The Biochemical journal 1989;262(3):823-7.
1989: Melching L I; Roughley P J
The synthesis of dermatan sulphate proteoglycans by fetal and adult human articular cartilage.
The Biochemical journal 1989;261(2):501-8.
1989: Poole A R; Webber C; Reiner A; Roughley P J
Studies of a monoclonal antibody to skeletal keratan sulphate. Importance of antibody valency.
The Biochemical journal 1989;260(3):849-56.
1989: Roberts C R; Roughley P J; Mort J S
Degradation of human proteoglycan aggregate induced by hydrogen peroxide. Protein fragmentation, amino acid modification and hyaluronic acid cleavage.
The Biochemical journal 1989;259(3):805-11.
1989: Nguyen Q; Murphy G; Roughley P J; Mort J S
Degradation of proteoglycan aggregate by a cartilage metalloproteinase. Evidence for the involvement of stromelysin in the generation of link protein heterogeneity in situ.
The Biochemical journal 1989;259(1):61-7.
1989: Pearce R H; Mathieson J M; Mort J S; Roughley P J
Effect of age on the abundance and fragmentation of link protein of the human intervertebral disc.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1989;7(6):861-7.
1987: Webber C; Glant T T; Roughley P J; Poole A R
The identification and characterization of two populations of aggregating proteoglycans of high buoyant density isolated from post-natal human articular cartilages of different ages.
The Biochemical journal 1987;248(3):735-40.
1987: Mort J S; Campbell I K; Guttman A; Golds E E; Roughley P J
The role of mononuclear cell products as modulators of cartilage degradation.
The Journal of rheumatology 1987;14 Spec No():86-7.
1986: Campbell I K; Roughley P J; Mort J S
The action of human articular-cartilage metalloproteinase on proteoglycan and link protein. Similarities between products of degradation in situ and in vitro.
The Biochemical journal 1986;237(1):117-22.
1986: Campbell I K; Golds E E; Mort J S; Roughley P J
Human articular cartilage secretes characteristic metal dependent proteinases upon stimulation by mononuclear cell factor.
The Journal of rheumatology 1986;13(1):20-7.
1986: Campbell I K; Mort J S; Golds E E; Roughley P J
Mononuclear cell factor modulates the concomitant release of proteoglycan and latent proteinase by human articular cartilage in organ culture.
Agents and actions. Supplements 1986;18():43-6.
1985: Melching L I; Roughley P J
The role of link protein in mediating the interaction between hyaluronic acid and newly secreted proteoglycan subunits from adult human articular cartilage.
The Journal of biological chemistry 1985;260(30):16279-85.
1984: Armour P C; Levi S; Golds E E; Poole A R; Mort J S; Roughley P J
Activation of latent collagenase by serum proteinases that interact with immobilized immunoglobulin G.
Rheumatology international 1984;4(4):151-5.
1983: Golds E E; Santer V; Killackey J; Roughley P J
Mononuclear cell factors stimulate the concomitant secretion of distinct latent proteoglycan, gelatin and collagen degrading enzymes from human skin fibroblasts and synovial cells.
The Journal of rheumatology 1983;10(6):861-71.
1983: Paquin J D; van der Rest M; Marie P J; Mort J S; Pidoux I; Poole A R; Roughley P J
Biochemical and morphologic studies of cartilage from the adult human sacroiliac joint.
Arthritis and rheumatism 1983;26(7):887-95.
1982: Santer V; White R J; Roughley P J
O-Linked oligosaccharides of human articular cartilage proteoglycan.
Biochimica et biophysica acta 1982;716(3):277-82.
1981: Roughley P J; White R J; Santer V
Comparison of proteoglycans extracted from high and low weight-bearing human articular cartilage, with particular reference to sialic acid content.
The Journal of biological chemistry 1981;256(24):12699-704.
1981: Roughley P J; McNicol D; Santer V; Buckwalter J
The presence of a cartilage-like proteoglycan in the adult human meniscus.
The Biochemical journal 1981;197(1):77-83.
1981: Santer V; White R J; Roughley P J
Proteoglycans from normal and degenerate cartilage of the adult human tibial plateau.
Arthritis and rheumatism 1981;24(5):691-700.

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