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William Roush

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
7
Hansell, Elizabeth
7
McKerrow, James
5
Scheidt, Karl
5
Frank, Scott
5
Alvarez-Hernandez, Alejandro
4
Dineen, Thomas
4
Flamme, Eric
4
Mergott, Dustin
4
Tinsley, Jennifer
4
Micalizio, Glenn C.
4
Savall, Brad
3
Wendt, Michael
3
Va, Porino
3
Shotwell, Brad
3
Holson, Edward

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Publications

TOP 3
Kister Jeremy; DeBaillie Amy C; Lira Ricardo; Roush William R
Stereoselective synthesis of gamma-substituted (Z)-allylic boranes via kinetically controlled hydroboration of allenes with 10-TMS-9-borabicyclo[3.3.2]decane.
Li Fangzheng; Roush William R
Stereoselective synthesis of syn,syn- and syn,anti-1,3,5-triols via intramolecular hydrosilylation of substituted pent-3-en-1,5-diols.
Dunetz Joshua R; Julian Lisa D; Newcom Jason S; Roush William R
Total syntheses of (+)-tedanolide and (+)-13-deoxytedanolide.

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All Publications

2009: Kister Jeremy; DeBaillie Amy C; Lira Ricardo; Roush William R
Stereoselective synthesis of gamma-substituted (Z)-allylic boranes via kinetically controlled hydroboration of allenes with 10-TMS-9-borabicyclo[3.3.2]decane.
Journal of the American Chemical Society 2009;131(40):14174-5.
2009: Li Fangzheng; Roush William R
Stereoselective synthesis of syn,syn- and syn,anti-1,3,5-triols via intramolecular hydrosilylation of substituted pent-3-en-1,5-diols.
Organic letters 2009;11(13):2932-5.
2008: Dunetz Joshua R; Julian Lisa D; Newcom Jason S; Roush William R
Total syntheses of (+)-tedanolide and (+)-13-deoxytedanolide.
Journal of the American Chemical Society 2008;130(48):16407-16.
2008: Tortosa Mariola; Yakelis Neal A; Roush William R
Total synthesis of (+)-superstolide A.
The Journal of organic chemistry 2008;73(24):9657-67.
2008: Bates Robert H; Shotwell J Brad; Roush William R
Stereoselective syntheses of the C(1)-C(9) fragment of amphidinolide C.
Organic letters 2008;10(19):4343-6.
2008: Dunetz Joshua R; Roush William R
Concerning the synthesis of the tedanolide C(13)-C(23) fragment via anti-aldol reaction.
Organic letters 2008;10(10):2059-62.
2008: Tortosa Mariola; Yakelis Neal A; Roush William R
Total synthesis of +-superstolide A.
Journal of the American Chemical Society 2008;130(9):2722-3.
2008: Winbush SusAnn M; Mergott Dustin J; Roush William R
Total synthesis of (-)-spinosyn A: examination of structural features that govern the stereoselectivity of the key transannular Diels-Alder reaction.
The Journal of organic chemistry 2008;73(5):1818-29.
2008: Hicks Jacqueline D; Roush William R
Synthesis of the C(26)-C(42) and C(43)-C(67) pyran-containing fragments of amphidinol 3 via a common pyran intermediate.
Organic letters 2008;10(4):681-4.
2008: Handa Masaki; Smith William J; Roush William R
Studies on the synthesis of apoptolidin A. 2. Synthesis of the disaccharide unit.
The Journal of organic chemistry 2008;73(3):1036-9.
2008: Handa Masaki; Scheidt Karl A; Bossart Martin; Zheng Nan; Roush William R
Studies on the synthesis of apoptolidin A. 1. Synthesis of the C(1)-C(11) fragment.
The Journal of organic chemistry 2008;73(3):1031-5.
2007: Hicks Jacqueline D; Huh Chan Woo; Legg Ashley D; Roush William R
Concerning the selective protection of (Z)-1,5-syn-ene-diols and (E)-1,5-anti-ene-diols as allylic triethylsilyl ethers.
Organic letters 2007;9(26):5621-4.
2007: Lira Ricardo; Roush William R
Enantio- and diastereoselective synthesis of syn-beta-hydroxyallylsilanes via a chiral (Z)-gamma-silylallylboronate.
Organic letters 2007;9(21):4315-8.
2007: Goetz D H; Choe Y; Hansell E; Chen Y T; McDowell M; Jonsson C B; Roush W R; McKerrow J; Craik C S
Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus.
Biochemistry 2007;46(30):8744-52.
2007: Meléndez-López Samuel G; Herdman Scott; Hirata Ken; Choi Min-Ho; Choe Youngchool; Craik Charles; Caffrey Conor R; Hansell Elisabeth; Chávez-Munguía Bibiana; Chen Yen Ting; Roush William R; McKerrow James; Eckmann Lars; Guo Jianhua; Stanley Samuel L; Reed Sharon L
Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model.
Eukaryotic cell 2007;6(7):1130-6.
2007: Lira Ricardo; Roush William R
Stereoselective synthesis of the C(1)-C(19) fragment of tetrafibricin.
Organic letters 2007;9(3):533-6.
2007: Va Porino; Roush William R
Synthesis of 2-epi-amphidinolide E: an unexpected and highly selective C(2)inversion during an esterification reaction.
Organic letters 2007;9(2):307-10.
2006: Va Porino; Roush William R
Total synthesis of amphidinolide E.
Journal of the American Chemical Society 2006;128(50):15960-1.
2006: Trullinger Tony K; Qi Jun; Roush William R
Studies on the synthesis of quartromicins a(3) and d(3): synthesis of the vertical and horizontal bis-spirotetronate fragments.
The Journal of organic chemistry 2006;71(18):6915-22.
2006: Qi Jun; Roush William R
Synthesis of precursors of the agalacto (exo) fragment of the quartromicins via an auxiliary-controlled exo-selective Diels-Alder reaction.
Organic letters 2006;8(13):2795-8.
2005: Thalji Reema K; Roush William R
Remarkable phosphine-effect on the intramolecular aldol reactions of unsaturated 1,5-diketones: highly regioselective synthesis of cross-conjugated dienones.
Journal of the American Chemical Society 2005;127(48):16778-9.
2005: Hicks Jacqueline D; Flamme Eric M; Roush William R
Synthesis of the C(43)-C(67) fragment of amphidinol 3.
Organic letters 2005;7(24):5509-12.
2005: Lambert William T; Roush William R
Synthesis of the A-B subunit of angelmicin B.
Organic letters 2005;7(24):5501-4.
2005: Mertz Eric; Tinsley Jennifer M; Roush William R
[3 + 2]-annulation reactions of chiral allylsilanes and chiral aldehydes. studies on the synthesis of bis-tetrahydrofuran substructures of annonaceous acetogenins.
The Journal of organic chemistry 2005;70(20):8035-46.
2005: Tinsley Jennifer M; Mertz Eric; Chong Pek Y; Rarig Robert-André F; Roush William R
Synthesis of (+)-bullatacin via the highly diastereoselective [3+2] annulation reaction of a racemic aldehyde and a nonracemic allylsilane.
Organic letters 2005;7(19):4245-8.
2005: Owen Robert M; Roush William R
Stereoselective synthesis of the C(1)-C(11) fragment of peloruside A.
Organic letters 2005;7(18):3941-4.
2005: Tinsley Jennifer M; Roush William R
Total synthesis of asimicin via highly stereoselective [3 + 2] annulation reactions of substituted allylsilanes.
Journal of the American Chemical Society 2005;127(31):10818-9.
2005: Heitzman Cheryl L; Lambert William T; Mertz Eric; Shotwell J Brad; Tinsley Jennifer M; Va Porino; Roush William R
Efficient protiodesilylation of unactivated C(sp3)-SiMe2Ph bonds using tetrabutylammonium fluoride.
Organic letters 2005;7(12):2405-8.
2005: Julian Lisa D; Newcom Jason S; Roush William R
Total synthesis of (+)-13-deoxytedanolide.
Journal of the American Chemical Society 2005;127(17):6186-7.
2005: Liu Christopher M; Smith William J; Gustin Darin J; Roush William R
Experimental evidence for chair-like transition states in aldol reactions of methyl ketone lithium enolates: stereoselective synthesis and utilization of a deuterium-labeled enolate as a probe of reaction stereochemistry.
Journal of the American Chemical Society 2005;127(16):5770-1.
2005: Flamme Eric M; Roush William R
Synthesis of the C(1)-C(25) fragment of amphidinol 3: application of the double-allylboration reaction for synthesis of 1,5-diols.
Organic letters 2005;7(7):1411-4.
2005: Dineen Thomas A; Roush William R
Stereoselective synthesis of the octahydronaphthalene unit of integramycin via an intramolecular Diels-Alder reaction.
Organic letters 2005;7(7):1355-8.
2005: Flamme Eric M; Roush William R
Synthesis of 2,6-trans-disubstituted 5,6-dihydropyrans from (Z)-1,5-syn-endiols.
Beilstein journal of organic chemistry 2005;1(1):7.
2004: Shotwell J Brad; Roush William R
Synthesis of the C11-C29 fragment of amphidinolide F.
Organic letters 2004;6(21):3865-8.
2004: Narayan Sridhar; Roush William R
Studies toward the total synthesis of angelmicin B (hibarimicin B): synthesis of a model CD-D' arylnaphthoquinone.
Organic letters 2004;6(21):3789-92.
2004: Durham Timothy B; Blanchard Nicolas; Savall Brad M; Powell Noel A; Roush William R
Total synthesis of formamicin.
Journal of the American Chemical Society 2004;126(30):9307-17.
2004: Mergott Dustin J; Frank Scott A; Roush William R
Total synthesis of (-)-spinosyn A.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(33):11955-9.
2004: Roush William R; Neitz R Jeffrey
Studies on the synthesis of landomycin A. Synthesis of the originally assigned structure of the aglycone, landomycinone, and revision of structure.
The Journal of organic chemistry 2004;69(15):4906-12.
2004: Dineen Thomas A; Roush William R
Total synthesis of cochleamycin A.
Organic letters 2004;6(12):2043-6.
2003: Dineen Thomas A; Roush William R
Probing the Lewis acid-catalyzed intramolecular Diels-Alder cyclizations of allylic alkoxy-substituted (Z)-1,3-dienes.
Organic letters 2003;5(24):4725-8.
2003: Methot Joey L; Roush William R
Synthetic studies toward FR182877. Remarkable solvent effect in the vinylogous morita-baylis-hillman cyclization.
Organic letters 2003;5(22):4223-6.
2003: Boitano Anthony; Emal Cory D; Leonetti Francesco; Blatt Neal B; Dineen Thomas A; Ellman Jonathan A; Roush William R; Opipari Anthony W; Glick Gary D
Structure activity studies of a novel cytotoxic benzodiazepine.
Bioorganic & medicinal chemistry letters 2003;13(19):3327-30.
2003: Reddick Jason J; Cheng Jianming; Roush William R
Relative rates of Michael reactions of 2'-(phenethyl)thiol with vinyl sulfones, vinyl sulfonate esters, and vinyl sulfonamides relevant to vinyl sulfonyl cysteine protease inhibitors.
Organic letters 2003;5(11):1967-70.
2003: Durham Timothy B; Roush William R
Stereoselective synthesis of functionalized precursors of the CDEF and CDE 2,6-dideoxy-tetra- and trisaccharide units of durhamycins A and B.
Organic letters 2003;5(11):1875-8.
2003: Durham Timothy B; Roush William R
Stereoselective synthesis of 2-deoxy-beta-galactosides via 2-deoxy-2-bromo- and 2-deoxy-2-iodo-galactopyranosyl donors.
Organic letters 2003;5(11):1871-4.
2003: Yakelis Neal A; Roush William R
Synthesis of the C(21)-C(26) fragment of superstolide A: concerning the stereochemistry of (E)-crotylboration reactions of alaninal derivatives.
The Journal of organic chemistry 2003;68(10):3838-43.
2003: Heo Jung-Nyoung; Holson Edward B; Roush William R
Common-intermediate strategy for synthesis of conduritols and inositols via beta-hydroxy cyclohexenylsilanes.
Organic letters 2003;5(10):1697-700.
2003: Heo Jung-Nyoung; Micalizio Glenn C; Roush William R
Enantio- and diastereoselective synthesis of cyclic beta-hydroxy allylsilanes via sequential aldehyde gamma-silylallylboration and ring-closing metathesis reactions.
Organic letters 2003;5(10):1693-6.
2003: Chemler Sherry R; Roush William R
Stereochemistry of the allylation and crotylation reactions of alpha-methyl-beta-hydroxy aldehydes with allyl- and crotyltrifluorosilanes. Synthesis of anti,anti-dipropionate stereotriads and stereodivergent pathways for the reactions with 2,3-anti- and 2,3-syn-alpha-methyl-beta-hydroxy aldehydes.
The Journal of organic chemistry 2003;68(4):1319-33.
2003: Savall Brad M; Blanchard Nicolas; Roush William R
Total synthesis of the formamicin aglycon, formamicinone.
Organic letters 2003;5(3):377-9.
2003: Blanchard Nicolas; Roush William R
2-Deoxy-2-iodo-beta-glucopyranosyl fluorides: mild and highly stereoselective glycosyl donors for the synthesis of 2-deoxy-beta-glycosides from beta-hydroxy ketones.
Organic letters 2003;5(1):81-4.
2003: Shenai Bhaskar R; Lee Belinda J; Alvarez-Hernandez Alejandro; Chong Pek Y; Emal Cory D; Neitz R Jeffrey; Roush William R; Rosenthal Philip J
Structure-activity relationships for inhibition of cysteine protease activity and development of Plasmodium falciparum by peptidyl vinyl sulfones.
Antimicrobial agents and chemotherapy 2003;47(1):154-60.
2002: Roush William R; Newcom Jason S
Studies on the synthesis of tedanolide. 2. Stereoselective synthesis of a protected C(1)-C(12) fragment.
Organic letters 2002;4(26):4739-42.
2002: Chong Pek Y; Roush William R
Concerning the origin of the high beta-selectivity of glycosidation reactions of 2-deoxy-2-iodo-glucopyranosyl trichloroacetimidates.
Organic letters 2002;4(25):4523-6.
2002: Flamme Eric M; Roush William R
Enantioselective synthesis of 1,5-anti- and 1,5-syn-diols using a highly diastereoselective one-pot double allylboration reaction sequence.
Journal of the American Chemical Society 2002;124(46):13644-5.
2002: Holson Edward B; Roush William R
Synthesis of the C(2)-C(13) fragment (the A-B spiroketal unit) of spongistatin 1 (altohyrtin A): use of a common intermediate for the synthesis of both spongistatin spiroketals.
Organic letters 2002;4(21):3723-5.
2002: Holson Edward B; Roush William R
Diastereoselective synthesis of the C(17)-C(28) fragment (the C-D spiroketal unit) of spongistatin 1 (altohyrtin A) via a kinetically controlled iodo-spiroketalization reaction.
Organic letters 2002;4(21):3719-22.
2002: Gung Benjamin W; Xue Xiaowen; Roush William R
The origin of diastereofacial control in allylboration reactions using tartrate ester derived allylboronates: attractive interactions between the Lewis acid coordinated aldehyde carbonyl group and an ester carbonyl oxygen.
Journal of the American Chemical Society 2002;124(36):10692-7.
2002: Mergott Dustin J; Frank Scott A; Roush William R
Application of the intramolecular vinylogous Morita-Baylis-Hillman reaction toward the synthesis of the spinosyn A tricyclic nucleus.
Organic letters 2002;4(18):3157-60.
2002: Hernandez Alejandro Alvarez; Roush William R
Recent advances in the synthesis, design and selection of cysteine protease inhibitors.
Current opinion in chemical biology 2002;6(4):459-65.
2002: Scheidt Karl A; Bannister Thomas D; Tasaka Akihiro; Wendt Michael D; Savall Brad M; Fegley Glenn J; Roush William R
Total synthesis of (-)-bafilomycin A(1).
Journal of the American Chemical Society 2002;124(24):6981-90.
2002: Frank Scott A; Roush William R
Studies on the synthesis of (-)-spinosyn a: application of the steric directing group strategy to transannular Diels-Alder reactions.
The Journal of organic chemistry 2002;67(12):4316-24.
2002: Roush William R; Bannister Thomas D; Wendt Michael D; VanNieuwenhze Michael S; Gustin Darin J; Dilley Garrett J; Lane Gregory C; Scheidt Karl A; Smith William J
An NMR method for assigning relative stereochemistry to beta-hydroxy ketones deriving from aldol reactions of methyl ketones.
The Journal of organic chemistry 2002;67(12):4284-9.
2002: Roush William R; Bannister Thomas D; Wendt Michael D; Jablonowski Jill A; Scheidt Karl A
Studies on the synthesis of bafilomycin A(1): stereochemical aspects of the fragment assembly aldol reaction for construction of the C(13)-C25) segment.
The Journal of organic chemistry 2002;67(12):4275-83.
2002: Roush William R; Limberakis Chris; Kunz Roxanne K; Barda David A
Diastereoselective synthesis of the endo- and exo-spirotetronate subunits of the quartromicins. The first enantioselective Diels-Alder reaction of an acyclic (Z)-1,3-diene.
Organic letters 2002;4(9):1543-6.
2002: Roush William R; Barda David A
Partial stereochemical assignment of quartromicins A3 and D3.
Organic letters 2002;4(9):1539-42.
2002: Frank Scott A; Mergott Dustin J; Roush William R
The vinylogous intramolecular Morita-Baylis-Hillman reaction: synthesis of functionalized cyclopentenes and cyclohexenes with trialkylphosphines as nucleophilic catalysts.
Journal of the American Chemical Society 2002;124(11):2404-5.
2001: Caffrey C R; Hansell E; Lucas K D; Brinen L S; Alvarez Hernandez A; Cheng J; Gwaltney S L; Roush W R; Stierhof Y D; Bogyo M; Steverding D; McKerrow J H
Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense.
Molecular and biochemical parasitology 2001;118(1):61-73.
2001: Roush W R; Cheng J; Knapp-Reed B; Alvarez-Hernandez A; McKerrow J H; Hansell E; Engel J C
Potent second generation vinyl sulfonamide inhibitors of the trypanosomal cysteine protease cruzain.
Bioorganic & medicinal chemistry letters 2001;11(20):2759-62.
2001: Roush W R; Bennett C E; Roberts S E
Studies on the synthesis of landomycin A: synthesis and glycosidation reactions of L-rhodinosyl acetate derivatives.
The Journal of organic chemistry 2001;66(19):6389-93.
2001: Savall B M; Powell N A; Roush W R
Highly diastereoselective synthesis of propargylic 1,2-anti-diol derivatives using alpha-alkoxypropargylstannanes.
Organic letters 2001;3(19):3057-60.
2001: Micalizio G C; Roush W R
Studies on the synthesis of pectenotoxin II: synthesis of a C(11)-C(26) fragment precursor via [3 + 2]-annulation reactions of chiral allylsilanes.
Organic letters 2001;3(12):1949-52.
2001: Ménard R; Therrien C; Lachance P; Sulea T; Qo H; Alvarez-Hernandez A D; Roush W R
Cathepsins X and B display distinct activity profiles that can be exploited for inhibitor design.
Biological chemistry 2001;382(5):839-45.
2001: Yakelis N A; Roush W R
Lewis acid catalyzed intramolecular Diels-Alder reactions of acyclic (Z)-substituted 1,3-dienes.
Organic letters 2001;3(6):957-60.
2001: Therrien C; Lachance P; Sulea T; Purisima E O; Qi H; Ziomek E; Alvarez-Hernandez A; Roush W R; Ménard R
Cathepsins X and B can be differentiated through their respective mono- and dipeptidyl carboxypeptidase activities.
Biochemistry 2001;40(9):2702-11.
2001: Powell N A; Roush W R
Studies on the total synthesis of formamicin: synthesis of the C(1)-C(11) fragment.
Organic letters 2001;3(3):453-6.
2000: Micalizio G C; Pinchuk A N; Roush W R
Synthesis of the C(29)-C(45) bis-pyran subunit (E-F) of spongistatin 1 (Altohyrtin A).
The Journal of organic chemistry 2000;65(25):8730-6.
2000: Brinen L S; Hansell E; Cheng J; Roush W R; McKerrow J H; Fletterick R J
A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease.
Structure (London, England : 1993) 2000;8(8):831-40.
2000: Frank S A; Chen H; Kunz R K; Schnaderbeck M J; Roush W R
Use of thallium(I) ethoxide in Suzuki cross coupling reactions.
Organic letters 2000;2(17):2691-4.
2000: Roush W R; Pfeifer L A
Total synthesis of mycalamide A and 7-epi-mycalamide A.
Organic letters 2000;2(6):859-62.
2000: Micalizio G C; Roush W R
A three-component coupling strategy for tetrahydrofuran synthesis: application of the diisopropyl tartrate modified (E)-gamma-(dimethylphenylsilyl)allylboronate as an alpha,gamma-allyl dianion equivalent.
Organic letters 2000;2(4):461-4.
1999: Roush W R; Narayan S
2-Deoxy-2-iodo-alpha-mannopyranosyl and -talopyranosyl acetates: highly stereoselective glycosyl donors for the synthesis of 2-deoxy-alpha-glycosides.
Organic letters 1999;1(6):899-902.
1999: Roush W R; Narayan S; Bennett C E; Briner K
Iodoacetoxylation of glycals using cerium(IV) ammonium nitrate, sodium iodide, and acetic acid: stereoselective synthesis of 2-deoxy-2-iodo-alpha-mannopyranosyl acetates.
Organic letters 1999;1(6):895-7.
1999: Roush W R; Gung B W; Bennett C E
2-Deoxy-2-iodo- and 2-deoxy-2-bromo-alpha-glucopyranosyl trichloroacetimidates: highly reactive and stereoselective donors for the synthesis of 2-deoxy-beta-glycosides.
Organic letters 1999;1(6):891-3.
1999: Roush W R; Lane G C
Studies on the synthesis of tedanolide: synthesis of the C(5)-C(21) segment via a highly stereoselective fragment assembly aldol reaction of a chiral beta,gamma-unsaturated methyl ketone.
Organic letters 1999;1(1):95-8.
1998: Scheidt K A; Roush W R; McKerrow J H; Selzer P M; Hansell E; Rosenthal P J
Structure-based design, synthesis and evaluation of conformationally constrained cysteine protease inhibitors.
Bioorganic & medicinal chemistry 1998;6(12):2477-94.
1998: Roush W R; González F V; McKerrow J H; Hansell E
Design and synthesis of dipeptidyl alpha',beta'-epoxy ketones, potent irreversible inhibitors of the cysteine protease cruzain.
Bioorganic & medicinal chemistry letters 1998;8(19):2809-12.

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