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Sylvain Routier

Research Profile

Chemicals & Drugs

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Drug Screening Assays, Antitumor

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Tumor Cell Line

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Publications

TOP 3
Caroline West; Sylvain Routier; Alexis Bouet; Eric Lesellier
Effects of mobile phase composition and temperature on the supercritical fluid chromatography enantioseparation of chiral fluoro-oxoindole-type compounds with chlorinated polysaccharide stationary phases.
Rajâa Boulahjar; Stephane Bourg; Christiane Guguen-Guillouzo; Gérald Guillaumet; Saïd Lazar; Olivier Lozach; Séverine Marionneau; Chiurato Matteo; Laurent Meijer; Aziz Ouach; Thibauld Oullier; Myriam Ravache; Yves Troin; Rémy le Guével; Mohamed Akssira; Sylvain Routier
Novel tetrahydropyrido[1,2-a]isoindolone derivatives (valmerins): potent cyclin-dependent kinase/glycogen synthase kinase 3 inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts.
Hala Nehme; Reine Nehme; Sylvain Routier; Pierre Lafite; Philippe Morin
New development in in-capillary electrophoresis techniques for kinetic and inhibition study of enzymes.

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All Publications

2012: Caroline West; Sylvain Routier; Alexis Bouet; Eric Lesellier
Effects of mobile phase composition and temperature on the supercritical fluid chromatography enantioseparation of chiral fluoro-oxoindole-type compounds with chlorinated polysaccharide stationary phases.
Journal of chromatography. A 2012;1269():325-35.
2012: Rajâa Boulahjar; Stephane Bourg; Christiane Guguen-Guillouzo; Gérald Guillaumet; Saïd Lazar; Olivier Lozach; Séverine Marionneau; Chiurato Matteo; Laurent Meijer; Aziz Ouach; Thibauld Oullier; Myriam Ravache; Yves Troin; Rémy le Guével; Mohamed Akssira; Sylvain Routier
Novel tetrahydropyrido[1,2-a]isoindolone derivatives (valmerins): potent cyclin-dependent kinase/glycogen synthase kinase 3 inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts.
Journal of medicinal chemistry 2012;55(22):9589-606.
2012: Hala Nehme; Reine Nehme; Sylvain Routier; Pierre Lafite; Philippe Morin
New development in in-capillary electrophoresis techniques for kinetic and inhibition study of enzymes.
Analytica chimica acta 2012;722():127-35.
2012: Cleopatra Neagoie; Sorin Rosca; Emeline Vedrenne; Brigitte Baldeyrou; Stéphane Bourg; Frédéric Buron; Amélie Lansiaux; Olivier Lozach; Laurent Meijer; Jean-Yves Mérour; Sylvain Routier
Synthesis of chromeno[3,4-b]indoles as Lamellarin D analogues: a novel DYRK1A inhibitor class.
European journal of medicinal chemistry 2012;49():379-96.
2012: Yassine Riadi; Sylvain Routier; Rachid Mamouni; Younes Abrouki; Mohammadine El Haddad; Gérald Guillaumet; Saïd Lazar
New eco-friendly animal bone meal catalysts for preparation of chalcones and aza-Michael adducts.
Chemistry Central journal 2012;6(1):60.
2011: Pamela Kassis; Rémi Le Guével; Krzysztof Lewiński; Olivier Lozach; Laurent Meijer; Valérie Bénéteau; Stéphane Bourg; Joanna Brzeszcz; Lionel Colliandre; Christiane Guillouzo; Sylvain Routier; Jean-Yves Mérour
Synthesis and biological evaluation of new 3-(6-hydroxyindol-2-yl)-5-(Phenyl) pyridine or pyrazine V-Shaped molecules as kinase inhibitors and cytotoxic agents.
European journal of medicinal chemistry 2011;46(11):5416-34.
2010: Youssef Hajbi; Cléopatra Neagoie; Bérenger Biannic; Aurélie Chilloux; Emeline Vedrenne; Brigitte Baldeyrou; Christian Bailly; Jean-Yves Mérour; Sorin Rosca; Sylvain Routier; Amélie Lansiaux
Synthesis and biological activities of new furo[3,4-b]carbazoles: potential topoisomerase II inhibitors.
European journal of medicinal chemistry 2010;45(11):5428-37.
2010: Nathalie Ayerbe; Sylvain Routier; Isabelle Gillaizeau; Carmen Maiereanu; Daniel-Henri Caignard; Alain Pierré; Stéphane Léonce; Gérard Coudert
Synthesis and biological evaluation of novel benzodioxinocarbazoles (BDCZs) as potential anticancer agents.
Bioorganic & medicinal chemistry letters 2010;20(15):4670-4.
2010: Laurent Pellegatti; Emeline Vedrenne; Jean-Michel Leger; Christian Jarry; Sylvain Routier
Efficient pallado-catalyzed C6-(het)arylation of Imidazo[1,2-b][1,2,4,5]tetrazines under microwave irradiations.
Journal of combinatorial chemistry 2010;12(4):604-8.
2009: Abdellatif Tikad; Sylvain Routier; Mohamed Akssira; Gérald Guillaumet
Efficient one-pot synthesis of 2,4-di(het)aryl and 2,4-diamino pyrido[3,2-d]pyrimidines involving regioselective S(N)Ar and palladium-catalyzed reactions.
Organic & biomolecular chemistry 2009;7(24):5113-8.
2008: Aurélie Bourderioux; Valérie Bénéteau; Jean-Yves Mérour; Brigitte Baldeyrou; Caroline Ballot; Amélie Lansiaux; Christian Bailly; Rémy Le Guével; Christiane Guillouzo; Sylvain Routier
Synthesis and biological evaluation of novel oxophenylarcyriaflavins as potential anticancer agents.
Organic & biomolecular chemistry 2008;6(12):2108-17.
2008: Ulrich Jacquemard; Nathalie Dias; Amélie Lansiaux; Christian Bailly; Cédric Logé; Jean-Michel Robert; Olivier Lozach; Laurent Meijer; Jean-Yves Mérour; Sylvain Routier
Synthesis of 3,5-bis(2-indolyl)pyridine and 3-[(2-indolyl)-5-phenyl]pyridine derivatives as CDK inhibitors and cytotoxic agents.
Bioorganic & medicinal chemistry 2008;16(9):4932-53.
2008: Myriam Lefoix; Gérard Coudert; Sylvain Routier; Bruno Pfeiffer; Daniel-Henri Caignard; John Hickman; Alain Pierré; Roy M Golsteyn; Stéphane Léonce; Céline Bossard; Jean-Yves Mérour
Novel 5-azaindolocarbazoles as cytotoxic agents and Chk1 inhibitors.
Bioorganic & medicinal chemistry 2008;16(9):5303-21.
2007: Abdellatif Tikad; Sylvain Routier; Mohamed Akssira; Jean-Michel Leger; Christian Jarry; Gérald Guillaumet
New efficient route to dissymmetric 2,4-di(het)aryl-pyrido[3,2-d]pyrimidines via regioselective cross-coupling reactions.
Organic letters 2007;9(23):4673-6.
2007: Marie-Agnès Lassoie; Fabienne Broeders; Philippe Collart; Laurent Defrère; Françoise de Laveleye-Defais; Thierry Demaude; Abdoulaye Gassama; Gérald Guillaumet; Jean-Claude Hayez; Laszlo Kiss; Laurent Knerr; Jean-Marie Nicolas; Stéphanie Norsikian; Luc Quéré; Sylvain Routier; Valérie Verbois; Laurent Provins
2,6-Quinolinyl derivatives as potent VLA-4 antagonists.
Bioorganic & medicinal chemistry letters 2007;17(1):142-6.
2006: Sylvain Routier; Jean-Yves Mérour; Nathalie Dias; Amélie Lansiaux; Christian Bailly; Olivier Lozach; Laurent Meijer
Synthesis and biological evaluation of novel phenylcarbazoles as potential anticancer agents.
Journal of medicinal chemistry 2006;49(2):789-99.
2005: Nathalie Dias; Ulrich Jacquemard; Brigitte Baldeyrou; Amélie Lansiaux; Jean-François Goossens; Christian Bailly; Sylvain Routier; Jean-Yves Mérour
Synthesis of 2,6-diphenylpyrazine derivatives and their DNA binding and cytotoxic properties.
European journal of medicinal chemistry 2005;40(12):1206-13.
2005: Ulrich Jacquemard; Sylvain Routier; Nathalie Dias; Amélie Lansiaux; Jean-François Goossens; Christian Bailly; Jean-Yves Mérour
Synthesis of 2,5- and 3,5-diphenylpyridine derivatives for DNA recognition and cytotoxicity.
European journal of medicinal chemistry 2005;40(11):1087-95.
2005: Sylvain Routier; Paul Peixoto; Jean-Yves Mérour; Gérard Coudert; Nathalie Dias; Christian Bailly; Alain Pierré; Stéphane Léonce; Daniel-Henri Caignard
Synthesis and biological evaluation of novel naphthocarbazoles as potential anticancer agents.
Journal of medicinal chemistry 2005;48(5):1401-13.
2004: Nathalie Dias; Ulrich Jacquemard; Brigitte Baldeyrou; Christelle Tardy; Amélie Lansiaux; Pierre Colson; Farial A Tanious; David W. Wilson; Sylvain Routier; Jean-Yves Mérour; Christian Bailly
Targeting DNA with novel diphenylcarbazoles.
Biochemistry 2004;43(48):15169-78.
2004: Ulrich Jacquemard; Sylvain Routier; Arnaud Tatibouët; jerome kluza; William Laine; Christine Bal; Christian Bailly; Jean-Yves Mérour
Synthesis of diphenylcarbazoles as cytotoxic DNA binding agents.
Organic & biomolecular chemistry 2004;2(10):1476-83.
2002: Hervé Vezin; Eric Lamour; Sylvain Routier; Françoise Villain; Christian Bailly; Jean-Luc Bernier; Jean Pierre Catteau
Free radical production by hydroxy-salen manganese complexes studied by ESR and XANES.
Journal of inorganic biochemistry 2002;92(3-4):177-82.
2001: L B Nicolas; W Pinoteau; Sébastien Papot; Sylvain Routier; Gérald Guillaumet; Stéphane Mortaud
Aggressive behavior induced by the steroid sulfatase inhibitor COUMATE and by DHEAS in CBA/H mice.
Brain research 2001;922(2):216-22.
2001: Paola B Arimondo; Brigitte Baldeyrou; William Laine; Christine Bal; F A Alphonse; Sylvain Routier; Gérard Coudert; Jean-Yves Mérour; Pierre Colson; Claude Houssier; Christian Bailly
DNA interaction and cytotoxicity of a new series of indolo[2,3-b]quinoxaline and pyridopyrazino[2,3-b]indole derivatives.
Chemico-biological interactions 2001;138(1):59-75.
2001: B Joseph; Michaël Facompré; H Da Costa; Sylvain Routier; Jean-Yves Mérour; Pierre Colson; Claude Houssier; Christian Bailly
Synthesis, cytotoxicity, DNA interaction and topoisomerase II inhibition properties of tetrahydropyrrolo[3,4-a]carbazole-1,3-dione and tetrahydropyrido-[3,2-b]pyrrolo[3,4-g]indole-1,3-dione derivatives.
Bioorganic & medicinal chemistry 2001;9(6):1533-41.
2000: J Benoit; Sylvain Routier; Jean-Yves Mérour; Pierre Colson; Claude Houssier; Christian Bailly
DNA but not topoisomerases is a target for a cytotoxic benzo[5,6]cyclohepta[b]indol-6-one derivative.
Anticancer research 2000;20(5A):3307-14.
1999: Sylvain Routier; Hervé Vezin; Eric Lamour; Jean-Luc Bernier; Jean Pierre Catteau; Christian Bailly
DNA cleavage by hydroxy-salicylidene-ethylendiamine-iron complexes.
Nucleic acids research 1999;27(21):4160-6.
1998: Sylvain Routier; Jean-Luc Bernier; Jean Pierre Catteau; J F Riou; Christian Bailly
Synthesis, DNA binding, topoisomerase II inhibition and cytotoxicity of two guanidine-containing anthracene-9,10-diones.
Anti-cancer drug design 1998;13(5):407-15.
1997: Sylvain Routier; Jean-Luc Bernier; Jean Pierre Catteau; Pierre Colson; Claude Houssier; C Rivalle; E Bisagni; Christian Bailly
Synthesis, DNA binding, and cleaving properties of an ellipticine-salen.copper conjugate.
Bioconjugate chemistry 1997;8(6):789-92.
1996: Sylvain Routier; N Cotelle; Jean Pierre Catteau; Jean-Luc Bernier; M J Waring; J F Riou; Christian Bailly
Salen-anthraquinone conjugates. Synthesis, DNA-binding and cleaving properties, effects on topoisomerases and cytotoxicity.
Bioorganic & medicinal chemistry 1996;4(8):1185-96.
1996: Christian Bailly; Sylvain Routier; Jean-Luc Bernier; M J Waring
DNA recognition by two mitoxantrone analogues: influence of the hydroxyl groups.
FEBS letters 1996;379(3):269-72.