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Andrew Rowan

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Anatomy

Living Beings

Cattle

Phenomena

Drug Synergism

Physiology

Enzymologic Gene Expression Regulation

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Network (preview)

Co-Publications
Name
38
Cawston, Tim
12
Hui, Wang
8
Clark, Ian
8
Koshy, P J T
8
Milner, Jennifer
8
Young, David
5
Shingleton, WD
5
Richards, Carl
5
Jones, Debra
4
Life, PF
4
Catterall, Jon
4
Edwards, Dylan
4
Peake, NJ
3
Wait, Robin
3
Foster, Helen

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Publications

TOP 3
Lakey Rachel L; Morgan Tanya G; Rowan Andrew D; Isaacs John D; Cawston Tim E; Hilkens Catharien M U
A novel paradigm for dendritic cells as effectors of cartilage destruction.
Milner J M; Patel A; Rowan A D
Emerging roles of serine proteinases in tissue turnover in arthritis.
Zhang Q; Hui W; Litherland G J; Barter M J; Davidson R; Darrah C; Donell S T; Clark I M; Cawston T E; Robinson J H; Rowan A D; Young D A
Differential Toll-like receptor-dependent collagenase expression in chondrocytes.

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All Publications

2009: Lakey Rachel L; Morgan Tanya G; Rowan Andrew D; Isaacs John D; Cawston Tim E; Hilkens Catharien M U
A novel paradigm for dendritic cells as effectors of cartilage destruction.
Rheumatology (Oxford, England) 2009;48(5):502-7.
2008: Milner J M; Patel A; Rowan A D
Emerging roles of serine proteinases in tissue turnover in arthritis.
Arthritis and rheumatism 2008;58(12):3644-56.
2008: Zhang Q; Hui W; Litherland G J; Barter M J; Davidson R; Darrah C; Donell S T; Clark I M; Cawston T E; Robinson J H; Rowan A D; Young D A
Differential Toll-like receptor-dependent collagenase expression in chondrocytes.
Annals of the rheumatic diseases 2008;67(11):1633-41.
2008: Litherland Gary J; Dixon Craig; Lakey Rachel L; Robson Timothy; Jones Debra; Young David A; Cawston Tim E; Rowan Andrew D
Synergistic collagenase expression and cartilage collagenolysis are phosphatidylinositol 3-kinase/Akt signaling-dependent.
The Journal of biological chemistry 2008;283(21):14221-9.
2008: Rowan Andrew D; Litherland Gary J; Hui Wang; Milner Jennifer M
Metalloproteases as potential therapeutic targets in arthritis treatment.
Expert opinion on therapeutic targets 2008;12(1):1-18.
2007: Bigg Heather F; Rowan Andrew D; Barker Michael D; Cawston Tim E
Activity of matrix metalloproteinase-9 against native collagen types I and III.
The FEBS journal 2007;274(5):1246-55.
2007: Rowan Andrew D; Young David A
Collagenase gene regulation by pro-inflammatory cytokines in cartilage.
Frontiers in bioscience : a journal and virtual library 2007;12():536-50.
2006: Peake N J; Khawaja K; Myers A; Nowell M A; Jones S A; Rowan A D; Cawston T E; Foster H E
Interleukin-6 signalling in juvenile idiopathic arthritis is limited by proteolytically cleaved soluble interleukin-6 receptor.
Rheumatology (Oxford, England) 2006;45(12):1485-9.
2006: Barksby H E; Milner J M; Patterson A M; Peake N J; Hui W; Robson T; Lakey R; Middleton J; Cawston T E; Richards C D; Rowan A D
Matrix metalloproteinase 10 promotion of collagenolysis via procollagenase activation: implications for cartilage degradation in arthritis.
Arthritis and rheumatism 2006;54(10):3244-53.
2006: Catterall J B; Rowan A D; Sarsfield S; Saklatvala J; Wait R; Cawston T E
Development of a novel 2D proteomics approach for the identification of proteins secreted by primary chondrocytes after stimulation by IL-1 and oncostatin M.
Rheumatology (Oxford, England) 2006;45(9):1101-9.
2006: Shingleton W D; Jones D; Xu X; Cawston T E; Rowan A D
Retinoic acid and oncostatin M combine to promote cartilage degradation via matrix metalloproteinase-13 expression in bovine but not human chondrocytes.
Rheumatology (Oxford, England) 2006;45(8):958-65.
2006: Bigg Heather F; Wait Robin; Rowan Andrew D; Cawston Tim E
The mammalian chitinase-like lectin, YKL-40, binds specifically to type I collagen and modulates the rate of type I collagen fibril formation.
The Journal of biological chemistry 2006;281(30):21082-95.
2006: Peake N J; Foster H E; Khawaja K; Cawston T E; Rowan A D
Assessment of the clinical significance of gelatinase activity in patients with juvenile idiopathic arthritis using quantitative protein substrate zymography.
Annals of the rheumatic diseases 2006;65(4):501-7.
2006: Barksby H E; Hui W; Wappler I; Peters H H; Milner J M; Richards C D; Cawston T E; Rowan A D
Interleukin-1 in combination with oncostatin M up-regulates multiple genes in chondrocytes: implications for cartilage destruction and repair.
Arthritis and rheumatism 2006;54(2):540-50.
2006: Morgan T G; Rowan A D; Dickinson S C; Jones D; Hollander A P; Deehan D; Cawston T E
Human nasal cartilage responds to oncostatin M in combination with interleukin 1 or tumour necrosis factor alpha by the release of collagen fragments via collagenases.
Annals of the rheumatic diseases 2006;65(2):184-90.
2006: Milner Jennifer M; Rowan Andrew D; Cawston Tim E; Young David A
Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis.
Arthritis research & therapy 2006;8(5):R142.
2006: Milner Jennifer M; Kevorkian Lara; Young David A; Jones Debra; Wait Robin; Donell Simon T; Barksby Emma; Patterson Angela M; Middleton Jim; Cravatt Benjamin F; Clark Ian M; Rowan Andrew D; Cawston Timothy E
Fibroblast activation protein alpha is expressed by chondrocytes following a pro-inflammatory stimulus and is elevated in osteoarthritis.
Arthritis research & therapy 2006;8(1):R23.
2005: Peake N J; Khawaja K; Myers A; Jones D; Cawston T E; Rowan A D; Foster H E
Levels of matrix metalloproteinase (MMP)-1 in paired sera and synovial fluids of juvenile idiopathic arthritis patients: relationship to inflammatory activity, MMP-3 and tissue inhibitor of metalloproteinases-1 in a longitudinal study.
Rheumatology (Oxford, England) 2005;44(11):1383-9.
2005: Hui W; Barksby H E; Young D A; Cawston T E; McKie N; Rowan A D
Oncostatin M in combination with tumour necrosis factor {alpha} induces a chondrocyte membrane associated aggrecanase that is distinct from ADAMTS aggrecanase-1 or -2.
Annals of the rheumatic diseases 2005;64(11):1624-32.
2005: Hui Wang; Cawston Tim E; Richards Carl D; Rowan Andrew D
A model of inflammatory arthritis highlights a role for oncostatin M in pro-inflammatory cytokine-induced bone destruction via RANK/RANKL.
Arthritis research & therapy 2005;7(1):R57-64.
2003: Hui W; Rowan A D; Richards C D; Cawston T E
Oncostatin M in combination with tumor necrosis factor alpha induces cartilage damage and matrix metalloproteinase expression in vitro and in vivo.
Arthritis and rheumatism 2003;48(12):3404-18.
2003: Rowan Andrew D; Hui Wang; Cawston Tim E; Richards Carl D
Adenoviral gene transfer of interleukin-1 in combination with oncostatin M induces significant joint damage in a murine model.
The American journal of pathology 2003;162(6):1975-84.
2003: Milner J M; Rowan A D; Elliott S-F; Cawston T E
Inhibition of furin-like enzymes blocks interleukin-1alpha/oncostatin M-stimulated cartilage degradation.
Arthritis and rheumatism 2003;48(4):1057-66.
2003: Hall Marie-Claire; Young David A; Waters Jasmine G; Rowan Andrew D; Chantry Andrew; Edwards Dylan R; Clark Ian M
The comparative role of activator protein 1 and Smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-beta 1.
The Journal of biological chemistry 2003;278(12):10304-13.
2003: Hui W; Cawston T; Rowan A D
Transforming growth factor beta 1 and insulin-like growth factor 1 block collagen degradation induced by oncostatin M in combination with tumour necrosis factor alpha from bovine cartilage.
Annals of the rheumatic diseases 2003;62(2):172-4.
2003: Cawston Tim E; Milner Jenny M; Catterall Jon B; Rowan Andrew D
Cytokine synergy, collagenases and cartilage collagen breakdown.
Biochemical Society symposium 2003;(70):125-33.
2002: Hall M-C; Young D A; Rowan A D; Edwards D R; Clark I M
Cryptic promoter activity of pBLCAT3 induced by overexpression of AP1 factors.
BioTechniques 2002;33(5):1004, 1006, 1008.
2002: Koshy P J; Henderson N; Logan C; Life P F; Cawston T E; Rowan A D
Interleukin 17 induces cartilage collagen breakdown: novel synergistic effects in combination with proinflammatory cytokines.
Annals of the rheumatic diseases 2002;61(8):704-13.
2002: Koshy P J T; Lundy C J; Rowan A D; Porter S; Edwards D R; Hogan A; Clark I M; Cawston T E
The modulation of matrix metalloproteinase and ADAM gene expression in human chondrocytes by interleukin-1 and oncostatin M: a time-course study using real-time quantitative reverse transcription-polymerase chain reaction.
Arthritis and rheumatism 2002;46(4):961-7.
2002: Vaidya B; Pearce S H S; Charlton S; Marshall N; Rowan A D; Griffiths I D; Kendall-Taylor P; Cawston T E; Young-Min S
An association between the CTLA4 exon 1 polymorphism and early rheumatoid arthritis with autoimmune endocrinopathies.
Rheumatology (Oxford, England) 2002;41(2):180-3.
2001: Hui W; Rowan A D; Cawston T
Modulation of the expression of matrix metalloproteinase and tissue inhibitors of metalloproteinases by TGF-beta1 and IGF-1 in primary human articular and bovine nasal chondrocytes stimulated with TNF-alpha.
Cytokine 2001;16(1):31-5.
2001: Catterall J B; Carrère S; Koshy P J; Degnan B A; Shingleton W D; Brinckerhoff C E; Rutter J; Cawston T E; Rowan A D
Synergistic induction of matrix metalloproteinase 1 by interleukin-1alpha and oncostatin M in human chondrocytes involves signal transducer and activator of transcription and activator protein 1 transcription factors via a novel mechanism.
Arthritis and rheumatism 2001;44(10):2296-310.
2001: Rowan A D; Koshy P J; Shingleton W D; Degnan B A; Heath J K; Vernallis A B; Spaull J R; Life P F; Hudson K; Cawston T E
Synergistic effects of glycoprotein 130 binding cytokines in combination with interleukin-1 on cartilage collagen breakdown.
Arthritis and rheumatism 2001;44(7):1620-32.
2001: Bigg H F; Rowan A D
The inhibition of metalloproteinases as a therapeutic target in rheumatoid arthritis and osteoarthritis.
Current opinion in pharmacology 2001;1(3):314-20.
2001: Hui W; Rowan A D; Cawston T
Insulin-like growth factor 1 blocks collagen release and down regulates matrix metalloproteinase-1, -3, -8, and -13 mRNA expression in bovine nasal cartilage stimulated with oncostatin M in combination with interleukin 1alpha.
Annals of the rheumatic diseases 2001;60(3):254-61.
2001: Elliott S; Rowan A D; Carrère S; Koshy P; Catterall J B; Cawston T E
Esculetin inhibits cartilage resorption induced by interleukin 1alpha in combination with oncostatin M.
Annals of the rheumatic diseases 2001;60(2):158-65.
2001: Cleaver C S; Rowan A D; Cawston T E
Interleukin 13 blocks the release of collagen from bovine nasal cartilage treated with proinflammatory cytokines.
Annals of the rheumatic diseases 2001;60(2):150-7.
2001: Cawston T E; Koshy P; Rowan A D
Assay of matrix metalloproteinases against matrix substrates.
Methods in molecular biology (Clifton, N.J.) 2001;151():389-97.
2000: Shingleton W D; Ellis A J; Rowan A D; Cawston T E
Retinoic acid combines with interleukin-1 to promote the degradation of collagen from bovine nasal cartilage: matrix metalloproteinases-1 and -13 are involved in cartilage collagen breakdown.
Journal of cellular biochemistry 2000;79(4):519-31.
2000: Hui W; Rowan A D; Cawston T
Transforming growth factor beta1 blocks the release of collagen fragments from boving nasal cartilage stimulated by oncostatin M in combination with IL-1alpha.
Cytokine 2000;12(6):765-9.
1999: Koshy P J; Rowan A D; Life P F; Cawston T E
96-Well plate assays for measuring collagenase activity using (3)H-acetylated collagen.
Analytical biochemistry 1999;275(2):202-7.
1998: Hodges D J; Reid D G; Rowan A D; Clark I M; Cawston T E
Preparation of recombinant tissue inhibitor of metalloproteinases-1 (TIMP-1) in high yield and identification of a hydrophobic surface feature.
European journal of biochemistry / FEBS 1998;257(3):562-9.
1998: Cawston T E; Curry V A; Summers C A; Clark I M; Riley G P; Life P F; Spaull J R; Goldring M B; Koshy P J; Rowan A D; Shingleton W D
The role of oncostatin M in animal and human connective tissue collagen turnover and its localization within the rheumatoid joint.
Arthritis and rheumatism 1998;41(10):1760-71.
1997: Clark I M; Rowan A D; Edwards D R; Bech-Hansen T; Mann D A; Bahr M J; Cawston T E
Transcriptional activity of the human tissue inhibitor of metalloproteinases 1 (TIMP-1) gene in fibroblasts involves elements in the promoter, exon 1 and intron 1.
The Biochemical journal 1997;324 ( Pt 2)():611-7.

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