Timothy Billiar

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Sengupta Rajib; Billiar Timothy R; Atkins James L; Kagan Valerian E; Stoyanovsky Detcho A
Nitric oxide and dihydrolipoic acid modulate the activity of caspase 3 in HepG2 cells.
Neal Matthew D; Cushieri Joseph; Rosengart Matthew R; Alarcon Louis H; Moore Ernest E; Maier Ronald V; Minei Joseph P; Billiar Timothy R; Peitzman Andrew B; Sperry Jason L;
Preinjury statin use is associated with a higher risk of multiple organ failure after injury: a propensity score adjusted analysis.
Pan Pinhua; Cardinal Jon; Dhupar Rajeev; Rosengart Matthew R; Lotze Michael T; Geller David A; Billiar Timothy R; Tsung Allan
Low-dose cisplatin administration in murine cecal ligation and puncture prevents the systemic release of HMGB1 and attenuates lethality.

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All Publications

2009: Sengupta Rajib; Billiar Timothy R; Atkins James L; Kagan Valerian E; Stoyanovsky Detcho A
Nitric oxide and dihydrolipoic acid modulate the activity of caspase 3 in HepG2 cells.
FEBS letters 2009;583(21):3525-30.
2009: Neal Matthew D; Cushieri Joseph; Rosengart Matthew R; Alarcon Louis H; Moore Ernest E; Maier Ronald V; Minei Joseph P; Billiar Timothy R; Peitzman Andrew B; Sperry Jason L;
Preinjury statin use is associated with a higher risk of multiple organ failure after injury: a propensity score adjusted analysis.
The Journal of trauma 2009;67(3):476-82; discussion 482-4.
2009: Pan Pinhua; Cardinal Jon; Dhupar Rajeev; Rosengart Matthew R; Lotze Michael T; Geller David A; Billiar Timothy R; Tsung Allan
Low-dose cisplatin administration in murine cecal ligation and puncture prevents the systemic release of HMGB1 and attenuates lethality.
Journal of leukocyte biology 2009;86(3):625-32.
2009: Watson Gregory A; Sperry Jason L; Rosengart Matthew R; Minei Joseph P; Harbrecht Brian G; Moore Ernest E; Cuschieri Joseph; Maier Ronald V; Billiar Timothy R; Peitzman Andrew B;
Fresh frozen plasma is independently associated with a higher risk of multiple organ failure and acute respiratory distress syndrome.
The Journal of trauma 2009;67(2):221-7; discussion 228-30.
2009: Zhan Jianghua; Nakao Atsunori; Sugimoto Ryujiro; Dhupar Rajeev; Wang Yinna; Wang Zhiliang; Billiar Timothy R; McCurry Kenneth R
Orally administered nitrite attenuates cardiac allograft rejection in rats.
Surgery 2009;146(2):155-65.
2009: Cao Zongxian; Yuan Youzhong; Jeyabalan Geetha; Du Qiang; Tsung Allan; Geller David A; Billiar Timothy R
Preactivation of NKT cells with alpha-GalCer protects against hepatic ischemia-reperfusion injury in mouse by a mechanism involving IL-13 and adenosine A2A receptor.
American journal of physiology. Gastrointestinal and liver physiology 2009;297(2):G249-58.
2009: Metukuri Mallikarjuna Reddy; Namas Rajaie; Gladstone Chase; Clermont Thierry; Jefferson Bahiyya; Barclay Derek; Hermus Linda; Billiar Timothy R; Zamora Ruben; Vodovotz Yoram
Activation of latent transforming growth factor-beta1 by nitric oxide in macrophages: role of soluble guanylate cyclase and MAP kinases.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2009;17(4):578-88.
2009: Kaczorowski David J; Nakao Atsunori; Vallabhaneni Raghuveer; Mollen Kevin P; Sugimoto Ryujiro; Kohmoto Junichi; Zuckerbraun Brian S; McCurry Kenneth R; Billiar Timothy R
Mechanisms of Toll-like receptor 4 (TLR4)-mediated inflammation after cold ischemia/reperfusion in the heart.
Transplantation 2009;87(10):1455-63.
2009: Scott Melanie J; Liu Shubing; Shapiro Richard A; Vodovotz Yoram; Billiar Timothy R
Endotoxin uptake in mouse liver is blocked by endotoxin pretreatment through a suppressor of cytokine signaling-1-dependent mechanism.
Hepatology (Baltimore, Md.) 2009;49(5):1695-708.
2009: Metukuri Mallikarjuna R; Beer-Stolz Donna; Namas Rajaie A; Dhupar Rajeev; Torres Andres; Loughran Patricia A; Jefferson Bahiyyah S; Tsung Allan; Billiar Timothy R; Vodovotz Yoram; Zamora Ruben
Expression and subcellular localization of BNIP3 in hypoxic hepatocytes and liver stress.
American journal of physiology. Gastrointestinal and liver physiology 2009;296(3):G499-509.
2009: Nakao Atsunori; Sugimoto Ryujiro; Billiar Timothy R; McCurry Kenneth R
Therapeutic antioxidant medical gas.
Journal of clinical biochemistry and nutrition 2009;44(1):1-13.
2009: Sengupta Rajib; Billiar Timothy R; Stoyanovsky Detcho A
Studies toward the analysis of S-nitrosoproteins.
Organic & biomolecular chemistry 2009;7(2):232-4.
2009: Liu Yujian; Yuan Youzhong; Li Yuehua; Zhang Jian; Xiao Guozhi; Vodovotz Yoram; Billiar Timothy R; Wilson Mark A; Fan Jie
Interacting neuroendocrine and innate and acquired immune pathways regulate neutrophil mobilization from bone marrow following hemorrhagic shock.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(1):572-80.
2009: Kaczorowski David J; Tsung Allan; Billiar Timothy R
Innate immune mechanisms in ischemia/reperfusion.
Frontiers in bioscience (elite edition) 2009;1():91-8.
2009: Jeong Moonsup; Kwon Yong-Sam; Park Soon-Hye; Kim Chae-Young; Jeun Sin-Soo; Song Kang-Won; Ko Yong; Robbins Paul D; Billiar Timothy R; Kim Byong-Moon; Seol Dai-Wu
Possible novel therapy for malignant gliomas with secretable trimeric TRAIL.
PloS one 2009;4(2):e4545.
2008: Kobbe Philipp; Kaczorowski David J; Vodovotz Yoram; Tzioupis Christopher H; Mollen Kevin P; Billiar Timothy R; Pape Hans-Christoph
Local exposure of bone components to injured soft tissue induces Toll-like receptor 4-dependent systemic inflammation with acute lung injury.
Shock (Augusta, Ga.) 2008;30(6):686-91.
2008: Sperry Jason L; Ochoa Juan B; Gunn Scott R; Alarcon Louis H; Minei Joseph P; Cuschieri Joseph; Rosengart Matthew R; Maier Ronald V; Billiar Timothy R; Peitzman Andrew B; Moore Ernest E;
An FFP:PRBC transfusion ratio >/=1:1.5 is associated with a lower risk of mortality after massive transfusion.
The Journal of trauma 2008;65(5):986-93.
2008: Aneja Rajesh K; Tsung Allan; Sjodin Hanna; Gefter Julia V; Delude Russell L; Billiar Timothy R; Fink Mitchell P
Preconditioning with high mobility group box 1 (HMGB1) induces lipopolysaccharide (LPS) tolerance.
Journal of leukocyte biology 2008;84(5):1326-34.
2008: Zhang Xianghong; Wheeler David; Tang Ying; Guo Lanping; Shapiro Richard A; Ribar Thomas J; Means Anthony R; Billiar Timothy R; Angus Derek C; Rosengart Matthew R
Calcium/calmodulin-dependent protein kinase (CaMK) IV mediates nucleocytoplasmic shuttling and release of HMGB1 during lipopolysaccharide stimulation of macrophages.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(7):5015-23.
2008: Buchholz B M; Kaczorowski D J; Sugimoto R; Yang R; Wang Y; Billiar T R; McCurry K R; Bauer A J; Nakao A
Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2008;8(10):2015-24.
2008: Scott Melanie J; Billiar Timothy R
Beta2-integrin-induced p38 MAPK activation is a key mediator in the CD14/TLR4/MD2-dependent uptake of lipopolysaccharide by hepatocytes.
The Journal of biological chemistry 2008;283(43):29433-46.
2008: Zhang Xiaoying; Vallabhaneni Raghuveer; Loughran Patricia A; Shapiro Richard; Yin Xiao-Min; Yuan Youzhong; Billiar Timothy R
Changes in FADD levels, distribution, and phosphorylation in TNFalpha-induced apoptosis in hepatocytes is caspase-3, caspase-8 and BID dependent.
Apoptosis : an international journal on programmed cell death 2008;13(8):983-92.
2008: Kobbe Philipp; Vodovotz Yoram; Kaczorowski David J; Billiar Timothy R; Pape Hans-Christoph
The role of fracture-associated soft tissue injury in the induction of systemic inflammation and remote organ dysfunction after bilateral femur fracture.
Journal of orthopaedic trauma 2008;22(6):385-90.
2008: Kobbe Philipp; Vodovotz Yoram; Kaczorowski David J; Mollen Kevin P; Billiar Timothy R; Pape Hans-Christoph
Patterns of cytokine release and evolution of remote organ dysfunction after bilateral femur fracture.
Shock (Augusta, Ga.) 2008;30(1):43-7.
2008: Kim Hoe Suk; Loughran Patricia A; Rao Jayashree; Billiar Timothy R; Zuckerbraun Brian S
Carbon monoxide activates NF-kappaB via ROS generation and Akt pathways to protect against cell death of hepatocytes.
American journal of physiology. Gastrointestinal and liver physiology 2008;295(1):G146-G152.
2008: Klune John R; Dhupar Rajeev; Cardinal Jon; Billiar Timothy R; Tsung Allan
HMGB1: endogenous danger signaling.
Molecular medicine (Cambridge, Mass.) 2008;14(7-8):476-84.
2008: Kim Hoe Suk; Loughran Patricia A; Billiar Timothy R
Carbon monoxide decreases the level of iNOS protein and active dimer in IL-1beta-stimulated hepatocytes.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2008;18(4):256-65.
2008: Nakao Atsunori; Kaczorowski David J; Sugimoto Ryujiro; Billiar Timothy R; McCurry Kenneth R
Application of heme oxygenase-1, carbon monoxide and biliverdin for the prevention of intestinal ischemia/reperfusion injury.
Journal of clinical biochemistry and nutrition 2008;42(2):78-88.
2008: Sperry Jason L; Friese Randall S; Frankel Heidi L; West Micheal A; Cuschieri Joseph; Moore Ernest E; Harbrecht Brian G; Peitzman Andrew B; Billiar Timothy R; Maier Ronald V; Remick Daniel G; Minei Joseph P;
Male gender is associated with excessive IL-6 expression following severe injury.
The Journal of trauma 2008;64(3):572-8; discussion 578-9.
2008: Nakao Atsunori; Kaczorowski David J; Zuckerbraun Brian S; Lei Jing; Faleo Gaetano; Deguchi Kentaro; McCurry Kenneth R; Billiar Timothy R; Kanno Shinichi
Galantamine and carbon monoxide protect brain microvascular endothelial cells by heme oxygenase-1 induction.
Biochemical and biophysical research communications 2008;367(3):674-9.
2008: Kaczorowski David J; Mollen Kevin P; Edmonds Rebecca; Billiar Timothy R
Early events in the recognition of danger signals after tissue injury.
Journal of leukocyte biology 2008;83(3):546-52.
2008: Klune J R; Billiar T R; Tsung A
HMGB1 preconditioning: therapeutic application for a danger signal?
Journal of leukocyte biology 2008;83(3):558-63.
2008: Kim Young-Myeong; Choi Byung-Min; Kim Yong-Seok; Kwon Young-Guen; Kibbe Melina R; Billiar Timothy R; Tzeng Edith
Protective effect of p53 in vascular smooth muscle cells against nitric oxide-induced apoptosis is mediated by up-regulation of heme oxygenase-2.
BMB reports 2008;41(2):164-9.
2008: Zhang Qiuhong; He Fengtian; Kuruba Ramalinga; Gao Xiang; Wilson Annette; Li Jiang; Billiar Timothy R; Pitt Bruce R; Xie Wen; Li Song
FXR-mediated regulation of angiotensin type 2 receptor expression in vascular smooth muscle cells.
Cardiovascular research 2008;77(3):560-9.
2008: Mollen Kevin P; Levy Ryan M; Prince Jose M; Hoffman Rosemary A; Scott Melanie J; Kaczorowski David J; Vallabhaneni Raghuveer; Vodovotz Yoram; Billiar Timothy R
Systemic inflammation and end organ damage following trauma involves functional TLR4 signaling in both bone marrow-derived cells and parenchymal cells.
Journal of leukocyte biology 2008;83(1):80-8.
2008: Forsythe Raquel M; Wessel Charles B; Billiar Timothy R; Angus Derek C; Rosengart Matthew R
Parenteral calcium for intensive care unit patients.
Cochrane database of systematic reviews (Online) 2008;(4):CD006163.
2008: Na Hee-Jun; Chung Hun-Taeg; Ha Kwon-Soo; Lee Hansoo; Kwon Young-Guen; Billiar Timothy R; Kim Young-Myeong
Detection and measurement for the modification and inactivation of caspase by nitrosative stress in vitro and in vivo.
Methods in enzymology 2008;441():317-27.
2008: Bagci Elife Z; Vodovotz Yoram; Billiar Timothy R; Ermentrout Bard; Bahar Ivet
Computational insights on the competing effects of nitric oxide in regulating apoptosis.
PloS one 2008;3(5):e2249.
2007: Lotze Michael T; Zeh Herbert J; Rubartelli Anna; Sparvero Louis J; Amoscato Andrew A; Washburn Newell R; Devera Michael E; Liang Xiaoyan; Tör Mahmut; Billiar Timothy
The grateful dead: damage-associated molecular pattern molecules and reduction/oxidation regulate immunity.
Immunological reviews 2007;220():60-81.
2007: Kaczorowski David J; Nakao Atsunori; Mollen Kevin P; Vallabhaneni Raghuveer; Sugimoto Ryujiro; Kohmoto Junichi; Tobita Kimimasa; Zuckerbraun Brian S; McCurry Kenneth R; Murase Noriko; Billiar Timothy R
Toll-like receptor 4 mediates the early inflammatory response after cold ischemia/reperfusion.
Transplantation 2007;84(10):1279-87.
2007: Tsung Allan; Klune John R; Zhang Xianghong; Jeyabalan Geetha; Cao Zongxian; Peng Ximei; Stolz Donna B; Geller David A; Rosengart Matthew R; Billiar Timothy R
HMGB1 release induced by liver ischemia involves Toll-like receptor 4 dependent reactive oxygen species production and calcium-mediated signaling.
The Journal of experimental medicine 2007;204(12):2913-23.
2007: Kohmoto J; Nakao A; Stolz D B; Kaizu T; Tsung A; Ikeda A; Shimizu H; Takahashi T; Tomiyama K; Sugimoto R; Choi A M K; Billiar T R; Murase N; McCurry K R
Carbon monoxide protects rat lung transplants from ischemia-reperfusion injury via a mechanism involving p38 MAPK pathway.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007;7(10):2279-90.
2007: Levy Ryan M; Mollen Kevin P; Prince Jose M; Kaczorowski David J; Vallabhaneni Raghuveer; Liu Shiguang; Tracey Kevin J; Lotze Michael T; Hackam David J; Fink Mitchell P; Vodovotz Yoram; Billiar Timothy R
Systemic inflammation and remote organ injury following trauma require HMGB1.
American journal of physiology. Regulatory, integrative and comparative physiology 2007;293(4):R1538-44.
2007: Prince Jose M; Vallabhaneni Raghuveer; Zenati Mazen S; Hughes Steven J; Harbrecht Brian G; Lee Kenneth K; Watson Andrew R; Peitzman Andrew B; Billiar Timothy R; Brown Matthew T
Increased interactive format for Morbidity & Mortality conference improves educational value and enhances confidence.
Journal of surgical education 2007;64(5):266-72.
2007: Mollen Kevin P; McCloskey Carol A; Tanaka Hiroyuki; Prince Jose M; Levy Ryan M; Zuckerbraun Brian S; Billiar Timothy R
Hypoxia activates c-Jun N-terminal kinase via Rac1-dependent reactive oxygen species production in hepatocytes.
Shock (Augusta, Ga.) 2007;28(3):270-7.
2007: Fan Jie; Li Yuehua; Vodovotz Yoram; Billiar Timothy R; Wilson Mark A
Neutrophil NAD(P)H oxidase is required for hemorrhagic shock-enhanced TLR2 up-regulation in alveolar macrophages in response to LPS.
Shock (Augusta, Ga.) 2007;28(2):213-8.
2007: Sengupta Rajib; Ryter Stefan W; Zuckerbraun Brian S; Tzeng Edith; Billiar Timothy R; Stoyanovsky Detcho A
Thioredoxin catalyzes the denitrosation of low-molecular mass and protein S-nitrosothiols.
Biochemistry 2007;46(28):8472-83.
2007: Ellerman Jessica E; Brown Charles K; de Vera Michael; Zeh Herbert J; Billiar Timothy; Rubartelli Anna; Lotze Michael T
Masquerader: high mobility group box-1 and cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(10):2836-48.
2007: Fan Jie; Li Yuehua; Levy Ryan M; Fan Janet J; Hackam David J; Vodovotz Yoram; Yang Huan; Tracey Kevin J; Billiar Timothy R; Wilson Mark A
Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: role of HMGB1-TLR4 signaling.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(10):6573-80.
2007: Tsung Allan; McCoy Sharon L; Klune John R; Geller David A; Billiar Timothy R; Hefeneider Steven H
A novel inhibitory peptide of Toll-like receptor signaling limits lipopolysaccharide-induced production of inflammatory mediators and enhances survival in mice.
Shock (Augusta, Ga.) 2007;27(4):364-9.
2007: Bayir Hülya; Kagan Valerian E; Clark Robert S B; Janesko-Feldman Keri; Rafikov Ruslan; Huang Zhentai; Zhang Xiaojing; Vagni Vincent; Billiar Timothy R; Kochanek Patrick M
Neuronal NOS-mediated nitration and inactivation of manganese superoxide dismutase in brain after experimental and human brain injury.
Journal of neurochemistry 2007;101(1):168-81.
2007: Zuckerbraun Brian S; Chin Beek Yoke; Bilban Martin; d'Avila Joana de Costa; Rao Jayashree; Billiar Timothy R; Otterbein Leo E
Carbon monoxide signals via inhibition of cytochrome c oxidase and generation of mitochondrial reactive oxygen species.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007;21(4):1099-106.
2007: Kaczorowski David J; Billiar Timothy R
Targeting CD47: NO limit on therapeutic potential.
Circulation research 2007;100(5):602-3.
2007: Billiar Timothy R
Making progress in an enlightened era: opportunities and obstacles.
Surgical infections 2007;8(1):5-14.
2007: Prince Jose M; Ming Mei Jian; Levy Ryan M; Liu Shubing; Pinsky David J; Vodovotz Yoram; Billiar Timothy R
Early growth response 1 mediates the systemic and hepatic inflammatory response initiated by hemorrhagic shock.
Shock (Augusta, Ga.) 2007;27(2):157-64.
2007: Tsung Allan; Zheng Ning; Jeyabalan Geetha; Izuishi Kunihiko; Klune John R; Geller David A; Lotze Michael T; Lu Lina; Billiar Timothy R
Increasing numbers of hepatic dendritic cells promote HMGB1-mediated ischemia-reperfusion injury.
Journal of leukocyte biology 2007;81(1):119-28.
2006: Lagoa Claudio E; Bartels John; Baratt Arie; Tseng George; Clermont Gilles; Fink Mitchell P; Billiar Timothy R; Vodovotz Yoram
The role of initial trauma in the host's response to injury and hemorrhage: insights from a correlation of mathematical simulations and hepatic transcriptomic analysis.
Shock (Augusta, Ga.) 2006;26(6):592-600.
2006: Jeyabalan G; Tsung A; Billiar T R
Linking proximal and downstream signalling events in hepatic ischaemia/reperfusion injury.
Biochemical Society transactions 2006;34(Pt 5):957-9.
2006: Mollen Kevin P; Anand Rahul J; Tsung Allan; Prince Jose M; Levy Ryan M; Billiar Timothy R
Emerging paradigm: toll-like receptor 4-sentinel for the detection of tissue damage.
Shock (Augusta, Ga.) 2006;26(5):430-7.
2006: Raman Kathleen G; Sappington Penny L; Yang Runkuan; Levy Ryan M; Prince Jose M; Liu Shiguang; Watkins Simon K; Schmidt Ann Marie; Billiar Timothy R; Fink Mitchell P
The role of RAGE in the pathogenesis of intestinal barrier dysfunction after hemorrhagic shock.
American journal of physiology. Gastrointestinal and liver physiology 2006;291(4):G556-65.
2006: Levy Ryan M; Prince Jose M; Yang Runkuan; Mollen Kevin P; Liao Hong; Watson Gregory A; Fink Mitchell P; Vodovotz Yoram; Billiar Timothy R
Systemic inflammation and remote organ damage following bilateral femur fracture requires Toll-like receptor 4.
American journal of physiology. Regulatory, integrative and comparative physiology 2006;291(4):R970-6.
2006: Izuishi Kunihiko; Tsung Allan; Hossain Mohammad Akram; Fujiwara Masao; Wakabayashi Hisao; Masaki Tsutomu; Billiar Timothy R; Maeta Hajime
Ischemic preconditioning of the murine liver protects through the Akt kinase pathway.
Hepatology (Baltimore, Md.) 2006;44(3):573-80.
2006: Vodovotz Yoram; Chow Carson C; Bartels John; Lagoa Claudio; Prince Jose M; Levy Ryan M; Kumar Rukmini; Day Judy; Rubin Jonathan; Constantine Greg; Billiar Timothy R; Fink Mitchell P; Clermont Gilles
In silico models of acute inflammation in animals.
Shock (Augusta, Ga.) 2006;26(3):235-44.
2006: Zuckerbraun Brian S; Chin Beek Yoke; Wegiel Barbara; Billiar Timothy R; Czsimadia Eva; Rao Jayashree; Shimoda Larissa; Ifedigbo Emeka; Kanno Shin; Otterbein Leo E
Carbon monoxide reverses established pulmonary hypertension.
The Journal of experimental medicine 2006;203(9):2109-19.
2006: Kohmoto Junichi; Nakao Atsunori; Kaizu Takashi; Tsung Allan; Ikeda Atsushi; Tomiyama Koji; Billiar Timothy R; Choi Augustine M K; Murase Noriko; McCurry Kenneth R
Low-dose carbon monoxide inhalation prevents ischemia/reperfusion injury of transplanted rat lung grafts.
Surgery 2006;140(2):179-85.
2006: Türler Andreas; Kalff Jörg C; Moore Beverley A; Hoffman Rosemary A; Billiar Timothy R; Simmons Richard L; Bauer Anthony J
Leukocyte-derived inducible nitric oxide synthase mediates murine postoperative ileus.
Annals of surgery 2006;244(2):220-9.
2006: Izuishi Kunihiko; Tsung Allan; Jeyabalan Geetha; Critchlow Nathan D; Li Jianhua; Tracey Kevin J; Demarco Richard A; Lotze Michael T; Fink Mitchell P; Geller David A; Billiar Timothy R
Cutting edge: high-mobility group box 1 preconditioning protects against liver ischemia-reperfusion injury.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(12):7154-8.
2006: Kim Hoe Suk; Loughran Patricia A; Kim Peter K; Billiar Timothy R; Zuckerbraun Brian S
Carbon monoxide protects hepatocytes from TNF-alpha/Actinomycin D by inhibition of the caspase-8-mediated apoptotic pathway.
Biochemical and biophysical research communications 2006;344(4):1172-8.
2006: Prince Jose M; Levy Ryan M; Bartels John; Baratt Arie; Kane John M; Lagoa Claudio; Rubin Jonathan; Day Judy; Wei Joyce; Fink Mitchell P; Goyert Sanna M; Clermont Gilles; Billiar Timothy R; Vodovotz Yoram
In silico and in vivo approach to elucidate the inflammatory complexity of CD14-deficient mice.
Molecular medicine (Cambridge, Mass.) 2006;12(4-6):88-96.
2006: Yang Runkuan; Harada Tomoyuki; Mollen Kevin P; Prince Jose M; Levy Ryan M; Englert Joshua A; Gallowitsch-Puerta Margot; Yang LiHong; Yang Huan; Tracey Kevin J; Harbrecht Brian G; Billiar Timothy R; Fink Mitchell P
Anti-HMGB1 neutralizing antibody ameliorates gut barrier dysfunction and improves survival after hemorrhagic shock.
Molecular medicine (Cambridge, Mass.) 2006;12(4-6):105-14.
2006: Fan Jie; Li Yuehua; Vodovotz Yoram; Billiar Timothy R; Wilson Mark A
Hemorrhagic shock-activated neutrophils augment TLR4 signaling-induced TLR2 upregulation in alveolar macrophages: role in hemorrhage-primed lung inflammation.
American journal of physiology. Lung cellular and molecular physiology 2006;290(4):L738-L746.
2006: Wang Y; Kim Peter K M; Peng X; Loughran P; Vodovotz Y; Zhang B; Billiar T R
Cyclic AMP and cyclic GMP suppress TNFalpha-induced hepatocyte apoptosis by inhibiting FADD up-regulation via a protein kinase A-dependent pathway.
Apoptosis : an international journal on programmed cell death 2006;11(3):441-51.
2006: Prince Jose M; Levy Ryan M; Yang Runkuan; Mollen Kevin P; Fink Mitchell P; Vodovotz Yoram; Billiar Timothy R
Toll-like receptor-4 signaling mediates hepatic injury and systemic inflammation in hemorrhagic shock.
Journal of the American College of Surgeons 2006;202(3):407-17.
2006: Neal Matthew D; Leaphart Cynthia; Levy Ryan; Prince Jose; Billiar Timothy R; Watkins Simon; Li Jun; Cetin Selma; Ford Henri; Schreiber Alan; Hackam David J
Enterocyte TLR4 mediates phagocytosis and translocation of bacteria across the intestinal barrier.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(5):3070-9.
2006: Oh H-Y; Namkoong S; Lee S-J; Por E; Kim C-K; Billiar T R; Han J-A; Ha K-S; Chung H-T; Kwon Y-G; Lee H; Kim Y-M
Dexamethasone protects primary cultured hepatocytes from death receptor-mediated apoptosis by upregulation of cFLIP.
Cell death and differentiation 2006;13(3):512-23.
2005: Levy Ryan M; Prince Jose M; Billiar Timothy R
Nitric oxide: a clinical primer.
Critical care medicine 2005;33(12 Suppl):S492-5.
2005: Tsung Allan; Hoffman Rosemary A; Izuishi Kunihiko; Critchlow Nathan D; Nakao Atsunori; Chan Meagan H; Lotze Michael T; Geller David A; Billiar Timothy R
Hepatic ischemia/reperfusion injury involves functional TLR4 signaling in nonparenchymal cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(11):7661-8.
2005: Stoyanovsky Detcho A; Tyurina Yulia Y; Tyurin Vladimir A; Anand Deepthi; Mandavia Dhara N; Gius David; Ivanova Juliana; Pitt Bruce; Billiar Timothy R; Kagan Valerian E
Thioredoxin and lipoic acid catalyze the denitrosation of low molecular weight and protein S-nitrosothiols.
Journal of the American Chemical Society 2005;127(45):15815-23.
2005: Kim P K M; Vallabhaneni R; Zuckerbraun B S; McCloskey C; Vodovotz Y; Billiar T R
Hypoxia renders hepatocytes susceptible to cell death by nitric oxide.
Cellular and molecular biology (Noisy-le-Grand, France) 2005;51(3):329-35.
2005: Loughran P A; Stolz D B; Vodovotz Y; Watkins S C; Simmons R L; Billiar T R
Monomeric inducible nitric oxide synthase localizes to peroxisomes in hepatocytes.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(39):13837-42.
2005: Chen Tracy; Pearce Linda L; Peterson Jim; Stoyanovsky Detcho; Billiar Timothy R
Glutathione depletion renders rat hepatocytes sensitive to nitric oxide donor-mediated toxicity.
Hepatology (Baltimore, Md.) 2005;42(3):598-607.
2005: Lagoa Claudio E; Vodovotz Yoram; Stolz Donna B; Lhuillier Franck; McCloskey Carol; Gallo David; Yang Runkuan; Ustinova Elena; Fink Mitchell P; Billiar Timothy R; Mars Wendy M
The role of hepatic type 1 plasminogen activator inhibitor (PAI-1) during murine hemorrhagic shock.
Hepatology (Baltimore, Md.) 2005;42(2):390-9.
2005: Nakao Atsunori; Murase Noriko; Ho Chien; Toyokawa Hideyoshi; Billiar Timothy R; Kanno Shinichi
Biliverdin administration prevents the formation of intimal hyperplasia induced by vascular injury.
Circulation 2005;112(4):587-91.
2005: Chow Carson C; Clermont Gilles; Kumar Rukmini; Lagoa Claudio; Tawadrous Zacharia; Gallo David; Betten Binnie; Bartels John; Constantine Gregory; Fink Mitchell P; Billiar Timothy R; Vodovotz Yoram
The acute inflammatory response in diverse shock states.
Shock (Augusta, Ga.) 2005;24(1):74-84.
2005: Zuckerbraun Brian S; McCloskey Carol A; Gallo David; Liu Fang; Ifedigbo Emeka; Otterbein Leo E; Billiar Timothy R
Carbon monoxide prevents multiple organ injury in a model of hemorrhagic shock and resuscitation.
Shock (Augusta, Ga.) 2005;23(6):527-32.
2005: Bayir Hülya; Kagan Valerian E; Borisenko Grigory G; Tyurina Yulia Y; Janesko Keri L; Vagni Vincent A; Billiar Timothy R; Williams Deborah L; Kochanek Patrick M
Enhanced oxidative stress in iNOS-deficient mice after traumatic brain injury: support for a neuroprotective role of iNOS.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2005;25(6):673-84.
2005: Scott Melanie J; Liu Shubing; Su Grace L; Vodovotz Yoram; Billiar Timothy R
Hepatocytes enhance effects of lipopolysaccharide on liver nonparenchymal cells through close cell interactions.
Shock (Augusta, Ga.) 2005;23(5):453-8.
2005: Wehner Sven; Schwarz Nicolas T; Hundsdoerfer Ricarda; Hierholzer Christian; Tweardy David J; Billiar Timothy R; Bauer Anthony J; Kalff Joerg C
Induction of IL-6 within the rodent intestinal muscularis after intestinal surgical stress.
Surgery 2005;137(4):436-46.
2005: Tsung Allan; Sahai Rohit; Tanaka Hiroyuki; Nakao Atsunori; Fink Mitchell P; Lotze Michael T; Yang Huan; Li Jianhua; Tracey Kevin J; Geller David A; Billiar Timothy R
The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion.
The Journal of experimental medicine 2005;201(7):1135-43.
2005: Nakao Atsunori; Neto Joao Seda; Kanno Shinichi; Stolz Donna B; Kimizuka Kei; Liu Fang; Bach Fritz H; Billiar Timothy R; Choi Augustine Mk; Otterbein Leo E; Murase Noriko
Protection against ischemia/reperfusion injury in cardiac and renal transplantation with carbon monoxide, biliverdin and both.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2005;5(2):282-91.
2004: Vodovotz Yoram; Kim Peter K M; Bagci Elife Zerrin; Ermentrout G Bard; Chow Carson C; Bahar Ivet; Billiar Timothy R
Inflammatory modulation of hepatocyte apoptosis by nitric oxide: in vivo, in vitro, and in silico studies.
Current molecular medicine 2004;4(7):753-62.
2004: Cook Tracy; Wang Zifa; Alber Sean; Liu Kaihong; Watkins Simon C; Vodovotz Yoram; Billiar Timothy R; Blumberg David
Nitric oxide and ionizing radiation synergistically promote apoptosis and growth inhibition of cancer by activating p53.
Cancer research 2004;64(21):8015-21.
2004: Park Sang-Youel; Seol Jae-Won; Lee You-Jin; Cho Jong-Hoo; Kang Hyung-Sub; Kim In-Shik; Park Soo-Hyun; Kim Tae-Hyoung; Yim John H; Kim Moonil; Billiar Timothy R; Seol Dai-Wu
IFN-gamma enhances TRAIL-induced apoptosis through IRF-1.
European journal of biochemistry / FEBS 2004;271(21):4222-8.
2004: McCloskey Carol A; Kameneva Marina V; Uryash Arkady; Gallo David J; Billiar Timothy R
Tissue hypoxia activates JNK in the liver during hemorrhagic shock.
Shock (Augusta, Ga.) 2004;22(4):380-6.
2004: Kim Mi-Hyang; Billiar Timothy R; Seol Dai-Wu
The secretable form of trimeric TRAIL, a potent inducer of apoptosis.
Biochemical and biophysical research communications 2004;321(4):930-5.
2004: Chang Kwang; Lee Seon-Jin; Cheong Ilyoung; Billiar Timothy R; Chung Hun-Taeg; Han Jeong-A; Kwon Young-Guen; Ha Kwon-Soo; Kim Young-Myeong
Nitric oxide suppresses inducible nitric oxide synthase expression by inhibiting post-translational modification of IkappaB.
Experimental & molecular medicine 2004;36(4):311-24.
2004: Kanno Shinichi; Kim Peter K M; Sallam Karim; Lei Jing; Billiar Timothy R; Shears Larry L
Nitric oxide facilitates cardiomyogenesis in mouse embryonic stem cells.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(33):12277-81.
2004: Kim Moonil; Park Sang-Youel; Pai Hyun-Sook; Kim Tae-Hyoung; Billiar Timothy R; Seol Dai-Wu
Hypoxia inhibits tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by blocking Bax translocation.
Cancer research 2004;64(12):4078-81.
2004: Billiar Timothy R; Peitzman Andrew B
The Department of Surgery at the School of Medicine at the University Of Pittsburgh, Pittsburgh, Pa.
Archives of surgery (Chicago, Ill. : 1960) 2004;139(5):466-8.
2004: Wang Zifa; Cook Tracy; Alber Sean; Liu Kaihong; Kovesdi Imre; Watkins Simon K; Vodovotz Yoram; Billiar Timothy R; Blumberg David
Adenoviral gene transfer of the human inducible nitric oxide synthase gene enhances the radiation response of human colorectal cancer associated with alterations in tumor vascularity.
Cancer research 2004;64(4):1386-95.
2004: Kim Peter K M; Armstrong Michaele; Liu Ye; Yan Peng; Bucher Brian; Zuckerbraun Brian S; Gambotto Andrea; Billiar Timothy R; Yim John H
IRF-1 expression induces apoptosis and inhibits tumor growth in mouse mammary cancer cells in vitro and in vivo.
Oncogene 2004;23(5):1125-35.
2004: Hierholzer Christian; Kalff Jörg C; Billiar Timothy R; Bauer Anthony J; Tweardy David J; Harbrecht Brian G
Induced nitric oxide promotes intestinal inflammation following hemorrhagic shock.
American journal of physiology. Gastrointestinal and liver physiology 2004;286(2):G225-33.
2004: Kim Peter K M; Zuckerbraun Brian S; Otterbein Leo E; Vodovotz Yoram; Billiar Timothy R
'Til cell death do us part: nitric oxide and mechanisms of hepatotoxicity.
Biological chemistry 2004;385(1):11-5.
2004: Song Ruiping; Mahidhara Raja S; Zhou Zhihong; Hoffman Rosemary A; Seol Dai-Wu; Flavell Richard A; Billiar Timothy R; Otterbein Leo E; Choi Augustine M K
Carbon monoxide inhibits T lymphocyte proliferation via caspase-dependent pathway.
Journal of immunology (Baltimore, Md. : 1950) 2004;172(2):1220-6.
2004: Schwarz Nicolas T; Kalff Jörg C; Türler Andreas; Speidel Nicola; Grandis Jennifer R; Billiar Timothy R; Bauer Anthony J
Selective jejunal manipulation causes postoperative pan-enteric inflammation and dysmotility.
Gastroenterology 2004;126(1):159-69.
2004: Kameneva Marina V; Wu Zhongjun J; Uraysh Arkady; Repko Brandon; Litwak Kenneth N; Billiar Timothy R; Fink Mitchell P; Simmons Richard L; Griffith Bartley P; Borovetz Harvey S
Blood soluble drag-reducing polymers prevent lethality from hemorrhagic shock in acute animal experiments.
Biorheology 2004;41(1):53-64.
2003: Zuckerbraun Brian S; Billiar Timothy R; Otterbein Sherrie L; Kim Peter K M; Liu Fang; Choi Augustine M K; Bach Fritz H; Otterbein Leo E
Carbon monoxide protects against liver failure through nitric oxide-induced heme oxygenase 1.
The Journal of experimental medicine 2003;198(11):1707-16.
2003: McCloskey Carol A; Zuckerbraun Brian S; Gallo David J; Vodovotz Yoram; Billiar Timothy R
A role for angiotensin II in the activation of extracellular signal-regulated kinases in the liver during hemorrhagic shock.
Shock (Augusta, Ga.) 2003;20(4):316-9.
2003: Chen Tracy; Zamora Ruben; Zuckerbraun Brian; Billiar Timothy R
Role of nitric oxide in liver injury.
Current molecular medicine 2003;3(6):519-26.
2003: Mahidhara Raja S; Hoffman Rosemary A; Huang Sulan; Wolf-Johnston Amanda; Vodovotz Yoram; Simmons Richard L; Billiar Timothy R
Nitric oxide-mediated inhibition of caspase-dependent T lymphocyte proliferation.
Journal of leukocyte biology 2003;74(3):403-11.
2003: Zuckerbraun Brian S; Shapiro Richard A; Billiar Timothy R; Tzeng Edith
RhoA influences the nuclear localization of extracellular signal-regulated kinases to modulate p21Waf/Cip1 expression.
Circulation 2003;108(7):876-81.
2003: Kim Peter K M; Park Sang-Youel; Koty Patrick P; Hua Yun; Luketich James D; Billiar Timothy R
Fas-associating death domain protein overexpression induces apoptosis in lung cancer cells.
The Journal of thoracic and cardiovascular surgery 2003;125(6):1336-42.
2003: Schwentker Ann; Billiar Timothy R
Nitric oxide and wound repair.
The Surgical clinics of North America 2003;83(3):521-30.
2003: Ha Kwon-Soo; Kim Ki-Mo; Kwon Young-Guen; Bai Se-Kyung; Nam Woo-Dong; Yoo Young-Min; Kim Peter K M; Chung Hun-Taeg; Billiar Timothy R; Kim Young-Myeong
Nitric oxide prevents 6-hydroxydopamine-induced apoptosis in PC12 cells through cGMP-dependent PI3 kinase/Akt activation.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(9):1036-47.
2003: Weller Richard; Schwentker Ann; Billiar Timothy R; Vodovotz Yoram
Autologous nitric oxide protects mouse and human keratinocytes from ultraviolet B radiation-induced apoptosis.
American journal of physiology. Cell physiology 2003;284(5):C1140-8.
2003: Hierholzer C; Billiar T R; Tweardy D J; Harbrecht B
Reduced hepatic transcription factor activation and expression of IL-6 and ICAM-1 after hemorrhage by NO scavenging.
Archives of orthopaedic and trauma surgery 2003;123(2-3):55-9.
2003: Zuckerbraun Brian S; Billiar Timothy R
Heme oxygenase-1: a cellular Hercules.
Hepatology (Baltimore, Md.) 2003;37(4):742-4.
2003: Kim Peter K M; Billiar Timothy R
There's NO business like p53 business: nitric oxide regulates phosphorylation of p53 in chronic inflammatory disease.
Cell cycle (Georgetown, Tex.) 2003;2(2):111-2.
2003: Chung Peter; Cook Tracy; Liu Kaihong; Vodovotz Yoram; Zamora Ruben; Finkelstein Sydney; Billiar Timothy; Blumberg David
Overexpression of the human inducible nitric oxide synthase gene enhances radiation-induced apoptosis in colorectal cancer cells via a caspase-dependent mechanism.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2003;8(2):119-26.
2003: Kibbe Melina R; Johnnides Christopher; Gleixner Susan; Kovesdi Imre; Lizonova Alena; Zuckerbraun Brian; Billiar Timothy R; Tzeng Edith; Muluk Satish C
Regulation of tissue factor expression in smooth muscle cells with nitric oxide.
Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter 2003;37(3):650-9.
2003: Kalff Jörg C; Türler Andreas; Schwarz Nicolas T; Schraut Wolfgang H; Lee Kenneth K W; Tweardy David J; Billiar Timothy R; Simmons Richard L; Bauer Anthony J
Intra-abdominal activation of a local inflammatory response within the human muscularis externa during laparotomy.
Annals of surgery 2003;237(3):301-15.
2003: Kim Peter K M; Weller Richard; Hua Yun; Billiar Timothy R
Ultraviolet irradiation increases FADD protein in apoptotic human keratinocytes.
Biochemical and biophysical research communications 2003;302(2):290-5.
2003: Collins Joy L; Vodovotz Yoram; Hierholzer Christian; Villavicencio Raphael T; Liu Shubing; Alber Sean; Gallo David; Stolz Donna B; Watkins Simon C; Godfrey Anthony; Gooding William; Kelly Edward; Peitzman Andrew B; Billiar Timothy R
Characterization of the expression of inducible nitric oxide synthase in rat and human liver during hemorrhagic shock.
Shock (Augusta, Ga.) 2003;19(2):117-22.
2003: Otterbein Leo E; Zuckerbraun Brian S; Haga Manabu; Liu Fang; Song Ruiping; Usheva Anny; Stachulak Christina; Bodyak Natalya; Smith R Neal; Csizmadia Eva; Tyagi Shivraj; Akamatsu Yorihiro; Flavell Richard J; Billiar Timothy R; Tzeng Edith; Bach Fritz H; Choi Augustine M K; Soares Miguel P
Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury.
Nature medicine 2003;9(2):183-90.
2002: Park Joon-Hong; Na Hee-Jun; Kwon Young-Guen; Ha Kwon-Soo; Lee Seon-Jin; Kim Chun-Ki; Lee Kwang-Soon; Yoneyama Toshie; Hatakeyama Kazuyuki; Kim Peter K M; Billiar Timothy R; Kim Young-Myeong
Nitric oxide (NO) pretreatment increases cytokine-induced NO production in cultured rat hepatocytes by suppressing GTP cyclohydrolase I feedback inhibitory protein level and promoting inducible NO synthase dimerization.
The Journal of biological chemistry 2002;277(49):47073-9.
2002: Zamora Ruben; Vodovotz Yoram; Aulak Kulwant S; Kim Peter K M; Kane John M; Alarcon Louis; Stuehr Dennis J; Billiar Timothy R
A DNA microarray study of nitric oxide-induced genes in mouse hepatocytes: implications for hepatic heme oxygenase-1 expression in ischemia/reperfusion.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2002;7(3):165-86.
2002: Carty Sally E; Colson Yolonda L; Garvey Laura S; Schuchert Vaishali D; Schwentker Ann; Tzeng Edith; Corcoran Noreen A; Simmons Richard L; Webster Marshall W; Billiar Timothy R
Maternity policy and practice during surgery residency: how we do it.
Surgery 2002;132(4):682-7; discussion 687-8.
2002: Kim Peter K M; Wang Yinna; Gambotto Andrea; Kim Young-Myeong; Weller Richard; Zuckerbraun Brian S; Hua Yun; Watkins Simon C; Billiar Timothy R
Hepatocyte Fas-associating death domain protein/mediator of receptor-induced toxicity (FADD/MORT1) levels increase in response to pro-apoptotic stimuli.
The Journal of biological chemistry 2002;277(41):38855-62.
2002: Schwentker Ann; Vodovotz Yoram; Weller Richard; Billiar Timothy R
Nitric oxide and wound repair: role of cytokines?
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2002;7(1):1-10.
2002: Zenati Mazen S; Billiar Timothy R; Townsend Ricard N; Peitzman Andrew B; Harbrecht Brian G
A brief episode of hypotension increases mortality in critically ill trauma patients.
The Journal of trauma 2002;53(2):232-6; discussion 236-7.
2002: Stolz Donna Beer; Zamora Ruben; Vodovotz Yoram; Loughran Patricia A; Billiar Timothy R; Kim Young-Myeong; Simmons Richard L; Watkins Simon C
Peroxisomal localization of inducible nitric oxide synthase in hepatocytes.
Hepatology (Baltimore, Md.) 2002;36(1):81-93.
2002: Liu Shubing; Gallo David J; Green Angela M; Williams Debra L; Gong Xiaoyan; Shapiro Richard A; Gambotto Andrea A; Humphris Elisabeth L; Vodovotz Yoram; Billiar Timothy R
Role of toll-like receptors in changes in gene expression and NF-kappa B activation in mouse hepatocytes stimulated with lipopolysaccharide.
Infection and immunity 2002;70(7):3433-42.
2002: Schwentker Ann; Billiar Timothy R
Inducible nitric oxide synthase: from cloning to therapeutic applications.
World journal of surgery 2002;26(7):772-8.
2002: Wang Yinna; Vodovotz Yoram; Kim Peter K M; Zamora Ruben; Billiar Timothy R
Mechanisms of hepatoprotection by nitric oxide.
Annals of the New York Academy of Sciences 2002;962():415-22.
2002: Koo Myoung-Sook; Kwo Young-Guen; Park Joon-Hong; Choi Won-Jin; Billiar Timothy R; Kim Young-Myeong
Signaling and function of caspase and c-jun N-terminal kinase in cisplatin-induced apoptosis.
Molecules and cells 2002;13(2):194-201.
2002: Song Young K; Billiar Timothy R; Lee Yong J
Role of galectin-3 in breast cancer metastasis: involvement of nitric oxide.
The American journal of pathology 2002;160(3):1069-75.
2002: Kibbe Melina R; Li Jianrong; Nie Suhua; Choi Byung Min; Kovesdi Imre; Lizonova Alena; Billiar Timothy R; Tzeng Edith
Potentiation of nitric oxide-induced apoptosis in p53-/- vascular smooth muscle cells.
American journal of physiology. Cell physiology 2002;282(3):C625-34.
2002: Hierholzer Christian; Billiar Timothy R; Tweardy David J
Requirements for NF-kappaB activation in hemorrhagic shock.
Archives of orthopaedic and trauma surgery 2002;122(1):44-7.
2002: Park Sang-Youel; Billiar Timothy R; Seol Dai-Wu
IFN-gamma inhibition of TRAIL-induced IAP-2 upregulation, a possible mechanism of IFN-gamma-enhanced TRAIL-induced apoptosis.
Biochemical and biophysical research communications 2002;291(2):233-6.
2002: Hierholzer Christian; Menezes John M; Ungeheuer Andreas; Billiar Timothy R; Tweardy David J; Harbrecht Brian G
A nitric oxide scavenger protects against pulmonary inflammation following hemorrhagic shock.
Shock (Augusta, Ga.) 2002;17(2):98-103.
2002: Norris Rob; Woods Randy; Harbrecht Brian; Fabian Timothy; Rhodes Michael; Morris John; Billiar Timothy R; Courcoulas Anita P; Udekwu Anthony O; Stinson Christine; Peitzman Andrew B
TRISS unexpected survivors: an outdated standard?
The Journal of trauma 2002;52(2):229-34.
2002: Park Sang-Youel; Billiar Timothy R; Seol Dai-Wu
Hypoxia inhibition of apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).
Biochemical and biophysical research communications 2002;291(1):150-3.
2002: Menezes John M; Hierholzer Chris; Watkins Simon C; Billiar Timothy R; Peitzman Andrew B; Harbrecht Brian G
The modulation of hepatic injury and heat shock expression by inhibition of inducible nitric oxide synthase after hemorrhagic shock.
Shock (Augusta, Ga.) 2002;17(1):13-8.
2001: Schwarz N T; Kalff J C; Türler A; Engel B M; Watkins S C; Billiar T R; Bauer A J
Prostanoid production via COX-2 as a causative mechanism of rodent postoperative ileus.
Gastroenterology 2001;121(6):1354-71.
2001: Zamora R; Alarcon L; Vodovotz Y; Betten B; Kim P K; Gibson K F; Billiar T R
Nitric oxide suppresses the expression of Bcl-2 binding protein BNIP3 in hepatocytes.
The Journal of biological chemistry 2001;276(50):46887-95.
2001: Lee V G; Johnson M L; Baust J; Laubach V E; Watkins S C; Billiar T R
The roles of iNOS in liver ischemia-reperfusion injury.
Shock (Augusta, Ga.) 2001;16(5):355-60.
2001: Ameredes B T; Zamora R; Gibson K F; Billiar T R; Dixon-McCarthy B; Watkins S; Calhoun W J
Increased nitric oxide production by airway cells of sensitized and challenged IL-10 knockout mice.
Journal of leukocyte biology 2001;70(5):730-6.
2001: Collins J L; Vodovotz Y; Yoneyama T; Hatakeyama K; Green A M; Billiar T R
Catecholamines decrease nitric oxide production by cytokine-stimulated hepatocytes.
Surgery 2001;130(2):256-64.
2001: Kim P K; Billiar T R
Give me iNOS or give me death.
Hepatology (Baltimore, Md.) 2001;34(2):436-7.
2001: Kibbe M R; Tzeng E; Gleixner S L; Watkins S C; Kovesdi I; Lizonova A; Makaroun M S; Billiar T R; Rhee R Y
Adenovirus-mediated gene transfer of human inducible nitric oxide synthase in porcine vein grafts inhibits intimal hyperplasia.
Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter 2001;34(1):156-65.
2001: Zamora R; Vodovotz Y; Alarcon L; Betten B; Loughran P A; Aulak K S; Stuehr D J; Gibson K F; Billiar T R
Nitric oxide from the inducible nitric oxide synthase (iNOS) increases the expression of cytochrome P450 2E1 in iNOS-null hepatocytes in the absence of inflammatory stimuli.
Archives of biochemistry and biophysics 2001;390(2):287-94.
2001: Kwon Y G; Min J K; Kim K M; Lee D J; Billiar T R; Kim Y M
Sphingosine 1-phosphate protects human umbilical vein endothelial cells from serum-deprived apoptosis by nitric oxide production.
The Journal of biological chemistry 2001;276(14):10627-33.
2001: Lee Y J; Lee K H; Kim H R; Jessup J M; Seol D W; Kim T H; Billiar T R; Song Y K
Sodium nitroprusside enhances TRAIL-induced apoptosis via a mitochondria-dependent pathway in human colorectal carcinoma CX-1 cells.
Oncogene 2001;20(12):1476-85.
2001: Hierholzer C; Kalff J C; Chakraborty A; Watkins S C; Billiar T R; Bauer A J; Tweardy D J
Impaired gut contractility following hemorrhagic shock is accompaied by IL-6 and G-CSF production and neutrophil infiltration.
Digestive diseases and sciences 2001;46(2):230-41.
2001: Harbrecht B G; Doyle H R; Clancy K D; Townsend R N; Billiar T R; Peitzman A B
The impact of liver dysfunction on outcome in patients with multiple injuries.
The American surgeon 2001;67(2):122-6.
2001: Seol D W; Li J; Seol M H; Park S Y; Talanian R V; Billiar T R
Signaling events triggered by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL): caspase-8 is required for TRAIL-induced apoptosis.
Cancer research 2001;61(3):1138-43.
2001: Kochanek P M; Janesko K L; Jenkins L W; Yan H Q; Kibbe M R; Robichaud P; Wooditch A C; Clark R S; Dixon C E; Marion D W; Billiar T R
Adenovirus-mediated transfer and expression of beta-gal in injured hippocampus after traumatic brain injury in mice.
Journal of neurotrauma 2001;18(1):73-82.
2001: Vodovotz Y; Liu S; McCloskey C; Shapiro R; Green A; Billiar T R
The hepatocyte as a microbial product-responsive cell.
Journal of endotoxin research 2001;7(5):365-73.
2001: Han Y J; Kwon Y G; Chung H T; Lee S K; Simmons R L; Billiar T R; Kim Y M
Antioxidant enzymes suppress nitric oxide production through the inhibition of NF-kappa B activation: role of H(2)O(2) and nitric oxide in inducible nitric oxide synthase expression in macrophages.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 2001;5(5):504-13.
2001: Hierholzer C; Harbrecht B G; Billiar T R; Tweardy D J
Hypoxia-inducible factor-1 activation and cyclo-oxygenase-2 induction are early reperfusion-independent inflammatory events in hemorrhagic shock.
Archives of orthopaedic and trauma surgery 2001;121(4):219-22.
2000: Lee P C; Kibbe M R; Schuchert M J; Stolz D B; Watkins S C; Griffith B P; Billiar T R; Shears L L
Nitric oxide induces angiogenesis and upregulates alpha(v)beta(3) integrin expression on endothelial cells.
Microvascular research 2000;60(3):269-80.
2000: Kim Y M; Kim T H; Chung H T; Talanian R V; Yin X M; Billiar T R
Nitric oxide prevents tumor necrosis factor alpha-induced rat hepatocyte apoptosis by the interruption of mitochondrial apoptotic signaling through S-nitrosylation of caspase-8.
Hepatology (Baltimore, Md.) 2000;32(4 Pt 1):770-8.
2000: Liu S; Salyapongse A N; Geller D A; Vodovotz Y; Billiar T R
Hepatocyte toll-like receptor 2 expression in vivo and in vitro: role of cytokines in induction of rat TLR2 gene expression by lipopolysaccharide.
Shock (Augusta, Ga.) 2000;14(3):361-5.
2000: Geller D A; Di Silvio M; Billiar T R; Hatakeyama K
GTP cyclohydrolase I is coinduced in hepatocytes stimulated to produce nitric oxide.
Biochemical and biophysical research communications 2000;276(2):633-41.
2000: Seol D W; Billiar T R
Cysteine 230 modulates tumor necrosis factor-related apoptosis-inducing ligand activity.
Cancer research 2000;60(12):3152-4.
2000: Liu S; Morris S M; Nie S; Shapiro R A; Billiar T R
cAMP induces CD14 expression in murine macrophages via increased transcription.
Journal of leukocyte biology 2000;67(6):894-901.
2000: Villavicencio R T; Liu S; Kibbe M R; Williams D L; Ganster R W; Dyer K F; Tweardy D J; Billiar T R; Pitt B R
Induced nitric oxide inhibits IL-6-induced stat3 activation and type II acute phase mRNA expression.
Shock (Augusta, Ga.) 2000;13(6):441-5.
2000: Kibbe M R; Li J; Nie S; Watkins S C; Lizonova A; Kovesdi I; Simmons R L; Billiar T R; Tzeng E
Inducible nitric oxide synthase (iNOS) expression upregulates p21 and inhibits vascular smooth muscle cell proliferation through p42/44 mitogen-activated protein kinase activation and independent of p53 and cyclic guanosine monophosphate.
Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter 2000;31(6):1214-28.
2000: Zamora R; Vodovotz Y; Billiar T R
Inducible nitric oxide synthase and inflammatory diseases.
Molecular medicine (Cambridge, Mass.) 2000;6(5):347-73.
2000: Liu S; Shapiro R A; Nie S; Zhu D; Vodovotz Y; Billiar T R
Characterization of rat CD14 promoter and its regulation by transcription factors AP1 and Sp family proteins in hepatocytes.
Gene 2000;250(1-2):137-47.
2000: Jo M; Kim T H; Seol D W; Esplen J E; Dorko K; Billiar T R; Strom S C
Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand.
Nature medicine 2000;6(5):564-7.
2000: Mahidhara R; Billiar T R
Apoptosis in sepsis.
Critical care medicine 2000;28(4 Suppl):N105-13.
2000: Kibbe M R; Billiar T R; Tzeng E
Gene therapy for restenosis.
Circulation research 2000;86(8):829-33.
2000: Li J; Yang S; Billiar T R
Cyclic nucleotides suppress tumor necrosis factor alpha-mediated apoptosis by inhibiting caspase activation and cytochrome c release in primary hepatocytes via a mechanism independent of Akt activation.
The Journal of biological chemistry 2000;275(17):13026-34.
2000: Kim Y M; Chung H T; Simmons R L; Billiar T R
Cellular non-heme iron content is a determinant of nitric oxide-mediated apoptosis, necrosis, and caspase inhibition.
The Journal of biological chemistry 2000;275(15):10954-61.
2000: Lee P C; Wang Z L; Qian S; Watkins S C; Lizonova A; Kovesdi I; Tzeng E; Simmons R L; Billiar T R; Shears L L
Endothelial nitric oxide synthase protects aortic allografts from the development of transplant arteriosclerosis.
Transplantation 2000;69(6):1186-92.
2000: Kibbe M R; Murdock A; Wickham T; Lizonova A; Kovesdi I; Nie S; Shears L; Billiar T R; Tzeng E
Optimizing cardiovascular gene therapy: increased vascular gene transfer with modified adenoviral vectors.
Archives of surgery (Chicago, Ill. : 1960) 2000;135(2):191-7.
2000: Kibbe M R; Nie S; Seol D W; Kovesdi I; Lizonova A; Makaroun M; Billiar T R; Tzeng E
Nitric oxide prevents p21 degradation with the ubiquitin-proteasome pathway in vascular smooth muscle cells.
Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter 2000;31(2):364-74.
2000: Kalff J C; Schraut W H; Billiar T R; Simmons R L; Bauer A J
Role of inducible nitric oxide synthase in postoperative intestinal smooth muscle dysfunction in rodents.
Gastroenterology 2000;118(2):316-27.
1999: Lee P C; Shears L L; Billiar T R
Role of inducible nitric oxide synthase in transplant arteriosclerosis.
Clinical and experimental pharmacology & physiology 1999;26(12):1013-5.
1999: Hierholzer C; Kalff J C; Audolfsson G; Billiar T R; Tweardy D J; Bauer A J
Molecular and functional contractile sequelae of rat intestinal ischemia/reperfusion injury.
Transplantation 1999;68(9):1244-54.
1999: Li J; Billiar T R
The anti-apoptotic actions of nitric oxide in hepatocytes.
Cell death and differentiation 1999;6(10):952-5.
1999: Salyapongse A N; Billiar T R; Edington H
Gene therapy and tissue engineering.
Clinics in plastic surgery 1999;26(4):663-76, x.
1999: Lee P C; Salyapongse A N; Bragdon G A; Shears L L; Watkins S C; Edington H D; Billiar T R
Impaired wound healing and angiogenesis in eNOS-deficient mice.
The American journal of physiology 1999;277(4 Pt 2):H1600-8.
1999: Sinz E H; Kochanek P M; Dixon C E; Clark R S; Carcillo J A; Schiding J K; Chen M; Wisniewski S R; Carlos T M; Williams D; DeKosky S T; Watkins S C; Marion D W; Billiar T R
Inducible nitric oxide synthase is an endogenous neuroprotectant after traumatic brain injury in rats and mice.
The Journal of clinical investigation 1999;104(5):647-56.
1999: Kibbe M R; Nie S; Yoneyama T; Hatakeyama K; Lizonova A; Kovesdi I; Billiar T R; Tzeng E
Optimization of ex vivo inducible nitric oxide synthase gene transfer to vein grafts.
Surgery 1999;126(2):323-9.
1999: Eskandari M K; Kalff J C; Billiar T R; Lee K K; Bauer A J
LPS-induced muscularis macrophage nitric oxide suppresses rat jejunal circular muscle activity.
The American journal of physiology 1999;277(2 Pt 1):G478-86.
1999: Kim Y M; Chung H T; Kim S S; Han J A; Yoo Y M; Kim K M; Lee G H; Yun H Y; Green A; Li J; Simmons R L; Billiar T R
Nitric oxide protects PC12 cells from serum deprivation-induced apoptosis by cGMP-dependent inhibition of caspase signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999;19(16):6740-7.
1999: Kalff J C; Carlos T M; Schraut W H; Billiar T R; Simmons R L; Bauer A J
Surgically induced leukocytic infiltrates within the rat intestinal muscularis mediate postoperative ileus.
Gastroenterology 1999;117(2):378-87.
1999: Menezes J; Hierholzer C; Watkins S C; Lyons V; Peitzman A B; Billiar T R; Tweardy D J; Harbrecht B G
A novel nitric oxide scavenger decreases liver injury and improves survival after hemorrhagic shock.
The American journal of physiology 1999;277(1 Pt 1):G144-51.
1999: Peitzman A B; Courcoulas A P; Stinson C; Udekwu A O; Billiar T R; Harbrecht B G
Trauma center maturation: quantification of process and outcome.
Annals of surgery 1999;230(1):87-94.
1999: Orucevic A; Bechberger J; Green A M; Shapiro R A; Billiar T R; Lala P K
Nitric-oxide production by murine mammary adenocarcinoma cells promotes tumor-cell invasiveness.
International journal of cancer. Journal international du cancer 1999;81(6):889-96.
1999: Li J; Bombeck C A; Yang S; Kim Y M; Billiar T R
Nitric oxide suppresses apoptosis via interrupting caspase activation and mitochondrial dysfunction in cultured hepatocytes.
The Journal of biological chemistry 1999;274(24):17325-33.
1999: Tsukada K; Omert L A; Menezes J; Harbrecht B G; Miyagishima M; Hierholzer C; Billiar T R
Neutrophil accumulation and damage to the gastric mucosa in resuscitated hemorrhagic shock is independent of inducible nitric oxide synthase.
Shock (Augusta, Ga.) 1999;11(5):319-24.
1999: Li J; Billiar T R
Nitric Oxide. IV. Determinants of nitric oxide protection and toxicity in liver.
The American journal of physiology 1999;276(5 Pt 1):G1069-73.
1999: Chia S H; Murase N; Taylor B S; Billiar T R; Starzl T E; Geller D A
Adenoviral-mediated gene delivery to liver isografts: improved model of ex vivo gene transfer.
Transplantation proceedings 1999;31(1-2):475-6.
1999: Kim Y M; Bombeck C A; Billiar T R
Nitric oxide as a bifunctional regulator of apoptosis.
Circulation research 1999;84(3):253-6.
1999: Seol D W; Billiar T R
A caspase-9 variant missing the catalytic site is an endogenous inhibitor of apoptosis.
The Journal of biological chemistry 1999;274(4):2072-6.
1999: Hierholzer C; Kalff J C; Bednarski B; Memarzadeh F; Kim Y M; Billiar T R; Tweardy D J
Rapid and simultaneous activation of Stat3 and production of interleukin 6 in resuscitated hemorrhagic shock.
Archives of orthopaedic and trauma surgery 1999;119(5-6):332-6.
1998: Lee K H; Rico P; Billiar T R; Pinsky M R
Nitric oxide production after acute, unilateral hydrochloric acid-induced lung injury in a canine model.
Critical care medicine 1998;26(12):2042-7.
1998: Shah N S; Kelly E; Billiar T R; Marshall H M; Harbrecht B G; Udekwu A O; Peitzman A B
Utility of clinical parameters of tissue oxygenation in a quantitative model of irreversible hemorrhagic shock.
Shock (Augusta, Ga.) 1998;10(5):343-6.
1998: Kim Y M; Kim T H; Seol D W; Talanian R V; Billiar T R
Nitric oxide suppression of apoptosis occurs in association with an inhibition of Bcl-2 cleavage and cytochrome c release.
The Journal of biological chemistry 1998;273(47):31437-41.
1998: Liu S; Khemlani L S; Shapiro R A; Johnson M L; Liu K; Geller D A; Watkins S C; Goyert S M; Billiar T R
Expression of CD14 by hepatocytes: upregulation by cytokines during endotoxemia.
Infection and immunity 1998;66(11):5089-98.
1998: Shah N S; Billiar T R
Role of nitric oxide in inflammation and tissue injury during endotoxemia and hemorrhagic shock.
Environmental health perspectives 1998;106 Suppl 5():1139-43.
1998: Kim Y M; Talanian R V; Li J; Billiar T R
Nitric oxide prevents IL-1beta and IFN-gamma-inducing factor (IL-18) release from macrophages by inhibiting caspase-1 (IL-1beta-converting enzyme).
Journal of immunology (Baltimore, Md. : 1950) 1998;161(8):4122-8.
1998: Ceneviva G D; Tzeng E; Hoyt D G; Yee E; Gallagher A; Engelhardt J F; Kim Y M; Billiar T R; Watkins S A; Pitt B R
Nitric oxide inhibits lipopolysaccharide-induced apoptosis in pulmonary artery endothelial cells.
The American journal of physiology 1998;275(4 Pt 1):L717-28.
1998: Hierholzer C; Kalff J C; Billiar T R; Bauer A; Tweardy D J
Activation of STAT proteins following ischemia reperfusion injury demonstrates a distinct IL-6 and G-CSF mediated profile.
Transplantation proceedings 1998;30(6):2647.
1998: Shears L L; Kibbe M R; Murdock A D; Billiar T R; Lizonova A; Kovesdi I; Watkins S C; Tzeng E
Efficient inhibition of intimal hyperplasia by adenovirus-mediated inducible nitric oxide synthase gene transfer to rats and pigs in vivo.
Journal of the American College of Surgeons 1998;187(3):295-306.
1998: Hierholzer C; Kalff J C; Omert L; Tsukada K; Loeffert J E; Watkins S C; Billiar T R; Tweardy D J
Interleukin-6 production in hemorrhagic shock is accompanied by neutrophil recruitment and lung injury.
The American journal of physiology 1998;275(3 Pt 1):L611-21.
1998: Tzeng E; Billiar T R; Williams D L; Li J; Lizonova A; Kovesdi I; Kim Y M
Adenovirus-mediated inducible nitric oxide synthase gene transfer inhibits hepatocyte apoptosis.
Surgery 1998;124(2):278-83.
1998: Taylor B S; Alarcon L H; Billiar T R
Inducible nitric oxide synthase in the liver: regulation and function.
Biochemistry. Biokhimii?a 1998;63(7):766-81.
1998: Omert L; Tsukada K; Hierholzer C; Lyons V A; Carlos T M; Peitzman A B; Billiar T R
A role of neutrophils in the down-regulation of IL-6 and CD14 following hemorrhagic shock.
Shock (Augusta, Ga.) 1998;9(6):391-6.
1998: Taylor B S; de Vera M E; Ganster R W; Wang Q; Shapiro R A; Morris S M; Billiar T R; Geller D A
Multiple NF-kappaB enhancer elements regulate cytokine induction of the human inducible nitric oxide synthase gene.
The Journal of biological chemistry 1998;273(24):15148-56.
1998: Kim Y M; Son K; Hong S J; Green A; Chen J J; Tzeng E; Hierholzer C; Billiar T R
Inhibition of protein synthesis by nitric oxide correlates with cytostatic activity: nitric oxide induces phosphorylation of initiation factor eIF-2 alpha.
Molecular medicine (Cambridge, Mass.) 1998;4(3):179-90.
1998: Geller D A; Billiar T R
Molecular biology of nitric oxide synthases.
Cancer metastasis reviews 1998;17(1):7-23.
1998: Hierholzer C; Harbrecht B; Menezes J M; Kane J; MacMicking J; Nathan C F; Peitzman A B; Billiar T R; Tweardy D J
Essential role of induced nitric oxide in the initiation of the inflammatory response after hemorrhagic shock.
The Journal of experimental medicine 1998;187(6):917-28.
1998: Yamasaki K; Edington H D; McClosky C; Tzeng E; Lizonova A; Kovesdi I; Steed D L; Billiar T R
Reversal of impaired wound repair in iNOS-deficient mice by topical adenoviral-mediated iNOS gene transfer.
The Journal of clinical investigation 1998;101(5):967-71.
1998: Hierholzer C; Kelly E; Lyons V; Roedling E; Davies P; Billiar T R; Tweardy D J
G-CSF instillation into rat lungs mediates neutrophil recruitment, pulmonary edema, and hypoxia.
Journal of leukocyte biology 1998;63(2):169-74.
1998: Johnson M L; Billiar T R
Roles of nitric oxide in surgical infection and sepsis.
World journal of surgery 1998;22(2):187-96.
1998: Johnson M L; Shapiro R A; Billiar T R
Cloning and expression of human inducible nitric oxide synthase.
Methods in molecular biology (Clifton, N.J.) 1998;100():43-9.
1998: Hierholzer C; Kalff J C; Billiar T R; Tweardy D J
Activation of STAT proteins in the lung of rats following resuscitation from hemorrhagic shock.
Archives of orthopaedic and trauma surgery 1998;117(6-7):372-5.
1997: De Vera M E; Taylor B S; Wang Q; Shapiro R A; Billiar T R; Geller D A
Dexamethasone suppresses iNOS gene expression by upregulating I-kappa B alpha and inhibiting NF-kappa B.
The American journal of physiology 1997;273(6 Pt 1):G1290-6.
1997: Harbrecht B G; Wu B; Watkins S C; Billiar T R; Peitzman A B
Inhibition of nitric oxide synthesis during severe shock but not after resuscitation increases hepatic injury and neutrophil accumulation in hemorrhaged rats.
Shock (Augusta, Ga.) 1997;8(6):415-21.
1997: Kim Y M; Talanian R V; Billiar T R
Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms.
The Journal of biological chemistry 1997;272(49):31138-48.
1997: Li J; Billiar T R; Talanian R V; Kim Y M
Nitric oxide reversibly inhibits seven members of the caspase family via S-nitrosylation.
Biochemical and biophysical research communications 1997;240(2):419-24.
1997: Hierholzer C; Kelly E; Tsukada K; Loeffert E; Watkins S; Billiar T R; Tweardy D J
Hemorrhagic shock induces G-CSF expression in bronchial epithelium.
The American journal of physiology 1997;273(5 Pt 1):L1058-64.
1997: Taylor B S; Kim Y M; Wang Q; Shapiro R A; Billiar T R; Geller D A
Nitric oxide down-regulates hepatocyte-inducible nitric oxide synthase gene expression.
Archives of surgery (Chicago, Ill. : 1960) 1997;132(11):1177-83.
1997: Ou J; Carlos T M; Watkins S C; Saavedra J E; Keefer L K; Kim Y M; Harbrecht B G; Billiar T R
Differential effects of nonselective nitric oxide synthase (NOS) and selective inducible NOS inhibition on hepatic necrosis, apoptosis, ICAM-1 expression, and neutrophil accumulation during endotoxemia.
Nitric oxide : biology and chemistry / official journal of the Nitric Oxide Society 1997;1(5):404-16.
1997: Marshall H P; Capone A; Courcoulas A P; Harbrecht B G; Billiar T R; Udekwu A O; Peitzman A B
Effects of hemodilution on long-term survival in an uncontrolled hemorrhagic shock model in rats.
The Journal of trauma 1997;43(4):673-9.
1997: Powell M; Courcoulas A; Gardner M; Lynch J; Harbrecht B G; Udekwu A O; Billiar T R; Federle M; Ferris J; Meza M P; Peitzman A B
Management of blunt splenic trauma: significant differences between adults and children.
Surgery 1997;122(4):654-60.
1997: Shears L L; Kawaharada N; Tzeng E; Billiar T R; Watkins S C; Kovesdi I; Lizonova A; Pham S M
Inducible nitric oxide synthase suppresses the development of allograft arteriosclerosis.
The Journal of clinical investigation 1997;100(8):2035-42.
1997: Eskandari M K; Kalff J C; Billiar T R; Lee K K; Bauer A J
Lipopolysaccharide activates the muscularis macrophage network and suppresses circular smooth muscle activity.
The American journal of physiology 1997;273(3 Pt 1):G727-34.
1997: Tzeng E; Billiar T R
Nitric oxide and the surgical patient. Identifying therapeutic targets.
Archives of surgery (Chicago, Ill. : 1960) 1997;132(9):977-82.
1997: Tzeng E; Kim Y M; Pitt B R; Lizonova A; Kovesdi I; Billiar T R
Adenoviral transfer of the inducible nitric oxide synthase gene blocks endothelial cell apoptosis.
Surgery 1997;122(2):255-63.
1997: Harbrecht B G; Kim Y M; Wirant E A; Simmons R L; Billiar T R
Timing of prostaglandin exposure is critical for the inhibition of LPS- or IFN-gamma-induced macrophage NO synthesis by PGE2.
Journal of leukocyte biology 1997;61(6):712-20.
1997: Kane J M; Shears L L; Hierholzer C; Ambs S; Billiar T R; Posner M C
Chronic hepatitis C virus infection in humans: induction of hepatic nitric oxide synthase and proposed mechanisms for carcinogenesis.
The Journal of surgical research 1997;69(2):321-4.
1997: Cicalese L; Billiar T R; Rao A S; Bauer A J
Interaction between ischemia/reperfusion-induced leukocyte emigration and translocating bacterial enterotoxins on enteric muscle function.
Transplantation proceedings 1997;29(3):1815.
1997: Luss H; Li R K; Shapiro R A; Tzeng E; McGowan F X; Yoneyama T; Hatakeyama K; Geller D A; Mickle D A; Simmons R L; Billiar T R
Dedifferentiated human ventricular cardiac myocytes express inducible nitric oxide synthase mRNA but not protein in response to IL-1, TNF, IFNgamma, and LPS.
Journal of molecular and cellular cardiology 1997;29(4):1153-65.
1997: Kelly E; Shah N S; Morgan N N; Watkins S C; Peitzman A B; Billiar T R
Physiologic and molecular characterization of the role of nitric oxide in hemorrhagic shock: evidence that type II nitric oxide synthase does not regulate vascular decompensation.
Shock (Augusta, Ga.) 1997;7(3):157-63.
1997: Harbrecht B G; Di Silvio M; Chough V; Kim Y M; Simmons R L; Billiar T R
Glutathione regulates nitric oxide synthase in cultured hepatocytes.
Annals of surgery 1997;225(1):76-87.
1997: Kim Y M; de Vera M E; Watkins S C; Billiar T R
Nitric oxide protects cultured rat hepatocytes from tumor necrosis factor-alpha-induced apoptosis by inducing heat shock protein 70 expression.
The Journal of biological chemistry 1997;272(2):1402-11.
1997: Shah N S; Nakayama D K; Jacob T D; Nishio I; Imai T; Billiar T R; Exler R; Yousem S A; Motoyama E K; Peitzman A B
Efficacy of inhaled nitric oxide in oleic acid-induced acute lung injury.
Critical care medicine 1997;25(1):153-8.
1997: Hierholzer C; Kelly E; Billiar T R; Tweardy D J
Granulocyte colony-stimulating factor (G-CSF) production in hemorrhagic shock requires both the ischemic and resuscitation phase.
Archives of orthopaedic and trauma surgery 1997;116(3):173-6.
1996: Harbrecht B G; Wirant E M; Kim Y M; Billiar T R
Glucagon inhibits hepatocyte nitric oxide synthesis.
Archives of surgery (Chicago, Ill. : 1960) 1996;131(12):1266-72.
1996: Tzeng E; Shears L L; Lotze M T; Billiar T R
Gene therapy.
Current problems in surgery 1996;33(12):961-1041.
1996: de Vera M E; Kim Y M; Wong H R; Wang Q; Billiar T R; Geller D A
Heat shock response inhibits cytokine-inducible nitric oxide synthase expression in rat hepatocytes.
Hepatology (Baltimore, Md.) 1996;24(5):1238-45.
1996: Yee E L; Pitt B R; Billiar T R; Kim Y M
Effect of nitric oxide on heme metabolism in pulmonary artery endothelial cells.
The American journal of physiology 1996;271(4 Pt 1):L512-8.
1996: Ou J; Molina L; Kim Y M; Billiar T R
Excessive NO production dose not account for the inhibition of hepatic gluconeogenesis in endotoxemia.
The American journal of physiology 1996;271(4 Pt 1):G621-8.
1996: Pastor C M; Williams D; Yoneyama T; Hatakeyama K; Singleton S; Naylor E; Billiar T R
Competition for tetrahydrobiopterin between phenylalanine hydroxylase and nitric oxide synthase in rat liver.
The Journal of biological chemistry 1996;271(40):24534-8.
1996: Liu Z Z; Cui S; Billiar T R; Dorko K; Halfter W; Geller D A; Michalopoulos G; Beger H G; Albina J; Nussler A K
Effects of hepatocellular mitogens on cytokine-induced nitric oxide synthesis in human hepatocytes.
Journal of leukocyte biology 1996;60(3):382-8.
1996: Kim Y M; Hong S J; Billiar T R; Simmons R L
Counterprotective effect of erythrocytes in experimental bacterial peritonitis is due to scavenging of nitric oxide and reactive oxygen intermediates.
Infection and immunity 1996;64(8):3074-80.
1996: Kelly E; Morgan N; Woo E S; Chetlin B; Peitzman A B; Harbrecht B G; Billiar T R
Metallothionein and HSP-72 are induced in the liver by hemorrhagic shock and resuscitation but not by shock alone.
Surgery 1996;120(2):403-9; discussion 409-10.
1996: Tzeng E; Yoneyama T; Hatakeyama K; Shears L L; Billiar T R
Vascular inducible nitric oxide synthase gene therapy: requirement for guanosine triphosphate cyclohydrolase I.
Surgery 1996;120(2):315-21.
1996: de Vera M E; Wong J M; Zhou J Y; Tzeng E; Wong H R; Billiar T R; Geller D A
Cytokine-induced nitric oxide synthase gene transcription is blocked by the heat shock response in human liver cells.
Surgery 1996;120(2):144-9.
1996: Wong H R; Finder J D; Wasserloos K; Lowenstein C J; Geller D A; Billiar T R; Pitt B R; Davies P
Transcriptional regulation of iNOS by IL-1 beta in cultured rat pulmonary artery smooth muscle cells.
The American journal of physiology 1996;271(1 Pt 1):L166-71.
1996: Clark R S; Kochanek P M; Obrist W D; Wong H R; Billiar T R; Wisniewski S R; Marion D W
Cerebrospinal fluid and plasma nitrite and nitrate concentrations after head injury in humans.
Critical care medicine 1996;24(7):1243-51.
1996: Nussler A K; Liu Z Z; Hatakeyama K; Geller D A; Billiar T R; Morris S M
A cohort of supporting metabolic enzymes is coinduced with nitric oxide synthase in human tumor cell lines.
Cancer letters 1996;103(1):79-84.
1996: Tzeng E; Shears L L; Robbins P D; Pitt B R; Geller D A; Watkins S C; Simmons R L; Billiar T R
Vascular gene transfer of the human inducible nitric oxide synthase: characterization of activity and effects on myointimal hyperplasia.
Molecular medicine (Cambridge, Mass.) 1996;2(2):211-25.
1996: de Vera M E; Shapiro R A; Nussler A K; Mudgett J S; Simmons R L; Morris S M; Billiar T R; Geller D A
Transcriptional regulation of human inducible nitric oxide synthase (NOS2) gene by cytokines: initial analysis of the human NOS2 promoter.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(3):1054-9.
1995: Pastor C M; Billiar T R; Losser M R; Payen D M
Liver injury during sepsis.
Journal of critical care 1995;10(4):183-97.
1995: Pastor C M; Morris S M; Billiar T R
Sources of arginine for induced nitric oxide synthesis in the isolated perfused liver.
The American journal of physiology 1995;269(6 Pt 1):G861-6.
1995: Tzeng E; Billiar T R; Robbins P D; Loftus M; Stuehr D J
Expression of human inducible nitric oxide synthase in a tetrahydrobiopterin (H4B)-deficient cell line: H4B promotes assembly of enzyme subunits into an active dimer.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(25):11771-5.
1995: Nussler A K; Beger H G; Liu Z Z; Billiar T R
Nitric oxide, hepatocytes and inflammation.
Research in immunology 1995;146(9):671-77.
1995: de Vera M E; Geller D A; Billiar T R
Hepatic inducible nitric oxide synthase: regulation and function.
Biochemical Society transactions 1995;23(4):1008-13.
1995: Harbrecht B G; Wu B; Watkins S C; Marshall H P; Peitzman A B; Billiar T R
Inhibition of nitric oxide synthase during hemorrhagic shock increases hepatic injury.
Shock (Augusta, Ga.) 1995;4(5):332-7.
1995: Geller D A; de Vera M E; Russell D A; Shapiro R A; Nussler A K; Simmons R L; Billiar T R
A central role for IL-1 beta in the in vitro and in vivo regulation of hepatic inducible nitric oxide synthase. IL-1 beta induces hepatic nitric oxide synthesis.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(10):4890-8.
1995: Peitzman A B; Billiar T R; Harbrecht B G; Kelly E; Udekwu A O; Simmons R L
Hemorrhagic shock.
Current problems in surgery 1995;32(11):925-1002.
1995: Hattler B G; Oddis C V; Zeevi A; Luss H; Shah N; Geller D A; Billiar T R; Simmons R L; Finkel M S
Regulation of constitutive nitric oxide synthase activity by the human heart.
The American journal of cardiology 1995;76(12):957-9.
1995: Luss H; Watkins S C; Freeswick P D; Imro A K; Nussler A K; Billiar T R; Simmons R L; del Nido P J; McGowan F X
Characterization of inducible nitric oxide synthase expression in endotoxemic rat cardiac myocytes in vivo and following cytokine exposure in vitro.
Journal of molecular and cellular cardiology 1995;27(9):2015-29.
1995: Boone D C; Federle M; Billiar T R; Udekwu A O; Peitzman A B
Evolution of management of major hepatic trauma: identification of patterns of injury.
The Journal of trauma 1995;39(2):344-50.
1995: Wan Y; Freeswick P D; Khemlani L S; Kispert P H; Wang S C; Su G L; Billiar T R
Role of lipopolysaccharide (LPS), interleukin-1, interleukin-6, tumor necrosis factor, and dexamethasone in regulation of LPS-binding protein expression in normal hepatocytes and hepatocytes from LPS-treated rats.
Infection and immunity 1995;63(7):2435-42.
1995: Harbrecht B G; McClure E A; Simmons R L; Billiar T R
Prostanoids inhibit Kupffer cell nitric oxide synthesis.
The Journal of surgical research 1995;58(6):625-9.
1995: Nussler A K; Di Silvio M; Liu Z Z; Geller D A; Freeswick P; Dorko K; Bartoli F; Billiar T R
Further characterization and comparison of inducible nitric oxide synthase in mouse, rat, and human hepatocytes.
Hepatology (Baltimore, Md.) 1995;21(6):1552-60.
1995: Kelly E; Morris S M; Billiar T R
Nitric oxide, sepsis, and arginine metabolism.
JPEN. Journal of parenteral and enteral nutrition 1995;19(3):234-8.
1995: Schwarz M A; Lazo J S; Yalowich J C; Allen W P; Whitmore M; Bergonia H A; Tzeng E; Billiar T R; Robbins P D; Lancaster J R
Metallothionein protects against the cytotoxic and DNA-damaging effects of nitric oxide.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(10):4452-6.
1995: Wong H R; Pitt B R; Su G L; Rossignol D P; Steve A R; Billiar T R; Wang S C
Induction of lipopolysaccharide-binding protein gene expression in cultured rat pulmonary artery smooth muscle cells by interleukin 1 beta.
American journal of respiratory cell and molecular biology 1995;12(4):449-54.
1995: Billiar T R
Nitric oxide. Novel biology with clinical relevance.
Annals of surgery 1995;221(4):339-49.
1995: Harbrecht B G; Wang S C; Simmons R L; Billiar T R
Cyclic GMP and guanylate cyclase mediate lipopolysaccharide-induced Kupffer cell tumor necrosis factor-alpha synthesis.
Journal of leukocyte biology 1995;57(2):297-302.
1995: Harbrecht B G; Billiar T R
The role of nitric oxide in Kupffer cell-hepatocyte interactions.
Shock (Augusta, Ga.) 1995;3(2):79-87.
1995: Pastor C M; Billiar T R
Regulation and functions of nitric oxide in the liver in sepsis and inflammation.
New horizons (Baltimore, Md.) 1995;3(1):65-72.
1995: Pastor C M; Billiar T R
Nitric oxide causes hyporeactivity to phenylephrine in isolated perfused livers from endotoxin-treated rats.
The American journal of physiology 1995;268(1 Pt 1):G177-82.
1995: Wong J M; Billiar T R
Regulation and function of inducible nitric oxide synthase during sepsis and acute inflammation.
Advances in pharmacology (San Diego, Calif.) 1995;34():155-70.
1994: Mueller A R; Platz K P; Langrehr J M; Hoffman R A; Nussler A K; Nalesnik M; Billiar T R; Schraut W H
The effects of administration of nitric oxide inhibitors during small bowel preservation and reperfusion.
Transplantation 1994;58(12):1309-16.
1994: Harbrecht B G; Di Silvio M; Demetris A J; Simmons R L; Billiar T R
Tumor necrosis factor-alpha regulates in vivo nitric oxide synthesis and induces liver injury during endotoxemia.
Hepatology (Baltimore, Md.) 1994;20(4 Pt 1):1055-60.
1994: Luss H; DiSilvio M; Litton A L; Molina y Vedia L; Nussler A K; Billiar T R
Inhibition of nitric oxide synthesis enhances the expression of inducible nitric oxide synthase mRNA and protein in a model of chronic liver inflammation.
Biochemical and biophysical research communications 1994;204(2):635-40.
1994: Mellouk S; Hoffman S L; Liu Z Z; de la Vega P; Billiar T R; Nussler A K
Nitric oxide-mediated antiplasmodial activity in human and murine hepatocytes induced by gamma interferon and the parasite itself: enhancement by exogenous tetrahydrobiopterin.
Infection and immunity 1994;62(9):4043-6.
1994: Shah N; Jacob T; Exler R; Morrow S; Ford H; Albanese C; Wiener E; Rowe M; Billiar T; Simmons R
Inhaled nitric oxide in congenital diaphragmatic hernia.
Journal of pediatric surgery 1994;29(8):1010-4; discussion 1014-5.
1994: Nussler A K; Liu Z Z; Di Silvio M; Sweetland M A; Geller D A; Lancaster J R; Billiar T R; Freeswick P D; Lowenstein C L; Simmons R L
Hepatocyte inducible nitric oxide synthesis is influenced in vitro by cell density.
The American journal of physiology 1994;267(2 Pt 1):C394-401.
1994: Freeswick P D; Wan Y; Geller D A; Nussler A K; Billiar T R
Remote tissue injury primes hepatocytes for nitric oxide synthesis.
The Journal of surgical research 1994;57(1):205-9.
1994: Su G L; Freeswick P D; Geller D A; Wang Q; Shapiro R A; Wan Y H; Billiar T R; Tweardy D J; Simmons R L; Wang S C
Molecular cloning, characterization, and tissue distribution of rat lipopolysaccharide binding protein. Evidence for extrahepatic expression.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(2):743-52.
1994: Harbrecht B G; Stadler J; Demetris A J; Simmons R L; Billiar T R
Nitric oxide and prostaglandins interact to prevent hepatic damage during murine endotoxemia.
The American journal of physiology 1994;266(6 Pt 1):G1004-10.
1994: Morris S M; Billiar T R
New insights into the regulation of inducible nitric oxide synthesis.
The American journal of physiology 1994;266(6 Pt 1):E829-39.
1994: Hattler B G; Gorcsan J; Shah N; Oddis C V; Billiar T R; Simmons R L; Finkel M S
A potential role for nitric oxide in myocardial stunning.
Journal of cardiac surgery 1994;9(3 Suppl):425-9.
1994: Jacob T D; Nakayama D K; Seki I; Exler R; Lancaster J R; Sweetland M A; Yousem S; Simmons R L; Billiar T R; Peitzman A B
Hemodynamic effects and metabolic fate of inhaled nitric oxide in hypoxic piglets.
Journal of applied physiology (Bethesda, Md. : 1985) 1994;76(4):1794-801.
1994: Chartrain N A; Geller D A; Koty P P; Sitrin N F; Nussler A K; Hoffman E P; Billiar T R; Hutchinson N I; Mudgett J S
Molecular cloning, structure, and chromosomal localization of the human inducible nitric oxide synthase gene.
The Journal of biological chemistry 1994;269(9):6765-72.
1994: Shah N S; Nakayama D K; Jacob T D; Nishio I; Imai T; Billiar T R; Exler R; Yousem S A; Motoyama E K; Peitzman A B
Efficacy of inhaled nitric oxide in a porcine model of adult respiratory distress syndrome.
Archives of surgery (Chicago, Ill. : 1960) 1994;129(2):158-64.
1994: Geller D A; Freeswick P D; Nguyen D; Nussler A K; Di Silvio M; Shapiro R A; Wang S C; Simmons R L; Billiar T R
Differential induction of nitric oxide synthase in hepatocytes during endotoxemia and the acute-phase response.
Archives of surgery (Chicago, Ill. : 1960) 1994;129(2):165-71.
1994: Nussler A K; Billiar T R; Liu Z Z; Morris S M
Coinduction of nitric oxide synthase and argininosuccinate synthetase in a murine macrophage cell line. Implications for regulation of nitric oxide production.
The Journal of biological chemistry 1994;269(2):1257-61.
1993: Geller D A; Billiar T R
Should surgeons clone genes? The strategy behind the cloning of the human inducible nitric oxide synthase gene.
Archives of surgery (Chicago, Ill. : 1960) 1993;128(11):1212-20.
1993: Jacob T D; Ochoa J B; Udekwu A O; Wilkinson J; Murray T; Billiar T R; Simmons R L; Marion D W; Peitzman A B
Nitric oxide production is inhibited in trauma patients.
The Journal of trauma 1993;35(4):590-6; discussion 596-7.
1993: Geller D A; Di Silvio M; Nussler A K; Wang S C; Shapiro R A; Simmons R L; Billiar T R
Nitric oxide synthase expression is induced in hepatocytes in vivo during hepatic inflammation.
The Journal of surgical research 1993;55(4):427-32.
1993: Harbrecht B G; Billiar T R; Curran R D; Stadler J; Simmons R L
Hepatocyte injury by activated neutrophils in vitro is mediated by proteases.
Annals of surgery 1993;218(2):120-8.
1993: Nussler A K; Billiar T R
Inflammation, immunoregulation, and inducible nitric oxide synthase.
Journal of leukocyte biology 1993;54(2):171-8.
1993: Geller D A; Nguyen D; Shapiro R A; Nussler A; Di Silvio M; Freeswick P; Wang S C; Tweardy D J; Simmons R L; Billiar T R
Cytokine induction of interferon regulatory factor-1 in hepatocytes.
Surgery 1993;114(2):235-42.
1993: Nüssler A K; Geller D A; Sweetland M A; Di Silvio M; Billiar T R; Madariaga J B; Simmons R L; Lancaster J R
Induction of nitric oxide synthesis and its reactions in cultured human and rat hepatocytes stimulated with cytokines plus LPS.
Biochemical and biophysical research communications 1993;194(2):826-35.
1993: Stadler J; Bergonia H A; Di Silvio M; Sweetland M A; Billiar T R; Simmons R L; Lancaster J R
Nonheme iron-nitrosyl complex formation in rat hepatocytes: detection by electron paramagnetic resonance spectroscopy.
Archives of biochemistry and biophysics 1993;302(1):4-11.
1993: Geller D A; Lowenstein C J; Shapiro R A; Nussler A K; Di Silvio M; Wang S C; Nakayama D K; Simmons R L; Snyder S H; Billiar T R
Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(8):3491-5.
1993: Stadler J; Harbrecht B G; Di Silvio M; Curran R D; Jordan M L; Simmons R L; Billiar T R
Endogenous nitric oxide inhibits the synthesis of cyclooxygenase products and interleukin-6 by rat Kupffer cells.
Journal of leukocyte biology 1993;53(2):165-72.
1993: Geller D A; Kispert P H; Su G L; Wang S C; Di Silvio M; Tweardy D J; Billiar T R; Simmons R L
Induction of hepatocyte lipopolysaccharide binding protein in models of sepsis and the acute-phase response.
Archives of surgery (Chicago, Ill. : 1960) 1993;128(1):22-7; discussion 27-8.
1993: Geller D A; Nussler A K; Di Silvio M; Lowenstein C J; Shapiro R A; Wang S C; Simmons R L; Billiar T R
Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(2):522-6.
1993: Di Silvio M; Geller D A; Gross S S; Nussler A; Freeswick P; Simmons R L; Billiar T R
Inducible nitric oxide synthase activity in hepatocytes is dependent on the coinduction of tetrahydrobiopterin synthesis.
Advances in experimental medicine and biology 1993;338():305-8.
1992: Stadler J; Bentz B G; Harbrecht B G; Di Silvio M; Curran R D; Billiar T R; Hoffman R A; Simmons R L
Tumor necrosis factor alpha inhibits hepatocyte mitochondrial respiration.
Annals of surgery 1992;216(5):539-46.
1992: Harbrecht B G; Billiar T R; Stadler J; Demetris A J; Ochoa J B; Curran R D; Simmons R L
Nitric oxide synthesis serves to reduce hepatic damage during acute murine endotoxemia.
Critical care medicine 1992;20(11):1568-74.
1992: Nakayama D K; Geller D A; Lowenstein C J; Chern H D; Davies P; Pitt B R; Simmons R L; Billiar T R
Cytokines and lipopolysaccharide induce nitric oxide synthase in cultured rat pulmonary artery smooth muscle.
American journal of respiratory cell and molecular biology 1992;7(5):471-6.
1992: Harbrecht B G; Billiar T R; Stadler J; Demetris A J; Ochoa J; Curran R D; Simmons R L
Inhibition of nitric oxide synthesis during endotoxemia promotes intrahepatic thrombosis and an oxygen radical-mediated hepatic injury.
Journal of leukocyte biology 1992;52(4):390-4.
1992: Nussler A K; Di Silvio M; Billiar T R; Hoffman R A; Geller D A; Selby R; Madariaga J; Simmons R L
Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin.
The Journal of experimental medicine 1992;176(1):261-4.
1992: Ochoa J B; Curti B; Peitzman A B; Simmons R L; Billiar T R; Hoffman R; Rault R; Longo D L; Urba W J; Ochoa A C
Increased circulating nitrogen oxides after human tumor immunotherapy: correlation with toxic hemodynamic changes.
Journal of the National Cancer Institute 1992;84(11):864-7.
1992: Wren S M; Hoffman R A; Billiar T R; Abou el Ezz A; Hronakes M L; Ildstad S T
T-cell mitogenic responses in fully xenogeneic chimeras (WF rat----B10 mouse) are restored by blocking the L-arginine-dependent nitric oxide pathway.
Transplantation proceedings 1992;24(2):499-500.
1992: Billiar T R; Curran R D; Harbrecht B G; Stadler J; Williams D L; Ochoa J B; Di Silvio M; Simmons R L; Murray S A
Association between synthesis and release of cGMP and nitric oxide biosynthesis by hepatocytes.
The American journal of physiology 1992;262(4 Pt 1):C1077-82.
1992: Langrehr J M; Dull K E; Ochoa J B; Billiar T R; Ildstad S T; Schraut W H; Simmons R L; Hoffman R A
Evidence that nitric oxide production by in vivo allosensitized cells inhibits the development of allospecific CTL.
Transplantation 1992;53(3):632-40.
1992: Billiar T R; Curran R D; Williams D L; Kispert P H
Liver nonparenchymal cells are stimulated to provide interleukin 6 for induction of the hepatic acute-phase response in endotoxemia but not in remote localized inflammation.
Archives of surgery (Chicago, Ill. : 1960) 1992;127(1):31-6; discussion 36-7.
1991: Stadler J; Stefanovic-Racic M; Billiar T R; Curran R D; McIntyre L A; Georgescu H I; Simmons R L; Evans C H
Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharide.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(11):3915-20.
1991: Ochoa J B; Udekwu A O; Billiar T R; Curran R D; Cerra F B; Simmons R L; Peitzman A B
Nitrogen oxide levels in patients after trauma and during sepsis.
Annals of surgery 1991;214(5):621-6.
1991: Bentz M L; Sheppeck R A; Macpherson T; Garrett K O; Billiar T; Dickson C S; Janosky J; Johnson P C
Vasospasm and platelet deposition in human arteries: effects of topical methylene blue.
Plastic and reconstructive surgery 1991;88(5):851-9.
1991: Billiar T R; Langrehr J M; Curran R D; Ochoa J B; Stadler J; Harbrecht B G; Hoffman R A; Simmons R L
Two unique aspects of inducible .N = O synthase in liver cells and accessory cells: hepatic damage is minimized by hepatocyte .N = O production and immunoregulation is mediated by macrophage .N = O production.
Research in immunology 1991;142(7):584-6; discussion 598-9.
1991: Langrehr J M; Hoffman R A; Billiar T R; Lee K K; Schraut W H; Simmons R L
Nitric oxide synthesis in the in vivo allograft response: a possible regulatory mechanism.
Surgery 1991;110(2):335-42.
1991: Stadler J; Billiar T R; Curran R D; Stuehr D J; Ochoa J B; Simmons R L
Effect of exogenous and endogenous nitric oxide on mitochondrial respiration of rat hepatocytes.
The American journal of physiology 1991;260(5 Pt 1):C910-6.
1991: Curran R D; Ferrari F K; Kispert P H; Stadler J; Stuehr D J; Simmons R L; Billiar T R
Nitric oxide and nitric oxide-generating compounds inhibit hepatocyte protein synthesis.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1991;5(7):2085-92.
1991: Langrehr J M; Hoffman R A; Billiar T R; Lee K W; Schraut W H; Simmons R L
Nitric oxide production regulates alloactivation in rat splenocyte mixed lymphocyte cultures.
Transplantation proceedings 1991;23(1 Pt 1):183-4.
1991: Stadler J; Curran R D; Ochoa J B; Harbrecht B G; Hoffman R A; Simmons R L; Billiar T R
Effect of endogenous nitric oxide on mitochondrial respiration of rat hepatocytes in vitro and in vivo.
Archives of surgery (Chicago, Ill. : 1960) 1991;126(2):186-91.
1991: Langrehr J M; Hoffman R A; Lee K W; Billiar T R; Schraut W H; Simmons R L
Sponge allograft effector cells exert suppressor function via an L-arginine-dependent mechanism.
Transplantation proceedings 1991;23(1 Pt 1):839-40.
1990: Billiar T R; Curran R D; Harbrecht B G; Stuehr D J; Demetris A J; Simmons R L
Modulation of nitrogen oxide synthesis in vivo: NG-monomethyl-L-arginine inhibits endotoxin-induced nitrate/nitrate biosynthesis while promoting hepatic damage.
Journal of leukocyte biology 1990;48(6):565-9.
1990: Hoffman R A; Langrehr J M; Billiar T R; Curran R D; Simmons R L
Alloantigen-induced activation of rat splenocytes is regulated by the oxidative metabolism of L-arginine.
Journal of immunology (Baltimore, Md. : 1950) 1990;145(7):2220-6.
1990: Curran R D; Billiar T R; Stuehr D J; Ochoa J B; Harbrecht B G; Flint S G; Simmons R L
Multiple cytokines are required to induce hepatocyte nitric oxide production and inhibit total protein synthesis.
Annals of surgery 1990;212(4):462-9; discussion 470-1.
1990: Billiar T R; Curran R D
Kupffer cell and hepatocyte interactions: a brief overview.
JPEN. Journal of parenteral and enteral nutrition 1990;14(5 Suppl):175S-180S.
1990: Billiar T R; Curran R D; Stuehr D J; Stadler J; Simmons R L; Murray S A
Inducible cytosolic enzyme activity for the production of nitrogen oxides from L-arginine in hepatocytes.
Biochemical and biophysical research communications 1990;168(3):1034-40.
1990: Billiar T R; Curran R D; Ferrari F K; Williams D L; Simmons R L
Kupffer cell:hepatocyte cocultures release nitric oxide in response to bacterial endotoxin.
The Journal of surgical research 1990;48(4):349-53.
1990: Billiar T R; Lysz T W; Curran R D; Bentz B G; Machiedo G W; Simmons R L
Hepatocyte modulation of Kupffer cell prostaglandin E2 production in vitro.
Journal of leukocyte biology 1990;47(4):305-11.
1989: Billiar T R; Curran R D; West M A; Hofmann K; Simmons R L
Kupffer cell cytotoxicity to hepatocytes in coculture requires L-arginine.
Archives of surgery (Chicago, Ill. : 1960) 1989;124(12):1416-20; discussion 1420-1.
1989: Kaplan S S; Billiar T; Curran R D; Zdziarski U E; Simmons R L; Basford R E
Inhibition of chemotaxis Ng-monomethyl-L-arginine: a role for cyclic GMP.
Blood 1989;74(6):1885-7.
1989: Curran R D; Billiar T R; Stuehr D J; Hofmann K; Simmons R L
Hepatocytes produce nitrogen oxides from L-arginine in response to inflammatory products of Kupffer cells.
The Journal of experimental medicine 1989;170(5):1769-74.
1989: Billiar T R; Curran R D; Stuehr D J; Ferrari F K; Simmons R L
Evidence that activation of Kupffer cells results in production of L-arginine metabolites that release cell-associated iron and inhibit hepatocyte protein synthesis.
Surgery 1989;106(2):364-71; discussion 371-2.
1989: Curran R D; Billiar T R; Kispert P H; Bentz B G; May M T; Simmons R L
Hepatocytes enhance Kupffer cell-mediated tumor cell cytostasis in vitro.
Surgery 1989;106(2):126-32.
1989: West M A; Billiar T R; Curran R D; Hyland B J; Simmons R L
Evidence that rat Kupffer cells stimulate and inhibit hepatocyte protein synthesis in vitro by different mechanisms.
Gastroenterology 1989;96(6):1572-82.
1989: Bankey P E; Billiar T R; Wang W Y; Carlson A; Holman R T; Cerra F B
Modulation of Kupffer cell membrane phospholipid function by n-3 polyunsaturated fatty acids.
The Journal of surgical research 1989;46(5):439-44.
1989: Billiar T R; Curran R D; Stuehr D J; West M A; Bentz B G; Simmons R L
An L-arginine-dependent mechanism mediates Kupffer cell inhibition of hepatocyte protein synthesis in vitro.
The Journal of experimental medicine 1989;169(4):1467-72.
1989: Bumgardner G L; Billiar T; So S K; Chen S; Dunn G; Payne W; Ascher N L
In vitro immunosuppressive effects of murine hepatocyte cytosol.
Transplantation proceedings 1989;21(1 Pt 1):1154-5.
1989: Cerra F B; West M; Billiar T R; Holman R T; Simmons R
Hepatic dysfunction in multiple systems organ failure as a manifestation of altered cell-cell interaction.
Progress in clinical and biological research 1989;308():563-73.
1989: Cerra F B; Mazuski J E; Bankey P E; Billiar T R; Holman R T
Role of monokines in altering hepatic metabolism in sepsis.
Progress in clinical and biological research 1989;286():265-77.
1988: West M A; Billiar T R; Mazuski J E; Curran R J; Cerra F B; Simmons R L
Endotoxin modulation of hepatocyte secretory and cellular protein synthesis is mediated by Kupffer cells.
Archives of surgery (Chicago, Ill. : 1960) 1988;123(11):1400-5.
1988: Curran R D; Billiar T R; West M A; Bentz B G; Simmons R L
Effect of interleukin 2 on Kupffer cell activation. Interleukin 2 primes and activates Kupffer cells to suppress hepatocyte protein synthesis in vitro.
Archives of surgery (Chicago, Ill. : 1960) 1988;123(11):1373-8.
1988: Cerra F B; Alden P A; Negro F; Billiar T; Svingen B A; Licari J; Johnson S B; Holman R T
Sepsis and exogenous lipid modulation.
JPEN. Journal of parenteral and enteral nutrition 1988;12(6 Suppl):63S-68S.
1988: Billiar T R; Maddaus M A; West M A; Curran R D; Wells C A; Simmons R L
Intestinal gram-negative bacterial overgrowth in vivo augments the in vitro response of Kupffer cells to endotoxin.
Annals of surgery 1988;208(4):532-40.
1988: Billiar T R; Bankey P E; Svingen B A; Curran R D; West M A; Holman R T; Simmons R L; Cerra F B
Fatty acid intake and Kupffer cell function: fish oil alters eicosanoid and monokine production to endotoxin stimulation.
Surgery 1988;104(2):343-9.
1988: Billiar T R; Hanto D W; Simmons R L
Inclusion of uncomplicated infectious mononucleosis in the spectrum of Epstein-Barr virus infections in transplant recipients.
Transplantation 1988;46(1):159-61.
1988: Billiar T R; Maddaus M A; West M A; Dunn D L; Simmons R L
The role of intestinal flora on the interactions between nonparenchymal cells and hepatocytes in coculture.
The Journal of surgical research 1988;44(4):397-403.
1988: Billiar T R; West M A; Hyland B J; Simmons R L
Splenectomy alters Kupffer cell response to endotoxin.
Archives of surgery (Chicago, Ill. : 1960) 1988;123(3):327-32.
1988: Billiar T R; West M A; Hyland B J; Cerra F B; Simmons R L; Dunn D L
Murine monoclonal antibody directed against lipopolysaccharide (LPS) inhibits Kupffer cell activation by endotoxin in vitro.
Progress in clinical and biological research 1988;264():367-72.
1987: West M A; Billiar T R; Hyland B J; Jordan M L; Simmons R L
Regulation of Kupffer cell-mediated alterations in hepatocyte protein synthesis in vitro.
Current surgery 1987;44(6):467-9.

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