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Ranabir Sinha Roy

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Changyou Zhou; Margareta Garcia-Calvo; Shirly Pinto; Matthew Lombardo; Zhe Feng; Kate Bender; KellyAnn D Pryor; Urmi R Bhatt; Renee M Chabin; Wayne M Geissler; Zhu Shen; Xinchun Tong; Zhoupeng Zhang; Kenny K Wong; Ranabir Sinha Roy; Kevin Chapman; Lihu Yang; Yusheng Xiong
Design and synthesis of prolylcarboxypeptidase (PrCP) inhibitors to validate PrCP as a potential target for obesity.
James Mu; Aleksandr Petrov; George J Eiermann; John Woods; Yun-Ping Zhou; Zhihua Li; Emanuel Zycband; Yue Feng; Lan Zhu; Ranabir Sinha Roy; Andrew D Howard; Cai Li; Nancy A Thornberry; Bei B Zhang
Inhibition of DPP-4 with sitagliptin improves glycemic control and restores islet cell mass and function in a rodent model of type 2 diabetes.
Scott D Edmondson; Anthony Mastracchio; Jason M. Cox; George J Eiermann; Huaibing He; Kathryn A Lyons; Reshma A Patel; Sangita B Patel; Aleksandr Petrov; Giovanna Scapin; Joseph K Wu; Shiyao Xu; Bing Zhu; Nancy A Thornberry; Ranabir Sinha Roy; Ann E Weber
Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors.

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All Publications

2010: Changyou Zhou; Margareta Garcia-Calvo; Shirly Pinto; Matthew Lombardo; Zhe Feng; Kate Bender; KellyAnn D Pryor; Urmi R Bhatt; Renee M Chabin; Wayne M Geissler; Zhu Shen; Xinchun Tong; Zhoupeng Zhang; Kenny K Wong; Ranabir Sinha Roy; Kevin Chapman; Lihu Yang; Yusheng Xiong
Design and synthesis of prolylcarboxypeptidase (PrCP) inhibitors to validate PrCP as a potential target for obesity.
Journal of medicinal chemistry 2010;53(19):7251-63.
2009: James Mu; Aleksandr Petrov; George J Eiermann; John Woods; Yun-Ping Zhou; Zhihua Li; Emanuel Zycband; Yue Feng; Lan Zhu; Ranabir Sinha Roy; Andrew D Howard; Cai Li; Nancy A Thornberry; Bei B Zhang
Inhibition of DPP-4 with sitagliptin improves glycemic control and restores islet cell mass and function in a rodent model of type 2 diabetes.
European journal of pharmacology 2009;623(1-3):148-54.
2009: Scott D Edmondson; Anthony Mastracchio; Jason M. Cox; George J Eiermann; Huaibing He; Kathryn A Lyons; Reshma A Patel; Sangita B Patel; Aleksandr Petrov; Giovanna Scapin; Joseph K Wu; Shiyao Xu; Bing Zhu; Nancy A Thornberry; Ranabir Sinha Roy; Ann E Weber
Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(15):4097-101.
2008: Dooseop Kim; Jennifer E Kowalchick; Linda L Brockunier; Emma R Parmee; George J Eiermann; Michael H Fisher; Huaibing He; Barbara Leiting; Kathryn Lyons; Giovanna Scapin; Sangita B Patel; Aleksandr Petrov; KellyAnn D Pryor; Ranabir Sinha Roy; Joseph K Wu; Xiaoping Zhang; Matthew J Wyvratt; Bei B Zhang; Lan Zhu; Nancy A Thornberry; Ann E Weber
Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from beta-aminoamides bearing subsituted triazolopiperazines.
Journal of medicinal chemistry 2008;51(3):589-602.
2007: Stacey L Conarello; Guoqiang Jiang; J Mu; Zhihua Li; John Woods; Emanuel Zycband; John Ronan; Franklin Liu; Ranabir Sinha Roy; Lan Zhu; Maureen J Charron; Bei B Zhang
Glucagon receptor knockout mice are resistant to diet-induced obesity and streptozotocin-mediated beta cell loss and hyperglycaemia.
Diabetologia 2007;50(1):142-50.
2006: Scott D Edmondson; Anthony Mastracchio; Robert J Mathvink; Jiafang He; Bart Harper; You-Jung Park; Maria G Beconi; Jerry Di Salvo; George J Eiermann; Huaibing He; Barbara Leiting; Joseph F Leone; Dorothy A Levorse; Kathryn Lyons; Reshma A Patel; Sangita B Patel; Aleksandr Petrov; Giovanna Scapin; Jackie Shang; Ranabir Sinha Roy; Aaron Smith; Joseph K Wu; Shiyao Xu; Bing Zhu; Nancy A Thornberry; Ann E Weber
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]-pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Journal of medicinal chemistry 2006;49(12):3614-27.
2006: James Mu; John Woods; Yun-Ping Zhou; Ranabir Sinha Roy; Zhihua Li; Emanuel Zycband; Yue Feng; Lan Zhu; Cai Li; Andrew D Howard; David E Moller; Nancy A Thornberry; Bei B Zhang
Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes.
Diabetes 2006;55(6):1695-704.
2005: George R Lankas; Barbara Leiting; Ranabir Sinha Roy; George J Eiermann; Maria G Beconi; Szalkowski Deborah; Chi-Chung Chan; Scott D Edmondson; William P Feeney; Huaibing He; Dawn E Ippolito; Dooseop Kim; Kathryn A Lyons; Hyun O Ok; Reshma A Patel; Aleksandr N Petrov; Kelly Ann Pryor; Xiaoxia Qian; Leah Reigle; Andrea Woods; Joseph K Wu; Dennis Zaller; Xiaoping Zhang; Lan Zhu; Ann E Weber; Nancy A Thornberry
Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9.
Diabetes 2005;54(10):2988-94.
2005: Dooseop Kim; Liping Wang; Maria G Beconi; George J Eiermann; Michael H Fisher; Huaibing He; Gerard J Hickey; Jennifer E Kowalchick; Barbara Leiting; Kathryn Lyons; Frank Marsilio; Margaret E McCann; Reshma A Patel; Aleksandr Petrov; Giovanna Scapin; Sangita B Patel; Ranabir Sinha Roy; Joseph K Wu; Matthew J Wyvratt; Bei B Zhang; Lan Zhu; Nancy A Thornberry; Ann E Weber
(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Journal of medicinal chemistry 2005;48(1):141-51.
2003: Stacey L Conarello; Zhihua Li; John Ronan; Ranabir Sinha Roy; Lan Zhu; Guoqiang Jiang; Franklin Liu; John Woods; Emanuel Zycband; David E Moller; Nancy A Thornberry; Bei B Zhang
Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(11):6825-30.