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Rima Rozen

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Leonie G Mikael; Jill Pancer; Marie Caudill; Xinyin Jiang; Qing Wu; Rima Rozen
Low dietary folate and methylenetetrahydrofolate reductase deficiency may lead to pregnancy complications through modulation of ApoAI and IFN-γ in spleen and placenta, and through reduction of methylation potential.
Daniel Leclerc; Leonie G Mikael; Yuanhang Cao; Liyuan Deng; Qing Wu; Rima Rozen
Differential gene expression and methylation in the retinoid/PPARA pathway and of tumor suppressors may modify intestinal tumorigenesis induced by low folate in mice.
Leonie G Mikael; Ligi Paul; Liyuan Deng; Jacob Selhub; Rima Rozen
Moderately high intake of folic acid has a negative impact on mouse embryonic development.

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2013: Leonie G Mikael; Jill Pancer; Marie Caudill; Xinyin Jiang; Qing Wu; Rima Rozen
Low dietary folate and methylenetetrahydrofolate reductase deficiency may lead to pregnancy complications through modulation of ApoAI and IFN-γ in spleen and placenta, and through reduction of methylation potential.
Molecular nutrition & food research 2013;57(4):661-70.
2013: Daniel Leclerc; Leonie G Mikael; Yuanhang Cao; Liyuan Deng; Qing Wu; Rima Rozen
Differential gene expression and methylation in the retinoid/PPARA pathway and of tumor suppressors may modify intestinal tumorigenesis induced by low folate in mice.
Molecular nutrition & food research 2013;57(4):686-97.
2013: Leonie G Mikael; Ligi Paul; Liyuan Deng; Jacob Selhub; Rima Rozen
Moderately high intake of folic acid has a negative impact on mouse embryonic development.
Birth defects research. Part A, Clinical and molecular teratology 2013;97(1):47-52.
2012: Aabida Saferali; Jacquetta Trasler; Rima Rozen; Donovan Chan; Taiping Chen; Sanny Moussette; Anna K Naumova
DNA methyltransferase 1 (Dnmt1) mutation affects Snrpn imprinting in the mouse male germ line.
Genome / National Research Council Canada = Génome / Conseil national de recherches Canada 2012;55(9):673-82.
2012: Nafisa M Jadavji; Daniel Leclerc; Olga Malysheva; Barry J Bedell; Marie A Caudill; Liyuan Deng; Rima Rozen
Severe methylenetetrahydrofolate reductase deficiency in mice results in behavioral anomalies with morphological and biochemical changes in hippocampus.
Molecular genetics and metabolism 2012;106(2):149-59.
2012: Leonie G Mikael; Jill Pancer; Qing Wu; Rima Rozen
Disturbed one-carbon metabolism causing adverse reproductive outcomes in mice is associated with altered expression of apolipoprotein AI and inflammatory mediators PPARα, interferon-γ, and interleukin-10.
The Journal of nutrition 2012;142(3):411-8.
2011: Laura Pickell; Hana Friedman; Daniel Leclerc; Alan C Peterson; Xiao-Ling Wang; Qing Wu; Rima Rozen
Targeted insertion of two Mthfr promoters in mice reveals temporal- and tissue-specific regulation.
Mammalian genome : official journal of the International Mammalian Genome Society 2011;22(11-12):635-47.
2011: Erin Knock; Warren Kruger; Natalia I Krupenko; Daniel Leclerc; Ryan D Mohan; Liyuan Deng; C Lee Elmore; Sapna Gupta; Marc Tini; Qing Wu; Rima Rozen
Susceptibility to intestinal tumorigenesis in folate-deficient mice may be influenced by variation in one-carbon metabolism and DNA repair.
The Journal of nutritional biochemistry 2011;22(11):1022-9.
2011: Andrea K Lawrance; Julie Racine; Liyuan Deng; Xiaoling Wang; Pierre Lachapelle; Rima Rozen
Complete deficiency of methylenetetrahydrofolate reductase in mice is associated with impaired retinal function and variable mortality, hematological profiles, and reproductive outcomes.
Journal of inherited metabolic disease 2011;34(1):147-57.
2011: Laura Pickell; Katharine Brown; Deqiang Li; Xiao-Ling Wang; Liyuan Deng; Qing Wu; Jacob Selhub; Li Luo; Loydie Jerome-Majewska; Rima Rozen
High intake of folic acid disrupts embryonic development in mice.
Birth defects research. Part A, Clinical and molecular teratology 2011;91(1):8-19.
2010: Karen E Christensen; Qing Wu; Xiaoling Wang; Liyuan Deng; Marie A Caudill; Rima Rozen
Steatosis in mice is associated with gender, folate intake, and expression of genes of one-carbon metabolism.
The Journal of nutrition 2010;140(10):1736-41.
2010: Donovan Chan; Duncan W Cushnie; Oana R Neaga; Andrea K Lawrance; Rima Rozen; Jacquetta M Trasler
Strain-specific defects in testicular development and sperm epigenetic patterns in 5,10-methylenetetrahydrofolate reductase-deficient mice.
Endocrinology 2010;151(7):3363-73.
2010: Jessica Chan; Liyuan Deng; Leonie G Mikael; Jian Yan; Laura Pickell; Qing Wu; Marie A Caudill; Rima Rozen
Low dietary choline and low dietary riboflavin during pregnancy influence reproductive outcomes and heart development in mice.
The American journal of clinical nutrition 2010;91(4):1035-43.
2009: Basak Celtikci; Andrea K Lawrance; Qing Wu; Rima Rozen
Methotrexate-induced apoptosis is enhanced by altered expression of methylenetetrahydrofolate reductase.
Anti-cancer drugs 2009;20(9):787-93.
2009: Michael S Kramer; Susan R Kahn; Robert W Platt; Jacques Genest; Rima Rozen; Moy Fong Chen; Lise Goulet; Louise Séguin; Clément Dassa; John Lydon; Helen McNamara; Mourad Dahhou; Julie Lamoureux; Rhobert W Evans
Antioxidant vitamins, long-chain fatty acids, and spontaneous preterm birth.
Epidemiology (Cambridge, Mass.) 2009;20(5):707-13.
2009: Leonie G Mikael; Xiao-Ling Wang; Qing Wu; Hua Jiang; Kenneth N Maclean; Rima Rozen
Hyperhomocysteinemia is associated with hypertriglyceridemia in mice with methylenetetrahydrofolate reductase deficiency.
Molecular genetics and metabolism 2009;98(1-2):187-94.
2009: Michael S Kramer; Susan R Kahn; Rima Rozen; Rhobert Evans; Robert W Platt; Moy Fong Chen; Lise Goulet; Louise Séguin; Clément Dassa; John Lydon; Helen McNamara; Mourad Dahhou; Jacques Genest
Vasculopathic and thrombophilic risk factors for spontaneous preterm birth.
International journal of epidemiology 2009;38(3):715-23.
2009: Laura Pickell; Deqiang Li; Katharine Brown; Leonie G Mikael; Xiao-Ling Wang; Qing Wu; Li Luo; Loydie Jerome-Majewska; Rima Rozen
Methylenetetrahydrofolate reductase deficiency and low dietary folate increase embryonic delay and placental abnormalities in mice.
Birth defects research. Part A, Clinical and molecular teratology 2009;85(6):531-41.
2009: David Garcia-Crespo; Erin Knock; Nada Jabado; Rima Rozen
Intestinal neoplasia induced by low dietary folate is associated with altered tumor expression profiles and decreased apoptosis in mouse normal intestine.
The Journal of nutrition 2009;139(3):488-94.
2009: Susan R Kahn; Robert Platt; Helen McNamara; Rima Rozen; Moy Fong Chen; Jacques Genest; Lise Goulet; John Lydon; Louise Seguin; Clément Dassa; André Masse; Guylaine Asselin; Alice Benjamin; Louise Miner; Antoinette Ghanem; Michael S Kramer
Inherited thrombophilia and preeclampsia within a multicenter cohort: the Montreal Preeclampsia Study.
American journal of obstetrics and gynecology 2009;200(2):151.e1-9; discussion e1-5.
2008: Marc Roy; Daniel Leclerc; Qing Wu; Sapna Gupta; warren kruger; Rima Rozen
Valproic acid increases expression of methylenetetrahydrofolate reductase (MTHFR) and induces lower teratogenicity in MTHFR deficiency.
Journal of cellular biochemistry 2008;105(2):467-76.
2008: Leonie G Mikael; Rima Rozen
Homocysteine modulates the effect of simvastatin on expression of ApoA-I and NF-kappaB/iNOS.
Cardiovascular research 2008;80(1):151-8.
2008: Rima Rozen
Interview with Rima Rozen.
Pharmacogenomics 2008;9(9):1187-90.
2008: Basak Celtikci; Daniel Leclerc; Andrea K Lawrance; Liyuan Deng; Hana C Friedman; Natalia I Krupenko; Sergey A Krupenko; Stepan Melnyk; S Jill James; Alan Peterson; Rima Rozen
Altered expression of methylenetetrahydrofolate reductase modifies response to methotrexate in mice.
Pharmacogenetics and genomics 2008;18(7):577-89.
2008: Liyuan Deng; C Lee Elmore; Andrea K Lawrance; Rowena G Matthews; Rima Rozen
Methionine synthase reductase deficiency results in adverse reproductive outcomes and congenital heart defects in mice.
Molecular genetics and metabolism 2008;94(3):336-42.
2008: Deqiang Li; N Karp; Qing Wu; X-L Wang; Stepan Melnyk; S Jill James; Rima Rozen
Mefolinate (5-methyltetrahydrofolate), but not folic acid, decreases mortality in an animal model of severe methylenetetrahydrofolate reductase deficiency.
Journal of inherited metabolic disease 2008;31(3):403-11.
2008: Erin Knock; Liyuan Deng; Qing Wu; Andrea K Lawrance; Xiao-ling Wang; Rima Rozen
Strain differences in mice highlight the role of DNA damage in neoplasia induced by low dietary folate.
The Journal of nutrition 2008;138(4):653-8.
2008: Daniel Leclerc; Rima Rozen
Endoplasmic reticulum stress increases the expression of methylenetetrahydrofolate reductase through the IRE1 transducer.
The Journal of biological chemistry 2008;283(6):3151-60.
2008: Jana Stankova; A K Lawrance; Rima Rozen
Methylenetetrahydrofolate reductase (MTHFR): a novel target for cancer therapy.
Current pharmaceutical design 2008;14(11):1143-50.
2007: Bernd Schwahn; X-L Wang; Leonie G Mikael; Q Wu; J Cohn; H Jiang; K N Maclean; Rima Rozen
Betaine supplementation improves the atherogenic risk factor profile in a transgenic mouse model of hyperhomocysteinemia.
Atherosclerosis 2007;195(2):e100-7.
2007: Andrea K Lawrance; Liyuan Deng; Lawrence C Brody; Richard Finnell; Barry Shane; Rima Rozen
Genetic and nutritional deficiencies in folate metabolism influence tumorigenicity in Apcmin/+ mice.
The Journal of nutritional biochemistry 2007;18(5):305-12.
2006: Erin Knock; Liyuan Deng; Qing Wu; Daniel Leclerc; Xiao-ling Wang; Rima Rozen
Low dietary folate initiates intestinal tumors in mice, with altered expression of G2-M checkpoint regulators polo-like kinase 1 and cell division cycle 25c.
Cancer research 2006;66(21):10349-56.
2006: Deqiang Li; Rima Rozen
Maternal folate deficiency affects proliferation, but not apoptosis, in embryonic mouse heart.
The Journal of nutrition 2006;136(7):1774-8.
2006: Leonie G Mikael; Jacques Genest; Rima Rozen
Elevated homocysteine reduces apolipoprotein A-I expression in hyperhomocysteinemic mice and in males with coronary artery disease.
Circulation research 2006;98(4):564-71.
2006: Deqiang Li; Laura Pickell; Ying Liu; Rima Rozen
Impact of methylenetetrahydrofolate reductase deficiency and low dietary folate on the development of neural tube defects in splotch mice.
Birth defects research. Part A, Clinical and molecular teratology 2006;76(1):55-9.
2005: Laura Pickell; Pamela Tran; Daniel Leclerc; John Hiscott; Rima Rozen
Regulatory studies of murine methylenetetrahydrofolate reductase reveal two major promoters and NF-kappaB sensitivity.
Biochimica et biophysica acta 2005;1731(2):104-14.
2005: Zhoutao Chen; Bernd Schwahn; Qing Wu; Xinying He; Rima Rozen
Postnatal cerebellar defects in mice deficient in methylenetetrahydrofolate reductase.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2005;23(5):465-74.
2005: Deqiang Li; Laura Pickell; Ying Liu; Qing Wu; Jeffrey S Cohn; Rima Rozen
Maternal methylenetetrahydrofolate reductase deficiency and low dietary folate lead to adverse reproductive outcomes and congenital heart defects in mice.
The American journal of clinical nutrition 2005;82(1):188-95.
2005: Chantal F Morel; patrick scott; Ernst Christensen; David S Rosenblatt; Rima Rozen
Prenatal diagnosis for severe methylenetetrahydrofolate reductase deficiency by linkage analysis and enzymatic assay.
Molecular genetics and metabolism 2005;85(2):115-20.
2005: Jitka Stankova; Jijun Shang; Rima Rozen
Antisense inhibition of methylenetetrahydrofolate reductase reduces cancer cell survival in vitro and tumor growth in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(5):2047-52.
2005: Tamara L J Kelly; Oana R Neaga; Bernd Schwahn; Rima Rozen; Jacquetta M Trasler
Infertility in 5,10-methylenetetrahydrofolate reductase (MTHFR)-deficient male mice is partially alleviated by lifetime dietary betaine supplementation.
Biology of reproduction 2005;72(3):667-77.
2005: Marylise Boutros; Caroline Vicanek; Rima Rozen; Paul Goodyer
Transient neonatal cystinuria.
Kidney international 2005;67(2):443-8.
2004: Daniel Leclerc; Liyuan Deng; Jacquetta M Trasler; Rima Rozen
ApcMin/+ mouse model of colon cancer: gene expression profiling in tumors.
Journal of cellular biochemistry 2004;93(6):1242-54.
2004: Bernd Schwahn; Maurice D Laryea; Zhoutao Chen; Stepan Melnyk; Igor P Pogribny; Timothy A Garrow; S Jill James; Rima Rozen
Betaine rescue of an animal model with methylenetetrahydrofolate reductase deficiency.
The Biochemical journal 2004;382(Pt 3):831-40.
2004: Angela M Devlin; Erland Arning; Teodoro Bottiglieri; Frank M Faraci; Rima Rozen; Steven R Lentz
Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice.
Blood 2004;103(7):2624-9.
2003: Daniel Leclerc; Hiba Darwich-Codore; Rima Rozen
Characterization of a pseudogene for murine methylenetetrahydrofolate reductase.
Molecular and cellular biochemistry 2003;252(1-2):391-5.
2003: Isabelle Morin; Angela M Devlin; Daniel Leclerc; Nelly Sabbaghian; Charles H Halsted; Richard Finnell; Rima Rozen
Evaluation of genetic variants in the reduced folate carrier and in glutamate carboxypeptidase II for spina bifida risk.
Molecular genetics and metabolism 2003;79(3):197-200.
2003: Isabelle Morin; Robert Platt; Ilan S Weisberg; Nelly Sabbaghian; Qing Wu; Timothy A Garrow; Rima Rozen
Common variant in betaine-homocysteine methyltransferase (BHMT) and risk for spina bifida.
American journal of medical genetics. Part A 2003;119A(2):172-6.
2003: Victor Cohen; Valerie Panet-Raymond; Nelly Sabbaghian; Isabelle Morin; Gerald Batist; Rima Rozen
Methylenetetrahydrofolate reductase polymorphism in advanced colorectal cancer: a novel genomic predictor of clinical response to fluoropyrimidine-based chemotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(5):1611-5.
2003: Sahar Sibani; Daniel Leclerc; Ilan S Weisberg; Erin O'Ferrall; David Watkins; Carmen Artigas; David S Rosenblatt; Rima Rozen
Characterization of mutations in severe methylenetetrahydrofolate reductase deficiency reveals an FAD-responsive mutation.
Human mutation 2003;21(5):509-20.
2003: Ilan S Weisberg; Eric Park; Karla V Ballman; Peter Berger; Martha Nunn; Daniel S Suh; Andrew P Breksa; Timothy A Garrow; Rima Rozen
Investigations of a common genetic variant in betaine-homocysteine methyltransferase (BHMT) in coronary artery disease.
Atherosclerosis 2003;167(2):205-14.
2003: Bernd Schwahn; Zhoutao Chen; Maurice D Laryea; Udo Wendel; Suzanne Lussier-Cacan; Jacques Genest; Mei-Heng Mar; Steven H Zeisel; Carmen Castro; Timothy A Garrow; Rima Rozen
Homocysteine-betaine interactions in a murine model of 5,10-methylenetetrahydrofolate reductase deficiency.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(3):512-4.
2003: Jacquetta M Trasler; Liyuan Deng; Stepan Melnyk; Igor P Pogribny; Francois Hiou-Tim; Sahar Sibani; Christopher C Oakes; En Li; S Jill James; Rima Rozen
Impact of Dnmt1 deficiency, with and without low folate diets, on tumor numbers and DNA methylation in Min mice.
Carcinogenesis 2003;24(1):39-45.
2002: Laura Arbour; Benedicte Christensen; Treena Delormier; Robert Platt; Brian M Gilfix; Patricia Forbes; Ingrid Kovitch; Joanne Morel; Rima Rozen
Spina bifida, folate metabolism, and dietary folate intake in a Northern Canadian aboriginal population.
International journal of circumpolar health 2002;61(4):341-51.
2002: Daniel Leclerc; Marylise Boutros; Daniel Suh; Qing Wu; Manuel Palacin; James R Ellis; Paul Goodyer; Rima Rozen
SLC7A9 mutations in all three cystinuria subtypes.
Kidney international 2002;62(5):1550-9.
2002: Pamela Tran; Daniel Leclerc; Manuel Chan; Aditya Pai; Francois Hiou-Tim; Qing Wu; Philippe Goyette; Carmen Artigas; Renate Milos; Rima Rozen
Multiple transcription start sites and alternative splicing in the methylenetetrahydrofolate reductase gene result in two enzyme isoforms.
Mammalian genome : official journal of the International Mammalian Genome Society 2002;13(9):483-92.
2002: Pamela Tran; Francois Hiou-Tim; Phyllis Frosst; Suzanne Lussier-Cacan; Pamela Bagley; Jacob Selhub; Teodoro Bottiglieri; Rima Rozen
The curly-tail (ct) mouse, an animal model of neural tube defects, displays altered homocysteine metabolism without folate responsiveness or a defect in Mthfr.
Molecular genetics and metabolism 2002;76(4):297-304.
2002: J Sekhon; P Pereira; Nelly Sabbaghian; A R Schievella; Rima Rozen
Antisense inhibition of methylenetetrahydrofolate reductase reduces survival of methionine-dependent tumour lines.
British journal of cancer 2002;87(2):225-30.
2002: Zhoutao Chen; Bing Ge; Thomas J Hudson; Rima Rozen
Microarray analysis of brain RNA in mice with methylenetetrahydrofolate reductase deficiency and hyperhomocysteinemia.
Brain research. Gene expression patterns 2002;1(2):89-93.
2002: Sahar Sibani; Stepan Melnyk; Igor P Pogribny; Wei Wang; Francois Hiou-Tim; Liyuan Deng; Jacquetta M Trasler; S Jill James; Rima Rozen
Studies of methionine cycle intermediates (SAM, SAH), DNA methylation and the impact of folate deficiency on tumor numbers in Min mice.
Carcinogenesis 2002;23(1):61-5.
2001: Daniel Leclerc; Qing Wu; J R Ellis; Paul Goodyer; Rima Rozen
Is the SLC7A10 gene on chromosome 19 a candidate locus for cystinuria?
Molecular genetics and metabolism 2001;73(4):333-9.
2001: Michael S Kramer; Lise Goulet; J Lydon; Louise Séguin; Helen McNamara; Clément Dassa; Robert W Platt; Moy Fong Chen; H Gauthier; Jacques Genest; S Kahn; Michael D Libman; Rima Rozen; A Masse; L Miner; G Asselin; Alice Benjamin; J Klein; G Koren
Socio-economic disparities in preterm birth: causal pathways and mechanisms.
Paediatric and perinatal epidemiology 2001;15 Suppl 2():104-23.
2001: Ilan S Weisberg; P F Jacques; Jacob Selhub; A G Bostom; Zhoutao Chen; R Curtis Ellison; J H Eckfeldt; Rima Rozen
The 1298A-->C polymorphism in methylenetetrahydrofolate reductase (MTHFR): in vitro expression and association with homocysteine.
Atherosclerosis 2001;156(2):409-15.
2001: R Bissonnette; Eileen P Treacy; Rima Rozen; Betsie Boucher; Jeffrey S Cohn; Jacques Genest
Fenofibrate raises plasma homocysteine levels in the fasted and fed states.
Atherosclerosis 2001;155(2):455-62.
2001: Zhoutao Chen; Andrew C Karaplis; S L Ackerman; Igor P Pogribny; Stepan Melnyk; Suzanne Lussier-Cacan; Moy Fong Chen; Aditya Pai; S W John; R S Smith; Teodoro Bottiglieri; P Bagley; Jacob Selhub; M A Rudnicki; S Jill James; Rima Rozen
Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition.
Human molecular genetics 2001;10(5):433-43.
2001: Bernd Schwahn; Rima Rozen
Polymorphisms in the methylenetetrahydrofolate reductase gene: clinical consequences.
American journal of pharmacogenomics : genomics-related research in drug development and clinical practice 2001;1(3):189-201.
2000: Paul Goodyer; Marylise Boutros; Rima Rozen
The molecular basis of cystinuria: an update.
Experimental nephrology 2000;8(3):123-7.
2000: Rima Rozen
Genetic modulation of homocysteinemia.
Seminars in thrombosis and hemostasis 2000;26(3):255-61.
2000: Philippe Goyette; Rima Rozen
The thermolabile variant 677C-->T can further reduce activity when expressed in cis with severe mutations for human methylenetetrahydrofolate reductase.
Human mutation 2000;16(2):132-8.
2000: Sahar Sibani; Benedicte Christensen; Erin O'Ferrall; I Saadi; Francois Hiou-Tim; David S Rosenblatt; Rima Rozen
Characterization of six novel mutations in the methylenetetrahydrofolate reductase (MTHFR) gene in patients with homocystinuria.
Human mutation 2000;15(3):280-7.
1999: J Ma; Meir J Stampfer; B Christensen; Edward Giovannucci; David J Hunter; Jia Chen; Walter C Willett; J Selhub; Charles H Hennekens; R Gravel; Rima Rozen
A polymorphism of the methionine synthase gene: association with plasma folate, vitamin B12, homocyst(e)ine, and colorectal cancer risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 1999;8(9):825-9.
1999: Aaron Wilson; Robert Platt; Qing Wu; Daniel Leclerc; Benedicte Christensen; H Yang; Roy A Gravel; Rima Rozen
A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida.
Molecular genetics and metabolism 1999;67(4):317-23.
1999: Benedicte Christensen; Laura Arbour; Pamela Tran; Daniel Leclerc; Nelly Sabbaghian; Robert Platt; Brian M Gilfix; David S Rosenblatt; Roy A Gravel; P Forbes; Rima Rozen
Genetic polymorphisms in methylenetetrahydrofolate reductase and methionine synthase, folate levels in red blood cells, and risk of neural tube defects.
American journal of medical genetics 1999;84(2):151-7.
1999: P Pereira; V Stanton; Serge Jothy; I P Tomlinson; W D Foulkes; Rima Rozen
Loss of heterozygosity of methylenetetrahydrofolate reductase in colon carcinomas.
Oncology reports 1999;6(3):597-9.
1998: Philippe Goyette; David S Rosenblatt; Rima Rozen
Homocystinuria (methylenetetrahydrofolate reductase deficiency) and mutation of factor V gene.
Journal of inherited metabolic disease 1998;21(6):690-1.
1998: Philippe Goyette; Aditya Pai; R Milos; Phyllis Frosst; Pamela Tran; Zhoutao Chen; M Chan; Rima Rozen
Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR)
Mammalian genome : official journal of the International Mammalian Genome Society 1998;9(8):652-6.
1998: Ilan S Weisberg; Pamela Tran; Benedicte Christensen; Sahar Sibani; Rima Rozen
A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity.
Molecular genetics and metabolism 1998;64(3):169-72.
1998: Paul Goodyer; I Saadi; P Ong; G Elkas; Rima Rozen
Cystinuria subtype and the risk of nephrolithiasis.
Kidney international 1998;54(1):56-61.
1998: I Saadi; X Z Chen; M Hediger; P Ong; P Pereira; Paul Goodyer; Rima Rozen
Molecular genetics of cystinuria: mutation analysis of SLC3A1 and evidence for another gene in type I (silent) phenotype.
Kidney international 1998;54(1):48-55.
1997: Z X Zhang; Daniel Leclerc; Roy A Gravel; Rima Rozen
The methionine synthase (Mtr) gene maps to proximal mouse chromosome 13.
Mammalian genome : official journal of the International Mammalian Genome Society 1997;8(10):787-8.
1997: Rima Rozen
Genetic predisposition to hyperhomocysteinemia: deficiency of methylenetetrahydrofolate reductase (MTHFR).
Thrombosis and haemostasis 1997;78(1):523-6.
1997: J Ma; Meir J Stampfer; Edward Giovannucci; Carmen Artigas; David J Hunter; C Fuchs; Walter C Willett; J Selhub; Charles H Hennekens; Rima Rozen
Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer.
Cancer research 1997;57(6):1098-102.
1997: Benedicte Christensen; Phyllis Frosst; Suzanne Lussier-Cacan; Jacob Selhub; Philippe Goyette; David S Rosenblatt; Jacques Genest; Rima Rozen
Correlation of a common mutation in the methylenetetrahydrofolate reductase gene with plasma homocysteine in patients with premature coronary artery disease.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(3):569-73.
1996: Daniel Leclerc; E Campeau; Philippe Goyette; C E Adjalla; Benedicte Christensen; M Ross; P Eydoux; David S Rosenblatt; Rima Rozen; Roy A Gravel
Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders.
Human molecular genetics 1996;5(12):1867-74.
1996: Philippe Goyette; Benedicte Christensen; David S Rosenblatt; Rima Rozen
Severe and mild mutations in cis for the methylenetetrahydrofolate reductase (MTHFR) gene, and description of five novel mutations in MTHFR.
American journal of human genetics 1996;59(6):1268-75.
1996: J Ma; Meir J Stampfer; Charles H Hennekens; Phyllis Frosst; Jacob Selhub; J Horsford; M Rene Malinow; Walter C Willett; Rima Rozen
Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians.
Circulation 1996;94(10):2410-6.
1996: Phyllis Frosst; Z Zhang; A Pai; Rima Rozen
The methylenetetrahydrofolate reductase (Mthfr) gene maps to distal mouse chromosome 4.
Mammalian genome : official journal of the International Mammalian Genome Society 1996;7(11):864-5.
1996: J Willard; C Vicanek; Kevin P Battaile; P P Van Veldhoven; Abdul Fauq; Rima Rozen; Jerry Vockley
Cloning of a cDNA for short/branched chain acyl-Coenzyme A dehydrogenase from rat and characterization of its tissue expression and substrate specificity.
Archives of biochemistry and biophysics 1996;331(1):127-33.
1996: Rima Rozen
Molecular genetic aspects of hyperhomocysteinemia and its relation to folic acid.
Clinical and investigative medicine. Médecine clinique et experimentale 1996;19(3):171-8.
1996: J Horsford; I Saadi; J Raelson; Paul Goodyer; Rima Rozen
Molecular genetics of cystinuria in French Canadians: identification of four novel mutations in type I patients.
Kidney international 1996;49(5):1401-6.
1996: Rima Rozen
Molecular genetics of methylenetetrahydrofolate reductase deficiency.
Journal of inherited metabolic disease 1996;19(5):589-94.
1996: Leo A J Kluijtmans; L P van den Heuvel; Godfried H J Boers; Phyllis Frosst; E M Stevens; BA van Oost; Martin den Heijer; Frans J M Trijbels; Rima Rozen; Henk J Blom
Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease.
American journal of human genetics 1996;58(1):35-41.
1995: N M J van der Put; Régine P M Steegers-Theunissen; Phyllis Frosst; Frans J M Trijbels; Tom K A B Eskes; L P van den Heuvel; Edwin C M Mariman; M den Heyer; Rima Rozen; Henk J Blom
Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida.
Lancet 1995;346(8982):1070-1.
1995: Rima Rozen; L Ferreira-Rajabi; L Robb; N Colman
L206W mutation of the cystic fibrosis gene, relatively frequent in French Canadians, is associated with atypical presentations of cystic fibrosis.
American journal of medical genetics 1995;57(3):437-9.
1995: Philippe Goyette; Phyllis Frosst; David S Rosenblatt; Rima Rozen
Seven novel mutations in the methylenetetrahydrofolate reductase gene and genotype/phenotype correlations in severe methylenetetrahydrofolate reductase deficiency.
American journal of human genetics 1995;56(5):1052-9.
1994: X X Zhang; Rima Rozen; M A Hediger; Paul Goodyer; P Eydoux
Assignment of the gene for cystinuria (SLC3A1) to human chromosome 2p21 by fluorescence in situ hybridization.
Genomics 1994;24(2):413-4.
1994: Rima Rozen; Jerry Vockley; L Zhou; R Milos; J Willard; K Fu; C Vicanek; L Low-Nang; Elena Torban; B Fournier
Isolation and expression of a cDNA encoding the precursor for a novel member (ACADSB) of the acyl-CoA dehydrogenase gene family.
Genomics 1994;24(2):280-7.
1994: Philippe Goyette; J S Sumner; R Milos; A M Duncan; David S Rosenblatt; Rowena G Matthews; Rima Rozen
Human methylenetetrahydrofolate reductase: isolation of cDNA mapping and mutation identification.
Nature genetics 1994;7(4):551.
1994: Rima Rozen; A Mascisch; Marie Lambert; R Laframboise; Charles R Scriver
Mutation profiles of phenylketonuria in Quebec populations: evidence of stratification and novel mutations.
American journal of human genetics 1994;55(2):321-6.
1994: Philippe Goyette; J S Sumner; R Milos; A M Duncan; David S Rosenblatt; Rowena G Matthews; Rima Rozen
Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification.
Nature genetics 1994;7(2):195-200.
1993: R J Fagan; Rima Rozen
Translational control of ornithine-delta-aminotransferase (OAT) by estrogen.
Molecular and cellular endocrinology 1993;90(2):171-7.
1992: Rima Rozen; Marc de Braekeleer; J Daigneault; L Ferreira-Rajabi; M Gerdes; L Lamoureux; G Aubin; F Simard; T M Fujiwara; Kenneth Morgan
Cystic fibrosis mutations in French Canadians: three CFTR mutations are relatively frequent in a Quebec population with an elevated incidence of cystic fibrosis.
American journal of medical genetics 1992;42(3):360-4.
1992: S W John; Charles R Scriver; R Laframboise; Rima Rozen
In vitro and in vivo correlations for I65T and M1V mutations at the phenylalanine hydroxylase locus.
Human mutation 1992;1(2):147-53.
1992: S W John; Rima Rozen; R Laframboise; C Laberge; Charles R Scriver
Five mutations at the PAH locus account for almost 90% of PKU mutations in French-Canadians from eastern Quebec.
Human mutation 1992;1(1):72-4.
1991: R J Fagan; A Lazaris-Karatzas; Nahum Sonenberg; Rima Rozen
Translational control of ornithine aminotransferase. Modulation by initiation factor eIF-4E.
The Journal of biological chemistry 1991;266(25):16518-23.
1991: C Italiano; S W John; D W Hum; Robert E MacKenzie; Rima Rozen
A pseudogene on the X chromosome for the human trifunctional enzyme MTHFD (methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase).
Genomics 1991;10(4):1073-4.
1991: A Mascisch; Rima Rozen
Deficient synthesis of MTHFD, a trifunctional folate-dependent enzyme, in the CHO Ade E mutant.
Somatic cell and molecular genetics 1991;17(4):391-8.
1991: D M Slipetz; P R Goodyer; Rima Rozen
Congenital deficiency of a 20-kDa subunit of mitochondrial complex I in fibroblasts.
American journal of human genetics 1991;48(6):1121-6.
1991: D M Slipetz; June Aprille; P R Goodyer; Rima Rozen
Deficiency of complex III of the mitochondrial respiratory chain in a patient with facioscapulohumeral disease.
American journal of human genetics 1991;48(3):502-10.
1991: S W John; G Weitzner; Rima Rozen; Charles R Scriver
A rapid procedure for extracting genomic DNA from leukocytes.
Nucleic acids research 1991;19(2):408.
1990: Rima Rozen; R H Schwartz; B C Hilman; P Stanislovitis; Glenn T Horn; Katherine W Klinger; J Daigneault; Marc de Braekeleer; B Kerem; Lap-Chee Tsui
Cystic fibrosis mutations in North American populations of French ancestry: analysis of Quebec French-Canadian and Louisiana Acadian families.
American journal of human genetics 1990;47(4):606-10.
1990: S W John; Rima Rozen; Charles R Scriver; R Laframboise; C Laberge
Recurrent mutation, gene conversion, or recombination at the human phenylalanine hydroxylase locus: evidence in French-Canadians and a catalog of mutations.
American journal of human genetics 1990;46(5):970-4.
1989: R J Fagan; W P Sheffield; Rima Rozen
Regulation of ornithine aminotransferase in retinoblastomas.
The Journal of biological chemistry 1989;264(34):20513-7.
1989: S W John; Rima Rozen; R Laframboise; C Laberge; Charles R Scriver
Novel PKU mutation on haplotype 2 in French-Canadians.
American journal of human genetics 1989;45(6):905-9.
1989: Rima Rozen; David Barton; J Du; D W Hum; Robert E MacKenzie; U Francke
Chromosomal localization of the gene for the human trifunctional enzyme, methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase.
American journal of human genetics 1989;44(6):781-6.
1988: D W Hum; Alexander (Alex) Bell; Rima Rozen; Robert E MacKenzie
Primary structure of a human trifunctional enzyme. Isolation of a cDNA encoding methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase.
The Journal of biological chemistry 1988;263(31):15946-50.
1985: Rima Rozen; D W Hum; Robert E MacKenzie
In vitro synthesis of the trifunctional protein, methylenetetrahydrofolate dehydrogenase--methenyltetrahydrofolate cyclohydrolase--formyltetrahydrofolate synthetase, in normal and transformed cells.
Canadian journal of biochemistry and cell biology = Revue canadienne de biochimie et biologie cellulaire 1985;63(11):1189-93.