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Richard Rozmahel

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Zareen Amtul; Richard Rozmahel; Markus Uhrig; Lin Wang; Konrad Beyreuther
Detrimental effects of arachidonic acid and its metabolites in cellular and mouse models of Alzheimer's disease: structural insight.
Zareen Amtul; Mary Keet; Peter Merrifield; Lin Wang; David Westaway; Richard Rozmahel
DHA supplemented in peptamen diet offers no advantage in pathways to amyloidosis: is it time to evaluate composite lipid diet?
Zareen Amtul; L Wang; D Westaway; Richard Rozmahel
Neuroprotective mechanism conferred by 17beta-estradiol on the biochemical basis of Alzheimer's disease.

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All Publications

2012: Zareen Amtul; Richard Rozmahel; Markus Uhrig; Lin Wang; Konrad Beyreuther
Detrimental effects of arachidonic acid and its metabolites in cellular and mouse models of Alzheimer's disease: structural insight.
Neurobiology of aging 2012;33(4):831.e21-31.
2011: Zareen Amtul; Mary Keet; Peter Merrifield; Lin Wang; David Westaway; Richard Rozmahel
DHA supplemented in peptamen diet offers no advantage in pathways to amyloidosis: is it time to evaluate composite lipid diet?
PloS one 2011;6(9):e24094.
2010: Zareen Amtul; L Wang; D Westaway; Richard Rozmahel
Neuroprotective mechanism conferred by 17beta-estradiol on the biochemical basis of Alzheimer's disease.
Neuroscience 2010;169(2):781-6.
2007: Fiona D Young; Susan Newbigging; Caroline Choi; Mary Keet; Geraldine Kent; Richard Rozmahel
Amelioration of cystic fibrosis intestinal mucous disease in mice by restoration of mCLCA3.
Gastroenterology 2007;133(6):1928-37.
2007: Kim S Sugamori; D Brenneman; S Wong; Andrea Gaedigk; V Yu; Hanan Abramovici; Richard Rozmahel; Denis M Grant
Effect of arylamine acetyltransferase Nat3 gene knockout on N-acetylation in the mouse.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(7):1064-70.
2007: Sonya Brijbassi; Zareen Amtul; Susan Newbigging; David Westaway; Peter St George-Hyslop; Richard Rozmahel
Excess of nicastrin in brain results in heterozygosity having no effect on endogenous APP processing and amyloid peptide levels in vivo.
Neurobiology of disease 2007;25(2):291-6.
2006: Zareen Amtul; Naheed Kausar; Cristian Follmer; Richard Rozmahel; Syed Arif Kazmi; Mohammed Saleh Shekhani; Jason Eriksen; Khalid M Khan; M Iqbal Choudhary
Cysteine based novel noncompetitive inhibitors of urease(s)--distinctive inhibition susceptibility of microbial and plant ureases.
Bioorganic & medicinal chemistry 2006;14(19):6737-44.
2006: Van Nguyen; Cynthia Hawkins; Catherine Bergeron; Agnes Supala; Jean Huang; David Westaway; Peter St George-Hyslop; Richard Rozmahel
Loss of nicastrin elicits an apoptotic phenotype in mouse embryos.
Brain research 2006;1086(1):76-84.
2006: Sam Tirkos; Susan Newbigging; Van Nguyen; Mary Keet; Cameron Ackerley; Geraldine Kent; Richard Rozmahel
Expression of S100A8 correlates with inflammatory lung disease in congenic mice deficient of the cystic fibrosis transmembrane conductance regulator.
Respiratory research 2006;7():51.
2005: Peter Mastrangelo; Paul Mathews; M Azhar Chishti; Stephen D Schmidt; Yongjun Gu; Jing Yang; Matthew J Mazzella; Janaky Coomaraswamy; Patrick Horne; Bob Strome; Heather Pelly; Georges Levesque; Christine Ebeling; Ying Jiang; Ralph A. Nixon; Richard Rozmahel; Paul E Fraser; Peter St George-Hyslop; George A Carlson; David Westaway
Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(25):8972-7.
2003: Kim S Sugamori; Sharon Wong; Andrea Gaedigk; Violeta Yu; Hanan Abramovici; Richard Rozmahel; Denis M Grant
Generation and functional characterization of arylamine N-acetyltransferase Nat1/Nat2 double-knockout mice.
Molecular pharmacology 2003;64(1):170-9.
2003: Richard Rozmahel
Mouse genome modification.
Methods in molecular medicine 2003;89():529-44.
2002: Jennifer Liauw; Van Nguyen; Jean Huang; Peter St George-Hyslop; Richard Rozmahel
Differential display analysis of presenilin 1-deficient mouse brains.
Brain research. Molecular brain research 2002;109(1-2):56-62.
2002: Christina K Haston; Colin McKerlie; Susan Newbigging; Mary Corey; Richard Rozmahel; Lap-Chee Tsui
Detection of modifier loci influencing the lung phenotype of cystic fibrosis knockout mice.
Mammalian genome : official journal of the International Mammalian Genome Society 2002;13(11):605-13.
2002: Richard Rozmahel; Howard T J Mount; Fusheng Chen; Van Nguyen; Jean Huang; Serap Erdebil; Jennifer Liauw; Gang G. Yu; Hiroshe Hasegawa; YongJun Gu; You-Qiang Song; Stephen D Schmidt; Ralph A. Nixon; Paul Mathews; Catherine Bergeron; Paul E Fraser; David Westaway; Peter St George-Hyslop
Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14452-7.
2002: Richard Rozmahel; Jean Huang; Fusheng Chen; Yan Liang; Van Nguyen; Masaki Ikeda; Georges Levesque; Gang G. Yu; M Nishimura; Paul Mathews; Stephen D Schmidt; Marc Mercken; Catherine Bergeron; David Westaway; Peter St George-Hyslop
Normal brain development in PS1 hypomorphic mice with markedly reduced gamma-secretase cleavage of betaAPP.
Neurobiology of aging 2002;23(2):187-94.
2001: Taiichi Katayama; Kazunori Imaizumi; A Honda; Toshiyuki Yoneda; Takashi Kudo; Masatoshi Takeda; K Mori; Richard Rozmahel; Paul E Fraser; Peter St George-Hyslop; Masaya Tohyama
Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer's disease-linked presenilin-1 mutations.
The Journal of biological chemistry 2001;276(46):43446-54.
2000: K Gyömörey; Richard Rozmahel; Christine E Bear
Amelioration of intestinal disease severity in cystic fibrosis mice is associated with improved chloride secretory capacity.
Pediatric research 2000;48(6):731-4.
2000: Fusheng Chen; Dun-Sheng Yang; Suzana Petanceska; Austin Yang; Anurag Tandon; Gang G. Yu; Richard Rozmahel; Jorge Ghiso; M Nishimura; DM Zhang; Toshitaka Kawarai; Georges Levesque; J Mills; L Levesque; You-Qiang Song; Ekaterina Rogaeva; David Westaway; Howard T J Mount; Sam Gandy; Peter St George-Hyslop; Paul E Fraser
Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.
The Journal of biological chemistry 2000;275(47):36794-802.
2000: mariagrazia grilli; E Diodato; Gianluca Lozza; Rossella Brusa; M Casarini; Daniela Uberti; Richard Rozmahel; David Westaway; Peter St George-Hyslop; Maurizio Memo; Ennio Ongini
Presenilin-1 regulates the neuronal threshold to excitotoxicity both physiologically and pathologically.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(23):12822-7.
1999: Julian Zielenski; Mary Corey; Richard Rozmahel; Danuta Markiewicz; Isabel Aznarez; Teresa Casals; Sara Larriba; B Mercier; Garry R Cutting; Alice Krebsova; Milan Macek Jr.; E Langfelder-Schwind; B C Marshall; Joan Decelie-Germana; M Claustres; AM Palacio; Jerzy Bal; A Nowakowska; C Ferec; Xavier Estivill; Peter Roy Durie; Lap-Chee Tsui
Detection of a cystic fibrosis modifier locus for meconium ileus on human chromosome 19q13.
Nature genetics 1999;22(2):128-9.
1999: M Nishimura; Gang G. Yu; Georges Levesque; DM Zhang; L Ruel; Fusheng Chen; P Milman; E Holmes; Yan Liang; Toshitaka Kawarai; E Jo; Agnes Supala; Ekaterina Rogaeva; D M Xu; Christopher Janus; L Levesque; Q Bi; Monika Duthie; Richard Rozmahel; K Mattila; Lars Lannfelt; David Westaway; Howard T J Mount; James R Woodgett; Peter St George-Hyslop
Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex.
Nature medicine 1999;5(2):164-9.
1997: Richard Rozmahel; Hong-Qiang Heng; AM Duncan; XM Shi; Johanna M Rommens; Lap-Chee Tsui
Amplification of CFTR exon 9 sequences to multiple locations in the human genome.
Genomics 1997;45(3):554-61.
1997: Richard Rozmahel; K Gyömörey; S Plyte; Van Nguyen; Michael Wilschanski; Peter Roy Durie; Christine E Bear; Lap-Chee Tsui
Incomplete rescue of cystic fibrosis transmembrane conductance regulator deficient mice by the human CFTR cDNA.
Human molecular genetics 1997;6(7):1153-62.
1996: Richard Rozmahel; Michael Wilschanski; A Matin; S Plyte; M Oliver; Wojtek Auerbach; A Moore; J Forstner; Peter Roy Durie; J Nadeau; Christine E Bear; Lap-Chee Tsui
Modulation of disease severity in cystic fibrosis transmembrane conductance regulator deficient mice by a secondary genetic factor.
Nature genetics 1996;12(3):280-7.
1996: Michael Wilschanski; Richard Rozmahel; Satti Beharry; Geraldine Kent; Canhui Li; Lap-Chee Tsui; Peter Roy Durie; Christine E Bear
In vivo measurements of ion transport in long-living CF mice.
Biochemical and biophysical research communications 1996;219(3):753-9.
1992: H Jin; D Oksenberg; Avi Ashkenazi; S J Peroutka; AM Duncan; Richard Rozmahel; Y Yang; G Mengod; J M Palacios; Brian F O'Dowd
Characterization of the human 5-hydroxytryptamine1B receptor.
The Journal of biological chemistry 1992;267(9):5735-8.
1991: J L Chou; Richard Rozmahel; Lap-Chee Tsui
Characterization of the promoter region of the cystic fibrosis transmembrane conductance regulator gene.
The Journal of biological chemistry 1991;266(36):24471-6.
1991: T Yorifuji; W K Lemna; C F Ballard; C L Rosenbloom; Richard Rozmahel; N Plavsic; Lap-Chee Tsui; Arthur L Beaudet
Molecular cloning and sequence analysis of the murine cDNA for the cystic fibrosis transmembrane conductance regulator.
Genomics 1991;10(3):547-50.
1991: Julian Zielenski; Richard Rozmahel; Dominique Bozon; Batsheva Kerem; Z Grzelczak; John R Riordan; Johanna M Rommens; Lap-Chee Tsui
Genomic DNA sequence of the cystic fibrosis transmembrane conductance regulator (CFTR) gene.
Genomics 1991;10(1):214-28.
1991: Lap-Chee Tsui; Johanna M Rommens; Batsheva Kerem; Richard Rozmahel; Julian Zielenski; D Kennedy; Danuta Markiewicz; N Plavsic; J L Chou; Dominique Bozon
Molecular genetics of cystic fibrosis.
Advances in experimental medicine and biology 1991;290():9-17; discussion 17-8.
1990: Roger K Sunahara; Hyman B Niznik; D M Weiner; T M Stormann; Mark R Brann; James L Kennedy; Joel Gelernter; Richard Rozmahel; Y L Yang; Y Israel
Human dopamine D1 receptor encoded by an intronless gene on chromosome 5.
Nature 1990;347(6288):80-3.
1989: Johanna M Rommens; Michael C Iannuzzi; Batsheva Kerem; Mitchell L Drumm; G Melmer; M Dean; Richard Rozmahel; J L Cole; D Kennedy; N Hidaka
Identification of the cystic fibrosis gene: chromosome walking and jumping.
Science (New York, N.Y.) 1989;245(4922):1059-65.
1989: John R Riordan; Johanna M Rommens; Batsheva Kerem; Noa Alon; Richard Rozmahel; Z Grzelczak; Julian Zielenski; S Lok; N Plavsic; J L Chou
Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA.
Science (New York, N.Y.) 1989;245(4922):1066-73.
1988: Johanna M Rommens; S Zengerling; J Burns; G Melmer; Batsheva Kerem; N Plavsic; M Zsiga; D Kennedy; Danuta Markiewicz; Richard Rozmahel
Identification and regional localization of DNA markers on chromosome 7 for the cloning of the cystic fibrosis gene.
American journal of human genetics 1988;43(5):645-63.