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Ke-He Ruan

Research Profile

Chemicals & Drugs

Genes & Molecular Sequences

Amino Acid Sequences

Concepts & Ideas

Anatomy

Phenomena

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Nuclear Magnetic Resonance, Biomolecular

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Publications

TOP 3
Ke-He Ruan; Shui-Ping So; Anita Mohite; Cheng-Huai Ruan
Establishing novel prostacyclin-synthesizing cells with therapeutic potential against heart diseases.
Qi Liu; Xiaobing Liu; Anita Mohite; Ke-He Ruan; Shui-Ping So; Toya Terry; James T Willerson; Geru Wu; Yutao Xi; Jia Zhang; Jie Cheng; Richard A F Dixon
Engineered endothelial progenitor cells that overexpress prostacyclin protect vascular cells.
Yanjie Chen; Andrew Chiu; Hung Doan; Jui-Yoa Chang; Takayuki Fujita; Yuichi Koide; Curtis Chen-Jen Lin; Zhihe Liu; DECHA PINKAEW; Ke-He Ruan; Jiaxin Wu; Di Zhang; Ken Fujise
Physical and functional antagonism between tumor suppressor protein p53 and fortilin, an anti-apoptotic protein.

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All Publications

2013: Ke-He Ruan; Shui-Ping So; Anita Mohite; Cheng-Huai Ruan
Establishing novel prostacyclin-synthesizing cells with therapeutic potential against heart diseases.
International journal of cardiology 2013;163(2):163-9.
2012: Qi Liu; Xiaobing Liu; Anita Mohite; Ke-He Ruan; Shui-Ping So; Toya Terry; James T Willerson; Geru Wu; Yutao Xi; Jia Zhang; Jie Cheng; Richard A F Dixon
Engineered endothelial progenitor cells that overexpress prostacyclin protect vascular cells.
Journal of cellular physiology 2012;227(7):2907-16.
2011: Yanjie Chen; Andrew Chiu; Hung Doan; Jui-Yoa Chang; Takayuki Fujita; Yuichi Koide; Curtis Chen-Jen Lin; Zhihe Liu; DECHA PINKAEW; Ke-He Ruan; Jiaxin Wu; Di Zhang; Ken Fujise
Physical and functional antagonism between tumor suppressor protein p53 and fortilin, an anti-apoptotic protein.
The Journal of biological chemistry 2011;286(37):32575-85.
2011: Annirudha Chillar; Yong-Jian Geng; Cheng-Huai Ruan; Harnath Shelat; Shui-Ping So; Ke-He Ruan
A profile of NSAID-targeted arachidonic acid metabolisms in human embryonic stem cells (hESCs): implication of the negative effects of NSAIDs on heart tissue regeneration.
International journal of cardiology 2011;150(3):253-9.
2011: Anita Mohite; Annirudha Chillar; Shui-Ping So; Vanessa Cervantes; Ke-He Ruan
Novel mechanism of the vascular protector prostacyclin: regulating microRNA expression.
Biochemistry 2011;50(10):1691-9.
2011: Cheng-Huai Ruan; Shui-Ping So; Ke-He Ruan
Inducible COX-2 dominates over COX-1 in prostacyclin biosynthesis: mechanisms of COX-2 inhibitor risk to heart disease.
Life sciences 2011;88(1-2):24-30.
2011: Annirudha J Chillar; Parastoo Karimi; Kathy Tang; Ke-He Ruan
An agonist sensitive, quick and simple cell-based signaling assay for determination of ligands mimicking prostaglandin E2 or E1 activity through subtype EP1 receptor: Suitable for high throughput screening.
BMC complementary and alternative medicine 2011;11():11.
2010: Annirudha Chillar; Jiaxin Wu; Vanessa Cervantes; Ke-He Ruan
Structural and functional analysis of the C-terminus of Galphaq in complex with the human thromboxane A2 receptor provides evidence of constitutive activity.
Biochemistry 2010;49(30):6365-74.
2010: Cheng-Huai Ruan; Richard A F Dixon; James T Willerson; Ke-He Ruan
Prostacyclin therapy for pulmonary arterial hypertension.
Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital 2010;37(4):391-9.
2009: Ke-He Ruan; Vanessa Cervantes; Shui-Ping So
Engineering of a novel hybrid enzyme: an anti-inflammatory drug target with triple catalytic activities directly converting arachidonic acid into the inflammatory prostaglandin E2.
Protein engineering, design & selection : PEDS 2009;22(12):733-40.
2009: Ke-He Ruan; Vanessa Cervantes; Jiaxin Wu
Ligand-specific conformation determines agonist activation and antagonist blockade in purified human thromboxane A2 receptor.
Biochemistry 2009;48(14):3157-65.
2009: Jiuhong Yuan; O Lenaine Westney; Ke-He Ruan; Run Wang
A new strategy, SuperEnzyme gene therapy in penile rehabilitation.
The journal of sexual medicine 2009;6 Suppl 3():328-33.
2008: Ke-He Ruan; Shui-Ping So; Vanessa Cervantes; Hanjing Wu; Cori Wijaya; Rebecca R Jentzen
An active triple-catalytic hybrid enzyme engineered by linking cyclo-oxygenase isoform-1 to prostacyclin synthase that can constantly biosynthesize prostacyclin, the vascular protector.
The FEBS journal 2008;275(23):5820-9.
2008: Ke-He Ruan; Shui-Ping So; Hanjing Wu; Vanessa Cervantes
Large-scale expression, purification, and characterization of an engineered prostacyclin-synthesizing enzyme with therapeutic potential.
Archives of biochemistry and biophysics 2008;480(1):41-50.
2008: Ke-He Ruan; Cori Wijaya; Vanessa Cervantes; Jiaxin Wu
Characterization of the prostaglandin H2 mimic: binding to the purified human thromboxane A2 receptor in solution.
Archives of biochemistry and biophysics 2008;477(2):396-403.
2008: Annirudha Chillar; Jiaxin Wu; Shui-Ping So; Ke-He Ruan
Involvement of non-conserved residues important for PGE2 binding to the constrained EP3 eLP2 using NMR and site-directed mutagenesis.
FEBS letters 2008;582(19):2863-8.
2008: Ke-He Ruan; Vanessa Cervantes; Jiaxin Wu
A simple, quick, and high-yield preparation of the human thromboxane A2 receptor in full size for structural studies.
Biochemistry 2008;47(26):6819-26.
2008: Jiaxin Wu; Mary Feng; Ke-He Ruan
Assembling NMR structures for the intracellular loops of the human thromboxane A2 receptor: implication of the G protein-coupling pocket.
Archives of biochemistry and biophysics 2008;470(1):73-82.
2008: Ke-He Ruan; Jiaxin Wu; Vanessa Cervantes
Characterization of the substrate mimic bound to engineered prostacyclin synthase in solution using high-resolution NMR spectroscopy and mutagenesis: implication of the molecular mechanism in biosynthesis of prostacyclin.
Biochemistry 2008;47(2):680-8.
2008: Feng Ni; Shui-Ping So; Vanessa Cervantes; Ke-He Ruan
A profile of the residues in the second extracellular loop that are critical for ligand recognition of human prostacyclin receptor.
The FEBS journal 2008;275(1):128-37.
2006: Ke-He Ruan; Hui Deng; Shui-Ping So
Engineering of a protein with cyclooxygenase and prostacyclin synthase activities that converts arachidonic acid to prostacyclin.
Biochemistry 2006;45(47):14003-11.
2006: Lihai Zhang; Murat Bastepe; Harald Jüppner; Ke-He Ruan
Characterization of the molecular mechanisms of the coupling between intracellular loops of prostacyclin receptor with the C-terminal domain of the Galphas protein in human coronary artery smooth muscle cells.
Archives of biochemistry and biophysics 2006;454(1):80-8.
2006: Jaou-Chen Huang; Cheng-Huai Ruan; Kathy Tang; Ke-He Ruan
Prunella stica inhibits the proliferation but not the prostaglandin production of Ishikawa cells.
Life sciences 2006;79(5):436-41.
2006: Lihai Zhang; Jiaxin Wu; Ke-He Ruan
Solution structure of the first intracellular loop of prostacyclin receptor and implication of its interaction with the C-terminal segment of G alpha s protein.
Biochemistry 2006;45(6):1734-44.
2006: Ke-He Ruan; Jean-Michel Dogné
Implications of the molecular basis of prostacyclin biosynthesis and signaling in pharmaceutical designs.
Current pharmaceutical design 2006;12(8):925-41.
2006: Jean-Michel Dogné; Julien Hanson; Xavier de Leval; Domenico Pratico'; Cecil R Pace-Asciak; Pierre Drion; Bernard Pirotte; Ke-He Ruan
From the design to the clinical application of thromboxane modulators.
Current pharmaceutical design 2006;12(8):903-23.
2005: Ke-He Ruan; Jiaxin Wu; Lee-Ho Wang
Solution structure of a common substrate mimetic of cyclooxygenase-downstream synthases bound to an engineered thromboxane A2 synthase using a high-resolution NMR technique.
Archives of biochemistry and biophysics 2005;444(2):165-73.
2005: Lihai Zhang; Gangxiong Huang; Jiaxin Wu; Ke-He Ruan
A profile of the residues in the first intracellular loop critical for Gs-mediated signaling of human prostacyclin receptor characterized by an integrative approach of NMR-experiment and mutagenesis.
Biochemistry 2005;44(34):11389-401.
2005: Ke-He Ruan; Hui Deng; Jiaxin Wu; Shui-Ping So
The N-terminal membrane anchor domain of the membrane-bound prostacyclin synthase involved in the substrate presentation of the coupling reaction with cyclooxygenase.
Archives of biochemistry and biophysics 2005;435(2):372-81.
2005: Cheng-Huai Ruan; Jaixin Wu; Ke-He Ruan
A strategy using NMR peptide structures of thromboxane A2 receptor as templates to construct ligand-recognition pocket of prostacyclin receptor.
BMC biochemistry 2005;6():23.
2004: Ke-He Ruan
Advance in understanding the biosynthesis of prostacyclin and thromboxane A2 in the endoplasmic reticulum membrane via the cyclooxygenase pathway.
Mini reviews in medicinal chemistry 2004;4(6):639-47.
2004: Ke-He Ruan; Jiaxin Wu; Shui-Ping So; Lori A Jenkins; Cheng-Huai Ruan
NMR structure of the thromboxane A2 receptor ligand recognition pocket.
European journal of biochemistry / FEBS 2004;271(14):3006-16.
2004: Jean-Michel Dogné; Xavier de Leval; Julien Hanson; Michel Frederich; Bernard Lambermont; Alexandre Ghuysen; Angela Casini; Bernard Masereel; Ke-He Ruan; Bernard Pirotte; Philippe Kolh
New developments on thromboxane and prostacyclin modulators part I: thromboxane modulators.
Current medicinal chemistry 2004;11(10):1223-41.
2004: Linda Geng; Jiaxin Wu; Shui-Ping So; Gangxiong Huang; Ke-He Ruan
Structural and functional characterization of the first intracellular loop of human thromboxane A2 receptor.
Archives of biochemistry and biophysics 2004;423(2):253-65.
2003: Ke-He Ruan; Jiaxin Wu; Shui-Ping So; Lori A Jenkins
Evidence of the residues involved in ligand recognition in the second extracellular loop of the prostacyclin receptor characterized by high resolution 2D NMR techniques.
Archives of biochemistry and biophysics 2003;418(1):25-33.
2003: Jiaxin Wu; Shui-Ping So; Ke-He Ruan
Solution structure of the third extracellular loop of human thromboxane A2 receptor.
Archives of biochemistry and biophysics 2003;414(2):287-93.
2003: Hui Deng; Jiaxin Wu; Shui-Ping So; Ke-He Ruan
Identification of the residues in the helix F/G loop important to catalytic function of membrane-bound prostacyclin synthase.
Biochemistry 2003;42(19):5609-17.
2003: Shui-Ping So; Jiaxin Wu; Gangxiong Huang; Aimin Huang; Dawei Li; Ke-He Ruan
Identification of residues important for ligand binding of thromboxane A2 receptor in the second extracellular loop using the NMR experiment-guided mutagenesis approach.
The Journal of biological chemistry 2003;278(13):10922-7.
2003: Jiaxin Wu; Shui-Ping So; Ke-He Ruan
Determination of the membrane contact residues and solution structure of the helix F/G loop of prostaglandin I2 synthase.
Archives of biochemistry and biophysics 2003;411(1):27-35.
2002: Ke-He Ruan; Shui-Ping So; Weida Zheng; Jiaxin Wu; Dawei Li; Jennifer Kung
Solution structure and topology of the N-terminal membrane anchor domain of a microsomal cytochrome P450: prostaglandin I2 synthase.
The Biochemical journal 2002;368(Pt 3):721-8.
2002: Farinaz Arbab; Jennifer S Goldsby; Nena Matijevic-Aleksic; Gangxiong Huang; Ke-He Ruan; Jaou-Chen Huang
Prostacyclin is an autocrine regulator in the contraction of oviductal smooth muscle.
Human reproduction (Oxford, England) 2002;17(12):3053-9.
2002: Wu-Guo Deng; Michael A Saunders; Derek W Gilroy; Xue-Zhong He; Howard Yeh; Ying Zhu; Mikhail I Shtivelband; Ke-He Ruan; Kenneth K Wu
Purification and characterization of a cyclooxygenase-2 and angiogenesis suppressing factor produced by human fibroblasts.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(10):1286-8.
2002: Hui Deng; Aimin Huang; Shui-Ping So; Yue-Zhen Lin; Ke-He Ruan
Substrate access channel topology in membrane-bound prostacyclin synthase.
The Biochemical journal 2002;362(Pt 3):545-51.
2001: Wu-Guo Deng; Ke-He Ruan; M Du; Michael A Saunders; Kenneth K Wu
Aspirin and salicylate bind to immunoglobulin heavy chain binding protein (BiP) and inhibit its ATPase activity in human fibroblasts.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(13):2463-70.
2001: Ke-He Ruan; Shui-Ping So; Jiaxin Wu; Dawei Li; Aimin Huang; J Kung
Solution structure of the second extracellular loop of human thromboxane A2 receptor.
Biochemistry 2001;40(1):275-80.
2000: Shui-Ping So; Dawei Li; Ke-He Ruan
Identification of the substrate interaction site in the N-terminal membrane anchor segment of thromboxane A2 synthase by determination of its substrate analog conformational changes using high resolution NMR technique.
The Journal of biological chemistry 2000;275(52):40679-85.
2000: Yue-Zhen Lin; Hui Deng; Ke-He Ruan
Topology of catalytic portion of prostaglandin I(2) synthase: identification by molecular modeling-guided site-specific antibodies.
Archives of biochemistry and biophysics 2000;379(2):188-97.
1998: Y Lin; K K Wu; Ke-He Ruan
Characterization of the secondary structure and membrane interaction of the putative membrane anchor domains of prostaglandin I2 synthase and cytochrome P450 2C1.
Archives of biochemistry and biophysics 1998;352(1):78-84.
1998: Ke-He Ruan; Dawei Li; J Ji; Yue-Zhen Lin; X Gao
Structural characterization and topology of the second potential membrane anchor region in the thromboxane A2 synthase amino-terminal domain.
Biochemistry 1998;37(3):822-30.
1997: Song-Kun Shyue; Ke-He Ruan; Lee-Ho Wang; Kenneth K Wu
Prostacyclin synthase active sites. Identification by molecular modeling-guided site-directed mutagenesis.
The Journal of biological chemistry 1997;272(6):3657-62.
1996: Lee-Ho Wang; N Matijevic-Aleksic; P Y Hsu; Ke-He Ruan; Kenneth K Wu; Richard J Kulmacz
Identification of thromboxane A2 synthase active site residues by molecular modeling-guided site-directed mutagenesis.
The Journal of biological chemistry 1996;271(33):19970-5.
1996: Q Guo; Lee-Ho Wang; Ke-He Ruan; Richard J Kulmacz
Role of Val509 in time-dependent inhibition of human prostaglandin H synthase-2 cyclooxygenase activity by isoform-selective agents.
The Journal of biological chemistry 1996;271(32):19134-9.
1995: Y Ren; C Walker; D S Loose-Mitchell; J Deng; Ke-He Ruan; Richard J Kulmacz
Topology of prostaglandin H synthase-1 in the endoplasmic reticulum membrane.
Archives of biochemistry and biophysics 1995;323(1):205-14.
1995: Y Ren; Ke-He Ruan; C Walker; Richard J Kulmacz
Evaluation of prostaglandin H synthase-1 membrane topology and endoplasmic reticulum retention signals.
Advances in prostaglandin, thromboxane, and leukotriene research 1995;23():113-5.
1994: Ke-He Ruan; K Milfeld; Richard J Kulmacz; Kenneth K Wu
Comparison of the construction of a 3-D model for human thromboxane synthase using P450cam and BM-3 as templates: implications for the substrate binding pocket.
Protein engineering 1994;7(11):1345-51.
1994: Ke-He Ruan; P Li; Richard J Kulmacz; Kenneth K Wu
Characterization of the structure and membrane interaction of NH2-terminal domain of thromboxane A2 synthase.
The Journal of biological chemistry 1994;269(33):20938-42.
1993: Ke-He Ruan; Lee-Ho Wang; Kenneth K Wu; Richard J Kulmacz
Amino-terminal topology of thromboxane synthase in the endoplasmic reticulum.
The Journal of biological chemistry 1993;268(26):19483-90.
1993: Ke-He Ruan; Richard J Kulmacz; A Wilson; Kenneth K Wu
Highly sensitive fluorimetric enzyme immunoassay for prostaglandin H synthase solubilized from cultured cells.
Journal of immunological methods 1993;162(1):23-30.
1993: X M Xu; Kazuteru Ohashi; S K Sanduja; Ke-He Ruan; Lee-Ho Wang; Kenneth K Wu
Enhanced prostacyclin synthesis in endothelial cells by retrovirus-mediated transfer of prostaglandin H synthase cDNA.
The Journal of clinical investigation 1993;91(4):1843-9.
1992: Kazuteru Ohashi; Ke-He Ruan; Richard J Kulmacz; Kenneth K Wu; Lee-Ho Wang
Primary structure of human thromboxane synthase determined from the cDNA sequence.
The Journal of biological chemistry 1992;267(2):789-93.