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Christopher Rudd

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Anatomy

T-Lymphocytes

Physiology

Chemicals & Drugs

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Publications

TOP 3
Monika Raab; Xin Smith; Klaus Strebhardt; Yves Matthess; Christopher E Rudd
SKAP1 protein PH domain determines RapL membrane localization and Rap1 protein complex formation for T cell receptor (TCR) activation of LFA-1.
Hebin Liu; Marco A Purbhoo; Daniel M Davis; Christopher E Rudd
SH2 domain containing leukocyte phosphoprotein of 76-kDa (SLP-76) feedback regulation of ZAP-70 microclustering.
Hongyan Wang; Daina Lim; Christopher E Rudd
Immunopathologies linked to integrin signalling.

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All Publications

2011: Monika Raab; Xin Smith; Klaus Strebhardt; Yves Matthess; Christopher E Rudd
SKAP1 protein PH domain determines RapL membrane localization and Rap1 protein complex formation for T cell receptor (TCR) activation of LFA-1.
The Journal of biological chemistry 2011;286(34):29663-70.
2010: Hebin Liu; Marco A Purbhoo; Daniel M Davis; Christopher E Rudd
SH2 domain containing leukocyte phosphoprotein of 76-kDa (SLP-76) feedback regulation of ZAP-70 microclustering.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(22):10166-71.
2010: Hongyan Wang; Daina Lim; Christopher E Rudd
Immunopathologies linked to integrin signalling.
Seminars in immunopathology 2010;32(2):173-82.
2010: Hongyan Wang; Yuning Lu; Christopher E Rudd
SKAP1 is dispensable for chemokine-induced migration of primary T-cells.
Immunology letters 2010;128(2):148-53.
2010: Marco A Purbhoo; Hebin Liu; Stephane Oddos; Dylan Owen; Mark A A Neil; Sophie V Pageon; Paul M W French; Christopher E Rudd; Daniel M Davis
Dynamics of subsynaptic vesicles and surface microclusters at the immunological synapse.
Science signaling 2010;3(121):ra36.
2009: Hongyan Wang; Bin Wei; Georges Bismuth; Christopher E Rudd
SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(30):12436-41.
2009: Christopher E Rudd; Alison Taylor; Helga Schneider
CD28 and CTLA-4 coreceptor expression and signal transduction.
Immunological reviews 2009;229(1):12-26.
2009: Christopher E Rudd
CTLA-4 co-receptor impacts on the function of Treg and CD8+ T-cell subsets.
European journal of immunology 2009;39(3):687-90.
2008: Hongyan Wang; Christopher E Rudd
SKAP-55, SKAP-55-related and ADAP adaptors modulate integrin-mediated immune-cell adhesion.
Trends in cell biology 2008;18(10):486-93.
2008: Elke Valk; Christopher E Rudd; Helga Schneider
CTLA-4 trafficking and surface expression.
Trends in immunology 2008;29(6):272-9.
2008: Helga Schneider; Christopher E Rudd
CD28 and Grb-2, relative to Gads or Grap, preferentially co-operate with Vav1 in the activation of NFAT/AP-1 transcription.
Biochemical and biophysical research communications 2008;369(2):616-21.
2008: Christopher E Rudd
The reverse stop-signal model for CTLA4 function.
Nature reviews. Immunology 2008;8(2):153-60.
2008: Jos Downey; Andrew Smith; Helga Schneider; Nancy Hogg; Christopher E Rudd
TCR/CD3 mediated stop-signal is decoupled in T-cells from Ctla4 deficient mice.
Immunology letters 2008;115(1):70-2.
2008: Helga Schneider; Elke Valk; Rufina Leung; Christopher E Rudd
CTLA-4 activation of phosphatidylinositol 3-kinase (PI 3-K) and protein kinase B (PKB/AKT) sustains T-cell anergy without cell death.
PloS one 2008;3(12):e3842.
2008: Helga Schneider; Hongyan Wang; Monika Raab; Elke Valk; Xin Smith; Matt Lovatt; Zhonglin Wu; Braudel Maqueira-Iglesias; Klaus Strebhardt; Christopher E Rudd
Adaptor SKAP-55 binds p21 activating exchange factor RasGRP1 and negatively regulates the p21-ERK pathway in T-cells.
PloS one 2008;3(3):e1718.
2008: Helga Schneider; Xin Smith; Hebin Liu; Georges Bismuth; Christopher E Rudd
CTLA-4 disrupts ZAP70 microcluster formation with reduced T cell/APC dwell times and calcium mobilization.
European journal of immunology 2008;38(1):40-7.
2007: Bin Wei; Silvy da Rocha Dias; Hongyan Wang; Christopher E Rudd
CTL-associated antigen-4 ligation induces rapid T cell polarization that depends on phosphatidylinositol 3-kinase, Vav-1, Cdc42, and myosin light chain kinase.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(1):400-8.
2006: Elke Valk; Rufina Leung; Hyun Kang; Kazuyo Kaneko; Christopher E Rudd; Helga Schneider
T cell receptor-interacting molecule acts as a chaperone to modulate surface expression of the CTLA-4 coreceptor.
Immunity 2006;25(5):807-21.
2006: Joanne E Wood; Helga Schneider; Christopher E Rudd
TcR and TcR-CD28 engagement of protein kinase B (PKB/AKT) and glycogen synthase kinase-3 (GSK-3) operates independently of guanine nucleotide exchange factor VAV-1.
The Journal of biological chemistry 2006;281(43):32385-94.
2006: Helga Schneider; Jos Downey; Andrew Smith; Bernd Heinrich Zinselmeyer; Catherine Rush; James M Brewer; Bin Wei; Nancy Hogg; Paul Garside; Christopher E Rudd
Reversal of the TCR stop signal by CTLA-4.
Science (New York, N.Y.) 2006;313(5795):1972-5.
2006: Jonathan S Duke-Cohan; Hyun Kang; Hebin Liu; Christopher E Rudd
Regulation and function of SKAP-55 non-canonical motif binding to the SH3c domain of adhesion and degranulation-promoting adaptor protein.
The Journal of biological chemistry 2006;281(19):13743-50.
2006: Christopher E Rudd
Disabled receptor signaling and new primary immunodeficiency disorders.
The New England journal of medicine 2006;354(18):1874-7.
2006: Helga Schneider; Elke Valk; Silvy da Rocha Dias; Bin Wei; Christopher E Rudd
CTLA-4 regulation of T cell function via RAP-1-mediated adhesion.
Advances in experimental medicine and biology 2006;584():115-26.
2005: Beverley Wilkinson; Jocelyn S Downey; Christopher E Rudd
T-cell signalling and immune system disorders.
Expert reviews in molecular medicine 2005;7(29):1-29.
2005: Helga Schneider; Elke Valk; Silvy da Rocha Dias; Bin Wei; Christopher E Rudd
CTLA-4 up-regulation of lymphocyte function-associated antigen 1 adhesion and clustering as an alternate basis for coreceptor function.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(36):12861-6.
2005: Eun-Kyeong Jo; Hongyan Wang; Christopher E Rudd
An essential role for SKAP-55 in LFA-1 clustering on T cells that cannot be substituted by SKAP-55R.
The Journal of experimental medicine 2005;201(11):1733-9.
2004: Hongyan Wang; Fiona E McCann; John D Gordan; Xiang Wu; Monika Raab; Talat H Malik; Daniel M Davis; Christopher E Rudd
ADAP-SLP-76 binding differentially regulates supramolecular activation cluster (SMAC) formation relative to T cell-APC conjugation.
The Journal of experimental medicine 2004;200(8):1063-74.
2004: Stephen B Marley; John L Lewis; H Schneider; Christopher E Rudd; Myrtle Y Gordon
Phosphatidylinositol-3 kinase inhibitors reproduce the selective antiproliferative effects of imatinib on chronic myeloid leukaemia progenitor cells.
British journal of haematology 2004;125(4):500-11.
2004: Beverley Wilkinson; Hongyan Wang; Christopher E Rudd
Positive and negative adaptors in T-cell signalling.
Immunology 2004;111(4):368-74.
2003: Christopher E Rudd; Hongyan Wang
Hematopoietic adaptors in T-cell signaling: potential applications to transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2003;3(10):1204-10.
2003: Christopher E Rudd; Helga Schneider
Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling.
Nature reviews. Immunology 2003;3(7):544-56.
2003: Christopher E Rudd; Monika Raab
Independent CD28 signaling via VAV and SLP-76: a model for in trans costimulation.
Immunological reviews 2003;192():32-41.
2003: Hongyan Wang; Eun-Yi Moon; Abdallah Azouz; Xiang Wu; Andrew Smith; Helga Schneider; Nancy Hogg; Christopher E Rudd
SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates.
Nature immunology 2003;4(4):366-74.
2003: Li Yin; Helga Schneider; Christopher E Rudd
Short cytoplasmic SDYMNM segment of CD28 is sufficient to convert CTLA-4 to a positive signaling receptor.
Journal of leukocyte biology 2003;73(1):178-82.
2002: Helga Schneider; Didier A Mandelbrot; Rebecca J Greenwald; Fai Ng; Robert Lechler; Arlene H Sharpe; Christopher E Rudd
Cutting edge: CTLA-4 (CD152) differentially regulates mitogen-activated protein kinases (extracellular signal-regulated kinase and c-Jun N-terminal kinase) in CD4+ T cells from receptor/ligand-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(7):3475-9.
2002: Liping Geng; Christopher E Rudd
Signalling scaffolds and adaptors in T-cell immunity.
British journal of haematology 2002;116(1):19-27.
2001: L Geng; Christopher E Rudd
Adaptor ADAP (adhesion- and degranulation-promoting adaptor protein) regulates beta1 integrin clustering on mast cells.
Biochemical and biophysical research communications 2001;289(5):1135-40.
2001: M Martin; Helga Schneider; Abdallah Azouz; Christopher E Rudd
Cytotoxic T lymphocyte antigen 4 and CD28 modulate cell surface raft expression in their regulation of T cell function.
The Journal of experimental medicine 2001;194(11):1675-81.
2001: M Raab; S Pfister; Christopher E Rudd
CD28 signaling via VAV/SLP-76 adaptors: regulation of cytokine transcription independent of TCR ligation.
Immunity 2001;15(6):921-33.
2001: H Hu; Christopher E Rudd; Helga Schneider
Src kinases Fyn and Lck facilitate the accumulation of phosphorylated CTLA-4 and its association with PI-3 kinase in intracellular compartments of T-cells.
Biochemical and biophysical research communications 2001;288(3):573-8.
2001: L Geng; S Pfister; SK Kraeft; Christopher E Rudd
Adaptor FYB (Fyn-binding protein) regulates integrin-mediated adhesion and mediator release: differential involvement of the FYB SH3 domain.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(20):11527-32.
2001: Helga Schneider; Silvy da Rocha Dias; H Hu; Christopher E Rudd
A regulatory role for cytoplasmic YVKM motif in CTLA-4 inhibition of TCR signaling.
European journal of immunology 2001;31(7):2042-50.
2001: Christopher E Rudd
Lnk adaptor: novel negative regulator of B cell lymphopoiesis.
Science's STKE : signal transduction knowledge environment 2001;2001(85):pe1.
2001: Silvy da Rocha Dias; Christopher E Rudd
CTLA-4 blockade of antigen-induced cell death.
Blood 2001;97(4):1134-7.
2000: Christopher E Rudd; H Schneider
Lymphocyte signaling: Cbl sets the threshold for autoimmunity.
Current biology : CB 2000;10(9):R344-7.
2000: Helga Schneider; Christopher E Rudd
Tyrosine phosphatase SHP-2 binding to CTLA-4: absence of direct YVKM/YFIP motif recognition.
Biochemical and biophysical research communications 2000;269(1):279-83.
2000: H Schneider; B Guerette; C Guntermann; Christopher E Rudd
Resting lymphocyte kinase (Rlk/Txk) targets lymphoid adaptor SLP-76 in the cooperative activation of interleukin-2 transcription in T-cells.
The Journal of biological chemistry 2000;275(6):3835-40.
1999: L Geng; M Raab; Christopher E Rudd
Cutting edge: SLP-76 cooperativity with FYB/FYN-T in the Up-regulation of TCR-driven IL-2 transcription requires SLP-76 binding to FYB at Tyr595 and Tyr651.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(11):5753-7.
1999: J S Kennedy; M Raab; Christopher E Rudd
Signaling scaffolds in immune cells.
Cell calcium 1999;26(5):227-35.
1999: M Veale; M Raab; Z Li; A J da Silva; SK Kraeft; S Weremowicz; C C Morton; Christopher E Rudd
Novel isoform of lymphoid adaptor FYN-T-binding protein (FYB-130) interacts with SLP-76 and up-regulates interleukin 2 production.
The Journal of biological chemistry 1999;274(40):28427-35.
1999: Helga Schneider; M Martin; F A Agarraberes; L Yin; Iris Rapoport; Tomas Kirchhausen; Christopher E Rudd
Cytolytic T lymphocyte-associated antigen-4 and the TCR zeta/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(4):1868-79.
1999: M Raab; H Kang; A da Silva; X Zhu; Christopher E Rudd
FYN-T-FYB-SLP-76 interactions define a T-cell receptor zeta/CD3-mediated tyrosine phosphorylation pathway that up-regulates interleukin 2 transcription in T-cells.
The Journal of biological chemistry 1999;274(30):21170-9.
1999: Christopher E Rudd
Adaptors and molecular scaffolds in immune cell signaling.
Cell 1999;96(1):5-8.
1998: H Schneider; P L Schwartzberg; Christopher E Rudd
Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4.
Biochemical and biophysical research communications 1998;252(1):14-9.
1998: Christopher E Rudd
Lymphocyte signaling: adapting new adaptors.
Current biology : CB 1998;8(22):R805-8.
1998: J Liu; H Kang; M Raab; A J da Silva; SK Kraeft; Christopher E Rudd
FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(15):8779-84.
1998: D Céfaï; Helga Schneider; O Matangkasombut; H Kang; J Brody; Christopher E Rudd
CD28 receptor endocytosis is targeted by mutations that disrupt phosphatidylinositol 3-kinase binding and costimulation.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(5):2223-30.
1998: H H Kim; M Tharayil; Christopher E Rudd
Growth factor receptor-bound protein 2 SH2/SH3 domain binding to CD28 and its role in co-signaling.
The Journal of biological chemistry 1998;273(1):296-301.
1997: AJ da Silva; Z Li; C de Vera; E Canto; P Findell; Christopher E Rudd
Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(14):7493-8.
1997: AJ da Silva; M Raab; Z Li; Christopher E Rudd
TcR zeta/CD3 signal transduction in T-cells: downstream signalling via ZAP-70, SLP-76 and FYB.
Biochemical Society transactions 1997;25(2):361-6.
1997: A J da Silva; J M Rosenfield; I Mueller; A Bouton; H Hirai; Christopher E Rudd
Biochemical analysis of p120/130: a protein-tyrosine kinase substrate restricted to T and myeloid cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(5):2007-16.
1997: M Raab; AJ da Silva; P R Findell; Christopher E Rudd
Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2.
Immunity 1997;6(2):155-64.
1996: K R Solomon; Christopher E Rudd; Robert W Finberg
The association between glycosylphosphatidylinositol-anchored proteins and heterotrimeric G protein alpha subunits in lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(12):6053-8.
1996: Christopher E Rudd
Upstream-downstream: CD28 cosignaling pathways and T cell function.
Immunity 1996;4(6):527-34.
1996: M Raab; Christopher E Rudd
Hematopoietic cell phosphatase (HCP) regulates p56LCK phosphorylation and ZAP-70 binding to T cell receptor zeta chain.
Biochemical and biophysical research communications 1996;222(1):50-7.
1995: C Pignata; Kanteti V Prasad; Michael Hallek; Brian J Druker; Christopher E Rudd; M J Robertson; Jerome Ritz
Phosphorylation of src family lck tyrosine kinase following interleukin-12 activation of human natural killer cells.
Cellular immunology 1995;165(2):211-6.
1995: Y C Cai; D Cefai; Helga Schneider; M Raab; N Nabavi; Christopher E Rudd
Selective CD28pYMNM mutations implicate phosphatidylinositol 3-kinase in CD86-CD28-mediated costimulation.
Immunity 1995;3(4):417-26.
1995: M Raab; Y C Cai; SC Bunnell; S D Heyeck; Leslie J Berg; Christopher E Rudd
p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(19):8891-5.
1995: Helga Schneider; Y C Cai; Kanteti V Prasad; S E Shoelson; Christopher E Rudd
T cell antigen CD28 binds to the GRB-2/SOS complex, regulators of p21ras.
European journal of immunology 1995;25(4):1044-50.
1995: Helga Schneider; Y C Cai; D Cefai; M Raab; Christopher E Rudd
Mechanisms of CD28 signalling.
Research in immunology 1995;146(3):149-54.
1995: Helga Schneider; Kanteti V Prasad; S E Shoelson; Christopher E Rudd
CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells.
The Journal of experimental medicine 1995;181(1):351-5.
1994: Fernando A. Arosa; A J da Silva; I M Godinho; J C ter Steege; Graça Porto; Christopher E Rudd; Maria de Sousa
Decreased CD8-p56lck activity in peripheral blood T-lymphocytes from patients with hereditary haemochromatosis.
Scandinavian journal of immunology 1994;39(5):426-32.
1994: Christopher E Rudd; Ottmar Janssen; Y C Cai; A J da Silva; M Raab; Kanteti V Prasad
Two-step TCR zeta/CD3-CD4 and CD28 signaling in T cells: SH2/SH3 domains, protein-tyrosine and lipid kinases.
Immunology today 1994;15(5):225-34.
1994: M Raab; M Yamamoto; Christopher E Rudd
The T-cell antigen CD5 acts as a receptor and substrate for the protein-tyrosine kinase p56lck.
Molecular and cellular biology 1994;14(5):2862-70.
1994: Kanteti V Prasad; Y C Cai; M Raab; B Duckworth; L Cantley; S E Shoelson; Christopher E Rudd
T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(7):2834-8.
1994: R Kapeller; Kanteti V Prasad; Ottmar Janssen; W Hou; Brian Schaffhausen; Christopher E Rudd; Lewis C Cantley
Identification of two SH3-binding motifs in the regulatory subunit of phosphatidylinositol 3-kinase.
The Journal of biological chemistry 1994;269(3):1927-33.
1993: C Pignata; Kanteti V Prasad; M J Robertson; H Levine; Christopher E Rudd; Jerome Ritz
Fc gamma RIIIA-mediated signaling involves src-family lck in human natural killer cells.
Journal of immunology (Baltimore, Md. : 1950) 1993;151(12):6794-800.
1993: Kanteti V Prasad; R Kapeller; Ottmar Janssen; H Repke; J S Duke-Cohan; Lewis C Cantley; Christopher E Rudd
Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase.
Molecular and cellular biology 1993;13(12):7708-17.
1993: A J da Silva; Ottmar Janssen; Christopher E Rudd
T cell receptor zeta/CD3-p59fyn(T)-associated p120/130 binds to the SH2 domain of p59fyn(T).
The Journal of experimental medicine 1993;178(6):2107-13.
1993: Kanteti V Prasad; R Kapeller; Ottmar Janssen; J S Duke-Cohan; H Repke; Lewis C Cantley; Christopher E Rudd
Regulation of CD4-p56lck-associated phosphatidylinositol 3-kinase (PI 3-kinase) and phosphatidylinositol 4-kinase (PI 4-kinase).
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1993;342(1299):35-42.
1993: Christopher E Rudd; Ottmar Janssen; Kanteti V Prasad; M Raab; A da Silva; J C Telfer; M Yamamoto
src-related protein tyrosine kinases and their surface receptors.
Biochimica et biophysica acta 1993;1155(2):239-66.
1993: A J da Silva; Christopher E Rudd
A 72-kilodalton fyn-related polypeptide (p72fyn-R) binds to the antigen-receptor/CD3 (TcR/CD3) complex.
The Journal of biological chemistry 1993;268(22):16537-43.
1993: Kanteti V Prasad; Ottmar Janssen; R Kapeller; M Raab; Lewis C Cantley; Christopher E Rudd
Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(15):7366-70.
1993: Eric Vivier; A J da Silva; M Ackerly; H Levine; Christopher E Rudd; Paul Anderson
Association of a 70-kDa tyrosine phosphoprotein with the CD16: zeta: gamma complex expressed in human natural killer cells.
European journal of immunology 1993;23(8):1872-6.
1993: D M Rothstein; A da Silva; K Sugita; M Yamamoto; Kanteti V Prasad; Chikao Morimoto; Stuart F Schlossman; Christopher E Rudd
Human CD4/CD45RA+ and CD4/CD45RA- T cell subsets express CD4-p56lck complexes, CD4-associated lipid kinases, TCR/CD3-p59fyn complexes, and share similar tyrosine kinase substrates.
International immunology 1993;5(4):409-18.
1992: A J da Silva; M Yamamoto; C H Zalvan; Christopher E Rudd
Engagement of the TcR/CD3 complex stimulates p59fyn(T) activity: detection of associated proteins at 72 and 120-130 kD.
Molecular immunology 1992;29(12):1417-25.
1992: Kanteti V Prasad; Christopher E Rudd
A Raf-1-related p110 polypeptide associates with the CD4-p56lck complex in T cells.
Molecular and cellular biology 1992;12(11):5260-7.
1992: H Repke; E Barber; S Ulbricht; Klaus Buchner; F Hucho; R Kopp; H Scholz; Christopher E Rudd; W A Haseltine
Ganglioside-induced CD4 endocytosis occurs independent of serine phosphorylation and is accompanied by dissociation of P56lck.
Journal of immunology (Baltimore, Md. : 1950) 1992;149(8):2585-91.
1992: K E Burgess; M Yamamoto; Kanteti V Prasad; Christopher E Rudd
CD5 acts as a tyrosine kinase substrate within a receptor complex comprising T-cell receptor zeta chain/CD3 and protein-tyrosine kinases p56lck and p59fyn.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(19):9311-5.
1991: J C Telfer; Christopher E Rudd
A 32-kD GTP-binding protein associated with the CD4-p56lck and CD8-p56lck T cell receptor complexes.
Science (New York, N.Y.) 1991;254(5030):439-41.
1991: K E Burgess; A D Odysseos; C Zalvan; Brian J Druker; Paul Anderson; Stuart F Schlossman; Christopher E Rudd
Biochemical identification of a direct physical interaction between the CD4:p56lck and Ti(TcR)/CD3 complexes.
European journal of immunology 1991;21(7):1663-8.
1991: Christopher E Rudd; E K Barber; K E Burgess; J Y Hahn; A D Odysseos; M S Sy; Stuart F Schlossman
Molecular analysis of the interaction of p56lck with the CD4 and CD8 antigens.
Advances in experimental medicine and biology 1991;292():85-96.
1990: Christopher E Rudd
CD4, CD8 and the TCR-CD3 complex: a novel class of protein-tyrosine kinase receptor.
Immunology today 1990;11(11):400-6.
1989: Chikao Morimoto; Y Torimoto; G Levinson; Christopher E Rudd; M Schrieber; N H Dang; Norman L Letvin; Stuart F Schlossman
1F7, a novel cell surface molecule, involved in helper function of CD4 cells.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(11):3430-9.
1989: Christopher E Rudd; Paul Anderson; Chikao Morimoto; Michel Streuli; Stuart F Schlossman
Molecular interactions, T-cell subsets and a role of the CD4/CD8:p56lck complex in human T-cell activation.
Immunological reviews 1989;111():225-66.
1989: E K Barber; J D Dasgupta; Stuart F Schlossman; J M Trevillyan; Christopher E Rudd
The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(9):3277-81.
1989: T Takeuchi; Christopher E Rudd; S Tanaka; D M Rothstein; Stuart F Schlossman; Chikao Morimoto
Functional characterization of the CD45R (2H4) molecule on CD8 (T8) cells in the autologous mixed lymphocyte reaction system.
European journal of immunology 1989;19(4):747-55.
1989: T Takeuchi; Christopher E Rudd; T F Tedder; Stuart F Schlossman; Chikao Morimoto
Amplification of suppressor inducer pathway with monoclonal antibody, anti-2H4, identifying a novel epitope of the common leukocyte antigen/T200 antigen.
Cellular immunology 1989;118(1):68-84.
1988: Christopher E Rudd; J M Trevillyan; J D Dasgupta; L L Wong; Stuart F Schlossman
The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(14):5190-4.
1988: Chikao Morimoto; T Matsuyama; Christopher E Rudd; A Forsgren; Norman L Letvin; Stuart F Schlossman
Role of the 2H4 molecule in the activation of suppressor inducer function.
European journal of immunology 1988;18(5):731-7.
1988: Chikao Morimoto; Christopher E Rudd; Norman L Letvin; M Hagan; Stuart F Schlossman
2H1--a novel antigen involved in T lymphocyte triggering.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(7):2165-70.
1987: Chikao Morimoto; Christopher E Rudd; Norman L Letvin; Stuart F Schlossman
A novel epitope of the LFA-1 antigen which can distinguish killer effector and suppressor cells in human CD8 cells.
Nature 1987;330(6147):479-82.
1987: Christopher E Rudd; Chikao Morimoto; L L Wong; Stuart F Schlossman
The subdivision of the T4 (CD4) subset on the basis of the differential expression of L-C/T200 antigens.
The Journal of experimental medicine 1987;166(6):1758-73.
1986: C Morimoto; N L Letvin; Christopher E Rudd; M Hagan; T Takeuchi; S F Schlossman
The role of the 2H4 molecule in the generation of suppressor function in Con A-activated T cells.
Journal of immunology (Baltimore, Md. : 1950) 1986;137(10):3247-53.