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Lenhard Rudolph

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TOP 3
Kerstin Bauer; Si Tao; K Lenhard Rudolph
Telomere stability--Wnt it or lose it.
Claire Falandry; Eric Gilson; K Lenhard Rudolph
Are aging biomarkers clinically relevant in oncogeriatrics?
Cagatay Günes; K Lenhard Rudolph
The role of telomeres in stem cells and cancer.

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All Publications

2013: Kerstin Bauer; Si Tao; K Lenhard Rudolph
Telomere stability--Wnt it or lose it.
EMBO reports 2013;14(4):297-8.
2013: Claire Falandry; Eric Gilson; K Lenhard Rudolph
Are aging biomarkers clinically relevant in oncogeriatrics?
Critical reviews in oncology/hematology 2013;85(3):257-65.
2013: Cagatay Günes; K Lenhard Rudolph
The role of telomeres in stem cells and cancer.
Cell 2013;152(3):390-3.
2013: Sarah Schwitalla; Julia Slotta-Huspenina; Paul K Ziegler; Olivia Prazeres da Costa; Franz G Bader; Valentin Becker; Yvonne Begus-Nahrmann; David Horst; Irina Kerle; Thomas Kirchner; Rupert Langer; André Lechel; Alexander Meining; Markus F Neurath; K Lenhard Rudolph; Florian R Greten
Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors.
Cancer cell 2013;23(1):93-106.
2012: Biguang Tuo; Regina Engelhardt; Zhenyu Ju; Michael P Manns; Brigitte Riederer; K Lenhard Rudolph; Ursula Seidler
Telomere shortening is associated with reduced duodenal HCOFormula secretory but normal gastric acid secretory capacity in aging mice.
American journal of physiology. Gastrointestinal and liver physiology 2012;303(12):G1312-21.
2012: Tobias Sperka; Jianwei Wang; K Lenhard Rudolph
DNA damage checkpoints in stem cells, ageing and cancer.
Nature reviews. Molecular cell biology 2012;13(9):579-90.
2012: Stefan Tümpel; K Lenhard Rudolph
The role of telomere shortening in somatic stem cells and tissue aging: lessons from telomerase model systems.
Annals of the New York Academy of Sciences 2012;1266():28-39.
2012: Yvonne Begus-Nahrmann; Parisa Eshraghi; Melanie Grieb; Daniel Hartmann; Hans A Kestler; Johann Kraus; André Lechel; Han-Wong Lee; Volker Rasche; Annika Scheffold; Peter Schirmacher; K Lenhard Rudolph
Transient telomere dysfunction induces chromosomal instability and promotes carcinogenesis.
The Journal of clinical investigation 2012;122(6):2283-8.
2012: Zhangfa Song; Junling Zhang; Zhenyu Ju; K Lenhard Rudolph
Telomere dysfunctional environment induces loss of quiescence and inherent impairments of hematopoietic stem cell function.
Aging cell 2012;11(3):449-55.
2012: Sarah-Fee Katz; Hans A Kestler; Johann M Kraus; André Lechel; Birgit Liss; Anna C Obenauf; Yvonne Begus-Nahrmann; Johanna Duda; Parisa Eshraghi; Daniel Hartmann; Eva M Hoffmann; Peter Schirmacher; Michael R Speicher; K Lenhard Rudolph
Disruption of Trp53 in livers of mice induces formation of carcinomas with bilineal differentiation.
Gastroenterology 2012;142(5):1229-1239.e3.
2012: Ali Mirsaidi; Karin N Kleinhans; Markus Rimann; K Lenhard Rudolph; Martin Stauber; André N Tiaden; Peter J Richards
Telomere length, telomerase activity and osteogenic differentiation are maintained in adipose-derived stromal cells from senile osteoporotic SAMP6 mice.
Journal of tissue engineering and regenerative medicine 2012;6(5):378-90.
2012: Alexander Kleger; Johann M Kraus; André Lechel; Stefan Liebau; Qiong Lin; Komal Loya; Pallavi U Mahaddalkar; Tobias Cantz; Daniel Hartmann; Jin Young Joo; Sarah-Fee Katz; Hans A Kestler; Hans Schöler; Holm Zaehres; K Lenhard Rudolph
Increased reprogramming capacity of mouse liver progenitor cells, compared with differentiated liver cells, requires the BAF complex.
Gastroenterology 2012;142(4):907-17.
2012: Jianwei Wang; Torsten Wuestefeld; Lars Zender; Axel Schambach; Hubert Schrezenmeier; Qian Sun; Daniel Dauch; Anne Gompf; Alexander Gross; Luis Miguel Guachalla; Daniel Hartmann; Kai Hildner; Wolf-Karsten Hofmann; Hong Jiang; Zhenyu Ju; Hans A Kestler; André Lechel; Yohei Morita; Hiromitsu Nakauchi; K Lenhard Rudolph
A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage.
Cell 2012;148(5):1001-14.
2011: Jianwei Wang; Hartmut Geiger; K Lenhard Rudolph
Immunoaging induced by hematopoietic stem cell aging.
Current opinion in immunology 2011;23(4):532-6.
2011: Harshvardhan Rolyan; Yvonne Begus-Nahrmann; Knut Biber; Annette Heinrich; Sabine M Hölter; Britta Heike Langkopf; Dieter Chichung Lie; Birgit Liss; Annika Scheffold; Dietmar Rudolf Thal; Daniela M Vogt-Weisenhorn; Wolfgang Wurst; K Lenhard Rudolph
Telomere shortening reduces Alzheimer's disease amyloid pathology in mice.
Brain : a journal of neurology 2011;134(Pt 7):2044-56.
2011: Hüseyin Sirma; Julia M Weise; Britta Witt; Lars Zender; Mukesh Kumar; André Lechel; Jitendra K Meena; K Lenhard Rudolph; Vadim Sakk; Satyanarayana Ande; Christiane Guguen-Guillouzo; Cagatay Günes
The promoter of human telomerase reverse transcriptase is activated during liver regeneration and hepatocyte proliferation.
Gastroenterology 2011;141(1):326-37, 337.e1-3.
2011: Parisa Eshraghi; K Lenhard Rudolph
Lineage-specific pleiotropy in immune aging.
Blood 2011;117(12):3250-1.
2011: Luis Miguel Guachalla; K Lenhard Rudolph
The GAPs between hepatocellular carcinoma and RAS.
Journal of hepatology 2011;54(2):191-2.
2011: Masami Watabe-Rudolph; Marc-Oliver Scheithauer; Dietmar Rudolf Thal; Yvonne Begus-Nahrmann; André Lechel; Gerhard Rettinger; Harshvardhan Rolyan; K Lenhard Rudolph
Telomere shortening impairs regeneration of the olfactory epithelium in response to injury but not under homeostatic conditions.
PloS one 2011;6(11):e27801.
2011: Guido von Figura; Martin Wagner; Kodandaramireddy Nalapareddy; Daniel Hartmann; Alexander Kleger; Luis Miguel Guachalla; Harshvardhan Rolyan; Guido Adler; K Lenhard Rudolph
Regeneration of the exocrine pancreas is delayed in telomere-dysfunctional mice.
PloS one 2011;6(2):e17122.
2010: Luis Miguel Guachalla; K Lenhard Rudolph
ROS induced DNA damage and checkpoint responses: influences on aging?
Cell cycle (Georgetown, Tex.) 2010;9(20):4058-60.
2010: Doreen Kuhlow; Simone Florian; Guido von Figura; Sandra Weimer; Nadja Schulz; Klaus J Petzke; Kim Zarse; Andreas F H Pfeiffer; K Lenhard Rudolph; Michael Ristow
Telomerase deficiency impairs glucose metabolism and insulin secretion.
Aging 2010;2(10):650-8.
2010: Kodandaramireddy Nalapareddy; Aaheli Roy Choudhury; Anne Gompf; Zhenyu Ju; Satyavani Ravipati; Thomas Leucht; André Lechel; K Lenhard Rudolph
CHK2-independent induction of telomere dysfunction checkpoints in stem and progenitor cells.
EMBO reports 2010;11(8):619-25.
2010: Giovanna Giannotti; Carola Doerries; Pavani S Mocharla; Maja F Mueller; Ferdinand H Bahlmann; Tibor Horvàth; Hong Jiang; Sajoscha A Sorrentino; Nora Steenken; Costantina Manes; Mario Marzilli; K Lenhard Rudolph; Thomas F Lüscher; Helmut Drexler; Ulf Landmesser
Impaired endothelial repair capacity of early endothelial progenitor cells in prehypertension: relation to endothelial dysfunction.
Hypertension 2010;55(6):1389-97.
2010: Zhangfa Song; Jianwei Wang; Luis Miguel Guachalla; Grzegorz Terszowski; Hans-Reimer Rodewald; Zhenyu Ju; K Lenhard Rudolph
Alterations of the systemic environment are the primary cause of impaired B and T lymphopoiesis in telomere-dysfunctional mice.
Blood 2010;115(8):1481-9.
2009: Guido von Figura; Daniel Hartmann; Zhangfa Song; K Lenhard Rudolph
Role of telomere dysfunction in aging and its detection by biomarkers.
Journal of molecular medicine (Berlin, Germany) 2009;87(12):1165-71.
2009: Yvonne Begus-Nahrmann; André Lechel; Anna C Obenauf; Kodandaramireddy Nalapareddy; Elvira Peit; Eva Hoffmann; Falk Schlaudraff; Birgit Liss; Peter Schirmacher; Hans A Kestler; Esther Danenberg; Nick Barker; Hans Clevers; Michael R Speicher; K Lenhard Rudolph
p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice.
Nature genetics 2009;41(10):1138-43.
2009: K Lenhard Rudolph; Daniel Hartmann; Oliver G Opitz
Telomere dysfunction and DNA damage checkpoints in diseases and cancer of the gastrointestinal tract.
Gastroenterology 2009;137(3):754-62.
2009: Hartmut Geiger; K Lenhard Rudolph
Aging in the lympho-hematopoietic stem cell compartment.
Trends in immunology 2009;30(7):360-5.
2009: Lars Zender; K Lenhard Rudolph
Keeping your senescent cells under control.
Aging 2009;1(5):438-41.
2009: Luis Miguel Guachalla; Zhenyu Ju; Rafal Koziel; Guido von Figura; Zhangfa Song; Markus Fusser; Bernd Epe; Pidder Jansen-Durr; K Lenhard Rudolph
Sod2 haploinsufficiency does not accelerate aging of telomere dysfunctional mice.
Aging 2009;1(3):303-15.
2009: Guido von Figura; K Lenhard Rudolph
[[Cancer and aging--biological mechanisms].
Onkologie 2009;32 Suppl 3():34-8.
2009: Luis Miguel Guachalla; K Lenhard Rudolph
Improve organ health by chewing up old proteins?
Hepatology (Baltimore, Md.) 2009;49(1):330-2.
2008: Kodandaramireddy Nalapareddy; Hong Jiang; Luis Miguel Guachalla Gutierrez; K Lenhard Rudolph
Determining the influence of telomere dysfunction and DNA damage on stem and progenitor cell aging: what markers can we use?
Experimental gerontology 2008;43(11):998-1004.
2008: Hong Jiang; Eric Schiffer; Zhangfa Song; Jianwei Wang; Petra Zürbig; Kathrin Thedieck; Suzette Moes; Heike Bantel; Nadja Saal; Justyna Jantos; Meiken Brecht; Paul Jenö; Michael N Hall; Klaus Hager; Michael P Manns; Hartmut Hecker; Arnold Ganser; Konstanze Döhner; Andrzej Bartke; Christoph Meissner; Mischak Harald; Zhenyu Ju; K Lenhard Rudolph
Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(32):11299-304.
2008: Christian Templin; Daniel Kotlarz; Chozhavendan Rathinam; Cornelia Rudolph; Sonja Schätzlein; Kodanda Ramireddy; K Lenhard Rudolph; Brigitte Schlegelberger; Christoph Klein; Helmut Drexler
Establishment of immortalized multipotent hematopoietic progenitor cell lines by retroviral-mediated gene transfer of beta-catenin.
Experimental hematology 2008;36(2):204-15.
2007: Sonja Schaetzlein; N R Kodandaramireddy; Zhenyu Ju; André Lechel; Anna Stepczynska; Dana R Lilli; Alan B Clark; Cornelia Rudolph; Florian Kuhnel; Kaichun Wei; Brigitte Schlegelberger; Peter Schirmacher; Thomas A Kunkel; Roger A. Greenberg; Winfried Edelmann; K Lenhard Rudolph
Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice.
Cell 2007;130(5):863-77.
2007: Hashem B El-Serag; K Lenhard Rudolph
Hepatocellular carcinoma: epidemiology and molecular carcinogenesis.
Gastroenterology 2007;132(7):2557-76.
2007: Zhenyu Ju; Hong Jiang; Maike Jaworski; Chozhavendan Rathinam; Anne Gompf; Christoph Klein; Andreas Trumpp; K Lenhard Rudolph
Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment.
Nature medicine 2007;13(6):742-7.
2007: Zhenyu Ju; Aaheli Roy Choudhury; K Lenhard Rudolph
A dual role of p21 in stem cell aging.
Annals of the New York Academy of Sciences 2007;1100():333-44.
2007: André Lechel; Henne Holstege; Yvonne Begus; Andrea Schienke; Kenji Kamino; Ulrich Lehmann; Stefan Kubicka; Peter Schirmacher; Jos Jonkers; K Lenhard Rudolph
Telomerase deletion limits progression of p53-mutant hepatocellular carcinoma with short telomeres in chronic liver disease.
Gastroenterology 2007;132(4):1465-75.
2007: Ruben R Plentz; Young Nyun Park; André Lechel; Haeryoung Kim; Friederike Nellessen; Britta Heike Eva Langkopf; Ludwig Wilkens; Annarita Destro; Barbara Fiamengo; Michael Peter Manns; Massimo Roncalli; K Lenhard Rudolph
Telomere shortening and inactivation of cell cycle checkpoints characterize human hepatocarcinogenesis.
Hepatology (Baltimore, Md.) 2007;45(4):968-76.
2007: Aaheli Roy Choudhury; Zhenyu Ju; Meta W Djojosubroto; Andrea Schienke; André Lechel; Sonja Schaetzlein; Hong Jiang; Anna Stepczynska; Chunfang Wang; Jan Buer; Han-Woong Lee; Thomas von Zglinicki; Arnold Ganser; Peter Schirmacher; Hiromitsu Nakauchi; K Lenhard Rudolph
Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation.
Nature genetics 2007;39(1):99-105.
2006: Ruben R Plentz; K Lenhard Rudolph
[Telomere dysfunction and telomerase: implications for human pathophysiology during ageing and chronic diseases].
Deutsche medizinische Wochenschrift (1946) 2006;131(38):2087-90.
2006: Zhenyu Ju; K Lenhard Rudolph
Telomeres and telomerase in cancer stem cells.
European journal of cancer (Oxford, England : 1990) 2006;42(9):1197-203.
2005: Meta W Djojosubroto; Allison C Chin; Ning Go; Sonja Schaetzlein; Michael P Manns; Sergei Gryaznov; Calvin B Harley; K Lenhard Rudolph
Telomerase antagonists GRN163 and GRN163L inhibit tumor growth and increase chemosensitivity of human hepatoma.
Hepatology (Baltimore, Md.) 2005;42(5):1127-36.
2005: Ruben R Plentz; Brigitte Schlegelberger; Peer Flemming; Michael Gebel; Hans Kreipe; Michael P Manns; K Lenhard Rudolph; Ludwig Wilkens
Telomere shortening correlates with increasing aneuploidy of chromosome 8 in human hepatocellular carcinoma.
Hepatology (Baltimore, Md.) 2005;42(3):522-6.
2005: Ruben R Plentz; Hans L Tillmann; Stefan Kubicka; Jörg S Bleck; Michael Gebel; Michael P Manns; K Lenhard Rudolph
Hepatocellular carcinoma and octreotide: treatment results in prospectively assigned patients with advanced tumor and cirrhosis stage.
Journal of gastroenterology and hepatology 2005;20(9):1422-8.
2005: Thomas Wirth; Florian Kühnel; Bettina Fleischmann-Mundt; Norman Woller; Meta W Djojosubroto; K Lenhard Rudolph; Michael Manns; Lars Zender; Stefan Kubicka
Telomerase-dependent virotherapy overcomes resistance of hepatocellular carcinomas against chemotherapy and tumor necrosis factor-related apoptosis-inducing ligand by elimination of Mcl-1.
Cancer research 2005;65(16):7393-402.
2005: Ruben R Plentz; Tim O Lankisch; Murat Bastürk; Corinnna C M Müller; Timm Kirchhoff; Michael Gebel; Jörg S Bleck; Stefan Kubicka; Michael P Manns; Peter N Meier; K Lenhard Rudolph
Prospective analysis of German patients with hepatocellular carcinoma undergoing transcatheter arterial chemoembolization with or without prophylactic antibiotic therapy.
Journal of gastroenterology and hepatology 2005;20(7):1134-6.
2005: K Lenhard Rudolph
Telomeres and telomerase influence the course of human diseases, aging and carcinogenesis.
Current molecular medicine 2005;5(2):133-4.
2005: André Lechel; Ande Satyanarayana; Zhenyu Ju; Ruben R Plentz; Sonja Schaetzlein; Cornelia Rudolph; Ludwig Wilkens; Stefan Wiemann; Gabriele Saretzki; Nisar P Malek; Michael P Manns; Jan Buer; K Lenhard Rudolph
The cellular level of telomere dysfunction determines induction of senescence or apoptosis in vivo.
EMBO reports 2005;6(3):275-81.
2005: Stefan Wiemann; Ande Satyanarayana; Jan Buer; Kenji Kamino; Michael P Manns; K Lenhard Rudolph
Contrasting effects of telomere shortening on organ homeostasis, tumor suppression, and survival during chronic liver damage.
Oncogene 2005;24(9):1501-9.
2005: Hans L Tillmann; Michael P Manns; K Lenhard Rudolph
Merging models of hepatitis C virus pathogenesis.
Seminars in liver disease 2005;25(1):84-92.
2005: Roger A. Greenberg; K Lenhard Rudolph
Telomere structural dynamics in genome integrity control and carcinogenesis.
Advances in experimental medicine and biology 2005;570():311-41.
2005: Sonja Schaetzlein; K Lenhard Rudolph
Telomere length regulation during cloning, embryogenesis and ageing.
Reproduction, fertility, and development 2005;17(1-2):85-96.
2004: Ande Satyanarayana; K Lenhard Rudolph
p16 and ARF: activation of teenage proteins in old age.
The Journal of clinical investigation 2004;114(9):1237-40.
2004: Ande Satyanarayana; Robert Geffers; Michael P Manns; Jan Buer; K Lenhard Rudolph
Gene expression profile at the G1/S transition of liver regeneration after partial hepatectomy in mice.
Cell cycle (Georgetown, Tex.) 2004;3(11):1405-17.
2004: Ande Satyanarayana; Michael P Manns; K Lenhard Rudolph
Telomeres, telomerase and cancer: an endless search to target the ends.
Cell cycle (Georgetown, Tex.) 2004;3(9):1138-50.
2004: André Lechel; Michael P Manns; K Lenhard Rudolph
Telomeres and telomerase: new targets for the treatment of liver cirrhosis and hepatocellular carcinoma.
Journal of hepatology 2004;41(3):491-7.
2004: Ande Satyanarayana; Michael P Manns; K Lenhard Rudolph
Telomeres and telomerase: a dual role in hepatocarcinogenesis.
Hepatology (Baltimore, Md.) 2004;40(2):276-83.
2004: Ruben R Plentz; Martin Caselitz; Jörg S Bleck; Michael Gebel; Peer Flemming; Stefan Kubicka; Michael P Manns; K Lenhard Rudolph
Hepatocellular telomere shortening correlates with chromosomal instability and the development of human hepatoma.
Hepatology (Baltimore, Md.) 2004;40(1):80-6.
2004: Ande Satyanarayana; Roger A. Greenberg; Sonja Schaetzlein; Jan Buer; Kenkichi Masutomi; William C Hahn; S Zimmermann; U Martens; Michael P Manns; K Lenhard Rudolph
Mitogen stimulation cooperates with telomere shortening to activate DNA damage responses and senescence signaling.
Molecular and cellular biology 2004;24(12):5459-74.
2004: Sonja Schaetzlein; Andrea Lucas-Hahn; Erika Lemme; Wilfried Kues; Martina Dorsch; Michael P Manns; Heiner Niemann; K Lenhard Rudolph
Telomere length is reset during early mammalian embryogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(21):8034-8.
2003: Ruben R Plentz; Stefan Wiemann; Peer Flemming; Peter N Meier; Stefan Kubicka; Hans Kreipe; Michael P Manns; K Lenhard Rudolph
Telomere shortening of epithelial cells characterises the adenoma-carcinoma transition of human colorectal cancer.
Gut 2003;52(9):1304-7.
2003: Paraskevi A Farazi; Jonathan Glickman; Shan Jiang; Alice Yu; K Lenhard Rudolph; Ronald A DePinho
Differential impact of telomere dysfunction on initiation and progression of hepatocellular carcinoma.
Cancer research 2003;63(16):5021-7.
2003: Ande Satyanarayana; Stefan Wiemann; Jan Buer; Jörg Lauber; Kurt E J Dittmar; T Wüstefeld; M A Blasco; Michael P Manns; K Lenhard Rudolph
Telomere shortening impairs organ regeneration by inhibiting cell cycle re-entry of a subpopulation of cells.
The EMBO journal 2003;22(15):4003-13.
2003: Thomas Wirth; Lars Zender; Bernd Schulte; Bettina Mundt; Ruben R Plentz; K Lenhard Rudolph; Michael Manns; Stefan Kubicka; Florian Kühnel
A telomerase-dependent conditionally replicating adenovirus for selective treatment of cancer.
Cancer research 2003;63(12):3181-8.
2003: Meta W Djojosubroto; Yoon Sik Choi; Han-Woong Lee; K Lenhard Rudolph
Telomeres and telomerase in aging, regeneration and cancer.
Molecules and cells 2003;15(2):164-75.
2002: M Watabe-Rudolph; K Lenhard Rudolph; Thomas Averbeck; Thomas Buhr; Thomas Lenarz; Timo Stöver
Telomerase activity, telomere length, and apoptosis: a comparison between acquired cholesteatoma and squamous cell carcinoma.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 2002;23(5):793-8.
2002: Stefan Wiemann; Ande Satyanarayana; Martina Tsahuridu; Hans L Tillmann; Lars Zender; Jürgen Klempnauer; Peer Flemming; Sonia Franco; Maria A Blasco; Michael P Manns; K Lenhard Rudolph
Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(9):935-42.
2002: Masao Omata; Yoshiyuki Dan; Bruno Daniele; Ruben R Plentz; K Lenhard Rudolph; Michael Manns; Teerha Piratvisuth; Ding S Chen; Ryosuke Tateishi; Anuchit Chutaputti
Clinical features, etiology, and survival of hepatocellular carcinoma among different countries.
Journal of gastroenterology and hepatology 2002;17 Suppl():S40-9.
2002: Stefan Kubicka; Christiane Claas; Sven Staab; Florian Kühnel; Lars Zender; Christian Trautwein; Siegfried Wagner; K Lenhard Rudolph; Michael Manns
p53 mutation pattern and expression of c-erbB2 and c-met in gastric cancer: relation to histological subtypes, Helicobacter pylori infection, and prognosis.
Digestive diseases and sciences 2002;47(1):114-21.
2001: K Lenhard Rudolph; M Millard; Marcus W Bosenberg; Ronald A DePinho
Telomere dysfunction and evolution of intestinal carcinoma in mice and humans.
Nature genetics 2001;28(2):155-9.
2001: Stefan Kubicka; K Lenhard Rudolph; MK Tietze; M Lorenz; Michael P Manns
Phase II study of systemic gemcitabine chemotherapy for advanced unresectable hepatobiliary carcinomas.
Hepato-gastroenterology 2001;48(39):783-9.
2001: K H Lee; K Lenhard Rudolph; Y J Ju; Roger A. Greenberg; Linda Cannizzaro; Lynda Chin; Sarah R Weiler; Ronald A DePinho
Telomere dysfunction alters the chemotherapeutic profile of transformed cells.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(6):3381-6.
2001: Stefan Kubicka; Florian Kühnel; Peer Flemming; B Hain; Nikolina Kezmic; K Lenhard Rudolph; Michael P Manns; Peter N Meier
K-ras mutations in the bile of patients with primary sclerosing cholangitis.
Gut 2001;48(3):403-8.
2000: Kwok-Kin Wong; S Chang; Sarah R Weiler; S Ganesan; Jayanta Chaudhuri; C Zhu; Steven E Artandi; K Lenhard Rudolph; GJ Gottlieb; Lynda Chin; Frederick W Alt; Ronald A DePinho
Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation.
Nature genetics 2000;26(1):85-8.
2000: Stefan Kubicka; K Lenhard Rudolph; M Hanke; MK Tietze; Hans L Tillmann; Christian Trautwein; Michael P Manns
Hepatocellular carcinoma in Germany: a retrospective epidemiological study from a low-endemic area.
Liver 2000;20(4):312-8.
2000: K Lenhard Rudolph; S Chang; M Millard; N Schreiber-Agus; Ronald A DePinho
Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery.
Science (New York, N.Y.) 2000;287(5456):1253-8.
1999: Stefan Kubicka; Florian Kühnel; Lars Zender; K Lenhard Rudolph; Jörg Plümpe; Michael P Manns; Christian Trautwein
p53 represses CAAT enhancer-binding protein (C/EBP)-dependent transcription of the albumin gene. A molecular mechanism involved in viral liver infection with implications for hepatocarcinogenesis.
The Journal of biological chemistry 1999;274(45):32137-44.
1999: K Lenhard Rudolph; Christian Trautwein; Stefan Kubicka; T Rakemann; Matthias J Bahr; N Sedlaczek; Detlef Schuppan; Michael P Manns
Differential regulation of extracellular matrix synthesis during liver regeneration after partial hepatectomy in rats.
Hepatology (Baltimore, Md.) 1999;30(5):1159-66.
1999: K Lenhard Rudolph; S Chang; H W Lee; M Blasco; GJ Gottlieb; Carol W Greider; Ronald A DePinho
Longevity, stress response, and cancer in aging telomerase-deficient mice.
Cell 1999;96(5):701-12.