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Zaverio Ruggeri

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David Habart; Diane J Nugent; Zaverio M Ruggeri; Yann Cheli; Thomas J Kunicki
Conditional knockout of integrin α2β1 in murine megakaryocytes leads to reduced mean platelet volume.
Yani Liu; Owen J T McCarty; Zaverio M Ruggeri; Garth W Tormoen; Aris Xie; Qi Yue; Yan Zhao; Todd Belcik; Brian P Davidson; Yoichi Inaba; Beat A Kaufmann; Jonathan R Lindner
Molecular imaging of inflammation and platelet adhesion in advanced atherosclerosis effects of antioxidant therapy with NADPH oxidase inhibition.
Vivian X Du; Rob Fijnheer; Johanna A Kremer-Hovinga; Zaverio M Ruggeri; Gwen van Os; Jacques Wollersheim; Philip G de Groot; Ilze Dienava-Verdoold; Bas de Laat
Indications for a protective function of beta2-glycoprotein I in thrombotic thrombocytopenic purpura.

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2013: David Habart; Diane J Nugent; Zaverio M Ruggeri; Yann Cheli; Thomas J Kunicki
Conditional knockout of integrin α2β1 in murine megakaryocytes leads to reduced mean platelet volume.
PloS one 2013;8(1):e55094.
2013: Yani Liu; Owen J T McCarty; Zaverio M Ruggeri; Garth W Tormoen; Aris Xie; Qi Yue; Yan Zhao; Todd Belcik; Brian P Davidson; Yoichi Inaba; Beat A Kaufmann; Jonathan R Lindner
Molecular imaging of inflammation and platelet adhesion in advanced atherosclerosis effects of antioxidant therapy with NADPH oxidase inhibition.
Circulation. Cardiovascular imaging 2013;6(1):74-82.
2012: Vivian X Du; Rob Fijnheer; Johanna A Kremer-Hovinga; Zaverio M Ruggeri; Gwen van Os; Jacques Wollersheim; Philip G de Groot; Ilze Dienava-Verdoold; Bas de Laat
Indications for a protective function of beta2-glycoprotein I in thrombotic thrombocytopenic purpura.
British journal of haematology 2012;159(1):94-103.
2012: Giovanni Sitia; Roberto Aiolfi; Francis V Chisari; Pietro Di Lucia; Antonio Esposito; Amleto Fiocchi; Matteo Iannacone; Marta Mainetti; Francesca Mingozzi; Zaverio M Ruggeri; Luca G Guidotti
Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(32):E2165-72.
2012: Nishit Doshi; Samir Mitragotri; Blanca Molins; Jennifer N Orje; Jeffrey W Smith; Zaverio M Ruggeri
Platelet mimetic particles for targeting thrombi in flowing blood.
Advanced materials (Deerfield Beach, Fla.) 2012;24(28):3864-9.
2012: Lea Scheppke; David J Shields; Sara M Weis; Alessandro Zarpellon; Jennifer J Hofmann; M Luisa Iruela-Arispe; Alona Merkulova; Eric A Murphy; Zaverio M Ruggeri; Tatiana V Byzova; David A Cheresh
Notch promotes vascular maturation by inducing integrin-mediated smooth muscle cell adhesion to the endothelial basement membrane.
Blood 2012;119(9):2149-58.
2011: Conglei Li; Pingguo Chen; John Freedman; Peter L Gross; Joseph W Jin; Sean Lang; Ran Ni; Siavash Piran; Adili Reheman; Zaverio M Ruggeri; Elisa K Simpson; Dianne E van der Wal; Jerry Ware; Alessandro Zarpellon; Guangheng Zhu; Heyu Ni
The maternal immune response to fetal platelet GPIbα causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies.
The Journal of clinical investigation 2011;121(11):4537-47.
2011: Christian Furlan Freguia; András Gruber; Patrizia Marchese; Zaverio M Ruggeri; Wolfram Ruf
P2X7 receptor signaling contributes to tissue factor-dependent thrombosis in mice.
The Journal of clinical investigation 2011;121(7):2932-44.
2011: Alessandro Zarpellon; Reha Celikel; James R Roberts; Richard McClintock; G Loredana Mendolicchio; Kevin L Moore; Hua Jing; Kottayil I Varughese; Zaverio M Ruggeri
Binding of alpha-thrombin to surface-anchored platelet glycoprotein Ib(alpha) sulfotyrosines through a two-site mechanism involving exosite I.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(21):8628-33.
2011: Susan L Cranmer; Katrina J Ashworth; Yu Yao; Michael C Berndt; Zaverio M Ruggeri; Robert K Andrews; Shaun P Jackson
High shear-dependent loss of membrane integrity and defective platelet adhesion following disruption of the GPIbα-filamin interaction.
Blood 2011;117(9):2718-27.
2011: G Loredana Mendolicchio; D Zavalloni; M Bacci; E Corrada; M Marconi; C Lodigiani; P Presbitero; L Rota; Zaverio M Ruggeri
Variable effect of P2Y12 inhibition on platelet thrombus volume in flowing blood.
Journal of thrombosis and haemostasis : JTH 2011;9(2):373-82.
2010: Zaverio M Ruggeri; Alessandro Zarpellon; James R Roberts; Richard A Mc Clintock; Hua Jing; G Loredana Mendolicchio
Unravelling the mechanism and significance of thrombin binding to platelet glycoprotein Ib.
Thrombosis and haemostasis 2010;104(5):894-902.
2010: Xiaofeng Cui; Delphine Dean; Zaverio M Ruggeri; Thomas Boland
Cell damage evaluation of thermal inkjet printed Chinese hamster ovary cells.
Biotechnology and bioengineering 2010;106(6):963-9.
2010: Wolfram Ruf; Zaverio M Ruggeri
Neutrophils release brakes of coagulation.
Nature medicine 2010;16(8):851-2.
2010: Ana Kasirer-Friede; Zaverio M Ruggeri; Sanford J Shattil
Role for ADAP in shear flow-induced platelet mechanotransduction.
Blood 2010;115(11):2274-82.
2010: Nana-Maria Heida; Maren Leifheit-Nestler; Marco R Schroeter; Jan-Peter Müller; I-Fen Cheng; Sarah Henkel; Anne Limbourg; Florian P Limbourg; Frauke Alves; James P Quigley; Zaverio M Ruggeri; Gerd Hasenfuss; Stavros Konstantinides; Katrin Schäfer
Leptin enhances the potency of circulating angiogenic cells via src kinase and integrin (alpha)vbeta5: implications for angiogenesis in human obesity.
Arteriosclerosis, thrombosis, and vascular biology 2010;30(2):200-6.
2009: Nancy A Turner; Leticia Nolasco; Zaverio M Ruggeri; Joel L Moake
Endothelial cell ADAMTS-13 and VWF: production, release, and VWF string cleavage.
Blood 2009;114(24):5102-11.
2009: Mario Mazzucato; Maria Rita Cozzi; Monica Battiston; Martine Jandrot-Perrus; Maurizio Mongiat; Patrizia Marchese; Thomas J Kunicki; Zaverio M Ruggeri; Luigi De Marco
Distinct spatio-temporal Ca2+ signaling elicited by integrin alpha2beta1 and glycoprotein VI under flow.
Blood 2009;114(13):2793-801.
2009: Laurent O Mosnier; Antonella Zampolli; Edward J Kerschen; Reto A Schuepbach; Yajnavalka Banerjee; José A Fernández; Xia V Yang; Matthias Riewald; Hartmut Weiler; Zaverio M Ruggeri; John H Griffin
Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant.
Blood 2009;113(23):5970-8.
2009: Amanda L Blasius; Katharina Brandl; Karine Crozat; Yu Xia; Kevin Khovananth; Philippe Krebs; Nora G Smart; Antonella Zampolli; Zaverio M Ruggeri; Bruce Beutler
Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(8):2706-11.
2009: Cosmo Godino; Loredana Mendolicchio; Filippo Figini; Azeem Latib; Andrew Sp Sharp; John Cosgrave; Giliola Calori; Michela Cera; Alaide Chieffo; Alfredo Castelli; Attilio Maseri; Zaverio M Ruggeri; Antonio Colombo
Comparison of VerifyNow-P2Y12 test and Flow Cytometry for monitoring individual platelet response to clopidogrel. What is the cut-off value for identifying patients who are low responders to clopidogrel therapy?
Thrombosis journal 2009;7():4.
2009: Zaverio M Ruggeri
Platelet adhesion under flow.
Microcirculation (New York, N.Y. : 1994) 2009;16(1):58-83.
2008: Yuichi Kamikubo; Claudia Dellas; David J Loskutoff; James P Quigley; Zaverio M Ruggeri
Contribution of leptin receptor N-linked glycans to leptin binding.
The Biochemical journal 2008;410(3):595-604.
2008: Yann Cheli; Deborah Jensen; Patrizia Marchese; David Habart; Timothy Wiltshire; Michael Cooke; José A Fernandez; Jerry Ware; Zaverio M Ruggeri; Thomas J Kunicki
The Modifier of hemostasis (Mh) locus on chromosome 4 controls in vivo hemostasis of Gp6-/- mice.
Blood 2008;111(3):1266-73.
2008: Matteo Iannacone; Giovanni Sitia; Masanori Isogawa; Jason K Whitmire; Patrizia Marchese; Francis V Chisari; Zaverio M Ruggeri; Luca G Guidotti
Platelets prevent IFN-alpha/beta-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(2):629-34.
2007: Brian Petrich; Patrizia Marchese; Zaverio M Ruggeri; Saskia Spiess; Rachel A M Weichert; Feng Ye; Ralph Tiedt; Radek C Skoda; Susan J Monkley; David R Critchley; Mark H Ginsberg
Talin is required for integrin-mediated platelet function in hemostasis and thrombosis.
The Journal of experimental medicine 2007;204(13):3103-11.
2007: Matteo Iannacone; Giovanni Sitia; Inigo Narvaiza; Zaverio M Ruggeri; Luca G Guidotti
Antiplatelet drug therapy moderates immune-mediated liver disease and inhibits viral clearance in mice infected with a replication-deficient adenovirus.
Clinical and vaccine immunology : CVI 2007;14(11):1532-5.
2007: Zaverio M Ruggeri
Von Willebrand factor: looking back and looking forward.
Thrombosis and haemostasis 2007;98(1):55-62.
2007: Zaverio M Ruggeri; G Loredana Mendolicchio
Adhesion mechanisms in platelet function.
Circulation research 2007;100(12):1673-85.
2007: Alessandra Casonato; Luigi De Marco; Lisa Gallinaro; Maryta Sztukowska; Mario Mazzuccato; Monica Battiston; Antonio Pagnan; Zaverio M Ruggeri
Altered von Willebrand factor subunit proteolysis and multimer processing associated with the Cys2362Phe mutation in the B2 domain.
Thrombosis and haemostasis 2007;97(4):527-33.
2007: Matteo Iannacone; Giovanni Sitia; Zaverio M Ruggeri; Luca G Guidotti
HBV pathogenesis in animal models: recent advances on the role of platelets.
Journal of hepatology 2007;46(4):719-26.
2007: Ana Kasirer-Friede; Barry Moran; Jennifer Nagrampa-Orje; Ken Swanson; Zaverio M Ruggeri; Burkhart Schraven; Benjamin G Neel; Gary A Koretzky; Sanford J Shattil
ADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists.
Blood 2007;109(3):1018-25.
2007: Zaverio M Ruggeri
The role of von Willebrand factor in thrombus formation.
Thrombosis research 2007;120 Suppl 1():S5-9.
2006: Wolfgang Bergmeier; Crystal L Piffath; Tobias Goerge; Stephen M Cifuni; Zaverio M Ruggeri; Jerry Ware; Denisa D Wagner
The role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(45):16900-5.
2006: Roberta Donadelli; Federica Banterla; Miriam Galbusera; Cristina Capoferri; Sara Bucchioni; Sara Gastoldi; Silvia Nosari; Giuseppe Monteferrante; Zaverio M Ruggeri; Elena Bresin; Friedrich Scheiflinger; Edoardo Rossi; Constantino Martinez; Rosanna Coppo; Giuseppe Remuzzi; Marina Noris
In-vitro and in-vivo consequences of mutations in the von Willebrand factor cleaving protease ADAMTS13 in thrombotic thrombocytopenic purpura.
Thrombosis and haemostasis 2006;96(4):454-64.
2006: Zaverio M Ruggeri; Jennifer N Orje; Rolf Habermann; Augusto B Federici; Armin J Reininger
Activation-independent platelet adhesion and aggregation under elevated shear stress.
Blood 2006;108(6):1903-10.
2006: Stavros Konstantinides; Jerry Ware; Patrizia Marchese; F Almus-Jacobs; David J Loskutoff; Zaverio M Ruggeri
Distinct antithrombotic consequences of platelet glycoprotein Ibalpha and VI deficiency in a mouse model of arterial thrombosis.
Journal of thrombosis and haemostasis : JTH 2006;4(9):2014-21.
2006: Armin J Reininger; Harry F G Heijnen; Hannah Schumann; Hanno M Specht; Wolfgang Schramm; Zaverio M Ruggeri
Mechanism of platelet adhesion to von Willebrand factor and microparticle formation under high shear stress.
Blood 2006;107(9):3537-45.
2006: Zaverio M Ruggeri
Platelet interactions with vessel wall components during thrombogenesis.
Blood cells, molecules & diseases 2006;36(2):145-7.
2006: Roberta Donadelli; Jennifer N Orje; Cristina Capoferri; Giuseppe Remuzzi; Zaverio M Ruggeri
Size regulation of von Willebrand factor-mediated platelet thrombi by ADAMTS13 in flowing blood.
Blood 2006;107(5):1943-50.
2006: Osamu Inoue; Katsue Suzuki-Inoue; Owen J T McCarty; Masaaki Moroi; Zaverio M Ruggeri; Thomas J Kunicki; Yukio Ozaki; Steve P Watson
Laminin stimulates spreading of platelets through integrin alpha6beta1-dependent activation of GPVI.
Blood 2006;107(4):1405-12.
2006: Janka Kisucka; Catherine E Butterfield; Dan G Duda; Sarah C Eichenberger; Simin Saffaripour; Jerry Ware; Zaverio M Ruggeri; Rakesh K Jain; Judah Folkman; Denisa D Wagner
Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(4):855-60.
2006: Shinya Goto; Noriko Tamura; Hideyuki Ishida; Zaverio M Ruggeri
Dependence of platelet thrombus stability on sustained glycoprotein IIb/IIIa activation through adenosine 5'-diphosphate receptor stimulation and cyclic calcium signaling.
Journal of the American College of Cardiology 2006;47(1):155-62.
2005: Matteo Iannacone; Giovanni Sitia; Masanori Isogawa; Patrizia Marchese; Maria G Castro; Pedro R Lowenstein; Francis V Chisari; Zaverio M Ruggeri; Luca G Guidotti
Platelets mediate cytotoxic T lymphocyte-induced liver damage.
Nature medicine 2005;11(11):1167-9.
2005: Nicolas Prévost; Donna S Woulfe; Hong Jiang; Timothy J Stalker; Patrizia Marchese; Zaverio M Ruggeri; Lawrence F Brass
Eph kinases and ephrins support thrombus growth and stability by regulating integrin outside-in signaling in platelets.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(28):9820-5.
2005: G Loredana Mendolicchio; Zaverio M Ruggeri
New perspectives on von Willebrand factor functions in hemostasis and thrombosis.
Seminars in hematology 2005;42(1):5-14.
2004: Frank A Baglia; Corie N Shrimpton; Jonas Emsley; Kouki Kitagawa; Zaverio M Ruggeri; José A López; Peter N Walsh
Factor XI interacts with the leucine-rich repeats of glycoprotein Ibalpha on the activated platelet.
The Journal of biological chemistry 2004;279(47):49323-9.
2004: Mario Mazzucato; Maria Rita Cozzi; Paola Pradella; Zaverio M Ruggeri; Luigi De Marco
Distinct roles of ADP receptors in von Willebrand factor-mediated platelet signaling and activation under high flow.
Blood 2004;104(10):3221-7.
2004: Ana Kasirer-Friede; Maria Rita Cozzi; Mario Mazzucato; Luigi De Marco; Zaverio M Ruggeri; Sanford J Shattil
Signaling through GP Ib-IX-V activates alpha IIb beta 3 independently of other receptors.
Blood 2004;103(9):3403-11.
2004: Kottayil I Varughese; Zaverio M Ruggeri; Reha Celikel
Platinum-induced space-group transformation in crystals of the platelet glycoprotein Ib alpha N-terminal domain.
Acta crystallographica. Section D, Biological crystallography 2004;60(Pt 3):405-11.
2004: Zaverio M Ruggeri; Zaverio M Ruggeri
Platelet and von Willebrand factor interactions at the vessel wall.
Hämostaseologie 2004;24(1):1-11.
2004: Sona Vasudevan; Reha Celikel; Zaverio M Ruggeri; Kottayil I Varughese; Thomas J Kunicki
A single amino acid change in the binding pocket alters specificity of an anti-integrin antibody AP7.4 as revealed by its crystal structure.
Blood cells, molecules & diseases 2004;32(1):176-81.
2004: Augusto B Federici; Maria Teresa Canciani; Ileana Forza; Pier Mannuccio Mannucci; Patrizia Marchese; Jerry Ware; Zaverio M Ruggeri
A sensitive ristocetin co-factor activity assay with recombinant glycoprotein Ibalpha for the diagnosis of patients with low von Willebrand factor levels.
Haematologica 2004;89(1):77-85.
2004: Zaverio M Ruggeri
Type IIB von Willebrand disease: a paradox explains how von Willebrand factor works.
Journal of thrombosis and haemostasis : JTH 2004;2(1):2-6.
2003: Kazunobu Kato; Taisuke Kanaji; Susan Russell; Thomas J Kunicki; Kenichi Furihata; Sachiko Kanaji; Patrizia Marchese; Armin J Reininger; Zaverio M Ruggeri; Jerry Ware
The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion.
Blood 2003;102(5):1701-7.
2003: Béatrice Hechler; Nadège Lenain; Patrizia Marchese; Catherine Vial; Véronique Heim; Monique Freund; Jean-Pierre Cazenave; Marco Cattaneo; Zaverio M Ruggeri; Richard Evans; Christian Gachet
A role of the fast ATP-gated P2X1 cation channel in thrombosis of small arteries in vivo.
The Journal of experimental medicine 2003;198(4):661-7.
2003: Reha Celikel; Richard McClintock; James R Roberts; G Loredana Mendolicchio; Jerry Ware; Kottayil I Varughese; Zaverio M Ruggeri
Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha.
Science (New York, N.Y.) 2003;301(5630):218-21.
2003: Zaverio M Ruggeri
Von Willebrand factor, platelets and endothelial cell interactions.
Journal of thrombosis and haemostasis : JTH 2003;1(7):1335-42.
2003: Zaverio M Ruggeri
Von Willebrand factor.
Current opinion in hematology 2003;10(2):142-9.
2003: Marco Cattaneo; Maddalena L Zighetti; Rossana Lombardi; Constantino Martinez; Anna Lecchi; Pamela B Conley; Jerry Ware; Zaverio M Ruggeri
Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleeding.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(4):1978-83.
2002: Jeffrey G Gaca; Aaron Lesher; Olcay Aksoy; Zaverio M Ruggeri; William Parker; R Duane Davis
The role of the porcine von Willebrand factor: baboon platelet interactions in pulmonary xenotransplantation.
Transplantation 2002;74(11):1596-603.
2002: Ulf Sjöbring; Ulrika Ringdahl; Zaverio M Ruggeri
Induction of platelet thrombi by bacteria and antibodies.
Blood 2002;100(13):4470-7.
2002: Zaverio M Ruggeri
Platelets in atherothrombosis.
Nature medicine 2002;8(11):1227-34.
2002: Mario Mazzucato; Paola Pradella; Maria Rita Cozzi; Luigi De Marco; Zaverio M Ruggeri
Sequential cytoplasmic calcium signals in a 2-stage platelet activation process induced by the glycoprotein Ibalpha mechanoreceptor.
Blood 2002;100(8):2793-800.
2002: Enrique Saldívar; Jennifer N Orje; Zaverio M Ruggeri
Tensile destruction test as an estimation of partial proteolysis in fibrin clots.
American journal of hematology 2002;71(2):119-27.
2002: Kottayil I Varughese; Reha Celikel; Zaverio M Ruggeri
Structure and function of the von Willebrand factor A1 domain.
Current protein & peptide science 2002;3(3):301-12.
2002: Ana Kasirer-Friede; Jerry Ware; Lijun Leng; Patrizia Marchese; Zaverio M Ruggeri; Sanford J Shattil
Lateral clustering of platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha IIbbeta 3.
The Journal of biological chemistry 2002;277(14):11949-56.
2002: Brian Savage; Jan J Sixma; Zaverio M Ruggeri
Functional self-association of von Willebrand factor during platelet adhesion under flow.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):425-30.
2001: Zaverio M Ruggeri; R Landolfi
Platelet function and arterial thrombosis.
Italian heart journal : official journal of the Italian Federation of Cardiology 2001;2(11):809-10.
2001: Thomas J Kunicki; Zaverio M Ruggeri
Platelet collagen receptors and risk prediction in stroke and coronary artery disease.
Circulation 2001;104(13):1451-3.
2001: Brian Savage; M Cattaneo; Zaverio M Ruggeri
Mechanisms of platelet aggregation.
Current opinion in hematology 2001;8(5):270-6.
2001: Heyu Ni; V Ramakrishnan; Zaverio M Ruggeri; Jessie M Papalia; David R Phillips; Denisa D Wagner
Increased thrombogenesis and embolus formation in mice lacking glycoprotein V.
Blood 2001;98(2):368-73.
2001: Gerald Soslau; Reiner Class; DA Morgan; C Foster; Susan T Lord; Patrizia Marchese; Zaverio M Ruggeri
Unique pathway of thrombin-induced platelet aggregation mediated by glycoprotein Ib.
The Journal of biological chemistry 2001;276(24):21173-83.
2001: Zaverio M Ruggeri
Structure of von Willebrand factor and its function in platelet adhesion and thrombus formation.
Best practice & research. Clinical haematology 2001;14(2):257-79.
2001: Brunhilde Felding-Habermann; Timothy E O'Toole; Jeffrey W Smith; Emilia Fransvea; Zaverio M Ruggeri; Mark H Ginsberg; Paul E Hughes; Nisar Pampori; Sanford J Shattil; Alan Saven; Barbara M Mueller
Integrin activation controls metastasis in human breast cancer.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(4):1853-8.
2001: Udayaditya Sen; Sona Vasudevan; G Subbarao; Richard McClintock; Reha Celikel; Zaverio M Ruggeri; Kottayil I Varughese
Crystal structure of the von Willebrand factor modulator botrocetin.
Biochemistry 2001;40(2):345-52.
2000: Zaverio M Ruggeri
Role of von Willebrand factor in platelet thrombus formation.
Annals of medicine 2000;32 Suppl 1():2-9.
2000: Patrick André; Cécile V Denis; Jerry Ware; Simin Saffaripour; Richard O Hynes; Zaverio M Ruggeri; Denisa D Wagner
Platelets adhere to and translocate on von Willebrand factor presented by endothelium in stimulated veins.
Blood 2000;96(10):3322-8.
2000: Reha Celikel; Zaverio M Ruggeri; Kottayil I Varughese
von Willebrand factor conformation and adhesive function is modulated by an internalized water molecule.
Nature structural biology 2000;7(10):881-4.
2000: FI Pareti; A Lattuada; Caterina Bressi; M Zanobini; A Sala; A Steffan; Zaverio M Ruggeri
Proteolysis of von Willebrand factor and shear stress-induced platelet aggregation in patients with aortic valve stenosis.
Circulation 2000;102(11):1290-5.
2000: Zaverio M Ruggeri
Developing basic and clinical research on von Willebrand factor and von Willebrand disease.
Thrombosis and haemostasis 2000;84(2):147-9.
2000: Sona Vasudevan; J R Roberts; Richard McClintock; Judith A Dent; Reha Celikel; Jerry Ware; Kottayil I Varughese; Zaverio M Ruggeri
Modeling and functional analysis of the interaction between von Willebrand factor A1 domain and glycoprotein Ibalpha.
The Journal of biological chemistry 2000;275(17):12763-8.
2000: Jerry Ware; Susan Russell; Zaverio M Ruggeri
Generation and rescue of a murine model of platelet dysfunction: the Bernard-Soulier syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(6):2803-8.
2000: Zaverio M Ruggeri
Old concepts and new developments in the study of platelet aggregation.
The Journal of clinical investigation 2000;105(6):699-701.
1999: Brian Savage; Mark H Ginsberg; Zaverio M Ruggeri
Influence of fibrillar collagen structure on the mechanisms of platelet thrombus formation under flow.
Blood 1999;94(8):2704-15.
1999: Zaverio M Ruggeri
Structure and function of von Willebrand factor.
Thrombosis and haemostasis 1999;82(2):576-84.
1999: Miriam Galbusera; Marina Noris; C Rossi; Silvia Orisio; Jessica Caprioli; Zaverio M Ruggeri; B Amadei; Piero Ruggenenti; B Vasile; G Casari; Giuseppe Remuzzi
Increased fragmentation of von Willebrand factor, due to abnormal cleavage of the subunit, parallels disease activity in recurrent hemolytic uremic syndrome and thrombotic thrombocytopenic purpura and discloses predisposition in families. The Italian Registry of Familial and Recurrent HUS/TTP.
Blood 1999;94(2):610-20.
1999: Patrizia Marchese; Enrique Saldívar; Jerry Ware; Zaverio M Ruggeri
Adhesive properties of the isolated amino-terminal domain of platelet glycoprotein Ibalpha in a flow field.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(14):7837-42.
1999: Zaverio M Ruggeri; Judith A Dent; Enrique Saldívar
Contribution of distinct adhesive interactions to platelet aggregation in flowing blood.
Blood 1999;94(1):172-8.
1999: S Miyata; Zaverio M Ruggeri
Distinct structural attributes regulating von Willebrand factor A1 domain interaction with platelet glycoprotein Ibalpha under flow.
The Journal of biological chemistry 1999;274(10):6586-93.
1998: Marcie Kritzik; Brian Savage; Diane J Nugent; Sentot Santoso; Zaverio M Ruggeri; Thomas J Kunicki
Nucleotide polymorphisms in the alpha2 gene define multiple alleles that are associated with differences in platelet alpha2 beta1 density.
Blood 1998;92(7):2382-8.
1998: Brian Savage; F Almus-Jacobs; Zaverio M Ruggeri
Specific synergy of multiple substrate-receptor interactions in platelet thrombus formation under flow.
Cell 1998;94(5):657-66.
1998: Reha Celikel; Kottayil I Varughese; A Yoshioka; Jerry Ware; Zaverio M Ruggeri
Crystal structure of the von Willebrand factor A1 domain in complex with the function blocking NMC-4 Fab.
Nature structural biology 1998;5(3):189-94.
1998: Mario Mazzucato; L D Marco; A Masotti; Paola Pradella; W F Bahou; Zaverio M Ruggeri
Characterization of the initial alpha-thrombin interaction with glycoprotein Ib alpha in relation to platelet activation.
The Journal of biological chemistry 1998;273(4):1880-7.
1998: S Goto; Y Ikeda; Enrique Saldívar; Zaverio M Ruggeri
Distinct mechanisms of platelet aggregation as a consequence of different shearing flow conditions.
The Journal of clinical investigation 1998;101(2):479-86.
1997: Zaverio M Ruggeri
von Willebrand factor.
The Journal of clinical investigation 1997;100(11 Suppl):S41-6.
1997: Augusto B Federici; Pier M Mannucci; F Stabile; Maria Teresa Canciani; N Di Rocco; S Miyata; Jerry Ware; Zaverio M Ruggeri
A type 2b von Willebrand disease mutation (Ile546-->Val) associated with an unusual phenotype.
Thrombosis and haemostasis 1997;78(3):1132-7.
1997: Jerry Ware; Susan Russell; Zaverio M Ruggeri
Cloning of the murine platelet glycoprotein Ibalpha gene highlighting species-specific platelet adhesion.
Blood cells, molecules & diseases 1997;23(2):292-301.
1997: Paola Lanza; Brunhilde Felding-Habermann; Zaverio M Ruggeri; Maurizio Zanetti; Rosario Billetta
Selective interaction of a conformationally-constrained Arg-Gly-Asp (RGD) motif with the integrin receptor alphavbeta3 expressed on human tumor cells.
Blood cells, molecules & diseases 1997;23(2):230-41.
1997: Zaverio M Ruggeri
Mechanisms initiating platelet thrombus formation.
Thrombosis and haemostasis 1997;78(1):611-6.
1997: Zaverio M Ruggeri
von Willebrand factor.
The Journal of clinical investigation 1997;99(4):559-64.
1997: Reha Celikel; Kottayil I Varughese; M Shima; A Yoshioka; Jerry Ware; Zaverio M Ruggeri
Crystal structure of NMC-4 fab anti-von Willebrand factor A1 domain.
Blood cells, molecules & diseases 1997;23(1):123-34.
1996: I Stuiver; Zaverio M Ruggeri; J W Smith
Divalent cations regulate the organization of integrins alpha v beta 3 and alpha v beta 5 on the cell surface.
Journal of cellular physiology 1996;168(3):521-31.
1996: Reinhard Schneppenheim; J Brassard; S Krey; Ulrich Budde; T J Kunicki; L Holmberg; Jerry Ware; Zaverio M Ruggeri
Defective dimerization of von Willebrand factor subunits due to a Cys-> Arg mutation in type IID von Willebrand disease.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(8):3581-6.
1996: S Miyata; S Goto; A B Federici; Jerry Ware; Zaverio M Ruggeri
Conformational changes in the A1 domain of von Willebrand factor modulating the interaction with platelet glycoprotein Ibalpha.
The Journal of biological chemistry 1996;271(15):9046-53.
1996: Brunhilde Felding-Habermann; R Habermann; Enrique Saldívar; Zaverio M Ruggeri
Role of beta3 integrins in melanoma cell adhesion to activated platelets under flow.
The Journal of biological chemistry 1996;271(10):5892-900.
1996: Brian Savage; Enrique Saldívar; Zaverio M Ruggeri
Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor.
Cell 1996;84(2):289-97.
1995: Brian Savage; E Bottini; Zaverio M Ruggeri
Interaction of integrin alpha IIb beta 3 with multiple fibrinogen domains during platelet adhesion.
The Journal of biological chemistry 1995;270(48):28812-7.
1995: S Goto; Daniel R Salomon; Y Ikeda; Zaverio M Ruggeri
Characterization of the unique mechanism mediating the shear-dependent binding of soluble von Willebrand factor to platelets.
The Journal of biological chemistry 1995;270(40):23352-61.
1995: A J Pelletier; Thomas J Kunicki; Zaverio M Ruggeri; Vito Quaranta
The activation state of the integrin alpha IIb beta 3 affects outside-in signals leading to cell spreading and focal adhesion kinase phosphorylation.
The Journal of biological chemistry 1995;270(30):18133-40.
1995: Zaverio M Ruggeri
The role of von Willebrand factor and fibrinogen in the initiation of platelet adhesion to thrombogenic surfaces.
Thrombosis and haemostasis 1995;74(1):460-3.
1995: S Honda; Y Tomiyama; A J Pelletier; D Annis; Y Honda; R Orchekowski; Zaverio M Ruggeri; Thomas J Kunicki
Topography of ligand-induced binding sites, including a novel cation-sensitive epitope (AP5) at the amino terminus, of the human integrin beta 3 subunit.
The Journal of biological chemistry 1995;270(20):11947-54.
1995: P Marchese; M Murata; Mario Mazzucato; Paola Pradella; Luigi De Marco; Jerry Ware; Zaverio M Ruggeri
Identification of three tyrosine residues of glycoprotein Ib alpha with distinct roles in von Willebrand factor and alpha-thrombin binding.
The Journal of biological chemistry 1995;270(16):9571-8.
1995: Zaverio M Ruggeri
Von Willebrand's disease and the mechanisms of platelet function.
Ciba Foundation symposium 1995;189():35-45; discussion 45-50, 77-8.
1994: Zaverio M Ruggeri
Pathogenesis and classification of von Willebrand disease.
Haemostasis 1994;24(5):265-75.
1994: Zaverio M Ruggeri
New insights into the mechanisms of platelet adhesion and aggregation.
Seminars in hematology 1994;31(3):229-39.
1994: Zaverio M Ruggeri
Glycoprotein Ib and von Willebrand factor in the process of thrombus formation.
Annals of the New York Academy of Sciences 1994;714():200-10.
1994: A Tomer; R E Scharf; R McMillan; Zaverio M Ruggeri; LA Harker
Bernard-Soulier syndrome: quantitative characterization of megakaryocytes and platelets by flow cytometric and platelet kinetic measurements.
European journal of haematology 1994;52(4):193-200.
1994: Luigi De Marco; Mario Mazzucato; A Masotti; Zaverio M Ruggeri
Localization and characterization of an alpha-thrombin-binding site on platelet glycoprotein Ib alpha.
The Journal of biological chemistry 1994;269(9):6478-84.
1993: T P Ugarova; A Z Budzynski; Sanford J Shattil; Zaverio M Ruggeri; Mark H Ginsberg; Edward F Plow
Conformational changes in fibrinogen elicited by its interaction with platelet membrane glycoprotein GPIIb-IIIa.
The Journal of biological chemistry 1993;268(28):21080-7.
1993: Zaverio M Ruggeri
von Willebrand factor and fibrinogen.
Current opinion in cell biology 1993;5(5):898-906.
1993: Jerry Ware; S R Russell; P Marchese; M Murata; Mario Mazzucato; Luigi De Marco; Zaverio M Ruggeri
Point mutation in a leucine-rich repeat of platelet glycoprotein Ib alpha resulting in the Bernard-Soulier syndrome.
The Journal of clinical investigation 1993;92(3):1213-20.
1993: Zaverio M Ruggeri
Mechanisms of shear-induced platelet adhesion and aggregation.
Thrombosis and haemostasis 1993;70(1):119-23.
1993: M Sugimoto; J Dent; Richard McClintock; Jerry Ware; Zaverio M Ruggeri
Analysis of structure-function relationships in the platelet membrane glycoprotein Ib-binding domain of von Willebrand's factor by expression of deletion mutants.
The Journal of biological chemistry 1993;268(16):12185-92.
1993: L Holmberg; J A Dent; Reinhard Schneppenheim; Ulrich Budde; Jerry Ware; Zaverio M Ruggeri
von Willebrand factor mutation enhancing interaction with platelets in patients with normal multimeric structure.
The Journal of clinical investigation 1993;91(5):2169-77.
1993: M Murata; S R Russell; Zaverio M Ruggeri; Jerry Ware
Expression of the phenotypic abnormality of platelet-type von Willebrand disease in a recombinant glycoprotein Ib alpha fragment.
The Journal of clinical investigation 1993;91(5):2133-7.
1993: Jerry Ware; S R Russell; P Marchese; Zaverio M Ruggeri
Expression of human platelet glycoprotein Ib alpha in transgenic mice.
The Journal of biological chemistry 1993;268(11):8376-82.
1993: B R Alevriadou; Joel L Moake; Nancy A Turner; Zaverio M Ruggeri; B J Folie; M D Phillips; A B Schreiber; M E Hrinda; Larry V McIntire
Real-time analysis of shear-dependent thrombus formation and its blockade by inhibitors of von Willebrand factor binding to platelets.
Blood 1993;81(5):1263-76.
1993: H Azuma; T Hayashi; J A Dent; Zaverio M Ruggeri; Jerry Ware
Disulfide bond requirements for assembly of the platelet glycoprotein Ib-binding domain of von Willebrand factor.
The Journal of biological chemistry 1993;268(4):2821-7.
1993: H Azuma; M Sugimoto; Zaverio M Ruggeri; Jerry Ware
A role for von Willebrand factor proline residues 702-704 in ristocetin-mediated binding to platelet glycoprotein Ib.
Thrombosis and haemostasis 1993;69(2):192-6.
1993: Zaverio M Ruggeri; Jerry Ware
von Willebrand factor.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1993;7(2):308-16.
1992: R E Scharf; A Tomer; Ulla M Marzec; P S Teirstein; Zaverio M Ruggeri; LA Harker
Activation of platelets in blood perfusing angioplasty-damaged coronary arteries. Flow cytometric detection.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1992;12(12):1475-87.
1992: Zaverio M Ruggeri
von Willebrand factor as a target for antithrombotic intervention.
Circulation 1992;86(6 Suppl):III26-9.
1992: Brian Savage; Sanford J Shattil; Zaverio M Ruggeri
Modulation of platelet function through adhesion receptors. A dual role for glycoprotein IIb-IIIa (integrin alpha IIb beta 3) mediated by fibrinogen and glycoprotein Ib-von Willebrand factor.
The Journal of biological chemistry 1992;267(16):11300-6.
1992: M Murata; K Furihata; Fumihiro Ishida; S R Russell; Jerry Ware; Zaverio M Ruggeri
Genetic and structural characterization of an amino acid dimorphism in glycoprotein Ib alpha involved in platelet transfusion refractoriness.
Blood 1992;79(11):3086-90.
1992: Zaverio M Ruggeri; Jerry Ware
The structure and function of von Willebrand factor.
Thrombosis and haemostasis 1992;67(6):594-9.
1992: Brunhilde Felding-Habermann; Zaverio M Ruggeri; David A Cheresh
Distinct biological consequences of integrin alpha v beta 3-mediated melanoma cell adhesion to fibrinogen and its plasmic fragments.
The Journal of biological chemistry 1992;267(8):5070-7.
1992: Zaverio M Ruggeri; T S Zimmerman; S Russell; R Bader; Luigi De Marco
von Willebrand factor binding to platelet glycoprotein Ib complex.
Methods in enzymology 1992;215():263-75.
1991: Luigi De Marco; Mario Mazzucato; A Masotti; J W Fenton; Zaverio M Ruggeri
Function of glycoprotein Ib alpha in platelet activation induced by alpha-thrombin.
The Journal of biological chemistry 1991;266(35):23776-83.
1991: M Sugimoto; H Mohri; Richard McClintock; Zaverio M Ruggeri
Identification of discontinuous von Willebrand factor sequences involved in complex formation with botrocetin. A model for the regulation of von Willebrand factor binding to platelet glycoprotein Ib.
The Journal of biological chemistry 1991;266(27):18172-8.
1991: J A Dent; M Galbusera; Zaverio M Ruggeri
Heterogeneity of plasma von Willebrand factor multimers resulting from proteolysis of the constituent subunit.
The Journal of clinical investigation 1991;88(3):774-82.
1991: M Murata; Jerry Ware; Zaverio M Ruggeri
Site-directed mutagenesis of a soluble recombinant fragment of platelet glycoprotein Ib alpha demonstrating negatively charged residues involved in von Willebrand factor binding.
The Journal of biological chemistry 1991;266(23):15474-80.
1991: Zaverio M Ruggeri
Structure and function of von Willebrand factor: relationship to von Willebrand's disease.
Mayo Clinic proceedings. Mayo Clinic 1991;66(8):847-61.
1991: Brian Savage; Zaverio M Ruggeri
Selective recognition of adhesive sites in surface-bound fibrinogen by glycoprotein IIb-IIIa on nonactivated platelets.
The Journal of biological chemistry 1991;266(17):11227-33.
1991: M Sugimoto; G Ricca; M E Hrinda; A B Schreiber; G H Searfoss; E Bottini; Zaverio M Ruggeri
Functional modulation of the isolated glycoprotein Ib binding domain of von Willebrand factor expressed in Escherichia coli.
Biochemistry 1991;30(21):5202-9.
1991: Jerry Ware; J A Dent; H Azuma; M Sugimoto; P A Kyrle; A Yoshioka; Zaverio M Ruggeri
Identification of a point mutation in type IIB von Willebrand disease illustrating the regulation of von Willebrand factor affinity for the platelet membrane glycoprotein Ib-IX receptor.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(7):2946-50.
1990: Luigi De Marco; Mario Mazzucato; D De Roia; Alessandra Casonato; Augusto B Federici; A Girolami; Zaverio M Ruggeri
Distinct abnormalities in the interaction of purified types IIA and IIB von Willebrand factor with the two platelet binding sites, glycoprotein complexes Ib-IX and IIb-IIIa.
The Journal of clinical investigation 1990;86(3):785-92.
1990: J A Dent; Scott Darrell Berkowitz; Jerry Ware; C K Kasper; Zaverio M Ruggeri
Identification of a cleavage site directing the immunochemical detection of molecular abnormalities in type IIA von Willebrand factor.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(16):6306-10.
1990: Brian Savage; Ulla M Marzec; B H Chao; LA Harker; J M Maraganore; Zaverio M Ruggeri
Binding of the snake venom-derived proteins applaggin and echistatin to the arginine-glycine-aspartic acid recognition site(s) on platelet glycoprotein IIb.IIIa complex inhibits receptor function.
The Journal of biological chemistry 1990;265(20):11766-72.
1990: Luigi De Marco; Mario Mazzucato; Fabrizio Fabris; D De Roia; P Coser; A Girolami; V Vicente; Zaverio M Ruggeri
Variant Bernard-Soulier syndrome type bolzano. A congenital bleeding disorder due to a structural and functional abnormality of the platelet glycoprotein Ib-IX complex.
The Journal of clinical investigation 1990;86(1):25-31.
1990: Ulrich Budde; Reinhard Schneppenheim; H Plendl; J Dent; Zaverio M Ruggeri; T S Zimmerman
Luminographic detection of von Willebrand factor multimers in agarose gels and on nitrocellulose membranes.
Thrombosis and haemostasis 1990;63(2):312-5.
1990: J Ware; S R Russell; V Vicente; R E Scharf; A Tomer; R McMillan; Zaverio M Ruggeri
Nonsense mutation in the glycoprotein Ib alpha coding sequence associated with Bernard-Soulier syndrome.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(5):2026-30.
1990: V Vicente; R A Houghten; Zaverio M Ruggeri
Identification of a site in the alpha chain of platelet glycoprotein Ib that participates in von Willebrand factor binding.
The Journal of biological chemistry 1990;265(1):274-80.
1990: S A Berliner; R A Houghten; J R Roberts; Zaverio M Ruggeri
Multiple epitope specificity of monoclonal antibodies to a single synthetic peptide: use in the characterization of the GP IIb-IIIa binding domain of von Willebrand factor.
Advances in experimental medicine and biology 1990;281():133-44.
1989: Alessandra Casonato; Luigi De Marco; Mario Mazzucato; V De Angelis; D De Roia; Fabrizio Fabris; Zaverio M Ruggeri; A Girolami
A new congenital platelet abnormality characterized by spontaneous platelet aggregation, enhanced von Willebrand factor platelet interaction, and the presence of all von Willebrand factor multimers in plasma.
Blood 1989;74(6):2028-33.
1989: H Mohri; A Yoshioka; T S Zimmerman; Zaverio M Ruggeri
Isolation of the von Willebrand factor domain interacting with platelet glycoprotein Ib, heparin, and collagen and characterization of its three distinct functional sites.
The Journal of biological chemistry 1989;264(29):17361-7.
1989: M F Lopez-Fernandez; J Batlle; Zaverio M Ruggeri; T S Zimmerman
Secretion of von Willebrand factor from platelets.
Methods in enzymology 1989;169():244-51.
1988: Stephen R Hanson; F I Pareti; Zaverio M Ruggeri; Ulla M Marzec; Thomas J Kunicki; R R Montgomery; T S Zimmerman; L A Harker
Effects of monoclonal antibodies against the platelet glycoprotein IIb/IIIa complex on thrombosis and hemostasis in the baboon.
The Journal of clinical investigation 1988;81(1):149-58.
1987: Luigi De Marco; M Mazzuccato; M Grazia Del Ben; U Budde; Augusto B Federici; A Girolami; Zaverio M Ruggeri
Type IIB von Willebrand factor with normal sialic acid content induces platelet aggregation in the absence of ristocetin. Role of platelet activation, fibrinogen, and two distinct membrane receptors.
The Journal of clinical investigation 1987;80(2):475-82.
1987: Javier Batlle; M F Lopez-Fernandez; A Lopez-Borrasca; C Lopez-Berges; J A Dent; Scott Darrell Berkowitz; Zaverio M Ruggeri; T S Zimmerman
Proteolytic degradation of von Willebrand factor after DDAVP administration in normal individuals.
Blood 1987;70(1):173-6.
1986: Ulrich Budde; J A Dent; Scott Darrell Berkowitz; Zaverio M Ruggeri; T S Zimmerman
Subunit composition of plasma von Willebrand factor in patients with the myeloproliferative syndrome.
Blood 1986;68(6):1213-7.
1986: Javier Batlle; M F Lopez Fernandez; M Campos; B Justica; C Berges; J L Navarro; juan diaz cremades; C K Kasper; J A Dent; Zaverio M Ruggeri
The heterogeneity of type IIA von Willebrand's disease: studies with protease inhibitors.
Blood 1986;68(6):1207-12.
1986: F I Pareti; Y Fujimura; J A Dent; L Z Holland; T S Zimmerman; Zaverio M Ruggeri
Isolation and characterization of a collagen binding domain in human von Willebrand factor.
The Journal of biological chemistry 1986;261(32):15310-5.
1986: Javier Batlle; M F Lopez Fernandez; J Lasierra; A Fernandez Villamor; C Lopez Berges; A Lopez Borrasca; Zaverio M Ruggeri; T S Zimmerman
von Willebrand disease type IIC with different abnormalities of von Willebrand factor in the same sibship.
American journal of hematology 1986;21(2):177-88.
1984: Augusto B Federici; J H Elder; Luigi De Marco; Zaverio M Ruggeri; T S Zimmerman
Carbohydrate moiety of von Willebrand factor is not necessary for maintaining multimeric structure and ristocetin cofactor activity but protects from proteolytic degradation.
The Journal of clinical investigation 1984;74(6):2049-55.
1980: Zaverio M Ruggeri; F I Pareti; P M Mannucci; N Ciavarella; T S Zimmerman
Heightened interaction between platelets and factor VIII/von Willebrand factor in a new subtype of von Willebrand's disease.
The New England journal of medicine 1980;302(19):1047-51.