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Ariel Ruiz i Altaba

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TOP 3
Ariel Ruiz i Altaba
Hedgehog signaling and the Gli code in stem cells, cancer, and metastases.
Aiala Lorente-Trigos; Frédéric VARNAT; Alice Melotti; Ariel Ruiz i Altaba
BMP signaling promotes the growth of primary human colon carcinomas in vivo.
Frédéric VARNAT; Irene Siegl-Cachedenier; Monica Malerba; Pascal Gervaz; Ariel Ruiz i Altaba
Loss of WNT-TCF addiction and enhancement of HH-GLI1 signalling define the metastatic transition of human colon carcinomas.

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All Publications

2011: Ariel Ruiz i Altaba
Hedgehog signaling and the Gli code in stem cells, cancer, and metastases.
Science signaling 2011;4(200):pt9.
2010: Aiala Lorente-Trigos; Frédéric VARNAT; Alice Melotti; Ariel Ruiz i Altaba
BMP signaling promotes the growth of primary human colon carcinomas in vivo.
Journal of molecular cell biology 2010;2(6):318-32.
2010: Frédéric VARNAT; Irene Siegl-Cachedenier; Monica Malerba; Pascal Gervaz; Ariel Ruiz i Altaba
Loss of WNT-TCF addiction and enhancement of HH-GLI1 signalling define the metastatic transition of human colon carcinomas.
EMBO molecular medicine 2010;2(11):440-57.
2010: Christophe Mas; Ariel Ruiz i Altaba
Small molecule modulation of HH-GLI signaling: current leads, trials and tribulations.
Biochemical pharmacology 2010;80(5):712-23.
2010: Marie Zbinden; Arnaud Duquet; Aiala Lorente-Trigos; Sandra-Nadia Ngwabyt; Isabel Borges; Ariel Ruiz i Altaba
NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53.
The EMBO journal 2010;29(15):2659-74.
2010: Barbara Stecca; Ariel Ruiz i Altaba
Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals.
Journal of molecular cell biology 2010;2(2):84-95.
2010: Frédéric VARNAT; Giovanna Zacchetti; Ariel Ruiz i Altaba
Hedgehog pathway activity is required for the lethality and intestinal phenotypes of mice with hyperactive Wnt signaling.
Mechanisms of development 2010;127(1-2):73-81.
2009: Frédéric VARNAT; Arnaud Duquet; Monica Malerba; Marie Zbinden; Christophe Mas; Pascal Gervaz; Ariel Ruiz i Altaba
Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion.
EMBO molecular medicine 2009;1(6-7):338-51.
2009: Ariel Ruiz i Altaba; Andrea H Brand
Entity versus property: tracking the nature, genesis and role of stem cells in cancer. Conference on Stem cells and cancer.
EMBO reports 2009;10(8):832-6.
2009: Barbara Stecca; Ariel Ruiz i Altaba
A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers.
The EMBO journal 2009;28(6):663-76.
2008: Ariel Ruiz i Altaba
Therapeutic inhibition of Hedgehog-GLI signaling in cancer: epithelial, stromal, or stem cell targets?
Cancer cell 2008;14(4):281-3.
2007: Ariel Ruiz i Altaba; Christophe Mas; Barbara Stecca
The Gli code: an information nexus regulating cell fate, stemness and cancer.
Trends in cell biology 2007;17(9):438-47.
2007: Barbara Stecca; Christophe Mas; Virginie Clement; Marie Zbinden; Rafael Correa; vincent piguet; Friedrich Beermann; Ariel Ruiz i Altaba
Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(14):5895-900.
2007: Virginie Clement; Pilar Sanchez; Nicolas de Tribolet; Ivan Radovanovic; Ariel Ruiz i Altaba
HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity.
Current biology : CB 2007;17(2):165-72.
2005: Barbara Stecca; Ariel Ruiz i Altaba
Brain as a paradigm of organ growth: Hedgehog-Gli signaling in neural stem cells and brain tumors.
Journal of neurobiology 2005;64(4):476-90.
2005: Barbara Stecca; Christophe Mas; Ariel Ruiz i Altaba
Interference with HH-GLI signaling inhibits prostate cancer.
Trends in molecular medicine 2005;11(5):199-203.
2005: Pilar Sanchez; Virginie Clement; Ariel Ruiz i Altaba
Therapeutic targeting of the Hedgehog-GLI pathway in prostate cancer.
Cancer research 2005;65(8):2990-2.
2005: Pilar Sanchez; Ariel Ruiz i Altaba
In vivo inhibition of endogenous brain tumors through systemic interference of Hedgehog signaling in mice.
Mechanisms of development 2005;122(2):223-30.
2005: Verónica Palma; Daniel A Lim; Nadia Dahmane; Pilar Sánchez; Thomas C Brionne; Claudia D Herzberg; Yorick Gitton; Alan Carleton; Arturo Alvarez-Buylla; Ariel Ruiz i Altaba
Sonic hedgehog controls stem cell behavior in the postnatal and adult brain.
Development (Cambridge, England) 2005;132(2):335-44.
2004: Pilar Sanchez; Ana Maria Hernández; Barbara Stecca; Andrea J Kahler; Amy M DeGueme; Andrea Barrett; Mercedes Beyna; Milton W Datta; Sumana Datta; Ariel Ruiz i Altaba
Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(34):12561-6.
2004: Ariel Ruiz i Altaba; Barbara Stecca; Pilar Sánchez
Hedgehog--Gli signaling in brain tumors: stem cells and paradevelopmental programs in cancer.
Cancer letters 2004;204(2):145-57.
2004: Verónica Palma; Ariel Ruiz i Altaba
Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex.
Development (Cambridge, England) 2004;131(2):337-45.
2003: Erich Roessler; Yang-Zhu Du; José L Mullor; Esther Casas; William P Allen; Gabriele Gillessen-Kaesbach; Elizabeth R Roeder; Jeffrey E Ming; Ariel Ruiz i Altaba; Maximilian Muenke
Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephaly-like features.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(23):13424-9.
2003: Ariel Ruiz i Altaba; Vân Nguyên; Verónica Palma
The emergent design of the neural tube: prepattern, SHH morphogen and GLI code.
Current opinion in genetics & development 2003;13(5):513-21.
2003: Isabel Guerrero; Ariel Ruiz i Altaba
Development. Longing for ligand: hedgehog, patched, and cell death.
Science (New York, N.Y.) 2003;301(5634):774-6.
2002: Yorick Gitton; Nadia Dahmane; Sonya Baik; Ariel Ruiz i Altaba; Lorenz Neidhardt; Manuela Scholze; Bernhard G Herrmann; Pascal Kahlem; Alia Benkahla; Sabine Schrinner; Reha Yildirimman; Ralf Herwig; Hans Lehrach; Marie-Laure Yaspo
A gene expression map of human chromosome 21 orthologues in the mouse.
Nature 2002;420(6915):586-90.
2002: Barbara Stecca; Ariel Ruiz i Altaba
The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway.
Journal of biology 2002;1(2):9.
2002: Ariel Ruiz i Altaba; Pilar Sánchez; Nadia Dahmane
Gli and hedgehog in cancer: tumours, embryos and stem cells.
Nature reviews. Cancer 2002;2(5):361-72.
2002: Ariel Ruiz i Altaba; Verónica Palma; Nadia Dahmane
Hedgehog-Gli signalling and the growth of the brain.
Nature reviews. Neuroscience 2002;3(1):24-33.
2002: José L Mullor; Ariel Ruiz i Altaba
Growth, hedgehog and the price of GAS.
BioEssays : news and reviews in molecular, cellular and developmental biology 2002;24(1):22-6.
2001: Nadia Dahmane; Pilar Sánchez; Yorick Gitton; Verónica Palma; T Sun; Mercedes Beyna; H Weiner; Ariel Ruiz i Altaba
The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis.
Development (Cambridge, England) 2001;128(24):5201-12.
2001: Ariel Ruiz i Altaba; Yorick Gitton; Nadia Dahmane
Embryonic regionalization of the neocortex.
Mechanisms of development 2001;107(1-2):3-11.
2001: José L Mullor; Nadia Dahmane; T Sun; Ariel Ruiz i Altaba
Wnt signals are targets and mediators of Gli function.
Current biology : CB 2001;11(10):769-73.
2000: R Brewster; Ariel Ruiz i Altaba
Hexokinase I is a Gli2-responsive gene expressed in the embryonic CNS.
Mechanisms of development 2000;99(1-2):159-62.
2000: R Brewster; José L Mullor; Ariel Ruiz i Altaba
Gli2 functions in FGF signaling during antero-posterior patterning.
Development (Cambridge, England) 2000;127(20):4395-405.
1999: Ariel Ruiz i Altaba
Gli proteins and Hedgehog signaling: development and cancer.
Trends in genetics : TIG 1999;15(10):418-25.
1999: Ariel Ruiz i Altaba
Gli proteins encode context-dependent positive and negative functions: implications for development and disease.
Development (Cambridge, England) 1999;126(14):3205-16.
1999: Nadia Dahmane; Ariel Ruiz i Altaba
Sonic hedgehog regulates the growth and patterning of the cerebellum.
Development (Cambridge, England) 1999;126(14):3089-100.
1998: R Brewster; J Lee; Ariel Ruiz i Altaba
Gli/Zic factors pattern the neural plate by defining domains of cell differentiation.
Nature 1998;393(6685):579-83.
1998: Ariel Ruiz i Altaba
Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog.
Development (Cambridge, England) 1998;125(12):2203-12.
1997: Nadia Dahmane; J Lee; P Robins; P Heller; Ariel Ruiz i Altaba
Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours.
Nature 1997;389(6653):876-81.
1997: Ariel Ruiz i Altaba
Catching a Gli-mpse of Hedgehog.
Cell 1997;90(2):193-6.
1997: J Lee; K A Platt; P Censullo; Ariel Ruiz i Altaba
Gli1 is a target of Sonic hedgehog that induces ventral neural tube development.
Development (Cambridge, England) 1997;124(13):2537-52.